KR101827767B1 - 닭 전염성 후두기관염 바이러스 약독화주 및 이를 포함하는 백신 조성물 - Google Patents

닭 전염성 후두기관염 바이러스 약독화주 및 이를 포함하는 백신 조성물 Download PDF

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KR101827767B1
KR101827767B1 KR1020160122049A KR20160122049A KR101827767B1 KR 101827767 B1 KR101827767 B1 KR 101827767B1 KR 1020160122049 A KR1020160122049 A KR 1020160122049A KR 20160122049 A KR20160122049 A KR 20160122049A KR 101827767 B1 KR101827767 B1 KR 101827767B1
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송창선
박승용
최인수
이중복
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Abstract

본 발명은 닭 전염성 후두기관염(Infectious laryngotracheitis) 바이러스 약독화주 및 이를 포함하는 백신 조성물에 관한 것으로, 본 발명의 약독화주는 상용 백신주들과 상이한 유전자 패턴을 갖는 닭 전염성 후두기관염 바이러스에 유의적인 예방 효과를 나타내고, 동물모델 실험에서 우수한 안전성을 나타내므로, 양계 농장에 심각한 피해를 일으키는 전염성 후두기관염 바이러스의 유전적 변이에 따른 새로운 변종에 대한 예방 백신으로 유용하게 사용될 수 있다.

Description

닭 전염성 후두기관염 바이러스 약독화주 및 이를 포함하는 백신 조성물{An attenuated chicken Infectious laryngotracheitis virus, and vaccine composition comprising the same}
본 발명은 닭 전염성 후두기관염(Infectious laryngotracheitis) 바이러스 약독화주 및 이를 포함하는 백신 조성물에 관한 것으로, 구체적으로, 기존 상용 백신주와 유전자형이 상이한 국내 야외주에서 분리한 닭 전염성 후두기관염 바이러스 약독화주 및 이를 포함하는 닭 전염성 후두기관염 생독 백신에 관한 것이다.
닭 전염성 후두기관염 바이러스(Infectious laryngotracheitis virus; ILTV)는 닭의 상부 호흡기에 감염되어 급성의 전염성 질환을 일으킨다. 전파는 다소 느린 편이지만 감염된군은 심한 호흡기 증상을 동반한 폐사를 보이며 폐사율은 감염주의 병원성에 따라 5~30%에 이른다.
자연감염되면 임상증상은 대개 6~12일을 전후하여 나타나며, 폐사한 닭을 부검하여 보면 기관 내에 심한 출혈성 점액을 보이는 타입과 노란색 치즈모양의 덩어리가 기관에 위막을 형성하는 타입의 소견을 관찰할 수 있다. 폐사원인은 기도가 폐쇄되어 호흡불능으로 질식사하며 개구호흡, 후두부 폐쇄, 결막염, 산란율 저하, 피가래, 기침, 호흡 곤란과 같은 증상을 동반하게 된다. 폐사는 발병한 지 3~5일 이내에 일어나는 경우가 많다.
닭의 면역이 다소 불량하거나 병원성이 약한 바이러스에 노출되었을 경우는 만성형의 증상을 보인다. 만성형은 산란율이 떨어지고 가벼운 호흡곤란을 일으켜 약한 기침과 호흡곤란을 보이며 결막염이 나타나기도 하지만 전형적인 ILTV 증상은 잘 관찰되지 않아 다른 호흡기 질병과 감별이 쉽지가 않다. 특히 감염되었다가 회복된 숙주는 바이러스가 뇌에 있는 삼차신경절에 잠복감염을 하게 되어 보균계로 남게 되며, 이들보균계의 면역력이 약화되거나 기타 스트레스성 요인에 노출되었을 때는 잠복 감염된 바이러스가 재활성화되어 다른 개체로 전파될 수 있다.
ILT는 1925년 미국에서 처음 알려졌으며 현재는 세계적으로 발생하고 있다. 국내에서는 1982년 경기도 강화군 소재 산란계 농장에서 처음 발생하여 전국으로 빠르게 확산하였으며 2003년까지 높은 수로 발생함이 농림축산검역본부에 의해서 진단되었다. 2004년 이후로 발생이 줄어들어 2006년부터 2008년까지는 발생보고가 없었으나 2009년 다시 질병이 발생하여 그 이듬해 심각하게 높은 수로 발생보고가 되었고 현재까지 계속 발병 보고가 진행되고 있다.
ILT의 효과적인 예방을 위해서는 위생적인 사양관리와 함께 예방접종을 하여야 한다. ILTV는 소독제에 약하고 계사 간의 전파가 느린 편이므로 바이러스가 들어오는 경로를 차단하고 계사의 주기적인 소독, 차량 소독조 및 발판 소독조를 설치하면 효과적이다. ILT를 막으려고 사용되고 있는 백신은 과거부터 약독화된 생백신이 사용되어 오고 있다.
약독화된 생백신은 두 가지로 분류가 된다. 종란계대에 의해 약독화된 종란유래(Chick Embryo Origin, CEO) 백신과 세포주계대에 의해 약독화된 세포주유래(Tissue Culture Origin, TCO) 백신이 있으며, 현재 국내에서 사용되고 있는 모든 상업용 백신은 종란유래 백신을 사용하고 있다. 과거 실험 결과에 의하면 종란유래 백신이 세포주유래 백신보다 뛰어난 방어력을 보여 주었으나, 종란유래 백신을 사용했을 경우 백신 접종 후 2~5일까지 미약한 기침 및 결막염을 동반한 백신접종반응을 보이며, 때론 폐사를 유발하기도 한다. 이에 반해 세포주유래 백신은 매우 안전하여 백신접종 반응이 없으나 단독으로 사용했을 경우 효과적으로 야외주를 방어할 수 없는 것으로 보고되었다.
이에, 본 발명자들은 기존 ILTV 상용화 백신과 유전자형이 상이하고, 양계농장의 피해가 심각한 야외주를 분리한 후, 이를 이용한 TCO 백신을 개발하기 위해 노력한 결과, 본 발명에서 확립한 유전자형 분석을 통해 기존 상용 백신주와 유전자형이 상이한 야외주를 선정하고, 이를 약독화 시킨 결과, 동물모델 실험에서 안전성 및 유의적인 예방 백신 효능을 나타냄을 확인함으로써, 본 발명의 약독화 백신을 상용 백신주들과 상이한 유전자 패턴을 갖는 닭 전염성 후두기관염 바이러스 예방용 백신으로 유용하게 사용될 수 있음을 밝힘으로써, 본 발명을 완성하였다.
본 발명의 목적은 상용 백신주들과 상이한 유전자 패턴을 갖는 닭 전염성 후두기관염 바이러스 예방용 백신 조성물을 제공하기 위한 것이다.
상기 목적을 달성하기 위하여, 본 발명은 기탁번호 KCTC 13022BP로 기탁된 전염성 후두기관염 바이러스(Infectious laryngotracheitis virus; ILTV) 약독화주를 제공한다.
또한, 본 발명은 본 발명의 전염성 후두기관염 바이러스 약독화주를 포함하는 가금류 전염성 후두기관염 예방용 백신 조성물을 제공한다.
아울러, 본 발명은 수의학적으로 허용가능한 양의 본 발명의 백신 조성물을 가금류에게 투여하는 단계를 포함하는 보호성 면역 반응 유도방법을 제공한다.
본 발명의 전염성 후두기관염 바이러스(Infectious laryngotracheitis virus; ILTV) 약독화주는 상용 백신주들과 상이한 유전자 패턴을 갖는 닭 전염성 후두기관염 바이러스에 유의적인 예방 효과를 나타내고, 동물모델 실험에서 우수한 안전성을 입증하였으므로, 양계 농장에 심각한 피해를 일으키는 전염성 후두기관염 바이러스의 유전적 변이에 따른 새로운 변종에 대한 유의적인 감염 예방 효과를 나타낸다.
도 1은 본 발명의 유전자형 검사법에 의한 국내 야외분리주 전염성 후두기관염 바이러스(Infectious laryngotracheitis virus; ILTV)의 유전자형 패턴 분석 결과를 나타낸 도이다.
도 2는 본 발명의 선별된 바이러스가 감염된 세포에서 CPE(Cytopathic effect)가 형성되는 것을 확인한 도이다.
도 3은 선별된 ILTV 백신후보 야외분리주의 Plaque purification을 진행한 LMH 세포에서의 Plaque 사진을 나타낸 도이다.
도 4는 세포에서의 계대수 별 Plaque 양상을 관찰한 결과를 나타낸 도이다.
도 5는 20계대 ILTV와 ILTV 상용 백신의 Plaque 양상을 비교한 도이다.
도 6은 세포에서의 계대수 별 CPE 양상을 관찰한 결과를 나타낸 도이다.
도 7은 세포에서의 계대수 별 CAM에서의 Pock 크기를 관찰한 결과를 나타낸 도이다.
도 8은 본 발명의 약독화주의 CAM에서의 Pock 크기를 관찰한 결과를 나타낸 도이다.
도 9는 본 발명의 약독화 백신 접종 후, 공격용 바이러스를 접종한 다음 증체량 변화를 확인한 도이다:
Positive control: 무처리+공격용 바이러스 처리군;
TCO 개발백신 최종 3: 본 발명의 백신+공격용 바이러스 처리군;
기 개발백신: Nobilis ILT(serva)+공격용 바이러스 처리군; 및
Negative control: 백신 접종군과의 대조군으로 백신 접종 시 및 공격용 바이러스 접종 시 DMEM 배지만을 접종한 negative control군.
도 10은 본 발명의 약독화 백신 접종 후, 공격용 바이러스를 접종한 다음 임상증상을 확인한 도이다:
Positive control: 무처리+공격용 바이러스 처리군;
최종 3(TCO-V1): 본 발명의 백신+공격용 바이러스 처리군;
기 개발백신: Nobilis ILT(serva)+공격용 바이러스 처리군; 및
Negative control: 백신접종군과의 대조군으로 백신 접종 시 및 공격용 바이러스 접종 시 DMEM 배지만을 접종한 negative control군.
도 11 본 발명의 약독화 백신 접종 후, 공격용 바이러스를 접종한 다음 바이러스 양을 측정한 도이다:
Positive: 무처리+공격용 바이러스 처리군;
최종 3(TCO-V1): 본 발명의 백신+공격용 바이러스 처리군;
기 개발백신: Nobilis ILT(serva)+공격용 바이러스 처리군; 및
Negative: 백신접종군과의 대조군으로 백신 접종 시 및 공격용 바이러스 접종 시 DMEM 배지만을 접종한 negative control군.
도 12는 본 발명의 약독화 백신 주의 기관 조직병변 및 섬모소실지수를 평가를 위한 세포 염색사진을 나타낸 도이다:
Positive control: 무처리+공격용 바이러스 처리군;
최종 3(TCO-V1): 본 발명의 백신+공격용 바이러스 처리군;
기 개발백신: Nobilis ILT(serva)+공격용 바이러스 처리군; 및
Negative control: 백신접종군과의 대조군으로 백신 접종 시 및 공격용 바이러스 접종 시 DMEM 배지만을 접종한 negative control군.
도 13은 본 발명의 약독화 백신 주의 기관 조직병변 및 섬모소실지수를 평가를 위한 그래프를 나타낸 도이다:
Positive: 무처리+공격용 바이러스 처리군;
최종 3(TCO-V1): 본 발명의 백신+공격용 바이러스 처리군;
기 개발백신: Nobilis ILT(serva)+공격용 바이러스 처리군; 및
Negative: 백신접종군과의 대조군으로 백신 접종 시 및 공격용 바이러스 접종 시 DMEM 배지만을 접종한 negative control군.
도 14는 본 발명에서 선정한 30678/14 주의 게놈 분석도를 나타낸 도이다.
도 15는 ILTV 바이러스 야외주와 표준주의 UL36 영역의 염기서열을 비교한 도이다.
도 16은 ILTV 바이러스 야외주와 표준주의 UL52 영역의 염기서열을 비교한 도이다.
도 17은 ILTV 바이러스 야외주와 표준주의 ICP4 영역의 염기서열을 비교한 도이다.
도 18은 ILTV 바이러스 야외주와 표준주의 UL27 영역의 염기서열을 비교한 도이다.
도 19는 ILTV 바이러스 야외주와 표준주의 US5 영역의 염기서열을 비교한 도이다.
도 20은 ILTV 바이러스 야외주와 표준주의 UL54 영역의 염기서열을 비교한 도이다.
이하, 본 발명을 상세히 설명한다.
본 발명은 기탁번호 KCTC 13022BP로 기탁된 전염성 후두기관염 바이러스(Infectious laryngotracheitis virus; ILTV) 약독화주를 제공한다.
상기 약독화된 후두기관염 바이러스는 대전시 유성구 소재 한국생명공학연구원 생물자원센터에 기탁번호 KCTC 13022BP로 2016년 05월 03일, TCO-V1으로 기탁하였다.
상기 전염성 후두기관염 바이러스는 기존 상용 백신주들과 상이한 유전자 패턴을 가지며, 전염성 후두기관염에 걸린 닭, 구체적으로 닭의 호흡기관, 이들의 배설물로부터 분리할 수 있다. 또한, 상기 전염성 후두기관염 바이러스는 서열번호 15로 기재되는 염기서열을 가진다.
상기 약독화주 또는 약독화된 바이러스는 동물에 투여되었을 때 질병의 임상적 증상이 없거나 감소되었음을 보여주는 바이러스를 의미하는 것으로, 본 발명의 약독화주는 당업계에 알려져 있는 방법, 예를 들어, 바이러스의 계대배양을 통해 분리될 수 있고, 세포주계대를 통해 약독화시키는 것이 바람직하고, 닭(Gallus gallus) 유래 간세포(LMH cell)에서 20 내지 40회 수행하여 약독화 시키는 것이 보다 바람직하다.
또한, 본 발명은 본 발명의 전염성 후두기관염 바이러스 약독화주를 포함하는 가금류 전염성 후두기관염 예방용 백신 조성물을 제공한다.
상기 전염성 후두기관염 바이러스는 주로 닭에 감염되는 바이러스로, 다른 가금류에서는 발병하지 않으나, 이들에 의해 바이러스가 전파될 수 있으므로, 상기 조성물은 닭(육계, 산란계), 칠면조, 오리, 거위 및 메추리로 구성된 군으로부터 선택되는 어느 하나의 가금류에 사용될 수 있다.
상기 백신 조성물은 동물에서 면역학적 반응을 유도하는 적어도 하나의 면역학적으로 활성인 성분을 함유하는 조성물을 의미하는 것으로, 본 발명의 약독화주를 이용한 생독 및 사독 예방 백신뿐만 아니라, 약독화된 ILTV의 유전자를 사용하여 생산한 ILTV 서브유니트(subunit) 백신, 벡터(vector) 백신, 키메라(chimera) 백신, DNA 백신 등과 같은 다양한 형태로 제조될 수 있다.
상기 백신은 당업계에 알려진 임의의 형태, 예를 들면, 액제 및 주사제의 형태 또는 현탁액에 적합한 고체 형태일 수 있으나, 이에 한정되는 것은 아니다. 이러한 제제는 또한 리포좀이나 가용 유리 내로 유화 또는 캡슐화되거나 에어로졸이나 스프레이 형태로도 제조될 수 있다. 이들은 경피(transdermal) 팻치에 함유시킬 수도 있다. 액제 또는 주사제의 경우, 필요시 프로필렌 글리콜 및 용혈 현상을 방지하는데 충분한 양 (예: 약 1%)의 염화나트륨을 함유할 수 있다.
본 발명의 백신은 추가로 수의학적으로 허용 가능한 담체 또는 희석제를 포함할 수 있다. 상기에서 "수의학적으로 허용 가능한" 이란 생리학적으로 허용되고 닭에게 투여될 때, 활성성분의 작용을 저해하지 않으며 통상적으로 위장 장애, 현기증과 같은 알레르기 반응 또는 이와 유사한 반응을 일으키지 않는 비독성의 조성물을 말한다.
백신에 적합한 담체는 기술분야의 당업자에게 공지되어 있으며, 단백질, 당 등을 포함하지만, 이에 한정되는 것은 아니다. 상기의 담체는 수용액, 또는 비-수용액, 현탁액 또는 에멀젼일 수 있다. 면역원성을 증가시키기 위한 면역보조제로서 정형 또는 비정형 유기 또는 무기 고분자 등이 사용될 수 있다. 면역보조제는 일반적으로 항원에 대한 화학적 물리적 결합을 통해 면역반응을 촉진시키는 역할을 하는 것으로 알려져 있다. 구체적으로 면역보조제로서는 비정형 알루미늄 겔, 오일 에멀젼, 또는 이중 오일 에멀젼 그리고 이뮤노졸 등이 사용될 수 있다. 또한, 면역반응의 촉진을 위해 다양한 식물 유래 사포닌, 레바미솔, CpG 다이뉴클레오티드, RNA, DNA, LPS, 다양한 종류의 싸이토카인 등이 사용될 수 있고, 위와 같은 면역 조성물은 다양한 보조제와 면역반응 촉진 첨가물의 조합에 의해 최적의 면역반응 유도를 위한 조성으로 사용될 수 있다. 또한, 백신에 추가될 있는 조성물로는 안정제, 불활화제, 항생제, 보존제, 등이 사용될 수 있다. 백신의 투여 경로에 따라 백신 항원은 증류수, 완충용액 등과도 혼합하여 사용될 수 있다.
상기 백신은 접안, 경구, 근육, 피하, 등의 투여경로를 통해 투여될 수 있으나 이에 한정되지 않는다.
또한, 본 발명은 수의학적으로 허용가능한 양의 본 발명의 백신 조성물을 가금류에게 투여하는 단계를 포함하는 보호성 면역 반응 유도방법을 제공한다.
아울러, 본 발명은 수의학적으로 허용가능한 양의 본 발명의 백신 조성물을 가금류에게 투여하는 단계를 포함하는 가금류의 면역반응을 증가시키는 방법을 제공한다.
상기 면역 반응은 백신 조성물 또는 이를 포함하는 백신 중에 포함된 항원 또는 항원들에 대해 특이적으로 지시된 항체, B 세포, 헬퍼 T 세포, 서프레서 T 세포, 세포독성 T 세포 및 감마-델타 T 세포의 생산 또는 활성화, 숙주에서 치료학적 또는 보호 면역학적 반응을 나타내어 새로운 감염에 대한 내성이 증진되거나 질환의 임상적 중증도가 감소되는 효과 중 하나 이상을 포함하지만 이에 제한되지는 않는다. 바람직하게는 보호 면역 반응일 수 있다.
상기 보호는 감염된 숙주가 통상적으로 나타내는 임상적 징후의 감소 또는 부재, 보다 신속한 회복 시간 또는 보다 낮아진 지속시간 또는 감염된 숙주의 조직 또는 체액 또는 배설물에서 보다 낮은 바이러스 역가에 의해 입증된다.
상기에서 유효량은 면역 반응을 유도하여 닭에서 닭 전염성 후두기관염 바이러스 감염의 빈도수 또는 이의 중증도를 감소시킬 수 있는 백신의 양을 의미하며, 당업자라면 적절하게 선택할 수 있다. 예를 들면, 유효량은 상기 생백신 조성물을 포함하는 백신일 경우 본 발명의 약독화 바이러스를 104.0 EID50/마리 포함되는 것이 바람직하다.
본 발명의 구체적인 실시예에서 본 발명자들은 닭 전염성 후두기관염(Infectious laryngotracheitis; ILT) 바이러스에 대한 백신 후보주 선별하기 위하여, 새로운 유전자 결정법을 확립한 후, 야외주로부터 상용 백신주와 유전형 패턴이 상이한 30678/14를 백신후보주로 선별하였다(도 1 참조).
또한, 본 발명자들은 상기 선별한 바이러스를 생산하기 위하여 닭(Gallus gallus) 유래 간세포(LMH cell; ATCC CRL2117)를 배양한 다음, 이를 이용하여 선별한 바이러스를 생산하였다(도 2 참조).
또한, 본 발명자들은 선별된 백신 후보주의 Plaque Purification를 수행한 후, LMH세포에서 30번 계대배양을 통해 약독화주를 제조한 결과, 20계대의 Plaque이 1계대의 Plaque보다 크기가 작게 발생되는 것을 확인했으며, 20계대로 약독화 시킨 바이러스와 상용백신인 Nobilis ILT(serva)백신의 Plqaue 크기가 비슷한 것을 확인하였다(도 4 및 도 5 참조). 또한, 계대수 별 CPE의 양상을 1계대와 30계대를 사용하여 비교한 결과, 계대배양이 이루어지지 않은 1계대보다 30계대 Plaque의 크기가 작게 확인되었고, Nobilis ILT(serva)의 Plaque과 비교하였을 때 비슷한 것을 확인함으로써 약독화 진행이 되었음을 확인하였다(도 6 참조). 이에, 본 발명자들은 상기 약독화 백신을 대전시 유성구 소재 한국생명공학연구원 생물자원센터에 기탁번호 KCTC 13022BP로 2016년 05월 03일, TCO-V1으로 기탁하였다.
또한, 본 발명자들은 SPF 종란을 이용하여 약독화를 확인한 결과, 계대를 진행하지 않은 바이러스가 매우 크고 두꺼운 Pock를 CAM에서 형성하는 것과 달리 30 계대까지 약독화시킨 바이러스 샘플에는 매우 작은 크기의 Pock를 형성하는 약독화된 바이러스가 포함되어 있음을 확인하였고(도 7), 이는 기존 백신과 유사한 Pock의 크기를 나타냄을 확인하였다(도 8 참조).
또한, 본 발명자들은 본 발명의 약독화주의 안정성 및 효능을 평가한 결과, 본 발명의 약독화 백신, 또는 Nobilis ILT(serva)을 처리한 후, 공격 접종된 군은 유의적인 증체량 및 임상증상의 변화가 없었고(도 9 및 도 10 참조), 동물모델 실험을 통해 유의적인 ILTV 예방 효과를 나타냄을 확인하였다(도 11 참조).
따라서, 본 발명의 전염성 후두기관염 바이러스(Infectious laryngotracheitis virus; ILTV) 약독화주는 상용 백신주들과 상이한 유전자 패턴을 갖는 닭 전염성 후두기관염 바이러스에 유의적인 예방 효과를 나타내고, 동물모델 실험에서 우수한 안전성을 입증되었으므로, 양계 농장에 심각한 피해를 일으키는 전염성 후두기관염 바이러스의 유전적 변이에 따른 새로운 변종에 대한 유의적인 감염 예방 백신으로 사용될 수 있다.
이하 본 발명을 실시예 및 실험예에 의해 상세히 설명한다.
단, 하기 실시예 및 실험예는 본 발명을 예시하는 것일 뿐, 본 발명의 내용이 하기 실시예 및 실험예에 한정되는 것은 아니다.
< 실시예 1> 닭 전염성 후두기관염 (Infectious laryngotracheitis ; ILT ) 바이러스에 대한 백신 후보 주 선별
본 발명은 선행 연구로써 병성감정을 통하여 10주의 ILTV(ILT VIRUS) 야외주를 확보하였으며, 이들의 유전자형을 전장 유전체의 6부분을 증폭할 수 있는 하기 표 1에 개시된 프라이머를 이용하여 유전자형을 결정하였다. 상기 유전자형의 결정은 기존에 알려져 있던 바이러스 전장 유전체의 염기서열을 분석해, 6개의 PCR 타겟 부분 염기서열을 확보하고 이를 비교분석하는 방법으로, ILTV 표준주(Nobilis ILT(Serva); ncbi accession number: HQ630064)의 각 부위에 하나의 염기서열 차이라도 있으면 서로 다른 유전자형을 알파벳으로 부여하고, 여섯 개의 알파벳의 조합으로 바이러스의 유전자형을 결정하였다.
구체적으로, 본 발명의 유전자형 결정법은 기존의 PCR-RFLP법의 한계를 극복하여 16개의 ILTV주를 14개의 유전자형으로 분류할 수 있다. 상기 ILTV 야외주 10개 중 종란 및 조직에서 배양이 용이하며 증식률이 높은 6종의 ILTV 주를 선별한 다음, 선별된 6개의 ILTV의 유전자형을 판별하기 위하여 바이러스 샘플로부터 Viral DNA extraction kit을 사용해 바이러스 DNA를 추출한 후, 하기 표 1에 개시된 프라이머를 사용하여 각각의 목적 유전자 부위를 PCR로 증폭하였다. PCR 조건은 95℃ 5분 후, 95℃ 30초, 60℃ 30초, 72℃ 30초를 35번 반복하였다. 그 후 마지막 증폭으로 72℃에서 5분을 반응하였다. 그 PCR 산물의 염기서열을 Sanger법으로 분석한 후 얻어진 염기서열을 기존에 알려진 표준 염기서열과 함께 ClustalW를 사용해 Alignment를 실시하였다. 표준 염기서열과 비교분석하여 같은 염기서열을 보이는 표준 염기서열의 유전자형을 바이러스 샘플에 부여하였다. 만약 샘플의 염기서열이 표준 염기서열과 정확히 일치하지 않고 하나의 다른 염기서열이라도 갖고 있다면 그 염기서열에 새로운 유전자형을 부여하고 이를 표준 염기서열에 추가하였다. 여섯 개의 유전자형의 조합을 통해 샘플에 존재하는 바이러스의 유전자형을 분류하였다.
그 결과, 도 1에 나타낸 바와 같이, 유전자형의 패턴이 상용 백신주들과 다른 야외주를 선정하는 것이 중요하므로, 유전자형 패턴 결과 중 상용 백신주들과 가장 다른 패턴을 보인 30678/14 또는 12/07이 최종 백신 후보주로 선발되었으며, 이 두 개의 후보주 중 최근 양계농장에서 피해가 심했던 야외 분리주인 30678/14로 최종 백신 후보주를 선발하였다(도 1).
아울러, 본 발명에서 선정한 야외주와 표준주의 6개 타겟부위에 대한 염기서열 분석결과를 도 14 내지 도 20에 나타내었고(도 14 내지 도 20), 전장 유전체 염기서열 분석을 통해, 본 발명에서 선정한 30678/14주의 염기서열을 서열번호 15에 기재하였다.
Name 서열(5′-3′) 서열번호 Expected size of PCR product
UL54-F CACAATGTTCTGGCCGGGTC 1 544 bp
UL54-R GTGATGATATCGATCGTGATAGAG 2
UL52-F CTATTACTGGCAACATGGCCTG 3 473 bp
UL52-R CTTGGCTGACATGCTGGTCAG 4
UL27-F CTCTGGTGGCAAGTATCCTG 5 638 bp
UL27-R CAGACGGTACTTTCTGTTGG 6
UL36-F CGATCGAAGAAGTTTTGTGCC 7 627 bp
UL36-R GAGACGGCGAAAGCAAATGG 8
ICP4-F CAAGTTTTTGCCATGGGGAC 9 603 bp
ICP4-R CATGACAGGCGCAAAAGAC 10
US5-F GAAACACACTTTTTCACTCAGGC 11 367 bp
US5-R CATGGAATTCTGAAACAACAGTAGG 12
< 실시예 2> 바이러스 배양을 위한 닭 유래 세포 배양
상기 <실시예 1>에서 선별한 닭 전염성 후두기관염 바이러스(Infectious laryngotracheitis; ILT)를 생산하기 위하여 닭(Gallus gallus) 유래 간세포(LMH cell; ATCC CRL2117)를 준비하였다.
구체적으로, 0.1% 젤라틴(약 10 내지 15 ml)을 첨가하여 37℃에서 10분간 두어 175T 플라스크를 코팅하였다. 한편, 10% FBS가 포함된 DMEM(Dulbeccos Modified Eagles Medium) 배지로 배양한 LMH 세포에 0.1% 트립신-EDTA를 10 ml 첨가하고 37℃에서 2분 동안 반응시켜 부착된 세포를 떼었다. 떼어낸 세포를 50 ml 튜브로 옮기고 1,200 내지 1,500 rpm으로 3분 동안 원심분리하여 상층액을 제거하였다. 여기에 1 내지 2 ml의 FBS를 첨가하여 세포와 잘 섞어주고, 이를 다시 상기와 동일한 조건으로 원심분리하여 세포 펠렛을 수득하였다. 수득된 펠렛에 10% FBS가 포함된 배지를 5 ml 첨가하고, 세포와 잘 섞은 뒤, 여기에 배지를 25 내지 30 ml 더 첨가하고 세포와 잘 섞었다. 상기 젤라틴으로 코팅한 175T 플라스크를 3회 세척하고, 상기 세포를 넣어 37℃, 5% CO2 조건하에서 배양하였다. 상기 세포는 필요에 따라 계수하였다.
< 실시예 3> 닭 전염성 후두기관염 바이러스의 배양
상기 <실시예 1>에서 선별한 바이러스를 상기 <실시예 2>에서 배양한 세포를 이용하여 ILTV를 생산하였다.
구체적으로, 상기 <실시예 2>에서 배양한 세포가 플라스크에 80% 이상 채워졌을 때, 배지를 제거하고, PBS로 2번 세척하였다. 그런 다음, 3 ml의 바이러스를 넣고 가볍게 흔들어 준 다음, 이를 37℃ CO2 배양기에서 15분 간격으로 5분씩 흔들어주며 1시간 동안 배양하였다. 그 후, 바이러스가 포함된 배양 배지를 제거하고, 10% FBS가 포함된 DMEM 배지를 30 ml 첨가하여 3 내지 5일 동안 배양하였다.
그 결과, 도 2에 나타낸 바와 같이, 본 발명의 바이러스가 감염된 세포에서 CPE(Cytopathic effect)가 형성되는 것을 확인하였다(도 2).
< 실시예 4> 선별된 백신 후보주의 Plaque Purification
상기 <실시예 1>에서 선별한 30678/14를 순수분리하기 위해 Plaque purification을 수행하였다. Plaque picking은 10진 희석하여 접종된 배수 중 10-3에서 얻은 plaque를 사용하였으며, 세포의 준비 및 바이러스의 생산은 상기 <실시예 2> 및 <실시예 3>과 동일한 방법으로 3번 수행하였다(도 3).
< 실시예 5> 약독화 백신 제조
선별한 야외주의 약독화된 세포주유래(Tissue Culture Origin, TCO) 백신 개발을 위해 닭 유래 세포인 LMH세포에서 30번 계대배양을 진행하였다.
구체적으로 약독화 실험은 상기 <실시예 4>에서 수득한 야외분리주가 175T flask에서 전체적으로 CPE를 생성하는 시기에 수거하여 계대배양을 시키는 방법으로 30 계대수까지 약독화를 진행하였다. 약독화 진행을 하면서 Plaque assay를 하여 계대수 별 약독화 진행 여부를 확인하였다. 이는 약독화진행 계대수 1계대와 20계대의 Plaque의 양상을 비교함으로써 알 수 있다. 또한, 20계대 야외주의 약독화를 비교하기 위해 ILT 상용백신 Nobilis ILT(serva)의 Plaque도 함께 비교하였다.
그 결과, 도 4 및 도 5에 나타낸 바와 같이, 20계대의 Plaque이 1계대의 Plaque보다 크기가 작게 발생되는 것을 확인했으며 PFU는 1계대에서 2×106 PFU/ml, 20계대에서 9.2×105 PFU/ml임을 확인하였다. 또한, 20계대로 약독화 시킨 바이러스와 Nobilis ILT(serva)백신의 Plqaue 크기가 비슷한 것을 확인하였다(도 4 및 도 5).
또한, 계대수 별 CPE의 양상을 1계대와 30계대를 사용하여 비교한 결과, 도 6에 나타낸 바와 같이, 계대배양이 이루어지지 않은 1계대보다 30계대 Plaque의 크기가 작게 확인되었고, Nobilis ILT(serva)의 Plaque과 비교하였을 때 비슷한 것을 확인함으로써 약독화 진행이 되고 있음을 확인하였다.
아울러, 상기 약독화된 후두기관염 바이러스는 대전시 유성구 소재 한국생명공학연구원 생물자원센터에 기탁번호 KCTC 13022BP로 2016년 05월 03일, TCO-V1으로 기탁하였다.
< 실험예 1> 특정병원체부재 (specific pathogen free; SPF) 종란에서 약독화 확인
SPF 종란에서 본 발명의 바이러스의 약독화 여부를 확인하기 위하여, 30계대까지 약독화시킨 바이러스 및 대조군으로 1계대한 바이러스를 CAM(chorioallantoic membrane)에 각각 접종한 후, 1 계대 및 30 계대의 Pock size를 비교하였다. 또한, 30번 계대 된 바이러스 샘플에서 현저하게 작은 크기의 Pock를 purification한 후, Nobilis ILT(serva)와 비교하여 약독화 여부를 확인하였다.
그 결과, 도 7 및 도 8에 나타낸 바와 같이, 계대를 진행하지 않은 바이러스가 매우 크고 두꺼운 Pock를 CAM에서 형성하는 것과 달리 30 계대까지 약독화시킨 바이러스 샘플에는 매우 작은 크기의 Pock를 형성하는 약독화된 바이러스가 포함되어 있음을 확인하였고(도 7), 이는 기존 백신과 유사한 Pock의 크기를 나타냄을 확인하였다(도 8).
< 실험예 2> 동물모델에서 안정성 평가
<2-1> 증체량 변화 확인
농림수산검역검사본부 고시 국가검정 동물용의약품 검정기준에 의거한 닭 전염성 후두기관염 바이러스의 안전성 및 효력평가를 시험하였다.
구체적으로, 닭 전염성 후두기관염 바이러스에 감수성이 있는 6~8주령의 닭을 사용하였으며, 시험군 별로 10마리씩을 사용하였다. 시험군에 백신의 1수분을 점안접종으로 본 발명의 약독화 백신을 접종하고 2주간 관찰하였다. 백신접종 후 2주 후 시험군 및 대조군에 공격용 바이러스(본 발명에서 선정한 30678/14 야외주)를 0.1 ml (104.0 EID50/마리)씩 기관내에 접종하고 14일간 이상 유무를 관찰하였다. 또한 공격 접종 후, 각 군의 증체량의 변화를 확인하였다(음성 대조군은 백신 및 공격용 바이러스를 모두 미처리한 군이고, 양성 대조군은 닭 전염성 후두기관염 바이러스만을 처리한 군).
그 결과, 도 9에 나타낸 바와 같이, 본 발명의 약독화 백신, 및 Nobilis ILT(serva)을 처리한 후, 공격 접종된 군은 유의적인 증체량의 변화가 없었으나, 대조군은 유의적인 증체량 감소를 나타냄으로써, 본 발명의 약독화된 백신은 동물모델에서 안정성을 나타냄을 확인하였다(도 9).
<2-2> 임상 증상 확인
상기 실험예 <2-1>과 동일한 방법으로 실험을 수행한 후, 임상증상을 각 시험 군별 관찰하였다. 각 시험군 별 임상증상평가는 육안으로 관찰하였고 개구호흡, 기침, 눈부음, 목털음, 피가래의 임상증상을 보이는 개체들을 조사하였다.
그 결과 도 10 및 하기 표 2에 나타낸 바와 같이, 양성 대조군의 개체들은 대부분 개체에서 임상증상을 나타내었으나, 본 발명의 약독화 백신을 처리한 군은 한 개체의 눈 부음 증상을 제외한 모든 개체가 양호한 상태를 나타냄을 관찰되었고, 기 개발 백신 군에서도 눈 부음 증상을 보이는 두 마리 개체를 제외하고는 양호한 임상 증상을 나타냄을 확인하였다(도 10 및 표 2).
Figure 112016092355713-pat00001
< 실험예 3> 동물모델에서 약독화 백신의 효력 평가
<3-1> 바이러스 량의 변화 확인
본 발명의 약독화 백신의 효력확인을 위하여, 7일 간격으로 확보한 점안 샘플링의 샘플들의 DNA를 추출하고 바이러스의 량을 분석하였다.
구체적으로, 호흡기 샘플의 DNA 추출은 DNA extraction kit(Bioneer,Cat.K 4472) 사용하여 추출하였다. 추출한 바이러스의 DNA으로 각 군별 각 개체의 바이러스 량 분석을 시험하였다. 바이러스 량은 real time PCR을 통해 정량 분석을 진행하였다. 사용된 프라이머는 UL15a-F(5'-TTGCTGTGCTATTTCGCGTG-3'; 서열번호 13), UL15a-R(5'-GTAAATCGTTTAGTGCGGCAT-3'; 서열번호 14)이며 SYBR green PCR premix(Takara, Cat.RR420A)으로 real time PCR을 진행하였다(A Mahmoudian, 2011 - Taylor & Francis).
그 결과, 도 11에 나타낸 바와 같이, 본 발명의 약독화 백신을 처리하고, 공격용 바이러스를 처리한 군은 바이러스의 양의 변화가 미비하였으나, 공격용 바이러스만을 처리한 양성대조군은 바이러스 양이 21일째 현저히 증가하는 것을 확인하였다. 따라서, 본 발명의 약독화 백신은 유의적인 백신 효력을 나타냄을 확인하였다(도 11).
<3-2> 조직병변 및 섬모소실지수 평가
상기 <실험예 2>에 실험 종료 후, 각 군의 개체들을 부검하여 기관의 H&E 조직염색을 통해 조직병변 및 섬모소실지수를 평가하였다.
그 결과, 도 12 및 도 13에 나타낸 바와 같이, 본 발명의 약독화 백신을 처리한 군은 미약한 염증세포의 침윤 및 cilia의 약한 손상만을 보이므로, 유의적인 백신 활성을 나타냄을 확인하였다(도 12 및 도 13).
한국생명공학연구원 KCTC13022BP 20160503
SEQUENCE LISTING <110> University-Industry Cooperation Foundation, Konkuk University Lee, Sang Won <120> An attenuated chicken Infectious laryngotracheitis virus, and vaccine composition comprising the same <130> P2016-239 <150> KR10-2016-0064869 <151> 2016-05-26 <160> 15 <170> PatentIn version 3.2 <210> 1 <211> 20 <212> DNA <213> Artificial <220> <223> UL54-F <400> 1 cacaatgttc tggccgggtc 20 <210> 2 <211> 24 <212> DNA <213> Artificial <220> <223> UL54-R <400> 2 gtgatgatat cgatcgtgat agag 24 <210> 3 <211> 22 <212> DNA <213> Artificial <220> <223> UL52-F <400> 3 ctattactgg caacatggcc tg 22 <210> 4 <211> 21 <212> DNA <213> Artificial <220> <223> UL52-R <400> 4 cttggctgac atgctggtca g 21 <210> 5 <211> 20 <212> DNA <213> Artificial <220> <223> UL27-F <400> 5 ctctggtggc aagtatcctg 20 <210> 6 <211> 20 <212> DNA <213> Artificial <220> <223> UL27-R <400> 6 cagacggtac tttctgttgg 20 <210> 7 <211> 21 <212> DNA <213> Artificial <220> <223> UL36-F <400> 7 cgatcgaaga agttttgtgc c 21 <210> 8 <211> 20 <212> DNA <213> Artificial <220> <223> UL36-R <400> 8 gagacggcga aagcaaatgg 20 <210> 9 <211> 20 <212> DNA <213> Artificial <220> <223> ICP4-F <400> 9 caagtttttg ccatggggac 20 <210> 10 <211> 19 <212> DNA <213> Artificial <220> <223> ICP4-R <400> 10 catgacaggc gcaaaagac 19 <210> 11 <211> 23 <212> DNA <213> Artificial <220> <223> US5-F <400> 11 gaaacacact ttttcactca ggc 23 <210> 12 <211> 25 <212> DNA <213> Artificial <220> <223> US5-R <400> 12 catggaattc tgaaacaaca gtagg 25 <210> 13 <211> 20 <212> DNA <213> Artificial <220> <223> UL15a-F <400> 13 ttgctgtgct atttcgcgtg 20 <210> 14 <211> 21 <212> DNA <213> Artificial <220> <223> UL15a-R <400> 14 gtaaatcgtt tagtgcggca t 21 <210> 15 <211> 153658 <212> DNA <213> Infectious laryngotracheitis virus <400> 15 attcgaaacc cctcgcggcc gcgaccgaac ggcgaaaaaa atttcacctc aatagaagcg 60 aacgggcgct ggcgagattc ggccaaaatc ctcggataaa ttttcgcctc gaaatggcgc 120 gtttggcccc ctgccagcgc ggccctgcgt acgtgcgcag caccccctgc cccgcggcaa 180 tcgctcccct actttctgtt ttacttcctt ggtatttcta cgcatcctgt tttccgagaa 240 ccgaggcgtg gtgttgctaa gcagctcctc ggcatccggt ataagcgggc aagcacccag 300 tgcgagcgcc attaaaagcg cggcagcgca cagcagccac gctccctacc tcgctccgct 360 tcttccccgt ctctctccac tgtcctctac tgctgcccct tcccattgac cctttccgct 420 cttccacagg gacgtccact cattggttct ttgttctctc ttacagggtt cgcagtgcgc 480 ttgtctctga cgggaccgcc cgccgttgga tttcgcgagg ctccgcagag gagactgatt 540 ggggaatgat tggtaagctt gtgccaattc cattcctctt tctgtctcca ccgctgtgcc 600 attcgcctct ttccagtggg tctcttccag gtgctaggac gcgacccctg cctaagcgag 660 gctccgcacc ggagactcag gaatggtcat tccattccta tctccctctc cgatgcggcg 720 cccgccgtac cctaccgttc cgctttctgg ttgcgcaaat tgctctggcg gtgagcggcc 780 caaatcctcg gctgaattgc aggctgcaat gacttcctga tttaattaat ttatccggtg 840 attttggccg aatctcgcca gcgcccgttc gcttctattg aggtgaaatt tttttcgccg 900 ttcggtcgcg gccgcgaggg gtttcgaata ggatcagaga ccgcctccaa tccctctcgc 960 ccccgcgctt ggctctgtgc cgcacacccc accctcctcg ccgagcggct gccaccattc 1020 cctctctccg atagatccga tgcctctggg ggtccgtgcc aggccggtct gatctgtgct 1080 ttaacgctga cagccgagaa tgtgcacgaa gccgccgggt tggcatatac ctccgcggtc 1140 cgctgcgcct tcccccccac cccccttcag ccgccacgct atccaagctc tccgaggtat 1200 ctgggtgccg ccagggttcc tccgcatgta ctgagatccc tgaggggcct acccagatct 1260 tcggagcctt ggcttaccga cggcgcgccc tgctctccag cagcttttaa gccccctact 1320 tgctgagagg tggcccgcgc ttgctttccg ctcaactgcc ttttagctcc acagctctaa 1380 accccggttc tacgatacta gccgcggaag gctgtgcgat aggagccgag tacacttaag 1440 tttatccgct cctatgcagt agcctccgca agctagcgtg tagatactcc atcgatgcgg 1500 gacagcaaag gtgcaggacg gcaggacggc aacatttgac tggcaggtag taccgttgtg 1560 gaaaagccgt actgcccgct cccgccggag accaagttac tgcgtttaga gctatcttgt 1620 ctctgggtgg gttcggagag tgcgggattt tcgggcatct agtctctggc cagtcgagga 1680 tggtccatcc agctgtcgtg tatgtatagc gagcaatgac cgtgtggttc cctcatcacg 1740 gagtgctcgt tatgcataga tgcctgcggg ctaggtcaca cttgctgggc agcggctaaa 1800 ctggctagcc tgcaaatagc cctccgacct ctcaggcgac cctcacttag ggtcattgtc 1860 ggagcttttc ggcacaaagt acaagcccat tcactcgccc tctgctaaac tcaccagttt 1920 gctagccagt aacggttagt ttaacagtgg gcgcatgaaa gggctacact gtaatccata 1980 cattcctttt taggatttgc atattccttt gcctgtgata ccgttaccgc cgaaggtagg 2040 tctagggtgt ggatacttct tgacctctct ttcggccgtc acagtatctt ctggatatcc 2100 tcctcagcca tctcgacggc gggcttccca gcggccggta ttcctaacca tgtctttgac 2160 gtagggaaat ccggtgataa aaagttgacc ggtccctgct ccaaaggcac cgttgtggag 2220 cctgcgatac tgcactctct ctagtctagc ctccagcgcc gtggattggg atgcgggata 2280 tctgcacgag gtcactcttt cctaatagtc atcgcatact ttctctgggt aactgacctt 2340 cacagaaagt acgcgatggc agaaggaaag tctggtaacc gcactttttt attttttata 2400 aatcttcggt cagatgtgct tcaaactgat cccagtgaaa tgttgcggta gagactcagt 2460 ggatctggac ggctcagtga aaaccctaca ctgatctgtc caggtgcact gaagttcgac 2520 tcgcatgtct ccgtgggtag tatatatttt cccctgaaca gtggccagtg tatacacttt 2580 tcaatatact cctctgttca gtgggtaata cattttaccc tgttttaccc tgtcggctgt 2640 tgtgtttaca gagttcctta acgtgactgg cgtacctctc cattgcgagt tgttggcagc 2700 tgtgactggg gatgcagttt taatctagtc atatgtctcc caagtcacag gaacttaaca 2760 attcgatcat acaactgcta tacagaacga gagcaagtgc tattcgtgtc aatgcagttt 2820 cgcgttttca ttacaaagac gtgacagtgc gttgacagga agtgttctgc tttctcgcgt 2880 cgcctgcagt ttggctccat catcgggccc gatttacctt aaggtaaacg gtcgaggttc 2940 tggttatagt gctcaaacct caaaagttag ggaagttttc agcacaataa ccaagaatct 3000 tgctcgtact gcacgagcgg aacaatggcc tacaaaggtc gctgcggcct gaagactacg 3060 tgacttgcca gcatcggaaa tcttccatac agtgtaagca caggccgcga gctatgtttt 3120 aataaaaaaa caaacttttg aaagcactaa gtttgtgttg agttttactt cctggcggta 3180 ttgtgtgtat gcctgtgatg tatgcacctc ctgacaagtg atcactaaga tgatagcttt 3240 aatcccgaat ttggacccca agcaggcata taaattttaa gggtgggaaa ctctgtaaac 3300 tttattgcgc aggccacaat tactgacttg ttctaggcct agggttgcgg ggggttatgg 3360 agttcacggt ttcctcgttg gaaaccttac aaaagttgag ggacataatc acacccggtg 3420 ggtgctcctt gttttcccat ctcccatggc aggccctgcc ctgtgggcct gcccagtacc 3480 ctgactaatg cctgtgatat tgtgctttga cctcagctgg aaaaagatta ttgtgtactc 3540 gcgtgcacaa gcatgcctga cgattagcat ccagcatatt gggtacttta agcctttata 3600 aacctttata gttccttaga taaatattgt gtagtcgcct atttattctt ctacttaact 3660 gcggcactgc taggggcgcc actcagtccc tgcaagtctc taaaggcatc aatgatctgg 3720 catgacagca ctgcgctgcc agttctgcat gtttaacccg cccagctcct atgcttaggt 3780 tgtcaaatcc ggatgagtaa aagaacacgg tgcagcgcga cctgtcagtt ttgcattgtt 3840 aattaaaacg gtgatggacg taattactca tcgcgcaaaa catgccatgc atgaaatcaa 3900 cggtttccag tagttctggc cgtgtcagtt tcaattagct tccccaacct ttcaatcttg 3960 tgcggtggga ttcgataaaa atgccggaat ttaaactaga acaaagcccc atatcataga 4020 ccagctggaa gtagtcagtt gccgtagaat aagatgctcc taacattact ttcaggctaa 4080 ttgggagaaa gcatgttgga atttcaggaa ttgggtctgt ccagtcggtc cttggagtcg 4140 gacacaggac aggccttgcg tccttacact tccagatatg atgtaatatt gcaaggcata 4200 ccaaaacata taatacagtc catatttaac taatgatgat aagatggttg caacaatgtc 4260 gctgacctgc attctacagg tgacattatg tcaagacgca cgtggtatct tctagtactt 4320 gtatatggag tgttcaaaga attaagaagt cgcctaaggc gacttccact gaccggccta 4380 gcctttttag ggaagctacc ccttcctaat ggacattggg gaagcagagt gaacaattga 4440 aaagtggcat gaatgactta gcattccaag ttcactgctg cacacaacat gctagttcga 4500 tcatgcactc gcaactggta cgagcaacac agttcttgat tggcgttttc gccgtctatg 4560 ggtggaaaga aaagcatgtt gtgaccactg cgtactacta actaataaaa atgctccatt 4620 taataacaaa tgtgaatagt aaccagtaac agctgtatag tacatcttca caacacctgt 4680 ttaaagtata atttggggtc atccagatat tctaaattta ccaccctgat gcctgtttat 4740 tgtaatgctc actctctgta tcattgagtg tggtatctgc gcctctaaca atgagttggc 4800 gcttgatata aggcattata taaaataatc tcttgattag gccgtgttgc aatcgtaatc 4860 cctggttcca gaacatgctg gagaaacttg gcctctgttt gcactatgtg gtagtaatta 4920 gtatatggat gggagtttgc ggtgttccaa tttatttgtt cagacccaca gcgtacgtgt 4980 aaacccctga caatgcagaa atactgatga tgaactagtg aggtacatct tgacctctga 5040 ctataaagaa atactgatga tgaatgctgt agaacagaac tacatctaga tctgtgtcga 5100 aagacagccc actggcgaag gagtggttgc catttgctgg aaaacatttt caaaatggta 5160 ttttgacaat tggcatcgtg attagagcac gtaacacctt caaatcccac gtatagttca 5220 atggtcattc gtatttcgat gggcatgcgg aagtcggttt gggagtgctg gtttcattgg 5280 ggttattctt gttttgatgg atatgatttg ggagtgttct gaccaactac atatgacgag 5340 aaatgggtac cataaatagg agagggggct taacacaccc attgttaaaa atactcataa 5400 cattacacag ctattattgg agcccacttg acaggccaaa attgtacttc aaaaaagtaa 5460 atcttgatat cctgtatcct cgagcgtgac tatctgtagg agctttgctc catagttatg 5520 ggtgcggaat gtgtcagtat ttagctattg ttatatttac tgggcagggc tcgtttattt 5580 gcccaaattg agcagctcgg actacaatac gacctacaaa gagctgacac agcacagtct 5640 ctaacagctg ttcctggagt catttaaaca gaacgataaa ttcgaactaa atcgggacag 5700 tcccttcgct tgcacggagt ccaggtaaca ctgcggatct gacaatagga ttggtgagaa 5760 caagtgaaga tgccagctcc cgacacgaac tagtgaccta gtccagacga aaatgcttaa 5820 gcttgtcctt gattggacaa gcacgatgaa aacgaaaccc tgcatagata ttggcgagct 5880 ggctctttac acactctgcg gatgtagctt agtgggcggg tatcgggttt cgccgcactg 5940 ccgaacgctg ctttgcttct tgctctatct attttatagc cgggcgcttt taaagaatgg 6000 acttcgagct ttgcatgttc ttaattactt taattctagc aattctttta tttttagcta 6060 tattgtatct acagtgggtc cgtcatcgta gagaagccgc agagaggctg ctatttctgc 6120 ttttaataca caacattcag aacgatgcgg gcttaagacg gaaccgcgcg gcacaaggag 6180 cataactgcg gggtcagtgt ttgttgctgc gtggttgtaa ttctcttttt ggcactgcga 6240 ggctaggttt gttgccgcgc gattgcaggg tttttctttg tgagactggt gatggggaaa 6300 agcttgattg tgcaatagta aaagtgactt aggtacttca tatactgggc tgtggcatgt 6360 aggcacgtcc aagctcggct ctgaattcta agcttgcttt gtcgaaccag ttttgttttc 6420 tttttggggg gagggtagca cactctgccc gagtctcggc attgacttaa cagtgatgtg 6480 aaacccggaa gatcgagcat gaactaatag cattaaagaa ttgttatccg aggaataatc 6540 gtggacgcga atttactcga ccgctaaaat ctttcttcta ctgagctgga tacgtgaaat 6600 ttggtgagta taacctctcg ggatacatag cttttaaata cggggcgtgc aatattaaat 6660 tctgcactcg gggctgcaat ggagcgcgga gctttatttg acaagaccgc caattgcaag 6720 gactgggtct cgatcgggac tactgtgtgg ggcgcgatcg atgcagatga cggggacgac 6780 ttagtctggg attatgaaaa tagcccatat ccaagcatag tttcctcact attcccgggg 6840 gaagaaacgg actcggcaat ttgtaactct gttgttgccg caaacccctg tagcatacct 6900 cctgggcggc agcgtttggc atggccatgc tgctgttttc gtcggccaga cagcttctcc 6960 gtcccgcgcg tggaagttaa tgctcgcctt gttgccgcgg ttgcactgat aattttctca 7020 ttgcttgtag tgatctgtgt tgcgtcatat tgggggtaac atgtcttcag aggacacatc 7080 gggattccta acgccccccg caagtgatga cgacactgac ccttccgagc caccaccaaa 7140 tttatgggat cctcaccagg acgattttcc gagggacgct gattccccaa acccactttt 7200 ctacccctgg gatgactctg tgaataatac tggggatacg ggcagtaacg aagatgacta 7260 tgtagatatg ggaggggtag gtggatccga agactatgaa gacctcggta cgggcgggga 7320 ctctgactat gacaatgtat ctacagcgac cggcgggacg tggtttcctt cccttacttc 7380 ttggtcatca gaggaccacg gcccaacttc tccggaaaac cctatgcaac aacttcaagt 7440 aacaattcag caggattcag atccacagca ggaacccgat ccccagcaag ttcccggtct 7500 ccagcaggaa cctgaccccc agcaagatcc acgagagcct cgtgatcctc ctccctatag 7560 tccgccccca gaggaccctt ttgggctctc gccatttact agtgggatgg gcgggtttgg 7620 gccaccgtgg cggtggcccc agccaccctc gtatgatgag gcaatggggg atggaccttt 7680 tactacgact gggggtcggc gaccttgctc acgcaggcgc ggtcgtcgcc ggtctcgagg 7740 tcgatctcgg cgacgcaatt ggtgtgcagc aaagttgtgc tcagaggcat gtttgtggca 7800 tctcttttgg gttggagtgg ccttaatgtg ttggtggctc ttgtatctta ttttgcgcat 7860 tgtctgggga cagactccgg gataaggaag gttgtatccg catccagtac tcctcaataa 7920 aagcgtggtg gtgctacacg atgtctgtta attttacaac tccattttac aggtgatcta 7980 gagagacgct gagtggcact tgtcccgacg ggaccatgca gtcgaacagc agcgatgagg 8040 cccagtgtga tgatgtcgag gagggatggt cgtccatagc tccaggtgat gcactggata 8100 cagatttcat tccagggcct tgtgccacgt ccatacatgg tatatccaag gcagtttatt 8160 tttttctgtg tggagttaat ctggaggaat gtagtacact cccacagcat gtccaatctc 8220 acccatatgg acatcctgag ctgaaatcag gcaaatggta caagaggttt tgctccgggc 8280 taggcgaaat tggagataca agccagtgtc agctgacacg actatgctgc acttccggaa 8340 tgccggcaca gatttttggg ccttcgagat tcaggtctct gcaacagaag ccaacccata 8400 tgcgggccca agatttgctc actaggcctt gccatatact agagttcgat gttggcgctg 8460 acctaatcaa tcttttcttg tatatggaac catgttcagg gaatcgatat tgcgtacatt 8520 taggatacca taaaactaat gccatgcgtg ttttgagcgg tggtgggatt ctatggggca 8580 gacttccgtg gaaggacaac accgaggagc acgggtactc gttgcctatg cgagtatttg 8640 ggatcaaatt gccccataaa gtttatgtgg catgtcgctg ccctgcaact cggacggaac 8700 tattatttgg tgaggggggg gtaggattca acgcggaaaa ctttaaacag tgcggacggt 8760 tgaaaaaaga gtgtgaatgt ctgcagaagg cttgttttac tgcacaaacg gtgttaggtg 8820 cggcatgtaa gtttactgta tactcgagca agggacgagg tcaagaaatt ctgctatatt 8880 caggacccat gaatgctaca acggtaatgc ctgtagtact gggtatgtta agtagagaac 8940 cccacaggtg tgcaggtaca ctcatactgt ccaggtcctc tggaaattgc cgtggatttc 9000 atgagaccca acacgatatt cccactaacc cgggtctgta tcctctgtgt aatcatgagc 9060 acccttacta tgtgacagtt acagatgtat gcggcaactg ttgttcatgg cttgagcggg 9120 tttttgggag agtagctgcc cctgctggtc taagctccgt atctgtatcc attaaaggct 9180 ccacccacag cgggactgac gtgacagaag aacgtgaaga ggactcaggg acacagcaaa 9240 cctcccacga caaattgccg gagcgcaacc gcatgggaga tcaaaattcg aatttgcggg 9300 gaagagatca atattggccg cctgccccac accgtagtca ttgtcactcg gattttatat 9360 tcgatgaacc tgagccagaa agtggggaag acgtgcataa catgcatcct ccacgaggtg 9420 cagatgagca aacagccgct tctgtgtcag cgctaatgca aagtctagca caagcattgg 9480 tgagtgcaca agctattagc agcatggtct ctggctctgc ttcctcagtg ggcgtagaag 9540 tagactgtgg gtacagtcag actcatatta cagaggggcc ggggagggaa caattcggta 9600 gagtcccaga aagagggcca gagtatcctc aagattactg tgatatatat ggtcctgtaa 9660 gtaatgggcc tgctggatac agagcaggac caccagatgc tcctagtata caagatagga 9720 ccttcccatg cggcagaaga tgcgacgaag catggcttgc cttagaagta gggaatatgc 9780 cttggatttc ttctggttca catagtccac cttctcagta tcataaccct tatggttcac 9840 atagtccacc ttcccagtct cataaccctt atggtacata tagtccgcct tctcagtctc 9900 ataaccctta tggctcatat agtccgcctt cccagtatca taacccttgt ggtacatata 9960 gtccgccttc tcagtctcgt aagcatgact attcacctcc atatccgata ctcaaaccaa 10020 agcctcgatt acccccaggc tttgaaaata ctgctgggat gtggcctcga tgtccccctg 10080 ggtttgaggg gcgtccatac aaatctgggg gcatgggtaa ctttcctgga agtgcatgga 10140 cggtaataga tagggggtct aaccaatggc cagcagacgt gcgggggcca ttctcagatc 10200 aacgatgggc ccccacagag catgaaacgc gacgtttttg cgggtattac agctgagctc 10260 tcatcatacc cataactcca ctcataaccc aaggcccata aatccataac tcataacata 10320 aattcatact ttccggtcgt ccagggcacc acgtcatcaa caaggattgc agataaataa 10380 aaatgctcca cgttgtcggt gtccgttgta ttgtattctt tattatacct ccgtaatttt 10440 cgagagtcgg ggaacattct aaaaatttta accgtgcaat actacagtgt atttacaagg 10500 ccggattgca acagtgaact cattacatca ttgagctcgc ggcgccatct gctgaccagt 10560 ccacagagat ggcaatcttc agaaacgtag gatggcacca attccaatac aataccgcca 10620 tctgtcgata ggtgtataga actgtcaaaa caagtcgcaa gagaaaaatt tccctactgt 10680 atactggcgg cttagcagct gcgcacaaac cactctgcat tcctctttgc ggcacacatt 10740 tgcgtgctgc gccagaacga gtgggatttt tttagaacag gtcccaggat agtacatgtc 10800 ccacaatgtt ctggccgggt ctattgcttt atgattcatg accatggcct ctggtcgcgg 10860 atacacaatt cttgagaacc ggtcgaagaa ggtcagtaat aaagttaaag gacattttgc 10920 gctactcagc gatagctcct gagatctagt ggtatctctt agttgactgc caatgctaga 10980 gagataacac ggcaggattg gccccagatg catggctaga gattgacatg cgcagtagat 11040 gttagagaag ataggatcgt gggggtaaat cctttcatct tcgaactgat gccaaagcat 11100 ccatacaagt gtctcatcgc atgcaaaaag tagctcttca aatgagcagt tcgccaaata 11160 tacagctcgt gaaatttttg ccaacctggc tatatccgga cgcgatgtcc agcggccttt 11220 cagtgaagct gcgcgcccac aaaactgctt ccacgaagtg aatgcagcat ctgctgcaag 11280 gtcagatgat cccgaagaca aaaatgctgg aaagcagatt cctctatcac gatcgatatc 11340 atcacaatca tcatcatcca ctgcccggtt taccatgtct aaaagacatt tctgattttc 11400 taatcttaac tcttcagtaa tgcactttcc gagaccgcca aatgcagttg cggccttttc 11460 aaaatattgg gccggtgtta cgtttcgcaa ctccttcgtt tcggtccgtg atgacgttgg 11520 gcatcggaca aagtctctcc aaatcggtct tcgaagttca tcccgatttc tttcccaaga 11580 cctgcgcgaa tgcttcaacg aaacagtaaa gataggcgcc ctatatcgct tttctggtgt 11640 acctgcacgg cgcctgggtc taggggggat gcctcttcgg acttggatat gcgcacggcc 11700 tctcataaac ttatttcgag ggctactgac ccgccttatg gaagaccgta cgctcatacc 11760 tgactggttc tcgtaacggg aacgaggctc gccattcgaa tagcgacggc gccccctgtc 11820 acgtgaatca cggactcgtt tccagctacc gcgcccagat gaccgggatc tggagctact 11880 ttctgtagaa tgagatctgc ggcgaataca atgtgcttcg tggcgggatt ctgacctcga 11940 gcgtgaacgg ccatccaggc gatcttttgt cctttccgtt gctgatctcg cttcgctatg 12000 agtacttgta ttggaagatg atctggaacg tgtctcacgc ctatctttat ttattccaga 12060 tttctccggt ctccccatcg cagtcagtgg gttgatgtac cgcgtgcacg tcaaaaaaaa 12120 tgaaaccgca tacacaacgg ttgagacttc tacggactca gaacaggtgt caagctcgga 12180 gcaggtgctg agaggtaagc tgacagtaat ctggcacgct gtttgcgagc taatccactt 12240 ggcttttgaa tggtctgggc cactcccagt atacgtcata acacatacac tggaacccac 12300 aaactacaat tgcggtccag tagttggtgc gaaatattca cgcagacata ataatctgcg 12360 agaacttctg cggatccgac atgtaactta atcccgtaat gtagtgcggc ataccgtcta 12420 aaccgcaaac atccgcttag tagaacacgc cctaaaatca cccacgagta tactttgtac 12480 attctgaccg ccagtagtta ctcctttcaa acaatgatac tcagccgtta gaactagggc 12540 tgtcttcaaa tggaccaaat tcagacacaa taccgcacaa cgtgttttaa cattttattg 12600 ccgttcaagg cccgaacaat ttgttttgta tcttctgttc gtatttaaat gcaattatta 12660 caatgctcgc aatcgcagcc acgcacaatg cacgcaagac taagctcgaa gcaatattgg 12720 caaggcatga agtcaagata ctgggaggtt tcgatgcgga gactttagtc tttgccggag 12780 tcgtgtaagg gatcagtgat aagagttcta gaaccgctga gacaattaca tatacccaag 12840 cactaatttt tacgtgttca tgtaaaatat atgcacacgg atcatagcaa atccgcaatg 12900 tcatggtgga cataataagc gatgctaaat ataaaccgat ctcgagtgtt ttcagtagta 12960 agacccctgg attacagacg caaaatccta gagggtctgc tacgtagttc aagcttttgc 13020 aatctcggag atgttcaaat tccctcaaaa accgttgcat ctttgtgtat ggcacccgta 13080 atatcagcct cgaagtaaac gctgtccagt agttaagatg atatgcatcc atcgcaatgc 13140 gttctcgcgg cagacatagc ccgaacattc gcctctggcg acgggtcagc aagtaacata 13200 tgtacaatac cgtcgaaatg aatgcaactc tgatctggga aaaccatatg taaagcagac 13260 agtctgccac ttccatgacg aatactgttc tttggccggt gggatcaaga cgagaaatga 13320 gtacagtctc attttcaaaa taagctcctt taacacatct cgtctggtgg ttctcgtagt 13380 tgtttagacg ctgtgtatat tttgtgagga cataaactag tgaagaatta aatgtagcgg 13440 ggggttggtg aacaggattg aattcttgct gtccgggcag gagccattta atatttgcga 13500 gtacgtacaa gcagtcgtcc tttgagtcag tggaaatttt agagcataca taccatacca 13560 agaagactat atgtatcgtt ccggttaaaa ttactgccca ttttagacat tctggtcgca 13620 gcattctttg gtcagacgca ctgtaaactg agtttgcagc gtgttgcctc cgcacttagt 13680 cgcaaagcat ttggtctgaa atgccgcgta gggattgccc tgtgagttaa ttgcaaccgc 13740 tacagaagta atgacggtct gggcagcggc acttcgatgc gaatgtttaa ggcaggtaaa 13800 agttgcgcgc cctccgcacc ctcgacgatt tcgtaatagt gatgcggtaa tgcgcgtttt 13860 gagcacccgc acgtctccaa aactaatgtc gctgtattcg tgcgccaacg atggaaaatg 13920 ctcttttatg taatttgtta tggccggcag aacatatgtc gtgagcacaa agactccatc 13980 gatcgtatcc accccggctc ctgtcctgtc ttcgcacggt gctaaattga cacgactgaa 14040 tgcttccgcg aggctaagag acacagccgt ttggggcaag ttgctagagg gttttgaaac 14100 tccccctata acgtcaggag gacacgcgat tcgagtgacg ataatatttg gggtgggatt 14160 gtctggacgg aaagcatgaa aatggaaatt attagggtct ttgtgcgctg ccgcgaaagc 14220 tactttatct gcacagtcag gggggaaaat tataaacggc aggagtctcc cagacatgaa 14280 tccggattca gaaaccttgg caaagaaagg tagccggaga cttcgtcctg gcgagtagat 14340 tccagtgtca ataaagtcat agtctctgat aacatcgtct aaacattcaa tgatttcttc 14400 ctgcagtaaa attacgtgct gagctagctt cgcgatagtt tttactgtct ctagaccaaa 14460 caaagcatat ggggatggga ttgggacgca gactctgaac ccgagctttt ctttgcattt 14520 gcataaggtt gaattggcac gatcccgaaa tacatttaac gcatcctgta agtcttgaac 14580 agagactatg gctccatgtt cactcgcatg ctcatcacac catgacattt cttctaccca 14640 gccgctatcg cagaggtaca tgttctcttc gtcttctatg tcatcagaac atgtattctc 14700 caaaaaatca atatccactg aggaatattg tgcgtcatgg ctctccgggg acgagcagtg 14760 acttttgtaa aagtacacgg gataggtgtc atgactgatt gatgtctccg gaaacaataa 14820 ggctattaat tggatcaatg ccacgcgcac ggcccgcatc gctttatgta aggtcaacat 14880 cgttatgggg ccgtgatcta gcttgagggg tatgtcgata tccagtatca gggattgaat 14940 tgctagagat tcgttaagga cttcattcct attcaggtac atttgtgaca gaccgctgca 15000 agatgcccga attttatttt tcgaactagt tccccatgcg gtttcgttca ttgcactagt 15060 ccaagcaaag tctattactg gcaacatggc ctgatctgcg aggggggcat cactgcgcat 15120 tagtaagcag gagtcgtgta tgctggtgtc agatcttaca tcagcggtta taatcgagtc 15180 ccactcatcg ctggcaatgg ctgcaaaagc ctgtccgtgt ccagccaatg ttactctgta 15240 aacgggacat ggtccgtttc tagctgttgg tggaggaatg cttgtgggtt tcagagaatg 15300 gaataagagt gtcactggtc gctttccgca aataacttga tcagatgaaa cgagataaag 15360 taacctactt aagggagcaa aaatgatatc tcctgtctta cagtattgcc cgtcgcgctc 15420 tcttttttgt gcaagggcgt gtggagcgga agcatcatct ccttcctctt cttcctcttc 15480 ttcctcttct tcctgttcat tgctagatac agtgctcaca tttctgacca gcatgtcagc 15540 caagtgtgcc ccgtagcgac agagagtatc ggaatataga cggtctatac gcgttgatac 15600 atcaaatgcg gaacgacaaa aaccaagaaa attgcgcccc tgtatttcac cgtaagattt 15660 tatagctgca aacttccctg ctactacagc cggcaatttc atgacttgca tagtcacatg 15720 ctgtctgaag tacgaagcaa aattacaaca ttcccttaag cttttaaaaa aatcactttg 15780 agcacgagca gaactcttaa ctggattggt gagattttca gaaagacatt gcaagtgttc 15840 tctaatcacg tttcgtccat atccttcact gtaagctaaa tatacaaatg agatgaagtc 15900 acgagctgga agccgcaggg catgtctata tttgcagata agtgcttcca attgttctga 15960 atagcccctg tcggcgctag tacgtaatct caaatgatct ctgaatagct ttgcagattc 16020 gcgagtggca tagtagctgc tgcaccagaa tttagaaaac gcagagaagg acgttaggcg 16080 cgctatagtc aggttactcc tgttgttgct attctccgtt tgaaatgtaa tgcatagatc 16140 ctttactgtt tgaaggtcaa acgtcccagc aataccatcg tcaggggttg cttctaacaa 16200 gtaatatctc atggctgcaa caagggtaat ttctgacggg ccgaattttg atacgaacca 16260 aaaggggttc gaaaagttcg agttgtaaag cctcctgtat gcggcaatca cccttgactc 16320 atgctgaagc atcaggccct ccagggcagg tcttcctctg ggtagggtcg catgtatggc 16380 agaaaaagga attttgttgg ttgtattttc tgctcggaaa attactccga gtgccgcaat 16440 aatgtccgtg tgcaatgcaa atgtttcctc caaatccatg gtttccagta ataactttgc 16500 atcgattgga aacccttcgg ctaaggcttc tctcatagtt gcggcccctt gaccgacaaa 16560 acgacacaca aacactggtc tagacctctg cctgtacttc tccgctccgg tattagcagg 16620 aaggaagaac gtgattttga gaggggaatc tttgcaaaaa tcttgcgcta gagcgtcaac 16680 atgactaaag gccagaacat aaatttcagg ctgcagggct tggccgagta gaaggtgcag 16740 ggagcatact actggatacc catccgtagc atacaacacg cgaatctctt cgtacgaaac 16800 atcctcacta gggggagcgc cgcagggttc acaatatcca gcttgggaag tctctgtctc 16860 atttagcatt tcgacgagca tccagtcatc tgcctcatac tcccatttgg cgtctgggac 16920 acagtcgaag ttcatgatag caaggaaatg tggcagctac tgaagagcgt gttctgcggc 16980 cggtctaact cagagagtaa atacgaagcc cttccaactg ggcggtgcct gcccgtagat 17040 gatcgaaaag tacagtcggc tgtgaagctt attaaaatct ttatccctaa ctgcttggac 17100 gtcgaagatg tcatcggctc gagggatgaa cttaacaaac tcgctcaggc caggcaaatt 17160 agccgcattc tggcaaaatc ggccgcggct atgcagattg ctaagaatat gagatgcccg 17220 cgaggagcag aggcggtttt gcggcaaacg attgtggaca atgggacggt atttcgttct 17280 ctgtactctg tactagccta cctatatctc tcccctgggg cagacacgga tggactactt 17340 gcacaagtaa ccgctcaaac cgcagacagg acgatgatgc taggtgacat gaccgtgctt 17400 acacatgcaa tgcacgtaga cggaatggat cgtgaccata gctctttgga actactgcgc 17460 atgggtctgg taccaaattc agacctgaaa gatccaatcg agctcgtgcc ggtaattgat 17520 aaactgcctg acaaggtact gttccctgat cccgtaccga cactgccagt tgaaaaccca 17580 cccatggagc gtactagacc tgcaaagaca cgtaaagaac tggttgctgc gagttaagtg 17640 acttctcagc gctttaataa agtatgttta aatttttcaa tgtcagtaca ttatttgccg 17700 gtagatccaa accccccgtc accccgaacc gacaacgtat tgcgttcgtc tactactgag 17760 tttactattt tccagcgaag ggcatctggc tctccgagaa aggtgcttct cttctcagta 17820 actattagct gtgccactcg gtcacctgcg cgaatactgg ccgcttcatc tcgaatgtta 17880 gttagcgaaa atgatatcca atcattatcc tgcacatgta tcgggtcgac taacagtcct 17940 ttcagattca tggaggatct ccctagtatg aatgcgcgcc agagaggtcc gcatgctagt 18000 ttttggggaa gggtaatacg ggtagacgac tttgggagaa ttgttacatc tttagtagct 18060 ctaatatcat agcctccatc tcctggacgt ttgggggcaa agatttcgtt aaacggaaac 18120 agtgcggcag ggcaatctgg atctgatcgc agctcgactg tctgatcttt aacgagcgat 18180 cgtgtagctc cgacgatgat atggtgtcgc acctgggcta caaacttgat gttcgatgcg 18240 ccacaaaaac gattgatatt ttctggcgtc gctccgttca gtataacgat gcgttcattg 18300 caggctgcat cttgctcctg caattcttcg aatgttcttc tgtaaaacgt tgtacatccc 18360 atacaaccaa tgttgcccgg aatagttatt ttcgccctta atatatctgg aggtatactt 18420 aaaagggaac ttatacattt ctcgaaacct tcacccaaat aatcatcttc gccttggaaa 18480 gaatctgcgg tttctaagag taggcgcgcg catcccgtcc cacacttgct aagcatggaa 18540 tcgttagcca actttataac atttagccga gcccttacag tgcctggtgg aaatataaca 18600 tttccgtctc ttgtctctgt gccagtcaaa acattcccgc catcgtttac aagtactacc 18660 agtattccca ataatcctgt atagtctgca tctaccaatc ctggaataat ttgataacat 18720 gcagcatggc cttccacatc actgataacg attccatacc cgactggcaa agaagtccta 18780 atcgcagaat caattcttag gacgggagag tcggtgcgcg ttttcgctat tgttgcttca 18840 acgtttgtaa tgacacattg caaggaatcg aggccaaaaa tgtcccaccc ggatccaatc 18900 tctattaatg catttttttc cgttgtcatt tccatctcca tgcaagttgc ttagacgcca 18960 aaataacacc aaccctttca ggaaatccgc gtagttaaaa tcggcagtag accggtagga 19020 tacaaatagt accgcactgc gcgacttaga ggacccgtga aagagactgc agggcgagct 19080 ctcgcaaaag agcaatgagg ctgccgtggg aaaggagttt tatgctgttg ggagcagtga 19140 tgtatttgct gcatttggca ctagtattcg cgcaaccggg tgtgacacca ggacacggaa 19200 tggagcatgg gtattatgat cttggcgctg gaaatatgct tggagcggaa aattcgatgt 19260 atagcgcgaa catggaacac ttttaccaca gtgcctgctc gtcgcgcgga ttttccttag 19320 taaacggaac agctgcttcc gttttctttt tcattagcct ggcagtggcg ttgattggcc 19380 tgctggccgt gctatataac ggttgtttca acagctttaa aagcagtgtc attagttctc 19440 gatggtagcg cagtatctgc tgtaaagacg aaaacatcgg tggtgggacc atattagctc 19500 gaacactatg tcttactaca aagatctctc ggtggaggcg aagaagtatc acgacgatac 19560 tcgacggagg cgagatacca ccacccgccg ccccaaacca ccccaattcg aacacccctg 19620 gtctgggcga agaacatctc catatctaga tttggataga ggaagcgatt ctgattcttc 19680 agaaggggat tacggccatc catcgcgcgc tcactattcg agagatcata cggcaccgcc 19740 tcaaggccgc cgaagccccc cgatggaaag ttttcgcaaa gaaaccactc caaaggagga 19800 gccccctcaa agtaaaaggg gctggaatcc tgataatcat tgcgctggcc tgatgcgacg 19860 tttaactatc tctaagggat ttggtcctag tgctacaccc tcaggggatg aagacccatg 19920 gcatacttct actattccag caaatcgttc ggccttcgtg caagccgtct ctgtgacggc 19980 aatggcccag gcagaattgg cagcgagaga ggtgtgggac gtaacaaaac cacgcacgaa 20040 tagggagttg agggatatgg tgagagagct agaaatcact ataattatca atccgggtga 20100 atctttatgg tctgttgcca cttcggtggc aagagcaatc aaagaaggaa ccccaataac 20160 ccacgagctt ttgcagaaaa gaccatcaaa gcctccaacc cgccgcaaaa ctgaagatgg 20220 agccagaaag agttcttcaa ggccttctca acccaagcct gagcatttcc cccctccaag 20280 aagaaagaca tccgaacgaa agtactagtt tcgggagtct ttgcattact gtgttcctcg 20340 ccatatttgt atcaataaag tatacttatg attggtaaca tgcgtgtatt gtcatgtgtt 20400 catagactat aaaagcgccg tgatttacat ttctgcgcac actgcgcaga accatggaag 20460 aagaatcttc cactggagcc tttgcactgt atgaagtcga agacttcatc gatgaagtag 20520 aatctggggc tgggaggagg tgcagcgatt ttgaggatga tgcgactgac ctaattgaac 20580 tagaagatct ctattttgat tggttacgga atccaggtcc ccccgcgctg gtcaatgcgc 20640 caaagtacgt taggccttca aaatgttcag catcgtttct cgcaaaaaac gcgctaacgg 20700 agctgcaatt tgccgactgg gacaaaatac agcacgtgtt gaagacgata aacattgata 20760 ttttctcgtg tgtaccagtg ggagaaaatg gtctatgcaa tatggattgg ttttccctcg 20820 atacagaaaa aatatggacg ttaatggatt caggaacacc tgatgttagc ccaaatttgc 20880 tgataacacc tggcccgcca cccgaatgca ttaaaactcc agaagaagct ccagcttatt 20940 ttgaagcaat ctcgaattac tttgaatccg tgttagccgt cagagaagcc gaatatgcaa 21000 aattactggc ggagtacgcg aagtcgctcg ctaaatacat cagacataaa tcaaaaaaag 21060 tagggcgcgg tctgcgagcc ctcgaactgg acacagagga ggccaaaaaa cgatttaccg 21120 ttctaatgaa atccgaatac tacaaaggga tcgaaaaact tctaattata tttctggttc 21180 atttagtgct taacgcgtgt agggatgttg ctcggataat atgggtccaa cagagggact 21240 cctcgtctgt attgcagaag gtaacgtata ggtgggaaag ccaacagcta cactgtattt 21300 ttcaaccatt acttgtttct ccgggtccag tttttttgga caacgacccc ttgcctttac 21360 agactttgca gcatgtaaac tacgtacgat atcttttagg agttccggtg ctaagattct 21420 ccatgataga agaatccccc agtgcacaat atatccctta tgacaaaact gcaccttctg 21480 catatgatgt tttagcgact attgcacgta cttgcctaac ttccagcggc tgttcgcgtg 21540 cttatcacga ccatacctac gcacgcgata acgaaaaacc aaactactcc tcctctcgaa 21600 tcgtcttatt agctgattcc gcccttgata cacctatgcc ctaaacatga ccgcccaggc 21660 tataaaacag atggactggc cagacaacat cattgcagcg atggctgaag gcgatgggtt 21720 tgaagagcgt ctccgcgcta aagcgcggtg ccatcagatg aagaggactc cgattggact 21780 cctccaagta atccttgacg gggcaaggaa aattgatccg aaacggattt tagataattc 21840 ttccccgagc gacttagctg tgttagctga gcgagagcta ccatcctccc tgctaggacc 21900 ggcgcgcgaa gaatacttaa aatttgggga taaaaaactg ccagacaact ttatctcacg 21960 cactgtctcc aatgacacca cggatgagta tagaagaaat cttgacgaag cgtttaaact 22020 ctttattgca cgcagagggg tcactgaaaa atgcgttgcc cgaatgctca gacatctcta 22080 tgccaagcgg ttgtccgtgg ttttggatct cgatgtccca tttggtgaaa aaataaacaa 22140 agcgctttcc gccgatgatc aagattttgt actgaaactg tactactggg ttttcccgga 22200 caaggtctct gcgcctagac ttaaggaacc agaaatgcaa gcttacctgg cttcagtaac 22260 ctatttgtcg cgcaccttta agttcattga aggatacgct tattatatgc gcccccctgg 22320 gccagaactc cattcaacag aaacgaccgc tcgtctagca gccctccttg tatatgtgag 22380 aagcatgtac tgcaaactgg cgtccttatt tgacgcaatc gatgccgctg tgctgcgctc 22440 taaatttaat aggggagctt cggctcaagc tctgactgga atttatggat acacgcgaaa 22500 cgggaaggga actataatgt cgcggtattc ttcggaggcc atgagtgatg aaatcatgtc 22560 tgtgtgtcgc actggttcgg acactttgat agaatcttta cgcaaagctc tggggagatt 22620 gacctacctt attgctaggt gggagctcat ttcggtagag aagaaaaggg acgcaaaaga 22680 ggccgtgacg gcagcgttag cattaagtgg actagttagc ggacatttgg gatacttgct 22740 aaacctaatc tcaatggcat acgttttttg gctccctggg cattatttaa atatgcggtt 22800 aatattggcg ctgagttcca gggaactcct aagccatctt ttggctacaa atccttcttc 22860 attgagggaa gtagccagct gtccgaaaat acttttctac caatctgtag aagaatggag 22920 aggacaggaa agaggaacac agatttggtt ggattatgtt actgtaaggg catggttgga 22980 ttatatcgac actgggatcc ctactattcg ctccgaggaa acaaatgctt ccataaatga 23040 aatttccgag tatctggaac agcgacgctc ggccagtcct actgaatcct ttttatcttc 23100 agatggacca ccaaactcaa gcgcagcatc cctgccccct acacaaggct caatgcaaac 23160 acaaaacagg agacgcgaac gacgcagtaa cagtgtcgtt atccgaaagc cctcccgctc 23220 tgcgcattca aagagtaata ccattcccgt gtttcaggaa acgaccattt cttattcggc 23280 accgaattcc ccgacggatc attacgtagt aatgaattaa gcctgtataa ctgtacagta 23340 aatgcatcgc caatttttat atttacgctc tgaataaata atgacattac attgacgtaa 23400 gatgtacata attcgtattt atttactttc ctcgtagact ccgaaagaca gggcaactct 23460 caatgcctta atataccgca aggcaggcga aatagcaggg gacatgtagc atattactcc 23520 ggcggttcca gaacattgta gattctcgac tagggccacg gacatttttt gcgtgcttag 23580 agatgcggtg gagtcatcat gtatagaatt tatgaagtaa acgttggcgc atttgccgcc 23640 atcatccgcc caccatagtc cttgaggtga agtgctcccg gaccaataaa ataaccggtc 23700 taaaatagtg aggaagccga ttgcttttga agatgaggca attttccccc cgagggcacg 23760 gcaagaaagt ttagcatttt catacgtgtc ttgaggcgga ccacccccgg cccgataaca 23820 tgaatccaga tgttgaatcc agtcgggcgg gcacaatccg ccttcccagg tgctgttcgg 23880 cagtgcaaat gccatgacag tgcttattac aaacataaaa atcagtaatc ctaggaaaat 23940 gccaagcagg attagaagaa tcactttaca cgccttccaa tattgtccgc ctgtattttc 24000 ggggcgcatt gaatgaagct ctccggaagg atggggggaa taggtacttg tcgtagagga 24060 tgaagtagag gaacaaacgc ttggctcatc ttccaaaata gccctgactt cgaagggaag 24120 ttctgccatc attttttcca aatggcttcg ttgatcttca gatggggttt gtgaaattat 24180 aggggggttc aggtagcttc gctgatcttc ggatgagggc tgcaaaatta ctggaaggga 24240 ctggcctgct gctatttcag gcatatctag aaaatccact tgggccgcaa gacgaagcga 24300 gtaacgaggg cgctgcgcgc tcgaatttta aaaagaacaa atgtcatttc tgcgtatagt 24360 ttcggccccg ttatggcgtt aacgtcaata tttcacgtat tatgttattg aaagtggtgt 24420 caaggtcatc acatggtggc gctattgctt aattgcgcga aaaatgtgcg ggcgcgagaa 24480 actggttcat agcactcggt gcgaacgtta cgtatgcagt taccgcccat atcatgtaaa 24540 tcaggtcacg ggactggatt cgtaacctat gattggtgcg gggaggtcta gaacaaacat 24600 tcgcacctca gtattaaaaa tataatatag atatactata tttttaatac tgaggtgcga 24660 atgtttgttc tagacctccc cgcaccaatc ataggttacg aatccagtcc cgtgacctga 24720 tttacatgat atgggcggta actgcatacg taacgttcgc accgcgattt cgagtaaccg 24780 ggagcataaa taccgcgtgc gtttggcact ccgtgcgcaa tatgcgcccg ccactgccga 24840 cgtcagatgc tgttctgatc gaaaggttac aggcgccgga attctgtaca acctaacgta 24900 gggcagggtt ccggcgccat acgggtcgca agaaacaggt acaatcccct ttcccctaat 24960 tcattatgtc aatatttttt aggttgtggg gcggcacatc cggcaggatg tcaatcgaga 25020 tttttgaata caggtgatgg agggagtaac cgacacggtg ctggttttga cggagcgcga 25080 caggctcgcc ctattcggac ccattctgtt tcgaggaggg ggacttacgg cagcccggtg 25140 ggctgtttca gtagatgctg ttctaccgtg gaccgaaaaa accatccccc cgttaaaggg 25200 gtccaagctc atcattgctg gggaacctta cttggggtta acatcatcag atgttctctc 25260 caagtgtgaa gggaaaacat tttttgtgct catcgctgtt ccagcagccc tcggacgctg 25320 gatttgcgcg cccccgccac cgcttctaga gtccgttgca gaaaatgtgc gttgtaaaat 25380 ttcagcaacc ctatccaaag agcatggagc gcccttttgc actgccgtat acattttggg 25440 gtcaactaca caggttcccc ctggctctag cttaggttgg tcttgtgtcg ggcaacctgt 25500 ccttcgggcc cctttaaaag aagctaccaa gcccgacgaa tcgttacaat ctgcagagtg 25560 tgtatttaag tgtccgcttt ttgcggatga gttttcgggg aataacccgt ttgcaattgg 25620 gtttttgtgc gcactggaca agggagtttt gaagcacgaa ttgtttgcag caatttatgc 25680 agcaaaaaag gcaatttcga atgcatcctt agacgggaca ttttgtgctt cgtttggaga 25740 taaagagatg aaattagaaa gtgtaagcac ccacttaggg cctgccgttg tggtaacgcg 25800 tggggcaatt acagacttcc ctccaaagaa cgaatttatg gatcggctta catgcaagcg 25860 aacctttttg cgtaaagatg gggactttct cctgggatct gcgttcttaa tgtgtaagcg 25920 acaaaataga acgtcgccgg ttttacgcag gtggaaaagg gcctggcttc gagataggcg 25980 aaggaaacat ttaatgcgca gggcaagggt ttcggtaaca gctgagctgg gttgtcggat 26040 tttatcgcat ccaagcagaa tagcatcctt cgggctagaa gttacagaaa gagatctgaa 26100 tttacagcgg aggctttcgg cacatagacc gagggcccgg ggggtggtat atgaagattt 26160 tgattagtta cctgaagaga cacgccccaa aatcccaccc acgctgatgt atgccttggg 26220 cataaaatac tctgcgatct tcgcagtggt caggcatact ttatacgctc caacttcagt 26280 tgtcatggaa cagcggcgag acgaaaaaga agcggaggaa cagaaagtat ctgcaatagc 26340 cagtgccttt ctcaatgtgg gacaattttt ttctcgtggg caaacgaaca agtctcgacc 26400 gtgggtcaca tcatctgaaa caataaaagt ttctatatat gcatggactc ggtgcagaga 26460 ctctctacta ttttcagatt acttgtttcg ccgcggcacc atggatagtg cccggcagca 26520 gttgcaggtt ggagtgccta agaagggcgg ggtgtacaga cagctatcac gtgatgatgg 26580 aacggtgttc gaggtcagtt tggatcctgc agtgtgcttc gagttctcag tgacgttaat 26640 tttaccggga catgatcttt tctggccggt agtgccgccg ctgcaatttc tcgagctgat 26700 aagtcagcgc gcggttattc tggcagacca gtttatttcg tcctctatca tgaagcgagt 26760 gagcttatct ccaatcatgc tatttccgaa gaatacattc atgcccgggt actggtcccc 26820 ggatccccag cctggtcggt accgaccaaa atttcagcct actcgatcag aacaacattt 26880 catgaccgtc ggcaagctgg tgccaccgtt tcaaattgac ttgcatggga aaaagaataa 26940 tttcatggct ggaattgccg tgggttttca cggcccgccg accttgacgg gcactattcg 27000 cgccctgact gaacaagcaa ttcacaacgc tgtggccgag gtggttcgaa cgcttgaacc 27060 gatgactgtg gttccgatca ctctgaaaaa tggaactgga gctctgatgg gattgacttc 27120 agacaacaag ggtcttcgga tattgataaa accggcacta ggagaattgg ccaggtctcc 27180 acgaagacgg cgttccgaat cgcgcggaag agagtctgtt ttattataaa ttgaataaac 27240 gcagactttt tattactgtc aataatttat ttattggtct ttattacacg gctccttcgg 27300 gtaacattat acacgactcg attgcctctc tggcaaccac taccgcgttc tgcatagtag 27360 ggatacacag ttcttgttgt tgcggcaaaa cgaccaaaat gcctggcaaa aaactgcaaa 27420 acctgtacgg ggaatctatt acttgcgccc cggccgttgt aaaatctggc gttggtccac 27480 tttctgacaa catggcggcg gcgtaaaaac tcacgtttcc aagaatcgaa taggacctgt 27540 cccatctcaa gtttgcgtag gttgctgcgg agagcgcatc ggggagagac agggattccg 27600 cacgcgtgaa ggttttaggc cataatctca gatatgggac gaagtattgc tctccgagaa 27660 actcttctgg gaaggcgatt ggggcgtcaa atattccaat gcgtactctt cgcgttagac 27720 atgttccgga aaaatatatc ggaatgtcaa gagatattgg ggaagatgct cccttgcagc 27780 gcttttcgta taaaaagcgc gggcccaata tttccactaa tattgcctgt agtgctggtg 27840 caaataaagg gtcgcctgtg tgatcaaaag ccgattgaat cccctgtatc tcatcactgg 27900 tcttgccaaa gagttccggt agatgctcag gcagtatgct gatgtgatga taagatctgt 27960 tagaaaatat ccaacaaggg ccctgagcac taggagtagg cctttgctgt cgtatagagt 28020 ttccgtgtcg ttccttgtct accatactgt cgagaagctg gttcgttatt tcagcatttt 28080 cttgtggttc atcatctttt ttacgccgga gtgtttggcg tatccagcca ctccgaccgg 28140 agtgggagtt cttaactgaa ggtaatgatg gcgcgggttt cagcggaggg gaaatcggcc 28200 cagatatttc cagtcggtgt agctgaggtt ccgatcgaga gaagcgcttg cggcgtccaa 28260 acggcatgaa tttgctcagc cagcccatgg tgtctcgcct agagagttct gagtttcaga 28320 gcaggctctc gcctagagag ttctgagatt cagagcagac cctcgaacgc gttcgagggc 28380 ttttaggtgc ttgttgcatg gggcgtgtac tgggcgtgga tataagacat gtgcctcgac 28440 gcccgccacg cacgatttcc gcagacatga gttccatggc ctgctctcgt tttcagaaac 28500 caaaagcgaa gaatgatagt tcgcccgaaa aatgtgaacg cactgccaag caaattgtcg 28560 cagcaagtga ttattgcaat gattcggaaa aattagagga agagatggtc ttcgtcggag 28620 ctggaaagat ttcatattct tcgtggatgt acgaggcaat tttttcctgt gattgtattc 28680 ccgacggatc agcgtttgca gttgctaagc atgcagtgat cctaaatcgc gtaaacggag 28740 gcttgccatc ttgtcttggg agtgcacatg ggttgaccat ttaccctgcc aggacaagcc 28800 agcgtggaag gttcagccgt ttagcataca gaaatgatat gtccccagct ccacaatcag 28860 aaaatactgt cgatgtggat ggagagcttg gagcgtgcgc catcggcgtg ttggagatgg 28920 gcgaagaagt gtgggcacat gaagaaatgt tttttttacc ggtggttcct aagttagatc 28980 gcatgtggcc gtgtgttccc aatcctgctc tgttttgggg cctggcgcgc gcgcttaaca 29040 atcttccccc caagatactc gtttcaggaa aacttgccaa agggttcatt tgccctctat 29100 actatcttag cgtaccaact tttggagaag agagcaaaga aactttcctt cgcacgagac 29160 agaagcagcg aagtctatat gaccctttgt ttgaccctgc ttcattactt gttcagccac 29220 aattttttgg atgtgatggt attaaggatt ctaataactt tcaagctggg cttggcatag 29280 ttttccagcc tcaggatgga tggacggcaa aaacaaagct gctcgagttg gacagagttc 29340 ggtcggaact tgtcacacta tttgcacgcc aggagcagtc aaggcctatt accgtgataa 29400 ttactagggg ggcagtcaga cgccggcttg tgttttctac tgttggaggg tttaggtttt 29460 catcctcgtt cgaaccctct gggacacccc ttaaaaccca ctcggtgact ttacatattt 29520 aatggaacac acatacgaaa taaaagtttg tcagaaatgt atttgcgttt attgatgttt 29580 atgtttcggg taattatcca aacagatcag gcagcgtcgc aattcccatg ttcttccatg 29640 cttcggacac tgctgtgcaa gcagccgtct taaaatcgcc tatctcatcg ggggtccaat 29700 gagagtgcaa taaaatgccg agtctaggtg gatcgtacgc gtggcaaatt gctgcgcaca 29760 gaaacttgcc gcacatggga gtttcttcta aaagagcgcg ccagaaggta aagcctcgcc 29820 cagtaagcca gctagtagct cttgatgccc atgtatctac cgctagatat gagcgttcgt 29880 ccgatgccaa tacccccgaa actgggaaaa acgcgcaaag aatgtgagtt cctttcggaa 29940 tcgaggctgt ctgctgtgcg cgcggtggat gtatttggct gtcgccaatc gcaacacaaa 30000 acgggatacg gaaagcccat tcttcgcggc aagtaattat cggcgaagct atctgtgatc 30060 gatacgcgcg taacccagta aatatcgccg cttgtagtag tccgacgggc gagtgatgcg 30120 ggctgtctcc gtgctttaaa tcaaggattt ctccgcttag agtaagtgat ggaggacttt 30180 gaaagaacaa ggccccgctg aatgcgcgta cagcagcaac aaccggagaa agttccaaat 30240 ccgagataag tcctaacatt agaaatccga ctccatcttt ccacttgtct gcagacaaca 30300 gtttaaaagg caaatacttg gctccaaaag tcatcgggtt ttttgaatgc acgctatcag 30360 ctacggcttg ccatctttgg aaatttttta aggaagctct tttcatggca agaaggagct 30420 gctcgacgcc aatctctaaa ttagaattag ttgtgtaggg agttctagtc atgataattg 30480 cagtagaagg aattccagtg tcgttggaaa gggattcttg cggatcctca aataatggtg 30540 ctgctacgaa tcggatttga gagttatcgg gctgttttga gtcatggtct tgaaacacat 30600 gaatagtcaa atccttgttg caatccagaa aaaacgatgc tgtgccgtgc agtacagcta 30660 ggccatattc taccttttct gtccatagtt ttccacgatg tgttcctaat tccatgtgag 30720 acgagtctac aaagtttgcg aggcagtgag ttactgcaaa acgacattcg cgattgctgg 30780 tagacagtgc tttggaagcc tgagactgct tctttgacgg agccatagcc agttattcgt 30840 gctgccgcaa gtgcagttga aaagggtttg taaggaacaa ggattaaagt tcgctctcct 30900 cgtcagacgg tagccgtaca cgtctaaatt gcgttgccga gctgaggcag aatttatata 30960 tagccctgat ggcactccat agagcaacca atccaacaag tgcccctacc acaataccga 31020 taatgtatgc cttgtcaaaa actattatgc ttctgtcaag tcctaaaatt cggacagcag 31080 ttccgtgtgg tcctagaagc gcgtagttat agaactcggg gttcatagac ttaaaaaatg 31140 caatagatga gttggcaccg gctaacagtt ctgattgaac atatgcactg tctataaaga 31200 aagcatcctg gaacccccgt agaccgtatt gaactatcag gtggttgcaa tatatgcaag 31260 ttttcgctcg tccattcaaa tgaccatcct ccatttttgc tgttcgcgcg atttgcggta 31320 gggagttgca acttgaattc acaaacgtta caaacaaagg ggcagctgtt gaggtatccg 31380 gaagtctgta ggtcattcca gtgctcggcg ggctacttgt catcacccaa ctagaatgcg 31440 cggtaacagg gaggaaaaat acgatgtggt gttccaggtc ccagtttaaa catttcttta 31500 cctctggaaa aaacgcagtt gccaggatct gaggggtcaa cagagcttgt ggcggtatcg 31560 gtgcactata tgatggcaat tcaccttcag atgataaata tattttggtg taaaaaaatc 31620 gaaatggagc agatgctgtc agaattattt tccatggtgc acttctggaa atatcaaacc 31680 ttgtcgcaat tgcacaagga gaaaaccact cttcaatttt cgatgcctgt cctttcttga 31740 agctcccgtc tggttgggag tgaatctcgt tgatatcggc tagccggtcg acagagcata 31800 aaattgtcat gcgcctgagg aagttccttc catgttgtat agaaagttga ggagcccgca 31860 aaataatgta cgtagaaact gccaataact ttctgtacgc gggggtcatt accttttgtg 31920 taatgatttc tctgtaactg ttatctatta tttcaagagc cagttggctg ggggtcactc 31980 catcgatgct cgccaggaat gcattttggg gatcttgttc tgcagtgata agcaccgcat 32040 tcatgatagt aagaagcagg ttatgatttt ttatcatggg ttcccatggc ctgtcgtgca 32100 taattttaag aatactggat gggatagaag taagagcacc accgacattc tgaataaagc 32160 gaatattcgt tgtatagttt actgaattcg cccccccaaa acacactgcg acttggtctg 32220 cccatgtttg cgtttctgca ataaactcga cgatctccga atcagttacg tatgcatcga 32280 tcgtaaactt tagaaatcga aaccacgcgg ccataaaccg tgctgcgaat cttacaaaaa 32340 aagactcgtc tatggtattc gggcaacctg cgattgcgac cttctgcaaa gttaaaaagt 32400 gtcccgcgga tatttgttcg tcgaagctgg ccagctctaa gaaatcttga gcagcggtcg 32460 ttactgctgt aaacaaattt ggccgataat ttggtccagc tgcgacgttg atgcgcacag 32520 ttaacccctg atcttcagcc ttcagcatat agggccatga cttcagggac gtttctttaa 32580 ccttcgcgct ggttggtgta attatcatct ctatttgagg agaatgctgg gtcgcgatta 32640 taagggtcgc cacattcagt ccgatgttaa tcttaagatc tatgtcacta gtaactgcga 32700 ggctaatata tcgtgtaaac acaaatggaa aaacagtttg taaaggatca ctgtaaatta 32760 cacgaatcgg agcgatgatg ctctcgcccc tatgaactga gttatttggt ggaaagttga 32820 cgagtttcgc agatgtaagt gcattcccct tgtatcctac caaaagtcga tgctcaagct 32880 ttggatcgtt gctgaatttt cgtggttgga tggtagcctc gctagcagaa ccccatctcg 32940 agtaagtata ggctacgtac agttgtccaa gcaaatctag agcgatcgat aaattcctgt 33000 tagcgcttcc aggaggccca aagattaagt ttcgatcgac aaggcatagt tgtgtgatgt 33060 ggccgttttc gactgctgtc gctatcgcaa tgaattcttt cggaggggcc aaattttcac 33120 tggtgggggg cacgaagaca atttttgcct ttgccttgtc atccccttta gctctaagta 33180 atatcgccag aatgaggaaa aatatttctc tcgcgtgtcc catcggcgcg ggttgctggt 33240 gaagccacgc tctctcgagt aagaatgagt acaaagcaag gaaatgagta aaggacatac 33300 tcttattgtg aaggattatg gatgcggaac attacgaacc catatcagca ttgtagcgct 33360 ctactgcgtc aattaagctc gcgatcgccg ctcgtttggt tgtaagagaa cttgccgtct 33420 cggcaaactc taaacatttc agtgcacatg cctccggggt gaggccatgt gctggtaagt 33480 aaaaaatgca caagtttttc aataccgtcg cgagtttttg aaccacaaat gaaagtacag 33540 tttttaatct ttccccgtga acattttgct gatcaaaagc taatattgca aatagcgtct 33600 ggtcgattga aggattgatt tctggaacag tagcagtttc taagcactct ctcttgaatt 33660 ttaagagcgt ggcacttgtt aaggcttctt gctccttcaa caatgctgga taagatgtac 33720 gttggaggta ggtggtagta ttcatgaggc agatgtacga gttacgtaat gcacacaaat 33780 acgtccagtc gaccgtttcc cctgggcgcc ccctttgtat tatacgccgt gcctgttcgc 33840 aaatatccaa atccattaaa acaatgttgg agtgtgttgg aatgtcagga attcctgaca 33900 ataaagttat taaatctcca aattcgagcg ctccgcttag atattgtgca acagggaaac 33960 acaaacatgc cgcgagtggg tgcctatcta cgaggaataa gacatcatct ggtccggatg 34020 cagctgcgct gtagcagcgt tcagatccca aataattata aatgacgtgg ttcattattc 34080 ttagtggggc agcaatagtc atctgaactt ccgctacgcg acgagacgcc tcccgacatt 34140 caagttttcc ggaagccttt agggtttgta tttcattaat ttctttgatc atatccgctc 34200 cgccaaacca ttggcgccat gcttgcatag gttccgctaa gtatagacgg caacctctcc 34260 aatttggcat ttgcatcaac gtctttgcag tgactgtttt accgactccg aatggcccgt 34320 cgacgtaaag aagtacaacg cggcgaaagt cggagtcatc gttctcgaac tcggagcaaa 34380 actgcacacc accggaagtt ttcacggcgc cagctacggc catctctgcg ggctagacta 34440 aatgccggaa tccgttgcca taatcgcttt taccgagctc tcgtcagatc actggaggaa 34500 gtctttgaag ggggtggaga cggaaggctg gcctatacga taattcccca atgcaaacct 34560 gccgggggca aaattgtagt catgtttgaa gtgaacctag ggttgcggaa acctgattgc 34620 atttgtttgc tggagacaca acatgaaatg aaatgtattg tgattgaact gaaaacatgt 34680 cgtttttcca aatctttgat gactgaaagt aaattaagac aaggatatac tggcactctc 34740 caacttcgcg attctgcacg attgttggag aatctggctg ttcctggcac tgagaaagta 34800 aagattcttt ctctactggt atttgttgct caacggggga tgaacatctt ggcggtaaaa 34860 acggttgggg aaacggttat aaatgtatcg tctgagcttt tctttgtcac tctagctacc 34920 agaagccagt atttaaagac tttctgcgcg aaattagagc cacgcgtgtc gcatgcgcgc 34980 agtaagtatc aacaagaaag tgcaaagaat gcggatctag cgtctcccgc cccttcagcc 35040 ttacaaaccg tagctgcatt gttttcgtcg cgcgtgggaa aagagtccgc aaccaaaccc 35100 gcgagctatt ccacttctac ggaggagtcc aaaaacttgt ccgaaccatg tttcgaccca 35160 gattcgaacc tatgaattta ccaaaggaca gcaacaagcc gtctaccttg atggttttag 35220 ccgatcgttt aaactttatc tcctgcgcgg aaggctcgag taaatatgca tctaagcttt 35280 tcgaaggaac tctaatagac gcagaaatca tgaccaatcg tgcaaggatt gaagatctgg 35340 aaaggcggaa cagggctgcc aaggcagctt tagagcaact ggaaaatatg agcgctactg 35400 ttcccgtaca tgtctcatcg gcattgcaaa ctattgaata tcccctagag actgtaattg 35460 atgtcttgga tgatttagcc cagcgggccg tgcaggagaa ggacattgtt gggtcttata 35520 aaacactaga catccgtgcg cctggcgagg atgtccctgc gaacgtaatt tggatagtta 35580 agaatggaga accattaact tttaatacag attttcaagt agattttctg acaacttcgt 35640 ttgctattgc tggcaatggc cggctgggat tcgggtcttg gtttcgcgcg ctacagactc 35700 agctcctaga taacaataaa gctatcgcta gggttttgaa tgtaatggga gacacgcgca 35760 tctcggggcg gtttatgaaa acggctattc gagcgctgcg atcggcgatg gaaatttatg 35820 ctgggactcg acaatatagc ggattcgagg ctactgtttt atgcttactg cactactcgc 35880 ggtctagaca atctgcttca aacattagac atggtcttga tgtttctata tttgaagatg 35940 cattaagaca tgttccaacg tatttaaatt atatgctgga agatattcgg gccgagtggg 36000 gctcagttac attttcattt gaccggtcaa aactccccgt aaactttttt tccccaattg 36060 acggcagaaa atattcgaat ggagtgttcg atcctcacat agtgtatcaa ttgctaaagc 36120 gtactgggac cctttccacc acagtacgag atataacgaa agaaactctg cttccaatag 36180 atccagattt tgttcgtttt gatgacccca ttgctgctct ctccatttca tttttccctt 36240 cgagacgaac gccgttaatt cttcatgaag atgatccgct tgtgcgaacg gttatagact 36300 cgatatctct gctcctagtc ttgcaaaagc taatgtttaa tagtaatgtc tatacgagca 36360 cacatctcaa tcgatttcag ccatctgcgt tctttgaatt gccacttgga acccaatcgg 36420 aacaggaggc agctaaatgg cccgtcgccc ctgggtcaag acctcaagcc accgcaagca 36480 catttgatga caatggacaa gatatggcca gtcgcgacaa caacttgttc tttttattcg 36540 agaaatatgt tgtacctatg tatagatatg acaacagatg tgaagttact ggtttctttc 36600 ctggtttagc tgcactctgc ataacggggc gcgttaaagg aataccgaca gcggtacggt 36660 tgggggagta ctattcctcc ctctgtaatc taattgagct tgatctcaga aaaacgtcac 36720 atgtgggtag cggggcagct gctgttttgg cggtacacga ttcattgaca ggtgacgttg 36780 aagagggagt gtccaggtta cttgaggtat ttgatgcaaa aaagcatttg aaaggaatat 36840 tgaggacatt caacgtggag tctgattctg acctgatcta ttttatgtgt cttggatgct 36900 tgccacatca cgtgacatat ggataatgct tagtattttc gcgatcgcgt ctctgtttag 36960 acaataaaag ggttatatct ttctgatcag tccgtctgtt ttgtcagtgt gttgatactt 37020 tgcgggtcga gtcggtctcg ctatgtcgga gaacgtcgac atcaaatata tcttcgttgc 37080 cggctatttg gtagtatatg accaccaaga aagtgccggg cgagaatatg agcttactcg 37140 cgagcaaagc aaatcggctt taccagtttt gcctggaaca attccgataa acattgacca 37200 cgagtcatcc tgcgtggtag gtacagtgct gacgatctta gacctgccga gaggactgtt 37260 ttgtttgggt gtcgtgtcaa ctgctcttgc acctattttt ttaagctacg tgcaagatga 37320 tgctcttttt gcgaatgccg aagaggggat ggttttgacg gagacagaga aatttctcta 37380 tcttctcagc aacattctac cttctctatc gctctcttca aggcggcttg aaaagaacga 37440 agtgcccgga aaagattttt ttgcacacgt ggcgctctgt gagttgggta gacgtgaagg 37500 cacggtagca atttacgggg ccaccgcttc ggaagctatt ggagcatttg atgatttgag 37560 cgcaccaatt aaagaacagc tgtatgaaat agctacacgt gagaaatgtg cagaagtccc 37620 tagagagttg tcgcgaccag aaattacgcg agtcctgatg aagaaattta ttcacggggc 37680 gtttttgatg gataggggta cctgtttgaa aacgcgacgc gagatggcag ctgtttacaa 37740 cccgaaatat ttacaagcga atgaggtaat aaccataggg attaaggaac actccgaaga 37800 gactcctgag aatgctatta aagaccgttc agtttctacg caaacggccc caagcttcga 37860 tataagcgag agtcagcaac cgtccgggca aacacacgtt ccagccatgg agtcggcgac 37920 atgctccggc cagttcttgc aaacaaaaaa cggagcttca ccgtccgcat ctcgtgaaga 37980 tatggtctat gtcccattcg agaagtatgc gagtcttctt gcggcatcag cccgcagaga 38040 taacgaccgg agacccgtgt cgccatcacg agagttttcc cgtaggtcgc gggactctac 38100 tcacgaatgt tcaccaggac gtgatatttg gccgcgtgga ttcgaacgac accctcgcct 38160 agaatctttt atgggtccgg ggatgaacca cacttacaga ccggctcttt acgaagaccc 38220 aaatttctgc gggcgtttcc catatattcc ttatcaaagc cccgcatcta cttaccccgt 38280 gcatccaaat tattatagtt cgaacttcgg ccagtttcct ggggctggaa cgtatcctat 38340 acagtatcca tcattacatg agcagactgt tgtttcacgc ttagatgcct tgatttcggc 38400 tcttgagaaa aataataaac gggatagcga atactcggag aataaccctc ggaagagatc 38460 cgctaggacc atttctgaga atgacccgta cttccctggg gaaatggttc cagcaaaaaa 38520 gataactacg gagcagcagc tatgtgaaaa aaaggaaccc gttggtagcg gaattaatga 38580 tattttacaa ggaattctga cccttcaaaa agaggttgcc ggtcttaaat cagcttccaa 38640 tgccgattcg tcttcagaga gaaaagagga actagaaaat agtaatcaag agtctgctcg 38700 ggagacagtc gatgcttcta tgccaaaacg actgaaagat gctcagacaa aattgaaaag 38760 aaagaaagaa gcagccgcat ttgcgcaaat gatggcagac tgagtcatgt gaatagtaat 38820 gtcattttat taaataaact gcatttaaac ttattcgtct tcgctttctt ctgcccacga 38880 agggtattcg agcagggggt agtcatcttc cttggttcgg ggttttctgc gaaataggtt 38940 tctcatattt ttagcaaaag cagaaaaccg cgctttctgt cttcgagctt tctgttcatc 39000 cttgtgtaga agctcaaggc ctttcagaac tctggtggca agtatcctgt cgtcctcatc 39060 actatcctcc tcaacctcct cctcatcctt gtagtaacgt ctagagggtc gtggaggagt 39120 tccggccggg ggaactgcgc ctgggaacag aacctgaact gggtttgatt tcaggttcat 39180 tacatatttg aacgccagca gtcctaaaat aatgctcacc accaccgcta tcccaattcc 39240 gagtgcggcg aacgggttag aaagaaatga ggcgatgcca gatactgtag aaattactgc 39300 tgccgcggct gtcatcacta cagttcccaa tgcctttcct acttctccaa gagtgttgcc 39360 aaaaaaatct gctattgctc taaagattgc atctccccta tctccacgta ttacagtgtc 39420 aatgtctctg aaccttttgt tataaatatt ttgatatctg accacatcat catagtttaa 39480 agtcccagta tctctgagtt cctcgcgagt gtatacttcg acgggcacaa agtccaaatc 39540 ttctagtata gtggcgttca agttgatgaa tgtgctcact tcttcgatct cggaagcatt 39600 tacttgtcta acaaatgtat agtcttcgta aagaaggtag ttttctccca acagaaagta 39660 ccgtctgtga ttgatcatgc atggttctat caaattccgc ccttgtaaaa tttcattatg 39720 ttctccgagt tggcctaata tgtcaagatt gtggttttct gttgagttcg cagaaaactg 39780 tgactcaggg gaggacgaat acctgaaaat aagtactggt ctggtatagc acatggttgg 39840 gtcccctggc acgcgcatgg aatcctgcat cctaatattt tcgattggaa tttctataca 39900 ttttgatacc gctacgatgt ctcccaatag cctggcgctt acaggttgtc cgaacaaaga 39960 tgtcatcagt gagttcgggt ttagtttctt catctcgtgc catacaatca gttggcggtt 40020 ctgaatctca caccacgctt ccaacaaatt tccgataagc tcgttaacat gggcttggat 40080 tttgtcgtat gcaaattgta acatggcaaa tgttgcagaa ctgtgggtag taattctatc 40140 accctgaggt ccagactgca gcgacgccgt gcggcgacct gcggcttggc gacgctctct 40200 ccctctcggg agatgatttt gtctttgtgc ctcttctagg tacatttcag ccaagccatg 40260 gctcatgagt ttctgaaatg cgatcagaaa tccgccacta ccgagatagt attcgatgtc 40320 cccagaacgg acatgagtcg aactatactt tctggcaaag atgccatcta tggcctccga 40380 ggctatggta ggaacgcatt cagccaaatg aagcctgctg atgttaaaag gttgttttcc 40440 ggacgagaac gtcatagtca tatctttaag tgaaaagtgg taactgtttt tgtacgaaac 40500 acgaactgct tccgggactt caatccattt actgagagta catacagatt ccttttcttc 40560 cattgcatcc cagcctatag tgaattgttc atctgttaga aagtttcttt ttttaggggg 40620 tcttatttgt ccggtttcca aatccctgac ttgataattt gcgatttcga gaaatctata 40680 gtctctgtag acactgtgac gccttggtcc ggtcgtgttt ttggtataaa aaggagaaat 40740 ttctactgta tcacctgtcg ccattccaaa gtaatcatac gggtatacag atctagcctg 40800 tagatattcc acaacacagt cgaccgatgt agacgttcgg tatcccaggg tttgatgtcg 40860 cttagtaaag ttagttgtat gaaacgcctt ggagacagtt gatcttaaca gtgatggaac 40920 caggggcaat tttttttctg cttcatcatt gtcgtaagct tcaaaaaaca tgaaattttt 40980 atgatacgtt gctttggatg agcattctcc cgatcgatca atcctgacaa tttcatgata 41040 gtctattgga accctggtca cgtactcatt tgttatttgg ggtcttgaga ataatgccca 41100 cgtagtaact gtggttatat gtttatagta tagagtcaca ttaaagacgt acgggacaat 41160 gttttgcttg aagactacgg caattccttc agtcatgtta gtcgaatcgg catgtcggtg 41220 acaatgtcgt ggctgggcaa gcctcgcaac actggcgcca gttggagatg agcacgcaaa 41280 aattctgttt ctaatctggg gttctttcgg tgcccccgac ccaatggctt cggagaaaga 41340 gatttttcca acatccatgc tggctgtatc acgagggtct attattccag caattccgtg 41400 tgaatcttga gatagggtag atgggatcag gattgccacg cacacgcaga tcagcatttt 41460 caagctagcc atgtcaatgt tcacggcgat gtaggattgc atacaggacc gcgtataaat 41520 ctttctctac tatgatagta gacgctggac ccagtttccc gcggtcatcg acgccccaca 41580 ctgcaactaa tggatgttcc tcttcaaatg ttaaatatag cccgttttcc aaaatcgggc 41640 cgtcgaggtc gaattcgaca caatctgctc gcagtaactt agtgttaccg ctgtggaaaa 41700 ttttctcgaa agccgttgta gcaaagagtg cctctctgat atatccgcac gcggctctct 41760 gaatagcagt tgaattagaa atgcccgcga agttatagaa tcggcgaaac tcacttgtca 41820 tccaatcaca tgatctgtga cgttttgtaa agttggccaa ctcttctttc aaatgaggaa 41880 gaagtcctac gttctctaca gaaaagtata tagacgtgtt tgggggttgg ggaaatctct 41940 ccttgtgatg tttgaaaagg gggccgctta aaatttcaaa aaaccgattg gtgaggcgcg 42000 gtaacatggt ttggtcgatt tggtatctgg tgatggaaga gcgtatgtat tgatgccaat 42060 cataagcacg cccatcattt tgatcgatgc gtagaatttt cgaatgtaga gactcttcag 42120 cgcaaacaat atccagaaat gcgcgtcttg ctagaaacgc attctttagc gttacgtaca 42180 ttaccggaag agtttctccg taaatattca cacgcattaa tttttctagc tcggctcgct 42240 gaattttaat gcatcgatcc aagtttgaaa atgatcgtgc agaaagcttt tcgacgtagt 42300 tcttttgtct gacatcaaga tctcgctctg ccttttttag aagaacttct atcgaatcct 42360 cgtccctttc aatagttcct ctgaggttag cagtcaggtc gcttgtacta gttccttctg 42420 tgacaggttg tgtctccttg tctgagccac gcagtttttc cactaattcc tccagtgcat 42480 ctgtatctac tttctctggg tttcttaatc tgcgaaacaa tgggagggat agatggtggt 42540 catagcaggc tttgatcaag gcagctattt cggtatccgg tgaagtggcc agtactcctg 42600 tgatcagcgt atccactaaa gaatgttgtg gggatattaa ctcagcttgc gcgaccctgt 42660 gaaaatgtgc atgcaccttt tcaaacagtg ttctttctag acggatgcat tcctgttcaa 42720 agtcttcagc tcttttgaac agttcgctca gatctttgtc taactgcttt aacacagatt 42780 gtgaagtagt agtttgtgac tctactccgc tgggggtcct tttacccgac gctagccagt 42840 attgtaattc acttagttga tagacgggcc ccggtggttc cgtaaacaca tcatatttgt 42900 ttaagatttt ggaagcttct gactctccag gggaacttga taaggtgcgt cctgcttcga 42960 cgtggttttc agcttcgatg cgagtctcgt ttgaaagcac attttttaat ttttcgggat 43020 ccacatccct taaaaatgga agatggcgtt taaggtcatc cgtagataca ttgaccggaa 43080 actgtcttgt caagtgatca caaattttgt atccaaggcg tcgataaatt gtttctccct 43140 gattagcggt tacactaagc tcttctaaac acacataaca cggctgacca tgatcgtaag 43200 tatccggtgc tgctacgaga cttccccccg agctgagaac caaaaactca tctattgtat 43260 ttagagcttc aattgcgttt ttacaagata caacgcagtg acagtagttt agttgcttca 43320 taaagttttc tacatcgttg atcagaacga gttcctttga aataattgaa ctcattccat 43380 ataattgtag ctggacctcc gcatgcaaag gacagatgaa tcctttcccg tacccaagcg 43440 tagcttcaaa aaaacatttt ctatccttta ggacagaata cttgtctatc tcattacaca 43500 aagctgctat ttcggagcac gctcttcgaa gccagagcca cacgcaatat gtctgaaggg 43560 ttaacctata atttacttgc atagagagct cattagaaag gagcgaatga atgtacaatg 43620 ccattagcgc gttgtgtttg attctcgacc gcagtcgctt ctgcaacaat atctctggat 43680 cgcagcgctt caaaatatct atttgaaata acagcgtctg tagctgacct gccagagcca 43740 taaggcgtaa ctgtgtttct tcagccatat tccccagtaa gaatgaaaca aaatacgtac 43800 aaggactttc ttatatttat ttgtttattc tgagcatgcg cagttactgt taacagaaca 43860 gaatatcagc cgatagcgaa ggtttttttg cacttggcgc gccaagttca atatcttcgc 43920 tgatgtcgcc agtgtttgta tcttcatcct cgtctgccca gaccaacatc tctcctgcat 43980 tttccgggca tgtatctttc ccctctagct cactgagcat actttgtgcg gtagccacgg 44040 accacccatt ctgacttcca gaaatgtcct catggagctc tactaatata tctaccagat 44100 acttgtcgtc agtaattgcc atccatgttt cggcagtaat gtctttcatt ccttctccca 44160 gaactctcag aacggctgtg tagatggaag tgggactacc tcctgcatca attaggcttc 44220 tcacttgaga ggcaatggtg ttttcttgaa accctgatgc cacttgccca gatgacagaa 44280 tagttcctac ccttttacaa gcaagtgcaa actttctgac gggatcattc gtcagcgcgg 44340 aattaaccga ttgggaccct gaattgccta taaggctacc ccaattgccg gactgaaaga 44400 cggtggtcga gttttgttgt cctacatatt tgctgatcat aatccctaac attactatag 44460 gtttagaact caataccacg cggcacgagt ttgacgtact ggatccgctt atgcagtagt 44520 cagagacttc ttcgtgcctt tcctctgact ggtgtgcacc tgtgtctccg agttgtgcgc 44580 gcgcgaaact ctctttgccc tcacttgttg gctttatgga ggtcgtaatg atcatcgatg 44640 gagtacttat ataatattgt gctctgccgg ccatctctcc gtggtcgcag aactccaaca 44700 ccttgttggc gagcataaaa tttgctagtt caagcagggt agttggggag cacttaataa 44760 agtttccctc cccatagacc tttgaagttt ttcttataaa ttccaaatag gtaatgtgct 44820 ctggagaaag gcgtcgtttg ggcatattcc cagtcaagat caaattccag aatcgaaatg 44880 cgttcatgtc tttgccgaaa agatttgcat ggtcacgctt gagtataaat cccaatggtc 44940 cacccaaaat attgattgtt ttggtgcccg gtttcaaaaa ggcatcagcc attccttgca 45000 atctgcctct gttgctaccc gactcgctgg atccgttgaa cacgacgcgg ttcttcacct 45060 taaactcttt cagtttcagg acttgtcccc tagaaagaga atactcatat tgtgcgattg 45120 cctgttctgt gtttgggcgc attgtatccg gagcgttaac acacggaact gatattgaaa 45180 atggctcata ttttccagaa aggaatcctt tgtccagcat cccgttaaag gctgatctta 45240 gggccggcat ggcagaagaa cggaacattt ttgactctgg ttgccgcgta tcaaatgttc 45300 catggatttg actgagaatc aaatcttgga aaagtattga gcgagtctgg gcgcacaata 45360 agctaagtac tggacagtac gcagaagaat acgggttcag ggtgattcca aatgtatgta 45420 cgattgagga taagtgctct ttgtaatgat atgctctcac tcctgagagg gcagaaatga 45480 acttagagca ttctgatcca acgaagttct gaattttttc aaatacagtt tttaattctg 45540 ctaggcttga aatattatgc gtgtcttcgc ccgtgtcttt gtttatcaac ccttctgata 45600 ctagatattg aaagactcgc cagcctatgc ccctgtatgt gtcattcata actgctttgg 45660 ctggttcacc gtcacctgcc ctctttaact gggaatacgg ggcaaaattc cccaaaatgt 45720 cgcagtccgt gtagtctcca tcaactgctc ctatcactgc gatagggctt cttctcatgg 45780 ttcgtggaat aggaaaacgg gttctcagtc gctgcatagt gtaacggatg caatgattcc 45840 tagactcgtc attgcaccac cggcattctg gtacggctcc agtacaaggc gcttttccac 45900 tgttagaaat cgaaatcaga ttcatgtttg gccgagtgct gagttgcttg gaacattttt 45960 ccaaataaaa tatgatacgg gacaggagtt cggggctaaa accacaggca tatgcgaggt 46020 gctcaggatc atattcgaat gtgttctgag gtgtgagtgg agatggacat gtgccttccc 46080 aaactctctt ccctgagtag tccacctggg ggcatcccaa taaatgcaat ccacatgtca 46140 gataaaaacg ggttagtccg ctcgaggcgc gctcgccggg ctccggcgca cccccatcga 46200 ctacctcact tgcataaagg ggggagttat ttgaaaaaat tgctgctcct acaatgccgg 46260 ccaattctgc tgagaaccga tcgagagctt gaacgcgctc catttgagtt ttgcaatcgc 46320 agaacaacgg ccactcttca tacggcagac cgcagccatt atcaaaggga tatggagcgc 46380 aggagacaga gagtctagtt gccagcgcaa gttcagcagc caagctacag gcggcgcgcc 46440 gttctacttc tacattttgt ttagggggtc ctgtttgttg tatgttctga gccagctcgg 46500 taaaggtctt gtccgaggtt aatacacagc cttcgaagct tccatcgaac gcgagcattg 46560 ccgctccgcg cgccacggct tctaggtctc tggttctcag actttgtccc tgtgttccga 46620 gtgttgtccc atgaatgagt ctgttcaaag ctttgttgaa taatggggta gggtaaatgc 46680 agccttcacc gatgttacgg ctgtttgaat caaatgggtt acggcaaagc cgcagcgcga 46740 tgtctggcat gtacatttgc acagggtaga ttggtatgcg cgtaacaagc ttagaattga 46800 tgtaaagcgt ctcgactgat ccatagtgaa tgtatgtgtt gcatacatac accgcctcac 46860 aaaacggttc ggcaactacg agatagagca tcgttttgtc agggtccata ttcagggatt 46920 tgcagatctc ttctcctgta gtttcgatgg catttggaac cggtccattt gggggtagtg 46980 aactgaaccc gaacctttcc cttgcgtcct cgcatatttt tgtgaggttt ggagtgaatg 47040 atgtaggcgg gatgcactct cctccatgaa agatatatac cgttgttgaa aaatggcagg 47100 gagataaaat agccgtacaa ttacctccaa cgactcctga tgacttagtt ccgatgactg 47160 ctgcgacgtt tggcttgaaa tcagactcta cagtaagccc ccgtatgaga ggagcgatgg 47220 cgcaggaggg ctggtcttga cttttggcgc acagtatctt ccattccttt ccatcaatct 47280 cttcgcgggg tcttgcatat acgtagccaa ttggcccaat acaccatggt ccgccatccg 47340 actttccgcc cttagttgtg ccagatgaac tcttttccat ttgcgcgagt tatctcagac 47400 agtatgatct cagatcagag ttccgcgtag tagagtagtc tccgtcactg agcacggact 47460 taagtaccgc ggaaaggaca cacctatgta tactttagag agttcataaa tatcgatgat 47520 tgcagtagct gggcaccgag tttgtcactc tgcactatgg acactttttc ctccgccggt 47580 actggagctg ctcgtgtagc cccgataatt ggcctcgggc cgcactctgg cgcgtcttat 47640 tatacttctg tgagagaatt cccgtatgta tgtccaacgt gcattaatgg gggcggaagg 47700 ataggaacgc agattggaag ggctacaagc aaaccaacct tttaccacaa cgagcgacaa 47760 ttagacatct tgacaagcac acatggagcg tggcccgtca ggatgaaata ttggaatgct 47820 ggtcctagaa tgactcacca caacaaggga gatgtaaagt tttatgaatt tcacgtttat 47880 gacctttttg aaaacactga gatcgctcag tcatgtgtac gatggatgca ttccagattt 47940 cttgatacac tgaaaccgac cggtactgta ataaccttag ttggaaattc tgcatgcgga 48000 aagcgcgtcg ccgttcatgt gtatggatct ttgccatact tttttgttaa aaagcgagaa 48060 attgaccaag ccgcgaaagt cacgaactcg gaagagttgg cgcatgctct agcattagcg 48120 acgcgtaaga catctttaaa aaattcacct tttctagctg tttcagcgga aagtttttgc 48180 attgatgttg ttcggcgcag agacatttat tattttgaat ctgaggagga ggacttctac 48240 cgtgtaaaag tgtgtaatgg caaagtgatg aaatttatat gtgataattt tttcccgagc 48300 gtacctaaat atgaaagcaa tgttgacgct attaccaggt tcatcctcga caataatctg 48360 acttcttttg ggtggtatcg ttttagagct caaggtggcg cactccaaat tcgagaccca 48420 ggacaacatg ctacatcagc tgatgtcgaa attaactgca cagcaagtaa tttggaactc 48480 ggaaacaatg cctcgtggcc agactacaaa ttactgtgct ttgatataga atgtaaagcc 48540 ggaggggcaa atgagtttgc atttccttct gctgagaagg tagaagatct tgttatccag 48600 atttcggcag ttacatattc tttgttaact aaggaaaaag agcaggaaat cattttttcc 48660 ctagggacct gtgaactttc cgaagattgt agtgatggga taactgtatg cgaatgtggc 48720 tctgagttcg agcttcttct gtgctttatg acttttttca agcaatattc acccgaattt 48780 gtgagcggat acaatattct agggttcgat tgggcctatc tttctaacaa gctgagcaag 48840 gtgtatggta tgcgtctcga tggatatggg aaagcaaact cgtgggggac gttcaaactt 48900 caagatccgt ctgcgcgcgg acttggaaga ttcaaaaaag tcaaaatcaa tggcgtcgtc 48960 aacattgata tgtttaccat tagttatgaa aagctaaagt taccatctta taagttaaat 49020 gcagtagcag agtgcgttct tggagaacaa aaaattgatc tggcttacaa agatatccca 49080 gtcatgtttg ctgcaggccc taaagaaagg gggaaaatag gggagtattg tttgcaggat 49140 tctagactgt cagggagttt gtttttcaaa ttctcccctc atttagaaat gtccgctgtc 49200 gctaaattgg cctgtatacc cttgacaaga gcaataggcg atggacagca gctgcgcgtt 49260 tatacatgct tgctccaacg ctctacggcg tccgggtttg tgttgccgga caaaaagagt 49320 gcgttttcct tcggttctac tcttgcttca gacgcgtctg atgcacctgc tacaagaaat 49380 gtaggctacc agggagccaa ggtactagat ccagaaatag gattccatgt aactcctgtg 49440 gttgtattcg attttgccag tttgtatccg agtattattc agagtaacaa tctatgttac 49500 agtacgttaa cgcacgaccc cgccgcactg gcaggtctac agccagaaaa agatttcttc 49560 cagattgatg ttcagggtcg gaaattttat tttgtcaggg agcatattcg caaaagtttg 49620 ctgtcagact tgctaggtga ttggttatct atgaggaaag ccgtgcgcgc aaaaatcaag 49680 acagccgaga ctgaagaaga gcgaatctta ttagacaaac agcaagctgc cattaaagtt 49740 gtctgtaact ctgtatatgg gtttactggg gtgatgcatg gaatgcttcc ttgtttagaa 49800 gttgcttcaa cagttacagc tataggaagg gacatgcttt tgcgtacaaa ggcgcacatc 49860 gagaaggagt ggagaagtgg aaatcagttt gccgaaaaat ttttgcccgg gtccgaacgt 49920 attcagctaa accaatactc tgtccgggtc atttatggag atactgattc tgtatttgtg 49980 aagtttaccg gagttgacat tgaaacttta actcaagttg gtggctgcat ggccgatgag 50040 attacacaag cgctttttag agctccggta aaacttgagt gcgaaaagat tttcgtgcgc 50100 ctgttactca ttgctaagaa aaaatacatt ggggtgatgc atggaggtaa aatgttgatg 50160 aagggcgtag atctagtcag gaaaacaaac tgtaaatttg tcaataccac agcctcccga 50220 ttagtgaatc tacttttcga agacgacgaa atagcgatgg ctgcagatac agcaagagcc 50280 ggatttgagg attttgactg tcttccgagc ggacttacta agcttggccg gttgattgca 50340 gaggcaaggc tagctattac cggcaacgga ctaaacatta gggacttcat aatgaccgcg 50400 gaattaagtc gtgcggtgga taactatgcc agtttgaaat tgcctcatct cacggtttat 50460 caaaagaaag ctgctcggcg cgaagaatta cctcaaatta aagaaagaat cgaatatgtc 50520 atcatagaac cgggacaatc tgtcccgaat gatccagcaa ctgagtcttt tcctgaacta 50580 aaagaaactt ctttgatttc tagcctggca gaagatccag aatgggtcgt atcaaatggt 50640 ctaaaattga atgtagaata ctactttgat tcgcttatta gaacattaag tgtaacattt 50700 aacgcaattt tcggtgatgc aaaaacagca gaggatgttt taagaagctt tattccagag 50760 aaaatacagt tttctgagaa agttgcagag gctcttgcac gaaacaccgc gacatttgta 50820 tccatcaaga agtaatcgga gggctgtaag ttgcaaatgt tgaataaagt ttagtgtatt 50880 cgtgaatttt ttcgtctgtt actaggatat cgcagtatcg tcgatacact gactccgggt 50940 tcagcttaac gcgctgatgc tcagagtaac ccggtccatc ttctttggaa acgatcaata 51000 agaacgtacc agcgaatacg tccacgtgcc aagtgtatcc tgggcaatta aatattaatt 51060 gtttcagaag ctttgcccct agatgaagtg gcgtgctctg tttaaataca aaatacataa 51120 ggtatcccga tggaaacttc ttagatcttg gatcgttcac caagagaacg gtaaaatctt 51180 gagagagtcc gccctttact gtatagtatg cataaaacaa agtcgcctgg gccagtagat 51240 ttttgatagt gtcaagtagg aattcgtttt catatgctcc agatccaact accgattcac 51300 ctgaaaatac ccgcagggac gccactaact ctttgaattc gaccacagag ctcaggtgat 51360 ggagaaaggc caattccaac gcaggcaagt ctaacggtgg ggcatttgac catccatatg 51420 agcaaagtga gcagcatcca ccaggtccaa cggtgtagcc catctcggaa agagagatac 51480 agtcgccagg ggcaaaactt gcattcacat tgtaaggaag ggagatattt tcttggcgta 51540 tgacaggaat cgtcattgtt ctaagaaggg agatagtatc ttccggagat gaagccgtta 51600 gcttgaaaaa agcatcgaag aaagttctcc gtgtgtctag attagccctt gacctagacg 51660 atcgcctctt cgatctgagg tatgagatgt agcgatggcg ttcgatggcc cccgtaatac 51720 tttttcttcg gatgcgcaga gcagcggcgc gagaacggaa gtcagacata tcgagtcagt 51780 gcgtgttcta aagcaatgca gctgattccg tgcctcttta aataggtctc agcgccgcga 51840 atgaaagaat ttaaagcggt agggcgagga ggagaaagct ggtaagcttt aaatgtgaag 51900 gctagaatcc acagcccgcg gcaaacccgt tcttgaaata tgttagccgt ggcgatttcg 51960 gctttataaa gctgcagcag ttctgggtcc ttgggttggc cttcccacaa aacttttgga 52020 tttacgcgaa gcgtattaac tgcacacaat ggatcgcaaa aaaagtgttt gtaaattgcg 52080 tttgccccgg ccatcctcaa taaggttaac attcgccccc catcgtttaa cgcagtatag 52140 tcttcgaacg tttctaatgc tggttcaatc ccatcgaaca agctgctatt tacgttactg 52200 cagccgacta ctttactttt cagctttcga agagcatgcc agtgttcccg agtaagcatg 52260 agattgcaca acacgcattc ccctccagta tctcctcggc tagtcgggtg aggcaaaata 52320 gacgccaaaa ttgggccaat ggcaagtgat ggtttggtat tgtcgcaaat gtactgcttc 52380 gctgtcttgg ggagcctagt atttttgacc tgttggatta gcgttgcgtg aaagttctcc 52440 actacggtat ttcttgtccg aattataggg gcaacgaaat tttctccatt atcatttgta 52500 tcatcatact caggctcgtc gctgcagctg gcatcgagtt cccgatttgg cataccggct 52560 gttccagcaa ttaataatgc cgtcaggtcg gtaaatcccc atttacttgg ggttgtcagg 52620 gtttcgcttg gtcccccttc cacatatttt gactccgtgc taatatcttc taaagcagct 52680 ttttgcgcac aggttcgaaa agcgaaggag gcagtctctg tatttttcct ctttaacata 52740 cactgcgcgg agcaaaaaca ctcgagtggt ctggcatact cacgccattt taacaaagcc 52800 acggccattc cgctactttt ttggaagttg aaatctgcag acgcgccaga gaccggggca 52860 atttttgccc taagtgcttc ttgatatcta gtagatagta acgcatagcg tgctaccgac 52920 tgcactagga acgaataatt atttagatct attttagagt ccagtccccc ttccaccgct 52980 ttgaaacagc cgttaaaaaa gaagtgcttc tgaatatccc cgagggaaaa ttcccgacgg 53040 cttatagcgc caactaaaga ggtgctgtgg gaatgcaagt agtgtttgtc catgatgaag 53100 atgaactcaa aagcagttat gaaggtagat gtagcacaca gggggatgct ttgagatttg 53160 aagcacaata aagagtagtc caccatccat tcgggagtca cggggaattt tttttgatat 53220 ttggtaataa tcttgcagac ggcgcatgat ttatctaggg tgtataagtc agccatggtt 53280 tctacgaaag aatcaatgtc cggaattctg ttttgttctt cagcttgttc tgtactttct 53340 tcatgatata tttcaattag gtgagctcca tacaatagtt cgtccgacaa cttgtcatta 53400 aacgtcagaa tcgccgggtc gtagccagta tatagttttg agagcactcc agctttccat 53460 cccttggaaa gttcagtgcg agtttctgca gttgatcgtt tggatgtcat ggcatccaca 53520 gttccgaggc gtcttagtga attggtagat gaagaggagt tagcggaaag gccactctca 53580 gaactgttca gaaagtatat tggatctgca ggtagtccgg tatatgaaat atggttttat 53640 gacctatcgc ctccggaaat tgaagtagct ctgcctacta ccgatgctaa actaaactac 53700 cttgcgcaca cagccaatgt cgcggccgaa cttcggtacc gcaatttaga tgggaaaagg 53760 atgtgcgcac acgcagaact tattgctcgc cgtcgtgaac ggttcgcgca aattctaagt 53820 aagtttttgg atcttcacca aattttaggg gcgctagaac cttgttagtc tggtagtatt 53880 ataaataaga gggcgagtgt gtatggtatt aagacggatc cagaagacca tgaagaaagc 53940 aatgaaaccc caaggcgcca gaaatcaagg agacaaatac tgtcaattgg tgcgcgtcgt 54000 gaatgctgga ttaagccttg ccggaacgac agcgagtctg gtgtatacca gagataatgc 54060 acgtctcgca cccactggag atatttttac gcttcttgct aaacttgacg gtcccccaat 54120 tccagcggaa tatatcctag aggcaatgaa tagcttcctt aatattggag agtcgtggct 54180 gcgtattcaa aatacgggcc aggctgtcat tgttgccgga tgctctacca agaccgctaa 54240 ttgcaaagac caaatatggc ctgcttctag tcctaccata tctttagcgg ctgcaaaatc 54300 tctgtgggta agttcctcat cggtgaagga aatgaaaaga cttcaaaagt taaaaaacgc 54360 cccgctcgca acaatgatgt acattagttt ttacaggggg tcgagaactg atattaccat 54420 cagattcgca ttttaccgct cagactcgga acccaatttg attaaaatta ctcgcagagt 54480 gcaagaggct atagactccg cggagcaaga agattcatat aaaacggcgg cccttcttaa 54540 aaaaacgttg atggaaacta caagcgagat gcccacaagt cactcggttg ctgagtcgaa 54600 gccatcacgt tctattttcg agcgcgtcac cacatatttt cgaatacatc taaaatgttt 54660 aaacccgagg tccttctctt tacagccact gatgtgggtg cttatgggtg tggcatggcc 54720 tgcttttttg acactactga tcttctattt aatccgagta caggcgacga gctgaaatca 54780 taccacacct ggaggcagat atgagcaggc aatctaactc tcattccacg ccccaaccac 54840 aggacagagt caatgcggcc gcagaaatgt tgaaagcttt tttattgacc cctccgagag 54900 atcgagctcc ggactacatg caaaccttaa acggaattac cttggatcaa ctcacggaag 54960 tagctcgagc cttgaaaaat gaaatcccga gagaagatac agttcggcaa aatattctta 55020 gaaataatat cacactcgcg ctaatggctt taaaccgagc tccaatgctt cgagatcggt 55080 taaatataag gcccgtattt gctcgccttt caggccctca aggattgtgg acgtttggag 55140 tgagacaacg caccaggcca agaccgagac gctaagcaaa acgcaataaa tataccaatt 55200 taacccagta ttatttttat tttgtgtgtt tcatccgcta tgcgggcctg ctgatctaaa 55260 gcgtaatctc tcgcgtgttt tattccttta agcaccatgc ggcaggtgac tgacagcgat 55320 gcataaatat cactgcgcgc ggtgggtggc aagggactaa gaatttctct ttcacccgct 55380 ttagactctt ccgcatcgct tgcaaggtct tctgatgggg ctttgtcatt tattgaggtt 55440 ccggaagata tctcatttac agcatcatcc tcttccgaac tagaatcagg tggagtctga 55500 atggatttca gatagggtgt gatcgttcca tcccgcaatg cgttgtccaa ttttctcaaa 55560 taagtatcta aagcttgagt atcccttact aacctttctc cctcttcaat gcgccctttc 55620 ttatgttcat cggctctgcg agaagattcc tcgtgaagtt tgtgcgaccc tttgacatat 55680 gccggtgtaa aatcctcgtc agaactttct ccttccgggg gatcgacttc cttgtcccac 55740 gtgtaactgt atgttgggaa gtgagctata tcctcattat ctgagcaatg tgtctgtttg 55800 gcttccgcgg tgtcatgttt atctctgtgg cttgttatgc tttctggcgg gccctcgtgt 55860 tcgctagttt tacgtgttgt tgccaggtgg cttcgatctt ctggttccgg gtctgtggga 55920 tgctcaaggt tagtctcgtc tgtaataact gcgaaattat cagacgggtc agaagttatt 55980 gacggactct gaattttcca atcacaagtt tctgagagta cttgttcgaa ttccgataat 56040 tctgattctg ttccgctctg cactggacta gcaacagagt atagactggt atcataattt 56100 ggatcccaca gttcggtatc ggtgtctgtt tccggactcg attctgtgcc agattgagtt 56160 ggggattcac tatcaatagt gcgcaagttg tctgtaggtg tgctaatggg cgagctttca 56220 tgttgatctg tcttcgcaca taccgtgcta tgaattgggc gcgggcgcgt acattcacca 56280 ttctcaaaac tacttttttc ttcagaagca gtattgtgct ctttctcact ttcggatgaa 56340 tcgctaggaa gaggaatttt ggaagcatct ggatacctta caggagattt agaaatctcg 56400 gtagttatga catgttcatc agatgaggaa gatagcaagc gtgacggtgt tttacacgat 56460 tctgaagctt tgaaatagcg agatttgcta ctcctgcgtt tgctcgagtg ctttggatgt 56520 tgggatgagg ccttggtgtt gccaggctcc ggtttcttaa aggttatccg agggggaagt 56580 tccacgtgtt cttttagctt ttctccatat tccggtctac gggtacaaat gtcctctgga 56640 tcttcgaata ttgggacatc tccccctact acatcgctat aaaatatatc cccaggatcc 56700 ccgagattag acgagaacgt ccccgtgtct gaaaatttta ctgggaggtc ctcatatttg 56760 gggtctccat ggagccttaa aacgaatggc gatggagctg tttcgagaga aactaatatc 56820 tgtgttattt tgtttcccct gtcgatggca aaaagtaacg acggagcatg cttgaggggt 56880 ttgctggaca gtacggttga taactctgct atctgggagg ccagacaggc gttctctatg 56940 gggttggcat caccggcaat aatgtctccc aattgaattg ccgtcttggc agtagtagag 57000 gacagcgcac tttctaatgg atttgttttc cgtccatcga aaatagtaga aaacaaaacc 57060 aaaccgttat ttgagcttag ttcccctgct tcatatgcga tgacgacagg tgctccaaaa 57120 agaagtgaaa taattgcgat atcaaaagcg gttaagtccc atatggattt atggggctcc 57180 tcccgaaggg aatatatccc agcacgatct acggtcccga acaatttgtc atcaggggcc 57240 tcgaagactc ggctgagatc actgtttggg gaaaagtcat aatcgcagct tggcgatgag 57300 cgggaaacca tataatgaat catggtatcg atgggctctc catcaatatc gtcatggggt 57360 cccatggaaa cccatagtgc ctccaggata ttcctcggga tgcatttgag ggcaagaatc 57420 attagaaagg cacttgtctc atattcttct ccggaacaaa atttttcaag catgcatatc 57480 cctgacctga cagagggaaa tcttttccag gggtctaaaa atctcaaaat agaggagggc 57540 ggaggttggg aaagccagtc tttagggtct atcacaaaac atgccccagc tgaaggatcg 57600 aaatgctgcc taccttttga tagagggaaa gagagtgctt ttttattctg agtttttctt 57660 tggtaaggat caagagatgt tattcctacc ttctcgcgca ctgccctaga taaaacaaca 57720 tctagggtat ttactatgta ttcagtttgc tttaaataat taagcctgcc aaagtaaact 57780 aggtgtgcag gttcgcatgc agttaaaagg attaaaatat caatagcggt tattgagtaa 57840 atgcgaactg ctttgtcgaa ttgatttttc tgattgatct tatccaggtc tgtgtggggt 57900 ataaagttgc ccatctcatc tattattaca tcccgcgctg accctaaagt ttttgacaga 57960 gtcagataag tcagggcact gtaaattgta catgcggcga ccatcggagt atctgtttgt 58020 ttgttcgagc ttggccaggt tcgggtggaa cagaaaatgg tgtaagaatg gaagcccgct 58080 tctatatcgc tagtcctggc tctcatccat agagttgccg cgaccaatga gagggctgca 58140 ttttgtctga cggataattt ttttactaac tcgttgtctt ttggattctc aagttccaag 58200 gagagaggct cactttggtc cgaagatgtg cataacgcag ctgaccacaa ggcggcagct 58260 tttgcagtgg ccgttcgata acaaagagtg tattccaggg gcattccgtt atctgtgacc 58320 atgaccgagc ctattgttcc gaggtggtga aacgtaaccg tcataaccgc ttttttattc 58380 tgtctcatat agctggaagc cctggcgagt tcccggactc tggaagaaaa gggagtctcc 58440 gcagaagata gtctcgggat gatgtcgtct gaaaaagcta tacccaaggc cttgtaagca 58500 aggtaaagtt caagtcttag cagtattaac tttttaatat cttcatactt tgctcggtac 58560 cactttggaa cagactcaaa aattgcagtt aattctaaat ggagagattt caaagctttg 58620 aaatgcatct ctgtctttgc tttaaagatt acttcgtcga atgttcgcat ggcattagtc 58680 agtgtgatga tgttttcttc tgccttttgt aatatgggag tatattctga aatgtctttt 58740 tgatacttct ttatttccgg agttgatgta acttgagcct ctaccatttg caaccggctg 58800 gctaagcgtt ctcgtgattc ctttagattg tgaactgcat tgacgtatgc accccatgac 58860 tcttcgctgg tgtctttttc ttttccggag gtttccttaa aggaagtggc agctgataaa 58920 aaatacttat agtaagcttc gagatctttc agacccgcgt cagcctcttc atacagtcgt 58980 ttaagttcat ccaatcgctt tttaaaatct tctaatggtc cgcgttcatc gatagagttt 59040 actagttcac atgtatcgag aatgtgagcc gaagaaaaca tccattccaa tgatttgggg 59100 tccacggaag ttataccggt ggaattgctt ttctcttcca cttcgcgaaa gagattaagg 59160 aaaaggataa ttatatcttc aagtgattct gccctttcga tgcccggggc aacttccttg 59220 ggcacgcgac ccaatagtaa ccctttcagc ttttttaagc ccttctgcat acgcaagact 59280 tcctcttctc ttacactcca taattgctcc agcatgtttt taattttgcc gtctgtgttc 59340 tttttttgtt gttccgcctt gttaatttct gcggataaaa ataatttaac atctcgcaac 59400 gccctgtgag aagcatcttg ataggcggta tggtcaaaca cagtgacatc atcggagtgt 59460 agactgtctg gcagctcctt gagtgcgatg agggccgtgg gtatcacttc gccgcggtct 59520 aaccgctttt tggcattttc tggacttctc tctatctgtg cactctcttc agctaattga 59580 agctccttct ttaactcatc ttgcaacagg attgcttttt ctttaatagt ttgaatcttt 59640 gatgaaaatt cgatgaattg ttcatgcgct tgcaagtaaa agtcaacaaa ttctgataat 59700 tcaggaatgc gcatcaattg ctcggacagt cggaaaacta cgcccctggt atcaatttga 59760 gacccttcta cggtaacttc tgccgtttcc aaaatatcct ttgcaattgc acaaacggtc 59820 gtcaggcctt ctacctttgc tccaaataaa gtttcatagt atttactgac caacgggaat 59880 gaatgtaccc acgtagaagc ggctatagga gctacggcta ttttgtttcc ctgccctgct 59940 tctgcattac cagaatatgg gttgaaggag aaaaacgatc gaagaagttt tgtgccggtt 60000 gcgagccagt catttacaac gttttgagct agatgtttta gttctgtgtg ggctttatgt 60060 gtactattaa catgtggtcg gagatcatat atcgtttccc aatcgtctgc cgaaaactta 60120 gcactgctac gatcttggag gagtgcagcc ttcgttgctt ccagccactc gatttcctct 60180 atggcaagta tggcattatg cgcagcctcg gaaaggttgc tacatgcttt ttctagagat 60240 aataattccg gggaaaatct ttcctcattg gtaagatcta actgtgccac ctctttctta 60300 accctttcca ccagcactgt agccgagtct gctatttgtc gatcacgtaa ttctgggaca 60360 ttcagttttt ccgtggcgtt caaaatgtct ttagtcagtc tttcaataac atccgatagc 60420 tgttttctcc ttgcccgttg ataagcttca gactccagct cgtagagatt atcacggatg 60480 ctaaatagaa actgaggtat ttgcgaagcc cctctgttat tttgcacatc atgaataact 60540 gcctccacct cttgtctggc gcgagagaac ccatccgcat ctccatttgc tttcgccgtc 60600 tctatgacga acagaagccg ttctgcatga tcgagaaaga cttcaaacgc tctgttcagt 60660 gcatgtttgt tttttcctcc ggaaagaagc gttgctgtaa aacggatagc gtcgacaaga 60720 tcatgcaaat ctgtggtatt tagggatcca aatgcacgtc catactcttc cagcaagttt 60780 tcgaaatcgt cccgtacatg ctttccaata aaatcatcat ttctagcaag gtttataact 60840 tcctcttggg gaatgtttct tgtctggagc gcgcttttta tatttcttag tccttcgaat 60900 ttttttaacg ggcgcaatat ctgcgtcacg gtacgtttcg tttcttcgtg cgcagtttct 60960 tcctttctaa tctctttgga gaattgatct atcaaacgtg aagcgcggtc ttctagcgcg 61020 tcaaggcgac ggctttgttc cacggtagtt ctcgcggctt tggctacttt gattgattcc 61080 tgtgtgtgaa ggacatattg caggcgtact tgggggggcg ctgtaatagc ttccactccc 61140 tcgagctcgt tttctaattc agccagcata ttttcagtta gcccaaaact ctgagcaata 61200 gcgttgatgt catgaatagc ggagatccat tttgtaggtg atgggacaag tccctctgca 61260 tgagcttcga atagatgtag ggaccatctc ttgagttttt catcggtggt aaggtctttc 61320 ccatcgatta ccagatctct gaaaattctc aatggctttc ttgtgaacag tacttgtaag 61380 ttcttcgatg ggtttcctgc aagttgccta atcaactgaa accgcctttc aatctcctct 61440 atgtttttta gccaattgac agcattctct acaaatagag tagggatgct aaaccttccc 61500 aatactccac cgaccccaga tgataatgcc gatatgctat agtcaatggc gcccgcatat 61560 ttctttagga atttgaccgc agcatcctca attctgataa ttgcgtcgtc gagctttcga 61620 ttaatatcct gaacgtcgag tcctgtaaat ttcctcaaac cctgtataat tgcttgtggt 61680 atgtccggag tttgggttgc ttggatattg atcacatcta ctcctatgtt acaaatttca 61740 tcaatgactg tccacgtatt ggcgagaagt gatagtactg caattttggc atcagcgaag 61800 cgtgcttcac tttctatcac agatttcgca gcacgctcta ctacatcagt aattttgtgt 61860 ccgtgtgaat taacatcttc tattagaata ctcgttttat ttgaacattc cagcagttct 61920 tcggataact gttcgtacgc agttggaagt tgatcacgct cggcactgtc tgcgatttga 61980 ttcaatttag caattaatat ttctgtctgc gttaacaggg ataaactgac ctgctgcgtt 62040 tttcttaaaa gaacactgcc cccttcactg ttagagtggc atagctccag gagcaagtgt 62100 ttcttttcga taagatcctg ataacgcagt cttgtagtgg tcaatatatt gctgatattt 62160 ttctctccga tgcgagccaa tagcgttgcc aatgggtcta ttagaaggtc caccgtgctt 62220 tccaagtttt ttgtggagac cccgttctct ataataaaaa ataatatgcg attgcaggta 62280 attctcacct tttcccgtaa aatcccagat cgcaaaaatc tcgtcagtgc cggttcgaat 62340 gtctcctgtg gggccggtaa ccacttaaga ggatcttcca aggcattttt tattggtgtt 62400 atggatccta attcaattgt tgctgatggg tttgtgtctt ctgccgtaag taaattccaa 62460 gatagcttcc tcctggcgct atgcggctta gtattgcttt gagcttctgg gtctgaacgt 62520 acggagtgtt ttctttgttt tcgtggtgtg aggtttgtca gtttttctga gcttccgatt 62580 tgatcaggat tctttggctg tggcttctgt ctcttttttg atcttggtct taccggaacg 62640 ctccatggag caatagcctt tctacggtcc gcgagttcaa aaaggttctt ctgagaaaac 62700 tctgggttta gtccgagagc atagacatgc gccggaaatg gatgaattat ttgtgtgctt 62760 aacgtaacac tgcttaattc agcatctgat gcgccatatg atgccattac tgatgccgca 62820 atgatttcct ggagcgtttt ctccgatacc ttttcttcgt cccacccatc cgcattgaac 62880 cagtagagaa aattcatatc tattccaact ccagacatat tctttacata tgcccgaaca 62940 aattctggga ggtcatcaat tctccttagc ttgcatacat aagcacttga catttcccat 63000 ccatgtgaat caaaaatgta cacaggatcg tcctttcccc cagaacacac ggctgcaact 63060 cccctgtcac cgatgatcat tatgaatccc aatcctttcc taattttctt ggcaatgatt 63120 ttggtaatgc cgtgtatatt catggaagat gggaaacctt cgattgtgac ttccatgtca 63180 taacccacat tcccgtatgt tatagaaggt atcatgagca tgtcaggttc atcccatgat 63240 gatctccaga gtctgggaag ttcgtgacaa tcaatcattc gaaacgaaca tttttttgac 63300 ttgtcctcca ccttggcctt ccctgttctc gtaatctccg ccccctggtc taaaatcgca 63360 tccaaactgt ccgcagagag catcgaatcg atcccgtagc attcgcaccc ccgcaggaag 63420 gcggcggacg tctccataca catatagtat ctaacaggtt catattttcg agcaaattgg 63480 ctggtcgacg cggctacaat aaattctccg aatgccggtg gtaatcttgt cggaggatgg 63540 aaatcctgag ccatgttcgt gacctgctag aactgtacat cagtctgctt ctggggcctt 63600 ttatttgttt gggaagagtt tcgtaaatgt ctagccaacc gcacacaaga acgcgataaa 63660 tacacaccac tcaattactc attagtcttt ctttattcaa acatttttac atttgcactt 63720 tccaaaactc gatcggaaac tgtcagaaga gtctctgatg agattagttt gtctggaagt 63780 gtgtctacac acccattgtc tatcccttct tttgtcgagt gtcgaacata gagcggggct 63840 ttgttggttt tatcccacga agtaatgtct gacgcctcgg taataaattg atttgatgat 63900 gtatcttgat atcccctggc atcaggcggc cctaaaagag taagagctga cgctgtatct 63960 tctttagaag gggcagaaat ttcaatttct tccaattttc cttcaagggt cgtggtccct 64020 ccctcctcta tatctagcag agctgatgcc gcgccaataa ctttaactac atcttcaggt 64080 tttggattag atgtctcgag agcagcttca ttatctgaaa aagttttcca ggcttttacc 64140 acatcgcggg ccctttttac cccgacgcct gcgagtgaac gacataatgt ccacgaacgc 64200 tggacgacag tattcctcgc gtccgctatg ccagataatt cttcagctac tttcctacaa 64260 atgtgagagc gtgtttgagc attacccgca agctgccagt atgtggtctc aagtgcatgc 64320 gttttaacct ttgtggaatc taatgcccga atagcttttt ctgtgtgccg gattgcagtt 64380 tctgcaaaat tgacggcttt ccatatggcc tgcattacag tatcgtcctt ccagtgtcct 64440 agttcttttt tgtcacggca acttgagaaa gaaacattgc ccaaaaaatc cgcatttgct 64500 gactgtgaaa gcagtgttct tatggtagca gtcttagaaa gtagtatttg cactgcagta 64560 gatatctgca tagatgcgtt atttagagtc ttggaaacct cctcaaggtc tctcgttgca 64620 gcttgctcga atgcctggga aatgaacttt gatctcatgg tatcgacggc agggacaggc 64680 tggactgttt tcttaaatgt ttctggaaga gtgtcgaggc tcctgtcgca tgcgtcagaa 64740 attttaagca atgccttttc tatcgcgctt gcactttcga tggatatctt ttctgtcgga 64800 ttggtctttg taataaatgg ggagaccgct aactgaaatt ccaaaattgc tcgcctgtac 64860 ttctgagtat cagacaggtt ttctgagagc ccaaaatctc tagcccacga taaaagcttt 64920 accgcgtgtt gtaccgcgtc aacggtgaat ggataagttg atactgcgta aacaatgtct 64980 ctcaatacgg tcgctacaaa aagattggaa aagagttgca tatcgatttt cgggtccgtt 65040 ccattgcgcg aacatatctc ttcaggctcc gcgcccccaa cttcaatggc ctggactaat 65100 tctacggttt gctcaaatcc ataagtgtag gattgttcgt cggcactcgc atacccctta 65160 tctctggcct tttccctgcg ttcgagccaa tccaaatttt cctgcgtctt tcctcctaag 65220 tcagatatga ggcgttgtac aaaatcgaac accaccaaat ctccaagcgc ctcggctcct 65280 ccatcgctcc catctataac tgaggccaga gtgtccctaa tgatgtttag agcatcttct 65340 gatggggctg gggcaaatga tcgtagtggt agtagtagtt cgctttcaga cacccctacc 65400 cgccggagaa gatgcgaata tgggtctaca aaatcagata taagcccagc gtaatgccct 65460 gaatactgta gcgtccgcgg attatatgta tacattgagt gcgcagcgag tcctataagt 65520 gatgtatata caacggctcc taggaaatct ccaatgattg ttccgtcagt atcttcaccc 65580 caaagcgcct cagccttttg gatatacagt tcgcagttgc tcttggtaaa ccccctaagc 65640 actaaagtac gaattacttc ctctgggcca ccggtagcgg ccaagtccgg caaacgcgcc 65700 atcatatcgg cggtacttgt tgtataagca gttagggtct ccttttgttc ctctgtcaag 65760 ttattaggcg cgtcctcgaa aagctgtacg atggttggga catctagggc gaggcgttta 65820 atgggaatag ttaatagact atctaagtcg tgccgccagc aaactacatg tccaggaaca 65880 tgcgtcttcg gaggatctcc taacacgagt agtgggtctc gactgtatgc agcattggcg 65940 tacagttgcg agatagaaaa gtatcttgag tccaaatctt tagcgatcca tgacttggcc 66000 gaatctgtgt ccagatcaaa ggcagctagc gccgtctgtg gaaacttccg ataagggggt 66060 tttactgtag gttcaaaata ctctctgacc atagagaggg tcatcagcgc tttagttttg 66120 ggtagcccgg ttgaagccgt gatataattt aacattgcat ggtatcccac taagccttgt 66180 agctttgttc caagatactg tatcccgtct tgaaccattt ggtggtcgta taaaagtgga 66240 taattttcaa ttaaaggaga taggagtttg gttggctcga gtcggtctcc ggatgtctcg 66300 aacaattgtc gctcgtcaac taccaatctt gccaaactcc caaattccgt taaccagcca 66360 ctaattagac tccaatattc tacatttgga tcatttaacc caggaaattc tttacgtaca 66420 gctgtttcta ggtcatgttg cagtccagta aatgcttctc tcaaatattg aattattctg 66480 aaatcttctc cagagttcca tggaacagat atgcggctaa taagagagcg tgcaaataat 66540 ttcaatgtaa cgtccgctac tgccggaggc gccattgtgc atgcgagcat tatagtttca 66600 accatgtttt tcctagcttc tactttctcc aaatcttcaa gtggaattct gtttctggag 66660 attagaattc cggtgagggc tgaagtaaca cccggaactt tactgcagtc ggtgtgtaca 66720 gcttcaaggc aagccttgag gctatccgtg atggcctgca tggtttcaat agtcgcgtca 66780 actcacggaa ccagctggta gctttatagg cacgcttctg aatgctttca cagcacagtt 66840 tttttcagaa gtgtgattag agctagtgtt ctccagctta taataagcgt cagaacttcc 66900 tttccgcgct gttacatcgt aagcatgtcc ggattacttg ctcgcaatgg atcgaacgat 66960 aaaattcgag cgccagaaag agggctgagt ggattcgcaa acactcgcac tcatccttat 67020 ttacaaagtg tacttcctcg aagaactcac cagcataatc tgttatcagc cgcgctgggg 67080 cgcctaacaa ctggccggaa tttttctcat ggtcttggaa cgaggccagg gaaattcttt 67140 attggctcgg ggccacgtaa ccccgaagaa acaaataatg caacgcttgg aaaggaagat 67200 acaagggcca tcgcatctaa aattcttctc gatgttgaat ctacgaggac aaatgatgta 67260 atttctttaa cccaaataac tgtcatagac ctctgccagc caggggtcga agagtctggg 67320 tctctaatgc tctttttgaa aggggttaaa gacttactca agattttggg atcacgaccc 67380 gcccgcgagc aaattgtgag agatttagag actgcattta tcaatttgaa ccgcgcctgc 67440 ggcttatcgg ttactgggga gagtgctgtc aaatccttcg agctttcagc ggtgtctttg 67500 agttttgtag ctgcggccgg cgcggctcac taccgaaata attgcggagt agaggcacta 67560 cgcgcgttcg taatcgcgaa ttataaggat tccgccatta ccgaaaagct tgccaatttt 67620 gatgcattgc ttctggcaac aattgaggca cgagcgtacc cccatttttt actatcttta 67680 ggtgggggct tgataaaagc taccgaaagt gaaacagtaa cgtgcatgcg actcttggtc 67740 agagggactc acgaagcagc agctgccgga gatctttctg agaaaaaatg tgccgtactc 67800 cacttccctg catgtctgtt acttgacctc gatgaaggtt tttgcccacc aaggacaaag 67860 atcaatgcag aaggcggtgt ttactttcta catttattat tcctgtactc taccgatatg 67920 ggacacccga gctacgaact atatgtggca aaaacatctc tccccgaaag ttgcatgaga 67980 gacattttaa atgaaagatt tacacgacgc agaataaata acactatagc ttccttaaca 68040 cacatgcaag ctcaagaacg ccaagccttt ccccctttta atattgcaga agctgcggtt 68100 gccgcgcgaa tggatctggg acgagaaaga tcaagacatc cactggatcc agttcaaggt 68160 cgtgatcaac gtcttaggga tatgcagata acgtccactg gaataccaga ccattcggct 68220 ctagtattcg ccgcatactg catgctaggg acggcgggca gtattggcgg agagccttct 68280 ttttctacta tccagaaaaa cgggactagt ctaaagtatg ttcacattcg cgattttaac 68340 tttaggggcg gcccatggaa tgtttgtatg taacacaccc acttctaaat aaatacaagt 68400 ctgttcaccc catgtgtcta ttcagttctc attcgaggca agggagcaag gatccctctc 68460 aggacaatta taggattatc tcctgagcag cccggagcca tgctttcgtt tttcgatgaa 68520 ctcgaaagca ttgcccatct agaagagtgt ctgcgggaca tcgaaacgcg tatgcgaacg 68580 tctgggtttg atcctaaatc catcattaga gacgattttg acataagggc tgggcgcgag 68640 ggcctcgcca accggatctc gatgcttgtg gacgggttta aagtttccgt gctatttaac 68700 gtagaactat accgactcct cgcggaactc gttcatttaa gaattcgcac aaaagcagtc 68760 tcattttcgg agtggctaga tactaggggg ctatctgcgg actgtaaaca atttattttg 68820 gaaaatgcag aacatatttc tgcggtcgtc aaagacttct acaacggaac ataccatcag 68880 cttgcaagag tcggtcttca gtcagctcaa aaatatgaat cgctgtattt gggaaaactt 68940 ggcaatggaa agctggagag tatgggtcaa ttttttacta gactctctgc tgaggctgcc 69000 agaggagctt ttaatattcc ccaatttgca caggcattgg aagttgatgg ccaggttaca 69060 ccggcagacg tctttactag gttttttacg tgtttgagta gccaactgat cgtacctcct 69120 accccagtaa tgcttttcgg gggtacgtct ctggctgctt atgccagttg ttttttgata 69180 gattcatctg gcagaaatac aagagaggcg ttcaatgtcg ttgccgaaga agtaattccg 69240 atcatgaata atcgcggagg aattggaata tcactgccgt gccttggcgc tccccaaaat 69300 gagtcggggt gcctgggatt tcttaaggct ctcgattcgc tagtagccgc gagcaacggc 69360 gccgcaaagc ggccaacagg gctttgtgtt tatttcgagc catggcattg cgacacatta 69420 aagattctga aaattcgtgg cagctcggcc gggaatgaag agttcagatg cgataacatt 69480 tttactgcca tttggatgcc tgatcttttt atgaaaagac tgcagcagcc aggaagtaaa 69540 tggacactgt tcgaccatag gggggagcat ctgtctaact tgtttggaga ggagtttgag 69600 aaggagtatg aacgtcttga aagggaaaat gttggagtgg ccactatccc tatcaccgag 69660 attatgtttc agataatcaa aagtgcagtt tccaccggca ctccatttgt cgtctttaaa 69720 gacgccttca accgtcacta tttttacaat atgcaacacc gagcactgaa gtgttctaac 69780 ctctgtacag aaattgccca catggcagac tccgatactg ttggagtatg caacttgatt 69840 agcatcaatt tggcggcaat ggtcaaaaat gctcgcgcag gacttgctgg gaaacccggc 69900 agcttcttcg actatgaact cttaagggaa acggcaagaa ctgcaacaat tttcgccaat 69960 gtcatgatat cacttggaaa catgccaagc caacgggcac agagcgggaa ccacaggtta 70020 cgatccctcg gtgttggagt ccagggactg cacacagcct gcttaatgca aggttttggg 70080 atgactagcg ttgagggctt tgaatttaat gacactgtgt ttgagctact tgccttggaa 70140 acaactggaa tcagctgtag attgtgtgag ctggggttgc ctccgtttga taaatataga 70200 gaaagctatt atgccttagg atggctgcat attgatgggt ggcccaatac gaagctgaga 70260 tacaaaaatg agtgggatag tctaagacat agaatagatc aatctggttt gtacaactgc 70320 caaacagttg ctttgatgcc aaccgccagt tcttcccaaa ttacagaagt cagcgagggg 70380 ttccagcccg tattcgggaa catgtttagt aagatctcta ctacaggaga ggaagtgcga 70440 ccccatttgg cgctaatgga tgccatcgac gagctgtatt ctgaccaggg agaaaaacaa 70500 gcatttctag caaacctaaa aaaacatcag tggtctgtgc gcgctgctct gggaagtgct 70560 tggtcagagt ctcacgtcct cgcgaaattt caaaccgcat ttgaactcga tcaggaaaag 70620 ttactatact taagcgcacg ccgcgctcca ttcattgatc actctcaatc aaacactctc 70680 tacatcaccg aagacgtgga cggtacttta agtgcgtcac gtgtatcccg cctactgcaa 70740 gttgccttta aatacgggct caagactgcc atgtactact gcaaggtgcg caagatcaca 70800 aacaacggag tgtttgtcgg gtcttgcgga gacagcctca tttgctctgc gtgtcaataa 70860 tcttgctaac atggcagaat atcagtccac agactattat tacttgcccc agtgtgatga 70920 cattcgcgag ctccgagacc tgagcatagc aaataactgg aacgaatttg aactatgcta 70980 cagtcgcgat gagaaagatg ttgatctact aactccggaa gaactagatt tttacaaatt 71040 cgtgtttgca tttctggcag ccgcagacga tttgataaat ttggatatcg ggaatctcat 71100 gactttgttc cctcacaagg acattcaaca ctattatgct gagcaaataa gaatagagac 71160 ggtccactct agaacctaca gcttggtgca aatgatcctt ttcaagggag accttcatgc 71220 gcgagacaga tatgtgacag aagctattaa agatcccgcc ataaagaaga agatagactg 71280 gctcaaccgt gtccaagtag aaacggatct gacacttcct gaaaaataca ttctaatgat 71340 tctccttgag gggatttttt tcgtggcgtc ctttgccgcg attgcgtttc ttaggaggcg 71400 gaatattttt gtggtgatgt gccagtcgaa cgacctcatc agtcgcgatg aagcggtgca 71460 tacaacagca tcatgccgca tttacaacaa ctggctcggg gatcacaaga aaccatcggc 71520 taaacgaatt caccaacttt tcaaagaggc cattgaaatt gagtgtaact ttttagcatc 71580 tagagcgcct caagcttcga gactcataga tctagaagcc atacagagtt tcgtgagata 71640 tagcggagat cgacttttga ccgccatcgg ggttcccact atttttgatg aaccgccccc 71700 tgatccgtcg tttcccctta ccctgatgtc gatcgacaaa aatgtcaatt tttttgagca 71760 ccggagcacc gcgtataatg gcaacgttat caatgacttg taaaagaaag ttcaaacagt 71820 caagcattat ataaataaaa actactcaga cagatattaa cattttatac ttgttcttgt 71880 tcattttttc cacaaataac ttctcgtaat gacggcagag gctttagatg ccccttctta 71940 ataagctcag aaaaatattt cggggcatca ttagaaaagt atttacacaa tacttcatat 72000 acagcgatca tgtcgagctg ttcctgaacc acgggcacgc gcttaagtag tttgtgtctg 72060 ccatttattt ctcgtgggcc gatgacactc aaaacgtagg acagaaactc gtcatttttt 72120 tcatttctgg cgccattatt taccgaagga tcctgagggc ggtaatcaat gtccgagtta 72180 ccatcgtcgg gaggttcttg aggaaactga gtcagtacat atacatagcg tccaggcaaa 72240 ggttcacgca catctgtttt tattccaaaa acatcactat ccgcaggcaa gaccccgcgc 72300 tgctcaacac actttttggt atcgttgttt tcattttttt cgtggtcacg ccattccgcc 72360 aacctggcag aaaatgagta tattgaatcg gtagaatgga tgttagtatg acagtccaca 72420 catgcattgg caaactcttc cccggacatg cccaaatatt caataatact tttataaaag 72480 atagcgactg gaaatgctgg ggtcagatcc gtaatcacat cacaacccat gaatactaag 72540 tcactatcgc tagacaggac gtacgccacc gtgcgggtat ggaatagatt ggcacatgca 72600 tagtcggctt ccattccttg cacatagacc gtagcaaatc ctgcggtagt tattaagtcc 72660 caacataact tgtagtgcgg aggacgtatt tttcgacgtg tcttgtaaat acaatccttg 72720 ggctccttaa tatcgctgca tcttcgcgcg gcaggtgcag tcggaacaga ttcttcctgg 72780 ctaaggtgtt taggttcctt gtattcgcgc cgacgcccac catcaaaaac aaatacagga 72840 tagcacgatt tccgactgag taatgaaaat aagaacacca aacttttaaa agttctctcc 72900 atgcatccca tatttccgtc cgggtcaatt cttcgcaaaa ttagaaaaag aacattccat 72960 gtgtcgactg ccagtggaag ataaaatccc ttctcaattt ttaacgataa atgaacactg 73020 agtccatggt ttcgaataaa gcgacgcatt cccaagattc ccatatcggt atatttcgag 73080 gagagcaaat gaaaagacag aagcccgcaa gtctcgtatc agcaaactaa tatttagggc 73140 gctttgaaag gcggtatttg tatgtacagg ggttgggcaa tccacaccct cgtaatcgca 73200 ttacacataa ggtgtgacat ggtggtagcc ccaaaatttt atgcacaggc tacagttgta 73260 tataaaccgc gcggatgttt aggagatgtt cagagacacc ggggaaggga acgaacgtac 73320 acacgaatta cgttcgttgg aagatggatt tggatactgc gacaagaagt aaatgtttgc 73380 tccgactaac tttaggaaag catgggattt cggtggtttc ccccattgcc aaaaacatgc 73440 gtgggattct gcaacactct gtgctggctt ttatgaatga ctgcatagta atttcctgtt 73500 ccgctccgtt tgggatggct ttcttaaaaa tcaagtggca attgttcgac tcatttgaat 73560 atttatcaga cgatgagagt atactaccta tcatgttcaa taatactata caccagcgcc 73620 ctggagacct cttggatttt ctgtgggact ctaagaaaaa aactgtcgga ataccaactt 73680 tagccacatt tactatatca gaaagtttca aatccgatga aactagggct gtactcagac 73740 tgaaagtctg tcgcgagata gaagagagcg cgtcgtgccc ccaaaatacg gaaataagca 73800 cgaaattcaa gtactcttca tcggatggac ctcctatata cctgcctcgt tccgataagg 73860 catgtcgggc ctcgctggaa cagtattcgt tcaatgaaat tacaaagtgg ctttcgaaga 73920 tccctaaaga taactcaatt acagtcacac tcacaagaga gtatgtcacg ttctcgtccg 73980 cagaagacga gcaacgccta acctttaacg cgaaatggtt cggcgaccag acaagtattg 74040 tatcgtctgc gtcaattttg tctcagctat gtggccatga acctgcgcct aaaaaaagag 74100 agctctcaag ccgagccatc ggtaagaaac taaaagaagc ccgcattatc gctgttcatg 74160 gggacaaaga tgcctgcccc attgtagtat cactctccag acccggatct ctgaaacagt 74220 cactagggtg gctgaaaagc ggtccttggg gaccaccgtg tcttacattt tacaaagact 74280 ctgtgaatag tcttggagta gaactctctg aaagaggagg agaagaatta gctgctggga 74340 tttttttcct ttccgcgttt tctgcagatg gagcaatctc tgagcaatgc catgatgact 74400 cagacacagc catgcacgaa tttttggcgg aggaggagcg cctcatacaa cagaccacgc 74460 tatcccattc caactcaagt aagaagaggt cgctcgaaaa ttacgaggac accgatatta 74520 gcccatccca ccacccacaa aagcggggga aattaaagaa cggctcactt gcacggaaga 74580 actaaaatcg tctcctcgcg tctaccgggg agcttagttt actgccagcg tttgtgaccc 74640 aagtgtgcac cgtgatttca actctaccgc aactatgacg ggggctacca taattgatcc 74700 attcgcaccg cccaagggta aatggtggcc gttcaatttg aacgggatag ttttttcctt 74760 gatgatgttt attatatttt tagcctggat actgtgcatt gactatggac tcgcgttagc 74820 ttacattacc tgggcaaagc tttctacgaa agaggcaaga ttcggatgga tgatcggact 74880 attggtggct acgattactg ccagttttct ggatattcaa tactcggctc acaaaacagt 74940 ccgaatttat tttctggtga tgctttctat ggcgagcgca gtaataatta tatttctcat 75000 ccattccaac agccccaatg ccgcgatagt tatggggcta ttctccgttt tttcggaagt 75060 ttgcttgata ctgattttgg gatttcaact ccgaccggcc attttctgca gcataaacat 75120 gacctggctc tttcttgaag ccatgctcct aaatttgacc gtactttctt ggaacttgat 75180 gcaccttcga gtaaacccta gatacttgga accgttggcc ctttttacta ttaacatttt 75240 ggcatacaat ccctctcgtt ttttgctcaa gagtgatttt tttaagacca gcatgataac 75300 tctgacgggc agtatagaac cattttccga agataacacg atttatacac ccccaagaca 75360 acataaagat actcgccctt cactgaatga cggaccaact cggtggtgcg gttactgtat 75420 tctcgtatct acaacattgg ttactgccgc tttcgcctgc acattatcat taccgttcct 75480 gggcaaagat ttaggtactg tacgcatcgg catgcaaacg aattttaaaa tcctcatggt 75540 agcgtgcggt tcggttttgg catttggatc tacttgcatt ggaaaactat gcaaaatcca 75600 tatcgttgta tggttcgtga taagcatact attaaccttc gtgtctctgc tatcactgat 75660 taagttgatt gaggacccag ctggcattcc atttggtgtc attcttgcat cggtttcttg 75720 tctgtttcaa gttggagccc tctttttccg agaattaaaa acggccaccc atacacaagg 75780 atggatttca tgcgcccttc ttttctgctc ccttttcatt ccaattgccg cgccgcttgt 75840 gtgtgagtac aagctctgaa ttcttgtcta agggagacgt gccaattctg acaacgccct 75900 aagccaacac aaatgccttc ctcaatttac gcgctagctt gaacattcca acaagatgaa 75960 tgcatcgcta acatggcttg ctttaacttt taaagttacc ttgagtttca gcctgctctg 76020 aatgttttcc tccaaaccta agatgttctt agttgtacga tttttgtatt gcgaatacca 76080 catcatccag taccaaagta ctaatggtcg gcaatcgaat agaaatcaaa catggcacgc 76140 aggagactgt cgcctcgaaa ctgccttcgc cgagctgcag aaattcggaa cgaggacatt 76200 agaaacagat ctacattcca ccgagcaacc gtttactgga gaaaatgcta gagaataacc 76260 taacaggcgg ccttcaactt tcactactta acaactggaa ctatattgtc gaggattgtc 76320 atagtcacga acatgatgca gtattgcttc ggatgcaatc tatattttga cattgttaat 76380 aaagcacatg tactatgcaa agtttgcatt cgtgtaattc gtcgagagag aaagttacaa 76440 gttcgattct ctcgcgctag gagtgtttcc acgtgcgaaa acgcaaaaat tttcatatta 76500 ttcgggcgga ctgtgtccat agtagctaaa ttaccgcgat ctggagacta gggcattcac 76560 gactcaacat gcagcatcag agtactgcgc tagtttcgag tatacttttg ctcttgagcc 76620 tgcaaagcct tgcgtttgaa tttttctgtg atccgccaca cgtttttcga gggcagctcg 76680 gtgaccccat tctattgcaa tgcttcagcg acagacctct aacccacgaa gaatctgtaa 76740 aagtagaagt aattcgacac ccagccagct tagttgaaac tgcgctaagc gcctacggga 76800 tccccccttc gctagatcca tggagagcta ctccaagaac tctctacaca tatgatgccg 76860 ctactgattc aatcaaggac ctaggataca ttggtgaaga tggaattaac ccaccatatt 76920 tggacgactg tcgttcaggt tttttcaatg tctctatcaa gtctagcatg agatctcaca 76980 tggcgcgtta tcagtggacc gcaagtcgag ggtctacaaa actaaatagc tcttttatcg 77040 acgtcttttt ggcaagacca cctacaactg tccgcatcaa atcagaagaa ctgtacgaag 77100 actcagataa ggcttcgcac ttaagtgttg aagcgcttgg cgcttatcct ccatctgctg 77160 cgctgggtac atggatgata cataatgcat ctcttgctga aaaatacagt ttagaaagaa 77220 gagttcttta tgcatcagga gagaatggat cggtggatca gacatgggaa ctggaaatac 77280 gtggagaagc cagccagccc ctcccttcca aaattcaatt tgtatatcga tggacccctc 77340 ctgaggactt tgaaatgcta cgacctgaaa ctcgcttgtt aaggttgact cccagctgga 77400 ttagcaagcc ccgcatcacg gtacaattcg tccctcctgc ctatgccctg tgtagagcag 77460 ctaatattat agacggccga ggatttattg aatggatcgt agataataga atttcgacga 77520 gcccacacca gacctttgtt ttggatgagc ccgaggggaa aaatatcgtt acactaatgg 77580 acgtcataaa actaccaccg gaggatacat ttcaatctgc ctctaattac gtgtgcgtca 77640 taagaggcta tgaacatgca tacagatatc tcaacgcctc cttaatgata gataatctgc 77700 caatgcggca aggattcccc gcagtcgctg cgatttttat tataattagt atcgcttttg 77760 tgggtgggtt actagttgct tgcttgggcg catggtgctg gaagacaaca taaacgctca 77820 tttaataaat gacattacaa acgtgcacta ctgtctgtcc aatttatttc atcggaaacc 77880 ttgcactggc aggtagtctc aagcaagcct aaacgatatt atagatttca atatttctac 77940 cagatccgtc cgatattccc aaatgattgg agaaatttct tccttagtca tcttccacag 78000 atcttcgatt ttgcgcccaa gctcaaaatt tccagtaatt tcagaaacct cactggccgc 78060 gtatgcctcc tcgtacaagt aaatgcagac gagagccgcg gcggttcgct ttgcagtgtt 78120 gaccaaaatt tcttgtggaa ttttagttcg aaggcacgct gcggtactta catctttcat 78180 taaacgggtt tttgccgcat cgaggagtac cgctgtttct gggattaacg ggatactctc 78240 tggtggatac gaacatctcg gtttgggttg cactttggga ttcaaacaac agctgactag 78300 tgcatcttgc aaaacatagt gcgtggccag caaagttttc aatatattga gaacaacttc 78360 cgacaattct tgtaattgta gagtttcggg gctctggatt tttttgagcc cgcttttttc 78420 aatatatctt tcacagacaa ctgtaatttc gtcaaagtga caaggatagt gcccgagcat 78480 aagtaaataa ttaaacagag tataaggaat cactgagctt cgcccgaatg atgctttgct 78540 gaggcatcgt tggccagggt atggcagcgt gaccagaatg tcagcctcgt cgcgcaatgt 78600 acttttcagt tttgctccat cagtctccca tgaaagtccg atagttgcga gaagtccatg 78660 tcgtgaaatc gtggccgcat ccacgatcat taacatcttc cagagtcgct ttaatacttt 78720 ccaacattcc cagaaatttt ctacatcttc gtcgaacatt tggtcggggt aaatgtgttt 78780 cacctgcaca tgatctgaga ggatagtttt tttcttacac ccacgcaggg cttttttctc 78840 atttcctact gcgaccgtac taatgatttt acctcccgta ataataatag gagtaaaaat 78900 ctgtgattgt tcatgaatcg gttctcttgt tagggagttc aagaataaat cttctaaatc 78960 ttcttctatg aacttcggca gagtagtaat atgtgcctgc gttagcacca gcgcactact 79020 atctacttga tacctaaatc ctgtcgtcgt attgattaga tccggggttc taaataacct 79080 cagtacttta ttcctcagag agacttcccc aactcgtatt tctagcgttt cggaaacctg 79140 caggccgaca aatattttgc acaagatcgg tcgtctgatc tccacggtaa aattatcaat 79200 caattcatca tgtggagatt ctgaaatttc accaagatga gaagtaaaaa tgtattcttc 79260 ctcctggcgg tcaaaaggca tcccattcaa acgattcagt tcagtgttaa taatcgcaca 79320 catggtaggg tgtttgatcc taaaaccgaa tttggtaata ttttttatcg gcccgcgagt 79380 agagatcgag tagatgcatc ctccatagat aatgtagagt cgtccgctgt ggtgatctat 79440 gtagcgtgca ggagactttg atccgcgctt ggagacttct tgaaaagcca cttccatttc 79500 agtccttctc caaagagctt gcgcgtcaag tgacggtacc gctattggtg ctttaaaagt 79560 atccgccctt tatactgctc caattctatc gtagcataaa gttttgacga tcatacagcg 79620 cctgcgtctt ggcaccacct acaaccaaac ctgagctctc cttcaacatg acaactggaa 79680 acgaagccaa ttcaatccgc ctctcttcag tacaagtacc gggaaattgt gagattgaca 79740 agctgttggc tggatttgac tacgaaaaag aacgtgatgg tgactattcg acactgaacg 79800 aaggatccat atttctaaac gatcgcctta tagcttcggg aagtgaagat acatctgatc 79860 tacaatatac gcgaatgagg aaacaaactt tttatcctag tttagccctt cttttaaaaa 79920 tactctgttg tctgcctttc ttttggtacg ggaattgcac gcgagagaaa tatttatttg 79980 taaacgctct tattatcact gccctctcct gtctagaagg actattgatt tccttttttg 80040 tgtaccgaaa cgtgaaggct gatcgtcttc ctttaaaagg tcctgaaaaa ctcattcaaa 80100 tggtgttatg tatgataacg gctatatatg gggcgattat cttttcaagg cacctttttg 80160 cggacgatga ccttgctatt tcaatatttg cgaaaaactg gacagacaca caggaagcct 80220 tgagaattgg tcattgttat ctctctccgt atttttcgat gtgggctgcc tgtctgtact 80280 ttataattct tctatacgac gttattgacg tgacacttcc tcttttgtgg gcctggacaa 80340 tattaaggac agcaataagc ttctaaatcg ttttactgct acacgaaatc gcaaagttag 80400 gtggaaggat cgcgttactg gcctcataaa ccccgccttg aagcctcacc cccggtaaag 80460 acacgataaa ggcagagact gcagtattat aacgggctga cttcgtagga taaaggcaac 80520 ctacaactct gtgtgctcaa tatttagcca tgaatcctga caacgggatc ccgcataaca 80580 gtcatcatga tcgcgcagca ttcccaagat ctgctgcccc tttcgtagca tctggggaac 80640 tgttaggaat tcttcgagaa aattgccatg cgcatctata tgaatggata agccgcgaag 80700 gggattgttg ctacagacac agctttgata ttctgctggg atcttatttc aatacactaa 80760 cgctcaccaa ctttctagaa accggacttt cagttgcatg tatttgcgtg aaatttccag 80820 agttacgcta tgcagaccga ggaataatcc agtttgtagt ggctaatccc atgattgcaa 80880 gaagtgattg tgaagtacct tctcggccat catttaccta catcagtaag agatggtcta 80940 ggacgacatt atcctcatcc cttgtgattt gtgcaccagc tctgggcttg ctaagtggcg 81000 agtcacttga cgggaccgaa atatctgagt tttctagatt acaggcgtta aaccaacttg 81060 cacgaaacct caaactaact ctagactcat ttgaaagagg aacaataaat catgtgctga 81120 gaattctaat ccgaaaagct ccaccacttc ctcttctacg acccatgatg gcggcgttgg 81180 aatgtgaacg agaaatgtct acggttgcca gagcaaatat tatctccagt atgaaggcag 81240 ccctatgtga agatttgttt ttcatagata aggagagggg acacgagact ccggatttcg 81300 cccgaaagct attagcctta attaattgca cgcttcctag tgtaaccgat gctcgtgtta 81360 cacacatagg tccggatggt cgacttatag aaggggtgat tgttacaacc gaagccgtaa 81420 aaggcctcat cgcggcccgc cttggcatcg aaactgcccg tgccaacgtc ccggcaatgt 81480 acagtgagat ggtattatct ggaaatagcc ttgtaacggc cttactgctg gggaaaacca 81540 ttcgtaactt tgatgaagcc gccgcaaatt tgttaagctt tttggacggt gaaaaaaatc 81600 tcgccgattt tccagaaata ccgtctaata acgcagacca agttccaaca atgtccgtca 81660 aaatgtccct gctcaacgtg ggggaccatc ttgtcagcat agaagcacta gagcgtgttt 81720 acacgcgcac tggagttccc tacccactct gtgaaaatgt ggatctgaca ttctttttcc 81780 cacttgggtt gttcaaacct gcaatagatc gttattccac atctgagatt gctcctgcgg 81840 tcggagcccc ggattatcgc cagtttcccc ctacagaaat gtactttttc aataaggacg 81900 gcatgatggt taaactcacg tttgaagact cattgccaac cgtcgcacat cccatagcac 81960 atggaatgct ggaagctttg gcagaacttt gtcaagaacc atgggtttca aatcgcagac 82020 ctgctccgat ggggttcaca attcaacgta tcggactaaa cccacctcgc ctgttaatga 82080 tcgaattctt ggaagcggta gcacgtactg cccctgcacc atacccagac gcaactttaa 82140 tcaatcggaa aaatccagat caattctcta gccataccaa cccgttcctt ccattagagg 82200 ttcacccgtt ctatgatgtg tacagagttg cgcaggatct aactattccc tgtgatgaac 82260 cattgttttt cccagccgaa ccaataacac tggccgcctc taggcgactc tgcaacgggg 82320 atattccgtt gccgctgtct tcagtcgatt ttagacttgc cagggggtac tgtatcgctg 82380 caggaagaca cagactgcac ccttcaacgg acgcagccat agaaacaaca ctatctgatg 82440 tgaattaccc actggctttc tatgtaattg aagcttgcat ccatggcgat gaattgattt 82500 tcatggaatc gcagaggcta gtagcgcagt gcatcaatag ctattggcat acatcaaggg 82560 gactagcttt tataaacagt tatccaatgg taacgtacat ttatcacaac atgactggaa 82620 tgatcgatcg agattgccac tccagatatg cggatgtaat gggcctgctt cacgcactga 82680 gggaaacaat cagaaattat actctccctg cggaaccaat tctcctgcgt tctcatgagg 82740 aattaaacaa tctcatgacg gacccggcac tttttccgcc catgatttat gactgtgatt 82800 ccatcctaag ggcacgcact gcatgcgcga ctagaggggt tacgatctcc accttcggag 82860 agagagcacc taccgtttct gtcagggaat atccagccca agtggatttc accgttctta 82920 gtaacactct aaatcacggc ccagcatata ctgctggcgg aagacatgaa ggaggaaccc 82980 atcatgactc cgaatggaca gtactcagca aattgtttta ctatgttttt ctacctgctg 83040 tctctagagg gaggtgttgc agtgcaggag tcgagtttga aatgatctac gatctcatta 83100 acactaccag acttccagat acagttgatg aaatggacaa tcaggcaggt gccgtcgaca 83160 gaggtccttt ggcggatgaa aatcttgccc ccgaatcctt taacactttg ttggcaaatg 83220 gatccataaa tctggtggat aatgaagctc tggtagcatt tatcgctgcc gcacggcgcc 83280 gtcaggcagt acacacgata cctctgagag ttaactattt acctgacccg ggcttcgaaa 83340 ctatagacag cccgaggaat tttttggtag acggagtctt atacaatgga ataatcatga 83400 tgaactatgc tcaatatgac gcgacagcta ttccatctcg ctatttctat gcattgcctg 83460 tgaatggatt ctttatgaac cgtactatca tagaagcatc tcacagggct aacgtcaacc 83520 ttactaatgt acctgaggac ttgccactag ttcctacatt tttggggagc gaagtgtatc 83580 gctccataag agcaccgtcg tacctatttg cttcgagagc ttcaaactat gcctcaaact 83640 cggtcgtggc atacagcttg ctggcaggat acttcaagac gtctcccgtc gcacttgtcc 83700 atcagttgaa attaaatctt catccagggt ttgctctcac tgtcgcccgc caagacagat 83760 ttgcggcgga tcaaatttta tttgcccgaa gagcatcgga atcttactat ctaggatctc 83820 cagttgtaac caaccgccca gagaatgatt ctctcgtaat tgagataagt cagccaaggg 83880 ggcacataga tatgggtctg ggatttacag cgagtcgtgt tcctgcaaaa attaatacag 83940 tggttacaga catgggcaat cattgccaaa atctcttcaa tgcccgctac cctggtcagt 84000 ttcgccatgc ggaagttgcg gattttattg cctctgaaat aacagacaat gactctacag 84060 ccttgcctag agcgcagcct cccattctgc tgtcttacga aaaggcaccc atcccccctt 84120 gcatagagcg gggacagctt gctacatgtg agtttctttt aactccagtg actgccgatc 84180 ttgcatattt ttatacatca gcaaatcccc gagggcgcag cagctgtatc gcgtgcacca 84240 actgcgagga tccatgcgcg agtgaaactg aaaaggctat gtatgaccat tctaccccag 84300 atgcagcaca cccgtctagg gctacgaata atgcttgggc atcgcaaaag tattcagtgg 84360 gagacaaaat gtataatgcg cggcggggtt ttattacggc cagtgatttt tacagtcctc 84420 tgagcaagtt tatgacgcca tctagagctg aagataagag tcggtgcctg gctcgtttga 84480 tgagagattc ctctgcggca attagttcag ttacgggtga cactgagtat caatttgtcg 84540 ccccgcccgg tgccaacgaa ttagtaactg atccgtgcgc aatgtttcaa gaagcgttcc 84600 cacccctttg tagcagtgac aaggtcctct tcgcaaccta cgaaggccct aatagagcat 84660 ctggatctgg tgcaagagaa aaccactttg cgcagtattt gattcacgat aagtctccaa 84720 tcgccaatgc gttaaaaacc ccatgcaaca cgcgtcgcta agacggaatt cgcaaacgat 84780 ttctacccgt gaaatcacgt caccgcctgg tctgtttggg cggagccctt tcaaaacttc 84840 ttcataagtg tttcctgtgc agatgatttg cccacggagg gatatatagc gcatacctaa 84900 ctaaatttca gaggacagaa gtacagatcg tatcagccag aacgatgaca agcggacagt 84960 acgagatccg cgttgttctg ccaaatggac tgacacgaga tgaagaagat cgtctcagaa 85020 gcttgcgtgg gactatttta atggcgccaa ttttgcgaag gtgtgttttt ctgcacgaaa 85080 tcgatcaaaa atcatttttc gcccatggaa aagaaccaga ctatgcaact ctgctcacag 85140 cctacaggag acgctttccc atattaatag tttgtgtcga aaaccgagaa ttgagcgcca 85200 tcgcgctatc cataggatac ccgcgcggaa tcagcgtgcg caacactggt ccatttagtt 85260 tgaacaacgg tgatctcgtg tctttactgc cacccattac gaatacgcgt tttcgcgtcg 85320 acttgccatc ctgcggctct gtaatcgagc cagccatgac aattcctttc gagatcggaa 85380 cagaactgat gggaaagatt tttgcaggga tggcctatga cttctgcgtt agaaatcaaa 85440 tagcgacaac ccgtcctcgt gatatttatg ttgtaacata taagaacaag acactcgatc 85500 tatctacatt gcccccgtct gatgcggctg cacttcaaga tacaatgaaa agcctatttt 85560 catcggttct attttcgata cacgaggggg tcatgtccgt tttgtcacta atgcctgctt 85620 tattggcagg aggggcgaac gatccatttc tcaatgccat tctacaaatg caaagcatga 85680 ccagactttc cgtgcagctt tttaatccac ccgcgctaga attaccggaa cctgctggca 85740 gctctgggcg atatcatgta tttgatgctt ttgccgcgtg gctttcaatg tctcaccgac 85800 ttggtgattt attcaatttg aaaccggtcc tcaaagtagt aatgttttac tcggatgatt 85860 ctaccgcaga cgagggagac ctcctcaacg ccattgtacc ttaacccgtc tgtgcatctc 85920 tatgaaatga cgagacatca tatctctttg atttgtgaat aaagtattta ttatcgaaat 85980 tgaatttatg ctagtctctg tcttctaccg atcggtgcga tggggtgata tccggcagtc 86040 ggggaacctt ctagtgctaa gtatgtagac attacagcgg ccactaacat gtcatcgggt 86100 acgcggccct gcttaccgct aaaagttcga aaggaatcgg gcccttggcc atgagtaaca 86160 gtaatgttcc ttatttggtc tacgagatac tcgcatggat ctttactgag tacaagggtg 86220 ttcgagacaa gttcctggga agccataaag cgcccagagt taaataggct gacaaacaag 86280 tcaaatgctc tgctcttttg tttgtttaga agataaaaag ggtgagccat tgcagttcca 86340 ggctgccgac tgtgggcaaa agtcagagaa aagcctaacc tcctacgcaa agaatccaaa 86400 agctctgtca agttgccggc tatggcagca gcagaatcct gactcgaatt cccctccacc 86460 gctatacgaa tttctcgaaa tgcgccagcg tgaataagac aacagtatgc tatacacaaa 86520 tacacgcact gggcaatttc cagcgccgcc tctccggtca gtgcatccaa gtaaaaatgt 86580 tcagctccca tgagaaccat agagtctcgc agcgcagtca ctaatgctat gccagtacca 86640 gatgcgcttc tgtttgtggt aaatgcagga tctacataca cagtgagaat tttcccgagc 86700 ccagagatgt tgggtttact tgaggtagat ggtctgtaaa tcaaaaactg atccaaagct 86760 cgcacaggaa caagtgtacg atcggagtca tattttccag cacgtccacc ggcaatctca 86820 tgcataaacg aatcttttac gaacaaatct gcggtatttc gaacctcgct gtccatacta 86880 acaaagactg gtttgtgcaa aacataacaa gaacaggtag tcacgtctgt tcttttctgg 86940 atttcaggca tgtgttcgtc gcatatatag gtaacaacat taagcagaga gtttgtcttt 87000 cccttaagat tgtacagtag actcgtgtta ctatggcaag tgttggtaga agatacgaag 87060 aaaagtttgc agttagtctg attcaaaaac cccatcaccg tgtggagagc agccggtttt 87120 ataaaatttg cttcatcgac gaacaggaaa ttgaagtcct gccccctgag accctgcaaa 87180 aacagaccag caataaaaga tcacactcaa cggacatgat tcattcacca gcgcgtcgca 87240 atggaagtac atgtcttagc agcgacatcg aagctattat cttgcggtga acaggaggga 87300 ggtcctgcgc cgatactaag tcacctagtc ctgtccacgc agtgcttaga aggatttgaa 87360 gttccggttc accttcttag tgacaataag ttttatacag aaattcaaat tcgacaccac 87420 ggatgttttg actgcacaga gtggaaacaa gttttctcaa cttttgtcgg acaccgggca 87480 ctcgacaaaa ttctattacc tgagttgggg aattgtcaag agcgcccctt tcgaattacg 87540 tatgatggtg ggaatgactg gggaggactg ttcatcacta tcccggtata ttgcgacgca 87600 gaaaagatga catatgatga ttttactgcg gtggctatac gaatagctat aggagctgcg 87660 ttggaagaat attatgaact tctattcacg tatggagagc tggtaaactc ttctactcgc 87720 tacaatgtag acagtgccag attagaggcg ctttcgtgcc agctattaga gtactctcca 87780 tcacatttaa atgaagctca aaccaagtat tttcgcgata ttaaaaaacg gctctccgaa 87840 ttactcggca aaaaccggca atatgtaata agcgcagctg aatatctctc aaacaatcta 87900 caacgatttg atgcgccacc ggacacgtca gccaaacagg ctactataaa agaaaggata 87960 gacgagtcta cacatctctt gaaacaggtg gcaggcgctt ccatgctgcc catgaagaag 88020 tacacccccg ttccccaagg aagtgaaaat ttgagggcgg tggcccaagg gttgagcgct 88080 ctcgtaaaaa cgctagggac ccgaggcact gaaaagatag cagatgctcg gttttcatca 88140 aatactgcaa catctgaatt agagccacca ggttgcagca gaggtttcga aaaggcggca 88200 ccaccaatgc ctgatataag aaatgttatc atgacagaca ggcaaaaaac cacaatgtct 88260 attacatcaa gatcggtaac ttattatact atgtatgatt gtctggcagc agcctgtgaa 88320 atcatggagg cagaaaataa ttctaccaga agatcatggt cactcggaaa aatctcaatt 88380 gtgttgatgt cgtgctataa ctctggagct ccaatcatgg ttgtaaatta ttcccaagac 88440 tcgttaaagt tatgctatcc aaaggttaga tctggagctt caatactagc tacaataatg 88500 agaccgctgg gagaaacctc agtacaaaat ttaaccgaag cagctcagca agaaatagtg 88560 aagaatgccc catgttttca atgtcctttg aaagctttga aagatccaga ttctctaact 88620 aaattgtttg cagtggactg tgaacagttg ctcctttata gtttccaagc gcgcgtggct 88680 gcagcattca ccgcagcggt gtccgaggcc attgtacgag caactcacac agagagcaat 88740 actactcggc tcggacagct aataaactac gacatccctt tataccagcc atttgacagc 88800 ttggaagcaa actggccaac acaaatagca cgtatggctt cagacctaat ggcagttctc 88860 tgtataactc ttcaaagtga acgcttgtcc gtctttatga aaagtggaat atggcgcgcc 88920 atcttggcaa tgttaattcg aaaggaaaat caccgaagac catacctggc ccctgttcat 88980 gtggaggatg acgtgtacct attcgattat ttcagattcg gatcgagtaa tattgtaaga 89040 attaccacag agcctgttgt gttaaaggct cgcaaaccca aaatagacgg cctctacgaa 89100 cttgatttca tcgctagtcc cccctctggc ctccacccgt ggactaaaca aaaattccgc 89160 ccaggagaat ttcactccta tatatgcgtt ggtttcaatt cggccctgaa tgctcttctc 89220 atctttcctg gagggtttgg attagaattt gattttggcg aagcactaaa agaagtctgg 89280 gaggatcacc tggatcactt agtattgaaa cgctttagta ggcgtgcacc atactaccct 89340 gaatcttatc tcccgagctg cgaattcatg caaaagataa acacagctgg gtagctagaa 89400 attgcgccat tggcacgtct gcaggcattc ttgcttaaat gtaatagcgt aggacataga 89460 aagcagttaa taccgagtaa ttaacaatta gtggtcaaat ggattactgt taggactagg 89520 taaatgtaca gaatacttac attcgtattt tgactggagg cgaagacaat cgcacttttg 89580 tttccattgc gaaatgtaaa tgtgatcgtt tcccccttga cctgttctac ctgttttgcg 89640 ccaaaccatt tgtacaggcg agtaaaaatt tcaataaaaa cgggctctgt tgcttttctt 89700 aagtgggcag tgtatccaat gcgtattcct tcaaaagatg aaaccagtag ggaaatgagc 89760 ggaactaaaa accacgtttt cccgtgcctc cttggaacta aaaatacagt agttctttgt 89820 ctaaaatgtt gaatgatatt ctctgaaaat aatgaggtat taaaaacggt agacaagtat 89880 ctattacttc gttccgtgga tccttccccc aagcaaatac ttgacgcaaa gtatgtagca 89940 tgcattaaga tcattttttg aaataattcc agtgttccgt ctctctgttc gctagttgtt 90000 ttttccaact ttgcccgttt gtagtcattt gaagcttgac cagaaaatga cttttttaac 90060 agtgtgtgaa atctgtaaat aaagttgttc agttgggaaa attcatcaga cttgacaaac 90120 ccccggtagc cattcattat tccgtcgaat gctttgtcat gtattaggga gtcgcttgga 90180 gcaaacctgg caaaatttaa gtttgcgagt ttctgtctta gtgccggaag gatactgtcc 90240 tcggctgcac ctgtgaaaag ttgccgttta ggggatacct gtaaatcgtt tagtgcggca 90300 tcggtatctg tgtacttggt agaataggag gccagatttt cgtaaatgat ttctgacgcc 90360 atatatgaaa acgcacgcga aatagcacag caattatgaa aagatcctat aggggcaatg 90420 cacgcttgat ggcgctgtgg aacatcaatc gcaaattgaa atctgctcgc cggtgaattc 90480 atggtatccc tcgctgaatc attcctatca catatacttg cagtagttat aaaattggag 90540 tcactcattt cttgcccatc cacgtcgtct ggtcctcgtt ccattgttcg cttacgcaaa 90600 gcatcgcggt atcttttgac aatttcgacc gattcctttc caagcatgtc ttctgcgaga 90660 gactaccgaa acagggctcg ggccgaagtt atgaactaca ttaaagggca agcctataaa 90720 gctgcggtca tcgagatgat gtctctcaaa gttcctcgaa tgcacccagc tctgcgctat 90780 tttcttgcat cagctaggga gcaggaagct gtttcagaga taaacgtgcg ctcaaataag 90840 cgcctcagct ctgtcaggtg tcatgttgct cggataaaag cagctacaga gagtcagaga 90900 gcattaagac tggagttgga tggctacaga agatatctaa ggaacgactt tttagaaaca 90960 ttcgctcaag agtcagaagc cattgcagat gcggagctag acttgcagcg ggcagaagaa 91020 gaaattgctc tgtatatttc aggtgaccct gatcgcagag acagcttaga ttgtgaggaa 91080 gacgaccttt tattaaaatg gcaactagaa aacgtaaatc ctccgacgct actgccatca 91140 ccacatgcac caagtcccgt cagtcgcggg aactcgccaa gaactccacc gactcccagt 91200 ccaacttttc aagaagacga atgcccagta gaagaatact aagcaacgat gatggaatcg 91260 accttgagca tatagccccg gtctcagaag atttgacaaa agaatcgaga cagcttgcga 91320 tctacataat gccgaaacct aacaaaatat gtctcaaggt caatccaaaa atgagctacc 91380 gatggtttaa cctagaaggg tcaacggtaa ttggaaatgg tggatatgga tcagtgcagt 91440 atgccccaaa gtaccacatg gcagtaaaaa tatttgaatc ggatggtcat tttcgatggg 91500 aactagcaat gtccttgatt ctttccaatg cggcaagaag accagaactt tccgacatcg 91560 ccaaacattt cttacagatc tatgcctttt caaaaatcga gagagctttt gtaatggaac 91620 cgttgagcca tgacctaaaa acgtacgcca aaagatacaa agacaatttt acaatggaaa 91680 cattgaatac cctgacatct gagttcaaag gacttgcgaa ggccttggca tttctgaaca 91740 ttgattgcgg attggtacac atggacgtca agagtaacaa catactggtc aaatgtgatg 91800 cgaatggaaa acttagtcga cttgtattgg cagactttag tttgacaggc cctaatacta 91860 attctattct caaccagagc atgatggtgt gtccttcaag aggagtagtg gaagggctaa 91920 aaattataga ttcaacgact gtaaagaatc acattccatc tgactctttt atcatatata 91980 acggccactg ccgagctcca gaagtgataa taaattattg taatgggaaa aggtatcgcg 92040 accagccaat ggacgccctg gaaacacttg gattggatct attttccctt gggcaagtag 92100 tgcaggaaat cttatttgag ggaattctgt gcagatcgcg cgagttttcg tttaaaccaa 92160 aaccaaacac tattcatgaa aaattaagtc acgattacat gatgagggtt ttggcatatc 92220 gaattgtgct ttccgacaat ctaatctcta gaggctgtga tctaagtttc accggtccac 92280 taagtggaac agtagaatca gtgaacgcat ccctatttcg agaattagac agaatccttt 92340 tccagagtca cgtcgaaatg tatgagcgca tcgatctacg agaaaaactg ctgaacgtca 92400 tcattcctcc ggaaaccaga ggactttgta ccctggcggg actgctatgt cactgggatg 92460 cggatttgcg ccgctctgca gtgaccttct tttagagatt gtgatcgtta cttataccaa 92520 taaacttttt cagagctttg tattacgtcg tttttttgtg accggggact ctatcaaggg 92580 gcgtggttgc gcgataatgg ggtatatttt ggcctaatgg gtaacaggca gcaaggtgtt 92640 ccgttcacta gtcttcatct cgcagaggag aaacatgaca agtgttcaag accagtctcc 92700 tctgaacgaa aacatgcaat gccagaagac tttagaattg tcggttggaa tgcagattcc 92760 gaaagaacta ccaggagtgg caatgtttac attctacgat tacttagccg acctggcacg 92820 cggaggacac gcgcaaagtg acattcttca acaggaacca ctacatcacc gcctggctta 92880 catcagccac ctgttttcgt ggctcgaaaa agaaggtttc gcgtatggca ttttgaacaa 92940 attttttggt tctgagcgcg ctctgagcgc atcagaaatt agtagtaatt tatcgcaaca 93000 acagatcaat gaaatcttat ttttcataga atctgaaacg aaacaacaag cgtcgtgtga 93060 cctgtggaaa gttttaagac aatttttatt gacggcttca actttgaagt ggatgaaaaa 93120 taaaccgtgc tcaaagccgg aatggtttaa ggtacaggaa ttcaaaggcg gacaccttgg 93180 ctatgccaca cagtccatgc ctttgatttt tggcaatact aacgaaagct gcgcccgatc 93240 ccttcttttg ggatatgtaa ctggagaggc atggaaaact tcagaagatc gagaagagtt 93300 ttacaaattt gacgacggcc atccaccaga agaagcattt acatgtggac ttcttttaga 93360 taaacggagt ggaatgttgg gagcatcaat ggatatggcg atagtaaagc gcaggaaaca 93420 gtgcgctaga aaagtggaga tatacgaaat taagtgcaga gcaaagtatg tgttctcggt 93480 cgagaaccag acgcatccac tttctcaact gtacgataaa atgttgcaac acccatgtga 93540 aaattctatt cgcgatttct tgctgggaat ttcctcaccg ggggtagaat ttgttgaaga 93600 gagcggaatc cctacagcat cagaagctct actaacctgc gacaaaactt ggaaaactga 93660 caggtggaag aaaaatttac gagaacgtgc ttgcctaatg gaaaagcgtc acttgtccct 93720 gaatagaacc aacaactcat ctgtgttttt gtttgaaagc ccctgtctgg aaacaaacac 93780 gatcagacct gtccagtggc cggacggtga aaacaatatc gagttaccaa tcttcattaa 93840 cccaaaacat cagaatttca aacagatttt tgtacagaca tacgtcttgg ccgaatattt 93900 tgaaacaatt cctatatctc catttttagt tacatttata ggtcgcaaca gaaagacggt 93960 agagcgggga cgtgtattta agctcgaaca cacattagac ggtatagaag aaccggtgga 94020 attgaactgc aagcacgcga taccggtact actaataata acccccacaa ccatcgacag 94080 aaatcatttc agtgatttgg actcgcttgg cagagaagcg ttcgagtttt ctgtgaagga 94140 aacatgggcc aaggtctctg tggacacctc ggagaatgtt gctgcccctg ctgttcaaag 94200 tcctgcgggg gtgacacaag atcccgaaaa tctggagagc gcttgtccct attagacgac 94260 agctttgacg aattcaccat aaccgaagac atgcctatga ttcaaggagg aaaaaagaaa 94320 gagaagcgta gcaaaaaaga agccgaacca attgtagttg agccagtggc tgctagaagg 94380 cattgaaaca tgttatttca aataaacaga actacaacca aatacatgcg tcaaccttta 94440 tttgcgttat gcgtaatcta aattacagtt cgtcgtcata gggtacagtt tcataaacgt 94500 gcttgtctct tcggcttttg tatttttcgc ggcgcgtttt gcgtttcacg gttttatcta 94560 aagcttctgt ggcaacggtc gttaccttgc ggatgaaatc cgtctgtctg tactggtgat 94620 atctgtatgc ccgtacgact cgcagaatag ccaaaactaa aacaaggagg gcaaatactc 94680 ctagaattcc tgccgcagcc ggcttccagt tgggatgagt tccgctatcc aacgtattag 94740 catagtgcag ggatgccgtc ccaagcattc caagagcaat gatgagtccg aaatgcggac 94800 caataagtac atgcacatac ttcgctaaaa ccagctcggt cacaatcaag tatatgatac 94860 ctatgataag aaatgcaatc attgccccaa gtgtagaagc agggacactg actccaaaat 94920 tcacggtcat gacgagtgct ccggacaagg ccattataag cccccaaact cccatgatag 94980 aggcgtagac gtttaatacc actgccttaa acggtgatac aacacaatga acttcagggc 95040 atgcactttt gagctgtgag ttaaaaactg agtactggtc aggtgtcttt ccggaagacg 95100 cgaacgtacc caaaaatacg atgccggata caaaaataat gcaaaatgtg acagctgata 95160 gcgtaagctg tctgtacgaa aggagtagta caaacaactg ccacgcccat actgtgataa 95220 taatagacat taaggcaggt gtgctgatca cggccgaagt caattcggac gctccgtatg 95280 aacgatcgtg attacaagtc ttggctctaa ctgcgccaag agtaacgtat atcgccaaga 95340 gtatccacac cgccatagtc gcgtaaacgg taaatatcat tcctggcgac gaaataaaaa 95400 aaagtccatc ttcgttcgcc cttagcagtc caggttgatt gatcaaaggc gttgctggct 95460 taaggtgtcc accggcgacg ttgccgaaaa aacagggaaa ccctgcttgc ggactaaggg 95520 tggagaaagc tgaggccagt gatatcaaca ccagaaccac aaaagagatt acttcaatca 95580 gccacatgcg ccatgcaatc ctctctaaac gcgattcctg tccactatag tagtagccgc 95640 tcattttctg cgctatgtga attagcgcct acgtcgctca gcgggaggaa cgatatgtcg 95700 ccaaataatt ttgctcctgg agaacaactg tggttgtcgc ccagcgtcgg actcgcacga 95760 agactgtacg gatgcgatct cagcgatcgc ctattatcca atccgacaat gagtaggctg 95820 agcctagatc agcagcatgg ccatccggtt acgttcccac ccccctcacg ctcgcgaccg 95880 gtgttgattg cgcgcgctcc gatgggatcc gggaaaacta cggcactgat tgaatggttg 95940 gctggatttc tagaccacca ggatagaagc gctatagtcg tgtcatgcag aaaaagcttt 96000 actaacagtc tttgtcgacg attccaacgg gatggtttgg tgggttttgc tacgtatcta 96060 gactgcgaaa aatacataat agatgagatt tcacaccgac ggctattggt acaactggaa 96120 agtctgccac gcgtctctag tgtactattg gatcactatg atgttctagt agttgatgaa 96180 gtaatgtctt tgatgaatca attcttttcg cctacagtta gaaaactacg tgaaacggaa 96240 gctttgtttt cattattgtt atctaaatgt cagtatatcg tagcgatgga cgcaacgata 96300 aatgcaactc ttgttgaaat gctcgcagat ttgagagggg cagaaaatat acacgtgata 96360 gtgaatgatt tcgtatcgag cgggtttgcc aatcgtcaat gcacaatgct taacgcgctt 96420 ggcgcggcaa tacctgccag tttgttaaag ccctcagaag gaaatgagga caaaggactc 96480 gaggataaca aaagtactgc acaggtggat ccatctctac ttgaagggtc cttttttcat 96540 gaaatgcagg cgcgcttatt gcgtggagaa aatatttgtg tcttttcctc tacgctatca 96600 ttttcaaacg tcgttgcgtt cttttgttca gaaattctaa gtcctgggac agttctctta 96660 ctgaactcca actctcccca cgtagatacg actaactggg ggcgatttcg agcagtcatc 96720 tatactacag tggtgacagt tggattgagt tttgactctt gccacttcca ctcaatgttt 96780 gcgttcgtaa agcccacaat ccatggacct gacatgatgg ctgtctatca agcgatgggt 96840 cgggtaagac gtctactaca tgataagctt tttatatatt tagatgtttc tggggcatgg 96900 ggcgcaccaa ttttcactcc catgatttta aactcggagt ttagcactac cccatggcca 96960 gtagacatta cagttccagc agacgccatg tgtgtaaaat ttaaaaaccg ttgcagacag 97020 atcaacaatc atcgagacgg ggtatttacc cggttcaaaa ataagcatta tgtagaaaga 97080 tgtacactaa ccagtgctaa tgacagtttt agtctcctac atactcttct agtcaataac 97140 aaaataaatg tggagataat gagcgttgac tcctccgatc cgaaactgga aaatttgggt 97200 caattcatat ctggtctgcg tgcagatagt tatcggaata gggctccact taagcatctg 97260 tactccgcgt tggaaaagta tgaaaagagt caagatatat tttgccttcc atcaaaccca 97320 actcctgagg aaacagcttt gatgctcatg gagagtgaaa atgtaaacca gttcattgct 97380 cgtttttttg aacttgaccg atcgctagaa aatttcgggg aagacttgca agcctttctg 97440 caacagcttg gtgacaaaag caaaactata gatgcactaa ttaatgcggc tgttgtggaa 97500 acaggatgca cctgcgatga agatgaatgg tttcagatca atacagaggc attgtccaaa 97560 gatcgagaca gtaaactcga ctcttggata tcatattatc tcgatggtcc atttgtgtgt 97620 ctaagcaacg gacgtccggc cgtgattgag gtttgtaatg aaaccgaagt taagaatcgt 97680 cgaaacctat taagactatg cataaacatt gccaggacga taggctggaa accttcagcc 97740 gatccaaacg agactgaaat tgaacttgat gttatcgtga aggcagtaaa tgacgcattg 97800 aacgcaggga tggggaattg tatgctagaa tatcttcggt taaacataac agaaccctca 97860 tggttaactg gacctataag gaacctccag tgttatcttg gagaaaaaaa aatgtctcgc 97920 cgcgaacgga agacttctga cccactagag atggcagctg taaagatctt gcgcactcta 97980 tgggcggagt tatttgatgt acgggtattt aaaagccaaa agacatttcc tggtacggca 98040 agggtcaaga acttgcgaaa ggaggagctc tgtgctttgc tagaccgcat tcacgttccc 98100 tacgatcgca aggaaacgca caagcaacta tatgctaaac ttatgtgtca tagagaacag 98160 ttcaagggtt ctcgactaag tttccggact gctgcgtgga cccgtttttt aaaaggacgg 98220 tgcctggagg acttccattt gatgactcca atctcttccc atcatgtatg atgaaagcat 98280 actttatggc tacttatggg gcatctcgat atatacgatt gagactaaac aaaatgcgtc 98340 aggaaatatt acagacatgt gggtattgta tgaattagct gtccatgatt ctactaaggg 98400 tgcccatgaa gtactttatg catccttaca gtttgaagaa agcgacctca gtgtggcctc 98460 gtggcctcat ccagctctga atgccagatt actgacggac ttcgttgggg ctgtaaagaa 98520 tttccatcag agggtgtaca agctgaatgc aaaaacaatt aacttcggat ggattctctc 98580 atgttctact tctagccaga ttgctctccg cctggtgaca ggaagactac ttcatgaaat 98640 caggcgcgcc ttgactctgc cagaatttta ttctccttct attttttatg tttgcaaaga 98700 cagtggattg atcactaagg tctgcgagga taaatccaag ccacgtatgg caactgcatc 98760 ttacgcagca ttgaatgctt cgtctaactt ccaagcaaat tacattgaac gcaatctgca 98820 agccggacat tgttgtgaac tgagaaattt tggatgggct cgcatacagg caatctcatc 98880 tggaaaaatt aatccaagaa gcatgaccgc ggaatgggtg tgggctggtg gaaagtggat 98940 tgatggaaga ggaaatgaag cattttctga aacagggact gatcccactt ccgacgatgg 99000 ccttgctgtc ccctttgcct taacacccgc gaaaacaatt tatggaccga cgtggtttgt 99060 tcccagacgc atgcttgtag cgtcattggt gcccaaggag ttcgaatatg ccatctatct 99120 caaggatgga agtacgataa tctctttagt gtgcgcaata ataaatctgt attgcagatt 99180 ttaccaagga aacattgttg cacaatctac atttctcaaa cctattatcc tttttctatt 99240 tccgacaagt tcttcccgaa tggacggctc agagaaggtt tcatctataa aagactccta 99300 catgtataca cctggattcc cgagtataaa ttttgttccc attacgacgc agaacatgtc 99360 aaagatggga gccttgaatg catgcagaat agtctctctt gtggaggggt tatggccagc 99420 ctataatatc agagcattac tcatgctgga tcgcggagat cgagcgaaac atgggtctca 99480 gatcacaaca ctacccagag acctcgagag cactttagaa gtgtacccag ccggtaaaat 99540 atccaccata gccgatctcc cgactgttat cagtggcagg attttaaaaa tggacttttc 99600 tgctttcttt ccatgtttgt acatggcatg tggcggaggc agccaagcgc tatgccgcat 99660 tatcgaggca agattaaaca gggagccgca gtcagagaag cttaaagctg ccttggtagc 99720 tctggtgggc gggctaaaat atacagatcc atcgaaatat aaattagtaa tagcgctctg 99780 caacagcatt gcattggctg tcgaaaatgc tgccaatagc ctccagtttg gaatagctat 99840 ttatatgaag gatggattca taggagcttt tgataaacat tcctctacaa gcgcagagga 99900 actgagaagc aaatgcgaat gggccgccat tgaagaattg cagaagattc ttctagaatg 99960 cggccaagca attacaggaa tgccgactct gaaactaagg ctagagggag aatttacaga 100020 gggcctgctt cttaattgca acaagtattg gctccacaac aggaataccg gaaagagttt 100080 catatgtggg atacctgggc ttcgagaaga gaatgggctg agtgtgttaa cagaacgtac 100140 agcttgtgaa ctgctcgctg gcatttacac tgccaacacc gtaagcaccg ctaccgaaac 100200 actcacgcga attctagatg gatatgcctt ctctgccttc gaagctagag gtgacataaa 100260 cttctggcaa gagacgctaa aaagtagctt taccccatgc atttcagatt ccgcagccat 100320 cagatctgcc agtttcatga cacgcccaga tgagctggaa ggagagactc actttgttta 100380 ccttactccg acaaatttgt cctcccatgg ctccgccaac gctggcggta aagttatcta 100440 cccaagttct ctcgcagaag agaatttctg cattaaaata tgttattcgg ctcacctaat 100500 ccccaaaatg tcagcaatgg tggagcttgt acagaatatg gtgtggttaa aattttatca 100560 taattctgtg gacaatgatg aggagacacg gggtaagtta ttgaaaacgt gtgactacga 100620 ttacgagaga acatcttttt tattctcata attaaacaga acatttccaa agaccatgat 100680 acttggtact tcgtcatttc aaaaataggt atcatataac ttatatgcac tgcgatgaag 100740 cttgcggtca ttccaccaca atcttaatac gcgagtaaaa aagtttccgt tgccatatac 100800 ccgattcaaa gttgaattcc ttgactctaa gatgatggct cgttcatttt cattggaagg 100860 caggttcatg atcataagtg cgtgggtaga ataaagagaa gatattagct cttctccaat 100920 tggagcggta atttgcatga ggggctgcgc cactcgataa tgaggcaata ccaacccggg 100980 atcaaaggga ggaagatcat gcattaatag caatgtattt aagagccact cccctccatt 101040 caccaatagc tcgcgcacct tatcattgat tgaaatagtt cgcgcgaaac gggcaattgc 101100 gcttcgtaac ttatagcagt gttcttgagt aaccttaatg gggtcaatgt tttccaaata 101160 catgcaaatc aaacagagcg caaagtcttc aaatttttgg ggcataattc tgtgaatcct 101220 gtttaaaaaa tcaggccatg taacatgcac agtggcaacg cggtcctctg aggctgtgat 101280 tactgaaaat ataaagccag catgatcatc taggcgcaca cacgcgcaaa agtactcttc 101340 aatatccact actgctccag aaatcagctc taggataatt ttttccccat ccatctggat 101400 gtccatatat gttatggaat cagacgcaaa caatgctggc gcccctggcg tggatcgtac 101460 ttcaaaaaaa aatctcggga tagcctgccg cgatatttcc ttaattaact gtgatgtcga 101520 ttctccagag gaggccagac gttcaagttc ctcaagggta gggccgtgtt cgggttcttc 101580 tgcgatgtct tccaatcgta taggtcctac ttttttctga tgccggcata tcgcgttgaa 101640 tgcttcttcg gcccatgata ctaactttcg agtcggccga ttctctgtcg ctgcctctag 101700 aataggctct cctgtctctt tcagctcttc catcccatcg ttcatcttgc cgattggcgc 101760 acgaacgtct gacatttgct atgtaacgta cgttcagatc tttcaaatac gaacctaccc 101820 gcgagctggc aaataatgtt tgacacaact cctcctctga cttatatgta gtctggctcg 101880 atacaaggaa tcctagacgt gacgccttca gaactttgtg aaaaaatgga ccgacaataa 101940 gcgtgattgc gctagtactg tacgacaaag atacttcctc gccttgatta ttcatatttc 102000 tttgaatttt aaacacgcgc agtaattctt gttcccagag cgccgacaat cgagtctcct 102060 cctccagata aggaggaatg taccgcgcca gaaaactatt agcaatatac tgttggtcat 102120 tcatgtcctt acttacatca acgaggttat atgataaatt ctcagggagc ttcgatagcg 102180 actctagagt ttctttgcac tcccaagcct cttcgatacc tccaagggtc tcccatgctg 102240 ggcaacggtc atagtttgct tgggtgcgct cagtccgcct ggcagattcc attctagcct 102300 caaccaattc ttttttcatt ttcccattac tatagaccaa gtttttattg ctttccttga 102360 gatcagagac agtcttgaac aaagtattta ctacctttcc aacacttgta ttaacggcag 102420 ctcgcacagc attccccatg cgatcttctg cattatcaat gggccgctgc ccctgcgctg 102480 ccgctcttcc gccacaccca acacgggtag ggtcaagcac gagttgtctc tcgatgttag 102540 aaacattttc acgcaagtaa gagtccacta cgtctgccac atcaccaact ttgcgcatat 102600 tttgaatatc aataatgaac ttgatcagcc tagctgctgc agatgtaccg gcctcttcca 102660 caccttctcc cagagcctta tccaccactt ttgttacatg atctggatcc tgtgcattct 102720 cagttcgtag accaagcaaa accttgatcg gagcggtatt tactaattga cacaattttg 102780 catgctcgcg catagcctga gctttgagaa caggaccgtg caatcgttgc ataggagaat 102840 caaataatac tcccctgtca gttaccaatg gttcccaaac aaccatacat tccccaagct 102900 ccccagtatt tccatcatag gcgcggattt cactggtttt aacgttcatt attattagtg 102960 ttcgctcata ctctaaaata tgtactgccc ctaatacagc acggagatac ttcagcattt 103020 cgaaccctct ggcaaaaagt gaaggcgcga catgtaggtg gtggtgtatt tcagtcgttg 103080 tactttccag gtcttcattt ccgagatcac tgccagtggg gcgcttttct tgaggttttc 103140 tttctcgtac caaaggaacc atacccagac atgttatcca atctatataa cgtacgtagg 103200 aaggagcctt cccagcttcg cttaacccgc gcaagcttaa ctcagacacg ccccgtacaa 103260 aatcaagtaa cactgtctgc aataaaaagg accacaactc gaacgcctgc tctgcaactc 103320 gaattccatc ttccgaattg tgacagtaac gtgctgccag ttcatccggt gtcaaccctc 103380 ttgttctgat gtgagtgtcc caatcgcgct ccacatcctc aaatcgacag ccatccaata 103440 tattgcggag aaccgccact tgaatttgtc taacaacaga ttctgttgct cggaccgagt 103500 tatacacgcc ttgtccagaa gtgtacgtcg atgcgcccag gagaatttcc ctgaatccca 103560 tcgtgcgctt tgttggatgg attattatcc agtcatcagg ctcgcctgtt agaatcggct 103620 ccaagaccgc gataaggttg tcgatatcaa aagcacaagg tacctgacgc aattgggaaa 103680 atggcatgtc cattttcggg gaagagcagg cgggaaatag aaatcaccac tcctgtttac 103740 ttaaattttt cggcaatgca gagcattcag gcgattttat cggacattac aatcctatca 103800 gaacaagctg ttcatgaaga ctccaagccg caactgtctt ggtttgagac tgtggcacgt 103860 ttagatgaac cgaccacttt gcctctggcg gaattaccat ttaatgttta tctaatcacc 103920 ggtaacgccg gctcaggaaa aagtacttgc attcaaactc ttaatgaaac attgaattgc 103980 atcgttactg gctcaacgcg catagctgct cttaatatct tcaataagct atctgcctct 104040 tacacctctt gtcccattca tactattttt caaaactttg gcttcaaagg aaacaacgta 104100 caggctgtgc taggacgatt caagtttgaa aaacctcacg aacaacgttc gttggcagaa 104160 catcaaatgg ccgacattta ttattattgg gacgtgataa aggacattac tgcacgcgcc 104220 atagacacgg catctccggt agctttgtct gtccttcaaa cactccagca gaaaacttca 104280 cgcaaatttg taaaccttgc acctttccta atttcctcta tgcctccatt tgtcaaaagc 104340 aacattatcc ttgttgatga ggctggagtt ttagggaaac atatattgac tgcaatagta 104400 tattcgtggt ggctcatgaa tgcattgtgg aaaacgccta tgtatcagga cgggaagaag 104460 ccagtgatcg tgtgcattgg ctcccctaca cagacagacg caatggaaag cagcttcgag 104520 cacagaaatc aacgacacct tatatccagc agcataaaca ttttaagtaa tcttatttgt 104580 actcctacac tgttttcagt cctgaatatc aagaagcagt gggccatctt tattaataat 104640 aaacgatgct cggagcctgc tttcggagaa gtattaaagg catttgaatt tgggttacct 104700 ttgacaaaac gccatgccag attcttagat cagttcattg tatcagaatc attcatcaaa 104760 gatccatcaa agcttcctgg atggactagg cttttctcgt cccacgaaga agttaaagaa 104820 tacgtttcta aattgcacgc aaagcttcgt gcacagaaat ctgaaaaata tagggtattt 104880 ctcctgccga tgtatacaat agtagatatg gcggcatttg aaaagtataa atccctgacg 104940 ggtcaagaga cactaaatat tgatcgctgg ctgcaaaaca attcctctcg ccttggaaac 105000 tattcacaga gcagggatct agatgtgacc gcgcccagat ttgaatacca tcgagatgag 105060 agtaatgaat atacactagt aacgactgat gcctcgcacg tactcaatag ccagatcacg 105120 gtaacaaaaa aggtaaaaaa attgatcttc ggttttgagg gaacatttga aaaattcgca 105180 catgtattat ccgaagatag ctttctcaag acgtatggag aagacaaagt agaatttgcc 105240 tatcactttc tgtcgacctt gctatactat gggatgatta aattttacga atttctccga 105300 acagagggcc tccccgaaga taaattaaca atggcgtatg acaggttgta ctccctagca 105360 atgccggagc cagaaactca gaactttgac atgggaaatg gtgaaaaatt ttgttttaac 105420 gaagatgaat gtccgaatgc cgatgtgaat gacaaagatg atttattcga tatttttgat 105480 aagtcgttag atcaattcta tctaaattat gagatttgcg ggagcgatgt ccacggtcaa 105540 gaaatattta gttatttcga gcagatgaaa agaatttata ctttacgtta cgcggtgctg 105600 tgtgagctct ttgggagtgt atttactgcc gcccccttta gctcattcgt cggaacggct 105660 tctttctcaa gtcaagaaat ttctatctcc agtttcaagg gagcagtatg tgcatttgct 105720 gctcaaaccg acacatatac cttacgcggg attacgcgag caagatttcc gggatatgct 105780 gaggacacct caaaagccca cgaatgggcc gagccaattt tacaaatgct agacttgcca 105840 agacttgtcg taagggatca aatggggttc gtttcagtcc tgtgccataa caaagcaact 105900 tttgtcgata atataggtgg acaggaatta aggatggcca taacaattga ccacggaata 105960 agttcgagcc ttgcaatgac gatcacacga tctcaagggt taagtttaga cagggtagca 106020 atatgttttt ctcacggaac aatgaaatta aatactgcat acgtagcaat gtctagagta 106080 acgagtagcg aatatttgcg catgaactta aaccccctgc gaacgaaata cgaagatact 106140 cgacaagtaa gccaacacat tcttcgcgcg ctcagatgca aagaaacgcg actagtatac 106200 taatcctcaa aagtagccac acgcgtggct ttaaaatcag tttcccaccg tcgtttggag 106260 tgttgcatac cctcctcgtc ccgagaacat gattttcata agctacgtaa tggtaggagt 106320 ccaaggcttg gggcatggct cggccaccga atacgaacaa gtagtatact catgcgatgg 106380 aggaatgcgg tttatttgca tcggaaataa aatgtatcgc caccaattac cacccgggaa 106440 agtaatagta attcacaatc ccgtcgcaac aatgatcgct gtagactgtg aagaagaatt 106500 ttgcgcatac tgtttggagc gcaatggttc tcaccgagga ccctcaggag aaacattagc 106560 ttttcagttc tcggcatgtt ggtttctagg gcgcggagga acgcgagaac ggtggagcag 106620 cggcaacatc accatgatga attttttggg cgtcgctcac ttaactgtaa ccatatacga 106680 aaccccggaa gatctagcat ctagcgcgca caccaccccc acatgttccc aatcctctcc 106740 agaatcgctg gagtgtccag aggaaagcgt tcctcgagat cttgtagagt ttgcggcaag 106800 gcatgccgga ctgttagagg aataaataaa agtaataaac accaaattat gaaatacgag 106860 catttaatta ttgcgtcgca ttgcggaaat gagttgacct tcatagttgc tgtcacttag 106920 ctgcagctgg aggtagtagt gaggaaaatc gggtctcgaa atgtctagag ggtagctcag 106980 gcaacttttc cgacttcggt agaaagcaat atccattacc ctgtaacgca gccgtccgtg 107040 ccgaagagca cctggagttc ttccgtggag gctggcgaga catgcgggca aagtccatat 107100 cagttgcaat agcagcctga ccgtacttca tagtccagga agtgcaatat tcgcgttctg 107160 agtaactttc gcaatggggc aggtataaat gttctagcgc tgggttccac ccagaggcgc 107220 gcccacgtaa gtcaacacgc cattcctcca gtcatatgcc tggccaatct gcgacaggca 107280 tgggcaagat tgtcgcgtgg aataaatacc ggggcatggg ctacaaactc gtgaaagaaa 107340 actggcacac cggggtgagt ttctccatcc tcggactgcg taaaatattt tcttgacttt 107400 cttgacgaaa taatgtcttt taggcgagcc cttatttgcg gggcatgtct tctcttgcaa 107460 aagagaaaca tctgcaaact tttctgatgt ctatttgcac ctgcaaatgc ggacgtctta 107520 gtacatgcca tcggaactct gtctagggaa gtacaaatgt cttttcgaat gttatcggta 107580 agctgtcttc tcccgagttc cccgaatgaa aatatcatga aaacactgtc aaagccacac 107640 gagtccaaag attctacatc ttcggtgtta ttcgttttga catgcccttg gacggctacg 107700 tcttttgcgt ggtccggagt aacatgagaa tgcgtatcat gacattcgta cgatccggaa 107760 acacagtcaa tagacgaggc tccatataga acttctgtca cagaggggat ctcggtaccc 107820 atatcagaga ccacacgcca ccacagagaa aggtcttcaa tttattgttt atctcgcaat 107880 tttacatata ttttaacagc aacaagctcc gccccaaaat aaacaccggc ggaaaaaaca 107940 tactaatcta aattccagtc aatcggtgac aggcccttag attcgaagta ttgatttgct 108000 tcctcgaaat ggcgacagtt gaacggacgt cgcgtgcagg tagaaggatg gatgaactcc 108060 aactttaaat gatttttagg cacgcgggga ataaatcgtc tagcttcttg gccccaaagc 108120 atcaacaccg tagatgacaa cttttctagt agcgatgaga tcactccctt tgtaaatttg 108180 tcccagccga tggttgagtg cgatctagga aaaccttgtt ccaccgtcaa gtatttgttc 108240 aaaagcaata ctcccttcct ggcccaagat tctagacacc cgtgagtttc ctttggaata 108300 gatgggtaac agtcgcgtag agcttccaaa atgcggcgca agctgggcgg tatacggcac 108360 cccctaggga cactgaaagc taagccatgc gcgtgtcctt ccgtgggata cgggtcttgc 108420 ccaacgataa taacacgcac atcttgcgga ttgcagtatc ttgtccatgc aaaaatatct 108480 cctttaggag gaaagatttt gcggaatcta gaacagtagg agtactgtaa cagcgtctca 108540 ccgaaatctt cattttcaat tagaggtttc agaattgact cccatgatga tggtattgaa 108600 aactctatgg ccacgtcggt ccactccggt acgagcttcc tcgcggatgg tataaccaat 108660 tggacggaag tcatgctcgg aggggggaga gtacggcgtt ttttagcagc gttggggtcg 108720 gtatctcttt ggttgctttc agtaggagag ctaatgtcca gcggacgctt gaagggactt 108780 tttatgggct gctcgcatag tccgggtgat agtggttgat gttcgtttcc ggccatctga 108840 aatttatggt ggtcctttta tacaacgaat caacaagtcc acgagccaag acgttagcag 108900 ccgcaagccc ggtagcttcc agccggtctt gaagaagtct aatccccaag tacggattca 108960 cttttgcagc gtacccattc ttatagtaga aaacaacttc cgtgtttacg cacagaggtc 109020 tgtaaataat cacagtcaaa ttttcaaagt agtctcccga tggcaacggc ccgaaaattc 109080 gcgcaccgtt atctcgcgaa ttactatcac atggtgcggc cgcggcagaa acaggatcac 109140 gaaaaatgcc aggtatatcg acacttgaac atagcataag agatgctatt agaaaaaaac 109200 aagtcaacat tttaaaaatc attatcatat ggagacctag gtctccgttc acgatccgtg 109260 ttacgtcgac gagcagatgg aactctttgc gcccgacttc taaatggatc gtcgtcagaa 109320 tctgagtcgt ccgaatacaa atgtagtggt ctacaggaac cagtaggtac tctttgtggc 109380 ggacttttga atggatcgtc gtccgaatca gagtcgtccc aatataaata tgacggccta 109440 gatggagtac ttcggctctg tagtccggaa ggaccttcac ctgcgtcatc gtttcgcatg 109500 cggaggctcc gattctgcat ggaatcgagg tctaaaatac ctctgtctgc ggcgacgggg 109560 gattcgggtt cattctttat ccccccatga cgagtctgtg taccagtcgt attttgccct 109620 gcgccatcat aattagacga ggggtggtgg ggcgaaagct gtggagggga gcgtctagat 109680 ggcgagggga gggatgataa cctgaggtct agggccgtag gagatggcgc agaaaataaa 109740 gggggtatag aggacggacg tgcgggcggt ggactatgag cggggctatt ttctatttca 109800 tgccgcacga cccgtcgcac ccacgacatc tcatatacat ctcgcacttc tgctctactc 109860 gcaaggccat agttgccttc cccctcttct gtctccggta acataaacgt atcggatacg 109920 gtggtcggcc gctttttaac cattggatgt gcgagcccaa ctggcttgac gtccgtgctg 109980 tcatgagact cgcctttgac aggaaggcgg atcgacacca tcccggcgga atttttaaaa 110040 tatttcaaat ccaccgtgag tggtctggtc agcatgtcgg gctgtatcgt ctcaggaatg 110100 gccattccta ccctgtactc tagacccgat gcactctgta ccgtcggggt ttgttcgtac 110160 gccaaaaagc tatcatatcc gctagggtga ttcgtcgtaa actcacgtat ccatccattg 110220 atcctggtta gaaacgagta aaatacttca agcatctgtt cttcatcctg gaatggcaat 110280 tccactgcgc gtagtgcgga atttgctccg cgcgtcacca gatgacgcgc gtttgagatt 110340 tctggagctg aggcgattgc catactataa acgacacttt taaccctcag tagagtagaa 110400 tacagcgcct caaaatttct ccacgttagt tgacgagtta caaacgtttc aagcattatc 110460 gccctcaaaa cgactacaac gtcatctatg ggggatagcc ttccggtatg gtgtcttcga 110520 gttactggtc tttcctgttc caaaatagtc tggatggctt ggcgttctcc atcggtaata 110580 ggggtaccgg cctgccgcct ggtttgaagt aatctcctaa cgctttcaac tgttgtcgga 110640 aaataagcta caacagaaac caaaccatta atcctcgtac ctcaaaaaat cttacacgcg 110700 tcatcccacc ccacaaacca cttacgcctc atcaagaccc agaaatccat atagtgcgtt 110760 tcatcgatgt ccgccacgaa tgctatattg aaatctccgt tcattgtcat tcttgcgcgc 110820 gattctttac tctctccaga tcactaacgc gctcgccgtt gcactggaaa gaatatccgt 110880 gcagctccga cgcacgtcct tattagcccc cgcgcggata cacatgcgcg acgtaacggt 110940 atatccgagt tttcggatta gttcggtagc ggcacactca cccacttact aatcaaataa 111000 acacaccgta tgcgccaaaa taataaacat tcgtttattg atactttgtc agtctataaa 111060 tcaggtccgt cgatggatct ggatcggttc ctagacctgg accttaactg gtatctatcc 111120 ctgcccctgt gaggcccaat tcttctatcg tccaaaccta cattgcgtaa tatttcacgc 111180 gccctgcgga cacgaattaa aaatacgcgc gggtccgtcg ggcgttgcat ggggttgttg 111240 ttttctcctt catccgcgct caaatcagat tctgagctca atacgatagt ctctattggt 111300 tcctccctcc gttgggggtc gcggggttca acctcacgca catcagccag cggctgcggg 111360 ctctcggccc tcccgccctg tccccctcca tgccaaccct ccaccatttc cggcggtggg 111420 tcgtactcag agtaattgcc gtctgaatca tttgattcgg aactaagctg ctcatcttcg 111480 gctccaaatg gggcatcgtc tgcgtcttcc atcagcgctt cttgtactgc agcgtcgttc 111540 attgagtcat cgctatcgtt ttcacttgtg gacagtcggg catcctcact ggaggaggag 111600 tgccggtagt ggaccacaaa ttcgttatct acaggtgctc ggagacgcca gctctctgac 111660 tgtggtatag ccacactcac gttgacggga cgtacagagc ttaccagggg gtccccagca 111720 tctcggacag gcagcttaat tgtcacctcc cccacagagt tcttaaatgc ggcttccctg 111780 cgcgacttat agcgctccgg agctacaggt cgcaccctca caagcgtgtc ttttttgggc 111840 atctttctag ggttgacgta atacctcatc tcattttcct ggatatttgt gcgatgctcc 111900 aaatagccta tgtcagcttt gtgaccgcgt cgattagttc tactcttgaa cttacgacac 111960 cacctaatgg agtgtcgcag gaattgtagg aaatcctctg ccatcgactc tgggtcacgt 112020 actgggagag gaaatcgtag gaaaatttcg tatgcgcccc cgtacacctt ttccgttagg 112080 agctcgggct gatttgtacg tgtcatgata tcatatacta cctccttaag tcgtacaaaa 112140 gcctttagta tgtacagaat gtgctttatc gtcaatttgt gcagcaatag catctccatc 112200 gtggcggctt tcactaccat caggtattcg tctacaggag acatgcgacc cgactggtgt 112260 cgtctgatga cggtgcgttc gttgtccagc acatgctgaa ttgcactgtg gtcggatgca 112320 gagatcttac gcccctcttc cggattttca tgtctcgctc ggacctcccc tagcttcccc 112380 aactgtttta cgtcatgcat tctggtagga aagagcgcta gcaaaaagaa acacaaaaac 112440 aatagtatgg tggtgtctca catttgccca tgtccactca ggcacccact acccatccac 112500 atcactcgcc caagtttccc ttcccgcccg gctcttacgt tcttctatct ccagtatgcg 112560 ttccgttaac tggggcgtca actcgagttc taccgtcaaa tctttctgca cgcgactaag 112620 attttcctcg tcacccattc gcgcgaaatt tatcgccatg ccccgccggg ccgctgccat 112680 ttcaacgaac gggcccgatg gcgctgtggg aagagcaact cccgacgcgt cgcagcgatc 112740 taccgtctat tgcaacgagg tgctcgatgc gctgcttctt aatgacttgc ccatcgccgc 112800 tgcccgctct gtactacctt tctttcattt tttccgccac gcgaaagtga ccattgatgt 112860 actgcattgc gtcgcggaag cgcatgcagt gccgcgcgcg aggggtttcg aatagctcca 112920 cagccccgtc gtcggcaata aacccggggg ggtgttttgc gggggggggc tatatatgag 112980 cagccaagga tgcagggtgt gtgcactggt ggtccgcggt tttctccgac ccgtcccctc 113040 ccagtcccct gagtgctccc cgcccttcca atcccttgtg gtttcatgtc cgacccctac 113100 tattagatgc tggacaggtt ctggggttgc gagatacttg acggcccgac atcaaacgcc 113160 agcgtccgcc aacccccccc aagttcttcc acccgtggag agcaaacggt cagcgcgggc 113220 agccgtgaaa ctagttctac tagattttcc agtttagcct tttccggagc tgaaaaggtt 113280 caggtgggca ccggtgggct ccgactggac ctcgaagcgc gatcacagaa tcgtcacgca 113340 gttcgccccg tttgtaagtt tcgcggcagc gcgaggtgct ttgctcagta gtcatacagg 113400 tcacgcccgt ggttcttgca caataagcgc cacactggaa ttttcgattt ccagcaacgc 113460 tcactggcaa gaacggacac gaacgtgaag gccccggggg gggggggggg gtcttattcc 113520 gtataaccgc ctcactatgt ggccacggcc ggttaccgcg agttataata gtcaaggatt 113580 gaaagaagac agagcggttg ggtagctgac agttgtcagg ccgaaggtaa tacgcgctat 113640 cgatgtgaaa gctatccggg taacgacacc ttggcctaag gccgcaatta ggtgctactc 113700 aggttaagca cttagctaag cgcagtagca cctaactgtg cccgcactta tctttgtaga 113760 gtgtcgcgga agcaccgtgc tcccagtttc tggtattcgt aagcacgtgc tgtgagtctc 113820 agaggtttca aaaattctcg ttctggtaag ttgttcacgc gcaacccacg gcgggaaaat 113880 tttctgctct tgcaagggct ctagtgtagc cgcttccggg tatagtgggg gctagggctt 113940 tcccgccacg taaagctata taaatggtgg cagtgtatcc ttagggaaga acccagaggg 114000 agaactaggg gagaagtttc gcggcggcgg ttgcgcgcgg tgggaatgcc tggcaagtcg 114060 aagcctccat tgtccgccgc actggcgtta ctggtgttac tacttggagt cggggatgct 114120 cgcagtatac gcgcggcacc cttgaagtta ctggcggaga gcatcagaat actgcaccgt 114180 gtgcagaagg acgtaaggca actcattctc gttggaccat gctgacatgc ctgcacggtc 114240 tttgtaacta tgtacggcta ttcagtctat gttcacgttc ataactgtag gctctctcgt 114300 ttccttataa gggttcctgc gacggtagaa gagttccgaa catctttacg tccgacacgg 114360 tgagtaaaag ccagctcatt tgtcacatgt tctcaacggc aatgccctgg aggccggccg 114420 cgcgctagcc ccagattaaa aatgtagatt ttttgcttag gtctaccctg cccaataatc 114480 tgctcggcgg tttattaacg aatcttgctt ttcctgcagc gtctaaacga aactgaagag 114540 ttgtgccaat ccctttcggt cattttgaaa caccaacagt gtcacaaaaa actgcagggg 114600 ctctacgtca atttgtatta cgtgctgaat tctgtcagta atggcggtag ctctcgcaag 114660 gtaagataat ggcagcatcg cgcattctgt actttgaaga gactatctaa cgcgcagcac 114720 agtatctccg agacatcttt tgtctccgtg ctcacgcggt ccttattggt cgcatgacga 114780 gtctaacatt gtatctccta tttattacag gcaccgtgcc ctataacagt ggaggattcg 114840 tatttgatga agtcgttcct gaatgacctg gcgaacgccc tacagagacg ttacgtccgt 114900 cagagcaggc aatactagac aatctagtat tttgattgcg atttttatat cggcgcttgc 114960 aatagtaata atgctgccgg ccagcattac aagcttccgt ggatcttatg tatcaaaatg 115020 aacgaattaa atattcaagt gcattactta acacctcgtt ccgcctcctc ccgatattcg 115080 tacttgcccc cattctcgtc ccttttctaa tatcactcca tggccgcacg ggtagaatgt 115140 tcagcaaagc taaagtcaac ggggctagat catttccccg gtctttttct acaagtcgtc 115200 ggtggctgac aagctccgac tagcaaaaga atgagcacgc aaccagaagt aaattgtaca 115260 aaaagtttta ataagttaag ttaataacgg aaaccacggt taccaccaag ggtcagtgac 115320 agtgggatgc ggtagagggt agttagtcat gcgtctatgg cgttgacgcg accgcctatc 115380 ctctgaagag tctaatctgg gtacaagggt tctagtttcc cccctccctg aggagacgga 115440 tagccttggg cgcctggtgc gcgtgtgtcc ggtgcatctg ggtgactctg gcgttgctcc 115500 ccgcggagca ctccagcaac aacacattgg ggaccgattg cggggagtgt gataatggga 115560 atagtcgtca ccaagtagca atgcgagagg ggcgggattt ctggcacgca taagcgctag 115620 tccttccacg tgaagcgggt tccgacgcgc ccgcgcccct ggcgcatccg ggtaataatc 115680 ggagatgatg cggagaactt cctgtggaat tttgctggga tcggaccagg atgctgcgag 115740 agggagggcg ggaattaccg tgtccctccc ccacgcagcg acggccctaa aggaagcgga 115800 agtgcctccc acaatatcag cgcagggagt gcgcacgcgg tagtcccggc cacggtacac 115860 gcggtcccga atcaggaggc gctggcggcc gcgccgcttt ccacctccgg cgcgctcacg 115920 atcttctttc tcgttcttct cgtccccgtc ttcttcagat gagctggagt ctgaagaaga 115980 cgacgacgag gagcatgagg aagaggaaga cgacgaagaa gaatgcatag tggaactgga 116040 ctcggaaagg tccggacatg gcggcatcgc cccggcgccc acatggggct gggccatgta 116100 cggatacaag acggctgaag cttttccgat ttcggagtgg ctccacccgg catccatggc 116160 acgagcaacg tcgcgtagtc tcctgagagt tacgtgagtg aggaaggggt gcttaacggg 116220 aggacacttc tctctgtctc ctgtaccctc atcgtcgttg tcggtcttcc caacgctgag 116280 gggccatgag acagcgagtc gcctgtccat tactacgtga cctacattga gcccaccccg 116340 ttccaaccgt tcggccaccg gaccggtaaa cagttttaca aggtaagcgt gcgacggggg 116400 actagtccgg gcatagacaa cacccctccg cccggtaggt atgcgcggac ccgagcggga 116460 atcctcgtcc ccgggatccc tagcatctac gaccacgcat gcgcgcccag atgtactgag 116520 agcgcgctca agcatccatt ctaccgcccc ggcgtatcca aggtctgtcg tacagagaat 116580 ggccacgctg cggcccgggt ctttctcgtc gggagggata tagggatact ccccacgtgt 116640 ccacgattct ggccaacagg caccgcccgg catgcaggca cgtccgcaga gggccgcgta 116700 ggcgtacgcg cgttctaaaa attcgcccgg ggcacgttct gagacaagaa tgatgaggtc 116760 atagattttg tcagccggat gtcgcaacgt ccaggaaagc cgctcctcta agacgcagcg 116820 cccccctctg ttcacgggtg aaatcctctt gcaaaactcc cccagggcta ctgggtccct 116880 cgcaaaagca ggtagccaat ctgcgggtcc ggtcgcggaa tagcttcccg ccggaccgct 116940 gctcaacccg cgcaaatagt tcgcgagccg ctccaaagca ggacgcgcgc gatgggcggg 117000 cacgtatggc tcccctgcgg agagcgcaac gcccaagttt ttgccatggg gacggtaaac 117060 atccccttgg ttcgggatga aaccctccgg tgcgaacagg atggtagggc tgattggggt 117120 agaatgaaac agggcctcac ctatctcgga aatgtgaaag gacggggatt gtggttcttg 117180 cggttcttct cggggcggac atggtggacc ctcgggagtt atggggcatg gcgaaaggag 117240 gaggttgtct ctatctgttt ctggaaccgc tggaggtaat gaatctggta agccctggag 117300 gccacatgtt tttttagtcg cgttgccttc tgggatcggg tccgcgtgat cttcagatga 117360 ctttcttttc agacctttac gggtctcaaa gtcatcatct ggagggcggt cgggttcggg 117420 cccgtacggt gacacagata atggctcctg ttcatcgcac ggtggagctc tgggccaggg 117480 gttggcggga gattcttggg cagccgaagg ctctgctccg ttgccgccgc caggactccc 117540 gtagagtagg aggtgggccg cgcgatcggg agtgccggga ggtaggtcgt accggcaagt 117600 gctccgccgg ccgcctcgtc ttttgcgcct gtcatggtgg tgggtgtcat catctgcggg 117660 acaatcgtcc gtgacgtgct cgctgccggg cgcggaatca tctcctagca tggtagcgat 117720 catcctccaa ccagaggccg cgtaggcaat tgaaggccgc acgtcaccct cgtcggagca 117780 gccaagcacg cccacggcag cttccatggc ttctacaaga agagtgacat catcggtaga 117840 tggcagcggc agggacccta tgacgaggcg actccatagc gaagccgcgc agtagcgcat 117900 ggcgcgctcc cacgtaaaga ctgttttggg cgccctcgag agtgcttgat acagatccgg 117960 gcgacgcttg gcggggttta ttgtaactgg tgggcagtct atagcagtaa gcgccgccat 118020 gagatctgcg gcagcaacaa tgcaagttct agtatggcgc aatagcgccg aagaggaaag 118080 tttttccggg gttgccgcag gtggctcttt cgctgcggcc tccagctccc tcgtggcacg 118140 cgctattcgc ctggcgccaa cgagtacagg gtggtcccca gaagcagacg ccgccgtagg 118200 atccacggcc gctcctggaa atacaaacgg gacaaacgct ctcctaagag ccgccaacag 118260 gtaagttttc tgcgggtggt catagcggcg gcacacgcgt acgagctcgg taaggtgcgg 118320 cagagctaat gacacacggc catcacgcat ggcgtgcgct acgtgcggaa ggcacgtcgg 118380 caccgcagaa cgagacaatc ctccctcgga agaacccgga ccgcggagag cgcacagttc 118440 gcagagccgt ttgtcacgtg ggctcagctt ggggccacca tacccatacg aaacgcgcga 118500 caggggctgg accatgaact cctccacaag gcgctctaac tgttccactg gcatcccgta 118560 ctcttcgaga tacacggaag ctgatttcgg attggcatgg aattcggccg cggcctcccg 118620 aacctgcggg tcatcgacca aagactgtct atagccactt ccatgatata cttgtcctct 118680 actgggtggg gatgggataa tagcttctgg aacaaaaacg cgagcctcgg aactatggag 118740 gtcgacggcc aacgctcgtg agagtacatt cagggtaatg ccgcggccta ggtctgggag 118800 ctccgtaggc gcggttactg actgaaccga cccgtctgta ccgtccgttt cgacccactc 118860 cctcaaaact cgccagagtg gctctagcgc gacatcggga cattctccag gtagcactaa 118920 ttgggcagag tcccggtcgg ggctttcggt ggatttttca cttcctgcgc tttccagcct 118980 tcgggcgaga cgtcccctcc tccctgacag cgagaatgag gaagaggagg aagaggagga 119040 agaggtaagg tggctcgggc ccatcttctt cgaaaattcc ctcttccctc gctcggggag 119100 acggtctttg ctggtcctct gcggcgaagg gacggggcgc cggttgctca aagatcgcgc 119160 cacggcgcgt cgcgaacgag atctggccac tctctctgac ttcctcacca cttcttgacg 119220 cctcacagcg gttgttttct ctactgcagg taatggacac gggcattcaa cgtgctgctg 119280 ctccatggga gtttcgcagg gatgcgcgag cgagtcgatg accgcataaa ctccgggctg 119340 atcggtatcc acgttaatat ctagtgccac gacatcactg gtagcgttcg gacacggttc 119400 tatagagttt atgttttcgg gatccatgtc gtttaacatc gctataaggt cgcggagaga 119460 catttctcgc ccgtccacgt cttgggccgc attctcagcg atgacagagt gaaagagctc 119520 gtcctcgctg gaaaaaagag gtggcgtgct gtacgaaaag ctatcagtag tggtctcaca 119580 ggtaggtgcg tttggagggt tcgggatggg agaacccaaa gaatcgtagc gcccactctt 119640 atcggcgcgc aaaaaggtaa atagatctga gggcgggcca gttgagaatc ccgactcatc 119700 aacaattgga gcggccaaat tactcggcgt cgaggaatca gaggacatga tagaatgcta 119760 gtggaaggac tagcgatttc cagaatcctg cagaacaaga cccgagtgac aaggttacgt 119820 aagttttgtg cagaagttgg aagaaacgtg aagctttctg gtggggagta gtaacagaaa 119880 aataaagatg cgcgactctc gaaacctccc gtttctcgcg ttggcctgtt tatttccgtc 119940 cccgcaatgc agagcacaat aaagctccgc aaccataggc acaattttgg aacagcaata 120000 catgctaaag aagtggatta tcgttttgtg cgcttcatgt tcatccataa cagcagccca 120060 tactcttgac tgtatggggg aattattcga agcccacagt catatttttg cacgataccc 120120 catgcaaaag gatatttcgt ggtcccctca aataatgaca gcccacctaa tcccacccca 120180 aaatttataa cagaatattg gtttcatgac ttacgttttg cgaagaggtc ctttccacgc 120240 tgggtaggtt tcagcaaagg tgttgtgaag aaagaacttt ggagagtcaa cccctcggtc 120300 ttgtgcagtt ggtttgggta tggcatttgt attgaggcat gatataattc agatccaatg 120360 gcgcccatgc ggcctgcata tcgttagcga gcgtatttcc agttccggtg tgccatagcc 120420 aatgcatgcc atgcgcccag cataccatta ccgtaccagg aacttccggc attttttatg 120480 agccaacata ataaacaaac ctgagcctac tgtagaacag atgacgaaga taacaaaaca 120540 atacattact tgtgtccaca ggtacgtgca attcggtgcc ggggtgtgtg cctactctag 120600 aaaggtcacg cgtgtgtttt gttggcattg atattacccg agaaacacgc tcgcttgtac 120660 gttattggcc acaccgggaa gcagtgaagt ttattttgaa tgccaacgaa agcacatggg 120720 tcacgcttcc tgggagtgcc aaggaagttg tgacagaaaa aagatcccca tatgggagag 120780 ttgacatgtg taaatatcac cgtgagcact tgtgttactt gtgtgttcta atctctagca 120840 attttccacg aaagattatt atcttctagc cacccctcta acccagccta aataaaaaat 120900 tcagacaacg caaaagcttg gttccatgtt ccacgcgagt agttcgcggg aacacataat 120960 tactttattg agacatttgc cgctcgggat gcacgaatcg caaattttga atctcgggat 121020 gcgttctgta tttgcagggc acttttcttc ttttgagaga tatggcgaga aggtccatgc 121080 tcgggaatat agttcgcaat ctggtttgcg atttacaaac gtccctgtaa ttttcttacg 121140 cggatctgga agtaatcgca ggagcctctc tgcaggagac ttgccgattc gccggtgaat 121200 cgcaaataca cttccagata tatatgtcgg ggggtcacgg cactgtctct acaggtttct 121260 tttaggaaac gcacctatgt cgggttgccc gtgggactaa aaccagttac ttgcgcgtgg 121320 aagcagccgc aggcttagca gatgcgctcg aaacaaagca cgagttgcaa tagccggtat 121380 aatatcaagg tacgggctat atacatgcgc gtaatacatc catactggat ctacccagta 121440 atcgtgttaa ctggcggtgt tacaacgcag tcgtagcagt aatatgaaag tatgcaatat 121500 gtatgcaata agcaagggca acgaagccga taacctgcac gtcggtgggc ccaaacaact 121560 cagcggccct attaaagagc aaataaagta gtgagcccgg cacatgccga acagctcaag 121620 taaaaacaaa aattcataaa gtgcaaaccc gcctatggcg gttcagtgtt aactagctct 121680 tcacgacaat cgactttgtt gggtccttat tttctgggtc aggtaaactc gaacatgagc 121740 tttcgtagag tatttttaac ccgcgatgtc ttggagagta tcggtcacgc agcctccgga 121800 tgagttcatc ccgccgaata tcacttcccg atcacattca gggtcggggg tcgagggggg 121860 tgctcgaccc gggtcgtgtg tatcgtgagg acaagcctct ccgatcggcg acccatcccc 121920 atctgggaca gtgcatggct ttaaacggag cctgcgtcgg cgtggtctgg aggcatcggc 121980 ggggggattt tcgggttgct catgtgagaa gacaatgacc cctcccattg tgtccccagt 122040 atgaaatctt ctcccctctt cctggggtaa tccgagcagg acccgatggt cccgctatat 122100 gcggggacag cgacccggat cgttctttta tgcagtgccc gaagaggcaa gtcacagctc 122160 attggctgga agggggatgc aggaccctcg gtgcgaacgt gacgtaggtg ggtgccaccc 122220 acatcatgta aattaggtca cggggtaggg ttctggatcc gtgattggtt atgaggctcc 122280 taaagcaaac attcgcactc cagtatttaa taaattaggt ttcacctaat atattaaata 122340 ccgtcgtgcg aatgtttgct ttaggagcct cataaccaat cacggatcca gaaccctacc 122400 ccgtgaccta atttacatga tgtgggtggc acccacctac gtcacgttcg caccgagggt 122460 cctgcatttt cctaaaatgg caaagcggga ctggggtccg tgggtaaatt ttctaatttt 122520 ttcccacggt ctgtcgcaag agcgtattct ccaagataga atgctgttag attttcccga 122580 attttgtcga ggtcacgcgt tttgtaatgg aatatggcgc gagaatattg agtttaaatt 122640 ttgtccgcgc gccaaacttg aagtgatatt aggacatagt caaccaaccg acatacgttg 122700 aaccatttgc gggcagcgct gagggaagac gagatgtatg gacaacacaa cgaccggaga 122760 agagggcgta aagaacatca cggtcttgct ctacggtggg ggtaacaaca atttaataaa 122820 taaaaagttt ctttaatata agagcggtat agcagattta ataaaatacc ttttttgaaa 122880 aaatattgac ctgtctcgcg ttgtagattc ttcgcatccg cgttccgtca ttattccaag 122940 attttgcgtt tcattccaat tcaatcaatc ctagaaggca aaagaaaaca taacacgcaa 123000 atataaggat cggtattttg acattttaaa tgtgttttta aggaaaaggg tagaactttg 123060 gggaggagtt ggtacgtggt agtcacaatt tgacagacag gtagacagac aacgaattac 123120 aagcggccta gggtaataac gctgagccca tgatgtgtcc gtgcatatga gacgactaat 123180 aaggtagtca cgtaaacccc cgtcaatcac acgcgaaaga aagaaagaaa ggaaaaggcc 123240 tcaaagcaaa ttttgtagct taaaaaagag ggggctctaa agaagaagca acatcgtctc 123300 gggctgtgtt tccgacgttg gggtgcatta tgcgatttta ctaccagtgt ttggtgtggt 123360 gtggtaaggg gaaatgagac gagaattttt cgcgtgcgct cgaggacaga gctacgccca 123420 accgtgagca aattgcgcgg cgcttccttg ttagcgtggc gtcacgtata aatgcacaga 123480 agcttcgtca gtaacgaagc gcctctgcca gagttattaa cattaggact cgagagagtc 123540 tcgagaagag acttctcaaa gagagtgccg ctttgatctc cagatcacct cacagcccat 123600 tgagactttt cctttttgac acgtgagtag ggcgatattt tgtgcttatc cgagaacggc 123660 cgcaaaccac ggcctactcg aaccgcgcat tccctgcgga aagacaacac gagtaaataa 123720 gacccagtgc gcaagatatg agccacagtc ctttgtcgag tgatccctct cccttgccag 123780 aagagaccta tccgtcgccc cgcggaaagt caccagagca gcttccctgg gatcccgaag 123840 agctctccca gaagtttttc ttttcggacg tatcggagga cgaagaaccg gcacgcggga 123900 ggagctggag cgacccggag tcggaggaag agcagcctgg gtgccgggga gtggacttgg 123960 gcgaggagga cacgggacac agctccaccg agtcagagcc cacgcaatct gacttagact 124020 ttattgacga cagctctccg gcgccgccgc catttgctat cccccgcgtc cgtgcgttat 124080 tgcggtgcgc ggcaccccgc aaagacccac ggaaggcttc ggccgccagg gcgggtaggc 124140 gcactcttaa aagacggagg ttgtcatttt cttcttcctc tgacgaggaa tccgaggaga 124200 gaagtaaaaa agaagaagcg gcctcgaccc ctgcacggcg acgcaaggcc gaggcctcga 124260 cgagcagata gaggagacgc ggggcagaac ctccccctcc ctcccatccc cctactctgg 124320 acatttattg cccgctcgat ccattctcat ccagaacttc tttcccgctc ggccttcacg 124380 cagaagcgga cgcgcgcccc tttgcgaccg ccggacatcc cgccgccccc ccccttcacg 124440 cccggcgcaa tccgtagccg tccaactcgg cctagcacaa ccgcagtaga ccgcccggac 124500 cgctctcctc tagacacatc cctaaatgga aaacatgctc gacgggtgct acccgctggc 124560 gctgatggac agcgatcacg ttactgcgca cgcggtacct cgtggcgagc ggaggcggca 124620 aggtgccgtt gccgcctcgt cggagtcggc cgactcggta gacccgtgca ttcggatcgc 124680 ctcgcggctc tggcgcgagt tagtcgagat atcgtccgaa ctcaaggacg gttacggaga 124740 gttcacgtca gcgagagacc gccgcaacgc gctgattgct gccaacgaac ggctacgttc 124800 ggcttttctg ggggccagcc gggcgacgcg cggcctaggt ttgaggccgc gttgggcgtc 124860 gacggagagc gtcgccaact cccccactga cccgaataac ggcaacgggt tgggagaatt 124920 agaggaggca atggaaggga tcgagggcga tttctggctc gactctctgg acggtgaccg 124980 cttcgaggac gagagccgta ccatgcagag cgagaatatg cgtttcgtga tcgagaaaga 125040 actgttatcc tggctgtccc gacacctgcc ggccgacctc gcgtccgccg agcgagagac 125100 ctcccggtct ctcctggcgg ccgggcactg gtgctgcctg tggcaccctc ggccgtgccg 125160 cgaagcgtgt ttgtacgact cgatttacgt gcagagtctt ttccgcgtcg ggacggggag 125220 agtcccgcaa tcggagatgc gccgtcgcga atacctggcc gccttgcgcg ccggcgcggc 125280 tgccgccaac tctcccgaag tgagcgcctc gatctttgcg agggacgctg gaatcgcgct 125340 ggcgctggcg cggcgccgtt gacgggagaa tgacgccctc tagcggcttc cttacctccg 125400 cgtccctgac aacctcgcgg gtttttacac tgtcctccgt ccactctccc cccccaccca 125460 ctccgcggca gcgaaacaca accccccccc ccccccagaa acgagcgaca cgcgagcgct 125520 gcgaaataaa taaagtaata ttattgtgtg tttttcacgt tgttgcaatc gagaggccgt 125580 ttgtctgtct gtgtctgtgc ggagctaggc tttcccgggc ggccccgttc caccgttcgg 125640 ttaggccggc ggcgacggga catagagaaa gagagagcgc gcgccctggc ggcgagaggg 125700 tgttgcgggg gtaaatggga ccctgagctc accattttgg cgggggattg cacgggtaac 125760 aaaaagctct ctcgcacata atcatttccc ttaaacagtg gctgtaaaag ctttcttcga 125820 ctgggacgcg cacgtccgga gacatgatct tatcggtagc tacacagttc atgaggtgag 125880 ccacgaacgc gcggatcgag ttttgggaac cttcggggag gtcttccggg agggtgaagt 125940 ttgacagagg caacgctatc accaggaggc tccgcaccat ctccatgcct atccttatcg 126000 ccgcgagtcc ggcggccggc gcgctgctct ggttattcca gtgcgcggac cgcgagtgcg 126060 cccctccccg ggctctgata tagagcaccg gcagctcgac ggcggcggag aaaaaagaaa 126120 gaatgtccgg cccaatgact ggaactttgg gcacgtctct tatttcccac gcggcggccc 126180 ggggaatctg cttgccccag accttgcttt ccaactcccc gttcggcccc ccaactaact 126240 ccgacagcgc ggtccacagt cccaccgccg ctgcgacggc gcgcttagcc gcgggcgcta 126300 ttcgcgggtc gtgcgccgtg atatcttcgg cgacctgcag actgcccaac ctttccttcc 126360 cttcaaaata cgcgcgggcg gcctgtacga tcaccgcggc cagatcgggc caaaagaaaa 126420 tatcgcaact ctgcgacgcc cgccagaatc ttcctccggg caggtccgtg cccctaaagg 126480 ccgccgagaa agctaagtcc aaatgtgacg tcggaggtct cgacatggtc gccaaccctc 126540 caaatgctac ccgccggccc acgcaacgcg ggcttttata aagatggcgc gcgagacaat 126600 aacacttact catccgcgta cgcgtttatt attgtcaata tttgtgtggt tattattact 126660 gctaccgccc ttgtttctgc aaggccctcg ccgcggccca ggccactatt ccggcagcgg 126720 ccgccgacgc agcgagcgtc gccgctaacg tcggcgccgc ggggagcggg gtttcttcga 126780 cttaaataga ctcccgagaa aaaattttgg ctgccgttcg ccatcatccg agtcggaaac 126840 acagtatgcg gccgagttag gttttacttt taaaaacttt accgtgctat acggccaggg 126900 cgttctcagg ctcgaggggg caagagttgt ccagactgat gggtgactca gagacagcgt 126960 tgtcttgtct ccgtttacca aaaatatttc cactcctctc tcaaaatttt tacctccggt 127020 ttcggtaatt aggaaagttt ttggcgcagg gaggtttaaa gctgccatgc atatgtcagc 127080 ggtacccagc acccacaaat ggaactcttt tgcggcatac gcgccagatg acaaatggta 127140 aaaccctgcg tccaagccgc tccactcggg acttactcca ggcgggtcgc ccccctcacc 127200 gaaccgaatc acgggtctgc acatcctggg aagggaaaac agctccccgg aaacttcgta 127260 cagagatgcc gggcgcacga ttaccgataa tgtactcgga cgatcgtaac tcgccatagt 127320 tttcactgcg tgaaccaatt ctttccatcc agaatccgag agctcaaatc tagaattagg 127380 tagtttgtag tgcgaatcga ccgcagaaac tatagtcact tttacaggcg ccatcgccgc 127440 tcagactcca ccccgctatg atgtcaggaa tataacgctc ttattctagc agagtcaggc 127500 caatatatac agcttagaga agatgcggtt tcggcgcatc tgttcacgct ctagggcaga 127560 aaaacgaaga agaacaaccg agaatccgct tacctcaaaa cgcgtttgcg tattggatag 127620 tttctcacgg acaatgtcat tgcgccccta tgcagaaatt ttgccgaccg cggaaggcgt 127680 cgagcgcctc gccgaacttg ttagtgtgac aatgacagaa cgcgcggaac ctgtgacaga 127740 gaatacagct gtaaacagta ttcccccggc taacgagaac gggcagaact ttgcatctgc 127800 aggcgatggg gcctcggcta ctgaaaaagt tgacggctcg catacagact tcgatgaagc 127860 atcgagcgac tacgccgacc ctgtcccgct cgcgcaaact agattgaagc attcggatga 127920 atttcttcag cacttccgag ttttagacga tttggtggag ggggcttacg ggtttatctg 127980 cgacgtccgt cgctacaccg aggaagagca acgtcgaaga ggggttaaca gtactagcca 128040 ggggaaatca aaatgtaagc gcctgatagc taaatatgtg aaaaatggaa caagggcggc 128100 ctctcagctg gaaaatgaaa ttttggttct cgggcgccta aatcacgaga atgttctcaa 128160 aatccaggaa atccttcggt acccggataa tacgtacatg ttaacgcaga ggtatcagtt 128220 cgacttgtac agctacatgt acgatgaagc gttcgactgg aaagacagtc caatgcttaa 128280 acagactaga cgcatcatga agcagctcat gtcagcggtc tcgtatatcc attcaaagaa 128340 actgattcac agggacatca aactcgaaaa tattttctta aattgcgacg gcacgacagt 128400 gctgggcgac tttggaactg tcacgccttt tgaaaatgag cgggagccct tcgaatatgg 128460 atgggtgggg accgtggcta ctaactctcc cgagatactc gccagggatt cgtactgtga 128520 aattacagac atttggagct gcggagtagt attgctggaa atggtaagcc atgaattttg 128580 cccgatcggc gatggcgggg gaaatccgca ccagcaattg ctgaaagtta tcgactctct 128640 ctcagtttgt gatgaagagt tcccagaccc cccgtgtaat ctgtacaatt atttgcatta 128700 tgcgagcatc gatcgcgccg ggcatacggt cccgtcgctc atacggaacc tccaccttcc 128760 ggcggatgtg gaataccctc tagttaaaat gcttactttt gactggcgtt tgagacccag 128820 cgcggccgaa gtattggcaa tgccactgtt ttcggctgaa gaggaacgga ccataacaat 128880 tattcatgga aaacataaac ccatccgacc cgaaatccgt gcgcgggtgc cacggtccat 128940 gagtgaaggt taataataaa ggacggagat agagaactga agcgtcagat ttttttaaaa 129000 aaataaatga tcgagaactt atgatttgtc tttcttgaat gaccttgccc catcgattaa 129060 cgaaaagacc tttcgcgcgt cgattctgct cggtctttgt gatacagtat agtgagacta 129120 aactcgaccg atataacaag gcaatgttac tctttagacc ggactcaacc atgcggcata 129180 gcggaggcga cgcaaatcac agagggataa ggccgaggcg gaaatctatt ggagcgttta 129240 gcgcgcgcga aaagactgga aaacgaaatg cgctgacgga aagcagctcc tcccccgccg 129300 acatgctaga tccgttttcc acggataagg aatttggcgg taagtggacg gtagacggac 129360 ctgccgacat tactgccgag gtcctttctc aggcatggga cgttctccaa ttagtgaagc 129420 atgaagatac ggaggaggag agagtgactt atgagtccaa accgaccccg atacagccgt 129480 tcaatgcctg gccggacggg ccgagttgga acgcgcagga ttttactcga gcgccaatag 129540 tttatccctc tgcggaggta ttggacgcag aggcgttgaa agtaggggca ttcgttagcc 129600 gagttttaca atgtgtaccg ttcacgcgat caaagaaaag cgttacggtg cgggatgcgc 129660 agtcgttttt gggggactcg ttctggagaa taatgcagaa cgtttacacg gttgtcttac 129720 gacagcacat aactcgactc aggcaccctt ccagcaaaag cattgttaac tgcaacgacc 129780 ctctgtggta cgcctacgcg aatcaatttc actggagagg aatgcgcgtg ccgtcgctta 129840 aattagcctc tcccccggag gagaatattc aacacggtcc aatggccgcc gtttttagaa 129900 acgcgggggc tggtctgttc ctgtggcctg ccatgcgcgc agcctttgaa gagcgcgaca 129960 agcgactgtt aagagcatgc ctgtcttcac tcgatatcat ggacgcagcc gtccttgcgt 130020 cttttccatt ttactggcgc ggcgtccaag acacctcgcg cttcgagcct gcgctgggct 130080 gtttgtcaga gtactttgca ctagtggtat tactggccga gacggtctta gcgaccatgt 130140 tcgaccacgt actggtattc atgagggcgc tggcagacgg caatttcgat gactatgacg 130200 aaactaggta tatagacccc gttaaaaacg agtacctgaa cggagccgag gggactctgt 130260 tacgaggcat agtggcctcc aacaccgctc tggcggtggt ttgcgcaaac acctattcga 130320 cgataagaaa actcccgtcc gtggcaacta gcgcgtgcaa tgttgcctac aggaccgaaa 130380 cgctgaaagc gaggcgccct ggcatgagcg acatataccg gatattacaa aaagagtttt 130440 tcttttacat tgcgtggctc cagagggttg caacacacgc aaatttctgt ttaaacattc 130500 tgaagagaag cgtggatacg ggggccccgc catttttgtt cagggccagc tcggagaagc 130560 ggctgcagca gttaaataaa atgctctgcc cccttctcgt gccgattcaa tatgaagact 130620 tttcgaaggc cctggggtct gagctcaaga gggaaaagtt agagacattc gttaaagcta 130680 tttccagcga cagggacccg agggggtccc taagatttct catttcggac catgcaaggg 130740 aaattattgc agacggagta cggtttaagc cggtgataga cgagccggtt cgggcttcag 130800 ttgcgctgag taccactgcc gctgggaaag tgaaagcgcg acgcttaacc tcagttcgcg 130860 cgcccgtacc gggctcaggc gccgtttccg cgcgccggaa atcggaaata tgataaaaat 130920 gcttggcatt tgcgggcgaa gaggcgtgat ctgaagggct ccataatgac gtaactgagc 130980 tacgcatccc tataaagtgt acccgctgac cgctagccca tacggtgtta caggagggga 131040 gagcgacaac ttcagctcga agtctgaaga gacatcatga gcggcttcag taacatagga 131100 tcgattgcca ccgtttccct agtctgctcg cttttgtgcg cgtctgtatt aggggcgccg 131160 gtactggacg ggctcgagtc gagccctttc ccgttcggga gcaaaattct agcccaggcg 131220 tgcaaccgca ccacgattga ggtgacgggc ccgtggagcg actactctgg tcgcaccgaa 131280 ggagtgtcag tcgaggtgaa atggttctac gggaatagta atcccgaaag cttcgtgttc 131340 ggggtggata gcgaaacggg cagtggaaac gaggacctgt ctacgtgctg ggctctaatc 131400 cataatctga acgcgtctgg gtgcagggtg tctgacgccg ggatacctga tttcgacaag 131460 cactgcgaaa aagtgcagag aagactgcgc tccggggtgg aacttggtag ttacgtgtct 131520 ggcaatggat ccctggtgct gtacccaggg atgtacgatg ccggcatcta cgcctaccag 131580 ctctcagtgg gtgggaaggg atataccggg tccgtttatc tagacgtcgg accaaacccc 131640 ggatgccacg accagtatgg gtacacctat tacagcctgg ccgacgaggc gtcagactta 131700 tcatcttatg acgtagcctc gcccgaactc gacggtccta tggaggaaga ttattccaat 131760 tgtctagaca tgcccccgct acgcccatgg acaaccgttt gttcgcatga cgtcgaggag 131820 caggaaaacg ccacggacga gctttaccta tgggacgagg aatgcgccgg cccgctggac 131880 gagtacgtcg acgaaaggtc cgagacgatg cccaggatgg ttgtcctttc accgccctct 131940 acgctccggc agtagccacc cgagagtttt ttttgtgagc gcccacgcaa catacctaac 132000 tgcttcattt ctgatcaatt attgcgtatt gaataaataa acagtacaaa agcatcaggt 132060 gtggtttgcg tgtctgtgct aaaccatggc gtgtgcgggt gaaaccgtaa attacgtgat 132120 aataaatagc ataggagttg gcgtgcagcg tatttcgccg agagatgggg acaatgttag 132180 tgttgcacct tttcctactt gcagtagcgg acgcggcgtt gccgaccggc agattctgcc 132240 gagtttggaa ggtgcctccg ggaggaacca tccaagagaa cctggcggtg ctcgcggaat 132300 cgccggtcac gggacacgcg acatatccgc cgcctgaagg cgccgtcagc tttcagattt 132360 ttgcggacac ccctactttg cgcattcgct acggcgctac ggaggacgaa cttgcactgg 132420 agcgcgggac gtccgcctca gacgcggaca acgtgacatt ttcgctgtca tatcgtccgc 132480 gcccagaaat tcacggagca tacttcacca taggggtatt cgctactggc cagagcacgg 132540 aaagcagcta ttcggtcatc agtcgggtct tagttaacgc ctctctggaa cggtccgtgc 132600 gcctggaaac gccgtgcgat gaaaattttt tgcagaacga gcctacacgg ggctcgaagc 132660 gttggttagg ccccccgtcg ccttatgtgc gagataacga tgtcgccgtg ttgacaaaag 132720 cgcagtacat tggggagtgc tactccaact cggcggccca gacggggctc acgtctctca 132780 acatgacctt tttctattcg cctaaaagaa tagtaaacgt cacgtggaca accggcggcc 132840 cctccccctc gcgcataacg gtatactcgt cgcgggagaa cgggcagccc gtgttgaggg 132900 acgtttctga cgggttcttg gttaagtata ctcccgacat tgacggccgg gccatgataa 132960 acgttattgc caattattcg ccggcggact ccggcagcgt cctcgcgttt acggccttta 133020 gggaaggaaa actcccatcc gtgattcaac tgcaccggat agatatctcc gggactgagc 133080 cgccggggac tgaaacgacc ttcgactgtc aaaaaatgat agaaaccccg taccgagcgc 133140 tcgggagcaa tgttcccagg gacgactcta tccgtccggg ggccactctg cctccgttcg 133200 ataccgcagc acctgatttc gatacaggta cttccccgcc ccccactacc gtgccagagc 133260 cagccattac tacactcata ccgcgcagca ctagcgatat gggattcttc tccacggcac 133320 gtgctaccgg atcagaaact ctttcggtac ccgtccagga aacggataga actctttcga 133380 caactcctct tacccttcca ctgactcccg gtgagtcaga aaatacactg tttcctacgg 133440 ccgcgccggg gatttctacc gagaccccga gcgcggcaca tgaaactaca cagacccaga 133500 gtgcagaaac ggtggtcttt actcagagtc cgagtaccga gtcggaaacc gcgcggtccc 133560 agagtcagga accgtggtat tttactcaga gtccgagtac tgaacaggcg gctcttactc 133620 agacgcagat cgcagaaacg gaggtgttgt ttactcagac tccgagtgct gaacagatga 133680 cttttactca gactccgggt gcagaaaccg aggcacctgc ccagaccccg agcacgatat 133740 ccgagatatt tactcagtct cgtagcacgc cccccgaaac cgctcgcgct ccgagcgcgg 133800 cgccggaggt ttttacacag agttcgagta cggtaacgga ggtgtttact cagaccccga 133860 gcacggtacc gaaaactact ctgagttcga gtactgaacc ggcgattttt actcggactc 133920 agagcgcggg aactgaggcc tttactcaga cttcgagtgc cgagccggac actatgcgaa 133980 ctcagagtac tgaaacacac tttttcactc aggccccgag tacggtaccg aaagctactc 134040 agactccgag tacagagccg gaggtgttga ctcagagtcc gagtaccgaa cctgtgcctt 134100 tcacccggac tctggacgca gagccggaaa ttactcagac cccgagcgcg gcgccggagg 134160 tttatactcg gagttcgagt acgatgccag aaactgcaca gagcacaccc ctggcctcgc 134220 aaaaccctac cagttcggga accgggacgc ataatactga accgaggact tatccagtgc 134280 aaacgacacc acatacccag aaactctaca cagaaaataa gactttatcg tttcctactg 134340 ttgtttcaga attccatgag atgtcgacgg cagagtcgca gacgccccta ttggacgtca 134400 aaattgtaga ggtgaagttt tcaaacgatg gcgaagtaac ggcgacttgc gtttccaccg 134460 tcaaatctcc ctatagggta gaaactaatt ggaaagtaga cctcgtagat gtaatggatg 134520 aaatttctgg gaacagtccc gccggggttt ttaacagtaa tgagaaatgg cagaaacagc 134580 tgtactacag agtaaccgat ggaagaacat cggtccagct aatgtgcctg tcgtgcacga 134640 gccattctcc ggaaccttac tgtcttttcg acacgtctct tatagcgagg gaaaaagata 134700 tcgcgccaga gttatacttt acctctgatc cgcaaacggc atactgcaca ataactctgc 134760 cgtccggcgt tgttccgaga ttcgaatgga gccttaataa tgtttcactg ccggaatatt 134820 tgacggccac gaccgttgtt tcgcataccg ctggccaaag tacagtgtgg aagagcagcg 134880 cgagagcagg cgaggcgtgg atttctggcc ggggaggcaa tatatacgaa tgcaccgtcc 134940 tcatctcaga cggcactcgc gttactacgc gaaaggagag gtgcttaacg aacacatgga 135000 ttgcggtgga aaacggtgct gctcaggcgc agctgtattc actcttttct ggacttgtgt 135060 caggattatg cgggagcata tctgctttgt acgcaacgct atggaccgcc atttattttt 135120 gaggaatgct ttttggacta tcgtactgct ttcttccttc gctagccaga gcaccgccgc 135180 cgtcacgtac gactacattt taggccgtcg cgcgctcgac gcgctaacca taccggcggt 135240 tggcccgtat aacagatacc tcactagggt atcaagaggc tgcgacgttg tcgagctcaa 135300 cccgatttct aacgtggacg acatgatatc ggcggccaaa gaaaaagaga aggggggccc 135360 tttcgaggcc tccgtagtct ggttctacgt gattaagggc gacgacggcg aggacaagta 135420 ctgtccaatc tatagaaaag agtacaggga atgtggcgac gtacaactgc tatctgaatg 135480 cgccgttcaa tctgcacaga tgtgggcatt ggactatgtt tctagcaccc ttgtatcgcg 135540 aaatggcgcg ggactgacta tattctcccc caatgctgcg ctctctggcc aatacttgct 135600 gaccctgaaa atcgggagat ttgcgcaaac agctctcgta actctagaag ttaacgatcg 135660 ctgtttaaag atcgggtcgc ggcttaactt tttaccgtcg aaatgctgga caacagaaca 135720 gtatcagact ggatttcaag gcgaacacct ttatccgatc gcagacacca atacacgaca 135780 cgcggacgac gtatatcgga gatacgaaga tattctgcag cgctggaata atttgctgag 135840 gaaaaagaat cctagcgcgc cagaccctcg tccagatagc gtcccgcaag aaattcccgc 135900 tgtaaccaag aaagcggaag ggcgcacccc ggacgcagaa agcagcgaaa agaaggcccc 135960 tccagaagac tcggaggacg acatgcaggc agaggcttct ggagaaaatc ctgccgccct 136020 ccccgaagac gacgaagtcc ccgaggacac cgagcacgat gatccaaact cggatcctga 136080 ctattacaat gatatgcccg ccgtgatccc ggtggaggag actactaaaa gttctaatgc 136140 cgtctccatg cccatattcg cggcgttcgt agcctgcgcg gtcgcgctcg tggggctact 136200 ggtttggagc atcgtaaaat gcgcgcgtag ctaatcgagc ctagaatagg tggtttcttc 136260 ctacatgcca cgcctcacgc tcataatata aatcacatgg aatagcatac caatgcctat 136320 tcattgggac gttcgaaaag catggcatcg ctacttggaa ctctggctct ccttgccgcg 136380 acgctcgcac ccttcggcgc gatgggaatc gtgatcactg gaaatcacgt ctccgccagg 136440 attgacgacg atcacatcgt gatcgtcgcg cctcgccccg aagctacaat tcaactgcag 136500 ctatttttca tgcctggcca gagaccccac aaaccctact caggaaccgt ccgcgtcgcg 136560 tttcggtctg atataacaaa ccagtgctgc caggaactta gcgaggagcg ctttgaaaat 136620 tgcactcatc gatcgtcttc tgtttttgtc ggctgtaaag tgaccgagta cacgttctcc 136680 gcctcgaaca gactaaccgg acctccacac ccgtttaagc tcactatacg aaatcctcgt 136740 ccgaacgaca gcgggatgtt ttacgtaatt gttcggctag acgacaccaa agaacccatt 136800 gacgtcttcg cgatccaact atcggtgtat caattcgcga acaccgccgc gactcgcgga 136860 ctctattcca aggattcgtg tcgcaccttc ggatttccta ccgtccaact tgaggcctat 136920 ctcaggaccg aggaaagttg gcgcaactgg caagcgtacg ttgccacgga ggccccgacg 136980 accagcgccg aggcgacaac cccgacgccc gtcactgcaa ccagcgcctc cgaacttgaa 137040 gcggaacact ttacctttcc ctggctagaa aatggcgtgg atcattacga accgacaccc 137100 gcaaacgaaa attcaaacgt tactgtccgt ctcgggacaa tgagccctac gctaattggg 137160 gtaaccgtgg ctgccgtcgt gagcgcaacg atcggcctcg tcattgtaat ttccatcgtc 137220 accaggaaca tgtgcacccc gcaccgaaaa ttagacacgg tctcgcaaga cgacgaagaa 137280 cgttcccaaa ctagaaggga atcgcgaaaa tttggaccca tggttgcgtg cgaaataaat 137340 aagggggctg accaggatag cgaacttgtg gaactggttg cgattgttaa cccgtctgcg 137400 ctaagctcgc ccgactcaat aaaaatgtga ttaagtctga atgtggctct ccaatcattt 137460 cgattctcta atctcccaat cctctcaaaa ggggcagtat cggacacgga ctgggagggg 137520 cgtacacgat agttatatgg tacagcagag gcctctgaac acttaggagg agaattcagc 137580 cggggagagc ccctgttgag taggcttggg agcatattgc aggatgaaca tgttagtgat 137640 agttctcgcc tcttgtcttg cgcgcctaac ttttgcgacg cgacacgtcc tctttttgga 137700 aggcactcag gctgtcctcg gggaagatga tcccagaaac gttccggaag ggactgtaat 137760 caaatggaca aaagtcctgc ggaacgcgtg caagatgaag gcggccgatg tctgctcttc 137820 gcctaactat tgctttcatg atttaattta cgacggagga aagaaagact gcccgcccgc 137880 gggacccctg tctgcaaacc tggtaatttt actaaagcgc ggcgaaagct tcgtcgtgct 137940 gggttctggg ctacacaaca gcaatataac taatatcatg tggacagagt acggaggcct 138000 gctctttgat cctgtaactc gttcggacga gggactctat tttcgacgga tctctcagcc 138060 agatctggcc atggaaacta catcgtacaa cgtcagcgtt ctttcgcacg tagacgagaa 138120 ggctccagca ccgcacgagg tggagataga caccatcaag ccgtcagagg cccacgcgca 138180 cgtggaatta caaatgctgc cgtttcatga actcaacgac aacagcccca cctatgtgac 138240 ccctgttctt agagtcttcc caccgaccga gcacgtaaaa tttaacgtta cgtattcgtg 138300 gtatgggttt gatgtcaaag aggagtgcga agaagtgaaa ctgttcgagc cgtgcgtata 138360 ccatcctaca gacggcaaat gtcagtttcc cgcaaccaac cagagatgcc tcataggatc 138420 tgccttgatg gcggaattct tgggcgcggc ctctttgctg gattgttccc gcgatactct 138480 agaagactgt cacgaaaatc gcgtgccgaa cctacggttc gattcgcgac tctccgagtc 138540 acgcgcaggc ctggtgatca gtcctcttat agccatcccc aaagttttga ttatagtcgt 138600 ttccgacgga gacattttgg gatggagcta cacggtgctc gggaaacgta acagtccgcg 138660 cgtagtagtc gaaacgcaca tgccctcgaa ggtcccgatg aacaaagtag taattggcag 138720 tcccggacca atggacgaaa cgggtaacta taaaatgtac ttcgtcgtcg cgggggtgac 138780 cgcgacgtgc gtaattctta catgcgctct gcttgtgggg aaaaagaagt gccccgcgca 138840 ccaaatgggt acttttacca agaccgaacc attgtacgcg ccgctcccca aaaacgagtt 138900 tgaggccggc gggcttacgg acgatgagga agtgatttat gacgaagtat acgaacccct 138960 atttcgcggc tactgtaagc aggaattccg cgaagatgtg aatacctttt tcggtgcggt 139020 cgtggaggga gaaagggcct taaactttaa atccgccatc gcatcaatgg cagatcgcat 139080 cctggcaaat aaaagcggca gaaggaatat ggatagctat tagttggtca tgccttttaa 139140 gaccagaggg gccgaagacg cggccgcggg caagaacagg tttaagaaat cgagaaatcg 139200 ggaaatctta ccgaccagac tgcgtggcac cggtaagaaa actgccggat tgtccaatta 139260 tacccagcct attccctgga accctaaatt ctgcagcgcg cgcggggaat ctgacaacca 139320 cgcgtgtaaa gacacttttt atcgcaggac gtgctgcgca tcgcgctcta ccgtttccag 139380 tcaacccgat tccccccaca cacccatgcc tactgagtat gggcgcgtgc cctccgcaaa 139440 gcgcaaaaaa ctatcctctt cagactgcga ggacgcgcac caacccctag tatcctgtaa 139500 acttccggat tctcaagcag caccggcgcg aacctatagt tctgcgcaaa gatatactgt 139560 tgacgaggtt tcgtcgccaa ctccgccagg cgtcgacgct gttgcggact tagaaacgcg 139620 cgcggaactt cctggcgcta cgacggaaca aacggaaagt aaaaataagc tccccaacca 139680 acaatcgcgc ctgaagccga aacccacaaa cgagcacgtc ggaggggagc ggtgcccctc 139740 cgaaggcacg gtcgaggcgc catcgctcgg catcctctcg cgcgtcgggg cagcgatagc 139800 aaacgagctg gctcgtatgc ggagggcgtg tcttccgctc gctgcgtcgg cggccgctgc 139860 cggaatagtg gcctgggccg cggcgagggc cttgcagaaa caagggcggt agcagtaata 139920 ataaccacac aaatattgac aataataaac gcgtacgcgg atgagtaagt gttattgtct 139980 cgcgcgccat ctttataaaa gcccgcgttg cgtgggccgg cgggtagcat ttggagggtt 140040 ggcgaccatg tcgagacctc cgacgtcaca tttggactta gctttctcgg cggcctttag 140100 gggcacggac ctgcccggag gaagattctg gcgggcgtcg cagagttgcg atattttctt 140160 ttggcccgat ctggccgcgg tgatcgtaca ggccgcccgc gcgtattttg aagggaagga 140220 aaggttgggc agtctgcagg tcgccgaaga tatcacggcg cacgacccgc gaatagcgcc 140280 cgcggctaag cgcgccgtcg cagcggcggt gggactgtgg accgcgctgt cggagttagt 140340 tggggggccg aacggggagt tggaaagcaa ggtctggggc aagcagattc cccgggccgc 140400 cgcgtgggaa ataagagacg tgcccaaagt tccagtcatt gggccggaca ttctttcttt 140460 tttctccgcc gccgtcgagc tgccggtgct ctatatcaga gcccggggag gggcgcactc 140520 gcggtccgcg cactggaata accagagcag cgcgccggcc gccggactcg cggcgataag 140580 gataggcatg gagatggtgc ggagcctcct ggtgatagcg ttgcctctgt caaacttcac 140640 cctcccggaa gacctccccg aaggttccca aaactcgatc cgcgcgttcg tggctcacct 140700 catgaactgt gtagctaccg ataagatcat gtctccggac gtgcgcgtcc cagtcgaaga 140760 aagcttttac agccactgtt taagggaaat gattatgtgc gagagagctt tttgttaccc 140820 gtgcaatccc ccgccaaaat ggtgagctca gggtcccatt tacccccgca acaccctctc 140880 gccgccaggg cgcgcgctct ctctttctct atgtcccgtc gccgccggcc taaccgaacg 140940 gtggaacggg gccgcccggg aaagcctagc tccgcacaga cacagacaga caaacggcct 141000 ctcgattgca acaacgtgaa aaacacacaa taatattact ttatttattt cgcagcgctc 141060 gcgtgtcgct cgtttctggg gggggggggg ggttgtgttt cgctgccgcg gagtgggtgg 141120 ggggggagag tggacggagg acagtgtaaa aacccgcgag gttgtcaggg acgcggaggt 141180 aaggaagccg ctagagggcg tcattctccc gtcaacggcg ccgcgccagc gccagcgcga 141240 ttccagcgtc cctcgcaaag atcgaggcgc tcacttcggg agagttggcg gcagccgcgc 141300 cggcgcgcaa ggcggccagg tattcgcgac ggcgcatctc cgattgcggg actctccccg 141360 tcccgacgcg gaaaagactc tgcacgtaaa tcgagtcgta caaacacgct tcgcggcacg 141420 gccgagggtg ccacaggcag caccagtgcc cggccgccag gagagaccgg gaggtctctc 141480 gctcggcgga cgcgaggtcg gccggcaggt gtcgggacag ccaggataac agttctttct 141540 cgatcacgaa acgcatattc tcgctctgca tggtacggct ctcgtcctcg aagcggtcac 141600 cgtccagaga gtcgagccag aaatcgccct cgatcccttc cattgcctcc tctaattctc 141660 ccaacccgtt gccgttattc gggtcagtgg gggagttggc gacgctctcc gtcgacgccc 141720 aacgcggcct caaacctagg ccgcgcgtcg cccggctggc ccccagaaaa gccgaacgta 141780 gccgttcgtt ggcagcaatc agcgcgttgc ggcggtctct cgctgacgtg aactctccgt 141840 aaccgtcctt gagttcggac gatatctcga ctaactcgcg ccagagccgc gaggcgatcc 141900 gaatgcacgg gtctaccgag tcggccgact ccgacgaggc ggcaacggca ccttgccgcc 141960 tccgctcgcc acgaggtacc gcgtgcgcag taacgtgatc gctgtccatc agcgccagcg 142020 ggtagcaccc gtcgagcatg ttttccattt agggatgtgt ctagaggaga gcggtccggg 142080 cggtctactg cggttgtgct aggccgagtt ggacggctac ggattgcgcc gggcgtgaag 142140 ggggggggcg gcgggatgtc cggcggtcgc aaaggggcgc gcgtccgctt ctgcgtgaag 142200 gccgagcggg aaagaagttc tggatgagaa tggatcgagc gggcaataaa tgtccagagt 142260 agggggatgg gagggagggg gaggttctgc cccgcgtctc ctctatctgc tcgtcgaggc 142320 ctcggccttg cgtcgccgtg caggggtcga ggccgcttct tcttttttac ttctctcctc 142380 ggattcctcg tcagaggaag aagaaaatga caacctccgt cttttaagag tgcgcctacc 142440 cgccctggcg gccgaagcct tccgtgggtc tttgcggggt gccgcgcacc gcaataacgc 142500 acggacgcgg gggatagcaa atggcggcgg cgccggagag ctgtcgtcaa taaagtctaa 142560 gtcagattgc gtgggctctg actcggtgga gctgtgtccc gtgtcctcct cgcccaagtc 142620 cactccccgg cacccaggct gctcttcctc cgactccggg tcgctccagc tcctcccgcg 142680 tgccggttct tcgtcctccg atacgtccga aaagaaaaac ttctgggaga gctcttcggg 142740 atcccaggga agctgctctg gtgactttcc gcggggcgac ggataggtct cttctggcaa 142800 gggagaggga tcactcgaca aaggactgtg gctcatatct tgcgcactgg gtcttattta 142860 ctcgtgttgt ctttccgcag ggaatgcgcg gttcgagtag gccgtggttt gcggccgttc 142920 tcggataagc acaaaatatc gccctactca cgtgtcaaaa aggaaaagtc tcaatgggct 142980 gtgaggtgat ctggagatca aagcggcact ctctttgaga agtctcttct cgagactctc 143040 tcgagtccta atgttaataa ctctggcaga ggcgcttcgt tactgacgaa gcttctgtgc 143100 atttatacgt gacgccacgc taacaaggaa gcgccgcgca atttgctcac ggttgggcgt 143160 agctctgtcc tcgagcgcac gcgaaaaatt ctcgtctcat ttccccttac cacaccacac 143220 caaacactgg tagtaaaatc gcataatgca ccccaacgtc ggaaacacag cccgagacga 143280 tgttgcttct tctttagagc cccctctttt ttaagctaca aaatttgctt tgaggccttt 143340 tcctttcttt ctttctttcg cgtgtgattg acgggggttt acgtgactac cttattagtc 143400 gtctcatatg cacggacaca tcatgggctc agcgttatta ccctaggccg cttgtaattc 143460 gttgtctgtc tacctgtctg tcaaattgtg actaccacgt accaactcct ccccaaagtt 143520 ctaccctttt ccttaaaaac acatttaaaa tgtcaaaata ccgatcctta tatttgcgtg 143580 ttatgttttc ttttgccttc taggattgat tgaattggaa tgaaacgcaa aatcttggaa 143640 taatgacgga acgcggatgc gaagaatcta caacgcgaga caggtcaata ttttttcaaa 143700 aaaggtattt tattaaatct gctataccgc tcttatatta aagaaacttt ttatttatta 143760 aattgttgtt acccccaccg tagagcaaga ccgtgatgtt ctttacgccc tcttctccgg 143820 tcgttgtgtt gtccatacat ctcgtcttcc ctcagcgctg cccgcaaatg gttcaacgta 143880 tgtcggttgg ttgactatgt cctaatatca cttcaagttt ggcgcgcgga caaaatttaa 143940 actcaatatt ctcgcgccat attccattac aaaacgcgtg acctcgacaa aattcgggaa 144000 aatctaacag cattctatct tggagaatac gctcttgcga cagaccgtgg gaaaaaatta 144060 gaaaatttac ccacggaccc cagtcccgct ttgccatttt aggaaaatgc aggaccctcg 144120 gtgcgaacgt gacgtaggtg ggtgccaccc acatcatgta aattaggtca cggggtaggg 144180 ttctggatcc gtgattggtt atgaggctcc taaagcaaac attcgcacga cggtatttaa 144240 tatattaggt gaaacctaat ttattaaata ctggagtgcg aatgtttgct ttaggagcct 144300 cataaccaat cacggatcca gaaccctacc ccgtgaccta atttacatga tgtgggtggc 144360 acccacctac gtcacgttcg caccgagggt cctgcatccc ccttccagcc aatgagctgt 144420 gacttgcctc ttcgggcact gcataaaaga acgatccggg tcgctgtccc cgcatatagc 144480 gggaccatcg ggtcctgctc ggattacccc aggaagaggg gagaagattt catactgggg 144540 acacaatggg aggggtcatt gtcttctcac atgagcaacc cgaaaatccc cccgccgatg 144600 cctccagacc acgccgacgc aggctccgtt taaagccatg cactgtccca gatggggatg 144660 ggtcgccgat cggagaggct tgtcctcacg atacacacga cccgggtcga gcacccccct 144720 cgacccccga ccctgaatgt gatcgggaag tgatattcgg cgggatgaac tcatccggag 144780 gctgcgtgac cgatactctc caagacatcg cgggttaaaa atactctacg aaagctcatg 144840 ttcgagttta cctgacccag aaaataagga cccaacaaag tcgattgtcg tgaagagcta 144900 gttaacactg aaccgccata ggcgggtttg cactttatga atttttgttt ttacttgagc 144960 tgttcggcat gtgccgggct cactacttta tttgctcttt aatagggccg ctgagttgtt 145020 tgggcccacc gacgtgcagg ttatcggctt cgttgccctt gcttattgca tacatattgc 145080 atactttcat attactgcta cgactgcgtt gtaacaccgc cagttaacac gattactggg 145140 tagatccagt atggatgtat tacgcgcatg tatatagccc gtaccttgat attataccgg 145200 ctattgcaac tcgtgctttg tttcgagcgc atctgctaag cctgcggctg cttccacgcg 145260 caagtaactg gttttagtcc cacgggcaac ccgacatagg tgcgtttcct aaaagaaacc 145320 tgtagagaca gtgccgtgac ccccgacata tatatctgga agtgtatttg cgattcaccg 145380 gcgaatcggc aagtctcctg cagagaggct cctgcgatta cttccagatc cgcgtaagaa 145440 aattacaggg acgtttgtaa atcgcaaacc agattgcgaa ctatattccc gagcatggac 145500 cttctcgcca tatctctcaa aagaagaaaa gtgccctgca aatacagaac gcatcccgag 145560 attcaaaatt tgcgattcgt gcatcccgag cggcaaatgt ctcaataaag taattatgtg 145620 ttcccgcgaa ctactcgcgt ggaacatgga accaagcttt tgcgttgtct gaatttttta 145680 tttaggctgg gttagagggg tggctagaag ataataatct ttcgtggaaa attgctagag 145740 attagaacac acaagtaaca caagtgctca cggtgatatt tacacatgtc aactctccca 145800 tatggggatc ttttttctgt cacaacttcc ttggcactcc caggaagcgt gacccatgtg 145860 ctttcgttgg cattcaaaat aaacttcact gcttcccggt gtggccaata acgtacaagc 145920 gagcgtgttt ctcgggtaat atcaatgcca acaaaacaca cgcgtgacct ttctagagta 145980 ggcacacacc ccggcaccga attgcacgta cctgtggaca caagtaatgt attgttttgt 146040 tatcttcgtc atctgttcta cagtaggctc aggtttgttt attatgttgg ctcataaaaa 146100 atgccggaag ttcctggtac ggtaatggta tgctgggcgc atggcatgca ttggctatgg 146160 cacaccggaa ctggaaatac gctcgctaac gatatgcagg ccgcatgggc gccattggat 146220 ctgaattata tcatgcctca atacaaatgc catacccaaa ccaactgcac aagaccgagg 146280 ggttgactct ccaaagttct ttcttcacaa cacctttgct gaaacctacc cagcgtggaa 146340 aggacctctt cgcaaaacgt aagtcatgaa accaatattc tgttataaat tttggggtgg 146400 gattaggtgg gctgtcatta tttgagggga ccacgaaata tccttttgca tggggtatcg 146460 tgcaaaaata tgactgtggg cttcgaataa ttcccccata cagtcaagag tatgggctgc 146520 tgttatggat gaacatgaag cgcacaaaac gataatccac ttctttagca tgtattgctg 146580 ttccaaaatt gtgcctatgg ttgcggagct ttattgtgct ctgcattgcg gggacggaaa 146640 taaacaggcc aacgcgagaa acgggaggtt tcgagagtcg cgcatcttta tttttctgtt 146700 actactcccc accagaaagc ttcacgtttc ttccaacttc tgcacaaaac ttacgtaacc 146760 ttgtcactcg ggtcttgttc tgcaggattc tggaaatcgc tagtccttcc actagcattc 146820 tatcatgtcc tctgattcct cgacgccgag taatttggcc gctccaattg ttgatgagtc 146880 gggattctca actggcccgc cctcagatct atttaccttt ttgcgcgccg ataagagtgg 146940 gcgctacgat tctttgggtt ctcccatccc gaaccctcca aacgcaccta cctgtgagac 147000 cactactgat agcttttcgt acagcacgcc acctcttttt tccagcgagg acgagctctt 147060 tcactctgtc atcgctgaga atgcggccca agacgtggac gggcgagaaa tgtctctccg 147120 cgaccttata gcgatgttaa acgacatgga tcccgaaaac ataaactcta tagaaccgtg 147180 tccgaacgct accagtgatg tcgtggcact agatattaac gtggataccg atcagcccgg 147240 agtttatgcg gtcatcgact cgctcgcgca tccctgcgaa actcccatgg agcagcagca 147300 cgttgaatgc ccgtgtccat tacctgcagt agagaaaaca accgctgtga ggcgtcaaga 147360 agtggtgagg aagtcagaga gagtggccag atctcgttcg cgacgcgccg tggcgcgatc 147420 tttgagcaac cggcgccccg tcccttcgcc gcagaggacc agcaaagacc gtctccccga 147480 gcgagggaag agggaatttt cgaagaagat gggcccgagc caccttacct cttcctcctc 147540 ttcctcctct tcctcattct cgctgtcagg gaggagggga cgtctcgccc gaaggctgga 147600 aagcgcagga agtgaaaaat ccaccgaaag ccccgaccgg gactctgccc aattagtgct 147660 acctggagaa tgtcccgatg tcgcgctaga gccactctgg cgagttttga gggagtgggt 147720 cgaaacggac ggtacagacg ggtcggttca gtcagtaacc gcgcctacgg agctcccaga 147780 cctaggccgc ggcattaccc tgaatgtact ctcacgagcg ttggccgtcg acctccatag 147840 ttccgaggct cgcgtttttg ttccagaagc tattatccca tccccaccca gtagaggaca 147900 agtatatcat ggaagtggct atagacagtc tttggtcgat gacccgcagg ttcgggaggc 147960 cgcggccgaa ttccatgcca atccgaaatc agcttccgtg tatctcgaag agtacgggat 148020 gccagtggaa cagttagagc gccttgtgga ggagttcatg gtccagcccc tgtcgcgcgt 148080 ttcgtatggg tatggtggcc ccaagctgag cccacgtgac aaacggctct gcgaactgtg 148140 cgctctccgc ggtccgggtt cttccgaggg aggattgtct cgttctgcgg tgccgacgtg 148200 ccttccgcac gtagcgcacg ccatgcgtga tggccgtgtg tcattagctc tgccgcacct 148260 taccgagctc gtacgcgtgt gccgccgcta tgaccacccg cagaaaactt acctgttggc 148320 ggctcttagg agagcgtttg tcccgtttgt atttccagga gcggccgtgg atcctacggc 148380 ggcgtctgct tctggggacc accctgtact cgttggcgcc aggcgaatag cgcgtgccac 148440 gagggagctg gaggccgcag cgaaagagcc acctgcggca accccggaaa aactttcctc 148500 ttcggcgcta ttgcgccata ctagaacttg cattgttgct gccgcagatc tcatggcggc 148560 gcttactgct atagactgcc caccagttac aataaacccc gccaagcgtc gcccggatct 148620 gtatcaagca ctctcgaggg cgcccaaaac agtctttacg tgggagcgcg ccatgcgcta 148680 ctgcgcggct tcgctatgga gtcgcctcgt catagggtcc ctgccgctgc catctaccga 148740 tgatgtcact cttcttgtag aagccatgga agctgccgtg ggcgtgcttg gctgctccga 148800 cgagggtgac gtgcggcctt caattgccta cgcggcctct ggttggagga tgatcgctac 148860 catgctagga gatgattccg cgcccggcag cgagcacgtc acggacgatt gtcccgcaga 148920 tgatgacacc caccaccatg acaggcgcaa aagacgaggc ggccggcgga gcacttgccg 148980 gtacgaccta cctcccggca ctcccgatcg cgcggcccac ctcctactct acgggagtcc 149040 tggcggcggc aacggagcag agccttcggc tgcccaagaa tctcccgcca acccctggcc 149100 cagagctcca ccgtgcgatg aacaggagcc attatctgtg tcaccgtacg ggcccgaacc 149160 cgaccgccct ccagatgatg actttgagac ccgtaaaggt ctgaaaagaa agtcatctga 149220 agatcacgcg gacccgatcc cagaaggcaa cgcgactaaa aaaacatgtg gcctccaggg 149280 cttaccagat tcattacctc cagcggttcc agaaacagat agagacaacc tcctcctttc 149340 gccatgcccc ataactcccg agggtccacc atgtccgccc cgagaagaac cgcaagaacc 149400 acaatccccg tcctttcaca tttccgagat aggtgaggcc ctgtttcatt ctaccccaat 149460 cagccctacc atcctgttcg caccggaggg tttcatcccg aaccaagggg atgtttaccg 149520 tccccatggc aaaaacttgg gcgttgcgct ctccgcaggg gagccatacg tgcccgccca 149580 tcgcgcgcgt cctgctttgg agcggctcgc gaactatttg cgcgggttga gcagcggtcc 149640 ggcgggaagc tattccgcga ccggacccgc agattggcta cctgcttttg cgagggaccc 149700 agtagccctg ggggagtttt gcaagaggat ttcacccgtg aacagagggg ggcgctgcgt 149760 cttagaggag cggctttcct ggacgttgcg acatccggct gacaaaatct atgacctcat 149820 cattcttgtc tcagaacgtg ccccgggcga atttttagaa cgcgcgtacg cctacgcggc 149880 cctctgcgga cgtgcctgca tgccgggcgg tgcctgttgg ccagaatcgt ggacacgtgg 149940 ggagtatccc tatatccctc ccgacgagaa agacccgggc cgcagcgtgg ccattctctg 150000 tacgacagac cttggatacg ccggggcggt agaatggatg cttgagcgcg ctctcagtac 150060 atctgggcgc gcatgcgtgg tcgtagatgc tagggatccc ggggacgagg attcccgctc 150120 gggtccgcgc atacctaccg ggcggagggg tgttgtctat gcccggacta gtcccccgtc 150180 gcacgcttac cttgtaaaac tgtttaccgg tccggtggcc gaacggttgg aacggggtgg 150240 gctcaatgta ggtcacgtag taatggacag gcgactcgct gtctcatggc ccctcagcgt 150300 tgggaagacc gacaacgacg atgagggtac aggagacaga gagaagtgtc ctcccgttaa 150360 gcaccccttc ctcactcacg taactctcag gagactacgc gacgttgctc gtgccatgga 150420 tgccgggtgg agccactccg aaatcggaaa agcttcagcc gtcttgtatc cgtacatggc 150480 ccagccccat gtgggcgccg gggcgatgcc gccatgtccg gacctttccg agtccagttc 150540 cactatgcat tcttcttcgt cgtcttcctc ttcctcatgc tcctcgtcgt cgtcttcttc 150600 agactccagc tcatctgaag aagacgggga cgagaagaac gagaaagaag atcgtgagcg 150660 cgccggaggt ggaaagcggc gcggccgcca gcgcctcctg attcgggacc gcgtgtaccg 150720 tggccgggac taccgcgtgc gcactccctg cgctgatatt gtgggaggca cttccgcttc 150780 ctttagggcc gtcgctgcgt gggggaggga cacggtaatt cccgccctcc ctctcgcagc 150840 atcctggtcc gatcccagca aaattccaca ggaagttctc cgcatcatct ccgattatta 150900 cccggatgcg ccaggggcgc gggcgcgtcg gaacccgctt cacgtggaag gactagcgct 150960 tatgcgtgcc agaaatcccg cccctctcgc attgctactt ggtgacgact attcccatta 151020 tcacactccc cgcaatcggt ccccaatgtg ttgttgctgg agtgctccgc ggggagcaac 151080 gccagagtca cccagatgca ccggacacac gcgcaccagg cgcccaaggc tatccgtctc 151140 ctcagggagg ggggaaacta gaacccttgt acccagatta gactcttcag aggataggcg 151200 gtcgcgtcaa cgccatagac gcatgactaa ctaccctcta ccgcatccca ctgtcactga 151260 cccttggtgg taaccgtggt ttccgttatt aacttaactt attaaaactt tttgtacaat 151320 ttacttctgg ttgcgtgctc attcttttgc tagtcggagc ttgtcagcca ccgacgactt 151380 gtagaaaaag accggggaaa tgatctagcc ccgttgactt tagctttgct gaacattcta 151440 cccgtgcggc catggagtga tattagaaaa gggacgagaa tgggggcaag tacgaatatc 151500 gggaggaggc ggaacgaggt gttaagtaat gcacttgaat atttaattcg ttcattttga 151560 tacataagat ccacggaagc ttgtaatgct ggccggcagc attattacta ttgcaagcgc 151620 cgatataaaa atcgcaatca aaatactaga ttgtctagta ttgcctgctc tgacggacgt 151680 aacgtctctg tagggcgttc gccaggtcat tcaggaacga cttcatcaaa tacgaatcct 151740 ccactgttat agggcacggt gcctgtaata aataggagat acaatgttag actcgtcatg 151800 cgaccaataa ggaccgcgtg agcacggaga caaaagatgt ctcggagata ctgtgctgcg 151860 cgttagatag tctcttcaaa gtacagaatg cgcgatgctg ccattatctt accttgcgag 151920 agctaccgcc attactgaca gaattcagca cgtaatacaa attgacgtag agcccctgca 151980 gttttttgtg acactgttgg tgtttcaaaa tgaccgaaag ggattggcac aactcttcag 152040 tttcgtttag acgctgcagg aaaagcaaga ttcgttaata aaccgccgag cagattattg 152100 ggcagggtag acctaagcaa aaaatctaca tttttaatct ggggctagcg cgcggccggc 152160 ctccagggca ttgccgttga gaacatgtga caaatgagct ggcttttact caccgtgtcg 152220 gacgtaaaga tgttcggaac tcttctaccg tcgcaggaac ccttataagg aaacgagaga 152280 gcctacagtt atgaacgtga acatagactg aatagccgta catagttaca aagaccgtgc 152340 aggcatgtca gcatggtcca acgagaatga gttgccttac gtccttctgc acacggtgca 152400 gtattctgat gctctccgcc agtaacttca agggtgccgc gcgtatactg cgagcatccc 152460 cgactccaag tagtaacacc agtaacgcca gtgcggcgga caatggaggc ttcgacttgc 152520 caggcattcc caccgcgcgc aaccgccgcc gcgaaacttc tcccctagtt ctccctctgg 152580 gttcttccct aaggatacac tgccaccatt tatatagctt tacgtggcgg gaaagcccta 152640 gcccccacta tacccggaag cggctacact agagcccttg caagagcaga aaattttccc 152700 gccgtgggtt gcgcgtgaac aacttaccag aacgagaatt tttgaaacct ctgagactca 152760 cagcacgtgc ttacgaatac cagaaactgg gagcacggtg cttccgcgac actctacaaa 152820 gataagtgcg ggcacagtta ggtgctactg cgcttagcta agtgcttaac ctgagtagca 152880 cctaattgcg gccttaggcc aaggtgtcgt tacccggata gctttcacat cgatagcgcg 152940 tattaccttc ggcctgacaa ctgtcagcta cccaaccgct ctgtcttctt tcaatccttg 153000 actattataa ctcgcggtaa ccggccgtgg ccacatagtg aggcggttat acggaataag 153060 accccccccc cccccccggg gccttcacgt tcgtgtccgt tcttgccagt gagcgttgct 153120 ggaaatcgaa aattccagtg tggcgcttat tgtgcaagaa ccacgggcgt gacctgtatg 153180 actactgagc aaagcacctc gcgctgccgc gaaacttaca aacggggcga actgcgtgac 153240 gattctgtga tcgcgcttcg aggtccagtc ggagcccacc ggtgcccacc tgaacctttt 153300 cagctccgga aaaggctaaa ctggaaaatc tagtagaact agtttcacgg ctgcccgcgc 153360 tgaccgtttg ctctccacgg gtggaagaac ttgggggggg ttggcggacg ctggcgtttg 153420 atgtcgggcc gtcaagtatc tcgcaacccc agaacctgtc cagcatctaa tagtaggggt 153480 cggacatgaa accacaaggg attggaaggg cggggagcac tcaggggact gggaggggac 153540 gggtcggaga aaaccgcgga ccaccagtgc acacaccctg catccttggc tgctcatata 153600 tagccccccc ccgcaaaaca cccccccggg tttattgccg acgacggggc tgtggagc 153658

Claims (12)

  1. 서열번호 15로 기재되는 염기서열을 갖는 닭 전염성 후두기관염 바이러스가 약독화된, 기탁번호 KCTC 13022BP로 기탁된 닭 전염성 후두기관염 바이러스(Infectious laryngotracheitis virus; ILTV) 약독화주.
  2. 삭제
  3. 삭제
  4. 제 1항에 있어서, 상기 약독화주는 세포주계대에 의해 약독화(Tissue Culture Origin, TCO)된 것을 특징으로 하는 약독화주.
  5. 제 4항에 있어서, 상기 세포주계대는 닭 유래 세포에서 20 내지 40회 수행하는 것을 특징으로 하는 약독화주.
  6. 제 1항의 닭 전염성 후두기관염 바이러스 약독화주를 포함하는 가금류 전염성 후두기관염 예방용 백신 조성물.
  7. 제 6항에 있어서, 상기 가금류는 육계, 산란계, 칠면조, 오리, 거위 및 메추리로 구성된 군으로부터 선택되는 어느 하나인 것을 특징으로 하는 가금류 전염성 후두기관염 예방용 백신 조성물.
  8. 제 6항에 있어서, 상기 백신 조성물의 형태는 생독 백신, 사독 백신, 약독화된 전염성 후두기관염 바이러스주의 유전자를 사용하여 생산한 서브유니트 백신, 벡터 백신, 키메라 백신 및 DNA 백신으로 구성된 군으로부터 선택되는 것을 특징으로 하는 백신 조성물.
  9. 제 6항에 있어서, 상기 조성물은 수의학적으로 허용가능한 담체를 추가적으로 포함하는 것을 특징으로 하는 백신 조성물.
  10. 수의학적으로 허용가능한 양의 제 6항의 조성물을 가금류에게 투여하는 단계를 포함하는 보호성 면역 반응 유도방법.
  11. 수의학적으로 허용가능한 양의 제 6항의 조성물을 가금류에게 투여하는 단계를 포함하는 가금류의 면역반응을 증가시키는 방법.
  12. 제 10항 또는 제 11항에 있어서, 상기 투여는 접안 접종인 것을 특징으로 하는 방법.




KR1020160122049A 2016-05-26 2016-09-23 닭 전염성 후두기관염 바이러스 약독화주 및 이를 포함하는 백신 조성물 KR101827767B1 (ko)

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Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Gallid herpesvirus 1 strain Poulvac ILT(R), complete genome(GenBank: KP677882.1, 2015.12.31.)
PLoS ONE, 2016.02.18., vol. 11, no. 2, E0149529, pp. 1-19.*
Science. 2012, Vol. 337, no. 6091, p. 188.
Virology. 2013, vol. 440, no. 1, pp. 64-74.

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