KR101889290B1 - 레티노이드 수용체-선택적 경로와 관련된 방법 및 조성물 - Google Patents

레티노이드 수용체-선택적 경로와 관련된 방법 및 조성물 Download PDF

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KR101889290B1
KR101889290B1 KR1020127031894A KR20127031894A KR101889290B1 KR 101889290 B1 KR101889290 B1 KR 101889290B1 KR 1020127031894 A KR1020127031894 A KR 1020127031894A KR 20127031894 A KR20127031894 A KR 20127031894A KR 101889290 B1 KR101889290 B1 KR 101889290B1
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sulindac
cells
rxrα
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KR20130113932A (ko
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시아오-쿤 장
잉 수
후 조우
웬 리우
페이-치앙 후앙
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샌포드 번햄 프레비즈 메디컬 디스커버리 인스티튜트
시아먼 유니버시티
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
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    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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KR1020127031894A 2010-05-06 2011-05-06 레티노이드 수용체-선택적 경로와 관련된 방법 및 조성물 Expired - Fee Related KR101889290B1 (ko)

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US33212410P 2010-05-06 2010-05-06
US61/332,124 2010-05-06
PCT/US2011/035651 WO2011140525A2 (en) 2010-05-06 2011-05-06 Methods and compositions related to a retinoid receptor-selective pathway

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US (2) US9611235B2 (enExample)
EP (1) EP2571497B1 (enExample)
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CN (2) CN103002887B (enExample)
AU (1) AU2011249857B2 (enExample)
CA (1) CA2798692C (enExample)
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US9611235B2 (en) 2010-05-06 2017-04-04 Sanford-Burnham Medical Research Institute Methods and compositions related to a retinoid receptor-selective pathway
CN103491772A (zh) * 2011-04-01 2014-01-01 南方研究所 舒林酸衍生物、其用途及其制备
WO2015100267A1 (en) * 2013-12-23 2015-07-02 Sanford-Burnham Medical Research Institute Methods and compositions for treating cancer
WO2017193086A1 (en) * 2016-05-06 2017-11-09 Tarrex Biopharma Inc. Therapeutic compounds and methods
KR20230024976A (ko) * 2020-06-12 2023-02-21 누크미토 파마슈티컬스 컴퍼니, 리미티드 인덴 화합물, 이의 약제학적 조성물, 및 이의 치료학적 적용
CN117916215A (zh) * 2021-05-15 2024-04-19 藤济(厦门)生物医药科技有限公司 茚化合物、其药物组合物及其治疗应用
EP4619369A1 (en) * 2022-11-16 2025-09-24 Nucmito Pharmaceuticals Co., Ltd. Indene compounds, pharmaceutical compositions thereof, and their therapeutic applications

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005247807A (ja) * 2004-03-08 2005-09-15 Japan Science & Technology Agency Ｎｓａｉｄを利用した癌治療用組成物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001012858A1 (en) 1999-08-16 2001-02-22 The Johns Hopkins University PPARδ LINKS APC TO CHEMOPREVENTIVE DRUGS
DE10163426A1 (de) * 2001-12-21 2003-07-03 Max Planck Gesellschaft Pharmakologisch wirksame Inden-Derivate
AU2003298020A1 (en) * 2002-11-26 2004-06-18 Florida Atlantic University Catalytic antioxidants and methods of use
EP1668362A4 (en) 2003-08-13 2007-07-04 Burnham Inst CYTOPLASMATIC ACTIVITY OF THE RETINOID-X RECEPTOR AND ITS REGULATION BY LIGANDING AND DIMERIZATION
WO2006102439A2 (en) * 2005-03-23 2006-09-28 Florida Atlantic University Treatment or prevention of cancer and precancerous disorders
JP5337491B2 (ja) * 2006-01-04 2013-11-06 サザン リサーチ インスティテュート スリンダクの誘導体類、その使用及びその調製
WO2010070379A1 (en) 2008-12-17 2010-06-24 Centre National De La Recherche Scientifique Rxr-ppargamma agonist/growth factor inhibitor combination therapy for inducing apoptosis and the treatment of cancer
US9611235B2 (en) 2010-05-06 2017-04-04 Sanford-Burnham Medical Research Institute Methods and compositions related to a retinoid receptor-selective pathway
CN102030642A (zh) 2010-12-03 2011-04-27 厦门大学 舒林酸类似物的中间体的合成方法与应用
WO2015100267A1 (en) 2013-12-23 2015-07-02 Sanford-Burnham Medical Research Institute Methods and compositions for treating cancer
WO2017193086A1 (en) 2016-05-06 2017-11-09 Tarrex Biopharma Inc. Therapeutic compounds and methods

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005247807A (ja) * 2004-03-08 2005-09-15 Japan Science & Technology Agency Ｎｓａｉｄを利用した癌治療用組成物

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Biochimica et Biophysica Acta, 1999, vol. 1428, pp. 68~76*
Bioorganic & Medicinal Chemistry Letters, 2009, vol. 19, pp. 3271~3274*
Journal of Medicinal Chemistry, 2008, vol. 51, No. 16, pp. 4911~4919*

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CA2798692C (en) 2019-04-30
WO2011140525A2 (en) 2011-11-10
CA2798692A1 (en) 2011-11-10
CN107050007B (zh) 2020-06-30
US9611235B2 (en) 2017-04-04
KR20130113932A (ko) 2013-10-16
US20150266842A1 (en) 2015-09-24
EP2571497A2 (en) 2013-03-27
EP2571497A4 (en) 2013-12-04
JP2017008050A (ja) 2017-01-12
WO2011140525A3 (en) 2012-03-22
US10087156B2 (en) 2018-10-02
US20170313668A1 (en) 2017-11-02
AU2011249857B2 (en) 2015-03-12
AU2011249857A1 (en) 2012-12-06
JP6375340B2 (ja) 2018-08-15
CN103002887B (zh) 2016-12-21
CN107050007A (zh) 2017-08-18
CN103002887A (zh) 2013-03-27
EP2571497B1 (en) 2018-09-19
ES2702532T3 (es) 2019-03-01
JP2013533212A (ja) 2013-08-22

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