KR101893423B1 - 표적화 기체-충전 미세소포 - Google Patents

표적화 기체-충전 미세소포 Download PDF

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Publication number
KR101893423B1
KR101893423B1 KR1020177027001A KR20177027001A KR101893423B1 KR 101893423 B1 KR101893423 B1 KR 101893423B1 KR 1020177027001 A KR1020177027001 A KR 1020177027001A KR 20177027001 A KR20177027001 A KR 20177027001A KR 101893423 B1 KR101893423 B1 KR 101893423B1
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South Korea
Prior art keywords
microvesicles
polypeptide
amino acid
seq
target
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KR1020177027001A
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English (en)
Korean (ko)
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KR20170113711A (ko
Inventor
티에리 베팅거
필립 부싸
베르나드 라미
사미르 셰르카위
이렌느 길베르-브리게
Original Assignee
브라코 스위스 에스.에이.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/221—Echographic preparations; Ultrasonic imaging preparations characterised by the targeting agent or modifying agent linked to the acoustically-active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/178—Lectin superfamily, e.g. selectins

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
KR1020177027001A 2010-08-09 2011-08-09 표적화 기체-충전 미세소포 Active KR101893423B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10172318.7 2010-08-09
EP10172318 2010-08-09
PCT/EP2011/063720 WO2012020030A1 (en) 2010-08-09 2011-08-09 Targeted gas-filled microvesicles

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020137005859A Division KR101783653B1 (ko) 2010-08-09 2011-08-09 표적화 기체-충전 미세소포

Publications (2)

Publication Number Publication Date
KR20170113711A KR20170113711A (ko) 2017-10-12
KR101893423B1 true KR101893423B1 (ko) 2018-08-31

Family

ID=43216307

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020177027001A Active KR101893423B1 (ko) 2010-08-09 2011-08-09 표적화 기체-충전 미세소포
KR1020137005859A Active KR101783653B1 (ko) 2010-08-09 2011-08-09 표적화 기체-충전 미세소포

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020137005859A Active KR101783653B1 (ko) 2010-08-09 2011-08-09 표적화 기체-충전 미세소포

Country Status (15)

Country Link
US (2) US9211348B2 (https=)
EP (2) EP2603242B1 (https=)
JP (1) JP5779646B2 (https=)
KR (2) KR101893423B1 (https=)
CN (1) CN103079599B (https=)
AU (1) AU2011288511B2 (https=)
BR (1) BR112013003393B1 (https=)
CA (1) CA2806639C (https=)
DK (2) DK3338807T3 (https=)
ES (2) ES2848721T3 (https=)
HU (2) HUE052894T2 (https=)
IL (1) IL224628A (https=)
SI (2) SI2603242T1 (https=)
WO (1) WO2012020030A1 (https=)
ZA (1) ZA201300660B (https=)

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AU2013255952B2 (en) * 2012-04-30 2018-04-12 Ge Healthcare As Method for filling a container with a foamable composition
CN103565745A (zh) * 2012-08-10 2014-02-12 德克萨斯州大学系统董事会 用于治疗中风的神经保护性脂质体组合物和方法
EP2934740B1 (en) * 2012-12-21 2019-12-11 Bracco Suisse SA Gas-filled microvesicles
CA3132914C (en) 2013-03-15 2023-11-07 The Board Of Regents Of The University Of Texas System Liquids rich in noble gas and methods of their preparation and use
WO2015134671A1 (en) 2014-03-04 2015-09-11 Targeson, Inc. Molecular imaging contrast agents and uses thereof
EP3233136B8 (en) 2014-12-18 2019-04-10 Bracco Suisse SA Targeted gas-filled microvesicles formulation
CN107206065A (zh) * 2014-12-22 2017-09-26 博莱科瑞士股份有限公司 用作疫苗的气体填充的微囊
ES3030273T3 (en) * 2015-10-08 2025-06-27 Childrens Medical Ct Corp Compositions and compositions for use in on-demand high-efficiency triggerable anesthesia
IL260957B2 (en) * 2016-02-09 2023-11-01 Bracco Suisse Sa Chimeric, Recombinant Protein Glycoprotein Selectin-P Ligand-1 (PSGL-1) Conjugates, Preparations Containing Them and Uses Thereof
WO2019126182A1 (en) * 2017-12-18 2019-06-27 The University Of Memphis Research Foundation Compositions and methods for the detection and molecular profiling of membrane bound vesicles
WO2020132074A1 (en) 2018-12-18 2020-06-25 The University Of Memphis Research Foundation Compositions and methods for the detection and molecular profiling of membrane bound vesicles
ES2984146T3 (es) 2018-12-21 2024-10-29 Bracco Suisse Sa Microvesículas llenas de gas con ligando

Citations (1)

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WO2008131217A1 (en) 2007-04-20 2008-10-30 Oregon Healty & Science University Ultrasound imaging with targeted microbubbles

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US4276885A (en) 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
IE61591B1 (en) 1987-12-29 1994-11-16 Molecular Biosystems Inc Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production
US5556610A (en) 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
US5445813A (en) 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
IN172208B (https=) 1990-04-02 1993-05-01 Sint Sa
AU636481B2 (en) 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
US5843707A (en) 1992-10-23 1998-12-01 Genetics Institute, Inc. Nucleic acid encoding a novel P-selectin ligand protein
EP1550464A1 (en) 1993-07-30 2005-07-06 IMCOR Pharmaceutical Co. Stabilized microbubble composition for ultrasound
US6333021B1 (en) 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
IL116328A (en) 1994-12-16 1999-09-22 Bracco Research Sa Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging
WO1997029782A1 (en) 1996-02-19 1997-08-21 Nycomed Imaging A/S Thermally stabilized contrast agent
WO2001075107A2 (en) * 2000-03-31 2001-10-11 Genetics Institute, Llc. Use of p-selectin glycoprotein ligand-1 (psgl-1) and fragments thereof for the inhibition of thrombosis
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
JP4670083B2 (ja) * 2003-02-04 2011-04-13 ブラッコ・シュイス・ソシエテ・アノニム 超音波造影剤およびその製造方法
US20060241022A1 (en) 2004-10-06 2006-10-26 Bowen Benjamin P Selectin targeting bioconjugates
JP5242408B2 (ja) 2005-12-09 2013-07-24 ブラッコ・スイス・ソシエテ・アノニム ターゲットベクター・リン脂質コンジュゲート
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Patent Citations (1)

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WO2008131217A1 (en) 2007-04-20 2008-10-30 Oregon Healty & Science University Ultrasound imaging with targeted microbubbles

Non-Patent Citations (1)

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MOLECULAR PHARMACEUTICS VOL. 3, NO. 5, 516-524

Also Published As

Publication number Publication date
AU2011288511B2 (en) 2016-01-07
DK2603242T3 (en) 2018-06-18
CN103079599B (zh) 2017-05-10
BR112013003393B1 (pt) 2021-07-13
CN103079599A (zh) 2013-05-01
ES2848721T3 (es) 2021-08-11
ES2673277T3 (es) 2018-06-21
KR101783653B1 (ko) 2017-10-10
US20160074539A1 (en) 2016-03-17
JP2013535494A (ja) 2013-09-12
KR20130135838A (ko) 2013-12-11
US9211348B2 (en) 2015-12-15
DK3338807T3 (da) 2021-02-22
IL224628A (en) 2016-08-31
US20130156706A1 (en) 2013-06-20
KR20170113711A (ko) 2017-10-12
SI2603242T1 (sl) 2018-09-28
EP2603242A1 (en) 2013-06-19
HUE037768T2 (hu) 2018-09-28
JP5779646B2 (ja) 2015-09-16
EP3338807B1 (en) 2020-12-16
US9333273B2 (en) 2016-05-10
EP3338807A1 (en) 2018-06-27
SI3338807T1 (sl) 2021-06-30
ZA201300660B (en) 2013-09-25
BR112013003393A2 (pt) 2016-08-02
WO2012020030A1 (en) 2012-02-16
CA2806639A1 (en) 2012-02-16
CA2806639C (en) 2020-10-20
AU2011288511A1 (en) 2013-02-07
EP2603242B1 (en) 2018-03-14
HUE052894T2 (hu) 2021-05-28

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