KR101854228B1 - 신규 아밀로이드 친화성 화합물 - Google Patents

신규 아밀로이드 친화성 화합물 Download PDF

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Publication number
KR101854228B1
KR101854228B1 KR1020137032274A KR20137032274A KR101854228B1 KR 101854228 B1 KR101854228 B1 KR 101854228B1 KR 1020137032274 A KR1020137032274 A KR 1020137032274A KR 20137032274 A KR20137032274 A KR 20137032274A KR 101854228 B1 KR101854228 B1 KR 101854228B1
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compound
pyridine
pyridin
triazol
mmol
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Korean (ko)
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KR20140040735A (ko
Inventor
유키 오쿠무라
요시후미 마야
요시나리 쇼야마
타카코 오니시
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니혼 메디피직스 가부시키가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020137032274A 2011-06-24 2012-05-29 신규 아밀로이드 친화성 화합물 Expired - Fee Related KR101854228B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011140069 2011-06-24
JPJP-P-2011-140069 2011-06-24
PCT/JP2012/063726 WO2012176587A1 (ja) 2011-06-24 2012-05-29 新規アミロイド親和性化合物

Publications (2)

Publication Number Publication Date
KR20140040735A KR20140040735A (ko) 2014-04-03
KR101854228B1 true KR101854228B1 (ko) 2018-05-03

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KR1020137032274A Expired - Fee Related KR101854228B1 (ko) 2011-06-24 2012-05-29 신규 아밀로이드 친화성 화합물

Country Status (11)

Country Link
US (1) US9211350B2 (https=)
EP (1) EP2725027B1 (https=)
JP (1) JP5167436B2 (https=)
KR (1) KR101854228B1 (https=)
CN (1) CN103596950B (https=)
AU (1) AU2012274639B2 (https=)
CA (1) CA2839199C (https=)
ES (1) ES2619830T3 (https=)
IN (1) IN2014DN00185A (https=)
TW (1) TWI554511B (https=)
WO (1) WO2012176587A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107105667B (zh) * 2014-08-29 2021-08-17 Chdi基金会股份有限公司 用于成像亨廷顿蛋白的探针
CN111372940A (zh) * 2017-09-19 2020-07-03 阿尔伯塔大学理事会 生物还原活化的化合物、其前药、放射性药物、组合物及其在包括癌症在内的低氧疾病的多模式治疗控制中的应用
JP6831802B2 (ja) * 2018-01-12 2021-02-17 上海富吉医療器械有限公司Ｓｈａｎｇｈａｉ Ｃｈａｒｔｗｅｌｌ Ｍｅｄｉｃａｌ Ｉｎｓｔｒｕｍｅｎｔ Ｃｏ．， Ｌｔｄ． 放射性核種標識化合物及びこれを含有するイメージング剤
JPWO2022244680A1 (https=) * 2021-05-18 2022-11-24

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100249419A1 (en) 2007-10-30 2010-09-30 Nihon Medi-Physics Co., Ltd. Utilization of novel compounds with amyloid affinity and method of producing the same

Family Cites Families (19)

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Publication number Priority date Publication date Assignee Title
AU759945B2 (en) 1998-08-20 2003-05-01 Regents Of The University Of California, The Methods for labeling beta-amyloid plaques and neurofibrillary tangles
RU2324686C2 (ru) 2000-08-24 2008-05-20 Юнивесити Оф Питсбэг ПРОИЗВОДНЫЕ ТИОФЛАВИНА, СВЯЗЫВАЮЩИЕ АМИЛОИД, СПОСОБ ОБНАРУЖЕНИЯ in vivo ОТЛОЖЕНИЙ АМИЛОИДА И СПОСОБ РАСПОЗНАВАНИЯ БОЛЕЗНИ АЛЬЦГЕЙМЕРА
CA2444214A1 (en) 2001-04-23 2002-10-31 The Trustees Of The University Of Pennsylvania Amyloid plaque aggregation inhibitors and diagnostic imaging agents
CN1299777C (zh) 2001-08-27 2007-02-14 宾夕法尼亚州大学理事会 茋衍生物及其用于结合和成像淀粉样蛋白斑的用途
US20080219922A1 (en) 2005-09-12 2008-09-11 Goodman Mark M Alzheimer's Disease Imaging Agents
WO2007063946A1 (ja) 2005-11-30 2007-06-07 Fujifilm Ri Pharma Co., Ltd. アミロイドの凝集及び／又は沈着に起因する疾患の診断薬及び治療薬
US8303935B2 (en) 2006-05-19 2012-11-06 Nihon Medi-Physics Co., Ltd. Alkoxy substituted imidazo[1,2-a]pyridines having affinity for amyloid
WO2007148755A1 (ja) 2006-06-21 2007-12-27 Nihon Medi-Physics Co., Ltd. 新規アミロイド親和性化合物
CA2670436A1 (en) 2006-11-30 2008-06-05 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
WO2008091195A1 (en) * 2007-01-22 2008-07-31 Astrazeneca Ab Novel heteroaryl substituted imidazo [1,2 -a] pyridine derivatives
KR20100091965A (ko) 2007-10-24 2010-08-19 니혼 메디피직스 가부시키가이샤 신규 아밀로이드 친화성 화합물
AU2008314871A1 (en) 2007-10-26 2009-04-30 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
WO2009057576A1 (ja) 2007-10-30 2009-05-07 Nihon Medi-Physics Co., Ltd. 新規アミロイド親和性化合物の使用及び製造方法
CA2704168A1 (en) 2007-10-30 2009-05-07 Nihon Medi-Physics Co., Ltd. Use of novel compound having affinity for amyloid, and process for production of the same
WO2009155024A1 (en) * 2008-05-30 2009-12-23 Merck & Co., Inc. Novel substituted indoles
EP2218464A1 (en) * 2009-02-11 2010-08-18 Technische Universität München Compounds for non-invasive measurement of aggregates of amyloid peptides
WO2010128595A1 (ja) 2009-05-07 2010-11-11 富士フイルムＲｉファーマ株式会社 放射性ヨウ素標識イミダゾピリジン誘導体の製造法
US20120263646A1 (en) 2009-10-15 2012-10-18 Guerbet Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases
AU2012259929B2 (en) * 2011-05-20 2016-08-04 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100249419A1 (en) 2007-10-30 2010-09-30 Nihon Medi-Physics Co., Ltd. Utilization of novel compounds with amyloid affinity and method of producing the same

Also Published As

Publication number Publication date
JP5167436B2 (ja) 2013-03-21
CA2839199C (en) 2018-11-06
US20140121377A1 (en) 2014-05-01
EP2725027A1 (en) 2014-04-30
KR20140040735A (ko) 2014-04-03
IN2014DN00185A (https=) 2015-07-10
EP2725027A4 (en) 2015-02-25
CN103596950B (zh) 2017-12-19
US9211350B2 (en) 2015-12-15
AU2012274639A1 (en) 2014-02-06
ES2619830T3 (es) 2017-06-27
TWI554511B (zh) 2016-10-21
AU2012274639B2 (en) 2016-08-11
JPWO2012176587A1 (ja) 2015-02-23
EP2725027B1 (en) 2017-03-01
CN103596950A (zh) 2014-02-19
WO2012176587A1 (ja) 2012-12-27
CA2839199A1 (en) 2012-12-27
TW201300388A (zh) 2013-01-01

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