CN114717200B - 一株马立克病病毒特超强毒株及其基因缺失毒株的构建和应用 - Google Patents

一株马立克病病毒特超强毒株及其基因缺失毒株的构建和应用 Download PDF

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CN114717200B
CN114717200B CN202210261757.0A CN202210261757A CN114717200B CN 114717200 B CN114717200 B CN 114717200B CN 202210261757 A CN202210261757 A CN 202210261757A CN 114717200 B CN114717200 B CN 114717200B
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罗俊
滕蔓
郑鹿平
张改平
王伟东
刘金玲
赵东
程娜
柴书军
邢广旭
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Henan Academy of Agricultural Sciences
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Abstract

本发明提供了一株马立克病病毒MDV特超强毒株HN302及其基因编辑缺失毒株的构建和应用。本发明HN302毒株于2021年11月18日保藏于中国微生物菌种保藏管理委员会普通微生物中心，保藏编号为：CGMCC NO.21929。本发明提供的MDV毒株HN302是从国内疫苗免疫鸡群爆发马立克病MD临床病例鸡群中分离得到的，可代表当前国内优势流行毒株。通过病毒分离培养、基因克隆测序、遗传进化分析、间接免疫荧光实验、SPF鸡攻毒致病性分析以及MDV致病型鉴定等，将HN302毒株定义为MDV特超强毒株。该毒株的病毒基因组序列SEQ ID NO.1全长175700bp。本发明是国内第一个致病型鉴定依据最充分的MDV特超强毒株，可作为亲本毒株用于MD新型高效基因工程疫苗、多联多价疫苗和传代致弱疫苗的研发、创制和应用。

Description

一株马立克病病毒特超强毒株及其基因缺失毒株的构建和 应用
技术领域
本发明涉及一株马立克病病毒特超强毒株及其基因缺失毒株的构建和应用，属于动物病毒学领域。
背景技术
马立克病病毒(Marek’s disease virus，MDV)属于甲亚科疱疹病毒，基因组全长约170-180kb。MDV共有3种血清型：血清I型(MDV-1)、血清II型(MDV-2)和血清III型(MDV-3，即HVT)，其中只有MDV-1具有致病性，早期感染雏鸡可引起法氏囊及胸腺萎缩、外周和中枢神经组织损伤而引起严重的免疫抑制、翅腿神经麻痹以及内脏组织多器官的T细胞淋巴瘤，最终导致鸡群大批死亡，对养禽业危害极其严重，每年导致全球直接经济损失10-20亿美元。不同MDV-1流行毒株的致病性强弱差别较大，根据毒力的不同可分为弱毒MDV(MildMDV,mMDV)、强毒MDV(Virulent MDV,vMDV)、超强毒MDV(Very virulent MDV,vvMDV)以及特超强毒MDV(Very virulent plus MDV,vv+MDV)。
MDV感染宿主诱发的肿瘤可以用病毒疫苗进行有效的免疫预防，这是世界上第一个可用病毒疫苗成功预防肿瘤和癌症发生的案例。当前，我国用于MD免疫预防的疫苗毒株，主要有MDV-1疫苗株CVI988/Rispens、814和HVT代表株FC-126，更早一些时期也曾广泛使用过MDV-2的SB-1株，这些疫苗株在MD的有效防控中发挥了重要作用。虽然疫苗的广泛应用可以较好地预防MD肿瘤的发生，但由于持续的免疫压力和病毒的自身进化，近年来MDV的毒力不断增强，部分毒株已经突破了现有MD商品疫苗的免疫保护，vv+MDV及部分变异株的出现及潜在的流行，已经导致疫苗免疫鸡群中仍不断有MD的爆发和流行，给世界和我国的养禽业造成了严重经济损失。
根据过去近50年间针对MDV毒力进化规律的研究发现，MDV每15～20年会有一个大的毒力增强的演化。最近5年，我国疫苗免疫鸡群MD爆发的案例也迅猛增加，这将预示着新一轮的MDV毒力增强可能正在发生，但当前我国鸡群是否广泛流行vv+MDV尚缺乏充分证据。从我国MD疫苗免疫鸡群发病的临床病例鸡中分离鉴定具有自主知识产权、毒力更强的MDV毒株，可为现有疫苗免疫效力评估及新一代MD高效疫苗的研发和创制提供重要的依据和材料。
发明内容
针对现有技术的不足，本发明的目的是提供一株马立克病病毒特超强毒株及其基因缺失毒株的构建和应用。
为了实现上述目的，本发明所采用的技术方案是：
一株马立克病病毒特超强毒株，所述马立克病病毒特超强毒株为马立克病病毒HN302，已保藏于中国微生物菌种保藏管理委员会普通微生物中心，保藏编号为CGMCCNO.21929。
所述马立克病病毒株HN302的病毒全基因组核苷酸序列全长为175700bp，如SEQID NO.1所示。
所述马立克病病毒株HN302为马立克病病毒特超强毒株vv+MDV。
所述的马立克病病毒特超强毒株HN302构建的MDV基因缺失毒株。
所述MDV基因缺失毒株是以马立克病病毒株HN302为亲本毒株，构建的MDV单基因或多基因缺失疫苗候选毒株。
构建MDV基因缺失毒株的方法，包括但不仅限于利用CRISPR/Cas9基因编辑技术、细菌人工染色体BAC技术或基因同源重组技术；所述缺失基因包括但不仅限于MDV蛋白编码基因或非编码RNA基因。
所述缺失基因包括但不仅限于meq基因缺失、miR-M11基因缺失或LAT-miRs基因缺失。
所述的马立克病病毒特超强毒株HN302在MDV疫苗研发和创制中的应用。
所述的MDV基因缺失毒株在MDV疫苗研发和创制中的应用。
所述MDV疫苗为鸡马立克病MD基因工程疫苗、鸡马立克病MD多联疫苗、鸡马立克病MD多价疫苗或鸡马立克病MD传代致弱疫苗；所述鸡马立克病MD基因工程疫苗为基因缺失、基因重组或载体疫苗；所述应用包括但不仅限于利用所述马立克病病毒特超强毒株的病毒粒子、病毒核酸DNA或全基因组序列信息。
本发明有益效果：
1、本发明分离鉴定的MDV特超强毒株HN302，是从河南省漯河市某养禽场MD疫苗免疫后爆发疫情的蛋鸡群中分离得到的，可很好的代表当前国内鸡群流行的MDV优势毒株，毒株来源和背景清晰。本发明证实该毒株可突破第一代MD疫苗HVT和第三代疫苗CVI988的免疫保护，为揭示国内免疫鸡群仍爆发MD的免疫失败成因提供了重要科学依据。
2、本发明通过一系列研究和实验，将HN302定义为MDV特超强毒株，是国内第一个提供最全面可靠实验依据的特超强毒株，包括从病毒分离培养、meq基因测序、遗传进化分析、血清型IFA鉴定、病毒全基因组测序分析，尤其是基于1日龄SPF鸡攻毒实验的动物致病性分析和基于MD疫苗免疫攻毒保护指数评价的MDV致病型鉴定实验，填补了我国自主知识产权MDV特超强毒株的空白。
3、本发明提供的MDV特超强毒株HN302及其全基因组序列，可作为亲本毒株利用CRISPR/Cas9基因编辑等技术，构建一系列的MDV单基因或多基因缺失疫苗候选毒株，如meq基因缺失的HN302Δmeq、miR-M11基因缺失的HN302ΔM11、LAT-miRs基因缺失的HN302ΔLAT等单基因缺失候选毒株，以及双基因缺失候选毒株HN302ΔmeqΔM11和HN302ΔM11ΔLAT。可为新一代MD高效疫苗的创制奠定重要基础，同时也可为其他家禽病毒的基因工程重组疫苗提供载体，还可为现有的MD商品疫苗及后续研发MD疫苗的免疫效果评价提供重要的攻毒种。
附图说明
图1 MDV-1细胞培养物和分离株meq基因的PCR鉴定结果。
其中：A表示CEF细胞培养物的meq基因PCR扩增结果；B，表示病毒单噬斑克隆的meq基因PCR扩增结果；M，表示DNA分子量Marker；图1A中1～7，表示MD临床病例鸡的样品编号；图1B中1～6，表示纯化的病毒单噬斑克隆号。
图2 HN302与MDV参考毒株meq基因的系统发生树分析结果。
图3 HN302毒株的间接免疫荧光实验IFA鉴定结果。
其中：Plaque，表示普通光照下的MDV病毒噬斑；IFA，表示间接免疫荧光实验染色的MDV荧光噬斑；MDV-pp38-BD1，表示MDV-1特异性的pp38单克隆抗体；REV-gE-11B118，表示REV的gE单克隆抗体；ALV-J-6D5，表示ALV-J的单克隆抗体。
图4 HN302攻毒鸡的体重及免疫器官指数分析计结果。
其中：HN302，表示攻毒的MDV毒株；CEF，表示阴性对照。
图5 HN302攻毒SPF鸡的存活曲线图。
其中：HN302，表示HN302攻毒的MDV感染组；CEF，表示阴性细胞接种的对照组。
图6 HN302攻毒疫苗免疫鸡的存活曲线图。
其中：HN302、Md5，表示攻毒组使用的MDV毒株；HVT、CVI988，表示免疫组使用的MD疫苗；None，表示非疫苗免疫阴性对照组。
图7 HN302△meq基因编辑缺失毒株的PCR鉴定及测序分析结果。
其中：A，表示HN302 meq基因编辑产物的PCR鉴定；B，表示HN302与HN302△meq基因编辑序列的比对分析；C，表示HN302△meq基因编辑PCR产物的核苷酸序列分析图谱；D，表示meq基因编辑缺失毒株HN302△meq的传代稳定性PCR分析；
M，表示DNA分子量Marker；HN302，表示野生型毒株；HN302△meq，表示meq基因编辑缺失毒株；CEF，表示鸡胚成纤维细胞阴性对照；P5、P10、P15，表示HN302△meq的传代次数；DSB和粗箭头，表示基因编辑剪切的DNA双链缺口；gRC/gRN，表示靶向meq基因的上下游gRNA；虚线箭头，表示meq基因序列中的gRNA靶点；PAM，表示靶基因的前间隔序列邻近基序。
图8 HN302Δmeq基因编辑缺失毒株的IFA鉴定结果。
其中：Plaque，表示普通光照下的病毒噬斑；IFA，表示meq单抗间接免疫荧光实验特异染色的病毒噬斑；HN302，表示野生型毒株；HN302△meq，表示meq基因编辑缺失毒株。
图9 HN302△M11基因编辑缺失毒株的PCR鉴定及测序分析结果。
其中：A，表示HN302的miR-M11基因编辑产物的PCR鉴定；B，表示HN302与HN302△M11基因编辑序列的比对分析；C，表示HN302△M11基因编辑PCR产物的核苷酸序列分析图谱；D，表示miR-M11基因编辑缺失毒株HN302△M11的传代稳定性PCR分析；M，表示DNA分子量Marker；HN302，表示野生型毒株；HN302ΔM11，表示miR-M11基因编辑缺失毒株；CEF，表示鸡胚成纤维细胞阴性对照；P1～P15，表示HN302△M11传代的次数；DSB和粗箭头，表示基因编辑剪切的DNA双链缺口；gR3/gR6，表示靶向miR-M11基因的上下游gRNA质粒组合；虚线箭头，表示miR-M11基因序列中的gRNA靶点；PAM，表示靶基因的前间隔序列邻近基序。图10HN302ΔM11编码的的miRNA相对表达水平RT-qPCR分析结果。
其中：HN302，表示野生型毒株；HN302ΔM11，表示miR-M11基因编辑缺失毒株。图11HN302ΔM11基因编辑缺失毒株体外增殖曲线的测定结果。
其中：A，表示以meq基因为参照的病毒基因组拷贝数；B，表示以gB基因为参照的病毒基因组拷贝数；HN302，表示野生型毒株；HN302ΔM11，表示miR-M11基因编辑缺失毒株。
具体实施方式
以下结合实施例对本发明的具体实施方式作进一步详细说明。如无特别说明，实施例中所涉及的仪器设备均为常规仪器设备；涉及试剂均为市售常规试剂；涉及试验方法均为常规方法。
实施例一：MD临床样品采集及病毒分离培养
河南省漯河市某养殖场120日龄海兰褐蛋鸡群发病，病鸡临床表现为呆立、缩颈、羽毛蓬松、拉黄色稀便，大部分鸡发育不良、极其消瘦，个别病鸡伴随肢体劈叉、扭颈歪脖等神经症状。鸡群发病率高达35％，死亡率约15％。对发病和死亡鸡进行剖检，发现大部分病死鸡呈现肝脾肿大，部分鸡有一种或多种内脏器官局灶性肿瘤或弥散性肿瘤结节，临床诊断为MD疑似病例。
取上述疑似病例活鸡7只，依次编号为1～7，翅下静脉无菌采血2～3mL，并添加肝素钠抗凝。按鸡外周血淋巴细胞分离液试剂盒说明书操作，分别提取外周血淋巴细胞，接种至提前制备好的6孔板CEF单层细胞(1孔/只)，孵育3h后弃去淋巴细胞，更换含2％(v/v)FBS(胎牛血清)的M199培养基，38.5℃、5％CO2培养箱培养5d，第一代CEF细胞未出现明显的病毒噬斑，消化细胞盲传至第二代，培养7d后显微镜下观察，部分接种孔出现典型的病毒噬斑。消化收集细胞，取一半细胞悬液，按照细胞/组织/血液基因组DNA提取试剂盒说明书操作，提取细胞培养物总DNA，测定浓度后，稀释至工作浓度(10ng/μL)准备进行下一步的PCR鉴定；另一半细胞悬液，采取有限稀释法进行梯度稀释，分别转接至新的6孔板CEF单层细胞，进行下一步病毒的克隆、纯化和鉴定。
实施例二：MDV流行毒株HN302的克隆、纯化和鉴定
1、细胞培养物的PCR初筛与鉴定
针对MDV-1特异性致瘤基因meq序列的保守区，设计合成用于meq基因PCR扩增的引物对：meq-F 5’-ATGTCTCAGGAGCCAGAG-3’(SEQ ID NO.2)和meq-R 5’-TCAGGGTCTCCCGTCA-3’(SEQ ID NO.3)，然后对实施例一制备的第二代病毒分离细胞培养物的DNA样品进行PCR鉴定。
PCR反应体系包括：2×EasyTaq PCR SuperMix(+dye)10μL、10μM的上下游引物各0.5μL、10ng/μL的待检样品DNA模板1μL以及灭菌超纯水7.5μL。
PCR反应程序如下：94℃预变性4min；94℃变性30s、58℃退火30s、72℃延伸1min，进行30个循环；72℃延伸5min；4℃保温至取出。
PCR扩增产物用1％(w/v)琼脂糖凝胶电泳(150V，300mA，30min)进行分析鉴定。电泳结果显示：1号、3号和7号DNA样品均扩增出大小分别为1179bp和1020bp的2个特异性条带，分别指示MDV-1疫苗株CVI988或814的长meq基因(L-meq)和MDV-1流行毒株的短meq基因(S-meq)；而2号、4号、5号和6号DNA样品均仅扩增出大小为1020bp的1个特异性条带，指示MDV-1流行毒株的短meq基因(S-meq)(图1A)。
上述结果表明，该鸡场发病的蛋鸡群为CVI988或814疫苗免疫鸡群，但因感染可突破MD疫苗免疫保护的MDV-1流行毒株而发病，2号、4号、5号和6号病例均携带田间野毒株，可用于MDV-1流行毒株的分离和鉴定。
2、病毒分离株的纯化与鉴定
将实施例一取得的2号、4号、5号和6号发病鸡的另一半细胞悬液样品进行稀释，采取有限稀释法转接至新的6孔板CEF单层细胞中，置38.5℃、5％CO2培养箱中培养3～5d，待显微镜下观察到明显病毒噬斑后，将6孔板置显微镜下操作，挑取单噬斑转接至新的24孔板CEF单层细胞中，置38.5℃、5％CO2培养箱中培养3d。然后同上所述，用meq基因扩增引物对meq-F/meq-R进行PCR鉴定，阳性孔按照同样方法进行第二轮有限稀释和病毒单噬斑纯化。经过连续两轮的病毒单克隆纯化后，随机挑选6个病毒克隆进行PCR鉴定，结果表明各个样品均仅扩增出一个1020bp的短meq基因特异性条带(图1B)，表明该分离株已得到纯化，并将其命名为HN302，进一步扩大培养后冻存于液氮。
3、meq基因的克隆测序与分析
用上述分离纯化的HN302病毒株接种CEF单层细胞，置38.5℃、5％CO2培养箱中培养3d，显微镜下观察到明显噬斑后，用胰酶消化处理并收集细胞，按照细胞/组织/血液基因组DNA提取试剂盒说明书提取细胞总DNA，测定浓度后稀释至10ng/μL，用上述引物对meq-F/meq-R进行meq基因PCR扩增。扩增产物用1.5％(w/v)琼脂糖凝胶电泳分析，切胶回收目的产物进行纯化，然后连接至pMD19-T载体，16℃连接过夜，连接产物转化DH5α感受态细胞，过夜培养挑取单菌落，用上述meq-F/meq-R引物对进行菌液PCR鉴定，阳性菌送样至生工生物工程(上海)股份有限公司，按照常规方法进行测序分析。
用MEGA6.0软件对HN302与GenBank数据库中已注释的国内外MDV参考毒株的meq基因进行遗传进化分析，构建系统发生树。分析结果显示：与参考毒株相比，HN302与国内分离的GX18NNM4、SD2012、GX0101等强毒株亲缘关系较近，处于同一个大的遗传进化分支上(图2)。用MegAlign软件对HN302与GenBank数据库中已注释的MDV参考毒株的MEQ蛋白氨基酸序列进行同源性比对分析，结果显示HN302的MEQ蛋白氨基酸序列仅含有3个4-脯氨酸重复区(PPPP)，符合MDV-1强毒株特征。
4、间接免疫荧光实验IFA鉴定
取HN302病毒种，接种至48孔板CEF单层细胞上，置38.5℃、5％CO2培养箱中培养3d。显微镜下观察出现明显的病毒噬斑后，弃去细胞培养基；每孔加入200μL甲醇/丙酮(v:v＝1:1)细胞固定液，室温静置10min；弃去固定液，然后用PBST(含0.05％(v/v)Tween-20的PBS溶液)洗3遍，甩干；用含5％(w/v)脱脂奶的PBST封闭，500μL/孔，置37℃孵育30min；弃去封闭液，PBST洗3遍，甩干；分别孵育MDV-pp38-BD1(MDV-1特异性的pp38单克隆抗体，由英国Pirbright研究所Venugopal Nair教授馈赠)、REV-gE-11B118(REV的gE单克隆抗体，由山东农业大学崔治中教授馈赠)和ALV-J-6D5(ALV-J的单克隆抗体，由山东农业大学崔治中教授馈赠)单抗稀释液，100μL/孔，37℃孵育30min；弃去单抗稀释液，PBST洗3遍，甩干，加DyLight 488 Goat Anti-Mouse IgG(山羊抗小鼠IgG、1:1000)二抗稀释液，100μL/孔，37℃孵育30min；最后用PBST洗3遍，加PBST溶液100μL/孔，置倒置荧光显微镜下观察结果。
结果显示：HN302接种至CEF单层细胞，3d后即可形成MDV特异性病毒噬斑，且病毒噬斑可与MDV-pp38-BD1单抗特异性结合呈现绿色荧光染色；REV-gE-11B118和ALV-J-6D5单抗则均无特异性结合，未呈现特定的荧光染色(图3)。上述结果表明，HN302为MDV-1流行毒株，且不存在REV和ALV的共感染或外源污染。
实施例三：HN302的致病性分析及致病型鉴定
1、HN302的病毒效价测定
复苏液氮冻存的HN302病毒种，37℃水浴迅速溶解，1,000r/min离心5min后，弃去细胞冻存液，用1mL含2％(v/v)FBS的M199培养基重悬细胞，充分混匀后吸出900μL，在24孔板上用含2％(v/v)FBS的M199培养基将HN302病毒液按照2-1～2-12进行倍比稀释；然后将2-6～2-12稀释度的病毒液，重悬后转接至48孔板CEF单层细胞中，300μL/孔，每个稀释度做3个重复，最后一列细胞孔直接补加2％(v/v)FBS的M199培养基作为阴性对照，置38.5℃、5％CO2培养箱中培养3-4d，显微镜下观察出现典型病毒噬斑后，选择噬斑个数较为适中(15～30个/孔)的连续3个稀释孔，按照实施例二所述的IFA方法，用MDV-pp38-BD1单抗和DyLight488Goat Anti-Mouse IgG(1:1000)二抗进行病毒噬斑染色，最后置倒置荧光显微镜下进行病毒噬斑计数。将每个稀释度的3个重复细胞孔中病毒蚀斑数的平均值乘以对应的稀释倍数，计算获得HN302病毒种的病毒效价为2.73×104PFU/mL。
2、HN302的致病性分析
1日龄SPF白来航鸡66只，随机分成2组，分别作为HN302攻毒组和CEF阴性对照组。HN302攻毒组按照2000PFU/200μL/只的剂量进行腹腔接种，同时阴性对照组小鸡腹腔注射等量CEF阴性细胞，分别饲养于正压鸡隔离器中。攻毒后7d、14d和21d，两组鸡各取5只处死，称重后剖检观察，同时采集胸腺和法氏囊并称重，统计分析免疫器官指数(胸腺/体重比值和法氏囊/体重比值)；攻毒后逐日观察并记录实验鸡的健康状况，同时对病死鸡进行逐只剖检，记录肉眼肿瘤发生情况，统计肿瘤发生率、绘制存活曲线；至75d试验结束时，处死全部存活鸡，剖检观察内脏肿瘤发生情况。
经最终统计分析的动物实验结果显示：与阴性对照组相比，HN302攻毒组实验鸡的体重和胸腺/体重比值均未观察到明显差异(图4A和图4B)，但法氏囊/体重比值在攻毒后21d差异显著(图4C)；自攻毒起始至感染后第75d实验结束，阴性对照组实验鸡未观察到任何发病或肿瘤发生，HN302攻毒组实验鸡虽然发病较晚、存活率下降较为缓慢(图5)，但最终的累计发病率、死亡率和致瘤率分别高达100％、54.84％和87.10％(表1)。
表1 HN302攻毒鸡的累积发病率、死亡率和致瘤率
Figure BDA0003550384720000071
3、HN302的致病型鉴定
1日龄SPF白来航鸡220只，随机分成3组，第一组颈背部皮下注射商品化HVT疫苗(1羽份/只)，第二组颈背部皮下注射商品化CVI988疫苗(1羽份/只)，第三组接种等体积的CEF细胞作为阴性对照组，分别饲养于正压隔离器中。疫苗免疫5d后，将上述3组的实验鸡再每组随机分为2组，分别腹腔接种HN302或MDV超强毒株Md5(1000PFU/200μL/只)，具体分组情况见表2。
上述各组分别单独饲养于不同的正压隔离器中，逐日观察并记录各组实验鸡的发病与死亡情况，绘制存活曲线(图6)。同时剖检病死鸡，肉眼观察内脏肿瘤发生情况。至91d试验期结束，处死存活的全部实验鸡，剖检观察内脏肿瘤发生情况。最终的统计分析结果发现(表2)：CEF细胞阴性对照组中，HN302攻毒组的肿瘤发生率(70.27％)高于Md5攻毒组(69.44％)；HVT疫苗和CVI988疫苗免疫组中，HN302攻毒组的肿瘤发生率分别为61.11％和62.16％，均明显高于Md5攻毒组(31.43％和13.16％)。
表2 HN302和Md5感染MD疫苗免疫鸡的累积肿瘤发生率统计表
Figure BDA0003550384720000081
利用SPSS软件进行统计分析，比较各组发病率、死亡率及疫苗免疫保护指数(PI)。结果发现(表3)：CEF细胞阴性对照组中，HN302和Md5攻毒的发病率均为100％，Md5导致的死亡率为80.56％，高于HN302的64.86％；HVT疫苗免疫组中，HN302攻毒的死亡率为11.11％，低于Md5的22.86％，但HN302导致的发病率为66.67％，却高于Md5的45.71％；CVI988疫苗免疫组中，HN302攻毒的发病率和死亡率分别为72.97％和32.43％，均显著高于Md5攻毒组的发病率和死亡率(42.11％和28.95％)；HVT疫苗和CVI988疫苗对HN302的免疫保护指数分别为33.33％和27.03％，均明显低于对Md5攻毒的免疫保护指数(54.29％和59.89％)。
表3 HN302和Md5感染疫苗免疫鸡的累积发病率、死亡率及免疫保护指数
Figure BDA0003550384720000082
综上所述：HN302是一株MDV-1流行毒株，对鸡具有非常强的致病性和致瘤性，其毒力显著高于超强毒国际参考株Md5的毒力，可将其致病型定义为MDV特超强毒株vv+MDV。
该马立克病病毒HN302，已保藏于中国微生物菌种保藏管理委员会普通微生物中心，保藏编号为CGMCC NO.21929，保藏时间为2021年11月18日，保藏地址为北京市朝阳区北辰西路1号院3号，中国科学院微生物研究所。
实施例四：HN302的病毒全基因组测序与分析
提取HN302感染CEF细胞的基因组总DNA，送样至上海派森诺生物科技有限公司进行病毒全基因组测序分析。
首先采用全基因组鸟枪法(Whole genome shotgun，WGS)，构建HN302毒株的全基因组文库，然后利用第二代测序技术(Next generation sequencing，NGS)，基于IlluminaNovaSeq平台进行测序。去除带接头、低质量的数据reads，获得92.28％的高质量过滤数据之后，采用A5-MiSeq和SPAdes对过滤数据进行拼装构建contig；利用MUMmer软件确定contig间的位置关系，进行contigs间隙(gap)的填补；使用Pilon软件对结果进行校正，获得长度为175193bp的HN302病毒全基因组初始序列。
鉴于高通量测序长度有限，且MDV基因组内部通常存在大量互补和重复序列，因此上述获得的HN302病毒基因组初始序列仍存在一些gap，通过与NCBI GenBank数据库中已公布的MDV参考株的全基因组进行序列比对，设计引物对gag序列进行扩增和常规测序分析，验证和校正差异较大的gag基因序列，进一步拼接得到HN302毒株的病毒全基因组序列。
最终结果显示，HN302毒株的病毒基因组全长为175700bp，其核苷酸序列如SEQ IDNO.1所示。
应用例一、HN302Δmeq基因缺失疫苗候选毒株的构建及鉴定
1、HN302毒株meq基因的编辑与分析
人工合成表4列示的靶向MDV-1meq基因5’端和3’端的gRNA oligo序列(SEQ IDNO.4～SEQ ID NO.7)，复性形成双链，然后克隆至pX459v2.0质粒中，构建gRNA表达质粒pX459-meq-gRN和pX459-meq-gRC(分别缩略为gRN和gRC)。
表4靶向meq基因的gRNA oligo序列表
Oligo名称 序列(5’-3’)
meq-gRN-F <u>CACC</u>GTCGACCCGAGAGAAAGATCG(SEQ ID NO.4)
meq-gRN-R <u>AAAC</u>CGATCTTTCTCTCGGGTCGAC(SEQ ID NO.5)
meq-gRC-F <u>CACC</u>GTACTCAGTCTACGGTCTGG(SEQ ID NO.6)
meq-gRC-R <u>AAAC</u>CCAGACCGTAGACTGAGTAC(SEQ ID NO.7)
注：下划线标示Bbs I酶切位点。
按照Trans IT-X2TMDynamic Delivery System试剂说明书，将上述质粒共转染CEF单层细胞，置38.5℃、5％CO2培养箱培养24h，然后接种HN302，同时以未转染gRNA质粒但接种HN302的CEF作为阴性对照，以既未转染gRNA质粒也未接种HN302的CEF作为空白对照。接毒48h后，胰酶消化细胞，离心收集细胞并提取DNA进行PCR检测，分析gRNA质粒组合对meq基因的编辑效果。
PCR扩增引物对为：meq-F和meq-R(SEQ ID NO.2和SEQ ID NO.3)。PCR反应体系为：2×EasyTaq PCR SuperMix(+dye)10μL，10μM的上下游引物各0.5μL，10ng/μL的待检样品DNA模板1μL，灭菌超纯水7.5μL。PCR反应程序为：94℃预变性4min；94℃变性30s，58℃退火30s，72℃延伸1min，进行30个循环；72℃延伸5min；4℃保温至取出。反应结束后各取5μLPCR产物，用1％(w/v)琼脂糖凝胶电泳(150V，300mA，30min)进行分析鉴定。
电泳结果显示：CEF细胞空白对照组未扩增出任何条带；HN302感染的阴性对照组CEF细胞样品只扩增出1020bp大小的特异性meq基因野生型条带；而gRN和gRC质粒共转染并感染HN302的CEF细胞样品中，除了扩增出1020bp大小的特异性meq基因阳性条带外，还扩增出大小为100bp的预期基因编辑小条带(图7A)。
2、HN302Δmeq基因编辑缺失毒株的鉴定
将上述100bp大小的基因编辑小条带切胶回收并纯化、连接pMD19-T载体后进行测序，并与HN302毒株进行对比，结果显示：pX459-meq-gRN和pX459-meq-gRC质粒组合对meq基因进行了有效编辑，双链裂口(DSB)精确发生于2个gRNA的PAM序列内侧2～3个碱基处，产生的基因突变与预期完全相符(图7B和图7C中HN302Δmeq)。
3、HN302Δmeq基因编辑缺失毒株的纯化
将上述经PCR扩增及测序确认已发生meq基因编辑的HN302感染CEF细胞样品，用有线稀释法分别以不同剂量转接6孔板CEF单层细胞，38.5℃、5％CO2培养箱培养3～5d后出现病毒噬斑，显微镜下随机挑取72个病毒单噬斑转接至24孔板CEF单层细胞中，子代病毒继续培养48h后消化细胞，取样离心收集细胞提取DNA，按照上述PCR方法进行检测。
PCR检测阳性的细胞孔，同上进行第二轮病毒单噬斑克隆纯化。经过2轮克隆纯化、PCR鉴定均为编辑阳性的病毒噬斑，再次进行测序分析，同时扩大培养，命名为HN302△meq，保种冻存于液氮中。
将阳性编辑的毒株连续传代，分别收集第5、10和15代病毒样品，进行PCR分析检测基因编辑的稳定性。
结果显示：HN302 meq基因编辑缺失毒株HN302△meq感染细胞DNA中，PCR只能扩增出100bp大小的突变型meq基因编辑产物，其被编辑的基因序列与此前测序分析结果完全相同；不同代次的HN302△meq子代病毒样品中，均只能扩增出大小为100bp的突变型meq基因产物，表明HN302△meq基因编辑缺失毒株的稳定性良好，未发生回复突变(图7D)。
4、HN302Δmeq基因编辑缺失毒株的IFA鉴定
将HN302和HN302Δmeq毒株分别接种48孔板的CEF单层细胞，38.5℃、5％CO2培养箱培养3d，用预冷的甲醇/丙酮(v:v＝1:1)溶液固定，200μL/孔，室温10min；用含0.05％(v/v)Tween-20的PBS溶液(PBST)洗3遍，加入含5％(w/v)脱脂奶的PBST封闭，200μL/孔，37℃、30min；PBST洗3遍，加入1:5000稀释的MDV-MEQ单抗孵育，100μL/孔、37℃，30min；PBST洗3遍，Dylight 488Goat Anti-Mouse IgG(1:1000)稀释液孵育，100μL/孔，37℃、30min；PBST洗3遍，荧光显微镜下观察。
结果显示：HN302和HN302Δmeq感染的CEF细胞均可形成形态相似的MDV病毒噬斑，用MDV-MEQ单抗孵育染色时，绿色荧光病毒噬斑仅出现在HN302感染的CEF细胞中，而在HN302Δmeq感染的CEF细胞中未观察到特异性绿色荧光染色的病毒噬斑(图8)，表面HN302Δmeq的meq基因被完全编辑并缺失，不再表达MEQ蛋白。
综上所述，本发明以HN302为亲本毒株成功构建了meq单基因完全编辑缺失的MDV毒株HN302Δmeq。鉴于国内外已有多个MDV meq基因缺失疫苗候选毒株的研究报道，因此本发明构建和鉴定的HN302Δmeq毒株可作为MDV单基因缺失疫苗候选毒株，用于后续MD新型疫苗的开发和利用。
应用例二、HN302ΔM11基因缺失疫苗候选毒株的构建及鉴定
1、HN302毒株miR-M11的基因编辑
人工合成表5列示的靶向MDV-1编码的miR-M11-5p/3p(miR-M11)基因5’端和3’端的gRNA oligo序列(SEQ ID NO.8～SEQ ID NO.11)，复性形成双链，然后克隆至pX459v2.0质粒中，构建gRNA表达质粒pX459-miR-M11-gR3和pX459-miR-M11-gR6(分别缩略为gR3和gR6)。
表5用于miR-M11基因的gRNA oligo序列表
oligo名称 序列(5’-3’)
miR-M11-gR3-F <u>CACC</u>TCTTCCGAGTCTAAGCTACA(SEQ ID NO.8)
miR-M11-gR3-R <u>AAAC</u>TGTAGCTTAGACTCGGAAGA(SEQ ID NO.9)
miR-M11-gR6-F <u>CACC</u>GATATGGACATCGCACATTA(SEQ ID NO.10)
miR-M11-gR6-R <u>AAAC</u>TAATGTGCGATGTCCATATC(SEQ ID NO.11)
注：下划线标示Bbs I酶切位点。
根据Trans IT-X2TM Dynamic Delivery System试剂说明书，将上述质粒共转染CEF单层细胞，置38.5℃、5％CO2培养箱培养24h后，接种HN302感染细胞；同时以未转染gRNA质粒但感染HN302的CEF细胞作为阴性对照，以既未转染gRNA质粒又未感染HN302的CEF细胞作为空白对照。接毒48h后，胰酶消化离心取集细胞，提取DNA进行PCR检测，分析gRNA组合对miR-M11基因的编辑效果。
PCR扩增引物为Mid5F-135890 5’-TCCGCATTGTGACTCTCAGCAG-3’(SEQ ID NO.12)；
Mid3R-137024 5’-ACATCGTAGAGAAAGCATAAGG-3’(SEQ ID NO.13)。
PCR反应体系包括：2×EasyTaq PCR SuperMix(+dye)10μL，10μM的引物各0.5μL，10ng/μL的待检样品DNA模板1μL以及灭菌超纯水7.5μL。PCR反应程序为：94℃预变性4min；94℃变性30s，58℃退火30s，72℃延伸1min，进行30个循环；72℃延伸5min；4℃保温至取出。PCR结束后用1％(w/v)琼脂糖凝胶电泳(150V，300mA，30min)进行分析鉴定。
电泳结果显示：CEF细胞空白对照组未扩增出任何条带；HN302感染的CEF细胞阴性对照样品只扩增出1135bp大小的特异性miR-M11基因野生型条带；gRNA质粒组合共转染并感染HN302的CEF细胞样品中，除了扩增出1135bp大小的特异性miR-M11基因阳性条带外，还扩增出大小为841bp的预期基因编辑小条带(图9A)。
2、HN302毒株miR-M11基因编辑的鉴定
将上述符合基因编辑预期大小即841bp的PCR扩增产物小条带切胶回收、纯化并连接pMD19-T载体后进行基因克隆和测序，并与HN302毒株进行对比，结果显示：gR3/gR6质粒组合对miR-M11基因进行了有效编辑，双链裂口(DSB)精确发生于2个gRNA的PAM序列内侧3～4个碱基处，产生的基因突变与预期完全相符(图9B和图9C中HN302ΔM11)。
3、HN302ΔM11基因编辑缺失毒株的克隆和纯化
将上述确认已发生miR-M11基因编辑的HN302感染细胞样品，以有限稀释法用不同剂量转接至6孔板CEF单层细胞，38.5℃、5％CO2培养箱培养3～5d，待观察出现病毒噬斑后，随机挑取72个单噬斑转接至24孔板CEF单层细胞中，子代病毒继续培养48h，然后消化细胞取样提取DNA，按上述PCR方法进行检测。挑选PCR检测阳性孔细胞，同上进行第二轮病毒单噬斑纯化。经过连续两轮的克隆和纯化、且PCR鉴定均为阳性编辑的病毒单噬斑，再次进行测序分析，同时扩大培养，命名为HN302△M11，保种冻存于液氮中。
将最后一轮挑选的阳性编辑毒株连续传代15次，分别收集第1、2、3、4、5、10、15代的病毒样品，提取病毒感染细胞总DNA进行PCR分析，检测miR-M11基因编辑缺失毒株的稳定性。
结果显示：HN302的miR-M11基因编辑缺失毒株HN302△M11中，只能扩增出841bp大小的突变型miR-M11基因编辑产物，且其测序结果与初始编辑产物的测序分析结果完全一致。同时，经连续传代的不同代次病毒样品中，均只能扩增出841bp大小的突变型miR-M11基因编辑产物，表明HN302△M11毒株的基因编辑稳定性良好，未发生回复突变(图9D)。
4、HN302△M11基因编辑缺失毒株的鉴定
将HN302和HN302ΔM11毒株分别接种6孔板CEF单层细胞，置38.5℃、5％CO2培养箱中培养3～5d，观察出现病毒噬斑后用胰蛋白酶消化细胞，离心收集细胞提取总RNA。利用TaqManTM MicroRNA Reverse Transcription Kit反转录试剂盒制备cDNA。以上述cDNA为模板，分别用ThermoFisher公司提供的Taqman探针，通过RT-qPCR法测定6个病毒miRNA基因(miR-M11-5p、miR-M11-3p、miR-M31-3p、miR-M1-5p、miR-M4-5p和miR-M13-3p)的相对表达水平。
结果显示：以miR-M13-3p为内参进行分析，发现亲本毒株HN302编码的上述miRNA均能正常表达；HN302ΔM11毒株感染的CEF细胞中miR-M31-3p、miR-M1-5p和miR-M4-5p均正常表达，但未检测到miR-M11-5p和miR-M11-3p的表达(图10)，说明HN302ΔM11的病毒基因组中miR-M11基因确实已被完全编辑缺失。
5、HN302ΔM11基因编辑缺失毒株增殖曲线的测定
将HN302和HN302ΔM11毒株分别以100PFU/孔感染6孔板CEF单层细胞，接毒后24h、48h、72h、96h和120h分别收集细胞取样，利用血液/细胞/组织基因组DNA 提取试剂盒提取总DNA，利用SYBR GreenⅠqPCR方法测定两个毒株在感染后不同时间点的MDV meq、gB和鸡内参基因OVO的拷贝数。分别计算每106个CEF细胞中以meq基因为参照和以gB基因为参照的病毒基因组拷贝数，并绘制病毒增殖曲线(图11A和图11B)。
结果显示：在病毒感染后24h～120h，两个毒株的病毒含量均呈现持续上升趋势；在96h和120h两个时间点，HN302ΔM11的增殖水平显著高于亲本毒株HN302(图11)，说明miR-M11的编辑缺失增强了HN302病毒的体外复制能力。
综上所述，本发明成功构建了HN302的miR-M11基因编辑缺失的MDV毒株。鉴于本发明证实的miR-M11基因的编辑缺失可显著增加MDV的体外复制水平和增殖速度，在疫苗研发中具有极大的利用价值，因此本发明构建的HN302ΔM11可作为MDV单基因缺失疫苗候选毒株，用于后续MD新型疫苗的开发和利用。
以MDV特超强毒株HN302为亲本毒株，利用上述技术路线和方法还可以构建一系列的MDV单基因、双基因或多基因缺失疫苗候选毒株，如LAT-miRs基因缺失的HN302ΔLAT等单基因缺失候选毒株，meq基因和miR-M11或LAT-miRs基因缺失的双基因缺失候选毒株HN302ΔmeqΔM11和HN302ΔmeqΔLAT，以及meq基因、miR-M11和LAT-miRs基因同时缺失的多基因缺失候选毒株HN302ΔmeqΔM11ΔLAT等，本发明不再一一列举。
本发明分离鉴定的MDV特超强毒株HN302，不仅可以为研究我国近年MDV流行毒株的毒力进化和遗传规律提供重要的实验材料，而且为利用该毒株研究各种类型的MDV疫苗候选毒株、创制具有自主知识产权的新一代MD高效疫苗提供关键核心材料。
序列表
<110> 河南省农业科学院
<120> 一株马立克病病毒特超强毒株及其基因缺失毒株的构建和应用
<130> 动物病毒学研究
<160> 13
<170> SIPOSequenceListing 1.0
<210> 1
<211> 175700
<212> DNA
<213> 人工序列()
<400> 1
accctaaccc taaccctaac cctaacccct caaattttca ccccccccca cccccatcca 60
aaataagcca aatataatgt agaggatggg agaatccggg ggcgataaga cactttccca 120
ctcatactga cgatgtctta accgtgaacc tagtctcgat cccgagctca aaggacggaa 180
atccacactg gaaccggcac ataccacctg tgatgtgacg caaacttgga ttatgcaagt 240
ggtgactccg tggtgtgaaa ttagaccccc cctgtttctc gaccccccac cctaacccta 300
accctaaccc taaccctaac cctaaccccc aaaaacctct cgcggccgac aggcagttgt 360
acacctgcct gcactactac atccggtccg tagaccacat ccctgctcca tccaataact 420
cgaacgctct tcctataggt agatacagga catgttttaa cgaggttctg cgctaaatcc 480
agggcgggaa agctcagccc gcatctcgca gcccccggat ccgatcccgc agaccccggc 540
ccacaggaag gggcggggca cgtgcatggg gcgtggcggg agatgaatga ccgcggagtt 600
ccaaactccc gcaccggccc ctctctgctc gctctcctcc ccgccgccaa tagctacgcg 660
gcagcgtaca gcccggccaa taggcgcgcg gtgggcgtag gcggaggaag ctacaagagc 720
cccacgcggg gttcccccgg cacacgtggc gggtggaagg ctccgctgtg tctaacccta 780
atcggaggta ttgatggtac tgtcgccgcg ctccctccgc ccgctgttta ctcgctgact 840
ttcagcgggc taggggagcc gccccagggg gcgccgcggc ggggaggggg tggggcggac 900
gcgggagaaa ggaccgaaag gggctccacg gcaaacaaaa aaaaaaaacg tcagcgaggg 960
gtcctctcgc ccccatccgc cctggggtcc tcgcccgcag gccgcggtcg gccggcaccc 1020
gccattgccg ccgcgaagag ttcgcctctg tcagcctcgg cggcgcccgg gagatgcggc 1080
gcgcggcccc gcgcccccag cagagcaaca cgggagcggc gcccccgggg caacccccgc 1140
gcccccctgc gccgtggggc gcgcggacgg cgtcgctccc acacgcgcgg ccccgcgcgc 1200
acgaccgttg gagccgttga gccgcgcgcg gggctctgtg agtagaccga acgggccccc 1260
cgcggaggtg ggcgctcgag cccggtccct gcgcaggtgg tgcccgctgg gcgccgctcg 1320
gggctaccgg ggtccgtccg cggccgtgcc gggcgcccag gcgccgagtc ctggcctgga 1380
cgtgtggcgg tgcgcagcgc ggagccctgt cccggcagga gccgtcctct gcctcggcac 1440
gctccgcaat aagcgtgggc acacgtgtgg gccgtgcagg gcatgagcgt gcacaaagac 1500
gtggccctgg ggcttgggct gagcgcagtg cgatgccccc gggtcatcac ccgtcccgca 1560
gatccccgtg cacggggtca gtgccatctt gtggtctcgg ctttcttttt tccccctttt 1620
gcacgaagag tcagtgaact tggggtactt aatcgtgctt taattgcgcg atggagaacc 1680
gttgctagaa tatgtgggga tagagaagtc cgataccctc agaaatgtgc gagtcctgcg 1740
ggtagaatcg gcgcagcact gaataaaccc gcggggccct aaaacctctc gcggccgaca 1800
gacagttgta cacctgcctg cattactaca tccagttcgt agaccgtatc cctgctccat 1860
ccaatagcta cattatcgat atatgtacga ggagtcaaaa tcggaaaaaa aagtgccttc 1920
ttttaattac aggaggtagc aattaatcaa agacagatat gggaaccaat agtaggaggt 1980
gtgggctcaa ttgtgttttt taccggtccc acggtcgatt tgccaccatc ttctccaacc 2040
atcagatttt ccttccttgt gcgatgctgt cgttctagtt ttttaataaa ctgctgtacc 2100
caaggcgcct cagggtccac acataccttc ctgttcttct tgagagcaaa gctacaaaag 2160
ggaaaacctt aaccaaatta gctttacagc cagacactac acctaagatg acaaccccat 2220
attttggcca agtaatagag cttacttaca taatttcagt cctcctgcag tgtatactcg 2280
gtggtatcac gtcaacagcg ataataggcc ccaagccagt aggccgatta gtgactttca 2340
cgcacttgca cctcttgtcg acagcgagac tctccagtga tatgcctaca ttattaagag 2400
catgcattta tcagaacaac accatccccc gtgctacctt tccttatacc accattgctg 2460
cacatgccag agacgaaacc cctcagcttt tacgagtact ggttacatca gtatagcgta 2520
ttccacaacc tccagtctag agttctcttc ccctacttac catttccagg caacaaatag 2580
atctgtacta tgaatagaac caatactagc aacgacgcct gcatttttgc cgccccaact 2640
gctcatcaaa cccacacccc ctgcattata tatccatgga accgtacccg taatgcctcg 2700
ggcgatttcc ctgttattgg gtctccaaca acacgtgata ttggagaccc ccaacttaaa 2760
attccacgac cgtgagatgc attttgttta ttgaaaattt ccattcgatg gggcataaac 2820
tatagcatcg aaacactaaa atgaacagga gtttgcatca aaaggtgata atactggaac 2880
acaagactat gaggaccctt aaatgtatat gagaaaattc ccacgacccc tgcatagcag 2940
aaaaccagga ccacaataaa ttttgcagta cgcatgcgcc ctctacacac gacccgcatg 3000
cgcagaccac ttactgcagt acgcatgcgc cctctacaca caaaacgcat gcgcagtcca 3060
aaacgcatgc gcagaccgct tacggcagta cgcatgcgcc ctctacacac aaaacgcatg 3120
cgcagaccaa ttacccaaaa caaacatgcg ccgtaagtat ggttatctgc gcatgcctgg 3180
ttttcgacac acgcgcatgc gcagatacac tccaccatac gcatgcgcgt catgcataac 3240
tggcgcatgc gtgaacgcct tacccgaacc agccctgcgc gcttgcgcta tatacgccct 3300
gcgcactcat cgcgcatgcg cacagacgtt caaataatgg cggacatttc cgtcaacaaa 3360
cgcactaagg taaaaaaaaa cccacgaacc gttagttttt aggagctacg atttaatttt 3420
catgctctgc tttatcaaga ctcgaaatgc gttacagctt ccccccgtac cggcaccgac 3480
agttctttac gtaagccctt cccgttcact ctttcacgcg cggcactatc ggtacaacag 3540
tggcacacat caaacaaagt aaaaggggaa gggaattgaa tttctacaaa agatctaaat 3600
tttacgtaat ggatcccgtc ccgatcgtcc cctcacacgt ggcactgccg cgtaaacaat 3660
gccacatcgt agagaaagca taagggggag gccatcggga gattatcccg agaattcaaa 3720
ctattcttgt aatgtcgtac gagcctcgtt ccgttcgctc tttcatgcgc agcattaccg 3780
gtgtaaatgt aataatgccg cacagtgaac aagcaaaagg ggaagagagt ctccggatag 3840
ccgttacaat ccagtaacga cttaacgcag attactcctg cataagcgtc tctgcgatga 3900
ggtattttcc atatgttcct ggaggtccgt gcctgtatat tcgttaatgt cgacatctgc 3960
ctatgtgcct gtgtatcggt gcataggagt atgtctgtgc atccctgtat atattatctg 4020
tgcatatttg cataattcat aaacgaatat ttaattacag tagtgttgcg cgagccccga 4080
tccattgatc tgctcacgac tgtagcactt agaatcgcac agtgcacagc cagtgagctg 4140
gccacaggag agggacatag gcctgattgc tgggacgcgg atgagagatc aatcgtgttg 4200
ttccttacga taacctaatc agcaccaccg aattatacga gactgcatta actcacatct 4260
gctaaaggtt tcgcttattc cttttacatc cgaatgtcca tcctgttatc tttaatattc 4320
cttaatgtgc gatgtccata tcccttctaa aaaaaaaaca gccaggcata gtttttgagc 4380
ctggaaaact taccgcaggc ttcatagaag ccatatcccg aataatactc catatacccc 4440
cccctcccct tccccaaccg ttctgtatag aacgagaatt tgccatttaa gcagtctggg 4500
gccgagagat gttgccccag aagttttcca catagctaag tttatctcat acttcggaac 4560
tcctggagcc aacaaatccc ctgaccatgt aactcaaaat agttcttccg agtctaagct 4620
acacggtaag gaaaatttgt taccccagag gattttttta tgtcagtaaa tcgataaata 4680
atgcctttaa ccctttcctt tatgttgatc ttcccgaaac tatgaaaact attatatata 4740
actaggggag aagaaacatg gggcatagac gatgtgctgc tgagagtcac aatgcggatc 4800
atcagggtct cccgtcacct ggaaaccacc agaccgtaga ctgagtatcc gagggaaact 4860
gaatataaat ctggcccgaa tacaaggaat cctgttcggg atcctcggta agacgagcat 4920
aaagcctctc cggctccgga gccggatgtg ggggagatgg ggtaaaaagg ggagcctggc 4980
caacaggaca aagctgagcg taaaccgtcc ccggcgatgg aggggtacac ggctcggtaa 5040
caggacacaa tgcagggaag atgccctccg gagatggagg ctggggaggg cagaagaggg 5100
aatggggagt acagatggga ggtggtgggg tcgagcagag ctgggcgcaa agctcctccg 5160
catcgggagg agcgggggta cagataggag gttggagggg ggaaggcccc ggagcgtaga 5220
taatatgggg agtagagatg ggaggtggtg gggtcgagca gagctgggcg caaagttcct 5280
ccgtatcggg agtagggggg gtacagatag gaggttggga accggagcaa tgtggagcgt 5340
taggttcatc cggtgaggga ggtggaggag tgcaaatggg aggttcagga acgggatcgt 5400
gcggggtggt aagcagtcca agggtcaccg ttaggggtac cgccataggg caaactggct 5460
catgacaagc caactgtgca cgcagggacg tgcactcagt ccttagatct cgaatttcct 5520
tacgtaggtg ttcattggcc ctctgcagct cttcacatgc ttcatggagt ttgtctacat 5580
agtacgtctg ctccctgcgt cttctccgag cggcgtcacg attccttttt ctcctccttt 5640
ccagcttctg tttctcctcc tcagataggc cgtcagggaa ggggtgtttg gaggggctgt 5700
tggggatgtc gtgacttttc ctttttttcc gtctcgaagt cgacccgaga gaaagatcga 5760
ggggggacgg atcgtcagcg ggactgtagg gcatagcgcc cggctctggc tcctgagaca 5820
tctctttaca cctgtaccgt gcccgccttc tccctggtat acacctgcaa gagacgcctg 5880
cctaggaatc agtgtgcgga atttattctt aacattccag caccaacctc cccgaaccaa 5940
aataataatt aaaaaagcaa cacccacaga cccgaaagta ttgaagaatt acacgttcgc 6000
gaacggtcac aattcacctg tcattttata aaggagcaat agtttattta agaggtaggt 6060
ataaatcgat catttccccc ccccgtctcc gtatcactcc cgaaccatta gatatcagtc 6120
gatccagccc cccacgtcat gcatgactat cgtctttata tcaccgaatt cggttattcc 6180
aaatccgatt caatattaca tcacttcaac ggtgtataga cgttctacga tggttttcca 6240
gcgatcattt cccccagaaa ggtcatgctg tcagaaccat tcgtggtcac cgaacgaagg 6300
gttccgatac agcattaaac ttcacagggg acattcaaaa caagcccaga gccgtcacgt 6360
ggaacacgtc tcgagtcgat cgctcccctc aagaaagcta ttctgcggca gtccgttcca 6420
agaccttaca aacggactac cgggcagaat acaactttct tttaggagaa tatacaaagt 6480
acaatgcggc cgtcggatcg ctctcgcgat acgcggtgtc acgaagaccg atacactaca 6540
tacaacttaa aaatgtgaac ccccccagca gattctattt ctagcgggag aggtttcaca 6600
ttttcatgcc gcctgtagtg aatcctgatc aagaacaatg cagacgacag gtactaaatt 6660
cgtcagtacg tggccacagt aagtctggct catatcatcg ctaaggactt ttggcctcgc 6720
gtacgatcgg ccactcggat cagaaccctc cgtattatgc aaacctttgg acatttacat 6780
tatacggagg gccttgatcg gcgagggcat tatcccctct ccattaatta taccgccagg 6840
ccttgatcat tttcccatcc tgctcaccca ccgtcccata tctcaaacaa cgcgaatttg 6900
taacacgggg gggggggggg gaagaaaata atgtatcgat tgtatttatc gcaccaacta 6960
ttcttttatc ctaacaacaa ctatgtctga aaccctgaag atgtttcaat accaccacaa 7020
acagtagacg accacgatac acacgtatgt attttaaacc gtgtcaatgt gatcgcatac 7080
ggttcatgac agttgataaa cttttaaaag gctcgagtcc gtctcccccc tctttttttt 7140
tcacgttctc ctaatattgg ttacaaccga ctgctcacac acatacaacc cccctccccc 7200
acgatgctca ttagccttca aaaattatat tttgaagtat gtgagtcggg gcactttttc 7260
ctgccctcgg agtttacaac gtacgataca gtgaactccg gggggaagga gaaaaaccgc 7320
tccggcacaa attatatatc cgaatgagaa ttatctcgtg catcgcccgc gtacggaaat 7380
gtatatgagt agactagaaa aagtttaaaa tctactttcc cattttgttt gacccacttc 7440
attagatcta cccgatatgt tacactcccg gagatcaggt ctcttagtta tccgggaatg 7500
attaccttac ccgcactttg gttctaaatg tcacgatcga aaagccggct ggtagaggga 7560
tcgggcgaaa agatcgggga gcggacggac tgagccttaa gtagaataac tggcgcgcag 7620
ccagatcctg tatgaaaggt atgtattaga aattcgattg gccgaacagg gcaattcgcg 7680
cacgattatg cgtaatcaag cccacagatc gcaccttcaa ccgataagag tctctagatg 7740
acaaatcgac agttagttgg aaagtgttcg ggggcggtaa aatttccagg gcctctcgac 7800
ataaaggcct ctaaagtata attcgctggt tctgctaatt aggaagagcg gttctgagta 7860
atcgtcacac cgatcgcata tttatgctga ggcgaggggt aatgagatga taaatcagca 7920
cttaagaaag ggcatctgtc tatcagggcc ccagacatca aaggcactgc actataaggt 7980
gattcactta agctaaaatt ccgggcatca gctatgagta agcaatatca gttatcaaaa 8040
atttctcatg ggaacagcga cttaaaaaaa aacttataat aaaaggaaat accttcaata 8100
cccaatgacg ttataaacaa ttccgtataa atcctgagga gctgccgcaa aaaaaactac 8160
cccatttcgc gccattggaa cgtatagaat aacaacaaca aaaataaaaa cgcagtcggc 8220
acggtttcat aattccagga tcaaacccgg ccgaacgctc tcgaaatata acacaccccc 8280
tcccccgccg ctactggtcc ggaaatcatt gagtttagtg gcaaacgaca aacagacaaa 8340
aattgtagat gccgccagct agttgagaag cgcacagaac atatatcgag acgcatgaag 8400
caaccgacac cgcaagttaa tttacggcgg ttactgtaca tttgcagtaa ctttttttaa 8460
ccttgatcgt accgtacgcg aaggggagta tacgaaagat aaaatgaaca cgcatacagt 8520
gaaccaatat ccgtaacctt ttaatgctcg accgatttac aggatgaggc tgaaaaatat 8580
acatacattc aaaataatta gaaaaacaaa gacaatgaac gtccccgcta cacgtccgcg 8640
ttcgtctcgg cgaccgccgt acttccgcaa tcgtttacag aagcgtcata tccgttctat 8700
ttccgcaaac aaagactttg agacaggatt tccgtgttgt cgtgtccggt catacattct 8760
atgtaaacaa ggaagttatc ccctttgctt ccgtattatc gataatcggc tccgatcccg 8820
attccgcgga ccaagcattg gctgcaaact atatcggaat gcgccagacc ttctttgcgc 8880
gtctccagac acttctgcga tcgcagacga agaagcctga cgtaggtatg atttttccta 8940
ttacctatat ttcccaccgc cgaatgatac aaatggggcg agatacttct ttttagagtt 9000
aacagttcca tttttcttac atgctcaaac ctaaacatga cgtcacaccg aacaggcgga 9060
cggcaaactt tcgccatgtg tactgcttgt atgctacaac ggccaatcgt gttccacatg 9120
catgcgactg catgtttagg tctcacccct ctcgaaccct acaacatctc cgctccatgt 9180
gatccgaagg gagatcgaag atcgtagact ctctacatac accggcctca atataccacg 9240
accgacagag aaagttgggg aagggtaagc gaatcgcata cacacttttc cggtagatgt 9300
caatgtgcaa aaaaaaagcc tcgagaaatt gagatgccaa ttattcctgc taattctagg 9360
tatactcaaa tttcataccg ttgaacttca ataaacagtg atctgtacga agcattacat 9420
tcttacagac ttatatgttc gtgcgtatat acagacgtat tctaagaata cataactata 9480
cgcagcgtct ttctgcagtt atctaatgcg tagctttgat aatgtgcaaa cagcgactca 9540
ttatcccgcc tagctactat ttatactgga ttcagagggt cgattccact tctttctctt 9600
gtggaatctc tgccagaacc tcacagctct cgtttctact acgccatgtt acaaagttgg 9660
aaattaagga gcgagccctc tcacaaaaac ttctgatgcg atcaccaaaa cttgatgttc 9720
cgttcctagt tgtcgcagta tccgtttcga gatggaaagt gggtccgcag tcaatgcacc 9780
cggggtctgc aacgatatca cagctgtaat caacacggat ggtaggtaca ccggcacact 9840
ttgttagtag aacttaatag tttttttttt tcagtcctgc ttcatataca cgttcttaat 9900
tctcactcac aaaatccaac aaagtagata tgttcttcct gaggcataga aaagtccaca 9960
ttgccaccac aaatagatca cgcatggata tttacctctg cgaaaattgg gatcccccaa 10020
agcataatcc cggatgatga atcgagctcc gttcgaagca gtgattattc tttctggggg 10080
ggcactacct gggtaaccaa acctcatttt ttttttgagg ggagagtgaa attcaagctt 10140
cccgacacac ttactaagtc aggtagagac cccaaccaaa atcgggtgta gggaaagtcc 10200
cagaatgaac ttgggattat atagattgca ggagtctctg caaacatggg gcgaagccac 10260
gagggaggag ttgtcgatga tgagacaaat ctactgtctc atgaaacata ccccttcccc 10320
cgcttcctat ctcagcagaa aaactcatat agccttccat actaccgtag tataaaaact 10380
atagataatc ccctcttctg agtctaacag tgacattacc tcataaaaaa aaacatatac 10440
acctgagtat gatcacgata cgatttattc tcagttgtta aggttcattg tgccaacatt 10500
ttcagacttt gccccctcag ctaaatcctt tgaagcaata ttatcgttgt tacgtcgtac 10560
attaatctca cctcattagt acacattcaa tcaacatgtt acatatctat agcctgatga 10620
tacatctcaa attaatccca cctcattagt acacattcaa tcaacatgtt acatatctat 10680
aacttgatta tatcagaggt gtcaacagct cttgtacaga catatccaat acaggcctcc 10740
tacacctgca gtctcaaaac tattatatca gcaatacaca ctcggtcatt ccatactaaa 10800
tcaaatctgt catggcatac cgttcccacc cagagccgtg tcaatcgaca actgagaagg 10860
gtttctttct gccgtagtat ttatcatgta caaagacgga agcgcgggga cgttgatgga 10920
ggagttgcaa acctgacgtc acaaaacagc tacgcagcaa aagcaggtaa agtataacct 10980
tctttctgcc gtagtattta tcatgtacaa agacggaagc gcggggacgt tgatggagga 11040
gttgcaaacc tgacgtcaca aaacagctac gcagcaaaag caggtaaagt ataaccataa 11100
tcgtgcaaca acgcccaaat agtttaaatg gtgcaattcg tcaataaatg aaagtttcat 11160
gtcgtgtatt tattgcatca tatcttaaca agggagatta aatcaaaaaa aaaaaagaga 11220
ttgctaggtc gaaagcacta ccgaagtcgc atttagccat gctccttata agacagtttt 11280
ttttgttttt tttggggggg gggggcaact cgtaaggctt cccgtcactc aaaggaatta 11340
ctggactcga atttaaggag atcctcgtaa ggtgtaatat aagggcacct aaaacagttt 11400
ctaatcgaaa gcgttaccga acttgtcttt aatgagaatc cctatgagaa agcgcttgaa 11460
tgtggaagta gacataaaaa cttgtttcgg cagatcgtaa gcattgccga actcacattt 11520
aataaggcga ggctcgtgtg aagaacccta gcaagggcag ttacagaaca tgctcgccga 11580
gcaccacccc cttgtggaag tagacataaa aacttgtttc ggcagatcgt aagcattgcc 11640
gaactcacat ttaataaggc gaggctcgtg tgaagaaccc tagcaagggc agttacagaa 11700
catgctcgcc gagcaccacc cccttattcc tccatagcac tttcatcgca ttttttttaa 11760
aatattaacg tctcaatcta tataggaagt aataccgaac tccaactaca tttaaaatcg 11820
acatactttc tcccacacat acatattttt ccatgtaatc aacattcgca gaataaacct 11880
tcccatttta atgatcgcgg tcctatattg tggaactgtc cccccaacaa aaaaaaaata 11940
tcggattata tcagcccatc ctttctacat tgcacgaccc agccgcgtcg ctcattcctc 12000
cgataaaaga ccataacatg agcaaatgag accatacaga aacgacaccc atgggtctgc 12060
ccagcaggct catcccgggt cgatgttgac ggtggtctgc ggtcccggat cgtcgggact 12120
gaccgacgaa ccgcttcatc accaaatatc gccgtaaata aaaaatcgcc gttctattaa 12180
ttgggatcct tttttttatt tgcttatcga atgctagtaa ttttattact tatttgatga 12240
agggagaaat tcagctcgtt cgtcgcctag cgtagcgttc cttacaggaa atatatcggg 12300
gatcggccgt gccattctga gagagcatcg cgaagagaga aggaacctcg caaccgccgc 12360
tcttttatac acaagagccg agccgccccc acatgtaccc ccaacactca agtgcgaatt 12420
tggggcggta catgtcacgt gataacatat cgccatatcc gattggctca cctcggcgtt 12480
cgcaccagag tccaataata taatataata taatatatta ttggttcgca gtgcgaacgc 12540
tgacgcgttc gcactgctca tttgcataca catcacgtga tagttcgagt aggcggtacg 12600
cccacccgta taagaatcgt aatttcttgt ggcctcgagt ggcggtgcga cttgctctcg 12660
tcggacggga ggcggcggta taggataaga gatcacaaaa aagcgagacc tggatcgaac 12720
ggcaacgtct cgtcccggtt gttaatcgtt tggaacttct tcgcctgatc ggtggtgtaa 12780
ccgtgtaggt atttttagtt tttatgtacc atttcggttg ctttattata tttcccaccc 12840
atcgtttttc tttataacat agtttgaccc tctcggcatc acagatggca ccctccctcc 12900
actcatgacc cacaaccgcg atttgtcttt catcttcaac ccacagccat ccttgtcttt 12960
ctgcccgcac cgcacgcttt gctcgtcccc gcgtgcaaga tcggcagggg gtgatggaat 13020
tcgaagcaga acacgaaggg ctgacggcgt cttgggtcgc ccccgctccc cagggtggaa 13080
aaggggcgga gggccgcgca ggggtcgccg acgaggcagg gcatgggaaa acagaagcgg 13140
aatgcgccga ggacggcgag aaatgcgggg acgccgagat gagcgctttg gatcgggtcc 13200
agagggacca tggggataag catacagaga gtacttcccg aaaacgcata gaagcgaaat 13260
atatggattt acttgtcgaa gctgaacggg aaaataaaaa tcttcgaaaa aaatataata 13320
tcatacttga cgttagcaca aaaatattag tgttcggaac atgtataatg tttgcaactg 13380
gaacgttgat tgggaaaggt acaaagatcc aagttcctgt ttgcaacagc actaatctag 13440
ctctggcctt tcttgcggga tttctgactc gacatgtttg atttatcatt gagtaattat 13500
agttgcgtct attcaccatt acattaggta gtcgtggttt gccacgacat taactataca 13560
ttgtttagta gaacaaacgc aggaaagatg tacaatgccg agtaaaagta ttgcggatca 13620
tcatgctggt tacggggtag cgctcgcaat tgtagcttta ttgttgatcc atggaactgc 13680
attggttatg gtgagtgttt tcatgtagtg attggtttct atatgttatt aatttttatt 13740
tacaaacgct ttcctattag atattttcag atattaaggt cggatcgcaa cctcaagatc 13800
taaaagacca gctttcatat ccgagtaatt atgacgcata tacctcgcat atttccggag 13860
ccgatcatgg acattcagaa atgtggactg atatcaatcc tccatctagg aaaccactcc 13920
atggcgattc ccttgatata aaaacaaatg aagaacatat tactttatca tcgcccagaa 13980
catctacaaa aacgacaaac gagaatgggc atgagaagga ttcaaaggat attaagtttt 14040
cattttctac gaatagacac cccatttctg tttcacctac tactgatatt gtttctattg 14100
cagtttcgca caataatcca atgggtgggg atacatggca agtttcaagg aatggtccaa 14160
acacagttca tgtaccaatc tatgggaaac ccattttacg attaaatgga gaagaattat 14220
ctactcagat tgctcatatg agtatgtggg atgaacttgc agggtcattt aaaacgtttg 14280
cagcgactgc agaaagcttc catatgataa ctacaaccca tttgtttaat aaaacgttgc 14340
ataaagacgt ttttttcgtc gtccatggat ggcatggaat tacaaatgac actcatatat 14400
ttttatctgc tgtaaggctt ctgacgcgta tgatgccaac atcatgtata atctaccttt 14460
catgggaatc ccagggtgca attggaacag ctgccgatgc catcctgttg gcccggcggg 14520
taaacattac acagttcttg tctgccatgc catctcaact gcgaatccat tgtatgggcc 14580
attccttggg atcatatgtc tgcggttcta tttgcagaca atatcatagt cttatgtcgg 14640
gaatatgtaa aggtatatta ggtataaatc cgtatgaagt gttattctca gcacctgatt 14700
tatatgcacg catgcatgta gataccatac gcttggacgc ggaatatgtt gcaatttttg 14760
ctacgacttc gcaatatttg agtacatccg attcagatgc cgatgaatat ataatagtca 14820
atgatgcagt ttttatgaat agcgtatgtg caaatcccta tgaatggaat atccacttat 14880
gtactacagg ttatggggaa ctaaaatcat gtgagagatt tggggctgcc aacgtaacca 14940
ctagtcctgg agtagtagaa gatggttccc aaatatgtct gcgaatgctt ccaataatcg 15000
cagtactgca atcactagat ctaaaatcct catacccttt gttacgtatt gcccctccag 15060
atgcgtccaa tgaagtaacg catttgccat caatttggaa tatttacgta gtaggtaaag 15120
attatagata ctctacatat gcaaaaaacg atagcttatg gtattcgagt gcaatatgcg 15180
caggagatac agggttttct ataccatcag tgtttactgt attcgctcct ccgagcatct 15240
ctcttagggt acgagctgcc gtacaacaga gcagcactat ttataagaac ataacaattt 15300
attccgcatt tttaaaaaat acgtcccgtt attatcccac cgttacgctc gaaacattag 15360
ggccaattct atcagcgtac gcttggagag ggcgcatgca taatagtagt tattatccgc 15420
tccctcttcc ggaacaggaa ataatggaat ataagtgcac gcatatagat cgaacctaca 15480
cctgcattcc taccgatctt atttatgcaa ctacggtctg gcgtcagata ttttcaatgg 15540
gacatatttt tcccgtgtat ccatccaaca attgcctgcc atatcgcccc actaatgcca 15600
ttatttggag acgccctgta ttagaaatag gagtgtggaa taacataaca gcatcatttc 15660
aacgtaacaa acaactgatg gctttaacat tcgaaaatca taatacagcc acaaatacga 15720
ccttgttaac gtttcatgat gtatgtcgtg aaagcaaaat cagatcggtt gtctacttcg 15780
agtatgattg gcttgagact tcgatgaaca ttaccgtcct gatacctggt ctatacacgc 15840
ttaggtggtt tttcccattt gagataattg agatgccagt aagagtatct tataataatt 15900
catttgctca agctctcaca acttcgcggg tatgaatcga ttcgataata aagtatgaca 15960
aatcacgtca gtgtcggttt tatttactat gatcaaaact gcaatatcat cttcgtattc 16020
gtcacttgcg aaatggcctg gtaattataa cattggggaa tgtatttaac agcactgaaa 16080
atgcaatttg aggagtgaga gattgtgaga aatgtcaact ctgagaaaga cgcatataat 16140
acattaattt tgggtcgacg gatggaaaat cgtgctatcg gcaatgagat acaaactcta 16200
gataacgatg ttatgcaaac atagttgcgt ttaaacctag gagtaataat gcaagttaat 16260
agacagctga agtccggccg gccttataca atacagattt tttctcatat ggaatgagca 16320
tgtaatatcg actcacaacg tatattccct taaaaggagt attccttaaa aggaataatc 16380
tcgcacaatc tatgcagaaa cagataatct agggtgtggg cggtgctttg tacttcctac 16440
gtcggatcag ttataaaaac gagaggttgg taacaaacag cttttgaaaa atgactagcg 16500
agagagctct tactctcgcg cctggtaaag tttcgacggc agatatttat gaagccgatt 16560
tcagtttccg tcgtgaattt gtacgccaaa ttttacaacg tgagtttata ttgtttgaaa 16620
tttcaatgta tattatcttt atcgtgacat tctgttataa aattatactt tttttattta 16680
ggattattcc caaggacctt gaccaccgtc aaagaaatag agggcgcaaa atgtcagcgt 16740
ccgcctaagg tggaattgtc gacacttcta cgtataatag cccaccatga agccccacac 16800
atttatgctc caggtcccca gctcccgaag tccacagcaa tcgttgatgg gttatgggta 16860
gcttgtcgag gtcttgctgc tgaatgcatg tttaccggag gaggaactat tgcattaata 16920
gaacgtctag cgacttcctg gctaacggcc ataagattga ttttatcctg gcatcccatt 16980
cacgctccca atcgtaatca agagcctctc gatagcttat gccgcgaagg tcgcgaatat 17040
attgtaatga tttctgggac ggttcaccca cgacatgcta catggccatt ttggcaagtg 17100
atgcggaaat gtttagattg gtgctgcgca tttcacccac ctgatgacca cagttgtgaa 17160
ttcggagcac cacgcattgg aatccggcta gagggcgaaa atcatttttt cgcaccaatt 17220
ttgggattgt attctgtagt aatgacatgg agtccaattt catgttaccg agaattccca 17280
atacgtcaaa attctaagga gcctgatccc caaccatcaa catcatccga acctgagcct 17340
cagccatcga catcgtctca tcgtaacatt cccgtagcac gtgtaagacc tcttgtcgct 17400
cagcaaaagg tacccaaaac tagacctttg gatacagaaa tacacaggcc cggaccaatt 17460
gcaatccaga acccaacaga tacggatgaa cctgaacttc gcttgaaccc gagaccacgc 17520
ccgggtcctt cggggcaaaa tacacgtcca aggactccca ctttggactt ggataccgtt 17580
gtcgttcgag atcacccagt aacacatcgt cgtccgcgtt ctcctagccc acctgaggaa 17640
gattatacta accaagatga aaatctctca tatactcccc aattaatcca ttcttcccca 17700
gatagtgaag ttgctgagga gatttatgct cagcccgacc cttggggtac acaagaactg 17760
ctattagcaa atcgtgaacg cactccagat gatcaaacag atattacgga tgatagcgca 17820
gactggtctg agggcgaaac acgtcgacca tcacatagtg aagttgggga acgtagattg 17880
tccagagaaa ataacagtga agatccaaac cgtagtcgga gccggagtcg atctagggag 17940
cgtaggcgaa gacggccacg agttaggcct gggcgtagga gtacggctac aactatacga 18000
gatcttgtgg ttcttgggat gtcgagttca gatgatgaat agcatttgtg tatatgttgt 18060
gtgattgcaa atccactgta tggttatata gtcagaattt aataaaatgt tcgaagttta 18120
caccttcacg tattgttatg ggtatttatg ggtgggcgag ggcgtgttac aaatattaat 18180
tttagagcct ttcacacatc ccaacagttt taatcggagc tgctcggtag catgaaaatt 18240
tatagagtac tcgtgcatct ttccttcgtg ctaggtatgt ttactaagac caatacggtt 18300
ctcgcatggt cgaaatacga cctggtacac ggctttatga gggtagcgaa cataagctcc 18360
attatgcggc tcgactgcct tccgaactta ttatcttcga acgcggggta tgccgcactt 18420
ccatcagacg atattcccac gggcattttt attaaggtca actgcagcat acccgaattc 18480
attctatggt atgaacaaaa agccatggca gcgtggatca atcctattat gggcactgtt 18540
ctaatgatga atgacgtttt gaaaagcgga ttggagaatt ctgtgaaggt gggacttctt 18600
acatttctaa aacggatagc tgaaaaagga cccaatggac ctcttagaaa tcgcggatcg 18660
ggttgcatca atttaattgc gcctgccgat atttcatgct atggctcaac tagacttgac 18720
aggtttaacc gagacttcga agatgatagt cggggaatgc catgtcgagc taaagcgatg 18780
cgccgaacca cctctggcag ccgacgagcc aatgcctaaa aaatgtcgta ggcctgcagg 18840
acctcccaaa ggttttatat cgacacgcgg tgatacatca ccttcatcgg ataataatca 18900
catacattca attcaatcct taacgaatgg agacagttgc gtacaaccgt gggatattat 18960
agcgaacgcg tataacatcc atgaaaattg gaaacaacta ctacttcccg aactgtgttg 19020
tcttagagga tcagaaatct tagcggagta tgagcgcaga gctattaccg aagaagtcta 19080
tccccccaaa atggatattt tcgcatggac caggtattgc gctccagagt ctgttaaagc 19140
agtaatcgta ggacaggacc cgtatgctaa cccgggtcaa gcgcacggct tggcgtttag 19200
cgttaaacaa ggagttgcca tccccccgag cttaaaaaat attttattgg cggtcaaagc 19260
atgctatcct tcagcagatc tgggaaatca tggatgtttg gaggcttgga gtaaacgcgg 19320
agttttattg ctaaattctg tcttaactgt caagagagga gaccctggat ctcaccattc 19380
ggtaggatgg cagttcttca tccgaaatat acttcggcga ctgtcatcga caacgcgtgg 19440
tatagtattt atgttatggg gagcgcaagc acaaaccatg tattttcaga ctgattatga 19500
cgaccgtcac ttggtactga aatacagcca tccatctccc ttatccagaa aaccgtttgc 19560
tacctgtaca catttcaaag aagccaacga ttttctcagt aagataggta gaggctgtat 19620
cgactggagc cttaccgcgt aagtgacggg atgtgtaatc attcacatgt acaaaagacc 19680
gggtcacaaa cacctatcga tatcaatcat aatggatacc aacacacctt ccgtattaac 19740
tgtgttagca agctggggtt ggaattgcgc atcatccagt ccggcaactc aatgcttaga 19800
gcgttccacg cagggatgcc tgcgagaagg gccctcagca caaggttgcg attattgcga 19860
accggtgaat gtggaaaacg gcccacctac gacgtttgtg aaaaatcagg atcacgcgaa 19920
aaatcaagaa tatacccatt ttgatactct atttatggtt tcctctatcg atgaattggg 19980
aagacgtcaa ctgactgata ctatacgaag agacttgaga cattcacttg ccaagtttac 20040
catcgcttgt acgaaaactt cttcattctc ttcatcatat gctacaagaa agggtcgtaa 20100
aaaaaagggc cctagaactc agccgagtaa caagagcttg caaatgttca tattatgtcg 20160
tagggcgcac gctaaacata ttcgagcaca attacaagcg gtaatccaag ctcgaaaacc 20220
taggaaatac tatactcggg ctatagatgg cagcacgcat ccagtagtac ccgtgtttgt 20280
atatgagttt gctgcaatag atactgtcag tctacatcga gacaacgtga tagtagattc 20340
ttctggttcg tgagtgcctc gcttgcatat aataatgttt gtagtctccg cgtctttggc 20400
atctgcctca gactatatgc ttttcttgaa tacgactagg caagctgttt acaaactgca 20460
gattatggct ccccctgaat ccagcaagca tattacgcag aagtccaaca gagtttcgaa 20520
aacaactatt tcgaaaacgg ctagtacatg aagatggtat acaggatgac gaagaattcg 20580
atatacattt gcttatttcg ctgtccaccc ataaccgaga tatggaactt aatgatacaa 20640
gtatgttata atagtataga tgaataaagt gagacttata atacttattg catagatgtg 20700
ttttattact tgccttttcc aggggtagtt tgtttattac ctacaagtat gttataatag 20760
tatagatgaa taaagtgaga cttataatac ttattgcata gatgtgtttt attatgtgcc 20820
ttgtacaggg gtagtttgtt accagcaagt aaaaaagttg gaactagatc agggataaat 20880
tttcacagat tccaggagac acgagtcttc cgtgaagccg tatggcatgg gtgatggata 20940
attgacgggg gaacactgtg aatcctccat ccgcaaatcc gcttcgcgaa gcgcttcgat 21000
tagaatatct tctccactta tatgaggaaa tttgtccagt atcgggggtg tgtgctcatg 21060
taaagtgtca gtcggatttg ccccgacata ttctatgaat ccaggaacgc ttttagacaa 21120
gacttgtgct gcttcgctat tctgttgagg gtcatccttt ctaggttctg ctactacagt 21180
gggatagaat tgtcgactac aattttgaac cagatgcaaa ttatcaacag ttttcgcaaa 21240
cgtatcatgt ctcccatata tggtaatggt catatatatc gagcttccca tccacataat 21300
agttaagacg ccgccagaat tgttatacac gtacgcatct gtccccatta cagtacatgt 21360
agtaaatggt atgacgcata gcgattcggg cagagatgag agcgatgtag tatgatactc 21420
ggatccactt tcatcggcgc gtaggagata agaacatatg tccgttccgc tgtcgacaac 21480
aatgagtgta cctaccggtc ctcgttgtat gataaaattc gatgatggaa tatggtcaca 21540
tctagatagc ttgccgacgg caatcgaacg tgttccagct tcacacgagc aaataatttg 21600
ctcgtagggt ggcattgtcc atgctggtga tgctttgata ttttccagtg tatacgcgat 21660
aaaggtagat cccataatat gcactagtag aatatactta tataggaccc aacccttcgc 21720
cagccgtatc aatagacaat atgaacctta ggatctctaa gagctgctaa taaatgttca 21780
ctaatattgt tgtcatccct cgagtgtgtt tcccgaagtg gattaatatt cattctcaaa 21840
tatttagaag aagtaactcg ggacattgct acgtatacac tgctaagttt aagcccggaa 21900
tgcgcaaagc aaatggctac tcgttctaaa ctaaggcctt gagatcgcgc gatagtcatt 21960
gctaatttag agcttattcc ataatcggca gtgacggcca tttttagttc gtgatcatca 22020
acactttcga caaagtcatt gatattactg ttcaccgcgg ccataaaacc atgttgatct 22080
ttaagaacaa tcgttggcat attgagctca ccaagtacct cggcaacgtg aggttgtatt 22140
ttgcgtctaa tcggttcatc ggcaaatgca tttactcgag caaatgtata acccatcaaa 22200
gtgtagctgt ctgtttgaag agcaagggat aacattcccc ctcgcatgtt gtttatgaat 22260
atctcacatc ctctcgaact cacattatcg acataactat cgaatctgga tgttgaaaaa 22320
ttacgcccaa acagctccac cattatagag tatctgccca tgaacatggt ctttagcatg 22380
ctaaattgtg tgtagatttc agaagaggtt tcggcgtggc cgaactcgta attgcaatac 22440
agcagatcaa tcatttgatc gtccaatgca gaaaatataa catcatccac attttcatgt 22500
ctttgctgga tatctacatc ctctattccc tttccttcaa aatggcaaag gtccgtcggc 22560
acgatcgcat cgttaaaatt ttctccatct ccagcactca actgtcgctg cggaaataga 22620
atcgtatttg taagtgttgc caatttgtta tatgcagttt ttacagcatg ttcggaaaga 22680
ctccgttgtt gcaagtagtt atagaaattt atcatgccat tgaatagcag atgggatagg 22740
aaacggtatg catactctat ggatccttct ccgtgtgttt ttataaacga gtcatctttt 22800
aagacagata aaaaattctc aaaggtgccg caaaaaccga aaacccattt cctaagtcgt 22860
gtagtcacag ccacttgact attcagtacg taagttatgt cagaacatga gattgcaaga 22920
ccttgttggc ttctaatttc gcatctagtt tgtgttgcgt cttgatcacg gctttgtgac 22980
cagttgctca aacgccccgc attgacattg agccatttct caagtgtaat atgaggttga 23040
ttggcagccg tacgatagcg ttcaaaattc tccaaactta taaaagtata tgcaggcaga 23100
gtaaacacca caaatttatt gttgccggag gttttcaagt aatcatgtaa tctactcata 23160
tatgtactga cttccttatg agatgaatat aaacgtgtcc agccaggtag gttcgccgga 23220
ttattgataa atgcttccgg aacaacaaag ttatctgcca ttcgggcatg ctcctccgtt 23280
ataggaagtc catattccaa tgttttgaga agatctccaa attcgggttc tgtacagcgt 23340
ttattattaa taaatattgc ccaattattg gataagtcta aatatgatcg taatgtttga 23400
ttgcatataa tataagtcag aatattttcg cttattctta cattacacct cagtttgcta 23460
tgttcaaatg tcgattccaa tgaacttgtt tgtgtaggcg acccgacaca tattaatact 23520
ggttttaacc ctcttttata ttgtggagta cgatacacgg cattggtaag ccaccaacag 23580
tatacaatag ccgtaagtaa atatttcccc aacaatccgg cttcatcgat gatgattata 23640
ttactgcgtg taaatgatgg cagtgatcca tgtatcccga aagtcatcca agacaagttt 23700
cctctaggtt ttcccagcag atcttctaat gtccgtatta catcaaattt ccctggacct 23760
gtctccgaat ccaaaacttt cagcatactt ttcgttatat cggacaggac ttcccaataa 23820
tatacaatat cctttttttg taattctttc attgtaggtg gactggtcga acatacatat 23880
tgccatttac ccaaattggc ttgaacatgg ttgcctttaa acccaaattc ctggaatata 23940
gtgtttatat gtggcgatgt ataggaatta ctgagtttgc aatatatgtt ttgagatgca 24000
acttttgttg taccagtaat aatgcaatcc aaaatctctg ataatgtttg tatgcatgtg 24060
ctctttccag atcccgcatt gccacttatc aaataaacag cgaatggcaa gtctcgtgct 24120
tctaattcta cagggttttc atgattcgaa gcttctataa aataggataa cggtggaatc 24180
aattcatcgc tcagcgtcgc gtccgcaaga gctcttacac gagtaattat agattgtatt 24240
ccatgcatgg cggtaaaatt taaataggtc gcttcgcaaa ataagtcatt cgattcctgt 24300
gacattttca atagactcgc aaaaattaaa atttttcttg aattatttta gaggcgtgtc 24360
gtatttcttg taatggatgg ctatgatcga agagcgcctt acgatttaaa tagtagaaaa 24420
attaatcatc cggacttcga atcggttatg tcgcaacgag atatttttaa caacgtctca 24480
tcaaaacagt gtatggagaa tcagtggatt gtgatccatc ctactcgtca gacacggatg 24540
tttaaggaga tcctcgcagg tcgattagga tatactgatg gccagggtat atataactcc 24600
gtaagatcta cagaaaccgc aattcgacag attcaaaata ctattctcac ccttagcctg 24660
gatgcggtta gatatgacga tctaaaaaat gattggatac ggcatgctga catgcgtggg 24720
atgtcagcaa aaaaacttgc cagaacatat ggtatgcata gtgaagcaga agctgttaag 24780
gtagcagaaa atgtttttgt aacatggcgc aaaactctgc aaactacatt gataaatttg 24840
gctcgtcagc taatttcttg ctttactacg gccaatataa acacttccag tttttccaaa 24900
tatatagatt ggatttgttg ccttggtatc gttccagttg ttagacatga tcgttctgca 24960
agggcaacaa gttctatacc tacatgcgca ggcagatcaa ctgtttttcc aaactgggca 25020
tttcatgatg cctccagtag acttcgagtc gtcgatagtg ttatggctcg tggaaaacaa 25080
attgtgaatt acttatcgaa ttcgatgtcg gcagtaagca ttctcgaata tgacagaaca 25140
ttgatagaat ataatttctt taaacgagaa cttcgggtaa aggatatatt gagtggtgag 25200
cgtggggaat gtattgttat ctggaggcca gtaatgaacg atggcggagt tatttttgat 25260
tcgccaatgc aacgaatata caaggagatt attgaatgtc atgatttgcg tcaacatgca 25320
actttatgtc gacttgtcaa cacggctcct gtaaaagttc ttattgcaaa acgcgatgat 25380
ggatgtaagg gggtagcagg ggcccaacga gtcatcgaca aagttttggg agatcaacca 25440
gaaaatgcag caagttctgc tgcatccaga ttagtcaaac tgattattgg tcttaaaggt 25500
atgcgtcatg tgggagatat tactgacacg gttcgagact atttggaaga aacgagcggg 25560
catttattgg atgctgcttc gatcgataca tctcagccgg gtttcggcca atccaatcgg 25620
gcacaagctt ctacaaccga ggaaactcga cgtaatacca ttaaaattcg ggatgcattc 25680
cattcgtctg ttgtaacaag tataaacgag atgctagaag gctatgtgaa taaattgttt 25740
aacaccgttg aaggcttgaa agctgccaat aaagatttgc tagcaaaact ttgttccaaa 25800
gaattagaac tcgacagagt tcgtactgaa catcttatct caaaacaggc acacactgat 25860
atgggcaatt ctcagtacag cccgacatta gaaactttgg cgcgtgacct taaacatgat 25920
gttattgatg taggtgaagt tatggatgat gattcctatg ttgctaatag ttttcagtca 25980
agatatatac ctgcgtatga tgtagacttg aaaagacttt ctgaactttg ggaacaggaa 26040
atgctgcgat gttttaaatt gacacgagct accaataatc agggtcatga ggtttcaatt 26100
tcctactcga acagtgcgat aactttacta ctcgctcctt actttttttc cgtattgaat 26160
atttatgata ttgggccaat agtaacgaat cacgaggttt ataaatcaga ggaggagtta 26220
tgcaattcgg tatttgaaaa gacacgtatt cacgtttatc tggatgattt agcactaatc 26280
tttaatgccg atgtaaaaag agccatcgcg aaatatttcc tcgtcagaaa taattcggga 26340
aggcaacgcg aggcagaaga tttgcctgac ggccatcatg gaagaagaaa tgacttccat 26400
tctccatcct ctcgacgtga gcgatactct agacgctctg gttataaacg ccatagatgg 26460
aacagggaat cgagacgcga ttatcgaaga actcagtcga caaccaatgg cgaggatgat 26520
gatggaagtc agagagatta atggagtccc cacccagttt acaggtgtct ccgtctataa 26580
acttcgagta gcgaactgca ttagacgctt acatttgatt ttagcaggaa ctgaaactga 26640
cgaagaaata agcagtgata tatattacac gcaatgtata gctaaccctg cgttcaaagg 26700
tttcatattt atgattctca cggctatgga ggacgtggtg aaaacgatag gaataccgcc 26760
cccacttcta aaatatagat ttgtgtcgta ccatccagca gaacctttgg attttgccct 26820
ttgtttgctc atctcatatt tggaaaaccg gaacgtcagc tcatccgacc cgtcactata 26880
tgttcaactt caaagttttc tgaaatatgc atggtcgaca gtaacgccga tgcgcaaaat 26940
gcgtagattt ttatgtatta caaatacttg gttactaaat accctaatgg aactgagttc 27000
tattagtcca ttcgatagta atcatgttct tcctcactac attatataca aacatttaag 27060
ttctactaat ggagtttgtg atgtgttaat atctttatat gaatgtaaca atttaggtga 27120
ggcgttccag gtaccagttt ctacgcgagg aaaatgttct atcgtaatca acaaaggctt 27180
gttgaatgga gctttccaac aaaaatggtt aagtgatata atatgtgatt ggtggcatta 27240
tggacgaaac aatttaaggg gggaggaatg tttatttcac acataccaaa aatgaaaata 27300
aaaaatataa tgcaaacaga actttatgtc atttattatt aataaacata aacctatacg 27360
actcaatatc gaacgtaaaa tcatctctgt taacattgtc ccatttagaa gacagaacat 27420
tgattaataa tctagaaaat gcagccagta ttggtttcat ataatcgata caatctatgg 27480
caggaaggat tatttctcct tcaaaaagag agcatgtaac agaaactatt tttccatctg 27540
ctgtcacagt ttggacagtc tcgcgattga aaccactggt atcaaatcta gctgctgcct 27600
tcattcctag agcagcaatg tattgagtgt catcatacaa ttctgtagga cagctccaaa 27660
aggacacatc actgcggtga tcaaacgcta tggagagcag ctcttcgaac acttcatggg 27720
ttttttcccg aaccgtttga agagattcgt cagtatcatt gcttatgcat attttttcca 27780
gaagagtaga aagaccatgt tttgcataac ttgcaaatct aggttggtta ggaaacccta 27840
caaaatcctt atgatgattg gatttattcc acagccagta acagttggca ttccatgaca 27900
ttgcatgtgt ataaatgcct tccaaacgca gatctagtag aatttcgtcg ggaaactgca 27960
gccctattgt cgcggcgaaa ttattagcgc tctcagcaca cgcgttccgc aatatattaa 28020
agtcgcgctc atcatccatt ggcggacgtg ggacattttt tgatttgtcc atgaatgtgc 28080
cccacatccc gtctttgatg taagtacagg gagcaaacat aagagaagat gcggtagcct 28140
caacctcaat actaatatga ttcccaatgg agatgataga ttgatataca tcttcattaa 28200
gttttttaag caaacctcca aattctaaga taggccgttt gagccatggt ttttcgcgtt 28260
ttaaccttgc cttcactaca tcatgtaatc gagaatgggt gggaaaaagg ccaagatata 28320
aagttgcaaa aaatgcactg aagtcaaatt tggcgatcgc tgcattttct attagggtcg 28380
gatcgcgtaa aatacaagtt attcgtcctg ttgtccattc atcggctgct ttgtgtctga 28440
tatccgtaga atgtacagat aaaatgtggg acgtgtctat catggggaac ggatggtttt 28500
cgggagacca cggagctaat agatgaaatg ttctaggccc agctaatggc cacaggccgt 28560
ccgtatctac ataggcatct atcgcatctt ttatagctgt ttgatttgcg gtggaggatt 28620
tcacaattgg ccagcctgga aacccgatga tacaactata gtctacatct tcacctcggg 28680
gattagtttc aggaccgatg tacattaata taggtaccaa aatatttgtc gattcgttat 28740
cacaagagta tagtttctca tgccattttg cataagtagc taatagagca acaagcgaaa 28800
attcggcggg ggttgtaact aaacagtcaa aagacgtggg gacgagagac aatgctctta 28860
ccggaggctg taaatggtct aaaaccaacg tattgtccac aactttaaat attgtatttg 28920
aattgttgtc acatttaaat ttcttatatg ggctgttcac ttttttatat tcacgaagaa 28980
atcgttcttc ttttgtctgt atttcaattc tcatgtcaaa ctctggaatt tgacgggtac 29040
gtttaagggc tgacagttta atgtgggcca ggggtgcacc ctccgcatgc ttcatggcag 29100
tcgagataag acatgactct tcaacgctga tcattccgtc cgttttcaat aatccggggc 29160
gagggataga tctttctcct gataccggtt cgcaagctgt aactaaccca gtttgactgt 29220
cgatatagat ggttacaggt gtataataag catgatatcc cagacggtgt cttaattttg 29280
ctagagtcgt agtgagtaac gctttccata gcatgtgttg gtccgaaggg caagatggcc 29340
ataatccggt tacagatgcg gaattggtca tacctgctaa cattgtatca gtaatcatat 29400
ctgggttcag gccccaaagt ttagccatgg attttccgga gaggtttact gtagaatatt 29460
gtgccgagta ttgaccgcat gtatttcgaa aaagtagata gcataatgca gtgagtcctt 29520
cggtacgatt tttattagtc caaattctat acacagtcgt ataacaaata catcctcgca 29580
ttatctgcat catattagtt tttgacgatg ctgccatcgt tgatatggtt tgacgcattc 29640
ggttccaata attataaacg atgaaaatct acagcacctt ctacgcgtgg ccagagtgct 29700
gacggaattt ccgccaacac agattccaaa tctaccagat catgatatat acccaactct 29760
ttgtctaaac gagatcttaa taggtcgtac cacttcgggc gtcgaatatc atagcgcata 29820
ttgcgaaata atgacttgct tttcatcaag agggtgtaga gatccttgtg agttttgcat 29880
gacgttctat caatacccgc tccgtctaac agagcttcta tctccgcctt ccgtaaattc 29940
tttacttttg ttctacccgg aaatgttgtt gtactctttg tgaggcggag tccgaagaga 30000
atctcccatg tgactttaaa taaagacact gcatggctct gagtggatgg ttgactatgg 30060
tgagaatttt ggatcccact caaggcacat tttgttgctc gcacagggcg ttttaaggca 30120
gtttgggcgt caatcaagta acatcgcgca atttccagca cagaacgagc ataaatatca 30180
tagtcgtctt tcatgacgtg caacagtttt gttggatcta tatcagcatt gggtccttct 30240
aaagggttga tgcccaataa ttcggcccat ttacaacata ccctgtataa gtcccatctt 30300
ccagatgtat taaaatcgca tgtcagtatc gttgtatcta aggttccact tggtccaatt 30360
ataggtatat ttccagatgc ataataatca tatatacgac aaaataccgc ttcactgtaa 30420
agagccgccg gggttgcacg acatgcttcc agcatagtga tgtttatgaa ctgttctcta 30480
gtaatgggtt ccgctaattt tgttaggagt tctgtgagat cattggcgag cacagtaggt 30540
cttagatatt tctgaacaaa acacgctacc gcatcactat caattacgtc gacctctacc 30600
ggtaaagggc aggtagcatt tttgcgcaga gttttcatat cgcgttgggc agttatagaa 30660
tctgctctaa gaattactaa aaaatcacag aaggcttcag catttaattg gagatcacag 30720
ccatcgaagc gcacgtgtat taaatttgat tcaaggagag catgtagaat attaatacta 30780
tcacttacat tgtttagtgt acatcgctca aataaatgtt tgtacttaaa tcgtgggaat 30840
atgtataatg catcagcggc tctgaacgtt ggtatacaat ctcttctgaa attgtgacac 30900
aacatattgg taacttgaga aaagcgcgtt ggccatcctc ctccattggc gattacgtga 30960
tttagtagca tgggcgtaaa aaccggctcc gacctagctc ccgatgcatc gatataaatt 31020
agcacttcat taagacgcag tgatctaatt cgacccaaag attggtaaac cgataccatt 31080
tcgggaccat ttatcgtagg cttgatgtat gcaaacatac tatgaaaatg ggaatcgtta 31140
aaactaagac caacggttac tacggtagta taaattacga cgcggtagtt agaccatgaa 31200
tttatatcta ttggcgtatt tcttgtggaa tttaacacta aaaccgaatc cgtgtatgcg 31260
aggcagaaac gtgccacaat ctctgaaaat gatatagttg aggaaaacaa acaaatattc 31320
aaccccccct caagccgtct agtgagttct gaaaaaaacg tccgatcatg gagacttata 31380
tccaaagaac cgttgacgcc tgtactctgt ttaaatatag gctgagtatg agatggaagt 31440
tgtttgaatt cattcatcac cgaaagaagg atattagttc ccaaactacg gaggatcgta 31500
catgaccttc tagaaaaccc ggatgctgca tattcaccta cgataacatg tatattttct 31560
tcacctctca tgatggctaa catatctatc aattgagtat ttatagtagc gtccattgct 31620
acaatcttcg gacgatatct gagaagagat gtcaatatat tatcgacctg acataaatgt 31680
ttcatagttg gagagaaaag ttggccgatg gtcgacatga tttcatccaa tataacgatg 31740
tcataattat caagaagttt cgaatctacg cgatgtagag attcaatttg tactaagagt 31800
ctagaaaact ctctacctcg cataatataa tcgctggatg acagataggt acaaaatcct 31860
gacatgccag ccctattaat tttttcggat aatgtattgg taaaactgcg tctacaagac 31920
acaatcaaaa cgctcatatt tgaattgcat aaaatacact gcaaccagtt catgagagca 31980
gttgtcttgc cagatcccat aggtgcacgt actataagga cattgcgcgt tctcgggtac 32040
aaaggtgacg gaaaagtaac gggaccgtcg gattgacgct ctgttgttat tcccggtctg 32100
ttcttgataa tccagtctat aagatcctct ccatataaca ttctagacaa ggaggcgctg 32160
gatgcatagt ctatcatttt gagttgtctc tgattactaa cgttacggaa gaaagtcgcc 32220
ctggctgagt gtctatcgta taacactgat cagaaaacta ccggcggtcg tcgctatggc 32280
cagtcgagca cgaatggagc ggaattacag aggactgagt cacatagact acgtgcacaa 32340
aaagatgtgg gtagtccaag cggtgtgctt cgggatcgcc gtactggtat tctttggaac 32400
acttgttgcc gcgtctataa atttaactga gggtttcccg tgcttcttcg cagccgttgt 32460
agattataga acagttaata cgacactagt gcacacgggt ctcacctatc ccaggctggg 32520
gggcgtggtt ccagtattat tcttccagac aaaggcggta gtttttttct tctatgcaac 32580
gagtattgtt ttcgtgtttc tcgtatgtta tattactgtt ggtgccatta tatcgagcaa 32640
gaaacatgtg ggtgcggcat acatggggag tggtgcattt gtgttttctc ttatggcgtc 32700
gcctctgaca atcctattgg gtaccgtttc tatatggctt ctacaagcag ttgttatagt 32760
tcttgcccat aagctgatcg tactagcagc tgcggtttat cttgtccatt tttcaacgat 32820
aacatttttt tatgggtatt tctgtggtag gggtgtagat agtaaggtct acgctgagga 32880
tatttcatct gctaaggata tcgacggtag tttgcacaaa ttaattggta atgttcgagc 32940
aatgatggtg aacttactat caattgtgta tagcataatt ttgatcatgt cgtcgctaat 33000
gttcggaatg ctcttagcaa atagttttac attaaaattt tggcatgtga ttgtcactgt 33060
tctaataacg acttccgttt taaccctgat atatcttctt gtcatcgagt tcttaatcgc 33120
acggtatgta cacattattt tgggggcata tataggtctt ctaattgggt atggtatgct 33180
gtggaccaca acatgtgatt atgtaaatcg attctattat gcaatgggtg caaatgcaag 33240
caatttgcgt attgcatgtc atagcgtcct agccgtcttt acagtgttaa ttttattagc 33300
tatggtagtt cgtcttattc gggccagttt atatcatcgt cgacgatcta cgcgagcata 33360
tgccaaagcg atgaagttac aacaaaatgt aaaacacaga ctaagacaat tgagacggag 33420
ttataaacag cggggtagtc aatccgagga tgaacgtgca cttacacaat cccgttctgc 33480
tgaagcatcg gatgaggata caatatatga tcgagtctat tcaggatctg agagcgaatg 33540
ggatgattag gaaaaactgt gaaaccgata taataaaatg aaccataaga cttaatgatt 33600
gtctcattct ttattaaaca tcataacata cttttcatga tcgttatcat attccctatt 33660
tctttttcct ctacggccat tttttagtaa tacaaacttg ggttgcatga gaggatcgga 33720
acatctcaaa tcatccaagt cgaccgtatc ataatgttca tcatccagtt cgattacttc 33780
tccagattcg gtcgtcagtg tgtttttctt gcaacatcgt ctaagtgtgt atgttaaata 33840
cgacactgct tggcccataa atgatccaca agttctccaa atgcccgata tccagattct 33900
tctatcccaa cgtagaaagt attatctatg atcacaggag tgatgattag aatgacaggg 33960
attgcttgtt cgggagttat ttcataaacg acttccgaag cttcggtatc atcgacgaac 34020
aatgaaaagc accgacccaa ttcggtttgt cgtctatggc gacctataaa tgtagctaga 34080
aatggaacaa tctttctgtt tccgaagtat ccagaagcta cataggattg aagaaaaatc 34140
tgtttaaagt tttgatggcg gggatttgca aatatgggta tactcaaaac tcgttcaccg 34200
gtattccata agagtggata tatactgtta gtttggaggt cgggctcccc aaataaccat 34260
acgcgggaac tcatgttctt attcaacgtc aagtgatgca tctcaaattc attacattta 34320
attcttgact gtgcggcatg gtatgcagaa tggcctactt tccaatcatc atcagaagta 34380
attaatgctt cctttgccct agggtaatta tcgggtcgaa agtagtctac acagggacag 34440
tcgattgtat ataaaaacct ccgaaaccat tgcactgttt tcgttgccat caaacgttcg 34500
tagcactggg atagttcact tctcatttct ggacaaaatg catatttaaa tctacatttt 34560
atttcatatg tttcgatatt attatcggta agacaaggcg ccaatattcc atgtctattg 34620
cggttacaca tcaccatatc aagggacgct cccaacattc cagttctaat atctatcatc 34680
agaccacaag aatatttctc tatgtctaaa ataccggtag ttgtattatc gaattcgttt 34740
ttcttatcag agttgtcaat tgttcggacg gaagattggc tgacacagag tgctgcgatg 34800
agtgattttg ccaatgattc attgcgtgtt ccaaatagta tactctcagt ttgtccccgc 34860
gatggtaggt gattggtaat aagtccagcc gtgttgattg ttccattggg gctccacttt 34920
accgatgatg ctgtcagcaa acattgtcta aatatgtgcc acaattcact gttcgcttgt 34980
agtctagtta acgattccac cattttgcac cagcgagaag catgaattga tggtgacaaa 35040
ttatttatac gcgattcatc taggaggata tgttcagtct caagtatata tgaatactta 35100
ttttcgagca aacttccctc cgaaatgcct tgtttgatta catccgctat gtagaatagc 35160
cggtgataca aaggatgaag cgagtgtctg caatcatttg gatcgatctt ctgtaatatg 35220
tagttgccga aggtataatt tggtacaata ttttcacata tttcatcgta aggttttgtc 35280
ttagttgagt tagattgttc atctcctaca aggatttgtg aatcacagtc gatcgtaatg 35340
cccctctttc gttttcggga ctcatctttg caagatttgg agagtggaaa cttggttcct 35400
agttccataa caacaaatca gccgttcttg ctactgggtt tgcgtgacaa tagagagccg 35460
caagctccaa caggttgttt aaatagggaa aaatgtttaa cgaatcaaat agctttctat 35520
gtgtgatgtc atacgcttcc aaatatttat caaactcggc tctgtggcgc gagctgtgca 35580
attgcagacg aatcttttct gcccgttccc atgggatgcc atttttacta gttaaggggg 35640
tcattggaaa tagatgctgg tagagcatgc atctgtatgc tagtatatct aaaagataat 35700
ctgccctcat cagtctatga taataaaagt gtagtggatt actggaaatc ccgaatcggt 35760
gtgtaaaatt cataccggct gctagaatca cttccataag cgattggccc aatgcgtaca 35820
tatcaattga aactccttcg tcactagtca atggtgtcga acgtcgttcg aaacctactc 35880
catttaaggc ctttatcatc agttcacagg gctgtgtttg cccatgtccc aaaactaaat 35940
cgaacacggg tttaatattt cctctacaaa cttttaatga ctggatttta tcagaactta 36000
tattcacatc gaacctggat ttcaggatgg tagagtttgt gttaagcaat gctagactaa 36060
aatcaccaat tacagcatct actaaaatgg gattaggacc ctcggtgacg ttaacaaaga 36120
tattcccaca tttgatatcc aaatgagtca acccacaaga cacgtttaga aacacaactg 36180
ctttgccgag atccatgaac gttttctcta ttgctttcca atgttgcact gttttatcga 36240
ttcttgccaa tcgatgataa tatgaatcca tatccatatg atatgctgga aatactagtt 36300
ctttggatgg tatcgaaaag gccaatagtg gaatgatatt atttattctt aaagtggatt 36360
tcgcccgtaa tgcacattca ccggctatca atgtcataag taactcagtt ttaaaacatt 36420
ccaatacttt tttgacggct atgtccgtct tcttaaatat tttaactact ccgtagctgc 36480
cactcccagc atatattggc atctctttca gatcgatatg gctataatgt agctccgaag 36540
ttacattgaa aataaatgta gtcacattct ttatacgcgc caatgtaaat acatgttccg 36600
gtaaggacgg tctggataca agcttgtcgc tccttttttt agccggtgtt ttgcgcttca 36660
tacacagctg tctgagacat cgtctaatat tgtcggagaa acgtcttctg tggtgtatat 36720
ttccgtatgt atgccgtcgg gatgtattat gcgttccctg gaagtacatg ttataacttc 36780
gtgagttgac ggttgtccca aatctgttgg ttgtacgaga tcgtctttcc cagttataaa 36840
aacgttcctc gatacttttg tctggagtcc gtgtgctgtg ggagcaattg ctgttttcgc 36900
caccgttggt cgtttttttg ttttttgatt cagtatccat tttgtcagta aagcctcgga 36960
ttcttcatct aattcatcgg tgtttgtaat ggaatcgtta agtgttatat catcaatggt 37020
ttgtgctaga atgtcctcct tttcgagaat agcttcttcg gtctgatcta attgtaactg 37080
aagtttgggg ttcagcaatt tcctatttat atcaagtatg agacggcgat ctagctgctc 37140
atctatatga cgctgtataa tctttgtctt tctatcggtc gcttcgagtc tcatgtttga 37200
acgcagctgt gctttgtagt cactatgggc gtttctagct gacgtgaaca cttctataaa 37260
ttctggatca tcagtttcta caccttgaga caaaagttcg agagtccgtt ctttataaac 37320
agcttctcgt gttcggcatt ccgctaaaat ccgtcgcctc cgcctgcgca ttgcgctcac 37380
tgcaaacatt atcttgtcga ttcttggtca agtgttgaga tgtttggtgg tttacttggc 37440
gaagagacga agaggcactt cgaacggcta atgaaaacta agaacgatcg tttaggcgcg 37500
agtcatagaa atgaacggtc aatacgagac ggtgatatgg ttgacgcccc ctttttaaat 37560
tttgcaattc cggtgcccag acgacatcag acagtgatgc ctgccatagg catattacat 37620
aactgctgcg atagtttggg tatttattct gcgattacta ctcgtatgtt gtatagcagc 37680
attgcttgta gtgaatttga tgaactacgt cgtgattcgg tacctagatg ttatccacgt 37740
attacaaatg cacaggcttt cctatctccg atgatgatgc gtgtggcgaa ttccataata 37800
tttcaagaat atgacgagat ggaatgtgca gcccatcgca atgcatatta cagtacaatg 37860
aattctttta tatcaatgcg aacatctgat gcatttaagc agttaactgt tttcattagt 37920
cgtttttcga aattattaat cgcttcgttc cgagatgtaa ataaattaga tgatcacaca 37980
gttaaaaaac gtgcaagaat cgacgcgcca tcctatgata aacttcacgg aactctcgag 38040
ctctttcaaa aaatgatatt gatgcatgcc acttattttg taacttctgt tttacttgga 38100
gatcacgcag agcgtgccga acgtttgctt cgtgttgcct ttgatacccc ccatttctca 38160
gatatagtta ctagacattt ccgtcaaagg gctactgttt ttttggttcc gaggaggcat 38220
ggaaaaactt ggtttttggt tccattgatt gctcttgcaa tgtcttcatt cgaaggtata 38280
cgcattggat atacatcaca tatccgtaaa gcaatcgaac ctgtatttga agacattggg 38340
gaccgtctta ggcgatggtt tggtgcccat cgcgtggatc atgtcaaagg agaaaccata 38400
acgttttcat ttcccagtgg attgaaaagt acagtcacgt ttgcatctag ccataacacg 38460
aacgtaagta tcgcatcctt cacaaacctg tttcgtatac attcatacga cgttgggctg 38520
tctgtcatta cataaccttg tcagtcgaat gcacccttgg atcattatcg cactccatat 38580
ttcgggcaaa cagaccaaat gccacccaca agaatttaca ggaatattac tgtaacctac 38640
cccggccact attacatctt cgagcctctc tgtaatgcgt gtttctgtgg agggatttgt 38700
tatcagtcgg acagagttaa ccatgtccat gaatagaacg caaccgaggc tcttatcacc 38760
ttccaccaag agatcccttt gacgggcttt tatccacata catggtcctc gacagagaca 38820
tgtatgtcca aatgaaccac attcccataa aacattatat gcgtctatgt gtagatcaca 38880
atgttcacgg cattcacgac atccactctc gtgattaata aattttgcta gagttgcact 38940
taggcttcgt tgctgccagc cagcgggaca tattgccagt aaactctctt ccattctgag 39000
ataatagaac ctgcgtttag agaaagacca ccaaactccg atggatattg gtatgcagtt 39060
gtggggatca tcaggtggct gtgtacgttc aacaaaaaca tcgatgtcaa gttctatgca 39120
cggtgtcgtc ggtaaaaact cactagtcac atcagggata atggcatatg cctcagtaga 39180
cgagacattg gaaaaaaata tgacatctgc agaagatcct tcatgtagaa tagggtgtat 39240
acgtagtgtg gcagtcacag aatatgcacg tgttccattt gcgaggaaca agatatgaaa 39300
ttcttttcta ctcaaataca agttctttgg tcgcgtgagg tacataaata tttccaccca 39360
ttttgctttc cgcggttgct tattcggtgt tacgtatgta cataagctac tatctaaggc 39420
gattaatgca agcattacaa ccaaacggga ttcggctcgc agtgtacgcc atatgatgat 39480
acgttcgttt aatctacgaa cgaattcgat atccatccca tcacaatctc ttcctgagtg 39540
ctggtggcgt gtagatcttg gtatcttcag tctctgcgta gtcataattc aatacctgtg 39600
ttgaggattg gtcacatata cacctctgaa acgtaaggtc gtagcacctg ttgcatcttg 39660
ttggtgcgac agagacgtga gagaactgct tcaattcgtg cgacaggcca attaaattcc 39720
gtgtgggcag tcaacataaa ccccgcaggc aatacaatag cgatgtgcaa atgttcatca 39780
taacccacac atatataagc ataactttct ccgggaagaa acttctcgca tgtggcgtgt 39840
ggtacaaacc attcagggaa tgtacatgtc atgacagacc gattatatgg ttgcctgttc 39900
cataaatcca cccccccgtt tagaattatg ggaacgggtc tattatttaa ttttatacat 39960
tcaccccctg tgctataata atcgaagagt acaagacctg gtatttttgt gttcacgagc 40020
tgataatcac ctcctaaatg ttccgcagca ttttctgttg tatatctgcg atatgctttc 40080
cctccaaatt tatttatata tccggccata tatgagattg cggcggatat taacgcaccc 40140
gtactaaaat tttcccatga ggaatttgaa attgcattaa gagtggcacg aatataatta 40200
ggagtacgat tggtaatttc tgtgataaac gggaggtcgt atgcatgtat gtggtaactg 40260
atcatttggt ataaattggg ttccattctc aaggcctcgc cgatggcact tatgacacag 40320
tttgaaatat gtgttttaaa atcgatcatt aggtcaattt cagatccagc tgaaaatgct 40380
tgtagctggt tgtgctctct taataatggg tccgataaaa taggcgcttg tctagctata 40440
tcaatctttc tttcttgcga taaataacac ggatgatcta caccttcttc ctgacatgcg 40500
atagacagta aaatgtttag agatgttgga tttggtgtaa gatgggatga acgtcctccc 40560
aaagctacgg aattttcata tgctacaata taaaattgac ttttagtggt agaatggacc 40620
cgagttacaa ttgatatact tccacatctc cacagattgg cgagtgtaat tccatttcct 40680
aagatgccaa tggctgtcaa aaaaatctct ttggagtcta caggtttttg ggaaggggaa 40740
tcgaacatga gaacgtcttc aaaattcgtt gtgatctctt ttaattgatg gttcattgca 40800
ctgctaagac gtacattagt gttgccgtct ccaacgaatc taatttttcc agcgggttcc 40860
agtccattca taacagcctt ctgctgtgta ttcttgcttg gtaaatcagt attgtttttc 40920
aaacaagcaa ttgctccctg cttcaatcca gatacaaccc ccagagatcc tttctccagt 40980
gagccgctca ctggtgctct tttggtaata gcttcggccg ctttcttgat aagttgtaca 41040
atctctgtat tatccgcctc tattcgcgca gctatatcag gggtatcaaa ttcatgttta 41100
ttatttgcta agaggtgcat aatatcaaat tgttttgact gtgaatgtat tacatcatca 41160
acgttaccta tacatgcttc taatttggct cccagttcta taatagttac gggcaattcc 41220
gattcaaatt tttttgtata ctgcaaaaat tgaagaaata atgtctgtaa tcgttccgtg 41280
tcgttattgt atcgagtacc tattggaact aactcgtctt gtgtaaacaa tatatctttg 41340
tagctcttat agtcgccggt gcggatatca gaacatggaa ttcgaagcgc cacggatgta 41400
aacggatcaa atcgattttg cgagtcacat tcaataggaa gactaataaa taaggcaccc 41460
tgatcgcttt gattagatgt cgaaaaaact gcaggattcg taacttgggg taccaataga 41520
gagtgtaatg cacccgacgg aacatattct ccgtatacat tactccaatt tgagcatagg 41580
cccgtagcat tctgtcgtat ttgaacgccc acggaaacag atagagatga gtaaacactg 41640
gtagtatatc ttggtgatgc atctttaaga ttggtgagat ctattcccgc tgccgataaa 41700
cattcatcag gtattattat atgtgttaac agatgtcgca tcgccccccg atcaaagtta 41760
gataatgaat atatagtttc gctttctata tgcgcctcca tactggacgt cgctgttatc 41820
cgtcgtgttg cctacgtgca ccaatgttgt gactaaggtc tagctgtagg ataattatta 41880
ttaatgttga ggctatgcct accttcaccc tccgattcaa tgtgatctct tttttgttgc 41940
gcagagcatt cgtggacaag atttcaactt actatttgtc gacgaagcga attttatacg 42000
tccggatgca gttcagacga tcatagggtt tttgaatcaa gctacttgca aaataatttt 42060
cgtttcctct acgaacagtg gtaaggcaag cacaagtttt ttatatggtc ttaaaggatc 42120
ggctgatgat cttcttaatg tggtaactta tatatgtgac gaacatatga agcatgtaac 42180
agattataca aatgcgacat catgttcctg ttatgtattg aacaagcctg ttttcatcac 42240
catggatggg gcaatgagaa gaacggccga aatgtttctt ccggattcgt ttatgcagga 42300
gattattggt ggtggtgtgg tggatagaac catctgtcaa ggtgatcgaa gtatttttac 42360
ggcttctgca atagatcggt ttcttatata tagaccgtct actgtgaaca atcaagatcc 42420
attctcacaa gatctatacg tttatgtaga tccagcgttt acggccaaca ctaaagcatc 42480
tgggacgggt gtcgcggtaa ttggtaaata tggtacagat tatatagttt tcggtctaga 42540
gcattatttt ttgcgagcct tgacagggga atcctccgat tctataggct attgtgttgc 42600
acagtgcctt atacaaatat gtgcgatcca taggaagcga tttggagtga taaaaatagc 42660
catcgaaggc aatagcaatc aagattctgc ggttgcgatc gctactagaa ttgcaatcga 42720
aatgatatca tatatgaaag ctgcagtggc acctacacca cataatgtct cgttttacca 42780
cagcaaatcg aatggaacgg atgttgaata tccctatttt ctactgcaac gccaaaaaac 42840
tacagctttt gatttcttta tcgcccagtt taattcgggg agagtcttgg catcgcaaga 42900
tttagtttct accacagtga gtcttaccac agatccggtg gaatatttaa caaaacaact 42960
tactaacatc tcggaagtag ttactggacc aacatgcact agaacatttt ctggaaaaaa 43020
aggaggtaat gatgatactg ttgtggcatt aacaatggca gtgtatatat ccgcacacat 43080
tcccgatatg gcatttgccc ccattagagt atgatcatat gatgagaccc gacaagtgat 43140
gagttgtccc ttaagagtcc gaatgtacgt gcgttaataa tgaataaaat acaacatact 43200
agcatgaata tgattctatc gaatttattt atttaatacc agtttgcaat aacaggacat 43260
aagtctcccg cttttatatt ggcagggcca tcaaacgtgc atacttttaa tagaggatgg 43320
agagataata catttcctaa gttgagggtc atagtaatcc acgcggaaag tgcctcatag 43380
acgggatatc ttctccaagc atcctgcagg ggtgggggat ttggaattct aatgagttgt 43440
ccgacagctc ttgtcgccgt ctcaagaccc acgagagcgt ttatatatcc atcggatgcc 43500
cccaatgtaa gtagcgtagg gatcatagta tacaaaatca tatttccttc attgatcgca 43560
aaaatcatat tcaataacaa agttctaacg gtagattctg cggcatctag gctatgaagc 43620
gttggactaa tagtatatga tcttccatta tacataattg tttccgactc acgactggta 43680
ggagggggca tttgtcctct accgatagct tcaatggcac gagataaagt cttcgctaat 43740
atttcgtttg caagtctagt aggaacagta acgggaaata ggagctccgt gtcaatagat 43800
tcaagccgta ttcgacaaca gacgttagga aatatggggg gcattagaca gaccgtatct 43860
ccgttgcata ggtcaaacgg accagtattt tgtagcgcta ggccgttagg aatagatccc 43920
attcccaaga ctacagcgct cattcggcca ggcaaggcac gagtgatgac ggcagcaaaa 43980
cgagttttga atgttgatag gagactcaag gtgtccggtt cggttcccgc aatataaaag 44040
gacttataat ctacatcttt cagcaatact ctagctctga cgaatggtag gaatagtact 44100
cgcccctcac atcgttgtag taaatttgca tcgcatgtag ataacttgca cggaagctca 44160
atctctacta tcgtgccgtt ggaagtactc atggtaatga tacgagagat gtatgcgtcg 44220
tgatccttct attcacgttc gcggataact atacgggttg acgggaccgt cggccgatat 44280
atgaatgagt gggcggcaat cagtatcagt tacaagctca gcatatgggc aaacatccac 44340
caataggcga cgcatctcga attaagtatt gcgccaggtg tgtttctgga ttatcggtag 44400
tgcctgtaga atatgcgcgc agtaaagctt tatcagttgc gcataatata ggatatgcct 44460
cttgaaatag ggaacagggg tcctcggtca attcggtgga tccgattggt cgtttgaact 44520
gtacctctcc atcagacgcg aaagatgcca gagcagaacc agcttcacca atcagcttat 44580
ctagacatcg tgttttacag cacacttctg ccggggtgaa aaatttatat gtaggactaa 44640
aaagtggaga tgctccgctc agattgtaaa ccccgttgta taatttatct gcataggaga 44700
gtctttgtga tgcccacgga ttattggttg cacgaaatgg atatgcggga tccccttgtt 44760
gatgatcgta catgacatca tctatatcgg atgcttcttc gcccgaatgt atcgcacccg 44820
cagccctccc tcttggattg catggtgtcc taaaatactc caaatcagca gaaactggcg 44880
tgggaataaa ctcgcatata gacatctgcc catgttccag accactcggt agattaggca 44940
ttagtgtacc taaaaatggg acagttcttt gaggggctgc ccgttgtccg cgtgttgtta 45000
ctttgcgtaa gaattcatct gcctcttgat gtaaaagggg aggcgaacct cgtgttaggt 45060
gcaaactctg aacggtattt cccatatctg ttatagcatt ccgcaggagc aaaggagtac 45120
acgtggctgt atatcctaca cccaggtcaa cgttggcccg gggttgtgta agagaaaact 45180
gcacccctcc cgcatgtggc cgcttggtga ctgagacttg tcctagaaaa tatgattccg 45240
aagcgcgttc agcaaataaa cccatgtctg ctaaaaatct atcctgtcgt ataacagtaa 45300
atgcgattcc tggatgcaaa cccgtccgaa gttggtgata taggcctatg ggacttagtt 45360
tgaaatagcc tgccatcagc gcgtatgata tttcattggg accacatcgg ctctccttta 45420
catattgtgc aacgggctga cgaaacgtgg aatagtaatt tgctcccaga aatggtggaa 45480
ctggaggagc tctatacaac aaggttcgag agttaccagg cagatccctg actgccgcta 45540
aatgatcatg acatgcaaac aaggcgttca cggggacagg atagaagtat gttccagcag 45600
cgactgtttc atcattgcac ggataagcca tcattaggag accatggtgt aatgccccat 45660
cgaatgttcg catatgtcta gtggatgatg agctgctgcc tatatctgga gtacttccgt 45720
agaggattgc tgttgtccgc tctgccatat tattaacagt ttcttgtaaa gtaagaagag 45780
catcagcatc tacagatatt ctagcgttat gcaacatcac gttaaatgtg ttgggaacta 45840
aatttctgcc atttaaagga tgcctgggat cttcgggacc caggggaggt tcttcatctg 45900
gctggaggtc aggaatgatg accgattgcg aagtagcata aatgttgtca aatcgtatac 45960
ccatagtaca gcactggcct ctagagaaag aggggaccat tacataataa taaatctttg 46020
agagtgtagt ccactcttga gcgtgatgag ggacaaatgt ttgtcgatct gcatctcgta 46080
ttggcctatt atgaatgagg acattgccag ttctctgaaa atcggcgtct tgcaattcca 46140
accacggacg cacggcataa ttgttttcgc tccctacgtt tagatataaa tccctatcgc 46200
gcataccttc agcttggtat attagggggt cacaatccca taataatggc ggtaatatag 46260
ttctatctat cagaacgtga tttagttctt catgactctg tccgtataat ggatcagttt 46320
gtactgtata gtttcggaca attgatcgca gagcacgaac atggtgcatt aaatccttgt 46380
atacattggt acattcctct ggcagttccc cactacataa ataagtgtct ataaaggcta 46440
ccatgtgaaa gttgttgacg aatgcaactc gtttgcagtt atcccaatag cttcgtatac 46500
attgaatgac caatcgcatt aataatccaa aattacgttc acttccgtga ataacagctt 46560
caatgatata aaaggcagta ggatagctaa tgtcggaaaa tgttgcagac acagcattga 46620
ttgttgcatc actcatctta tggtgagtgg atgcaagttc ttgacccaga gcatctctaa 46680
aatcgctgtt gcaaagaggt agaggtatgt tacaattaca tactcgtagt gatgcggaaa 46740
tggaggccat aacttgtggg acgttatgtg gtcccgggag atctacatct cccgggacca 46800
caaaaaaatc aaatgctggg tgcaattcca tagatagata gggatttcca gtagataaga 46860
attgctctac ggtcatatga cactcatcta tccatctagg ggggtcgcgt agaaattctc 46920
cgatgttttc gaaaaattgg cgactggcat cagctagagg caacgctggt gggtttgtca 46980
catatgctcc aagaacacaa gacaaggtgt atttaccgtt acgtaaatta ccaactgtcg 47040
cttccacatc taaaaaagat gaatggcata gagttccgat tgcgtctgaa agggagagac 47100
taattacttg attgtctttg ttataaaaat atatttctcg aggaggaaaa atacgtatat 47160
cccctacatt acatccgggc ccgggagcat agtccccaat atgacgggca tatctatcac 47220
cccgtttttg atatattcct aaaggcatga taaatgttaa atctacatgt ccaattaatg 47280
gatattgaac ttgggttgct tggtaaacac gccgttccat ggattctaag aaaataagtt 47340
tatcgccaat ggttactagt tctgcagata tctctgctgt ttgaggtcgg tcatcatcgc 47400
cccgcacgat ttcatccgta cgatcaataa tattgtcttc ctttaagttg agaatatatc 47460
gtgcaatgtc gtccatgttc cgtacagctt tacccattac tacagcggtt actagattgg 47520
tgcccgatat tatcatttcc ccgtatgtaa caggtactct agcagaagta tccaccacat 47580
caagaattcc agataacaat ttctgtctta ccatcgtagt tgtcactaat acaccatcca 47640
caagacgccc ctttgaatcg gaatgtgtta atcgtggcat tgaaattgtt tggtgagtac 47700
agttgaccat ttttgtgagg aatgaaatta tagtgtcccg gttggcgttt gtcttattca 47760
tgataaagct ctctgtgcgc actgtacgtt tgagctcgga gaccaaattt gctcgcataa 47820
cctgtccagc aattctcccc tcggcttgac tgcgggaaag cggtatcagt agaggagctg 47880
gtggagcttt ctctagtaga attctaagca tttgatctac cgtacctctt tcaaatgaat 47940
ctaatatcgt tcttacattt ctagctaact gttgtatggc tctcattcgg agatgagtgg 48000
atattgctgt cccatctaaa gacacttcag ataataatgc gagggcttct gccgcgacaa 48060
cgaaagctgc gctcaaagat cttcgacata gacgttttac catataggta tgaatgggct 48120
gatccgcggg atgtggccct tcgcgcgcaa tcattggctg ttgtatttca aattgaacag 48180
ttccttctct catgtacatc agatctgggg cgcgtgtaca aacacatgca acagaaaggc 48240
ccgtttctag aaatcgaatt agagataatg tattgcagta agtcccgaga agaagatcga 48300
attgtgcagc ataacgtcca ttatcatcag aactgaattg cttgaaatag tcgaacatac 48360
atcgatgaga tgacatctct atagtgctca agagtctacc tgtaggcgct aaagtcgctc 48420
ctatgttgaa cggggttgaa aatgtacatg gtgccaccgg cggacaatcc cctgccgggg 48480
gacaatggca tccggccata atcgtcaata tactctgtcc gagctgggag aagttcgtta 48540
tagtagcacg atccgacgct gtggataatc cagggcagac ttaatcaata cttggagatc 48600
gagtcgaggg tctcgtttta atggacgagg ttattcgaat atgacacatg cgagtgccga 48660
tattgtaatg ggagcatgtg ataaaactat gtccataacg agggaaatag aactgcatga 48720
caaggtattt ggacgcccgc ttttatcttc actatcagac tcggtgcacg tggccccaca 48780
aataagggcg acgcccctta cattagaatg gcacacacga tttaagtact gctcttgtcc 48840
ataaccgagg gaggagaaat ccaattgcat ctgatataga tgttatagaa tatgcgagac 48900
tagctatcat caccaaatat attacaaatc cgcttgtctt caagtttgta tcaaaggcca 48960
aaattttttt cataaatgtt acatctttga atatcatgtt gtaagatatt gctacgaaga 49020
taattggacc tagcatagat aacgctccta ttaaaacttg ctggaattta ctcagaggca 49080
ttaagtcgta ttttatgttc gcgtacatat aatacatttc tagcatcaat gttccataga 49140
aaaatgcagt gattgttgta cccaaaatta aaaaccgatt gtcctgtgcg tatatggcat 49200
aaaataaaaa aattaaacag catgaaggtc gaagaacaaa cgtagataga ccaaagagta 49260
caacataccg agtaaatttg ggatgtatgt catagctgtt tggaattgta aagacataat 49320
cgcctaaata agacgacata gttgcataat caactgcatc atcccaatct acttcctcag 49380
atagttgtgt caatacagac ccaagagttt tcgcatctgt atccgatcgt ccatcatcaa 49440
tatcatcgag ggggatggta tattcattag cttctgttgc atagtatcca aatccatgct 49500
tcgacatagt taaacaaggg agtggcctat gttagtacaa ttcgtcgaat aatgtgatgg 49560
tctgagaccc ttattgcttt gccacaaatg gcgttcaatg acgagctgca atacccaagc 49620
tcattgtcgt tcatatgaac gcgacagtaa atacgctaca cgttaatccg tgcacccacg 49680
tgattaaaca gcaatcgcat cgtctcatca aggaattgcg atttggcgct acagtgatat 49740
aggtctacgt ccagagagtg acagtcaatg gatattaaat acggacatgt tctcgcttat 49800
agaaatgtcc agttttatgt atcggaatgt ggatataaag cgtatttctt ctgcggcggt 49860
tgtctttttg ctgtaggcag gcctcgtata gatgatgagt atctaccaga gctcgcaaaa 49920
attgggttgg ttctacgtgg tggtcagtcc aaaccattgg cagctcatgt tcgccgagaa 49980
ttacttcgca gaggtatgaa gtgggctttt tcttccgatg aagatgaatt gttcatcgat 50040
agtatagctg tgttaagtcg tgatggtata tgcagtgaac gtgagctttg tgggcttctc 50100
tgtctggaaa cgtatgatcc ggatatagca aagtatatgg taccgacaaa tgcaatttct 50160
gggttaacga tacaggccgc atacgatttt ccacatgatc gtacaattca tatacccgaa 50220
ttccctataa tcacggacat atattcagat ttagtatatg agtgcagtcg tgatgcattt 50280
gtgctaactt gtgcaagatt gactgaatta cctaagtctt tgagtgacct cgttgaagga 50340
ttatttgatg gcattcccac tcctagagaa gcattatcat cagagatatt cggcaggcga 50400
gtcgatgtta tagttacagc aaagaaagct gcaaacacga cgactgtgca acgcgcatgg 50460
gatattctac agcatggatg ccggggtaaa ttgaacgtaa acagtaacag gacaaatcca 50520
gtacaacgga aaaaacatgc tcggttcagt tctttcgtac aaatcaaata tataccaccc 50580
gtatttaaga tatggagttg cgataccagc tcttgtatgc cctctacttc tctaaataag 50640
ttatgggaaa tcttctggaa agtagactcg gtttttaata tgaacatgct caatttaaat 50700
tctaatctct atacggagaa tggatctcaa tccgacctgg aaattataca aagtgagttg 50760
gggatgattt caaatgcttt atttggaaga cacgcatcca tgtttgttgg agttggacca 50820
gaaaacaaaa atatatcgcc cagtcagaag tttttgttgc ttcagtatat acatatatta 50880
aatcgtctgc caaattgtta tgacttaatt cgcgagttgt gcgatcatca tacctctacc 50940
attgaggggg aatgccctac tgccatgccc gactgtgctc ttgcagacat gacaaacagt 51000
ttattcagag cgattttatt tcttggcatg gctactgaaa tagttgtgaa ctggatgcct 51060
tcctcattgg aagagcccac atcgcgagtt cctagtccat cagcctttgc agacgcgact 51120
actttattgg atgtggcaga aacatctgca ccaaaatcta tacaggacct caagatacgt 51180
aaactggctc ttattctaga cggtctatat aaagacattg atcccataga cgtcgcgtta 51240
cgagaatcgg tgggagaaga tacggcagaa ttgctatgcg cggccataga tatatcagtt 51300
ttatcagcct ttgaacattg ggggtattat agtcgataca tgcaatgtat tatatcattg 51360
atagacactc gtttgagaaa cagtgggtgt attacaatat gttcttaatc gagataatac 51420
gtcaaaccct cataatgcat ggatctatta ccgctgtaat acctgaaatg tgatcggact 51480
tgggaaaaat cttcacgcga aataaattct atacatagct tgttattccc aaaggttctt 51540
tatttatttt tgcattaaag atcgtcgtac aggctcaatt tcttatatct atgataattg 51600
tatctaaaat tattaataat cattcttaca gtaataattg ctattgatat agctatcgaa 51660
gccccggctg tagcagttgc gacgtaagtt gcagagataa tagttactcg ttccgattca 51720
aaagctaaga tccgtacgat tgtaccattt gggtacaata gtaatgatgt tccgtatatt 51780
tgggcgatag tagggttaaa ataccgaatg gatgaattcc ctcctgcaat cagttctcgc 51840
tgcaaatctt gtgatgaaat ataaatggtg tgtctaaggt ttccgtttgt tgagtatctc 51900
aaaaggacac aaccacagta gggacaatcg cttccgagtg gtctaggtag taccatggga 51960
acaatgttac cggctgtcgt tgtacacggt agtctaacat atgttatata aagttgattg 52020
ttcacgtcaa caccatccac attatagaca atacctctta ttccaagttg tcttgtcaca 52080
acataactcc ctagtccaga aatgggcaaa actaaaagcg ctgtagcttc taaaatatct 52140
gcatcagaac aagtcacaac ttctgatgca tatatagtca accttctcat caatggtgtt 52200
ttaagcttgg tgattaccaa ttctgctttt gtttctaatt cttcttcagc atcgatacca 52260
cgggaatcat tttccaaata cttctcgatt actggatgta aaatcacatc ggacattgca 52320
tatagtctat gatgatgttc ggaaatatcc atccgcaaag ctgtaacaca cggtgtatat 52380
acatctaaaa tatgcactgg cgagttttta acattgattt tgatatacat ttcctgtatg 52440
accagttccg tagctacgat atgttcttca gtacacattg aagacgcaaa caatagagcc 52500
ttgcgagcag tgcgagatgc atcccattca ttcggagggc gttgaaaaat actcgcaaac 52560
gcataatata aggcatgcct cgcagaagtg ttccatgcaa ttgtgtccct gacggattcc 52620
tcgtgaagag ctataatgag ctctaatgaa atgctcgaaa catgctcccc cagatttcca 52680
ctctcttggg atatgttgaa tgcatacgca gaccttaaaa catatagatg ttgcagaata 52740
gataaggaag ctgtattttt ggatgcattt ataatcgtct ttcgaatcaa agattttata 52800
atatcagcat tttcattccg caaatgcatt ccagataaca agaagtatgt accagggttt 52860
gaatgcaagg caaaagttga aagagtttcg gtaatcattt ttatattagc ttcagtttta 52920
attatttcat cgaaagaaat atagccagat tgaaacgcgt tgcgtacaga tgctactaga 52980
gacataaata agcgtgtagt tacgactcta aaacaatata tatcattaat atcagatatc 53040
ggtgtggcag caaatataaa aagctgggca tgcgtttgag caatctggaa atcataattg 53100
gatgattcct ctacactttc gatcatatta atatatgatt taatttccat atccgatgcg 53160
ttcatatgtg gtcctagcaa ataaatcaaa tacggacgtc gagtaaactt atccacgggt 53220
tcataaggtt tcagcgctgg ccagatcaac gaaatatttc tagctctttc cgataatatc 53280
aattcgacgg gaggtgccga tttcatagaa attgtaatgg aggcaaatgt tatccctatc 53340
ttcattataa cttcagcgcc atcggaacca aatataatcg ttcgtatatg tgcataatca 53400
accggaatga gcgtgtccat gggatccaca aaacatacat gttttacata ggttccggtc 53460
aattcactgg tgagaatgaa acgatgttca ggattaacaa catcaatagg ttttaggttc 53520
ttcaattctg ttggaggatt agttcctgta ggttgagcgt cgtctttgtc atctaattta 53580
agaccagatc ggtccgaggg aatttgcaca tttcgtcggt agggtggcat ggccgtcatg 53640
aacgagtgat tgatgtacga ccccgtattt aaaaatttga ttagattatt ggacgccaac 53700
agtttggata ccggccgttt gtagaaagtc atttgttgta catgacttgt tggcatataa 53760
aacaacacac catttgctgg gctggatgcc ccaatataca caaatgtagt attgtcacgt 53820
acccaggagc cttggttatt cgcgcttcca tcgagagata aaatattcag tcgcagagaa 53880
ggcagatctg taattcccaa caaggacaat aacgatggta gtgtattcgt tggtgtcttc 53940
tttgcacaaa atgcatggat cattatcaaa aaaactatac taccgggaag acccatgttg 54000
gatatgtagc catccaatgc aacttgcaag tgctacgatc cgtatgaaca cacttactaa 54060
atcatagata tttattggat ctaaggacgc caaattacta tcttaatata agtcaatatt 54120
gccgcatcat tgtgatgtgg gcaagctaat tatagaagcg cgatatgaat gggtagtttt 54180
acatagccat ctctttatta taggctagta catcagcttc aatctcgaag gcatcattcc 54240
agctcatatg tgttaccaat ctctccgaca tagtatccat gaacgattct acacactttg 54300
ttgtggacag gccagtaata ttaaatcgtt cgacgttaat gttccgcagt ttcattaata 54360
atccccacaa tatccatgca tgcgttgttg ataagctacc atcttcggca cataattctc 54420
gccgcttaaa tatcgctaaa agcgtatggt gtaatgacac cctactaccg cgataatcag 54480
tacgaggttc gtttataaac gttgtggcca aagatgtatc aaaccatggt agatccaacc 54540
attcagattc ccattcatcc ttactgtagg gacaaatatg atttgcgtac ataatagtgt 54600
ctactaaaca ggaatacact gcattaagtg ccctgagcat tagtagatct gttttctcgc 54660
cggtcctatt ccgtgaagat agacggctaa catgctcctt ttcgtcatgt agatcgacaa 54720
tcaccaagtt gcatcctggc ggttcctggg gcaaccttat tatcatacta attagcatct 54780
ccaaggaaca atctccagtt aaatgtcgag caatgggaaa acatacggta gcggatatgg 54840
gatgtcgatc tagaattaat ataagcgatg gattgccacg tgttcctgtt atgcgatgac 54900
acttcgacga taagcgctca tgaaatacaa gatagggatc tgcaaacttt gattgtaaag 54960
ctgttacaat catgctagat tgaaataaag aaaactctcc cctgcgacga cgatcacatg 55020
tatcatttac ggtcgtgacc aaatcagtaa aataataccg ccagtatttc ataggttcga 55080
aaacctttag tacgggtact cccattaaag agtgcgtcgg tatctcattc aacattgacg 55140
ttttacctat acccattgat ccatcgaggt atacacgtat gagctgtgca gatgtcatct 55200
gagatgccat taccgaccac gattgtggct ccgacatgtt caatgggaga gaagaacgta 55260
ctcaaaagat atcgcagaca ggttagtagc actcgaaatt tcaaacggca tgtaaatacg 55320
aatgtcctta gaaagcgacg tttagcggct ggtgttcgat gtcacgatcg cttttacaaa 55380
cggctttatg cagaagcgat gtgtctagga tctcaggtgt atgattggcc ggggagaagc 55440
tttgccaaaa tttttgggaa ggtcatggta ttagatgtat ttaaacagtt gacggatttt 55500
cgattggtct tcgaagtaaa cctagaacga cgtagaccgg attgtatttg catgtttaag 55560
ttgcctcgtg atttgtggga agtaggctgt gatggagtat gcgtcattct agaactaaaa 55620
acttgcaaat tttctcgtaa cctgaagaca cgcagtaaac atgaacaaag actcaccggc 55680
ataaagcagt tattggattc caaatctctg attgggcaaa ttgcgcctca aggatcagat 55740
tgtatcgtta tttgtccaat gttagtattt gtagcaagac gaaaactgtc tgttctacat 55800
gtgatgtgcc taaagaaaag gcacatagtg actgattttc atagactatg ctctatattg 55860
gcgaccgcgt ctgactataa agcacggata actgacactc ataaaatttt aaaacgtcat 55920
aatacaaaca cgatacatat acaacgacgc agtggaaagg cgtctgctaa cgtaacggat 55980
ttgaggaatc atatagcttg taataaaacg gctactttat cattttcaaa taatcaggag 56040
agaacgggag gtacggctat gcgaaacatg gctaatatta tcgcccgtct tgttcagaga 56100
ccgtaacact tttataagct tgtgtagttt aaatgtagta ttattttctc atgtggcgtt 56160
tccctgtaac ttctgtctga ttatatcgag tagcaccatc atggcaaact ttatttggga 56220
cgcgagaata ttgacaggcg atggaatgga aatgttccct gccgatgtga agaactttat 56280
agctccccca tggcccatcg agttctggaa ggaaccggta tttacatcta accgcgccaa 56340
tatggaacga caacttgcga tcattactgc acgaaacaat gccgccactg cagcattaaa 56400
taatttggat ggtcataccg actctattgc aatagaaatt gaccgcagac ttcgaccaat 56460
agaagaaaaa attgaacata tcgcaacagc gttagcggat ctggaacatg cagcggctgc 56520
agcagaactt gccgacgctg caatggatat tgccgttagt gctgttgaaa aatctggaca 56580
gcacaaggaa gacgttaata tcacttcggc ccgtgagatt caaatcgtga aaaatgatcc 56640
tttgctcaga tacgactcta atttgtctgt ggatctcttg aacttagtct atgcaaatag 56700
gaatgtagtg aactccggtg tcgttttcgg cacgtggtat cgtactttac aaaatgctct 56760
ggttgccgac aagcccagcg ttgccagaaa aatagactat catggtggaa gaatgtcgcg 56820
aacgtttatt gtgacggcaa tcacatcttt acaatcatgc ggacgtttat atgtaggcac 56880
ccgttattat tcctctctag aatgtgcgat tctttgttta tatgcattct atgcaaaaac 56940
tgggactaat atttctcatc ccactaactt tatgagtgcg attgagtcgg ttcccactta 57000
tttggagcat ctgtcaacga gacttgctag ttctgatagc agacaaaaat atggtttcga 57060
ttgggctcga cttccaaaag acactttcga ctcaccgtgt ggaaaatacg aacggggtgc 57120
attacacgat catagcattt taagggcttt agtaaattcc cgagttttgc cccccggtgt 57180
gggatccctt ccccgtggag atgtaattcc agaaattgat gctgaacaag gcatacgcaa 57240
cgacgaagtt aacagggctg ctgcagcgtt actgggacga gcacaacctc tctttctcat 57300
ggaagatcaa ccattgttga ggtctactat tgatacaatt acggcgttgc ttttacttca 57360
ccgtttgctt tggaacacta atatctattc ggccagggta aaaaacatat ttcagttagg 57420
agcattcgtt ccgggtatag ttccagattt aacagtgggg gcatctgtag atacgccggg 57480
ggatataatt aaaagcgacg gcagaaattt gatgttttta tttcaaagat atgtagctcc 57540
catgtatggt actgtgaaag gaatagagtt tacacaatta tttccggggt tggtagcttt 57600
gtgtttggac gtcccacttt tcagcggagg tatatttagt catagagcac cattatcacg 57660
tgtcgttgat gtctctctgg gtaaatatca agcctctctt gtaaagctca tttccctgga 57720
gctggaaaat agatctcgtg ccaatattgt atctgtttgt gaagtgatta cagcgcatga 57780
tttggtgacc cttcaatatg aacaggggtt agaatcattg atgcagatac aacgaccacg 57840
cagccgcttg ttcgagacta agaaattgtc agctttcaat gtagaaacgg attatgatct 57900
aatttatttt atttgtctgg ggtatattcc gaaattaata tctacgttgt aaagctcgga 57960
aatattggta catagctcaa tttttatctg aaatgaatcc ggccgaccat ccatcggtgt 58020
atgtagcggg ctatctggca ttatatgggg cggatgaaag tgatgaattg aatatcgacc 58080
gcaaagatat tcgcgccgcg attccgacac cagctccttt accaataaat atagatcaca 58140
gaagagattg cacagtcgga gcagttcttg cgctaataga tgatgaacat ggattatttt 58200
tcctgggaaa gataaattgt cctgtgatgg tacgtacact agagacagcc gccagtcaag 58260
aaatattcag cgaacttgat aatcttaaac cagatgataa attgctatat ataattacaa 58320
attatcttcc atcggtatcg ctgtcctcac gacgcctagc accgggggaa acggcagatg 58380
agactttttt ggcacatgtt gctttgtgtt tattggggaa gcgaattgga actattgtta 58440
catatgatct caccccggaa gaggctatag agccgttcag aaagctttct ccaaattcta 58500
aagcgacctt gctatcacag ggcaaggaaa ctgaacggct cttaggtgag atggtgtggt 58560
atccgagcaa aaatgcaata accaaagcgt tattaggaac ggcggttaat aatatgttac 58620
tgcgagatag atggcaaatt atctccgaac gaagacgcat ggctggtata actggacaaa 58680
agtatttgca agcatcatct tttacggcat tgaccgattc aatgacgtca aataacgtgt 58740
cagtcaccca cccaatttgt gaaaacgcaa acccgggtaa catacaaaag gatgaggaaa 58800
tgcaagtgtg tatcagtcca gcacaaacga gtgaaacgtt aaatgctgga gtgctgtctg 58860
gatgcaacga tttccataga cttccccact ccgaccctgc atcaacgagc gatcaaacca 58920
atttgcaatc gctaatagaa ccgtccatga acactcaatc ttctcgccca cccggagacg 58980
attttatttg ggtcccgatt aaaagctata atcagctagt atcgagaaat gcttctcagc 59040
caacgaatat tcccgatatt gcaattacat cgaatcagcc tccgtttatt cccccggcgt 59100
taatgaatac atcgatatca ggtcaacact ccatcccaag tggatatgcc caatatgggt 59160
accctacacc cgtaggtacc cataactctc tgcttccatt gggacctgta aatcaaatgg 59220
gcggatttca atatggacct caggtgtacc ccttgtcata tggacaatcg cctttagaag 59280
caaaactgac agccttactt gaatgcatga caaaggaaaa gagaccagtg gatgaggagc 59340
acagaggcga cgatatgcat actactaggg aagaacgagg acgacgtgga cgtaagcgac 59400
catacgaatt tgacagatct atcgagtctg atctttatta tcccggtgaa ttccgtcggt 59460
ctaatttttc tcctcctcaa gccagtagta tgaaatatga agaaactact gggggtcggc 59520
atgatctgag tcaaacagga cccgtattaa atagtctaat gggagctgtg acttccctac 59580
aaaaagaagt cgaacggcta aatggaggaa atttaccgat atcaaatgca caaagttcat 59640
atggagtgcc caatgggatg catgccccag tttattactc ataccctcct ccgggaacac 59700
atcccacagt ttcatggccc atgggagtcg aacgccctat gccttccacg gaaggaaaaa 59760
cttctaccaa ttccacggtc attcctgtgc cagtttcaga tccggaggct ggtcgaaatg 59820
taccaataac tgcgaccatc tctcaggagc gttccgacgg aattcagaag gaaagcatcg 59880
agcaatcacg ggataccatg aatgctagcg ccgtagctgg tatacaccgc accagtgatg 59940
ccggcgtcga tgtatttatt aatcaaatga tggcgcatca ataatacagg gagctatgtt 60000
tttagcatca cgttcgcaat atatcgtatt gaatatgctt tatatctcgc aataaatgag 60060
taaaccatat catgctctat gcgttttatt cagttcaaat ataatagtgc ccacttacac 60120
agcatcatct tctgagtctg aatatgtagt aggtaactta tcatatttag ggttactatt 60180
tttaatcctc atttttgcca ggtggtccga tagaacggcg gtagtgcctc gcctctttct 60240
ccgcagtttt ttctcgtggc gttcttccgc ggagactaac gccatatatt ttatcatttc 60300
tctagcttct tctaattttc tttcatcaat agatgttcgt tccaaatcat ctgattcctc 60360
gccatgcaac tcacgcgttg cctgtgcctt aagcacttct gttgtcatag gataaagggc 60420
tttcattgga ttgcttttaa gcttgtttac ataacgatat gctaaaaatg cagccacgag 60480
tcctgctata atgattaaac cgattgccaa agccccaaag ggatttgaca tgaaagcaga 60540
gacaccagat atggtagata cgattgcacc ggcagcccct actacaactt tgcctatagc 60600
ttgccctacc tgacccatac cgttaaacaa ttcggccaaa ccgttcataa acgcgtaatt 60660
tgtatccact tctattactt tgtttatgtc ataaaattta agttcatgta gttgattgcg 60720
gcgagctact tctgcataat ccaatacacc aacatcacgc aactcttctt ttgtgtaaac 60780
ggataaaggc aaaatttccc gatcttctag cagggttaga ttaagctcga caaatgtgct 60840
agcaatctgt atatcggcag cgtctaccat cttaacaaaa ttatagtttt caaataaagc 60900
ataaccggat ccaaacagaa aatatctacg atgattagcc gagcatggct ctacagcctc 60960
tagcgttgga agcaactcgt tgttttcacc gagttgtccc tgtatgtttc cttggttttc 61020
tccatatgaa aatagaacca atggtcggct ataacatgta ttagtggatg tgataactcg 61080
catagaattt tgcaaagtga cggattccgc atctatagca gtgcagctcg atacagcagc 61140
gacatccccc aacatctttg cagccactct ccttcctaat gttgcactcg ctgtagcgct 61200
aggattaatc tttatccctt cgtgccataa aacaagttct ctattctgca attcgcacca 61260
agctgtggca atcctactaa acatatcatt aatatgggtt tgtatatgat cataaagaaa 61320
ttggagcatg gcgaattgaa cagacgatgt cgatttaata gctgtggtgt cgtctaatgt 61380
tatttttcta tttggtgcat ttcgaatatc tcgccgcaat cgtgacaatg aggtagcatt 61440
tttcttataa attgcatgct tattgtttac caggtcgagc atctcatcgg tcctgttgtc 61500
tctcatcaat tctctgaggt acatatgagc cagggatttg gatagaacag gctgatatgc 61560
tacaataaat cccccgagag ccaagaaata ttgtacatgt ccaaccttga cgtgactgtc 61620
attatatttt gtcctaaata tctgctcgat tgctgcttct gcctcgcgtt taatacattg 61680
tcctaatatg atgcgatttg gatcaaactc agtcgtatta ctgataaacg ttgccgaaag 61740
ttcacgggcc ataaatctgt atctcccatt aactgttgca cgcaacattt cagtcacctc 61800
tttccactta gtcattgaac atacacgagt agtttttgga gcccagtccc acccaactgt 61860
gaagtgtgat gtgatgagaa agttacgctt gactggaagg cttgcttttc gacgcttgtc 61920
caaatccatt gaaaaatagc tatctagttg tttgaaatta tcctggggat atcccatggg 61980
ttctgcggca gcctctggtg gggatagacc ataaaatgga gatatgttcg cgatgtcgcc 62040
attggccatt gcaaaatatg aatacggaaa cacagagcgg gcatccattt cctctactat 62100
acaattgacg gaggttcccg ttcgatatat ccatggtgat ccccacacgg tatacgtctc 62160
attagtcgtg tgccatgccc tagattcggg cgtgttgaat tttgatggtt ttagaagtac 62220
ttgtttttct cccgcatccc tgtcaaacgc ttcaacatat acattgtttc taaggtatct 62280
tgctttagat gagcatcttc ctttgccgtc gattagatca gtgatctctt caatggaaac 62340
gggcgtccta tctgtatatc gattagtgat ctgtctatat gtcgtccccg tccatgtcgt 62400
cgtctgaatg atatttttat aataaagcgt tactttaaat ttatatggac tgatattctc 62460
tttaaataat atcgcgattc cttcacccca ctcggtggct tttctaggtt cgggacattt 62520
tcgcggcggt tctagacgga tcacggttga acccactggt gggggacaaa gataaaacgt 62580
agactcttcc tcagacaact ggacgctcga aacaacttct cttgatgtca cattttgggt 62640
actcggagat gagttcgtac catatagaat aactataagg aaaaaaatgc aattccgcct 62700
aaaatagtgc atagtgagat gatcttaatg atgctgttca taaattgtgt gagataaaat 62760
gcagggacac aagaatattg gacgggtcag atgggggcgt ggctgttggt aatctgttct 62820
actcgcacct gatctgccgt aacgggggcc atatactgca aaatagaata aagcaacgaa 62880
aaaacatctg tatcaataat tgcagtcata ttttgcgttt ctgaagtgct tgattctgac 62940
cccagaatca ttataagtgg atattcggtt tcatatgtta tatatattcc atttttccat 63000
acatagtctc cattgctgtt gatctgcaaa ctgtcggcac gacagatgtg caattcgcca 63060
catttaaata cagaagaaaa taaagctgtt gcaaaaatca gttctttgat atatttccaa 63120
gccatgcgat gggccgcagt tacattatct atagtgctaa agtcataaaa ccctctaaac 63180
ttactgacgg tccaatctgt ttttctactg ctatgaaaca tgaatcgagc catttcctcc 63240
tttaagtgag gaagcagccc tacattttca acactaaaat ataatgctgt attcgacggc 63300
tgggcgaacc gatgtctatc gtgactaaac atcggtccat tcacaagttg aaaaaatttg 63360
tgagtgagac ttggaagcat agcaggatct attctgtgtt tcagtaatga tgtttgcatg 63420
aaccgatgag catcaaatgc atcgtcacta ttacgattat caatgatgtt tgcacagcaa 63480
tttttaaccg cttccaataa tcttttcctg gaacggaacc cattgaataa tgccgtataa 63540
gagtctatca atacttcgcc atatacattc acacgcaaca ttttttctag ttcatgtctt 63600
tgttcggtaa tacatttatc cagactcgct agggacttct ttgttaaacg ctctgcatac 63660
attttacgtc tacgagctac atcacttgat gccgatttta ccatctccaa ccattcatca 63720
tggccaaggg aggtcgtcga catagcaaaa ctgtcattag tacgaaaatg ccccgtctcg 63780
ttcatacgct ctccacatgt gccgtcgcca tcttggcatt gaatgtcatt tcctatacaa 63840
tgtgaagaaa cccgctccaa aacagttttg agagcatcat gcgccgcttc atcgggatat 63900
aataggcgtt ttagtaatgg tgccgacata tgatgatcat aacatgcctt tattaatgct 63960
tcaatgatat catcgggtgc cgctgcccta ccccctaaaa gtaatctatc ggctgcattc 64020
atatgttcta tttcctgggc aaatacacgt tcaaagtgat ccatacgtcg atcaaacacg 64080
gctgtttcta cgattgaggt tctcagatcg aaaagacgtt ctttggatac caatgcctcg 64140
agattatcag caaatgattc tactgtattt ccgcgtggtt ggtgtagttt ccgtccggat 64200
gaagcaatcc aaaactgtaa ttcgctgata gcatataaat cacccgaggc tggaagaaac 64260
acgttatgag cgtccaaagc agcagctgcg gctttcgaaa cagaaatgtt actatcattc 64320
tcggtagtag tgtctctcat tgtagactgg attacatcta gtgcagtttg ggcggtcgtg 64380
cgcttgtcat cgggcacata cgtagcgtgt ggtaaatgtg ttaccatatc atccgaattg 64440
acacgaatgt ttatttgttt ggttatatga tcacaaattt ttctgacgat acgcttatgt 64500
gttgaatctc cactatttgc tgttacacaa agttcttcaa aacaaacaga acatggttgg 64560
gaagggtcat ataactctgg tgggacgact gaccccgaac ctaaagtttt aagtagataa 64620
ttgtctagac tcaccatgaa attttccacg gtatcggctt ttaaaattag atggcagtaa 64680
ttgagctgct tcaatacatt ttccacatca tgtagaaact ttatttcggt ggataccttc 64740
ccaccataag tatccaactc gactgtgctg tgatagggac agtcgccaca catagacata 64800
gattttctaa aaaagtctcg cagatttcct ccatccttaa actcgcacaa tgcatccaat 64860
aacaattccc cttctaattt ggcccgccgc agagccaacc ataagccata ggttaagggg 64920
gtaagattca tctcacgttg ttcctttaat gcaggcacca tcttcttttc caggtagtat 64980
atcataagaa cattcaactt caaccgattg atcatccgca cgcctaccgt cggatcgcat 65040
cgtttcaaga gttctacctg aaacaagtat gattgtatct ggccccaaat agcgaatagt 65100
ttctgagtgg caaatttatc atgctctgta ccctgcgact gcaaccggtt atgagacatt 65160
cccaacatgc ttcaatcccg cacaaccgac gtgtgagaaa atataaagat ttgtgtggaa 65220
tatatcagag ttgtcaaaat gttattacgc catttccgga ataaagaaag attacaagtc 65280
gccacaaaaa tatagctata gctttattgt acatgaatcg aagacaatgg tatacatgcc 65340
cgatgtaacc tatccagaat tacaacatat ctacagataa cactggtgcg cgcttctcgg 65400
gaatgggctc caggtcaaac acattcatat tcggacgttt taagttggtt tctgatatgg 65460
tctgcccatc tgcatgtcct tccaaattct cgtcacatgc atcaaaatcg aaagtaggtc 65520
catccgtggg tatggacatg gccatattaa ccatctcctt tgctaaggtc atcgccgcat 65580
ctgcattcca tccaccctct gcctcttcta cctgtttgtt gagctcgtct atcaacgatg 65640
agatatactc atcatttgtt atttccatcc agtcctccaa ctccatttga cgcacacgat 65700
cacctaccat ttttaatgcg agcatgtata ccgctgcatg tggtgctgcg gattcctcgg 65760
atagcaccat tcggactcta tctataagcg tggtttcttt tattcccgag gaaaatattg 65820
gctgttctgc tacaaaccca acccgagggc atgtcattac atagcgatgt gttctatcaa 65880
aagacattaa tgaacacacg tttctcccac ccattatgtt gccccagttg ccggactgga 65940
atactttagt actgccagcc attccgtgat acttgctgat acttatgcct attacaacaa 66000
agggtttcgt agtcataatt gacccaacta gattggtaga agaaaaggtg gcacaccata 66060
tatctttatg gtcagacatg gatgcaatga gctgctgggc ggcaggggcc acgtcttgcc 66120
cttttgttat aggacgttca atccaaggca aaacgatagc tggatccctg ggtcgcctgg 66180
aggcagcaac caatgccgaa attgtattaa taaaaaagtg tttgtgggaa cagtacttca 66240
aaatagtatt tgctagataa aattgtgcca aatcaccaaa gcacgtggga ctaatattta 66300
tgtaattcat atcagcataa ctctttgtga attttttaat gaacaaagat ttatcttctt 66360
cttccttaga gagtatacca gctggtaact gattgcgtag gagcaggatc caaaaccaaa 66420
gagcattagg agtcgcccca ttgggcattt taacatccgg gaacaataga gtgtgatagc 66480
gcttcactgc aaatccaagc ggaccattga gaacatgcat agtcttagtc ggtcgttgat 66540
acgcttctac catacccgcg agcctagact ttgtagcttc cgatgcagca ccggcgatac 66600
ctccgccgaa cagcaccttg ttttttactt taagctctct gaatatctcg acagtcacct 66660
ttactagatc cccttccata ttcgaaatca cggaatcata ttgcgattta ctggggtctg 66720
gaacacatat ctgttggtct tccaaggtga ccgttatagt tttagatgta ataaacccgg 66780
cattctgtaa ttccaatacc cgtcgtttca gtactgcttg gaattgagtt ctgaaatttc 66840
tagcttcaac ttgctgtccc tgcattacta tggaacactg gcttagggcc atatcttgaa 66900
caacggcaat gatggtgcgc ctggataaaa acgctaatac tggacatatg ccggaggcat 66960
atggttctac tgccagcgac agggtatgat ttgcatcacc cagaccctcg cgtatattat 67020
attctcgaat ttctgtcaaa tttcgcataa gctgcgaagc ctcactttcg attatatttt 67080
tcatggtcga tatagcacgt atgaatgaat tgccatctct aatgttagca tccgcggacg 67140
ccatgttcgt aggatcatca caagttaaca gaccttcctt ttccaatgct ttcatcattc 67200
gttctaccgt caatctatac gtatcctgca ttacgctacg gcttgcctcg ccttctgatc 67260
gcttgagggt cgaaaattga gcgtaactcc caagcgcatt tacatcacaa taattatttg 67320
tcattgctcc aaatagaccc atagccccac gcatctggta tccgaatttg ggcaagcggt 67380
atactaggcg cttaattgta gtatgagcac agtatataag cgacgtctta tcacataatt 67440
cgcatggcat gtcggcatct atggccgacg agacaaactt tacagtatct aaatcatgat 67500
ggcaagcttt ggcaccacca tcacatcgtt ccaaatagaa taaaaatcta gccaacaatt 67560
gcggacaaaa tccacaggcc aaaattagat aatccaatga atactcggat tgactggcgg 67620
atgtgctttt ggataaattt tctcctgaaa cgggtttccc atctcggtca actaatgggt 67680
tggctgacaa atgcggtgcc gctatttgga aaaatctata aaacgatgga gcagttgtac 67740
tcgtttcttt tccttccgtg ctaccagctt cccctacttc tgtcatgtat ataactgaat 67800
tggaactgaa caccatcgct cctaccagcc ctgccacgcg ggccatgtac gccgataatg 67860
cttctatcct atcggcatat ccaactggat tacaatatat cggccattta ttcacatcag 67920
gtatagggtc ctcatatacc gatgctgaaa tgacattttc gatagccaaa gtagcatccg 67980
acgccattaa agaagcagtg cgccgctcat aacccccacc agatacatca gatccttccc 68040
tttttcccat tttagattga cccttagtag tttctgccgc aggagtaaaa gcggtgaacg 68100
ttgtgtcagc gggcagtaat gtcccctcgt gattttcatc gaagcataaa tgggcagcac 68160
cacgtgcaat agcatcgata ttgcgaacac gaagacctac agctgtagta ctgagcacat 68220
agccatgcag taaacgacat aaggaatcgt tataaaaagc ttttggcatt attgcgcctt 68280
ctccgagtgc tcggggtttt tcgctgaaag gttcattggt aatgcgattg aagtctggta 68340
atactaaatg cagagggtag atagggatcc tgcgcacatc agcattgtta atggtcacaa 68400
cgtcgctgcc tccaaagtgt aagaacgaat tacataaata tatgacctct ttaaataatt 68460
cggtgactac caagtacaac atcacatttt gggcatccat ttcgagagct tcacaaattt 68520
gttggccggt ggtttcaaac gcagtcgggg cgggagacga ataggcacta tagccaaacc 68580
tttctcgtgc caaatcgcat gctttggtga gatttggagc cttcgtacaa ggttttatgc 68640
aatctccgcc gtaaaataca aaaacgcatg gatggtaatg tgtagggacg agcttaaggg 68700
tagtaccccc actgcccaaa cccgtcgttt tcgttcccgc taccgctgcc acgttccaaa 68760
cgaagtctga ctcgaccgta agacctgcaa ccagcggtaa tacagcatca tcacaatcat 68820
tgctttttgc cgcgaggatc gccaattcat ccacgggaac gctacatttg ggcgtcgcat 68880
atatatagcc tatcggtccg ccgcaaagtt tcacgctttt tcctacacca tccataatgt 68940
tgttgttgga tagttgacag aatctagtgc gagaggaata tagaatcaga gtagcagatg 69000
ccacaaacac tatctccgcc cgaagacacg gtacacttca tcatgtgggc tgttttaaag 69060
ctatagtgct gaagggggat gtgacgcagc tatgtttatg tatgacatga gacacgtggg 69120
atagtgtagg tgtataataa ctctaagtca cgtttatgaa gtaggattgg ggcccaattc 69180
tgacgatatc tgcattggct actatgtcag tagacggaac taaaacattt ttcaatccgt 69240
acatcggagc acgaaagagg agtcttgaag caaggaatgg cttatcattt tccaccggac 69300
aaaattatga tgaaaagaac aatcgacgag atcgtaattc aatcacgtat gttaccacta 69360
tagatgagtt taaatatatt gctcccaaat gcctagatga caaagatgta aaacaaaagg 69420
gaactcatat cggcaaattg aaaagatcac cggtactata caaaaatggt gaagaatatg 69480
tctttctaaa ctttgaggat tgtgaggatg tgtggccgcg gaggtgttct atatggaata 69540
atagatcatt cctccccgca gactttgatc cacgcttctc taggtttcat gtatatgaca 69600
tgatagaaac tgtggaattt gcaagcgccg ccatagacag agacaaaaac cgttttttgg 69660
agctgcttcg cccgatgggg acaattgtta ctatgatggg aattacagaa tgtggcaagc 69720
gagtagctgt gcatgtatac ggcatcaagc catattttta tatgcgcaaa gtcgatactg 69780
ataccatctg cggaagccgg tgtcctcgtg aacttgccga aaaactggca aatgtcgtac 69840
gttcctcagt aaacgaggtt gcgaatgcaa aacgtttttg cactccggtc acgcgtactg 69900
tatcggcaga ctgctttgaa gtagatgtcg tacagcggaa agatatatat tattatggaa 69960
ctggccatga cgaattttat agggtaaaat cccagagcgg caaattcatt actcttttat 70020
gcgataactt ctatccctct ataatcaaat atgaaggaaa catagatgcc atcacccgaa 70080
tggttctaga taacaacgga tttagtacat ttggatggta ctctttcaaa gttggtaata 70140
atggcgagaa agtgcaagta cgagctcctt gtcatcattg tacgtcatgt gacatcgaaa 70200
ttaattgcac tgtagataac ttgattggat atcccgaaga tgatgcatgg ccagattaca 70260
aacttctatg ctttgatatt gaatgtaaat ccggaggagt aaacgaatgt gcatttccat 70320
gcgcaacaaa tgaagaagat gtggtcattc agatttcttg tctcctatat tctattaaca 70380
ccaaacagtt ggagcatgca ttattgttcg ctcttggtgc ctgtgacctc ccacaaacct 70440
ttaaagagac gtttcaaagt agttacaata ttttgcctat agtgttagaa tttgacagcg 70500
aatttgagct cttactcgcg tttatgactt ttattaagca gtatgctcca gaatttgtaa 70560
ctgggtataa cattgtcaat tttgattggg cattcattgt taccaaatta acaacagtat 70620
acaatatgag gttggatggt tatggagtgg ttaatcaaaa agggatgttt aaagtgtggg 70680
atgcaggaac taatcgattt caaaaaaaag gcaagttcaa agccactgga atgataacgt 70740
tagatatgta ttcaattgcg acagaaaaat taaagttgca aagttacaag ttagatgtcg 70800
tggccgaggc tgcattagga gaacggaaaa aagaattgtc ttataaggaa atacccagcc 70860
attttgcagc aggtccagaa aaacggggaa ttataggaga atattgtctt caggattcat 70920
tgttggtggg aaaattattt tttaaataca ttccccatct agaactgtcc gcaatagcaa 70980
aattagctgg tatattgctg tcaaaggcta tattcgatgg acaacaaata cgcgtgtata 71040
cttgtttgtt gcgtttagcg agatcgcatg gctttattct tccggaaaag aataagaaat 71100
ttgccgaaac ggtgtccctt acctgcgagg aagatcaaac agaaatatgt gaacacgatt 71160
ctccccaaga acccattcat aatataaaac aatcatcact ttgtcatagc aatagtggca 71220
gaactattgg ctatcagggc gcaaaagtac tggaccccat atccggattt cacgtcgatc 71280
ccgtgatggt ctttgacttt gccagcctgt atccaagtat aatacaagca cacaatttat 71340
gctttacgac actagtacac gatgatacaa atttaagcaa tttacgtccc caagatgact 71400
atttggaaat caacgtgcaa ggcaagctat tgcgctttgt gaaaccgcat attcgcgaaa 71460
gtttattggc gatcttatta aaagattggc tggccatgag aaaagcaatt cgtgctaaaa 71520
ttcctgaaag ctgcgacgag attgccgttc ttctggataa gcagcaggcg gccatcaaag 71580
ttgtatgtaa ttcggtatat ggtttttgtg gcgtatcgaa tggtttatta ccttgcatag 71640
atgtcgctgc gactgtgact actataggtc gcgatatgtt gcttacagta cgtgactata 71700
ttcacaaaca atggggtact agagatgctt tgctccgcga atttcctaat ttgagtaact 71760
ttatgcggcc agaggattat tctgtcagcg ttatttatgg agatacagac tccgttttta 71820
tcaagttcaa aggagtagat atacatggac tcgtaacgac cggggacgat atggcaaagc 71880
gcgtatcatc agatttattt tccaaaccta taaaacttga atgtgaaaaa actttcaata 71940
agctgttact tataacgaag aagaaatata tgggaactat tcatggcgga aggatgctaa 72000
tgaaaggagt agatattgtg agaaaaaata actgccgatt cataaataca tacgcaaaaa 72060
aattaagtga cttgctattt ctggacgaca ccgtggcaaa agctgctgct acagttgcgg 72120
aaaaacctcc gtcgttttgg gctacatctc cccttccaga agggcttaat tcttttggcg 72180
gtgtcctggc cgaagcgtat actcgaatga tgataaacaa tataactgag gtggaagact 72240
ttgccatgtc tgccgaattg agtcggccgc ccgacgccta tactaacaaa agaattcctc 72300
atcttaccgt ttattacaaa ttggccatga ggtccgaaca attgcctgta gtgaaagata 72360
gaatatcata tgttatagct gcggctacac cagaagtagt gcgggattct gcccgtgtag 72420
cagaattcag aggggagttg gatctctgtc atcagaatag caacacttcc tgcccggggg 72480
attcagtcat gactaacaaa gaaacttatg tgcgacattc cccccgaaac aagttattga 72540
tttccgatat ggcagaagat cctaagtatc tattagcgaa taatattcct ctcaatacag 72600
attattacct ctcacatctg ttggggacgc tatgcgtaac ttttaaggct ttgttcggaa 72660
atgatgtgaa aataacggaa actgtgttga gaagatttat tccagaaacg tttacagaag 72720
attgtagtta cacggaacgt gtctccagtg aaatgttcac aacgatacga agcggaatcg 72780
gtttacaagt caacgaggag gaagaaactc gtcgaaagct gaatatagct ttccgtattc 72840
taacagcaac tccccatcga tattaagatc gcataattta caataaacat cttcagcatt 72900
aaccgctggc acatcacaag aatctgtttg tctgtcatat tcctttctaa ttactaacaa 72960
aaagttagta cgccatacat gagcaattat gcggtagctc ttacatgcac tcttcataca 73020
atctattaat ctgtagtgga ggtggagagc ctttccgggg aaaacgatat acatcatata 73080
ttccgacgat cctgcttcac gatctaagta aaatagcact ttcacgttct ttatccctga 73140
atcaagtaat acataataag caaaaaatag ttctggtatt gctataatac gagtaagtat 73200
agattccata tctttatccc gcgcatctcc ccgcagtcga tctcccaaga caattataga 73260
agccaaaaaa atcctataat gataaatgtt atttatctgt tgtacatatg ccaatattaa 73320
agctgctctg tcgtttcgcc ccaaacgtgg atctccacta gatacgcatg taggacaaca 73380
tccaccaaca ccaagataat atcccatccc agataaagac aaacagttat ccgcaaccgc 73440
ctctgacata tcaaatggta atgatattga cgttgtcttg ataagcggtg taactaaatc 73500
cttgactaac atcagttcat cggctggaga ctcggcgatg aattcaaaat aggcacgata 73560
tatatccata ttagtccttt tagaattgcc ataagatggt aaattcatat ctctccattg 73620
tcgccgactc cgtccaacta gccttttatc gcgccctata gatttgcgtc tcactaaggt 73680
atgaccagtc atattaagaa ttaatatatt acacgtagac tcctaatgta tgctcgagag 73740
atatcaagga gatggaatgt ctttgcaaca atgccccagc gtctttaacg aaagcagaca 73800
gtgcggttgg acggggagga aagacctgat aagttttaaa cgtatacgcc aaagcccaaa 73860
gtccagcaca tacgcgacct tcaaaatggt tctgactggc gagacgggct ttatataatg 73920
ctagttcgtc atgattggtg gcatctgggt gatcaaataa cgatcgtgga ttggtctggg 73980
ctattcgtgc cgcacacatt ggatcgcaga ataggtgttt ataaatggcc tcagttcccg 74040
cgcttttcat taatgttaca aaacatcctt cgtcccccaa atctgtacga tgtccctgtg 74100
atcgccaagc atctagaaca ggttctatgc tatgaaataa acctatattg ttggccgaat 74160
atgtgatgat atcgcgttta aatttacgca ttgccagcca atatgtacgt atcagcagca 74220
ggttacataa taaacactcc gcagatgttc ctccttttgt tatcgcgtgc tttaactgtg 74280
ttatcatcaa tgggcctaac tctaaatcgg gttccgaatc ctcaccgtaa catgcactgt 74340
atgctgcagt aacgtcatta gcaaattccc ttctatgatt tttccaaaat gtatccaccg 74400
tttcccttct aacttttgcg gccatgaatg cgagttcgct cgctgcctca ggtgcagacc 74460
ccgttcccgc taataacaat aaaacgaggt tgccataacc cattgtacaa tcctcatttc 74520
ttgcatgttc atgatgttcg cattgagatg catctatctg ttgcatgtcc tgaacatttt 74580
ccaccacatt taacttttct tcacttgctc ggagttccca ctcgtgttca taatcattat 74640
cctcggacga tgcgcgcaaa gtacaacttt ccagttgaaa aaagttacat tctacgtttt 74700
tagcacaatc tttccagccc gccaaagcaa cggaaagagt agttgggcat gagtggactg 74760
gtccaacgga atgaatgaca tgcgcgacct ttttcctact ctctatgcca tccctcaact 74820
catttcgaac atcccccgaa atagactttt gtcgcccttc gataacttct agcggtgcag 74880
aacctaaatc agataaggtc attaacaggg ctcgtgtagc actctgagct aaatatgagt 74940
aattactgta caagactttg gcatcacccg cagtagaaaa tttcccacgt cgccctacta 75000
atcgtccttg cttagaacga gacgtaataa cttcatcatg gcgtcgtcca ggaacgcccc 75060
cgtccgttcg aaaacagcca tgcagaaaaa aatgtctctg aatatcttcg agagttaaaa 75120
gtttttttcc aaaggagcgt acgagtgtac aaccatgatc ggatagaaag tgtttatcca 75180
ttatatatac gaattcaaac gcggctataa aggttgcagt tgcacatggt ggagaaccaa 75240
gacatttgga acataaaaaa gcataatctg ccatccatag agctgataaa ccgaaattgc 75300
gcctgtacat atctagcaca cgacaaacaa ggcattgacg atctaaggca taaacatctg 75360
cagcagtctc tataaaagtt actaattccg aatgtataac ttcattccca atatctcccg 75420
catcctccac ggtatcatca ctctgaacat cctgtatact gttgatcttg agcgcgtggg 75480
cggaaagtaa taactcgtta aaaagcgtgt cattatacat caagacgtcc ggattaaatg 75540
ccacataggg gtctttgaaa gactcctcta tccatccatc tgcttctcca gaagatcgga 75600
taaaagctgc caactctgta gggcggttgg ccatggccgg tgaaaatacc tctcgtagaa 75660
cgggttccgc acgtttggat gaagtgattc cagaattcga attagtatcg accgatgtta 75720
aaattttagc tgagaagtat cttcaggatg aacgcatata tcgcatatgg tttgaatatt 75780
taataccaga tgagatcgat ttaatttttc cgactacaga tgggaaatta aactatttgt 75840
catttactaa aagactcgct tcagccattc ggtatggtcg gatcaaaact gcagtgagta 75900
acaatagctc ctcaaattcg tatggaagca ccgagcacgt ctgcgatcat gggacctctt 75960
tatgtgggcg gagcgagaga tttgcatctg taattaatag gttcctcgat ttacatcaaa 76020
ttttgaaaga ctgttaggac tgttgggaaa taaggtgggg cagcatgatt attatataat 76080
tgtcatcgaa aaggtaaacc atatacaaag gagcgccgca tagataaaga tggaagtcat 76140
tccgaacata aatagtcgcc gtgcaggatt aatagcgcgc ataaaactta tcgtccgtgg 76200
agatttaaca actggtaatt atgatcctgt attagcagag tcattttctg gttgtatacc 76260
tacgcggagt gcgtttcagt ttagtggagc agacggagta gagagcgcat tcccagtgga 76320
atatgtgatg cgtatgatga atgactgggc caaaggcgaa tgtaatcctt acattaagat 76380
acaaaatacg ggagtctctg ttttgataga gggttttttt gatcctccga taaatgcgac 76440
taaagcaccg ctgtgtaccg ataaagtcaa tgtgctcttg aatactacag agtcgaccgg 76500
cattgtttta tcggatatca acaagattaa acaatccatc ggtgtagatt gtcgcccatt 76560
ccaggcttgt ctgattgtga actgctttgt aagattgcct attgtgcaat tggccttcag 76620
atttgtcgga cctagtgatc ctggccgaac aactaagctc cttgattcgg caatagcagc 76680
atatgatgca aaaattagac aacgcaggaa aagaaatcta caaattatgg aaagtaaatc 76740
gcaagatcat acatccgatg gatgcatccc aataccgata atcgatgaaa cgcacagaag 76800
tggcataacc ggagaatcta aaagtctttt tggtatgttt aaaaacattg ctagtggcga 76860
atgtgtgacg acgatacgta taccgcgcta catagtcatg ctgtggatat ttagtgtact 76920
actagcaatg gtcacatggg gcagctatcg tttgtactct taaacttcat gaaacaatga 76980
tacagttccc agtcctacga taacatcaga gagacatcat cgaaagaatt gtccttatca 77040
gcttcaatgt ctcgtgcatc atcccaacag gcatcgccta cctcgcaaac ctttgatccc 77100
tctgatttga gcacttatac attagatgtg ctacatcatt accctttagt ggacctgctc 77160
cagcaactca atgccatacc gaatgatctc aaaattccgg atacttattc taaagtagaa 77220
caagcagcaa gaatcaatgt tctgcgtgca atttgtgttg gatttgctga agtacgccga 77280
cataacgata atcggacctt gcaacgttcg accatgtttg cagtcaacga tgccgcttcg 77340
cggatacgac catccattgg cttgaaacgc acattcccaa cgggtatctt ttcgactact 77400
atacatggat cgccgtcaga tgatgatata tcgatgtcat aataaagtac aacaataaag 77460
tgtttaaaca gtataccgac acctaattcc attctttttt atttatccag tcaggatcat 77520
tttaattttg aaaagctcta ttgccaatgt tgcaacttta gttctcagtt gttccctgac 77580
atatacaatt tgtctcgcga cttttttgca tgcttttgta agcgcataca atgcacctct 77640
actggcattc ctgaaatctc gtctagtcag taatgcatct gcagggatca cacgagatgt 77700
actggatcca tctgtagtcg tatcggtact accagagacg tgcaaatgcg aatcgtccga 77760
atcggaatct aatgatgtca atgattcgga ttcagacgaa tggcgcatcg gtatgttatt 77820
gtatccaggg atggaattct ctttggtgtc tgtttcggtt ataatgctac ttatgtgcat 77880
atcagaatgt ttgtcattag gtgctaatcc tgtaggggtc tgatgatgcg tgtcatcatg 77940
tttcgggtat gcgacagttg cctgttcaga tgaaagatat ttcaagtcaa tagtttttgg 78000
tgacgtagaa catgcccctt gaatacatgg tggcccaaaa gaagaataat catacaatct 78060
gccacgtata gtacccgcgt ccatgtttgc ttttttatca ccggatattg tatgtgcctt 78120
tagtcgctgt agtagaggag acggttcatt ggttggagat gccgttccta ccaaaatatc 78180
ggtgattgat ctagatgaat tattcttacg acagtgcaat ctagtcgtgg gcgagccttg 78240
tctaagtaat ccagttccat ttttaaacct atatttcttc aaatctatcc ctcctattcc 78300
accatagtca ttgtttgtaa taagcgatga agaggcattg gcaatgactg ttggcgtaga 78360
catccaatcc aaatccttcc tatgctcact atacgattcc ctgggaatgg tttctgactc 78420
atgtcgatat ccttccttgt ctattaaatt atcaaaagtg actataccgg gagaatattg 78480
attaagttcc atatcatgcc gagaggaggc tgctgcagta ccagtccaat taaaagtcgt 78540
attgtaaaca gcagtatgag tattatgcat gtgctttcta gatttttcat ttctatatct 78600
actttgagag ccttttctct tatcatcagt tttcagtgtc gtataaccgt tctttacact 78660
atccggttta gttattaaag gtatagcagg cagattcgat tgacacggtt tggtttcctc 78720
ggcaatagag gaggttggag ggatcttgga agccgaaaaa gtattaggat tggggaccgg 78780
agaggtttta gaatcggaat taggaaaagg tactggaaga ggtttggaag cagaaggaga 78840
cttgggcttg ggagccggag agggcttgga atcgggagtc ggcggaggtt tgggcttggg 78900
agccggagag ggcttggaat cgggagccgg cggaggtttg ggcttggaag ccggagaggg 78960
cttggaagcc ggagagggct tggaagccgg agagggcttg gaggccggag agggcttgga 79020
ggccggagag ggcttgaaat cgggatccgg cggaggtttg ggcttggggg ccggagaggg 79080
cttgggggcc ggagagggct tgaaatcggg atccggcgga ggtttgggct tgggggccgg 79140
agtgggcttg aaatcgggat ccggcggagg tttgggcttg gaggccggag aaggcttggg 79200
ggccggagtg ggcttgaaat cgggatccgg cggaggtttg ggcttggggg ccggaggagg 79260
cttgggggcc ggagtgggct tggaagccgg agagggcttg ggggccggag agggcttgaa 79320
atcgggatcc ggcggaggtt tgggcttggg ggccggagtg ggcttggggg ccggagtggg 79380
cttgggggcc ggagtgggct tggatgaact ttcactggtc ggatcatgat cactgggaaa 79440
caaatttgaa tgtttgggga atggaggggg attcgatgag gtttcatcaa tcggatcacg 79500
atagttggga gatatatcca aatgtcctat ctgtggataa ttcatgtttt cggaaacatg 79560
gcgatcgttg tgatgaatta tgtctccagg caaaagtaat tgtacttgtg caccttccat 79620
atcatcattt tctaccactc gatcccacat gctttcagga tctatactta agtatccgct 79680
tcccatagaa tctgcatagg tatcatcttc cgagtctatt ctgttagatg atatatccgc 79740
gtcgccatcc cgagaaagat cgggagacac acatttattg tatataggac atggatatat 79800
tctgctttcg tcagaaaaga atttagacgc ttcttgtaca tcggcaatga ccatgtgttc 79860
attggccagt tccggttctt ttcgtatacc cgcatcgaca taaggcaatt ctgatataag 79920
tgcatcatcc tccgaaatta gccgtattat aggaatgggg tccaatattt ccttggacca 79980
tagaactttt atgggagcca ttcctgaatc gactattaat aaacatgggg gtgcggaagc 80040
caaaggtttg gatgcaacaa tgcgggacaa atgttccaac tgctggccaa ggcaagcgtt 80100
ttcgatcgga ttgttatcag ttatcaataa cttagttccc caagatgtca tatcagatga 80160
aacggcggtt ggttccaaaa aacatcccct agaaccatgt ctggaatcaa ataggcgaat 80220
gcatagactt aacccagatt ctgacgagta ggcttccgga cattctgctg cgattacaat 80280
acgtgcccca aataaagtcg ccgttgttgc tatatccatc gcattcactc ttaaaacgcg 80340
gcttgggggc gtggatacta ctgtaaaagt agttacattt cccgtgaggt catataaatt 80400
cgggctatcc gtgatcgatg atatattttt attttcggag catgatagaa gtgatgttgt 80460
cacatctaaa cttgatgcaa gatcaccgcg ggccgtcact acatcatcat agctcttgca 80520
attctgttct aatccgtccg gtagcaatga agaccatatt acagctaatg ctgtcggcgg 80580
tatgcacata cgcgccaata ccgttgttgt tgtcaaaagg cttgatggga tagccgcgcg 80640
aattttagca aggccatcgg ctgcatctcc atccaggtct tcccatagtt ttagaggatc 80700
ggtatcggac aatttacctt gtctccaatc ggaataacgt actgaaaata aggagccgcc 80760
tgcaggatcc catacactac ccgttaaact taatggtcta caattcgggt ctggaatatt 80820
atctttggat agttgtactg ataagcaatt cacaaacgct actgtggata tcgagtctgt 80880
cataacttca taaatagtct tgtccataaa atcatattga tcgattagat cgagctttga 80940
aaaggttaac atgtgtccgg gtatatttgc cataatggtg accattacat cggctggatc 81000
caatcgaaca acctgcttcc ctcgtccgtt cgccgcattt ttttttaatt cttttttatc 81060
tactatggga gttctccgcc cgggaataaa atatatgtct gataaattac tcctgttttt 81120
ccgcgttaat gttattgcga ttaatgcaca atatatagta cctagtgctt taatgtaatc 81180
actctgcatc caattatgtc gttttgtgcg aacatacttc gtaaaagaat agagatggtt 81240
agccatatca tgaacaaaac ccaatctgaa agtcatgata tcgcttaaca tgcctgcagc 81300
ggcttccgtt tcttcggttg ttataggctg tatagggatt tgaggtttta tccctatggc 81360
ggcaggttcg cacaaacaag cagctaattt ttccccaacc gttcgaaaac agagagaata 81420
cctcaagggt ttatctgttg aatctagata tgttaggcat ccaggactat ctatttcaga 81480
aaaagcttcc tgcagtgtag ctacgacttt tggtctgatc caacttgcaa ctctatgttt 81540
taagtatcta tttacgactc ccacgtttga tgtgtgattc gctccattgt ttgcatctcc 81600
tgcatcaaag ggcagcaaca tcggatcgcc gacattcccc tcaaatgtgt tcgaatatcc 81660
agcatataaa gccagtctta atgttaacaa ccgcgaatat cttgctacac gcttggtgta 81720
ccattttgga agacgtttag cgatatcctc aaactgtgta tatattttct taagatcatt 81780
tatggcaaag gttgacggga tcttctcaca caaaccctcc atttgttttt gggtggcctc 81840
tatttccttg actgtggtaa ggaaggcgtc aagaacgacg accctgtctc ggtacttggt 81900
atcaatcaac cctattattt tagccggcag tctgggatat tccgcattac tacgcaaagc 81960
atttatcata ttcacagata cttttgtccg agcagcactt tctcgagctg aagaaaatcc 82020
ttcggaactc ttaccaattc tatctttatc atgtacaaat gtggcccatg tatcatccca 82080
agcaacttca gccagcgcta gttcagattt taactcttcc aggcgttttg ataaattaac 82140
taatgcatct atccggtctg catatattga cataggacca ctttcatcta tcctaacagt 82200
caaatcatga gaatctataa ctgattcggc atgtctcaac cattcaacag tttgcgagtc 82260
caactcttta gtttcttcga ctttagttaa aagcagtgct gcttgagtga cgatatcatt 82320
tacggtctct gacctatcaa tagccttggc tatatgcgat ggcatcgaga ccagtctcaa 82380
taggttttta agattagcta aaagttccgc agactctctg tctgcagcat aagatgcttc 82440
ggccaaattc ttcagaatag cttctcctct cgtctttgca tcttcaatag cagtggttac 82500
tcgatgtatt agtgaggtca ttgcatcagt atcccgtcgg agtaaatgag caccatattc 82560
tgaatatgct gtcccctcaa gctcttctac gtgatctttt ttcaattctt ctgctatgga 82620
cattatagtg tttacagatg gaattataat agagacccca tattctagag cacggcgagc 82680
tccctcgggg ctgtgtgttc gggccaagtc ctctaatgcg gcacttattt ccaaagcaac 82740
tcttcctgat gcatgatgcg cctctactct tctttgctca aggtgggcca aaaaactcat 82800
aaatttcaca tatccgcttc tataaaaatt cacatatttc actaaattgg gataagattt 82860
cagagcagac tcaagttcgc ccattaacaa ataataatcc acattgcccg agtttgcatt 82920
tgcatgtctt agaatagcaa ttgatatatg aagcaaatcc attacagtat cgcaattgac 82980
accaaagagc tttgtgtagt agggagctgc ggtcatgaaa gagtctcccc acgtaatgct 83040
ttttaatgcg gctataggag gcgaaagacc gtgtaccata ttttgtgttg aatatggatt 83100
aaatttcaat acagattcta tcgaactttc aagtacgcga gcatgcgcaa taacaatttt 83160
ttcggctctc gatttataac ggatagtgtc ataaccacct gtcctggcgg catcttctaa 83220
tcggtttatt tccatagcat caaattctga tttcacttca gcattcaata ataaagaatt 83280
gattgaggaa atccataagt cttcgctacg tgatctctca gcactgatac gattgtgctc 83340
atacgtctga atagctatat ccaattctcc agctcgctga tttgcagacc ttattagttt 83400
tgaaagttca gctatcttgc gttgtatgtg aggatttgag gtgtatgtca gaccttcaaa 83460
agtagagagg gttgcagtaa cattacctac agtttggatc gcattagaga actcaacttt 83520
agcgctcgcc acaacactgg tatcattctc ggaaataacc tctctgggat ttaaacttct 83580
gatcttatga ttcgaagtaa ttagattatc aagtatagtt cgcaccgact ggataagaga 83640
ctccaaatgt tgtccacgat ttgctacgtc cgctgcaatc tccgcagtgg ataataaagc 83700
ctttagaaac aaaaaggcat cgctcctttc tgtagatgaa atgctcatta ttccctgggg 83760
aggggcgatt gcattggccc tatctatatc tgatatggcg gcttttaatg ttgaaactac 83820
ggccatcgtc ttttcgacag acattggttc aacggctgca gcagcgattg ttgccgaaag 83880
tacatcggcg tgctttccaa agaagactga tgcagcggga tagcttccct gtggaccaaa 83940
tactaatcta atagctagtg caaatggaac acctaaacca gataattctg ctgctacttc 84000
tgtagtaggg cgggataata ttgttttata ttgaataaac agtacccata aatctgattg 84060
gagggagcct attatgtcag atggagcaga agctaaaaaa ttttcgaaag aacccatccc 84120
cctaggaata gattctgtta tgacttttac ttttgaatcc agagcacgta acccaacaaa 84180
ttttggcaag ggacgtaata ttttgcgaat tgaggaatat aggtcttcga ttgtcgattt 84240
cacttcctgg taccgctctc ggagatgtgt aataaaagtt tcatttttac gacgcgtgtc 84300
tcggagtttc tcccgcacat cggaacttaa cgaagttgca tttttcttat cttccaaaac 84360
tatagccaat ttaacaatgt cttctccaat tttaatcgct tcgtctagtt tttgtagttc 84420
tactgtcgtg tccaaatcgg tatatgaacc aaatctagtt tccagctcat ttagacgttc 84480
tagttctgtc agcacagttt catggcgagt tgccttctcg ttcacaatat ctatctcttt 84540
catcaacata tctaattctc gccgactgat ccaaccacca acttgcattg atgtcattaa 84600
atttttccac gttgttagtt tttccggaac gtctaaatcg gaaccaattt ctaataaatt 84660
cccaagcagc tcagattcga aagcctgtga tacaggtgat ggtacacgtg cgttactacg 84720
tgatgctatt aacaccatca cgtcatctat cacagataga gaagatgcaa atctgtttat 84780
tttttcatat tgatctgtaa caactatttt aaatcttgat acgtcgctcg agctggcggt 84840
aagtgctttc acactataca aagccacctt taaatagtat tcccggagtg aatgaccaac 84900
gacatcaatg acggtttttc ctatatctcc caatctttgt gtaacaacag ccgatgaagt 84960
tttagccaca atgtccgctg catctatcat aggactactg cccgatcctc ccattataaa 85020
cgcgtctaaa gttgtattca tccatcgaac acccgcctca agtgcttcca tttctgctag 85080
gattaattca gcctttcgaa tagcaacggc ttctatatcg cgtattaatg tacacagtga 85140
tataactctg tcagtcaatg tttgattgga attggaagac gtcttttcag aatacaattt 85200
tccggagtta tgatagagtg tatctaccaa aatggcggcc attctttcat agattccata 85260
aggatcagcg gtacccactt ccttttctat agcgtccaaa gatttatgca gttcatcggt 85320
gacttcttca acttccaatg ccactaatat catcttactt aaagctaagt ttcctatctt 85380
ggaattctcc gcaagaaccc tttctataag gtctatagat tcagatgctt cagaaagaac 85440
cattcctgta gacgcgatga aagtagtaaa atagacaggt attgtaaagg ctttaagtaa 85500
cgccgccatt tcatagccta caacggattc tctatccgat gtagttctgg ccccattctc 85560
tattatataa ttaaataatc tggcaaaaat atccatcatg catacatata ataatccccc 85620
atcactatca tacggacttc ctacatggac tataattctc agtcctgaat ctatagaaca 85680
tgcaacatcc tctattttat cgcggatgtc agccaaagga taatgagata aatattcatc 85740
actccacaat cgatcttgca ctaatccatc ttcatcttct gtcaacgatt taaaattaaa 85800
aagtggtcta ttttttaaca aatgttcaac tgtggtatct tctccacgat ttgaagtagt 85860
tggcgatgaa cctaaggtcg gctcatccgg tatattagat atgacagggg ggtaagtgtc 85920
tacattctcc gtcacatctg acgattctgt agaagtgacg gcttctacaa ttctagattc 85980
cagagttcgt ttagattttc tcgagtgttt cctgctcaac gagctgcttg atccatctag 86040
cgatatattt tccgaacttg attgtggtgt ccataaagga cgacgccttt tatgtctcgc 86100
ataattccgt atgcaacctt cgacagatgt tgtacctatt ttattttcag ctacttttgc 86160
aaatgtgccg aacgaaaatt ggaagttggt ttttggtggc ggatcctcga taacatccga 86220
aaatacaccc tgccacgcgg tcactgaaat tgaatcttta gtggatggat caacaatagt 86280
gctatgggta tcgtcaaggg tttctcctgg gttctgaata ttgatgcaat ctcgacagtc 86340
tttggtcgat ggaggtgcca cagattcggt attggtagga gcatcattgt acgaaagatt 86400
atgatcgagt ggtctggaat cctcgccatt taaatcttct gcttgtatgc aaggataatc 86460
tgaaccttgg atagttgtat ctgtactacc gatgacaagt ttggttaatc tcggttgtgg 86520
cctagaaggc ggatcaaaat ctgccgacac tactttacgg ttatcttcct ctctagctcg 86580
acccaaatct aaaactatat cggaggtccc atagatccgg gaaacggtcg atattatctc 86640
gtctctgggt gggcagatag aaaccgttga tacaaagtat acaaatgttg cagaccaatc 86700
gggtgttgcg gaggggtcgg catacgatgt gagatattga taaaaataac cttcacttac 86760
acggactata catgcctgtc ctatatgccc atgtccatgc ggatcaaaaa tataaattcc 86820
atcgccggat ctgtacactc caattcctaa aacgccaacc acaattaaac aataaacatc 86880
accccgcttt tttttccata tttgttctat gaacgtccgc gcagatattt gagtatctaa 86940
tatagtgggc gtgttttctt ctagatagaa ttcaaactcc ccatatgaac tcgaaaatgc 87000
aacacacaaa tttcctcctg catcttttga tataattcta ttcggcagat catgcggaac 87060
acacgttgta taggtcccat cttcagaagt cgctattgtc caggcctttc cctgtaataa 87120
aagtctatct attgcatctg atgatatgac tgtatctaat ccatacgcaa aaactatacg 87180
aagaaatgcc aacgatgaac gtaaacatga aactgaagac gcaggactta ggtccggagc 87240
aaactggttt ctaataccaa ccgccactac cgttacatca gtcgtatcta tcaccatctt 87300
tgcccattca tctagaatta cctcagggtt atccataatt tgcccaaaat atgggtcgtg 87360
ttttcgatca agcgaacaga gtccagacgt cgatttatct cttaacacgt tcgcagctag 87420
catgggtgcg ttcgatgtcg ttcttgaata tttcctgcaa tttgtagtag cttgtctgct 87480
gtcagtagaa tctgtcattt tacactcaat ttatatgatt gaaaatatgc gtcgaaacga 87540
cattagctcc actgctgcca taaagtattt atacaagtca tatactgggc tgaagttaaa 87600
ttcggatatt tgacgaggcg caacgttcca catcaaacgt aactagtaca actacgtcgt 87660
ccaagacggg accgttgaca taaacgcccg gatgtggaga atagatttca tattatgcat 87720
tatcaccgtt tgccctccta ccagtattaa acacagtatc tataatattt acgagagcat 87780
ccgctgttac tctttgttta gtaatgaaat ctctagcaaa actagtcaga tctacatcat 87840
ctggagctat agtttcgatg tccagtgtac aaaagtttat ttcatctcgg tgtgttaaat 87900
tgtgtcttga tgacaaggta actacgagtg tagtgtcatc ctcagttatt actgggtagt 87960
cccgcatcac agattctacg gcaaattcta tttcaccggc cacggattta tcatctgtac 88020
caatcgaggc cagatcatgg tccatcatat cttgcaatac tcctcctaca ttttctatag 88080
cactgaccaa ttcatgcgaa cttctatcgc gatatgtaga attaatttca gatagtatcg 88140
accatcttcc caaaagccaa caaatgtcct gcattcctgg tggagtatta catgatgtca 88200
acttcctaat gtgcagatcc agtgaatttt gcagacgtgt taaaccagca aaatcggccc 88260
ccaacacaga aaaaagcttc acagcatctt ggcctaatgc atttgcttgt tccattatat 88320
catcacataa caacaattgt ttcccagttt cttctataat tgtccgcaac ttcatcgagt 88380
cgagtctaat gtctgctata atgttgtttg ccgaatcata aagctctcga atagctgtca 88440
taacgtcaaa gattttccag gttcccaaag acgaatgcag ttcgctatga tgataaagct 88500
tgacagtccc cccagatata ccagatacaa atttgcaggt aaaaaagtct ttaaatatcg 88560
atgcaaatac aaccagttgc ttggatttat tggataaatg ttccacacaa tcaaatgtac 88620
gttccgccaa gtaattcaat tgaagatgca atgccgttcc gtgcatacta attaagacat 88680
tgctattcga cgggtctggt cgagggggta aaaatggtct agcttcctgg ggtaacatac 88740
ttatagcgac actaattaca tcgtataatt ctcccaaaag catttctata ttcaatgcat 88800
catcggtagt aggcgcattt gatatgtctt gtgtaaacgg aataatcgca gaaatgagag 88860
cgtttagttt accccggtga tttatgaaac tgtctaaata tggcatacca taatctctag 88920
cccaggttaa gacttttaaa gccgtaccta aacgaggtgt agaaaatata gctgtcgtta 88980
cacttgtaag tgcatccaaa cacacagtag ctataatata tttcaagaaa tgaggggttg 89040
tgctttcagg tgtgattggc atgggttcgg gataccgaat tgtactagcg agacgaatca 89100
tctcactctc acgttcccca tcaaattcat cctgctcaac attgctgtcg acattagaat 89160
aatcagagtt gggcaaattt gcatccaaat ttaacacatt tgactcgtct ggtggaacaa 89220
taccccagat ttcattggct cgattgtcaa accataacat gagtgactct tttgcagacc 89280
ttattgattg gtggaacccc accgcttcac tcttacttgc gacgtgatcc atttcagcta 89340
caaggactgc tcgcgcagct ttaatgtaat cctcatgggg gatcggtgga atgcatcgac 89400
ctattatttg agatattatt gcccgttcta aacctaatgc ttctataaag tgggaatcag 89460
attcggaaat tacacaattc tccatataat tggataaata tgtcattccg ggtccgtagc 89520
tttcaatcaa cccaaagacc acgttaccga tgacggcaac gcatccaact acctgttgta 89580
catcatcaaa aatatcacct tcatccacag agccgtaatt tcgcgtaaaa tatgttttta 89640
gtgctgattc atacgcacgg catacctgtc gtacaaaccc acgctctata agtgcctcca 89700
ataattgttt aggagatgaa ctgtattgga tagcatccca agcccgtctg gcagaattgg 89760
aaagttttgc tttggccgca tcaatagcac cgttatcttc ctctaaacca atgtcggaaa 89820
taagtctgag tacagcagat aaatgaattg ctaatgaatc ttctgtcaat gaggtatccg 89880
acataataat atccgacccg ttgcgcaact tatcagccgc catgccaggt tgtatcgtgt 89940
gtacaaatgg actttcatat gctatggcgg cagatgctcg aacttcatac gatgtgcgtt 90000
tagtactatt cgcttccaag gcagggataa gttctttcga acccaatgcg ccaacatctt 90060
ctgcaaagcg atcctttatt cgaaagggtt ggggggcatg caatcctcta aagtattgat 90120
ccaccaacgc tattgtaaag agtatccgtg taaggggcgt gaaaactcta ttcgttgtac 90180
atctatacat gattacaaaa ggggcaatcc aaccactggc tatagatacc agtcgaatac 90240
cctcttgaac aaacggaaaa tcatatatga gttcaaaacg tttatgtgcc aaagaggcgg 90300
ccagatcccc tacattaaac gaaaattctc gctcagaaag taaatgttct ggcgtatacg 90360
taaaagcatg attggcagca tcctcaaaaa cagcaaacca ctcacttatt aaaggccaca 90420
taacactcgg tccaaatgga gctgatatac gtaaattgtt ccgactaagc caagaaatag 90480
cttcttctcc cgtcatttcg gccaccagcc gacgcaaacg atgggaattc tcttgccaag 90540
aggtcttatc ccacctgaca gatatgcgcc agagaattaa accgacgaaa ttttgtgcca 90600
acattgatgc ttctggactc ctcgtctgtt tatacacctc gagtatggca gaaaatgtgt 90660
cacgccatgt caattctact tgcagaatac tcattgttcc cgaagctaga aaaaaggatc 90720
caatagcggc tcttgcctcc gcggttgcag tagcacccca tggttctgtc ggcgacgttc 90780
tcgaagataa ggaccgtagc gtgtccaata aaactttcag tggccatatt tcatcggtcg 90840
ttacggcaga cattattcag gcaactatcg ccaaccctct gttctcccta gatgcgatcg 90900
atattagaaa gatctataaa atgtaatacg gctttcaata ccacaactcc taaaaccagt 90960
cgtgattacg tagtatagtc atgcccattt cagagaacat acaataacac agtaaaatcc 91020
tactaaatat tgtatctgca ctattacttg accatgccag agtaaatcgt catttctatt 91080
atcgccacac aaacgacaac aatacataat acgcctcaac ccaacgtatt atctgcaata 91140
tcggagttat ttacagccat tgccgaacac gggacaatat ttttactagt agctaatttc 91200
gatttccgtc aattatctac atcatgaaac cactcttacg atcgcacgaa acacaatact 91260
acagtctgta tcctgacacg ctgaacggat tacacaacgt cttccggacc atcggaaatt 91320
ctgttcaatc tgataccgtt cgacgtctta acctaggcta tctcgatggg gacaacagac 91380
gaggtaattt ggcgggtgga ttggaattgt tgcgcgatgc aaccgctcca aatgcatccc 91440
gaatgaacat aactcgccct ctcgatacct caacgtctgg cgcaactgca atgattatgc 91500
aatctctgcg tacagatgtt gccgaaaaca tcactttact tacaggcgat agtcgagcta 91560
caatttcccg acaagttacc ctaacagatt tctgtttccc tgatgccgaa atgccaggat 91620
tgataatatt atctattcga cacccactag atataaacag tgaagccctc tacgctactc 91680
cagccggacg tgatccgcga gtcatggaaa ctgtatggta cgaattatcg gagttggcag 91740
cagtatcagt aaatagagta aacgggagtg gagtccggcc ctccttagta tctctttcat 91800
ttctcatcgc tgcccgcgca agcgactacg cagataagtg cggggccgaa gcactaagag 91860
cacatgttat tagtaattat ggccgacggc ggatggaaga aaaacttgat agattcggaa 91920
tttgtttaat caccatgtta aggtgtcgcg tatttccaca cagacacttt cagctattgg 91980
gaggactgat ttcgtggatt tcgcaacgcg aaattgcaag cattactgcc gtggttagag 92040
ggccacagga aagcatcaaa acagagcaga ctgccatgcc aaggtcctcc gtatatgttc 92100
ccgcatgtgc ctatatcgat tttgataaag atatacgggt aattcacgag gaaaggtctt 92160
catcatctct ataccttgtg ttcgtatata cacaaaaatt cgggcgtgaa actgttcgga 92220
tatatgtcat gcgaagtcgt ttgggggagt gggcattccg agaagggcta ggttacatgt 92280
attctggagt gcggtccaat aacgctatta ctggtgtgga tggcctgata gtgccacatg 92340
gggcaaatgt aaatatggaa tttccattaa cgaaaacact tgatctccgc aaccgcgatc 92400
gtaggttggg tattgcagcc agatctagag atttaaataa agccgactgg aaagtagatc 92460
tacgtggtcg tcccacaaaa gaatcttgca tgtatgctgc atattgtcgt ttgggacatt 92520
tagatgaaag ttcggtacca gtcaaaaaat tcgaacgttg tggatcccta gatatccccg 92580
ttatatggat accgggtgta atttggaata taggtacatg gatcgaatgt tattaatgat 92640
aaatatgcaa tcttgttgat atataaccat atttaataaa ggcgatcagg cgtacgttgt 92700
gcataaatat gatttgggaa tgattcatgt gttggttggg gaggagttca caatataaaa 92760
gtcagagtct ggcggtgagt tactttggtc acggttccgt taccggcgcg cattcgacaa 92820
attatacggt catccactct gcgactaaaa atctgctatg gaccattcag atgtctacga 92880
accatatact ttctcaggga aacatcacgt tagaatgtac gacttctcaa aattaacacc 92940
gatgtggaat aaagatgcat ataccccacc gcgtaaattt gccgatatgc atatagcatc 93000
gactgtagcc atggaattgt ataacattga acgggaactt ttgaatatgg gccacttatc 93060
tggtatggag acaatgatgg tcgacgttcg aaaatctcct gaaatgattc cgtcgacaat 93120
taatatgcga gaccatataa cacgcctagt aaataagatg aagcctatct gccgatttga 93180
tgaacgtctt tactccctct gcggagaatt ggttcatttg cgaatcgaat tacgcgaagt 93240
tcctctagat acatggctgc tgtcaaaaaa gttaaacctt aagtatgaag ttgtagataa 93300
tatacggcgc tacagagcac atattgagat ggatatgctt cgtttttatg ggagtatcca 93360
tccctggctg aaacggttag gattacaatc agcattgaaa tatgaagaat atctcgtaga 93420
attggaagat gggaaaaaag aatccctgtg tcaattcttc gttcgattgg cggcggcagc 93480
tgcaacggag gcgtcgatga aaaaaccttt tatgaccacc ttaacaacgg gggtagcaaa 93540
ttggagaact acattcacaa cttttttttt ggcactcgct aaccagctat ttgtgccgtc 93600
tactccttgt atgcttttcc taggacgaga aggaacctct actgcgagct gttatcttat 93660
ggatcctaga actaataata cacaagatac acttaaggca attaccgagg atgtagtacc 93720
ccatcttctg gcgagaggag ggataggtat atcgttgcaa catttaaatg ggaaatttgg 93780
tcttatgcac gttatgaaag tattggattc gttagttatg gcggcaaatg taaatgaatc 93840
ccggcccaca ggcatttgcg tgtacctgga accatggcac gcagatatta tgtcagctct 93900
aaatatgcgt gggatggtgg cagcggagga atctcgcagg tgtgataatg tgtttcttgc 93960
cctctggtca tgtgatttac tttttaaacg atatctgaga catgtaaacg gagagaaaaa 94020
tgtaatatgg accctgtttg actcccgcgc atctatactg accaagctcc atagtgaaga 94080
attcgaaaag gaatatgaac gtttagaatc agaaggcttg ggtgtcgcta gtatccccat 94140
tagggacatg atgtttgcaa taatcaaaag tgcagcctct acaggaagtc catttattct 94200
tttcaaagat gcgtgtaata gacattatat tacaaacacg caaggagatg ctatagcagg 94260
gtcaaattta tgtaccgaaa taattcagaa aaccgatgct aacacaaatg gggtgtgcag 94320
cttggcgagc atcaaccttg ccagatgtgt ccgcaacata gatggaaacc gccaatttga 94380
ttttgatgct ctcagatatg ctgtgagact agctaccgtt ttcgttaatg ccataatgga 94440
aggaagtgat gtaccgacgg aaaaatctca ttctggccga gaacgtaaca gatcgatggg 94500
catcggcgtg cagggctttc atacagcttt tctatctatg ggtcttgatt tatgcgatga 94560
acgcgctaga tccctcaaca agctaatttt tgaattcatg ttattggagg cgatgacagt 94620
tagttgcgaa ttctgcgaac gaggcctgcc gccgtttgct gatttctcta acagttatta 94680
tgcacgagga cgtctgcatt tcgatgggtg ggctaatgta gaattggctg cagtggaaga 94740
gtggaatatg ttacgagata gaatagtgtc cgctggatta tacaatgcac agttcatagc 94800
tctaatgcct acagccgcgt cagcgcaagt cactgaagtc agtgagggat tttcacccct 94860
cttcagtaat atgtttagta aagtgacaag tacgggagaa ttgttgcgcc ccaatattca 94920
gttaatggaa gaattaagaa cgatatactt agataatgaa aatcaacgat tggccacaat 94980
tgccgcatta gaatccgcaa actggaacat acagactgct ttaggaaata aacccgaatg 95040
ccattcccta cttaaataca aaaccgcctt cgactatgac caagccctcc taattgatct 95100
atgcagtgat agggcaccat ttgtggacca gagccagtcg atgactctgt ttatcacgga 95160
aaccgctgac ggtacgttgt tggcatcacg cgtcatgaac ctgcttctac atgcatataa 95220
ggctggtctc aaaacaggga tgtactactg caagatacgc aaggccacta atgcgggagt 95280
attctgtggg gacggagaat tgacctgctc gtcgtgcgtc ttgtaagatc ctgacacgtg 95340
cacagtaacc acatcattct tctaaacgca cagaaaatat gagcggccct ccgtcacatg 95400
agatcggcat gctatacagc cttgctccat ctgtagatat gaagtccgaa aacattgaag 95460
acttgccatc ggaaagcatt cctaccacca atcactgcgc atcaaattac ttctatgcac 95520
ccgaatgtcc ggatatagga caccttcgag cgttgagtat tatgaatcga tggacggaga 95580
ccgaatttgt aatcagtgac gatcttagag acgtttcaat gcttaccgag gaggaaagat 95640
atttctaccg atttcttttt acttttttat ctgccgctga cgatttagtt aatcttaata 95700
tagataacct tttaggctta ttcagccaaa aagatataca tcactattat tttgaacaag 95760
agtgtataga agctgtccat tcgcgagcct atagtataat ccagttaatg ttattcgaca 95820
atgactcact ggcacgagca gaatatgtta agacttcctt gaattccccc gctatccagt 95880
ctaaactaga ttggttgaat aaacgtgtca tcgagtgcag ctcaatagcc gaaaaatata 95940
ttcttatgat cttaatagaa ggcattttct tctccgcatc tttcgccgcc atcgcctatc 96000
tacggatcaa caatctattt gtagttacat gtcaaattaa taatttgatt agcagagatg 96060
aagcaataca cgtagaagca tcttgctgta tttttaagaa ttatctcatg gggcccaaac 96120
catctatcgg tcgtgttcag gaattgttta aagaagctgt ccaaatcgaa tgtgcatttc 96180
ttcgcacagc tgcaccacgc aacagccagt tattggatgt tgaagcaata tgtagttacg 96240
tacgttacag cgcggacaga ctactgaaag aattagatat gccacctatt tacaacgaac 96300
ctaaacctac agctgatttt ccgctagcac tgatgacagc ttcaaataat accaacttct 96360
ttgagagaag aaatactgca tactctggaa gcgtgtcaaa cgatctttaa tttgtctaga 96420
ttttcatcat gtcaatataa caatattaat aaaattatca gtcattagat cgtgttgtct 96480
ttaatgcatc gttcccccaa tacttcaaca atatatgatt aagagggcgt acctccggta 96540
tacgttttat aaattgggat acgatagtgc tagcttcatc tacatcaaat atgttgcaaa 96600
agatcaagtc ttcaactgct gtctcatcac gtccctcttg cattataggg aagcgtttca 96660
aaatactaac cctggaagtt ctgcgctctg ggattatagt agcaatgaca tgcttaataa 96720
atttatactc tagaatttca catcttgttc gaggggggcg taaagatttt agcgcttttt 96780
gtacacctct tataaggtta gtatccgtgt agttggaaac atcattatcc caacaactcg 96840
tttttgattg atctttgcga atatgaagat caaaaccttc agaatggtaa gagttttccc 96900
cagtccgccg atcttgctct tcgtatagag gtctgataca cctaggaaca tcgtcgtcag 96960
ttgcacaatc cgtatcgtgc aaacatcgtt ttgctgacga aagattaatt atttcttgca 97020
ttgattttag tgtaggctcg cgatgtaaat ccgtatgaca gcgaacaaag tttaacaaaa 97080
aagtgaaata gtccatttgc agagctgcta aaacatctct gcaataaata gttggcggga 97140
atatccgtgt gagatcgata ataatatcac atcccattaa tatcaaatct gtgtccgaag 97200
acaatacata tgcgaccgtt tttgtatgaa acaggttcgc acagatatca tctgcttcca 97260
ttgtaccggc gtccacataa ggatatccca tataacggat tatactcatg caaagttgat 97320
aaagtatttt cggggtttca aacctttcgc tccatctaca aaccttcttc ccggggtgtt 97380
tcctcttaca ccgcgcctct ccaacatccg tacttccaca ttcatcaaac aatcgtgcat 97440
gtagtcgccc agaacctcct ctattagcaa tgcaagtggc cgctatcgct ttagcgccgt 97500
atagtgtttt tccattccca taaaatcccc gatctgctac aaagaccgga tagtatgatc 97560
gctggtgtaa caaacgcaga agacaatata agcaccgcag tgtaattatc gaatcgtcga 97620
ctccgtcgat ctttcccgga tatagttttt ctaacaatcc atacataaca ttccataagt 97680
ctacgacaat aggtgtcata tcccccccgg atataaagcc cgatatatga cttctcacta 97740
acccgtttgc atatgcaaaa ttcatacatc catatactcc catgatgacc ctcgcagttt 97800
ttaaatataa cctaaataga aacctgaaat tatcacaagt actacagttc tgtcagatat 97860
atcctaactc ctaataacaa agtacacgtg aaataggcct aacagtgaaa cgatatactc 97920
ggttactaca ttaaaatatt aatcggaatt acacttctga aggatctggt tcatgtaaat 97980
cttaaccatt ctatatagca atatacggat tctatattgt cctataaata agtaaattgc 98040
atgttttaac ctataattaa ctcgttatag gtagacatga ctcatactag ggttgatttg 98100
cacatagctt agccagatgc agtaaatata ttgtcacgtg gctaaaacgt gagtagtaac 98160
ttatatggcg aattaaactt atatccaatg gcgttcgcgg accttcacac ggaaacatgt 98220
gtggtgcgac attcaagtgg ttatgagcgt cagttgaacg tagaacatgc gcattgcaat 98280
tatgtcccag aatcctcccc catataaatt cgtctactga aattcaagag cacttgctgt 98340
attacttcca cttcgacgaa caacacacaa gaccagtcag ccgcgaacgg aaataacgcc 98400
gaatcgagct cctctaattc cgataaccgg ctgttgtcaa tggcaggaat aactatgggc 98460
agcgaacaca tgtatgatga tacaacgttc ccaacaaacg atcctgagtc ttcatggaaa 98520
attgttttgg ctggagagaa atttatgaca gcatcggctg cattaaaaac aatagtaggt 98580
tgcgtgaaga acccattaat tacatttagc gacgacggac tgatgataca gggcacggtt 98640
tgcggtcaac gtatgtttgt tcctatcgat tgtacttcat tcagtgaata tgaatggcgc 98700
gggcccacag caatattcct agctcttacc gattctagac gtaccctctt agatgcattc 98760
aaatgcgata agaaaaaagt agtagaagtt tgttttacct ttcgaggaga accaccatgc 98820
cgacatctaa cacaaaccgt cacatatgca aatgatggat gctcattttc gagtacaatc 98880
gtcaaatatg aattatggag cgcatccatc atttgtcctc aaaaaactcc agatgctaca 98940
ttttcattaa acaaacaaca attgagcaaa attctaactg tagctgcaaa agtacaacat 99000
gaagaattga tctttgcttt gaaagctgaa ggaggttttt atgccggaac gatttgtgat 99060
gtgataagtt ttgatataga tggaagcgca atggtccaat atccctataa tgcaacaagt 99120
catgcttcgt cagccctcat cgtggcatgt gggaagaaaa aaacaaataa aagtatagct 99180
gtaactgcat acggcagcgg gaaacctttc tgccttgcac tggaagatac taacgcattt 99240
agaaatgtcg tgcaaaaaat taaaacggga gccgctgggg cggatttggg attttataca 99300
acgtgtgatc caccgatgct gtgtgtacgt ccgcacgtgt ttggaagtcc cacggcattc 99360
ctgttttgca attcagactg tatgtcaata tacgaattgg aagaagtgag tgcagtatct 99420
ggagcaataa agtcgaaacg catcagcgaa tatttcccca aagtatcaaa tatcggctcc 99480
cggaaacggg gaccatcttc accccccttc gaacgagaag ggaaacttgc caaagttatc 99540
aaccaatgag actttcgtga ggacctgtaa gtatgtcatg gagtgggagg gttcatttat 99600
attgcatgta agccttatag aggatacacc agaaactcat agttgtgcca attcaaacga 99660
caccgttcat ctgaactaca aaacagaata ccgctatcaa attggaacat ggattctgtc 99720
aacaactcat cattacctcc gtcttataca accactggta gaacatatgg acattgtctg 99780
caaatgctca catgcctcga gccaccgtgt acagcaacaa atggaaacgg aatatcaaac 99840
aatcgatgtc taaaatgtat cgtagtaacc atgtgttcga tattctccat tgcagctcat 99900
ttggctatca ccctgtcatg tataaccttg attcaattta ttgaccaaaa aattatctat 99960
ataaactgta ctatttatgc tatcaccgga tttctaattg ccttcatcgt gcgtcttacg 100020
ataaaatcgt cagaagtgct gacatcaatt ggcaaaccgg cacaatttat atttgcttta 100080
atctcatcca tagcagatac gcttattaca agaaatatgt taattgacag taatccatct 100140
tatgtaaaaa tattgagagc aatagagatg acatctttga tgtgctttgt catgcttgga 100200
gcattcattg catcctacca ctatgtctgc ttggcaacgt ctggagattt aacttggaaa 100260
gctgggtttt tgatattgac cgccggaaca attatcggaa tatcagctcc atatggaaac 100320
atttcctccc tattcggatt tctatttcta tatactatat tagccataaa cgttgtaagg 100380
gatgcaagta aagcactgat gaatacatgc tattatcgca tttgtcgtgc aacaactcta 100440
cgccatccct ctcgcctcgg ctgcggtcgt atgtcctcga ctcaagatgt caatgcaacg 100500
catgaagaag ccatatcaag cgcagatacg attgatggtc agattcctat ggtagttatg 100560
agccacgcga caggcgtatt aattccagtt gttattgcct tgcagaggta catgacaaag 100620
aagactgtta gtttgacatc gactgatatg ttacagggag tctgtggcgt tttagtgggg 100680
gcgagtgttt caatatttat cccgtcacgt cgcgacgaaa gtttatcccg tccaattatc 100740
attttattgt ctataatagg agcaatggcc attactttgg caggttttgg tttggtactc 100800
gggccaactt tattttccgc atgtgcagca gctttgtcat gttatacctg cattaatata 100860
aggaatgcaa ataagggaat taaacaatta gcagctgcct atgtagtgaa atctatactg 100920
ggatttatca taactagttt acttgtttgt atattagtag cgctatcttg accaaatcgt 100980
tgttcacatc ttggccatat acgtattgat cgttgtttcg aaccgcgaat aaaactttca 101040
tacatactaa acgatggagt tgtgttttat gagcgttgaa aacaaaggta ccatcggttt 101100
aaaactaagt tgcatatcgt aatccacaaa aatcatttta tacatcatcc cgaagagaca 101160
ccaaacgtaa ccctctacat atcttccctc atgctcacgc cgcgtgtgtt acgagctttg 101220
gggtggactg gactcttttt tttgctttta tctccgagca acgtcctagg agccagcctt 101280
agccgggatc tcgaaacacc cccatttcta tcctttgatc catccaacat ttcaattaac 101340
ggcgcgcctt taactgaggt acctcatgca ccttccacag aaagtgtgtc aacaaattcg 101400
gaaagtacca atgaacatac cataacagaa acgacgggca agaacgcata catccacaac 101460
aatgcgtcta cggacaagca aaatgcgaac gacactcata aaacgcccaa tatactctgc 101520
gatacggaag aagtttttgt tttccttaac gaaacgggaa gatttgtttg tactctcaaa 101580
gtcgaccccc cctcggatag tgaatggtcc aactttgttc tagatctgat ctttaaccca 101640
attgaatacc acgccaacga aaagaatgtg gaagcggcgc gtatcgctgg tctctatgga 101700
gtccccggat cagactatgc atacccacgt caatctgaat taatttcttc gattcgacga 101760
gatccccagg gcacattttg gacgagccca tcacctcatg gaaacaagta cttcatatgg 101820
ataaacaaaa caaccaatac gatgggcgtg gaaattagaa atgtagatta tgctgataat 101880
ggctacatgc aagtcattat gcgtgaccat tttaatcggc ctttaataga taaacatatt 101940
tacatacgtg tgtgtcaacg acctgcatca gtggatgtac tggcccctcc agtcctcagc 102000
ggagaaaatt acaaggcatc ttgtatcgtt agacactttt atccccctgg atctgtctat 102060
gtatcttgga gacagaatgg aaacattgca actcctcgga aagatcgcga tggaagtttt 102120
tggtggttcg aatctggtag aggagctacg ttggtttcta caataacatt gggaaattca 102180
ggaattgatt tcccccccaa aatatcttgt ctggttgcct ggaagcaggg tgatatgatc 102240
agcacgacga atgccacagc tatcccgacg gtatatcatc atccccgttt atccctggct 102300
tttaaagatg ggtatgcaat atgtactata gaatgtgtcc cctctgagat tactgtacgg 102360
tggttagtac atgatgaagc gcagcctaac acaacttata atactgtggt tacaggtctc 102420
tgccggacca tcgatcgcca tagaaatctc ctcagccgca ttccagtatg ggacaattgg 102480
acgaaaacaa aatatacgtg cagactcata ggctacccct tcgatgaaga taaatttcaa 102540
gattcggaat attacgatgc aactccagct gcaagaggaa cacccatggt tattacggtt 102600
acggcagttt tgggattggc tgtaatttta gggatgggga taatcatgac tgccctatgt 102660
ttatacaact ccacacgaaa aaatattcga ttataatctc attgttatgt agttgtgatt 102720
tattaaacat attttttata actctagtat tctccgagtt acttatatat ttatttgtca 102780
gacaataatg caatagtgga gaaacgtgag gggagtctgt aaacagaata cgtataatca 102840
tctatttgaa taaaagattg tggtataaat gaagatagca gcaagtcatt ccaagctctc 102900
cattctattt aaacaatgta cagtttaaag ttagatattt taggatagaa attaacattg 102960
tcccacaatg agtaatcatg tccacttcgg ctagtaccaa agcgagatga tcgtgccagt 103020
caccacaata ttttcatatc gaaacaataa tctatcactt tgtcatggag atatcgtcga 103080
catacgtatt attagcactg tatacggtat ctctttcgta tatcagatag atgatatacg 103140
ttcacagact agcgtccatg aaacagaaac tgatacaaat actggcaatc cgtcactttt 103200
aagaggaaat atctccgtcg ggctgattgt atagactctg tcaacgcatt tcttagcctt 103260
ttaagaattc atatcgtttc tatgaatatt agttttgtca ttgcatccag ccacactcta 103320
tcagtacctt tcgatatagt gcattagact tacgggtcat atggaaaaaa taagtatcga 103380
aagtttccca acctatgaca aaagagttgc acggatcgcg cccccaccga caaatacgtc 103440
gataacaatt ttacaaatcg aatacgaaca tgcataccgt acaatcgcta aatatgatcg 103500
tatatagtta ctcagaaata taaccacgaa tgtactccat agacatgatc gtataagaat 103560
gatgtcgcct acacccgagg acgatcgcga tttagtggta gtacgtggac gtctccgaat 103620
gatggataac ggtgccgaac atgatcgaga acggcgatca tacaccgcat ggccccattt 103680
gtgttgtgga tgtaccatcg gaattatctt aactatgttc gtcatcgcga caacgttatt 103740
attagcatca ttgtttgcat tctcgtacat gtctctagag tcgggaacat gccctaagga 103800
atggattgga ttagggtaca gttgcatgcg cgtggctgga aacaatgcta cagaactcga 103860
ggcattagat atgtgtgccc agcataacag taaactcata gattttacta acgcaaaaac 103920
attggttgaa gcaattgtcc cattcggctc cacgaatgct tcctttggaa atatatttag 103980
actacgggac agtagatcaa cctgtatact acccaccatt ggaggtccta tatcggtcga 104040
ttgtccaagg acatgcagcg ttgtatgcca acgcccccga ccattaagta ccacggcttc 104100
tataatcaga gatgctcgta tctatcttcg tttagaacga cgcgattact acgaagttta 104160
cagttccatt ctctcgaacg caattatgaa ataaacacaa aaataaacac tattcttaaa 104220
gcggttcttt atttctttaa taatcgagca tgaaaggtga aagggtatac atgtttggga 104280
caaatcgtta cgctaaagat aaaaacatat atgtttgaac atagtatcaa tcggtagcca 104340
ccctcaacct acgcaatatt cgttccactt tggatgatgg agatttgttt cgtgcggttt 104400
ctctgcatac atataccgat tcgacggcaa ctgtaacagg cggtgtctca gctactgtag 104460
ttgatgattc aacttcggtt ggatcgaggg acgcatcggt cactctcgtt ggagaaccgt 104520
ctgaagctgt cccattattt gtttgactgg aatttggagt gatcgagtca gctggctgtg 104580
gggctggaca taaaactcca cctttcattt ccacgtaatc gttttggagt tcgtccgctg 104640
accacaaagc ggtagcgatt gaagatagtt gtcccgaaga acactcagga acaatcgctt 104700
gttgattatt ctgtaatgta ctgtgtatat gtcccgaaga agacggcatg ctggtagatc 104760
gtgtaaacct cgtatcatgc ctttctccaa tttgagtatg ccttggttta cataaaggtt 104820
caaggacatt attgctcaca atggactttt tgagtaaaga gccgtgaatt accattgact 104880
tggctaatgc aagttcaaac catgctctga tgctaaattc aagttctccc catgccgtgg 104940
ggcgaatgga tgggaaaagt cctcccaaat aatgttcaaa ccgtttttgt tgtcgaattg 105000
ccgatcttaa cataggatta cccaaacccc cctccaacca tcttgcatat ccattaaaag 105060
taatattgat aatatattga cagtgatggt gcaagagaga aaccaacgcg acaatgctaa 105120
ctataggacg caacatttct ccatgtttgg tttcgcgcca ttgacaacat gtccacagag 105180
aactaatatg gataagtgaa gacaaaaggt gttctatgga gcgacagagc aatgcagtgc 105240
tcatccactt atctgacgat aacgaaccca taacctcagt aagatttgaa aatatattat 105300
caatgctgat aggtacgcgg gtgccgaatt tgttagaaac aattcgcgta tctagcaagt 105360
ccattaacca cattgcccac atgtacagtg tcttcacata accaaataac aactccagtc 105420
gagcggaagt atcgagacta ggtgttgtta tttcgtcagg tctcatataa tacacatact 105480
tctgaataaa atttaacgca tcccatattt ccgcccagca tttgacgaac attttgttat 105540
ctttttgaag ccgaaatggt ttttgtgtta agggatttcg ttgtatagct ggataaaata 105600
gcaacgcaac ggtggatctg gcaggttcac gagttcccgg gagatcaaca caaggtatac 105660
gccgccgctt acagacatag cgctgatacg agtctgtgta gtagtctttt accaccgcag 105720
gtgtcaacgc cgcccgtttc aatctgcgtt tcacatttgc gctgtatagg gatatatact 105780
ctcctctaac atctcccaac gcaagatgaa caataacaga ttctggaacc ttattggaaa 105840
gagtttcaca caataccgat tcccttatac ccaatgtcaa cccggatggc aacttctcta 105900
taaggctgtc ctcaagagct cttaatgcag acgcagatac agttaattcg ttgggtaata 105960
tacatgaata ttcttgtggc gaatctcggt caaacagttc caacgactgt tcagaagagc 106020
tgagccgctt cattataacc catatggatg gacacactac agagaaaact gaaatatagt 106080
acaggatgct gcaagagtcc cggttttaaa catgtaccac tcttaaatgc cattattcta 106140
catccggagt aaaagtcccg ccctcttccc tacgtcaatt cgcccgttgt ggctcacggc 106200
gggcggtttc gacggctctt ttctcgaata tcacatcact cgcatcttct atcgcattcc 106260
gtaaaggaac taaattacct agaatgtcat aattaatcgg cgggggtaca agtttcaaag 106320
attctagttc ttcacttttt tcatcttcat aaatcactga tgccatgcca gtaggtggat 106380
cgcctcgtgc aaattcaagt gttaaatact ccatagtatc atcacggtca tttatgtatt 106440
catcaatggt cactggtcta tataaacttt tacagacata cgatagatat tgatacatct 106500
tgaatgtctc tgaccaaaca tccacgtctt ttttgtgata tacagatcca ataaccatct 106560
gcgcgataat gatatttaaa tggccgagca aacgctgtaa gacaacagtt gcagcaatca 106620
cggcagcggt taatttttct cccagcttga cattctgctt ctctagaaat aaatcactgt 106680
ttgattgaaa ctcatatatt aactccgtaa atgcagatct tgtggcaaga tacgcttcta 106740
caagtgttct ccctagaggt gtaccctctg taccatacag agatgactct aacctcccaa 106800
ggcaggcccc ctctgcataa aggagatccg tacttgccat tggtaacttt ttacttctct 106860
cgctggcagt tttcagccat atgtattcac gattgatttt agaactgtaa agtatttgcc 106920
ataaggaagt gtatagaaat tgcacagcta tacatgctgc cacacattcc atcgtaatgc 106980
acgaggataa aattctaagt tcactcttat tcattgacac tctttgggaa gagatccttg 107040
taagtagata tatttctgct tgcaacatag ccacaatggc atatcgtaca attcgtttgt 107100
tctcagaccc taatgcacag cgaagctctg gccaatacgc aagcgatcca taggaagctc 107160
gtgcagccga agccataggg tctcgcattg tatgtatagt actattttcg aatatttgag 107220
catcaccttt ccgaacgtgt ggcattgtgg ataatatttt tacatttcca tatttatgca 107280
ttttattttt atgtatacaa attgctattt ttaaacagga attaagtaaa aataaaactg 107340
cattgctttg attcaactca cgcaatgaca ttacagaact tcttaaggaa tctctgccta 107400
aatggagaat aagagcatgg gcctgtttcg cggtccgttt ccaagcgaga gcattctcag 107460
gcggggggga agtatacatc ttcccattgg cataatctgg ccggctgttg gaataccaat 107520
gtgacacata tttgaaagtt tttgcagaca tatacaataa ttcatcttca cgtatagcct 107580
cggatctggg cacagattct aacattcgca ataatggaat atggttgatg acatctgcgc 107640
taagtgtttt atgctcgaga aaggaggcca aagccggact cgtaccttta ctatcaccag 107700
tggtacgctt ataggttttt agcgactctg ttctagtata taaagcagag ggggttgtat 107760
aaattgaagt ggccctattg cgagaaacta atcggtaatt gtcttctcca aaactatcat 107820
ctatggggga ttcacgagtg ccccgagacg atgtatctga gttttttcgt aaccgttttt 107880
gatcgatatc ggatattgga tgttctgcac ttccactggg agtaatggat gtaaaagaat 107940
ctccgtgacc accggcccta ggtcctcgcc ttcgtgatga cctacggtgg cgccttctaa 108000
cacggcttga tcgtgatgca tgattatatt ctccttctct agacgatcct agactagatt 108060
gggatattct tctatgtcta tcgtgattta tcaaattttg agaacccgtt gcagatcgtc 108120
tggaaccccc acgaaaatgc atatgcatgc tggcattacg atggcgtcgt ctagatgacg 108180
agcgtcttct agacctcgct ctcgatttta atgatgcatt aatcatatca cgagatgcat 108240
cactaccgcg acgacccgaa ggttgcctct cagtgaaagt atctcggaga taacctagaa 108300
aactatgccc attgcttctg ccagatcgtg tacggtcccg cccccgtgaa ttgtcaaatt 108360
gttcctcatt aggaatggtt tttacaaacc cattatcctc gctctcctct agcgtatcgt 108420
atgtatcgtc atcataggca atcgccggtg ctcttgtata cacactcgcc atattatgcg 108480
gacttcgcga tatacgattg cgtgatccac ttctagtcga caagtaattt ctgattgatt 108540
ggttttcccg tcgttgattt tgaccaggat gtccataccg atgcatagaa ggcatttgca 108600
ttcttcggtg gaatgtgcta ccagcatact gttatcaaaa ctacgccgtt ttataatgta 108660
ttgatctaac ggcggaagtg taattgcatc aataatatta catcattgat gggacgtgag 108720
aaacaaagac aaagcgaata cgacaaattc gtttattaaa cgtcacattt acgtataata 108780
tcatttaagt atagtttcgt tctgccaact caccatcata ttaatagaca aatacctcct 108840
tataaagtac tgatagtagt ggcaacagga tcaccagggg aaattgaatt tctgtctgaa 108900
gagtccatca acaatgcttc gacagtagtt ccatagtttg gcggtgattc tagcttttga 108960
acatgtacat gttccttatg cacatgcaat tgcgggttag gggggtgtga tagagaatat 109020
acttccaact ttgatctaat acactgcaat aaatatactg atgcccgagg agcatcacct 109080
gaaaacggtg ggggcgagat caacggcatg tcaggctctt ctactaattt acatcgtatt 109140
agaggaagac cgaactcgga acgtatataa ttctgagccc ggagttcagg agcagtcaaa 109200
acacgccctt cgacaataac tacgccatgg ttaaaaatta caggttgaaa taaacaatga 109260
aagtgtcttt cttgtaacca ttcgcatttc aaatatacaa atatattttg tcgtcccatt 109320
tgagatgctt cgagtcgctg tgatacatcc cgcgtggtag aaaggtataa gtgcacatat 109380
aagagcttcg caaaccttgc cgcttctcga taataccttt cggcgatgta ttgtcgtgct 109440
ttactacacg caccaatatt tttatcttcg actcgagcgt cccgaagatc tttaatcgcc 109500
gactgtctaa tatactctgc cagagcacga cagtatccat aaaacatagt agcatatgat 109560
ttctcccttg cttctaattc tcccaaatag aagttttgta tgtcgtctac ataagaaggt 109620
aaatcggcct ttgttgtggg aggcatgggc agggccatct ctccatgttc atttaaattt 109680
aaagccgtat acgtccatgt attcttcgac aactcttcca atacttccga aggagataca 109740
gataaaattt ttgcatgttc atataagtgt ttattatgag ggaaacatga gaatagatct 109800
acatttattt tttccagacg tgctaatata gacgggcctt cgacaaaatc caactcatgc 109860
aacagtctag tgtagagaga attgggagga gctggagatg gggatggaag tgacatttta 109920
gtaacagacg gagcaaccag aggcgatgga atagattggg ttctgacttc aatttcagag 109980
agaagcgttt catcaaattc ttcaattgtt cgtaggatat caagatccgg ggacttatcc 110040
atagtattcg catacgcctc aatttcagcg aataattgga taggactgta gtaatcgttt 110100
tcaaaactca tatttgcctc cattcacact atacaataat gagtagataa gatatatatg 110160
tactagtttt taattcggat gtctataaaa gacgacttac ttgcagtagt agggctgttc 110220
ctatgttaca ttattcgcta tcactgccac gatatccgcg ggcggatgaa tgatggcgac 110280
gcgaagttgc gggagtgcga gggttatgtg tacgatgaga tcccggatct ggcgatttga 110340
tttcaatttc accgccgcgt cttgtacgtt cagatttggt tgtacgttca gatttggact 110400
ttacgttctc gttcccctgg gataatccag actcttccaa tagtttgcgg gcacaggttt 110460
cggcttcccc catcaaattt ggaccctctt gaatggtaat tttaatgaca gctctggaaa 110520
gaaatgcatc taattcttca tttgttcgcg gaggatcttg acgccaaagg gcgagcgcgc 110580
cttggtatgc gtgatattga gccacagttg cgaccgctcc gcaaaacata cgctgattaa 110640
atgccactgt atttgatctc caagtgctag atgctgatga aggagccgta ctgaaagcga 110700
atttattact ttgtacagct ctgaccccgg gcttggcacg gggtttgttt gtaaagccac 110760
cccgggtggt agacgaaacg tcttccgata cggctttcgc cgatttatat ttttgtgttg 110820
gatggtcggt aaatggtcca tgttttgaca aatcatcctg gtttaaattt cgctgagtac 110880
gtgttgatgg tctgcgagca ggaatcgaga cgtcatcata tgcagaggga tatccaaggg 110940
aacgacgccg ttccgatttc cgcctttcag aatcccccat gataactaag atataatatt 111000
aaacagtaag atatgaacaa gtgcaccttc tattgtaccg tgtggcgtct ccaacatatg 111060
aatattggtt caaagtcaac aaatctctta tgaagagata agagatttgt ccacgcccac 111120
ataatttacc actcctcttt aaacatatct gcggtgaata gtcgaaagca tgcgtgatac 111180
gaacccgcta agagggcgga gattaccgcc accagaccca gataaaacag cacagaaaac 111240
ccagatgaaa aagctattga cacgcctact gcagaacacg tagactccca aaaatctccc 111300
atacttgtga ttgaacttcc ccaatcgaca aacgtcgctt gcgaagtggc aatcaaaata 111360
gcaacgccga taactaaact acagactgca ttatggatgt ccacgagtcc catcctcgtc 111420
gagatcgtga tttggagaat ataacgttgg gagcactaac agttccctgg cgtctgcaat 111480
tccgtgtcga tgaagcgtta tatgcagtaa acccaaacgg ttggacctgt tatatagaag 111540
agcgtgatca gcgttgtctt cgcgttacca acaattgtgt gatctcgtta ctgaaatcgg 111600
atttaaagcg cagatatcaa acgtgtacat tgaatatcgg aatacgagtt gccgttcctc 111660
agaattacgt ggtcattttg gcaaagttaa cggatccaga cccaacttct cgaggtatac 111720
ccttcattca agtcgccaat ggattgatag attcaggata taggggatct atccgagcag 111780
tattgttttt tgaaaaatca tgtatcattc caaaaaatgg gctggctatt cgtttatcac 111840
tagtaaagct ggcatctccc aatttgaaca cacgagtgct attcaatctg tctgacatta 111900
caccccacct agaatgtggt ccagactttt caacttcgat agaaactgct gtcagattag 111960
gaagcgggga gaccaaacca ctgttgccgc caagtggagg tgggatatgg gcaggaactg 112020
gatgccgagc gctcgcatgc ttatacaacg atcgggtatg caaagcgtcg cattatacat 112080
catcggataa aaatatcgca tttgtagtac ggtataatga ttccacaagt gtgttaggac 112140
ttaaagattt tccgactgcc gaagacgaaa cgtttgtacg tttctataca tctggtcaat 112200
ttgcaactct cattcctttc tttgagacat ttactcctaa acgaacagag gatgctgcct 112260
acgacatagc cgccccaggt gatattcgat tgggggcatt atcgtctaca actatcatga 112320
tacagcagcg atatgtatgt atggacgact ctgtaatacc ttgcatattt ggacgctcat 112380
ccatgaatct acgaggcttg attataatcc ccagtagatg gcttccaaat tcctggctaa 112440
ctattactat atgcaatttg accgaaatga ccgttatgat aagatgtgga gaccgtatag 112500
ctcaattgtt gcttgtagat cacgaatcgg ccacgctaat tccgcccaca aatgatacta 112560
ctggaatgtt tcccacagta ggtaaatgtc gccgccctgg cgcatcggtc ggggagccga 112620
aatggaggga aaccttagaa tttgatacag aagcttacag cagcgagaga cagttttccg 112680
ggtttggatc caccggtata taattgtatg aaaacgccat tcatgtacaa agaattatta 112740
ctttacaaca ataaacgaaa catactcgag agtatttgct tctttcttta ttataattcg 112800
gtaatgagat tattttccct agaaaactta actggtgggc aattatcctt tggggttaca 112860
gccggagtag aaataattgt acgttccctt tttgactgtg agagtaaggg cgaagatatt 112920
aggcgatcga tggttgtatt ataaccgggt tccatattca cagcatcgtc cttattgtca 112980
ttcatatgtg acaatactgc acaatttttc atcccggttg actcgtccat tgatgcgggc 113040
gatctctcat tatgtggatg cgttaagccc aacgctctct ccaccagtgc tatatcgctc 113100
atcgcagttt cggtagcagc cgttaattgt attgcatgtt ctacaaatgc atccgttcgc 113160
cctgtgccga tagacatata catatgcaag agtgcggcag cacatgtatc tgcaactcgc 113220
tgtgcattct cccgatgcgt ttcaactacc gcatccaatc caggatttcc ccgtcctgga 113280
acatgtttag atagacattc taaattgcga aggcatgcac tgtacgttct agccaatgat 113340
tggccacgaa ccagtttccg taccccgtcc gcagataata aagccatttc taaagtgatg 113400
ggcgtgggaa gaagaatgtt aacggcatgg accgcctccc tgagacgatg catagcttta 113460
tcagtagaag atgatgcaga caattgttta tattctgctt tgagtcttct gtagtcgtat 113520
gttcttgagc tggtttgcat tatggcgaga ttttcgtcta tatccgatac gctcgaaagt 113580
gatgactcgg gaattaaggt cttatttgcc gtagatggtt gtgccgtgtc gttttccctg 113640
gcccttctta caggtcagat accctctact aactccgttt atgttatcgg ctattgggat 113700
ccaagcgacc gattttcaag catacccttt ctcgacgggg atcctaatac taatgagaga 113760
atatctacca ccgtttgtaa tttagaggat gttcccagcc ctctaagagt agaattttgt 113820
cttctgaacc aaatgacatc aggtatgggc ggtgctgatt taaaactgag aacacgtgca 113880
atattcgtat gccgatttac atcatggtcc gaaatgaacg ctatcgcaaa ttcaataatt 113940
tatggaacgc caattcaagc cggtgtttta caagcaacaa tatctgaaac tgaaacgttc 114000
atgttacatg atgaattcaa ccttgctctt cacgtctttc tcaatgggtt atctctgaag 114060
ggtcgtaaca aaaaagatgt ttgtatgtca ttgaatcaca attatatatc gagcgtatct 114120
gagaatttcc caaggggtaa acgaggtctg actggactct atttacaaca cgaacaaaag 114180
gtcacagcag catatcggcg tatatatggt ggatctacta caactgcttt ttggtacgtg 114240
tccaaattcg gaccagatga aaaaagtctt gttttggccc tacgttatta ccttttgcag 114300
gcacaggaag aagttactgg tattgcaaca ggctatgatc tgcaagccat aaaagatata 114360
tgcaaaacat acgcagtgtc ggtaaatccc aatcccacgg gatttttggc tgccgattta 114420
acgtcattta gtagattatc acgtttttgt tgtttaagtt actattccaa aggctctgtg 114480
gccatagcat ttccatcata tgtggaacgc aggattatgg ccgatatcgc agaagtggat 114540
gcattgagag aatatataga aagagacaga cccagtttga agatttcgga tttggaattc 114600
gttaaatata tatatttagc ttattttgaa tgttataacc gcgaacagtt aaaacgacat 114660
ttgaaagatg tgacagtaag tttgcccgat gaagacattt acaagaagtc ttcactaggc 114720
aagtgtgcag tagaaaattt ttttacacat gtgagatcta gattgaacgt gaatgaccac 114780
atagcccata atgtattgcc cgaacaagta gaaatgggaa ataagctagt ccgaaagttt 114840
ggacgtgcca gaatgtatct gtcaactacg atgactaacg agtcgcactt cactggaata 114900
tgtgaatgtg catctgtgat tttaaagcga ctggacactc tagaaatgaa attgcaaaag 114960
tatggttggc cgtctgatcg tgtggatggt tccaatctaa tggccgataa tcagaacagc 115020
tctactttaa taccgtatga taaatctagg tcttctggaa tgatactcga gtgttcgaac 115080
actcattctc gaggggggcc gatgatagtt aaaaggttat tagctttagt atctgccgat 115140
tctcgcgcag ggggaatcgg cccagctaac atgctcatgg ggatcgactc tgcaatagat 115200
ggaccccttc cagtttaccg tgtgggcatg tcaaagggca gacaggcttt tacggtgctt 115260
atgaccgaat gttgggaaag gaccattcca tctccgggaa gtgcgaaagc gcatttgatc 115320
aagcttaaca actcttacgg tacttcgaca gaagacttga tttcacgaga cttattccta 115380
acttctgaaa tcgaacagct tatcggaagc acagtagaat tgccggagat tacatgtggc 115440
tctgccgatg aacagcaata tataaaccgc aatgaagtct ttaatgggaa tcttgcgata 115500
ggaaatatag ttttagatgt ggatatacat ttaagaaacc ccatacctct tagacttatg 115560
catgcagcga tacgaggttt tagaagtggt atactcagag ctttggcctt attgctacca 115620
aaggcaaata tcgaccatgg ctcatacccg tgttactttt ataagagttc gtgcaagaaa 115680
tctagagtaa tggggggagc gccttggatg ctccatgatg cagaacttgc cccagattat 115740
tcgatgtttg aaaatgcgga gtttgattta gaaatgggca tagatgaccc tttactcata 115800
gaccaaatag atgaatctct tactagatgg agctcagaat catcaaggag tgtcgatttg 115860
gatccagata agccatgcgg ttgccatgat aaaatcggat tgagggtttg cattccagta 115920
ccctctccat atttacttgt gggtagcaag acattggccg gattgtctcg aatcattcaa 115980
caagccgtcc tcttagagcg caattttgta gaaactatag ggccatatct gaaaaattat 116040
gagataattg atagtggcgt atatggtcat gggcgtagct tacgtctgcc gttttttggc 116100
aaaattgatg aaaacggtat cgtgtctaga agacttgtac cgtttttcgt gataccagat 116160
gattgtgctg acatggagaa gtttattgtg gcccatttcg aacctaaaaa cttccatttt 116220
cacagctcta tcccgctaga aaaggccgcc ataattctga aagatatagg tggcgaatat 116280
gcaagtttct tcgaaagaaa aattacagta aatagagata tatttttcgg gactcgatta 116340
tctttatcaa tagctctcag ggaaaggggg gtagatataa atgattgtgc tgccattaca 116400
acatttgtaa cagatcacat tttagatgat attataacat acgtatatga gcatatacca 116460
gatcacgcaa tcgaatatca aaatctttct gtctcgtgtt gtgttgtcaa atcggattgg 116520
atcctgctgc agctaatccc caataaaaca ataggatatc gtcacgggtt tacatgtgtg 116580
agatttaagc atgcaagagc aaggcgagcg agtgcacgtt cttatttggc tctgaacgtc 116640
gatgcgcatg gtaggttgtg cgtatgtgta attcaacagt gttttgcggc caagtgcgga 116700
aataataaac ttcgcacact tttcacggta gatattgact cgaaatgtcg attagaacat 116760
caatagctct catcggaatt ttatttgcta tatcgatata tactgtttta ttggtagttt 116820
atgtatcgac gctttcccaa aatggatctg gatgtatcta tgctaccttg gtggacagta 116880
gcctctatga cgccaaaaac ttcacgtggg aacaatataa ttctaccttg atatatacag 116940
cactggggaa taaattgcct ctggatggtg gatttgacga tttcagcgac gtatgtcgta 117000
catatctagt caacttaacg tctatttccg gactcgcttc acacgtttct accaagccca 117060
agattcgatc ggtagtagga acccgcaatt gtgtgacgta tctttggagg atacatatac 117120
aatctttgtc ctcctctctg gggttgtata caatatttta tgtcattcgt gaatggagac 117180
gcatgtttgg tgtagtaaga tttgaggatg atgctatatc gacagcaagg tataccaaaa 117240
attatgccgc ccgagtgata tctagtgttt tactcaaaac aacctacact aaaatgtcta 117300
gatttatgtg cgagataatg atctataaaa atgctttgag taggactttt aaagatgatc 117360
ccatatcatt tttgtttcat caccctatcg cagcagttct tattattact gagggtttag 117420
tgcgattagg ggctcagtgt ctttgtctag cgacactatc gatgtatttt gtaccatgtg 117480
aaaaagttct ctcgaaatgg tttttatcca taacaggcat ttttatagga attataatct 117540
gtatagaatt gagcttgtta ttggctcccg gcccagttga tggagctgcc atgttgggag 117600
aaacaaagca agttaagaaa gatgaatgtg ccttggaaac ttccccatct ggcgtacatg 117660
ttttttgctc caattgttgc gcctctttaa tatctaacat attaatcaaa gtgctgtata 117720
tattgttcat gataatattg attgtaacta tcgtaagata tgaacgaacg cttcaaattg 117780
cattgtttgg gcgtgcctat ttgccttagt atacttaact catctcttag atgatttgca 117840
ttgcgcggat atgacataac ctacggggtt atataggttg atatagagct ataggagatt 117900
gtctcctcaa gtgtacctaa tggactatta tctatatcaa gattaaacaa aaaaatgtct 117960
gtagatgcat tctctcgcga gtccgatgac atgatgagtt tgttggacta tgattttata 118020
gaaggatcct cctccgatga aaatgccgaa gtgactgaaa tggaaacatc tgcaaaaacg 118080
gctaatgaca agaatgaagt tttattcgcg ccaccgtgta cgcaggaact tttgaccgaa 118140
cgaccatctc ctgattccaa aaattcgcaa ggcgacgatg actcaaattc aatatatggc 118200
aacgtgattc gtgatgctca acactcagca agtcgatatg ctacaaggtg tcttgacaat 118260
gcaataccac ggaaacgtct acgcttagct aatttgacag tagattctgc atgcatttcc 118320
caaactaaac ggccgcacgg tacaggcaat cgcaaacaat atcacagacg taattttccg 118380
atgtcaccga cttcacaaga aaaaattcat ctacgattgc acaaccgact tggatctcgg 118440
agcgaaaaac agcagcgcag tctaaattac gaccgacgtc tgcaagaagg gcatcaccga 118500
agaagattct acagtgagag acgtatttat gatcaaaatc atagtcacca tcgtacacac 118560
gatatacggg taccattgga aaaatataga gtttccagac aacatgatct ccctgtccat 118620
gaggaactaa acgaaatact tcaaagagag aaacaccgtc tggcctctat ttcaaatgag 118680
tgtgattttc gcgtttcgag caaaaatcga tgggctgccg tattaacatt ttcaagcaac 118740
gcggagagta ctttatgtgg tcctcagata acatgggagt atttattgca tgcgggtcca 118800
gagctacgaa acacgttcga aatcagacct agaatatcgc tacaagcaag tgcagcacga 118860
gaagccgtgt tgcgaggtga aagtttcatt gccgcattag ggagtgctga agaaactctg 118920
tcgtggttaa aactacatgc tgttttaaag ttacgcctag taaatcatga cccgattttt 118980
aagaccgctg gtgcggtttt agataacctc aggctgaagc tcgcaccaat aatgatgtgt 119040
aaatatggaa cagagaaacg ctccatgggg gatatgttaa gaagatctgc tcctgaagat 119100
ataaacgatt ccttaactct gtgcttaatt ttgttatcgc gcattcgtcg tgtgatgcat 119160
cgcacatcgg gcagcaaata cagttatatg atagacccta gaggatgtat gatagactat 119220
gtacctggag aatgtatgac aaatatacta cgttatgtag atgcgcatac gaggagatgt 119280
tctgatcccg catgtaactt gtatatcagc tgcacactca tgcctattta tatccatggc 119340
aggtattttt actgcaatac tctgtttggt atgtaaatag ttatctaaaa gacatcctat 119400
atttagtatt ctacacaatt tcttctgacg atattactaa ctcctctaat aaagttaaat 119460
aaataaacgt ctcagatatg tcttgttaaa gtgtggtttt attatctata tatcaccgac 119520
tttagatacg gaatatgaaa atgatggccc tgaaattgca cgaacagctg tggtgaagat 119580
tccgtcaaat ttacatttga aatttaagta tataaattca ggtgatccta taacatcgtt 119640
aaacaagctc tcgagtagtt taatgaacgc taaacattga agtccaccag ggcgatcaca 119700
aaggcagttg actaacatgc catgcgctcc aggattgtcg cgaactgccg actcgcataa 119760
acaaataatt tttctcggat ctctcatttc cagaaatcta cgcgggtcca tcagcaatgc 119820
cggttttatt cctggaacac agttagacgt aaactgctcg aaaactgttt taagcacaac 119880
cgggatgtct gcaaaagccg atgatgcttc cttataacag cgctcagtta gaaaccataa 119940
cagttctttt ggtagtatat ttcttcctag aaaccatggc gttcccattg ctaagaacca 120000
agcatgtgtt ttcactgtat cttgtccaaa gagccctcta ttcggagatg tatattggag 120060
atcggatgtc cagagtactg ctttatctcg catagatgag gtcgcagtta caattctccc 120120
tttccagcca cccgtcaaca tgatgtttat tggactacca acattggtaa tgagtactgg 120180
tctggcgact attccatatg cattagtcat tgaaatttct cgtggaatca gccaaactgg 120240
agaatctgca caatctttat tattcgatgt ggaatgacca tgatcgcttt gttggtctgt 120300
accgttagca gacatattca gagtaatgtc acgaagactt aagggtggct ttcatttcaa 120360
acctggagaa cttgtagggt tgtatagtcg acaggatgta ggtggagaca tgacgtctac 120420
aaagagacat cctataaggc cattcctgca gaaacttata ggtttatacc agagacgact 120480
caatggcagc aggggcgatg tcatcgtcaa cattggctca aataccgaat gtataccaag 120540
ttattgatcc cttagcgatt gatacatcgt cgacatctac aaaacgatta ctggatgaac 120600
ctgtaccaca cataggatcc attacatccc gttcatatct gctgagagta aagtgtagtt 120660
ctcctgaaga ttgtcacgcg tttttctttg gtctggcaac ggaagcatct gggaatatgt 120720
ctcagcatgg cgccgaatat attgcacgca gcaggaacga gaaactatac acaggacgaa 120780
gtgcggacga attatgccat acaccatttt cccacgctac tattctggat tcgttagatg 120840
acaattatac tctaaatatt gaaggactgt gttatcactg ccattgtgaa aacaagtttt 120900
cacacgagtg ttggaaagca gtttttattg cgggagaaaa gatagcgtta ctttgcaagg 120960
atctgcaaat gtactgtcat taaataaaac cgtacaccag aatttactgt gcatgcattt 121020
tgtttttaat ttgagtctag catttacatt agctgaatta ttaaacttac tcgataacag 121080
ttccgtatta tatgtcaatt ttatgataac aatctgatac atatgttaat tggaatatac 121140
actgctatag tttacgggca ttcgaaaata atcctaacac atataacggt aaatctttca 121200
tttctaatac cgtccggata aattttacga gtttgtagat gtctttgcat gttagaaatt 121260
catttcaatg agattctttc gtccgttgaa gtgagaggaa aaaaatagat catgcttgtc 121320
caattcagac tcgctggtca atctactgtt gttggtccaa accttacttt cgatgagcca 121380
tgacttaata ttctatcatt tggattgata gtactcaaaa ctcctgacgc gctccattca 121440
tgttcgtact gtgtgcaact ggctgtgttg gcacttcgat cgacagatat gccacgtcgg 121500
cgccccaaag atgaatcgtg atacttatga tagcgtttag gtggggaatt aagtttataa 121560
cccccaaatg tacccattgt caccattaaa tctctctgac ttatcccggt tttacatata 121620
aattcgtgaa gattttggct cataaaatgt atgcagcttg cattttccac tccatatatg 121680
tttccgtcct gtcccttgag aataacaaat tcacgtgtta gtccatccgt gcgtgctcgg 121740
ccaaccctat acatttgtat ggatgttctc gatccggccg ttgtaaattt catagtcgat 121800
gttccagcat ttgcaaaaat caataaatcg cctcctcctg gtaaatccat attgcgtccg 121860
cgcagtgatt ctattaatgt tttgtccgtg cgttcaatgg ggttggaaaa aataatgccc 121920
attttttaaa ttaaaaacaa caggtacgat ataccaggta atgaagtaaa ctgtagacat 121980
gtaaaatggt tgtactgaaa ttcgtgagta atatataaaa ccataatgca atagatcatt 122040
cagtaaaacg cccacgagtc tgtataagtg agtcaaccta acatgtgtcc atatctacat 122100
gtaaagagct ttctacatat ttttgagctt cggtcaatgc acgtgttggt atagccgcga 122160
tccggctctc cctctctggg gtcggaacac aatgcatatg aaataatatg ccatatccaa 122220
aaaagttatt agtcatgcaa gcatctgtca aatagcaatc acataatgga atcaaatgcc 122280
tcaaagctgc ataatgaggg gaaccttctc ctcattgaaa ccatttatgg aacctacgag 122340
tataggttgc agaaattacc gtcaaaaaaa gtattaataa tgtagcgatc gcacttccat 122400
catgtcgaat gataaaacgc aagtcaactt ctgcgcaact ttcagaattg ttaacattat 122460
gtatcgggga tagggaatcg tatgaagggg gtgggtcaac tgcatcatcg tatgtgggca 122520
acagtgcgga attattgtat ctggtaacag attctaattg taaatggata tattctgtgt 122580
gtctatgtct acatgtaaag agctttctgc atatttttga gcttcggtca atgcacgtgt 122640
tagtatagcc acgatccggc tctccctctc tggggtcgga acacaatgca tatgaaataa 122700
tatgccacag ccaaaaaagt tattagtcat gcaagcatct gtcaaatagc aatcacataa 122760
tggaatcaaa tgcctcaaag ctgcataatg aggggaacct tctccccatt gaaaccattt 122820
atggaaccta cgagtatatt ctgccaacca tcgtttggtt tctgcagtta tcacccgaaa 122880
tcctttaaat ggaaagaata agcccaagta ccagtcatta ttttcaggct ttagggggca 122940
ccgtgtcgtt aaatgggtaa caaattcgat ctgagaaggt atgtatgtca aatattcaga 123000
gcttctaaca atacactctt cccagtgaga tggcaataca ttataattct cacatctaac 123060
taccttgggt gtcgtacaag ccgtaatatg tgttgttcgt tgtagaatac acctatacgg 123120
acttgttcca atatcaggaa tcgattcgat ggttgagagc ctacgtattc ctgatactgc 123180
taagagatca cacaaaacaa gtaacttatt aattccatca atcaaagttg tcatatctat 123240
tgcagcaccc ccaaaagaaa ataatgtttc tgtacatgtt ctagcaccgt tttcaacatt 123300
gctcgttacg accgaaagac taaaaataaa agccaattcc ggtttagact tctcaagtgg 123360
gacgcttatg cggcgcactg tactttccag ctctttcctg aagttagacc tcccacattt 123420
tccagctctg ctccaatctg ctgaaaaaaa tttacgtaca attggggtta tagacgtacc 123480
aatgaacacc ttaaaacata aatcctgtgg agggtatact tcagtattat cgatatctag 123540
atcttctaac ttttgtttca tcgatagtag aacacgttca caatctctat tcgcgggcgg 123600
gttgcacaat cttctcaaaa aaggtttgat caatgcaact gcaccgcatc tcgacacatg 123660
taacgggggc atagttgaac gtgcaacagg tctttctgta agcaaatcta gacatatacg 123720
ccgggagctg cgatactgta tattatgttc ggctgtatac gtagaatgac tacgatggag 123780
ccaatcatcc catgtgccag taaagtacat tataggtgga actttttttc tttgcctcac 123840
cttagaagtg atggtggtac tatccccact gatgtgtaaa ttgagggttt ctttccaggg 123900
ttttagtttt tcggatatta acatatcgtt tgcccgtcga caatactctt caactaccca 123960
ttttaaatcg tctaagtaca cttcagataa ttccttgaca tagctttcat ctgcatcaca 124020
atcacaacca ttcggaaaat aattgccctg attattatgt gtagctgcgg aaccatcaag 124080
ctccatttta tgatataagc gagatacagt atccctggta taacgataac agggggcaat 124140
atccttacta gggtataaca tgcattctgg agaaacggac gttatatatg tgtttggatc 124200
tctgggttct aaattttcac tcgctcgtat ccagccatat ttatcctcta cgggttggag 124260
tatatcggaa tgtttcggtg ggggaggatc ctctatcaga aaatcaattt tcgagatttc 124320
tgatgttcta gtatttgagc tatgtggttt atccaccgta gttgccgaat catacattaa 124380
catctcagct agcatgacgt caatattttc aaatgcccct gcatacaccg cacccattcc 124440
catttgtgta caagtatttg tgtcgacatc gagctcccaa aacgttgtta ggtaatctcc 124500
atagagagca aaatctgcat ctgtggtatt tcgtacaaag ttgaccacat gactccaccg 124560
ggtagatccc aggcgtatat tgagccatgc tattgagttt ctcaattcat cataatcatt 124620
tccgtgaaat gttttatgat cccattccag taaaattatt gtatacaatt tagacttgta 124680
taaagagcga agatatgcca aatctgtgga agggtttgta gactcaggca ggggtgtcac 124740
tgtaacagcc tcgagatttc taccaaagtg agtcctacgt tcgaatcgta tcaaacctgg 124800
catacccgca gcatcggtaa cctgaacaca tcgtaggact gtgacttctg ttcttatcct 124860
tcccaataat gaccatggag gcccacaatt tatgttatat aaagcttgga ttatggtaga 124920
tctggttggc gtacattgaa attctggaaa ccattctgca gacggtttag gtgggtttaa 124980
attctgaatt tgcccgctta cttgcatcca ttcatacatt gagcaaatta gagtatgagg 125040
atcgggaaca tcgtcaaaat gggcaaatag agctattgta ctacgttccg ccggtgcgga 125100
gcctatagac ataacatatc tcggatttga tggcaatctt ttgagttggt ccaggaacaa 125160
cactgcaccc gatgagaata cagtcctttc aggatcgttg tcttggttgg ggtgcctatt 125220
acaatccacc ttttttctcc ttatagaaga agcgaagcaa gacatcctgg cgcagctctc 125280
gccaacagtc gtctgaaaca agcaatatat tcttaagtta taggtacgtc aaaccacatc 125340
caggtatatc ccctctcttt ataaaccgta caatcatact catatattgt aggtatcaca 125400
agtgagaaag gagcaaatga caacatccga gtggtacgtg catatttatt gtatcacata 125460
cgtcaattat gtttctgtga taatagttac aagggttgca gaaattaccg tcaaaaaaag 125520
tattaataat gtagcgatcg cacatccatc atgtcgaatg ataaaacgca agtcaacttc 125580
tgcgcaactt tcagaattgt tgacattatg tatcggggat agggaatcgt atgaaggggg 125640
tgggttaatt gtatcatcgt atgtgggcaa cagtgcggaa ttattgtatc tggtaaccga 125700
ttctaattgt aaatgaatat attctgattg ttcatcaata tctgaaagca caggttcttc 125760
ctcgattggt ggggagatag tctcgggtat agaaacggca tctgcatcca aatcgagact 125820
ttcgtgctgc agctgtccat tttccatttt ttggtctttg tctgcaccaa tattcgtaaa 125880
ggtgagaatt cgcttaatct ccgcctccaa cgtcgggtac ggctacactg tattaaattt 125940
aatttgattc agattttgtt tctccagatt ccacctcccc agaatccact cccccaacga 126000
caatgcctgc acagaaagcc attaacaaac atacagtatc ccataatggt gtttttacgt 126060
ctgccgttct accgactaac ataccagcga aaaatgacat gcacgatcct agtaataatg 126120
attttgcaga acagatcaat gtaaccagca tataagaacg cattgttgca ttctctgact 126180
ccacggatag aatagtacgg ggtcgttgta caagaacccg ttttttattc aaatgctccc 126240
ccaatatatt tgggttttgt ctttcggcca gcattaatgc gcgaacggaa tgtacaacag 126300
cttgctctgc ttcgacaagc aagtccgcat atgttcctcc ttcgcactgc tgggcaagct 126360
cccccatctg cttcatacca tctccctctt ctttccccgt agagctaccc ctttcggttt 126420
gtttcgcata ccgactttcg tcaagatgtt cattccctga cctccggggc tcaggcggta 126480
gctcccccca ctgtgacagc cactctccct ctccggttag ctcctggcat tctatcgcct 126540
tcccatcacc ctttattgga atagccccct tccccgtgac tccagagtga gggggcggag 126600
aactgaatct ccaccggtcc ctctggaccc gatccaaagc gctcatctcg gcgtccccgc 126660
atttctcgcc gtcctcggcg cattccgctt ctgttttccc atgccctgcc tcgtcggcga 126720
cccctgcgcg gccctccgcc ccttttccac cctggggagc gggggcgacc caagacgccg 126780
tcagcccttc gtgttctgct tcgaattcca tcaccccctg ccgatcttgc acgcggggac 126840
gagcaaagcg tgcggtgcgg gcagaaagac aaggatggct gtgggttgaa gatgaaagac 126900
aaatcgcggt tgtgggtcat gagtggaggg agggtgccat ctgtgatgcc gagagggtca 126960
aactatgtta taaagaaaaa cgatgggtgg gaaatataat aaagcaaccg aaatggtaca 127020
taaaaactaa aaatacctac acggttacac caccgatcag gcgaagaagt tccaaacgat 127080
taacaaccgg gacgagacgt tgccgttcga tccaggtctc gcttttttgt gatctcttat 127140
cctataccgc cgcctcccgt ccgacgagag caagtcgcac cgccactcga ggccacaaga 127200
aattacgatt cttatacggg tgggcgtacc gcctactcga actatcacgt gatgtgtatg 127260
caaatgagca gtgcgaacgc gtcagcgttc gcactgcgaa ccaataatat attatattat 127320
attatattat tggactctgg tgcgaacgcc gaggtgagcc aatcggatat ggcgatatgt 127380
tatcacgtga catgtaccgc cccaaattcg cacttgagtg ttgggggtac atgtgggggc 127440
ggctcggctc ttgtgtataa aagagcggcg gttgcgaggt tccttctctc ttcgcgatgc 127500
tctctcagaa tggcacggcc gatccccgat atatttcctg taaggaacgc tacgctaggc 127560
gacgaacgag ctgaatttct cccttcatca aataagtaat aaaattacta gcattcgata 127620
agcaaataaa aaaaaggatc ccaattaata gaacggcgat tttttattta cggcgatatt 127680
tggtgatgaa gcggttcgtc ggtcagtccc gacgatccgg gaccgcagac caccgtcaac 127740
atcgacccgg gatgagcctg ctgggcagac ccatgggtgt cgtttctgta tggtctcatt 127800
tgctcatgtt atggtctttt atcggaggaa tgagcgacgc ggctgggtcg tgcaatgtag 127860
aaaggatggg ctgatataat ccgatatttt ttttttgttg gggggacagt tccacaatat 127920
aggaccgcga tcattaaaat gggaaggttt attctgcgaa tgttgattac atggaaaaat 127980
atgtatgtgt gggagaaagt atgtcgattt taaatgtagt tggagttcgg tattacttcc 128040
tatatagatt gagacgttaa tattttaaaa aaaatgcgat gaaagtgcta tggaggaata 128100
agggggtggt gctcggcgag catgttctgt aactgccctt gctagggttc ttcacacgag 128160
cctcgcctta ttaaatgtga gttcggcaat gcttacgatc tgccgaaaca agtttttatg 128220
tctacttcca caagggggtg gtgctcggcg agcatgttct gtaactgccc ttgctagggt 128280
tcttcacacg agcctcgcct tattaaatgt gagttcggca atgcttacga tctgccgaaa 128340
caagttttta tgtctacttc cacattcaag cgctttctca tagggattct cattaaagac 128400
aagttcggta acgctttcga ttagaaactg ttttaggtgc ccttatatta caccttacga 128460
ggatctcctt aaattcgagt ccagtaattc ctttgagtga cgggaagcct tacgagttgc 128520
cccccccccc caaaaaaaac aaaaaaaact gtcttataag gagcatggct aaatgcgact 128580
tcggtagtgc tttcgaccta gcaatctctt tttttttttt gatttaatct cccttgttaa 128640
gatatgatgc aataaataca cgacatgaaa ctttcattta ttgacgaatt gcaccattta 128700
aactatttgg gcgttgttgc acgattatgg ttatacttta cctgcttttg ctgcgtagct 128760
gttttgtgac gtcaggtttg caactcctcc atcaacgtcc ccgcgcttcc gtctttgtac 128820
atgataaata ctacggcaga aagaaggtta tactttacct gcttttgctg cgtagctgtt 128880
ttgtgacgtc aggtttgcaa ctcctccatc aacgtccccg cgcttccgtc tttgtacatg 128940
ataaatacta cggcagaaag aaacccttct cagttgtcga ttgacacggc tctgggtggg 129000
aacggtatgc catgacagat ttgatttagt atggaatgac cgagtgtgta ttgctgatat 129060
aatagttttg agactgcagg tgtaggaggc ctgtattgga tatgtctgta caagagctgt 129120
tgacacctct gatataatca agttatagat atgtaacatg ttgattgaat gtgtactaat 129180
gaggtgggat taatttgaga tgtatcatca ggctatagat atgtaacatg ttgattgaat 129240
gtgtactaat gaggtgagat taatgtacga cgtaacaacg ataatattgc ttcaaaggat 129300
ttagctgagg gggcaaagtc tgaaaatgtt ggcacaatga accttaacaa ctgagaataa 129360
atcgtatcgt gatcatactc aggtgtatat gttttttttt atgaggtaat gtcactgtta 129420
gactcagaag aggggattat ctatagtttt tatactacgg tagtatggaa ggctatatga 129480
gtttttctgc tgagatagga agcgggggaa ggggtatgtt tcatgagaca gtagatttgt 129540
ctcatcatcg acaactcctc cctcgtggct tcgccccatg tttgcagaga ctcctgcaat 129600
ctatataatc ccaagttcat tctgggactt tccctacacc cgattttggt tggggtctct 129660
acctgactta gtaagtgtgt cgggaagctt gaatttcact ctcccctcaa aaaaaaaatg 129720
aggtttggtt acccaggtag tgccccccca gaaagaataa tcactgcttc gaacggagct 129780
cgattcatca tccgggatta tgctttgggg gatcccaatt ttcgcagagg taaatatcca 129840
tgcgtgatct atttgtggtg gcaatgtgga cttttctatg cctcaggaag aacatatcta 129900
ctttgttgga ttttgtgagt gagaattaag aacgtgtata tgaagcagga ctgaaaaaaa 129960
aaaactatta agttctacta acaaagtgtg ccggtgtacc taccatccgt gttgattaca 130020
gctgtgatat cgttgcagac cccgggtgca ttgactgcgg acccactttc catctcgaaa 130080
cggatactgc gacaactagg aacggaacat caagttttgg tgatcgcatc agaagttttt 130140
gtgagagggc tcgctcctta atttccaact ttgtaacatg gcgtagtaga aacgagagct 130200
gtgaggttct ggcagagatt ccacaagaga aagaagtgga atcgaccctc tgaatccagt 130260
ataaatagta gctaggcggg ataatgagtc gctgtttgca cattatcaaa gctacgcatt 130320
agataactgc agaaagacgc tgcgtatagt tatgtattct tagaatacgt ctgtatatac 130380
gcacgaacat ataagtctgt aagaatgtaa tgcttcgtac agatcactgt ttattgaagt 130440
tcaacggtat gaaatttgag tatacctaga attagcagga ataattggca tctcaatttc 130500
tcgaggcttt ttttttgcac attgacatct accggaaaag tgtgtatgcg attcgcttac 130560
ccttccccaa ctttctctgt cggtcgtggt atattgaggc cggtgtatgt agagagtcta 130620
cgatcttcga tctcccttcg gatcacatgg agcggagatg ttgtagggtt cgagaggggt 130680
gagacctaaa catgcagtcg catgcatgtg gaacacgatt ggccgttgta gcatacaagc 130740
agtacacatg gcgaaagttt gccgtccgcc tgttcggtgt gacgtcatgt ttaggtttga 130800
gcatgtaaga aaaatggaac tgttaactct aaaaagaagt atctcgcccc atttgtatca 130860
ttcggcggtg ggaaatatag gtaataggaa aaatcatacc tacgtcaggc ttcttcgtct 130920
gcgatcgcag aagtgtctgg agacgcgcaa agaaggtctg gcgcattccg atatagtttg 130980
cagccaatgc ttggtccgcg gaatcgggat cggagccgat tatcgataat acggaagcaa 131040
aggggataac ttccttgttt acatagaatg tatgaccgga cacgacaaca cggaaatcct 131100
gtctcaaagt ctttgtttgc ggaaatagaa cggatatgac gcttctgtaa acgattgcgg 131160
aagtacggcg gtcgccgaga cgaacgcgga cgtgtagcgg ggacgttcat tgtctttgtt 131220
tttctaatta ttttgaatgt atgtatattt ttcagcctca tcctgtaaat cggtcgagca 131280
ttaaaaggtt acggatattg gttcactgta tgcgtgttca ttttatcttt cgtatactcc 131340
ccttcgcgta cggtacgatc aaggttaaaa aaagttactg caaatgtaca gtaaccgccg 131400
taaattaact tgcggtgtcg gttgcttcat gcgtctcgat atatgttctg tgcgcttctc 131460
aactagctgg cggcatctac aatttttgtc tgtttgtcgt ttgccactaa actcaatgat 131520
ttccggacca gtagcggcgg gggagggggt gtgttatatt tcgagagcgt tcggccgggt 131580
ttgatcctgg aattatgaaa ccgtgccgac tgcgttttta tttttgttgt tgttattcta 131640
tacgttccaa tggcgcgaaa tggggtagtt ttttttgcgg cagctcctca ggatttatac 131700
ggaattgttt ataacgtcat tgggtattga aggtatttcc ttttattata agtttttttt 131760
taagtcgctg ttcccatgag aaatttttga taactgatat tgcttactca tagctgatgc 131820
ccggaatttt agcttaagtg aatcacctta tagtgcagtg cctttgatgt ctggggccct 131880
gatagacaga tgccctttct taagtgctga tttatcatct cattacccct cgcctcagca 131940
taaatatgcg atcggtgtga cgattactca gaaccgctct tcctaattag cagaaccagc 132000
gaattatact ttagaggcct ttatgtcgag aggccctgga aattttaccg cccccgaaca 132060
ctttccaact aactgtcgat ttgtcatcta gagactctta tcggttgaag gtgcgatctg 132120
tgggcttgat tacgcataat cgtgcgcgaa ttgccctgtt cggccaatcg aatttctaat 132180
acataccttt catacaggat ctggctgcgc gccagttatt ctacttaagg ctcagtccgt 132240
ccgctccccg atcttttcgc ccgatccctc taccagccgg cttttcgatc gtgacattta 132300
gaaccaaagt gcgggtaagg taatcattcc cggataacta agagacctga tctccgggag 132360
tgtaacatat cgggtagatc taatgaagtg ggtcaaacaa aatgggaaag tagattttaa 132420
actttttcta gtctactcat atacatttcc gtacgcgggc gatgcacgag ataattctca 132480
ttcggatata taatttgtgc cggagcggtt tttctccttc cccccggagt tcactgtatc 132540
gtacgttgta aactccgagg gcaggaaaaa gtgccccgac tcacatactt caaaatataa 132600
tttttgaagg ctaatgagca tcgtggggga ggggggttgt atgtgtgtga gcagtcggtt 132660
gtaaccaata ttaggagaac gtgaaaaaaa aagagggggg agacggactc gagcctttta 132720
aaagtttatc aactgtcatg aaccgtatgc gatcacattg acacggttta aaatacatac 132780
gtgtgtatcg tggtcgtcta ctgtttgtgg tggtattgaa acatcttcag ggtttcagac 132840
atagttgttg ttaggataaa agaatagttg gtgcgataaa tacaatcgat acattatttt 132900
cttccccccc ccccccccgt gttacaaatt cgcgttgttt gagatatggg acggtgggtg 132960
agcaggatgg gaaaatgatc aaggcctggc ggtataatta atggagaggg gataatgccc 133020
tcgccgatca aggccctccg tataatgtaa atgtccaaag gtttgcataa tacggagggt 133080
tctgatccga gtggccgatc gtacgcgagg ccaaaagtcc ttagcgatga tatgagccag 133140
acttactgtg gccacgtact gacgaattta gtacctgtcg tctgcattgt tcttgatcag 133200
gattcactac aggcggcatg aaaatgtgaa acctctcccg ctagaaatag aatctgctgg 133260
gggggttcac atttttaagt tgtatgtagt gtatcggtct tcgtgacacc gcgtatcgcg 133320
agagcgatcc gacggccgca ttgtactttg tatattctcc taaaagaaag ttgtattctg 133380
cccggtagtc cgtttgtaag gtcttggaac ggactgccgc agaatagctt tcttgagggg 133440
agcgatcgac tcgagacgtg ttccacgtga cggctctggg cttgttttga atgtcccctg 133500
tgaagtttaa tgctgtatcg gaacccttcg ttcggtgacc acgaatggtt ctgacagcat 133560
gacctttctg ggggaaatga tcgctggaaa accatcgtag aacgtctata caccgttgaa 133620
gtgatgtaat attgaatcgg atttggaata accgaattcg gtgatataaa gacgatagtc 133680
atgcatgacg tggggggctg gatcgactga tatctaatgg ttcgggagtg atacggagac 133740
ggggggggga aatgatcgat ttatacctac ctcttaaata aactattgct cctttataaa 133800
atgacaggtg aattgtgacc gttcgcgaac gtgtaattct tcaatacttt cgggtctgtg 133860
ggtgttgctt ttttaattat tattttggtt cggggaggtt ggtgctggaa tgttaagaat 133920
aaattccgca cactgattcc taggcaggcg tctcttgcag gtgtatacca gggagaaggc 133980
gggcacggta caggtgtaaa gagatgtctc aggagccaga gccgggcgct atgccctaca 134040
gtcccgctga cgatccgtcc cccctcgatc tttctctcgg gtcgacttcg agacggaaaa 134100
aaaggaaaag tcacgacatc cccaacagcc cctccaaaca ccccttccct gacggcctat 134160
ctgaggagga gaaacagaag ctggaaagga ggagaaaaag gaatcgtgac gccgctcgga 134220
gaagacgcag ggagcagacg tactatgtag acaaactcca tgaagcatgt gaagagctgc 134280
agagggccaa tgaacaccta cgtaaggaaa ttcgagatct aaggactgag tgcacgtccc 134340
tgcgtgcaca gttggcttgt catgagccag tttgccctat ggcggtaccc ctaacggtga 134400
cccttggact gcttaccacc ccgcacgatc ccgttcctga acctcccatt tgcactcctc 134460
cacctccctc accggatgaa cctaacgctc cacattgctc cggttcccaa cctcctatct 134520
gtaccccccc tactcccgat acggaggaac tttgcgccca gctctgctcg accccaccac 134580
ctcccatctc tactccccat attatctacg ctccggggcc ttcccccctc caacctccta 134640
tctgtacccc cgctcctccc gatgcggagg agctttgcgc ccagctctgc tcgaccccac 134700
cacctcccat ctgtactccc cattccctct tctgccctcc ccagcctcca tctccggagg 134760
gcatcttccc tgcattgtgt cctgttaccg agccgtgtac ccctccatcg ccggggacgg 134820
tttacgctca gctttgtcct gttggccagg ctcccctttt taccccatct cccccacatc 134880
cggctccgga gccggagagg ctttatgctc gtcttaccga ggatcccgaa caggattcct 134940
tgtattcggg ccagatttat attcagtttc cctcggatac tcagtctacg gtctggtggt 135000
ttccaggtga cgggagaccc tgatgatccg cattgtgact ctcagcagca catcgtctat 135060
gccccatgtt tcttctcccc tagttatata taatagtttt catagtttcg ggaagatcaa 135120
cataaaggaa agggttaaag gcattattta tcgatttact gacataaaaa aatcctctgg 135180
ggtaacaaat tttccttacc gtgtagctta gactcggaag aactattttg agttacatgg 135240
tcaggggatt tgttggctcc aggagttccg aagtatgaga taaacttagc tatgtggaaa 135300
acttctgggg caacatctct cggccccaga ctgcttaaat ggcaaattct cgttctatac 135360
agaacggttg gggaagggga ggggggggta tatggagtat tattcgggat atggcttcta 135420
tgaagcctgc ggtaagtttt ccaggctcaa aaactatgcc tggctgtttt ttttttagaa 135480
gggatatgga catcgcacat taaggaatat taaagataac aggatggaca ttcggatgta 135540
aaaggaataa gcgaaacctt tagcagatgt gagttaatgc agtctcgtat aattcggtgg 135600
tgctgattag gttatcgtaa ggaacaacac gattgatctc tcatccgcgt cccagcaatc 135660
aggcctatgt ccctctcctg tggccagctc actggctgtg cactgtgcga ttctaagtgc 135720
tacagtcgtg agcagatcaa tggatcgggg ctcgcgcaac actactgtaa ttaaatattc 135780
gtttatgaat tatgcaaata tgcacagata atatatacag ggatgcacag acatactcct 135840
atgcaccgat acacaggcac ataggcagat gtcgacatta acgaatatac aggcacggac 135900
ctccaggaac atatggaaaa tacctcatcg cagagacgct tatgcaggag taatctgcgt 135960
taagtcgtta ctggattgta acggctatcc ggagactctc ttcccctttt gcttgttcac 136020
tgtgcggcat tattacattt acaccggtaa tgctgcgcat gaaagagcga acggaacgag 136080
gctcgtacga cattacaaga atagtttgaa ttctcgggat aatctcccga tggcctcccc 136140
cttatgcttt ctctacgatg tggcattgtt tacgcggcag tgccacgtgt gaggggacga 136200
tcgggacggg atccattacg taaaatttag atcttttgta gaaattcaat tcccttcccc 136260
ttttactttg tttgatgtgt gccactgttg taccgatagt gccgcgcgtg aaagagtgaa 136320
cgggaagggc ttacgtaaag aactgtcggt gccggtacgg ggggaagctg taacgcattt 136380
cgagtcttga taaagcagag catgaaaatt aaatcgtagc tcctaaaaac taacggttcg 136440
tgggtttttt tttaccttag tgcgtttgtt gacggaaatg tccgccatta tttgaacgtc 136500
tgtgcgcatg cgcgatgagt gcgcagggcg tatatagcgc aagcgcgcag ggctggttcg 136560
ggtaaggcgt tcacgcatgc gccagttatg catgacgcgc atgcgtatgg tggagtgtat 136620
ctgcgcatgc gcgtgtgtcg aaaaccaggc atgcgcagat aaccatactt acggcgcatg 136680
tttgttttgg gtaattggtc tgcgcatgcg ttttgtgtgt agagggcgca tgcgtactgc 136740
cgtaagcggt ctgcgcatgc gttttggact gcgcatgcgt tttgtgtgta gagggcgcat 136800
gcgtactgca gtaagtggtc tgcgcatgcg ggtcgtgtgt agagggcgca tgcgtactgc 136860
aaaatttatt gtggtcctgg ttttctgcta tgcaggggtc gtgggaattt tctcatatac 136920
atttaagggt cctcatagtc ttgtgttcca gtattatcac cttttgatgc aaactcctgt 136980
tcattttagt gtttcgatgc tatagtttat gccccatcga atggaaattt tcaataaaca 137040
aaatgcatct cacggtcgtg gaattttaag ttgggggtct ccaatatcac gtgttgttgg 137100
agacccaata acagggaaat cgcccgaggc attacgggta cggttccatg gatatataat 137160
gcagggggtg tgggtttgat gagcagttgg ggcggcaaaa atgcaggcgt cgttgctagt 137220
attggttcta ttcatagtac agatctattt gttgcctgga aatggtaagt aggggaagag 137280
aactctagac tggaggttgt ggaatacgct atactgatgt aaccagtact cgtaaaagct 137340
gaggggtttc gtctctggca tgtgcagcaa tggtggtata aggaaaggta gcacggggga 137400
tggtgttgtt ctgataaatg catgctctta ataatgtagg catatcactg gagagtctcg 137460
ctgtcgacaa gaggtgcaag tgcgtgaaag tcactaatcg gcctactggc ttggggccta 137520
ttatcgctgt tgacgtgata ccaccgagta tacactgcag gaggactgaa attatgtaag 137580
taagctctat tacttggcca aaatatgggg ttgtcatctt aggtgtagtg tctggctgta 137640
aagctaattt ggttaaggtt ttcccttttg tagctttgct ctcaagaaga acaggaaggt 137700
atgtgtggac cctgaggcgc cttgggtaca gcagtttatt aaaaaactag aacgacagca 137760
tcgcacaagg aaggaaaatc tgatggttgg agaagatggt ggcaaatcga ccgtgggacc 137820
ggtaaaaaac acaattgagc ccacacctcc tactattggt tcccatatct gtctttgatt 137880
aattgctacc tcctgtaatt aaaagaaggc actttttttt ccgattttga ctcctcgtac 137940
atatatcgat aatgtagcta ttggatggag cagggatacg gtctacgaac tggatgtagt 138000
aatgcaggca ggtgtacaac tgtctgtcgg ccgcgagagg ttttagggcc ccgcgggttt 138060
attcagtgct gcgccgattc tacccgcagg actcgcacat ttctgagggt atcggacttc 138120
tctatcccca catattctag caacggttct ccatcgcgca attaaagcac gattaagtac 138180
cccaagttca ctgactcttc gtgcaaaagg gggaaaaaag aaagccgaga ccacaagatg 138240
gcactgaccc cgtgcacggg gatctgcggg acgggtgatg acccgggggc atcgcactgc 138300
gctcagccca agccccaggg ccacgtcttt gtgcacgctc atgccctgca cggcccacac 138360
gtgtgcccac gcttattgcg gagcgtgccg aggcagagga cggctcctgc cgggacaggg 138420
ctccgcgctg cgcaccgcca cacgtccagg ccaggactcg gcgcctgggc gcccggcacg 138480
gccgcggacg gaccccggta gccccgagcg gcgcccagcg ggcaccacct gcgcagggac 138540
cgggctcgag cgcccacctc cgcggggggc ccgttcggtc tactcacaga gccccgcgcg 138600
cggctcaacg gctccaacgg tcgtgcgcgc ggggccgcgc gtgtgggagc gacgccgtcc 138660
gcgcgcccca cggcgcaggg gggcgcgggg gttgccccgg gggcgccgct cccgtgttgc 138720
tctgctgggg gcgcggggcc gcgcgccgca tctcccgggc gccgccgagg ctgacagagg 138780
cgaactcttc gcggcggcaa tggcgggtgc cggccgaccg cggcctgcgg gcgaggaccc 138840
cagggcggat gggggcgaga ggacccctcg ctgacgtttt ttttttttgt ttgccgtgga 138900
gcccctttcg gtcctttctc ccgcgtccgc cccaccccct ccccgccgcg gcgccccctg 138960
gggcggctcc cctagcccgc tgaaagtcag cgagtaaaca gcgggcggag ggagcgcggc 139020
gacagtacca tcaatacctc cgattagggt tagacacagc ggagccttcc acccgccacg 139080
tgtgccgggg gaaccccgcg tggggctctt gtagcttcct ccgcctacgc ccaccgcgcg 139140
cctattggcc gggctgtacg ctgccgcgta gctattggcg gcggggagga gagcgagcag 139200
agaggggccg gtgcgggagt ttggaactcc gcggtcattc atctcccgcc acgccccatg 139260
cacgtgcccc gccccttcct gtgggccggg gtctgcggga tcggatccgg gggctgcgag 139320
atgcgggctg agctttcccg ccctggattt agcgcagaac ctcgttaaaa catgtcctgt 139380
atctacctat aggaagagcg ttcgagttat tggatggagc agggatgtgg tctacggacc 139440
ggatgtagta gtgcaggcag gtgtacaact gcctgtcggc cgcgagaggt ttttgggggt 139500
tagggttagg gttagggtta gggttagggt tagggtgggg ggtcgagaaa cagggggggt 139560
ctaatttcac accacggagt caccacttgc ataatccaag tttgcgtcac atcacaggtg 139620
gtatgtgccg gttccagtgt ggatttccgt cctttgagct cgggatcgag actaggttca 139680
cggttaagac atcgtcagta tgagtgggaa agtgtcttat cgcccccgga ttctcccatc 139740
ctctacatta tatttggctt attttggatg ggggtggggg ggggtgaaaa tttgaggggt 139800
tagggttagg gttagggtta gggttagggt tagggttagg gttagggtta gggttagggt 139860
tagggttagg gttagggtta gggttagggt tagggttagg gttagggtta gggttggggt 139920
tagggttagg gttagggtta gggttagggt tagggttagg gttagggtta gggttagggt 139980
tagggttagg gttagggtta gggttagggt tagggttagg gttagggtta gggttagggt 140040
tagggttagg gttagggtta gggttcaggc ctagggttag ggttcaggtc tagggttagg 140100
gatcggttgg ccgctagggg ttcgacgaaa tttttttttt tatacagtgt gtggccgcga 140160
gagggttaga gggcgcgtgc gcagtcgtag ttttcctatt ttcggccccg cgcatgcgcg 140220
gtcatgtagg gggcgcgtgc gcagtcgtag ttttcctatt ttcggccccg cgcatgcgcg 140280
gtcatgtaga gggcgcgtgc gcagtcgtag ttttcctatt ttcggccccg cgcatgcgcg 140340
gtcatgtaga gggcgcgtgc gcagtcgtag ttttcctatt ttcggccccg cgcatgcgcg 140400
gtcatgtaga gggcgcgtgc gcagtcgtag ttttcctatt ttcggccccg cgcatgcgcg 140460
gtcatgtaga gggcgcgtgc gcagtcgtag ttttcctatt ttcggccccg cgcatgcgcg 140520
gtcatgtaga gggcgcgtgc gcagtcgtag ttttcctatt ttcggccccg cgcatgcgcg 140580
gtcatgtaga gggcgcgttc ctgatttcct tccgctaccc gtgcgtttgg cacaagtttg 140640
gcggcagctc cagcatccgt ttttggaact cgattccgat taccgcaggt ctctcggact 140700
agttgagagg gtaagtgttt tgtttttgtt ttattaattt gttctgtgtt tccttctccc 140760
tatacaaacg tgtttgttaa tttataggct tgtatgcccc gcttcatttc actcattatg 140820
taggcgttac actgaccttt gcactgcgtc ggggatctat gggtttctgt gtgcttacta 140880
cgattttaaa cttgttattt tacggtttga atttttaata cttgtcctcg ttgaatagat 140940
gatagcctgt taatagattt gagtcaggca ttgcggagtt atatgttacg cggttcccag 141000
cctataagaa tcgtggtgtt ggcgccaaaa aatgcgcgcc aacaaaaagg cgccaaaaaa 141060
ttgcgcgcca ttgtttggcg cctttttccg cgccgttttc aaaatcgcgc cataccaatt 141120
tcaaagttcc cgccatttgg ccaacacgct attatccctg catgatcttc tttaattgga 141180
cgacattcct cgattcccga tccacatatc cagtgacagg agttcggaat aaacgttgtg 141240
atacgcgatc gagttttcgt ggcatattcc tacggaaacc tattgttctg tggttggttt 141300
cgatctatcg ttctcgtact gcgtgacctc tacggaacaa tagttttcca ggagatttcc 141360
cggtttcgac tgccgaagca tggaaacgtc ctgggaaaat ctgttgttcc gtagtgttct 141420
cgtgacacta actcgagatc cctgcgaaat gacagttttc tctgggaatt acatcgtcct 141480
gattgtcgcg acatggaatg gaagcctcat aggaagaact cgatgtgatg atgctctcta 141540
gccaagagag ccgcgaacgc tccaaggaga actgttatct cggggagatc tcgatctctc 141600
ctaccagcaa ctcgagatct ctacgagatt acagtttttg ggggaaatgt gtcctcagaa 141660
ctgcttaatc gtagaagctt cctagtggat ggcgttgtct cgtagaggtc ccgatctctc 141720
ctgttggcaa ctcgaaatct ctacgagata acagtttgtc taggaaactt tcctcccaac 141780
taaagagcga tgacttagga agtaaacgtg ccctcatcac cgcccttaca cactgctagt 141840
cattcatgta cattgcgatt gtgccttggt gcggggcggt tcctaggcac catttatctt 141900
atattcctgt acatcccctc cttaatactt taattggagc cacatcgttt tgccatgttg 141960
atctgtttcc tttccctgta acaatggtta cattctaaac gaactaactt gctttgaaga 142020
aatctacgaa ttgatagact gtatatgcgc cccttttctt tattaaaaac gcttaacaag 142080
gtaacaatat acgtaacatt cgaacaagta ccaagataac tatataacgg cttatataac 142140
tatctttttt atttagacaa gtcacaacta tgttcttttt tttatcactg tgttctcggt 142200
ccggagatca ttgtcgttcc aggtgcatgt ggttcgtccg atagatcgta gcgtggcgaa 142260
agcaccggag cagtctcagg aattacaatg cgcctgtaaa accggctagg cttccgacat 142320
agacgcggtg gcctgtcccc cgagtgccat tcttctggat ctgatgcagc gcaatgttct 142380
cttgcgtctg ccgacgggcg agctcggtca acgtaagtgt cattaacggc ctgtgttgac 142440
ccgctgtcgt ggcgtaaaaa cgaacatggt tcattctcct gttttacagg agtaagggat 142500
attcccgaca taggggacgg tgtacagagt ttcagcagta gtatcgcttc cgtcctagta 142560
atgaaaattt tttgtgctca ccctttaatt tatcatccct ttagccattc ttgacaaatt 142620
cgaatttgac aacacatatt caccaacttc taaggttttt acacctcata gcatgtacac 142680
aatatacaaa tgtgatgatc tcagtgaaat gctatgacta aaatggaggg aaatgtacat 142740
gggatggatg tgtacaggac aatgtaaagg aagtactata tatacagatt ggagggcgaa 142800
ttgagtgatt catactagtt cgacacttgt ctaaattgtt atgaggtttg gggacaatat 142860
ttattgacta gtctgtaaag gtcgtgtccc gattccctat gtttaatgga gacatgtatg 142920
gaggtttagt ggggggtcga actttcattg cccgaatgtc cgaattttcc tgggctgtgg 142980
tttccggacc accttcctca tgctgtcccc aggtaataca actgcttcga attgaggcta 143040
ccatatcttc tgctagagcg gaacatgttc cctcgggaat gtgaacaaca accggcctgg 143100
cctctggatc tggaggtaat attacagacc gacaaagatt acgagccgtc ggatgtaaga 143160
aagaggggga aacgatcgca ttcattttag attcaatcac atatatgggt ctcagggggg 143220
cacataaacc ccattttcgt gcagctcggt tagaatatgt ctcgccgcag agaaagtctg 143280
gcctcacgtg tttaactgca gtaaaataaa agaggggagt agtaggaacg caagatacgt 143340
cttccaggcg cgtttcgact gtataccgga cattgccggt acaacataga ttgatggtac 143400
tgtcctctat cccaatttca cagtaataat actgttctag atccgtgaga gttaatgggc 143460
cgacaacatc ccgcgaggtt ataatagtgg tcccgaaatc gcgaaggccg ggccagcgga 143520
cacagcactg actacggggt gaaattatac atttcatgta acgtgtcgct tcttcaatga 143580
tacatggacc gtttggtagt ctatatcgat cttctaccgt atccatgatt ataagtttct 143640
ttttacgttt catacattga cgttgtaggt attccacagc accctgatag cccaaatcct 143700
ctgttgataa aaacaggact cccatccgag tcagtggaga tatatcgggt gctgctttcc 143760
atcggccagc ccacgcactg ctctcgggta agcataatcg gttagaaaat gcagcaagga 143820
ggaatgataa tcctcctcgc ttattatcaa acttcggccc tcccggggga gtatctggag 143880
cgggtacgca aaacaggtgt tcgcctggga ggggtgagta taaaacaacg atagacacat 143940
catcgggaga ttcttgttgg tatcgcatcc aagcagtcct tgctctaagc attgaagtgg 144000
ctgtgtgaaa tgcctcagat gcagcgctag ttataatttc gttactatta tattttccag 144060
gtaacgcatt tgcgacacga gcgatgtctg ccatagcctc gggagaatag cgcaacacct 144120
cttgccatgg ttcggggatt ctggcaaact ctactagttc cacaaatgcc ccgttggggc 144180
agtatgcgtt cagaacagat tggggagggg tttgaccgat caccgttcca accgggaatt 144240
gcctgaatgc ggcacggtcc tgacgtcccc gtgggcctac taaggccccg gtcataatat 144300
cggtaggact atagcaggac gggtggtatg ggcgtttgga tggggacggg ctgctactgc 144360
aagagcggtt tggaagggaa cttgatagaa tatcgtgggt tgtggtggta gggtcaagca 144420
gtgtttgtcc gaccgacggt tccggcattg ggagtggtgt ctgcaaaccc tgtttgtatt 144480
gctcgggagc tgacttgcgc ttacgggaaa ctccaccaat atcagaaggg gtactagact 144540
gggcagatct gcgtcgctcc ttgctagaaa cggcgggtcc agtgtataag ttctttcgtt 144600
ccagagagga tgattggtcc atagccgagg gatgggcggt gctagtttct ggcaatgtct 144660
catccgtctg tgctttagcc gaggctttaa tccgagtctt tgtcggatct tttagcgaaa 144720
tagtatcact agaagtttta ttcccttttt tagccggggt tggagtagag ctgcaactgt 144780
gcccatttgc cgcaggctgt actgggccgg acattgtgtt ctcgtgtggc gttccggcag 144840
ggtccctttc gggtcttggg gtgcttatcg gtattggatc gcttgtatgt cggtgggtgg 144900
atttaatggg agatttatca gacgcagact gggatgatga agtggagcgt cggggacgcc 144960
caggacctcg aaacagctga tcgggtctcc gtggtggagc aaatacccca taagtgccct 145020
ttgaactccg cccatcgtta agcaactccg ctgtgcggcg caggtgcttg gcctttacaa 145080
ggccaggatc accatcgtcc gttccgcgcc agtctcgtag taagagagaa gtaatgtccc 145140
ttgaccccat gcgcacccac gctcgatctg ggtcttgtct aaccaaaggt ccgatagttt 145200
ctgcaatcag tgataccacg cgagctgcaa gagcacgctc atcgagatgt tgagaggtag 145260
gcgtgtttcc atacgcgcca taaacagctg ctctgagatc cgataattca tggtaccagg 145320
agacgaggag aatacggcat ttctcccatt gttgcaaatc gggaacgtgc ggtgtaatac 145380
gcgagtcgta aaaagataac attttagcta ctctatgcgg cccgtctgga ccacatagga 145440
gcgcggccac tacactatcg caggccaaaa cacaagcatc tgcgagttct tccaagggtc 145500
tggctgcgtc gaattcttcg acaaggcagt cgggacgtgt gcatcccgca aaactaaatt 145560
cggggtcatc aagagatccg tccgccagac acctactcaa gtccacaaca ctttggtata 145620
cgcgtccatg gattgccgtc acatcaattt taggggcatg tgggggtgcg gttgtttggg 145680
tagatgtggt tatcaaaacc gatggcgacg ttgagggttt agatgagatt cccttttccg 145740
tttcggaaga gttatctgga aaagccattg atgcatatgc tttcttaagg gaacggaaca 145800
gaaaggtttt ttggtctttg caatacctgc gtgtcatagc tatactcgcg gctatatgcg 145860
gaaacgccca taataatttt ctctctttca tggcaccagc tatgtgaggg atgcatctgt 145920
taactgtgcc agttacagcc gctccgggcg aatcgtatga actctggaat ttctgaacat 145980
atatgtggtt tagggcagca tcggcgggag acagcttccc gtggtgcatc cagttcagag 146040
gatttacttt catgcttttg tgaaacaaag agtttacgag agcgtcgtat tgtttggcat 146100
aatctttcat ttcctctaca tagacgggaa ctgggccatg ggatgtgttg aatctgtgga 146160
tagcttctac tatctctgga ctatccgtaa gtgcttgtcg atgcccacca aggccaccga 146220
accagcaccg gccaggcggt ggcaacggaa cctcccacca tacgcttccg cagaggtcat 146280
agggggacgt gtccgcaagg ccagaggagg atgtcacctg aatatcattg cgttggacgg 146340
ctcggccgga cttgggagga cgcccacgtg ggcgtcctcc tccacgcctg tttgcggttt 146400
cttggggtaa gtagtcctca tcttccagtt tgcgcgttcg gggcgatgct tttctcccct 146460
tagactgcgg tccggatcgc ccaccacgat tactacctct gccccgacgc gggcggctcg 146520
aagaatcagc ccgcggtctg gggggcgacg gagatggtga cctagatgat gaaggtgagg 146580
acaggacgat tagagaagat gatgacggtg aggatgatga agaggaggaa gatgaagagg 146640
atggcgatct ggaaacatgt ccgacgttcc ggtgagtagt attggatggg ggattccggg 146700
gaggggatat aataatgtgc tcatttgacg gtgaagtctc agggccgcgt ggtctggggg 146760
aacttcgtgg agatgaggtt gtgtgaggca gttcgctcat tctgccagaa gatggagtag 146820
tcagccgtgg acctgaggtg agtggtgcag gtaagtctcc acagaaatct ttctttggcc 146880
cagaacgagg gggacttggg cgccagtctg tggacggatt attccaatct ggaacgggaa 146940
gaggggggaa catgggctgc ccgtcatcgt ccatattggc gttgcaacgg agctgctgga 147000
accgccgtcg ggctgctaat gttacggcag cacgccagtc gcataaagct ttgtataggg 147060
gccggactcg cttttcgatg gcgggaccgt acgccgggaa ccccaactcg accatcgcga 147120
tagcgagttg ttggaccata aaggcatagg aaactttgga gtcccggcgt tctccagact 147180
cgcttccatc tccagtctgt atattatttc tattcctaag ctcaactcta gcttcgcgaa 147240
tggccgcgga gagcgcagga ggcagcgtgg tagatggttg tggcatctca aaagtaactt 147300
cgcagccagg tattacagag ttttctgtaa ggtaattctc gagggccatc acaaacccct 147360
tacgtacatt ataaaaaagg tatctgtaat gcaggcattt aaagtctttc catgccaaac 147420
cggtccaggg attggtgctt ccatctcggc cgtccaccca ggtaatctcg gtgagtacgg 147480
ggcaataatt gtcggagtag aattggccgc aatgcctaag gcggtcggga atagtaggac 147540
acctagtagc gggaatccca taccaatcct catccagagg agtgcctgca cctggtgggg 147600
gtgcacatgc cggaaaacac ggcaggccct gagctgcttg cagctgatat gaaaaatctt 147660
gtgtaaggat gtacgccata tactggacac gtctaagaca acggagccgg tccaacaaac 147720
ggtaggaaag gcgtggaacc ttaaacacaa attcgggggt aacacgaagc cccagaaatc 147780
gaagaaaagc tgatataata tatgcatact tgggaatttg gagggcggga gtagggagcc 147840
gcgcagctgc ttcccacaca catgatggga gagttaccat acccggggga ggtaccgggc 147900
attcgcttct agggccccaa ccacagccac gagaccccag gacgttctca tgactctcgg 147960
aatgcagtgc atcatcgagc acagaaagca cgagtcggga acagcgtgag aacaaccaga 148020
ttttacagcc cacccagtcc ttcgatagtt cacatatagg ttctgggaag tctggaaggg 148080
gaggtgcata attgcactcc acatcccaat caaacggttt ataatcgccg tcaagcagag 148140
ggggttccct cggcagttcg attatccggg gacatttctg gggggagcta gtatggggtg 148200
ggggtagaat ctcccttaat aaagcttccg ttgccaaacg atcccagtag gcagagcagc 148260
ggtgggtatc tggcagtgtt aggagaaagc ttctcatgtt ttgtctccct gcccgtttta 148320
gttcctcggg caaggggctg aatccatcgg gatcatggag ccacaattta gcataactac 148380
caggcaaatg ttttatcagt tcgacttctt ctctgggggg agatgggatt gcaacggaag 148440
ttgacaggcg atacacatac cgaaagccgg ccccccgtac tcggggggct gcaacttccc 148500
gtctgaaatc tgcgctccga cctaaactag ggacgggaca actctgtggc tgggatgaga 148560
tagaatgacg aggggggtcc gggcttggag caagttctcc gggagacaaa ggaggtgggg 148620
acgatggggg tgatacgggg gcgggggaca attgtggagg agaagagagg ggagaagagg 148680
agaggggaga aggtgcaagg tgcgaggggg aacaagaact ggaggaatgc gcaggcggag 148740
acggagcctg gggagggctc gggggggatt ggggctgtat aaattcgacc ggagttattg 148800
gagaaaatat caaggggagg agcgctgggg gctggacggg agaggaaatg ggggcaggtg 148860
agggaaggca tgctgggggc tgagtgggag atggaatggg agcaggtgag gtggaagtag 148920
ggggggtagg cgaatttgtg tgcaagattt gggcagaagc agtggacgtt tccgggcaga 148980
gtggatcaga gtttgactgg ttcgcgggag ctaaatgcgg gtatcgacta tcgaaagctg 149040
accagaaaac gggagagggt gccctcaagg cgctcgccgc cgtatctgcc aattgcctct 149100
ccgaggccct attgaccgac tggggactca acaaaactag gagttcatct atgtcctctg 149160
aagtagtggg gcttatttca tccattccat agaaataagc cttgaacctg ggatcggctc 149220
tcagatagta atcgggatct agcgccttgg tgtcctcacc aaaatcggct gccaggatct 149280
ccagtagagg aggactggat gtcccgccgc ttccggaagc ggactcgatg tccccggatt 149340
cgggggaacc gtcaacagat gaacgatagg aactaacgcg atcggggtcg cagtagctat 149400
cgcaggggct ataagaaggg gaacggtcac tggaactctc accagattca tctgcgccgt 149460
ttgaggagtt acgaccgccg gggcgattgc tggaagtatc ggtggtgggg cccgcggtat 149520
cgcagactgc tcgggtggct gcgggagggg cagcggcggc aacgccgttg gacgtcgagt 149580
gctgtccagg ccgaccggag cgtgggctat gggcagcggg gacggggccg ctggaaagcg 149640
agcgctgtcc atggtaactg gagtgggggc ggtatgtacc cgattgtccg gctagcgatg 149700
gtacggggac acagggtgtt tgcagcgaga cgccttgata agggtccccc ggagtggctg 149760
gcgtatgtgg aaaaatcccc acgtcttcgt caaaagctgc caacaagctg tcgaaatcag 149820
gcgggttgtc catttttagg gtttaggagg ggcgcaaata gatggtgggt gggccgatgt 149880
gaggggaata cggaaggcgt agctgtctat gactcccttt gggggtctcg tggaaatggc 149940
cctcccatgc tagaccacaa gatgtggggg gagggaagct acggttcaag tgcggaaatt 150000
tcgatgtgct gaaagtcgaa acataaatgt aggtgtcagc tgcggatata atcccgaaca 150060
gctagcatct ggttttgtat ttaggccatg ctccaatacc aggcccgctc cacagcattg 150120
ttatacgtat ctgattgctg cccgagatgg atgtcgcggc taatgttctc gatccccccc 150180
ccccccccaa ttgcaaagtg cggtatcagg tttgtacccg cgccggtgta cttcaaatag 150240
tttaaatgcc agcattgcat ttctagcaca caaactagac cggcccaccg agtcaaattg 150300
tgtcctgctg aacgattgca tagtttgaga tggccatgcc cagtaaacaa atacttgaat 150360
accatcgact aagcacaaaa ggctcttatc atctactagc agagttgtga agtagatgag 150420
cgattgtggg gcccagccga ccaaagccct gtaggcaaac attcctgtac tgccggttaa 150480
gcagattaaa cactcatcgc tagagccgca aattatttcc cggtgacaac tttatgcggc 150540
ggctgcggtt tgttttaatt aatacctaat gggcaaatat tcacgctccc acaaaataaa 150600
cacaaatcac ccagtgttcc cacatcaaaa atcgccatgt agggaagatg gatttgaaga 150660
tcgcagactc gacagggaac gcgctcaaaa aaaaaaaaaa cggagggatg ggtctttatt 150720
caaagaagtg taaaaggtaa tgcgaccact cgagcagcaa acattaaccg cgcgcttatg 150780
gatactacga gctagcaccg ggaaaggcag tgcatgagtc ccgttgatga atatgggggg 150840
agggggaata ggtcggtaaa acttgtgccc gcagacctcc gacatgaaca gtagactgtt 150900
taatgtagaa cgaaatcgag gagccatacc ggatacattt tgcgggcaag ttcgccatcc 150960
ggttttcaga aaaatcagac ttttgctgaa catcgagagt attattcatc acaaattaaa 151020
aactcgggca tgtctgatcc ttcatgagct ggccaagagg cgacagtaaa aaaaaaaaat 151080
cgaagggggg gaaacattgc tcgataatcg cgtagccaga ccgcaccata ttctccccct 151140
cccgcaaatt cagaattgta taagagaacg taggaaaaaa aaaggaatat acataccaca 151200
cactttgata ttttggatgt gtcccagggc aatgggaaca gcaatcactt tcgaattcct 151260
tcagcccaaa gcacaaccgc gggtccaccg ggactctccg acatagctcg agccaaaagg 151320
gaattgtagc ccaggcaagt gcaatgtttt aatttgttct tctccctccc ccacataaaa 151380
aaaccactgg atcgtacaag tatacgagta tatgggtggg gtgccgtttt atataaacac 151440
agcttagttt gtttgccacg tcaaggaagg gcggtgcata tctgcaagta aacaaaactc 151500
ggggttctgt acgattggcc ggggtcttac atgctcgccg aattggattt gagaatcaat 151560
cttccgacgg gtttcctgac ttgaacaggg gaaaggggga gggggagtgt gttatcttgt 151620
cgcgaaccaa taaaatagat ttgtggccta acgagttctc ttttttttta tatcgcaagt 151680
gttaacgaag ctatgggact agtcttttcg tacaagtctc agacaaaccg cgaccaaaaa 151740
agcgcggccc tgtcgaagag gaaatactga atcgacgagc taaccacagc gtgtctcctg 151800
ggttaacctc tctataggcg gggggaagtc cctcttatat tggcgagtgg cctaggattg 151860
agtggcctag gattgaatat tgaatatgcc tcagttccct acggcgcttt gaggtagagg 151920
gaagttccca gagcttgcat atgcaaacga gatgttgtag gggaaaaaaa aagaggaacc 151980
gtgcctttct ctacgcagat gggtcccccc caaaaaaaaa agggaaccgt gccttcctcc 152040
gcgcaaatag gtgccccacg aggcctcggg gtccgcgggg cggagagggg aaaaagagta 152100
cggttcaggg gatatgagaa cagctgcgta ttttccccgt gcatctcata ccgcccattt 152160
ttgggtagag gtatattttt attagccaaa tcgtattcct ggaagtttga caaaacctgt 152220
caaactgaca cggtccaagc gaaactcgaa aaaaaagggg ggggggagaa tattctgtag 152280
gaccggcaga acttctcaag gcagaggaaa gatacacatt attttttgtt agatttaggc 152340
aagttttgca gaacctgcag ggaatgtata caccatcaaa tctactcgac ttattgcttg 152400
agtccaattt aacagaaatt aaaatatatt gatgttgcga catatgcatc ctcgcatatg 152460
ggggtgggac acaggacgat tatatcccca gacatgaacc tcaaactgcc attttgatcc 152520
catcattgga gagacaaatt cgcatacatc ctacttatcg cacacattgg atgtcggtct 152580
ttattcaggc catatcagct ttcacggggg caaattcgta ttcatagatc cgtcatcgat 152640
gcagcgccaa accggacata tggaagacaa aaagagaacc ggtttggaat cgcaggggac 152700
cgagaatgct ttttcagatg gcagagatgg caaagatgga ttgttacatg aaggaattaa 152760
tgagcccatt ttgattccgt ctaccatcgc agatctcgag gggattcgtg aattggtccg 152820
aaaattccgt ggtcgtctac tgccctttga aaagtgtccc gatttttgtc tgagaattgg 152880
gggtttggag gccagctttc ataaagggca ggaggagctg ttagagtatt gtgaagcact 152940
ttatttacca caacctgtta agatggaaat agtaggcatt gtagacgatg tgccatgtct 153000
ggcaacgggg atgcaattac tcattcttgt tgccgagggg ggagaggtat atgcctatga 153060
agaagatact ctgcataagt tagccacgag tttttccgaa ttccttgaaa ttggagtgaa 153120
atctttaggg agggaggttt accattgtgg agaatatata gagcaagtag tacattaggg 153180
gctgggttaa agaccaagta atttttgacc ggatatcacg tgatgtaaat tctagcaatt 153240
attgttccta gcagaagata aaagctggta gctatataat acaggccaaa gtctccaaat 153300
tacacttgag cagaaaacct gctttcggct ccatcggagg caacatgagt cgtgatcgag 153360
atcgagccag acccgataca cgattatcat cgtcagataa tgagagcgac gacgaagatt 153420
atcaactgcc acattcacat ccggaatatg gcagtgactc gtccgatcaa gactttgaac 153480
ttaataatgt gggcaaattt tgtcctctac catggaaacc cgatgtcgct cggttatgtg 153540
cggatacaaa caaactattt cgatgtttta ttcgatgtcg actaaatagc ggtccgttcc 153600
acgatgctct tcggagagca ctattcgata ttcatatgat tggtcgaatg ggatatcgac 153660
taaaacaagc cgaatgggaa actatcatga atttgacccc acgccaaagt ctacatctgc 153720
gcaggactct gagggatgct gatagtcgaa gcgcccatcc tatatccgat atatatgcct 153780
ccgatagcat ttttcaccca atcgctgcgt cctcgggaac tatttcttca gactgcgatg 153840
taaaaggaat gaacgatttg tcggtagaca gtaaattgca ttaactatcc agacttgaag 153900
agaaagctct tattatataa ttttaattgt tagacataga gccgacattc tttgatctat 153960
ctaatgagat aaaataatag attttggatt tatttgtcat gatctgttgc aacaaacgct 154020
tacccccccc atccatgaag gggcgtgtca aataacgtgt tgcctttttg ttgtatatga 154080
agatatttaa tgtggcgttg agcctaatga gaggagaacg tgtttgaata ctggagacga 154140
gcgccgtgta agattaaaac atattggaga ggtatggcca tgtggtctct acggcgcaaa 154200
tctagcagga gtgtgcaact ccgggtagat tctccaaaag aacagagtta tgatatactt 154260
tctgccggcg gggaacatgt tgcgctattg cctaaatctg tacgcagtct agccaggacc 154320
atattaaccg ccgctacgat ctcccaggct gctatgaaag ctggaaaacc accatcgtct 154380
cgtttgtggg gtgagatatt cgacagaatg actgtcacgc ttaacgaata tgatatttct 154440
gcttcgccat tccacccgac agacccgacg agaaaaattg taggccgggc tttacggtgt 154500
attgaacgtg ctcctcttac acacgaagaa atggacactc ggtttactat catgatgtat 154560
tggtgttgtc ttggacatgc tggatactgt actgtttcgc gcttatatga gaagaatgtc 154620
cgtcttatgg acatagtagg ttcggcaacg ggctgtggaa taagtccact ccccgaaata 154680
gagtcttatt ggaaaccttt atgtcgtgcc gtcgctacta aggggaatgc agcaatcggt 154740
gatgatgctg aattggcaca ttatctgaca aatcttcggg aatcgccaac aggagacggg 154800
gaatcctact tataactaat cgcacaatta ttaataggat tttaggaaaa actgctacta 154860
acgttgttta aataataaaa ttttattttc aataaggcat tacagtgttg tcatgattgt 154920
atgtattata tggggtatgc atgaggatta cttcgattga aactttgtct aaatgtctgt 154980
aggattttac tattcattag tctggatcga ggcggacgta aatggagatt gcggcaaatg 155040
taggggtgct ggtacataag acctccaaca tccattcgac tcatcggcct gcgtccaaat 155100
ggatatgtcg atgtaccttg taaagttatg acattagaag atcgatggtg aatagtggga 155160
tctatatcca tgctattctc aatattgcat gatatgcaat gttcccggtt aggtttgata 155220
agatcatgta tggttctata atacaactcc tcttcagaag aatcatttat tttatgtcca 155280
ctgtccttgg atattccagt ttctgtcaat cgattcgctt gcatttgcgt gcagcatgtc 155340
ttgatggcat ttcctatgct atcatccggc aggcctaagg gtgttctata ctcgcacaca 155400
ggtagagcaa gaaccacggc atatcgagct acctccattg ccccgctaag gacatttctt 155460
gcagactgta ttgtcatgaa catatttcgt gtattgtgtc gatcataacc cttgttgatt 155520
cctatggaaa gcattgtggt ccagttttcc agatgaaatg aaaacaatgc gggcaaaaat 155580
ggtcccacct gtttcatctt caatgcatct ctcacatccc aagttctata gaatattctc 155640
cactgaccag tttcggtaag atcagtttct gtaaaatttg tgatagtttc aatcgaaaac 155700
attttgtcca tcatggcaaa aaatctatag gcagaccaga taaccatttg acaccacata 155760
tccttgtgta tatcaaacga tgtaatagat ccctcgttag tagatatggt acataaaagg 155820
cctaatctct ctcgggcttc catacattga acgattcctt ctgtgaattc atcaacaacc 155880
acatgccaaa aatttacatt agtaatcttt ctcggtggct taccaaatcg tcctcttggt 155940
atatccatat catcgaacat tgtagcattg actctgctca tcgttgtctt tcaaatgcgc 156000
tcgattgttg aatctctcct gatgttagaa gtatatggaa gatagcctgg atacataagt 156060
gatctagaag ggtttgttat tgcactaata tacaaattat acgtgacact atagcgacgg 156120
ttgtagcgat gcacctaatc gtaatgtgta tacgccccat catgtaatta tatctaattg 156180
gtagcaagta ggtctgtcga ataacagcta atgactaccg gctctacatt ttttctgtat 156240
tcgtgacttt cctgtcgcag tgtaacgaac cggaattgca atcgcatctc tatcttcttt 156300
cttgcaacat tttccacaac agaataatct gccgggtgta ctactcattt gaggtggttc 156360
gatttccgga ggttttagag gattgggtgg ggacccgagg attttgtata cacataccat 156420
atcactgtcg caaaaatgcg ctctatcttc tggggtgtcg aacttcggtt cccatgtaga 156480
tgtcaagaga gtttgaatat tgtcgggaat ggcccacggc ataccggacc aggtcccaga 156540
cactttgatt gcaagtaacc tttttggcaa aggaatacat tcgagcgcaa tgcgacatat 156600
atctgccgcc ccaactatcc acaagctatg tggagcatta ccagaaactt cagattccaa 156660
catcaaatat ccagatagaa catcctgcca ttctgtggaa catcctgcaa catcttcaaa 156720
tagccgcact ataaacgaat ccctagttcc ggccaatccg gtaccacgaa ctccagttcc 156780
atctggtggc tttgtcctta ctatcggtcg atgttgccga ggaagaatta acatgggttt 156840
ggcaaaacgg aataggtctg cagctctgac gattatgggc acacccacat catcctgtat 156900
ttgttccata cattgcttta taaggaatat ccataaagta gatgcagcat ctctagatct 156960
tcctggcaat cgatcgcatt catctagaag tgtgactata gttatcatgg acacacccat 157020
cttcacctcc accaataatc ttttttattg ttaataactg ggccggtctg atctccaaat 157080
cttatactct ggtagaatat gaaacagggt taaaactagg taatagactg gatgtcttcg 157140
agtccggagg cagaaacgat ggaatgcggc atttcttcgt cgaaagtaca cgactctaaa 157200
actaatacta cctacggaat tatacataac agcatcaatg gtacggatac gacgttgttt 157260
gatacttttc ccgacagtac cgataacgcg gaagtgacgg gggatgtgga cgatgtgaag 157320
actgagagct ctcccgagtc ccaatctgaa gatttgtcac cttttgggaa cgatggaaat 157380
gaatcccccg aaacggtgac ggacattgat gcagtttcag ctgtgcgaat gcagtataac 157440
attgtttcat cgttaccgcc cggatctgaa gggtatatct atgtttgtac aaagcgtggg 157500
gataatacca agagaaaagt cattgtgaaa gctgtgactg gtggcaaaac ccttgggagt 157560
gaaattgata tattaaaaaa aatgtctcac cgctccataa ttagattagt tcatgcttat 157620
agatggaaat cgacagtttg tatggtaatg cctaaataca aatgcgactt gtttacgtac 157680
atagatatca tgggaccatt gccactaaat caaataatta cgatagaacg gggtttgctt 157740
ggagcattgg catatatcca cgaaaagggt ataatacatc gtgatgtaaa aactgaaaat 157800
atatttttgg acaaacctga aaatgtagta ttgggggact ttggggcagc atgtaaatta 157860
gatgaacata cagataaacc caaatgttat ggatggagtg gaactctgga aaccaattcg 157920
cctgaactgc ttgcacttga tccatactgt acaaaaactg atatatggag tgcaggatta 157980
gttctgtttg agatgtcagt aaaaaatata accttttttg gcaaacaagt aaacggctca 158040
ggttctcagc tgagatccat aattagatgc ctgcaagtcc atccgttgga atttccacag 158100
aacaattcta caaacttatg caaacacttc aagcagtacg cgattcagtt acgacatcca 158160
tatgcaatcc ctcagattat acgaaagagt ggtatgacga tggatcttga atatgctatt 158220
gcaaaaatgc tcacattcga tcaggagttt agaccatctg cccaagatat tttaatgttg 158280
cctcttttta ctaaagaacc cgctgacgca ttatacacga taactgccgc tcatatgtaa 158340
acacccgtca aaaataactt caatgattca ttttataata tatactacgc gttacctgca 158400
ataatgacaa cattcgaagt ctttgaagat tcgcagacct tttttgcgaa tggcaccttc 158460
gggacctacg ccatattccc acagaccgca aataaagcat tatggaacat ttttggattg 158520
catgagatat actctaaacg atgagagtaa ggtagatgat agatgttcag acatacataa 158580
ctccttagca caatccaatg ttacttcaag catgtctgta atgaacgatt cggaagaata 158640
tccattaata aatggacctt cgatgcaggc agaggaccct aaaagtgttt tttataaagt 158700
tcgtaagcct gaccgaagtc gtgatttttc atggcaaaat ctgaactcct atggcaatag 158760
tggtctacgt cgtgaaaaat atatacgttc ctctaagagg cgatggaaga atcccgagat 158820
atttaaggta tctttgaaat gtgaatcaat tggcgctggt aacggaataa aaatttcatt 158880
ctcatttttc taacattata atatatcaga tcgtttctta tatacttatt ttcatcgtcg 158940
ggatatgact aacgtatact aagttacaag aaacaactgc ttaacgtcga acataacgga 159000
aataaaaata tatatagcgt ctcctataac tgttatattg gcacctttta gagcttcggt 159060
atgaatagat acagatatga aagtattttt tttagatata tctcatccac gagaatgatt 159120
cttataatct gtctactttt gggaattgga gacatgtccg caatgggact taagaaagac 159180
aattctccga tcattcccac attacatccg aaaggtaatg aaaacctccg ggctactctc 159240
aatgaataca aaatcccgtc tccactgttt gatacacttg acaattcata tgagacaaaa 159300
cacgtaatat atacggataa ttgcagtttt gctgttttga atccatttgg cgatccgaaa 159360
tatacgcttc tcagtttact gttgatggga cgacgcaaat atgatgctct agtcgcatgg 159420
tttgtcttgg gcagagcatg tgggagacca atttatttac gtgaatatgc caactgctct 159480
actaatgaac catttggaac ttgtaaatta aagtccctag gatggtggga tagaagatat 159540
gcaatgacga gttatatcga tcgagatgaa ttgaaattga ttattgcagc acccagtcgt 159600
gagctaagtg gattatatac gcgtttaata ataattaatg gagaacccat ttcgagtgac 159660
atattactga ctgttaaaga aacatgtagt ttttcgagac gggggataaa ggataacaaa 159720
ctatgcaaac cgttcagttt ttttgtcaat ggtacaacac ggctgttaga catggtggga 159780
acaggaaccc cgagagctca tgaagaaaat gtgaagcagt ggcttgaacg aattggtggt 159840
aaacatctac caatcgtcgt cgaaacatct atgcaacaag tctcaaattt gccgagaagt 159900
tttagagatt catatttaaa atcacctgac gacgataaat ataatgacgt caaaatgaca 159960
tcggccacta ctaataacat taccacctcc gtggatggtt acactggact cactaatcgg 160020
cccgaggact ttgagaaagc accatacata actaaacgac cgataatctc tgtcgaggag 160080
gcatccagtc aatcacctaa aatatcaaca gaaaaaaaat cccgaacgca aataataatt 160140
tcactagttg ttctatgcgt catgttttgt ttcattgtaa tcgggtctgg tatatggatc 160200
cttcgcaaac accgcaaaac ggtgatgtat gatagacgtc gtccatcaag acgggcatat 160260
tcccgcctat aacacgtgtt tggtatgggc gtgtcgctat agtgcataag aagttgacta 160320
cattgatcaa tgacattata tagcttcttt ggtcagatag acggcgtgtg tgattgcgat 160380
gtatgtacta caattattat tttggatccg cctctttcga ggcatctggt ctatagttta 160440
tactggaaca tctgttacgt tatcaacgga ccaatctgct cttgttgcgt tctgcggatt 160500
agataaaatg gtgaatgtac gcggccaact tttattcctg ggcgaccaga ctcggaccag 160560
ttcttataca ggaacgacgg aaatcttgaa atgggatgaa gaatataaat gctattccgt 160620
tctacatgcg acatcatata tggattgtcc tgctatagac gccacggtat tcagaggctg 160680
tagagacgct gtggtatatg ctcaacctca tggtagagta caaccttttc ccgaaaaggg 160740
aacattgttg agaattgtcg aacccagagt atcagataca ggcagctatt acatacgtgt 160800
atctctcgct ggaagaaata tgagcgatat atttagaatg gttgttatta taaggagtag 160860
caaatcttgg gcctgtaatc actctgctag ttcatttcag gcccataaat gtattcgcta 160920
tgtcgaccgt atggcctttg aaaattatct gattggacat gtaggcaatt tgctggacag 160980
tgactcggaa ttgcatgcaa tttataatat tactccccaa tccatttcca cagatattaa 161040
tattgtaacg actccatttt acgataattc gggaacaatt tattcaccta cggtttctaa 161100
tttgtttaat aacaattccc atgtcgatgc aatgaattcg actggtatgt ggaataccgt 161160
tttaaaatat acccttccaa ggcttattta cttttctacg atgattgtac tatgtataat 161220
agcattggca atttatttgg tctgtgaaag gtgccgctct ccccatcgta ggatatacat 161280
cggtgaacca agatctgatg aggccccact catcacttct gcagttaacg aatcatttca 161340
atatgattat aatgtaaagg aaactccttc agatgttatt gaaaaggagt tgatggaaaa 161400
actgaagaag aaagtcgaat tgttggaaag agaagaatgt gtataggttt gagaaactat 161460
tataggtagg tggtacctgt tagcttagta taaggggagg agccgtttct tgttttaaag 161520
acacgaacac aaggccgtaa gttttatatg tgaattttgt gcatgtctgc gagtcagcgt 161580
cataatgtgt gttttccaaa tcctgataat agtgacgacg atcaaagtag ctggaacggc 161640
caacataaat cgtatagacg ttcctgtagg acattctgct acaacgacga tcccgcgata 161700
tccaccagtt gtcgatggga ccctttacac cgagacgtgg acatggattc ccaatcactg 161760
caacgaaacg gcaacaggct atgtatgtct ggaaagtgct cactgtttta ccgatttgat 161820
attaggagta tcctgcatga ggtatgcgga tgaaatcgtc ttacgaactg ataaatttat 161880
tgtcgatgcg ggatccatta aacaaataga atcgctaagt ctgaatggag ttccgaatat 161940
attcctatct acgaaagcaa gtaacaagtt ggagatacta aatgctagcc tacaaaatgc 162000
gggtatctac attcggtatt ctagaaatgg gacgaggact gcaaagctgg atgttgttgt 162060
ggttggcgtt ttgggtcaag caagggatcg cctaccccaa atgtccagtc ctatgatctc 162120
atcccacgcc gatatcaagt tgtcattaaa aaactttaaa gcattagtat atcacgtggg 162180
agatactatc aatgtctcga cggcggttat actaggacct tctccggaga tattcacatt 162240
ggaatttagg gtgttgttcc tccgttataa tccaacgtgc aagttcgtca cgatttatga 162300
accttgtata tttcacccca aagaaccaga gtgtattact actgcagaac aatcggtatg 162360
tcatttcgca tccaacattg acattctgca gatagccgcc gcacgttctg aaaattgtag 162420
cacagggtat cgtagatgta tttatgacac ggctatcgat gaatctgtgc aggccagatt 162480
aaccttcata gaaccaggaa ttccttcctt taaaatgaaa gatgtccagg tagacgatgc 162540
gggattgtat gtggttgtgg ctttatataa tggacgtcca agtgcatgga cttacattta 162600
tttgtcaacg gtggaaacat atcttaatgt atatgaaaac taccacaagc cgggatttgg 162660
gtataaatca tttctacaga acagtagtat cgtcgacgaa aatgaggcta gcgattggtc 162720
cagctcgtcc attaaacgga gaaataatgg tactatcctt tatgatattt tactcacatc 162780
gctatcaatt ggggcgatta ttatcgtcat agtagggggt gtttgtattg ccatattaat 162840
taggcgtagg agacgacgtc gcacgcgggg gttattcgat gaatatccca aatatatgac 162900
gctaccagga aacgatctgg ggggcatgaa tgtaccgtat ggtaatgcat gctctggtaa 162960
ccaagttgaa tattatcaag aaaagtcgga taaaatgaaa agaatgggtt cgggttatac 163020
cgcttggcta aaaaatgata tgccgaaaat taggaaacgc ttagatttat accactgata 163080
tgtacatatt taaacttaat gggatatagt atatggacgt ctatatgacg agagtaaata 163140
aactgacact gcaaatgaag ctgatctata ttgtgcttta tattgggaca aaccactcgc 163200
acaagctcat tcaacacatc cactcttgga cagcttcatg ttaaaataaa ctgtaaatca 163260
ttcaatgata atgggagaag aatgtgagca aggatccatg gtgtctgctt tttatagtat 163320
ctaccgcaat gctacatata aaataaaaat atacctctac ccaaaaatgg gcggtatgag 163380
atgcacgggg aaaatacgca gctgttctca tatcccctga accgtactct ttttcccctc 163440
tccgccccgc ggaccccgag gcctcgtggg gcacctattt gcgcggagga aggcacggtt 163500
cccttttttt tttggggggg acccatctgc gtagagaaag gcacggttcc tctttttttt 163560
tcccctacaa catctcgttt gcatatgcaa gctctgggaa cttccctcta cctcaaagcg 163620
ccgtagggaa ctgaggcata ttcaatattc aatcctaggc cactcaatcc taggccactc 163680
gccaatataa gagggacttc cccccgccta tagagaggtt aacccaggag acacgctgtg 163740
gttagctcgt cgattcagta tttcctcttc gacagggccg cgcttttttg gtcgcggttt 163800
gtctgagact tgtacgaaaa gactagtccc atagcttcgt taacacttgc gatataaaaa 163860
aaaagagaac tcgttaggcc acaaatctat tttattggtt cgcgacaaga taacacactc 163920
cccctccccc tttcccctgt tcaagtcagg aaacccgtcg gaagattgat tctcaaatcc 163980
aattcggcga gcatgtaaga ccccggccaa tcgtacagaa ccccgagttt tgtttacttg 164040
cagatatgca ccgcccttcc ttgacgtggc aaacaaacta agctgtgttt atataaaacg 164100
gcaccccacc catatactcg tatacttgta cgatccagtg gtttttttat gtgggggagg 164160
gagaagaaca aattaaaaca ttgcacttgc ctgggctaca attccctttt ggctcgagct 164220
atgtcggaga gtcccggtgg acccgcggtt gtgctttggg ctgaaggaat tcgaaagtga 164280
ttgctgttcc cattgccctg ggacacatcc aaaatatcaa agtgtgtggt atgtatattc 164340
cttttttttt cctacgttct cttatacaat tctgaatttg cgggaggggg agaatatggt 164400
gcggtctggc tacgcgatta tcgagcaatg tttccccccc ttcgattttt tttttttact 164460
gtcgcctctt ggccagctca tgaaggatca gacatgcccg agtttttaat ttgtgatgaa 164520
taatactctc gatgttcagc aaaagtctga tttttctgaa aaccggatgg cgaacttgcc 164580
cgcaaaatgt atccggtatg gctcctcgat ttcgttctac attaaacagt ctactgttca 164640
tgtcggaggt ctgcgggcac aagttttacc gacctattcc ccctcccccc atattcatca 164700
acgggactca tgcactgcct ttcccggtgc tagctcgtag tatccataag cgcgcggtta 164760
atgtttgctg ctcgagtggt cgcattacct tttacacttc tttgaataaa gacccatccc 164820
tccgtttttt ttttttttga gcgcgttccc tgtcgagtct gcgatcttca aatccatctt 164880
ccctacatgg cgatttttga tgtgggaaca ctgggtgatt tgtgtttatt ttgtgggagc 164940
gtgaatattt gcccattagg tattaattaa aacaaaccgc agccgccgca taaagttgtc 165000
accgggaaat aatttgcggc tctagcgatg agtgtttaat ctgcttaacc ggcagtacag 165060
gaatgtttgc ctacagggct ttggtcggct gggccccaca atcgctcatc tacttcacaa 165120
ctctgctagt agatgataag agccttttgt gcttagtcga tggtattcaa gtatttgttt 165180
actgggcatg gccatctcaa actatgcaat cgttcagcag gacacaattt gactcggtgg 165240
gccggtctag tttgtgtgct agaaatgcaa tgctggcatt taaactattt gaagtacacc 165300
ggcgcgggta caaacctgat accgcacttt gcaattgggg gggggggggg gatcgagaac 165360
attagccgcg acatccatct cgggcagcaa tcagatacgt ataacaatgc tgtggagcgg 165420
gcctggtatt ggagcatggc ctaaatacaa aaccagatgc tagctgttcg ggattatatc 165480
cgcagctgac acctacattt atgtttcgac tttcagcaca tcgaaatttc cgcacttgaa 165540
ccgtagcttc cctcccccca catcttgtgg tctagcatgg gagggccatt tccacgagac 165600
ccccaaaggg agtcatagac agctacgcct tccgtattcc cctcacatcg gcccacccac 165660
catctatttg cgcccctcct aaaccctaaa aatggacaac ccgcctgatt tcgacagctt 165720
gttggcagct tttgacgaag acgtggggat ttttccacat acgccagcca ctccggggga 165780
cccttatcaa ggcgtctcgc tgcaaacacc ctgtgtcccc gtaccatcgc tagccggaca 165840
atcgggtaca taccgccccc actccagtta ccatggacag cgctcgcttt ccagcggccc 165900
cgtccccgct gcccatagcc cacgctccgg tcggcctgga cagcactcga cgtccaacgg 165960
cgttgccgcc gctgcccctc ccgcagccac ccgagcagtc tgcgataccg cgggccccac 166020
caccgatact tccagcaatc gccccggcgg tcgtaactcc tcaaacggcg cagatgaatc 166080
tggtgagagt tccagtgacc gttccccttc ttatagcccc tgcgatagct actgcgaccc 166140
cgatcgcgtt agttcctatc gttcatctgt tgacggttcc cccgaatccg gggacatcga 166200
gtccgcttcc ggaagcggcg ggacatccag tcctcctcta ctggagatcc tggcagccga 166260
ttttggtgag gacaccaagg cgctagatcc cgattactat ctgagagccg atcccaggtt 166320
caaggcttat ttctatggaa tggatgaaat aagccccact acttcagagg acatagatga 166380
actcctagtt ttgttgagtc cccagtcggt caatagggcc tcggagaggc aattggcaga 166440
tacggcggcg agcgccttga gggcaccctc tcccgttttc tggtcagctt tcgatagtcg 166500
atacccgcat ttagctcccg cgaaccagtc aaactctgat ccactctgcc cggaaacgtc 166560
cactgcttct gcccaaatct tgcacacaaa ttcgcctacc ccccctactt ccacctcacc 166620
tgctcccatt ccatctccca ctcagccccc agcatgcctt ccctcacctg cccccatttc 166680
ctctcccgtc cagcccccag cgctcctccc cttgatattt tctccaataa ctccggtcga 166740
atttatacag ccccaatccc ccccgagccc tccccaggct ccgtctccgc ctgcgcattc 166800
ctccagttct tgttccccct cgcaccttgc accttctccc ctctcctctt ctcccctctc 166860
ttctcctcca caattgtccc ccgcccccgt atcaccccca tcgtccccac ctcctttgtc 166920
tcccggagaa cttgctccaa gcccggaccc ccctcgtcat tctatctcat cccagccaca 166980
gagttgtccc gtccctagtt taggtcggag cgcagatttc agacgggaag ttgcagcccc 167040
ccgagtacgg ggggccggct ttcggtatgt gtatcgcctg tcaacttccg ttgcaatccc 167100
atctcccccc agagaagaag tcgaactgat aaaacatttg cctggtagtt atgctaaatt 167160
gtggctccat gatcccgatg gattcagccc cttgcccgag gaactaaaac gggcagggag 167220
acaaaacatg agaagctttc tcctaacact gccagatacc caccgctgct ctgcctactg 167280
ggatcgtttg gcaacggaag ctttattaag ggagattcta cccccacccc atactagctc 167340
cccccagaaa tgtccccgga taatcgaact gccgagggaa ccccctctgc ttgacggcga 167400
ttataaaccg tttgattggg atgtggagtg caattatgca cctccccttc cagacttccc 167460
agaacctata tgtgaactat cgaaggactg ggtgggctgt aaaatctggt tgttctcacg 167520
ctgttcccga ctcgtgcttt ctgtgctcga tgatgcactg cattccgaga gtcatgagaa 167580
cgtcctgggg tctcgtggct gtggttgggg ccctagaagc gaatgcccgg tacctccccc 167640
gggtatggta actctcccat catgtgtgtg ggaagcagct gcgcggctcc ctactcccgc 167700
cctccaaatt cccaagtatg catatattat atcagctttt cttcgatttc tggggcttcg 167760
tgttaccccc gaatttgtgt ttaaggttcc acgcctttcc taccgtttgt tggaccggct 167820
ccgttgtctt agacgtgtcc agtatatggc gtacatcctt acacaagatt tttcatatca 167880
gctgcaagca gctcagggcc tgccgtgttt tccggcatgt gcacccccac caggtgcagg 167940
cactcctctg gatgaggatt ggtatgggat tcccgctact aggtgtccta ctattcccga 168000
ccgccttagg cattgcggcc aattctactc cgacaattat tgccccgtac tcaccgagat 168060
tacctgggtg gacggccgag atggaagcac caatccctgg accggtttgg catggaaaga 168120
ctttaaatgc ctgcattaca gatacctttt ttataatgta cgtaaggggt ttgtgatggc 168180
cctcgagaat taccttacag aaaactctgt aatacctggc tgcgaagtta cttttgagat 168240
gccacaacca tctaccacgc tgcctcctgc gctctccgcg gccattcgcg aagctagagt 168300
tgagcttagg aatagaaata atatacagac tggagatgga agcgagtctg gagaacgccg 168360
ggactccaaa gtttcctatg cctttatggt ccaacaactc gctatcgcga tggtcgagtt 168420
ggggttcccg gcgtacggtc ccgccatcga aaagcgagtc cggcccctat acaaagcttt 168480
atgcgactgg cgtgctgccg taacattagc agcccgacgg cggttccagc agctccgttg 168540
caacgccaat atggacgatg acgggcagcc catgttcccc cctcttcccg ttccagattg 168600
gaataatccg tccacagact ggcgcccaag tccccctcgt tctgggccaa agaaagattt 168660
ctgtggagac ttacctgcac cactcacctc aggtccacgg ctgactactc catcttctgg 168720
cagaatgagc gaactgcctc acacaacctc atctccacga agttccccca gaccacgcgg 168780
ccctgagact tcaccgtcaa atgagcacat tattatatcc cctccccgga atcccccatc 168840
caatactact caccggaacg tcggacatgt ttccagatcg ccatcctctt catcttcctc 168900
ctcttcatca tcctcaccgt catcatcttc tctaatcgtc ctgtcctcac cttcatcatc 168960
taggtcacca tctccgtcgc cccccagacc gcgggctgat tcttcgagcc gcccgcgtcg 169020
gggcagaggt agtaatcgtg gtgggcgatc cggaccgcag tctaagggga gaaaagcatc 169080
gccccgaacg cgcaaactgg aagatgagga ctacttaccc caagaaaccg caaacaggcg 169140
tggaggagga cgcccacgtg ggcgtcctcc caagtccggc cgagccgtcc aacgcaatga 169200
tattcaggtg acatcctcct ctggccttgc ggacacgtcc ccctatgacc tctgcggaag 169260
cgtatggtgg gaggttccgt tgccaccgcc tggccggtgc tggttcggtg gccttggtgg 169320
gcatcgacaa gcacttacgg atagtccaga gatagtagaa gctatccaca gattcaacac 169380
atcccatggc ccagttcccg tctatgtaga ggaaatgaaa gattatgcca aacaatacga 169440
cgctctcgta aactctttgt ttcacaaaag catgaaagta aatcctctga actggatgca 169500
ccacgggaag ctgtctcccg ccgatgctgc cctaaaccac atatatgttc agaaattcca 169560
gagttcatac gattcgcccg gagcggctgt aactggcaca gttaacagat gcatccctca 169620
catagctggt gccatgaaag agagaaaatt attatgggcg tttccgcata tagccgcgag 169680
tatagctatg acacgcaggt attgcaaaga ccaaaaaacc tttctgttcc gttcccttaa 169740
gaaagcatat gcatcaatgg cttttccaga taactcttcc gaaacggaaa agggaatctc 169800
atctaaaccc tcaacgtcgc catcggtttt gataaccaca tctacccaaa caaccgcacc 169860
cccacatgcc cctaaaattg atgtgacggc aatccatgga cgcgtatacc aaagtgttgt 169920
ggacttgagt aggtgtctgg cggacggatc tcttgatgac cccgaattta gttttgcggg 169980
atgcacacgt cccgactgcc ttgtcgaaga attcgacgca gccagaccct tggaagaact 170040
cgcagatgct tgtgttttgg cctgcgatag tgtagtggcc gcgctcctat gtggtccaga 170100
cgggccgcat agagtagcta aaatgttatc tttttacgac tcgcgtatta caccgcacgt 170160
tcccgatttg caacaatggg agaaatgccg tattctcctc gtctcctggt accatgaatt 170220
atcggatctc agagcagctg tttatggcgc gtatggaaac acgcctacct ctcaacatct 170280
cgatgagcgt gctcttgcag ctcgcgtggt atcactgatt gcagaaacta tcggaccttt 170340
ggttagacaa gacccagatc gagcgtgggt gcgcatgggg tcaagggaca ttacttctct 170400
cttactacga gactggcgcg gaacggacga tggtgatcct ggccttgtaa aggccaagca 170460
cctgcgccgc acagcggagt tgcttaacga tgggcggagt tcaaagggca cttatggggt 170520
atttgctcca ccacggagac ccgatcagct gtttcgaggt cctgggcgtc cccgacgctc 170580
cacttcatca tcccagtctg cgtctgataa atctcccatt aaatccaccc accgacatac 170640
aagcgatcca ataccgataa gcaccccaag acccgaaagg gaccctgccg gaacgccaca 170700
cgagaacaca atgtccggcc cagtacagcc tgcggcaaat gggcacagtt gcagctctac 170760
tccaaccccg gctaaaaaag ggaataaaac ttctagtgat actatttcgc taaaagatcc 170820
gacaaagact cggattaaag cctcggctaa agcacagacg gatgagacat tgccagaaac 170880
tagcaccgcc catccctcgg ctatggacca atcatcctct ctggaacgaa agaacttata 170940
cactggaccc gccgtttcta gcaaggagcg acgcagatct gcccagtcta gtaccccttc 171000
tgatattggt ggagtttccc gtaagcgcaa gtcagctccc gagcaataca aacagggttt 171060
gcagacacca ctcccaatgc cggaaccgtc ggtcggacaa acactgcttg accctaccac 171120
cacaacccac gatattctat caagttccct tccaaaccgc tcttgcagta gcagcccgtc 171180
cccatccaaa cgcccatacc acccgtcctg ctatagtcct accgatatta tgaccggggc 171240
cttagtaggc ccacggggac gtcaggaccg tgccgcattc aggcaattcc cggttggaac 171300
ggtgatcggt caaacccctc cccaatctgt tctgaacgca tactgcccca acggggcatt 171360
tgtggaacta gtagagtttg ccagaatccc cgaaccatgg caagaggtgt tgcgctattc 171420
tcccgaggct atggcagaca tcgctcgtgt cgcaaatgcg ttacctggaa aatataatag 171480
taacgaaatt ataactagcg ctgcatctga ggcatttcac acagccactt caatgcttag 171540
agcaaggact gcttggatgc gataccaaca agaatctccc gatgatgtgt ctatcgttgt 171600
tttatactca cccctcccag gcgaacacct gttttgcgta cccgctccag atactccccc 171660
gggagggccg aagtttgata ataagcgagg aggattatca ttcctccttg ctgcattttc 171720
taaccgatta tgcttacccg agagcagtgc gtgggctggc cgatggaaag cagcacccga 171780
tatatctcca ctgactcgga tgggagtcct gtttttatca acagaggatt tgggctatca 171840
gggtgctgtg gaatacctac aacgtcaatg tatgaaacgt aaaaagaaac ttataatcat 171900
ggatacggta gaagatcgat atagactacc aaacggtcca tgtatcattg aagaagcgac 171960
acgttacatg aaatgtataa tttcaccccg tagtcagtgc tgtgtccgct ggcccggcct 172020
tcgcgatttc gggaccacta ttataacctc gcgggatgtt gtcggcccat taactctcac 172080
ggatctagaa cagtattatt actgtgaaat tgggatagag gacagtacca tcaatctatg 172140
ttgtaccggc aatgtccggt atacagtcga aacgcgcctg gaagacgtat cttgcgttcc 172200
tactactccc ctcttttatt ttactgcagt taaacacgtg aggccagact ttctctgcgg 172260
cgagacatat tctaaccgag ctgcacgaaa atggggttta tgtgcccccc tgagacccat 172320
atatgtgatt gaatctaaaa tgaatgcgat cgtttccccc tctttcttac atccgacggc 172380
tcgtaatctt tgtcggtctg taatattacc tccagatcca gaggccaggc cggttgttgt 172440
tcacattccc gagggaacat gttccgctct agcagaagat atggtagcct caattcgaag 172500
cagttgtatt acctggggac agcatgagga aggtggtccg gaaaccacag cccaggaaaa 172560
ttcggacatt cgggcaatga aagttcgacc ccccactaaa cctccataca tgtctccatt 172620
aaacataggg aatcgggaca cgacctttac agactagtca ataaatattg tccccaaacc 172680
tcataacaat ttagacaagt gtcgaactag tatgaatcac tcaattcgcc ctccaatctg 172740
tatatatagt acttccttta cattgtcctg tacacatcca tcccatgtac atttccctcc 172800
attttagtca tagcatttca ctgagatcat cacatttgta tattgtgtac atgctatgag 172860
gtgtaaaaac cttagaagtt ggtgaatatg tgttgtcaaa ttcgaatttg tcaagaatgg 172920
ctaaagggat gataaattaa agggtgagca caaaaaattt tcattactag gacggaagcg 172980
atactactgc tgaaactctg tacaccgtcc cctatgtcgg gaatatccct tactcctgta 173040
aaacaggaga atgaaccatg ttcgttttta cgccacgaca gcgggtcaac acaggccgtt 173100
aatgacactt acgttgaccg agctcgcccg tcggcagacg caagagaaca ttgcgctgca 173160
tcagatccag aagaatggca ctcgggggac aggccaccgc gtctatgtcg gaagcctagc 173220
cggttttaca ggcgcattgt aattcctgag actgctccgg tgctttcgcc acgctacgat 173280
ctatcggacg aaccacatgc acctggaacg acaatgatct ccggaccgag aacacagtga 173340
taaaaaaaag aacatagttg tgacttgtct aaataaaaaa gatagttata taagccgtta 173400
tatagttatc ttggtacttg ttcgaatgtt acgtatattg ttaccttgtt aagcgttttt 173460
aataaagaaa aggggcgcat atacagtcta tcaattcgta gatttcttca aagcaagtta 173520
gttcgtttag aatgtaacca ttgttacagg gaaaggaaac agatcaacat ggcaaaacga 173580
tgtggctcca attaaagtat taaggagggg atgtacagga atataagata aatggtgcct 173640
aggaaccgcc ccgcaccaag gcacaatcgc aatgtacatg aatgactagc agtgtgtaag 173700
ggcggtgatg agggcacgtt tacttcctaa gtcatcgctc tttagttggg aggaaagttt 173760
cctagacaaa ctgttatctc gtagagattt cgagttgcca acaggagaga tcgggacctc 173820
tacgagacaa cgccatccac taggaagctt ctacgattaa gcagttctga ggacacattt 173880
cccccaaaaa ctgtaatctc gtagagatct cgagttgctg gtaggagaga tcgagatctc 173940
cccgagataa cagttctcct tggagcgttc gcggctctct tggctagaga gcatcatcac 174000
atcgagttct tcctatgagg cttccattcc atgtcgcgac aatcaggacg atgtaattcc 174060
cagagaaaac tgtcatttcg cagggatctc gagttagtgt cacgagaaca ctacggaaca 174120
acagattttc ccaggacgtt tccatgcttc ggcagtcgaa accgggaaat ctcctggaaa 174180
actattgttc cgtagaggtc acgcagtacg agaacgatag atcgaaacca accacagaac 174240
aataggtttc cgtaggaata tgccacgaaa actcgatcgc gtatcacaac gtttattccg 174300
aactcctgtc actggatatg tggatcggga atcgaggaat gtcgtccaat taaagaagat 174360
catgcaggga taatagcgtg ttggccaaat ggcgggaact ttgaaattgg tatggcgcga 174420
ttttgaaaac ggcgcggaaa aaggcgccaa acaatggcgc gcaatttttt ggcgcctttt 174480
tgttggcgcg cattttttgg cgccaacacc acgattctta taggctggga accgcgtaac 174540
atataactcc gcaatgcctg actcaaatct attaacaggc tatcatctat tcaacgagga 174600
caagtattaa aaattcaaac cgtaaaataa caagtttaaa atcgtagtaa gcacacagaa 174660
acccatagat ccccgacgca gtgcaaaggt cagtgtaacg cctacataat gagtgaaatg 174720
aagcggggca tacaagccta taaattaaca aacacgtttg tatagggaga aggaaacaca 174780
gaacaaatta ataaaacaaa aacaaaacac ttaccctctc aactagtccg agagacctgc 174840
ggtaatcgga atcgagttcc aaaaacggat gctggagctg ccgccaaact tgtgccaaac 174900
gcacgggtag cggaaggaaa tcaggaacgc gccctctaca tgaccgcgca tgcgcggggc 174960
cgaaaatagg aaaactacga ctgcgcacgc gccctctaca tgaccgcgca tgcgcggggc 175020
cgaaaatagg aaaactacga ctgcgcacgc gccctctaca tgaccgcgca tgcgcggggc 175080
cgaaaatagg aaaactacga ctgcgcacgc gccctctaca tgaccgcgca tgcgcggggc 175140
cgaaaatagg aaaactacga ctgcgcacgc gccctctaca tgaccgcgca tgcgcggggc 175200
cgaaaatagg aaaactacga ctgcgcacgc gccctctaca tgaccgcgca tgcgcggggc 175260
cgaaaatagg aaaactacga ctgcgcacgc gccccctaca tgaccgcgca tgcgcggggc 175320
cgaaaatagg aaaactacga ctgcgcacgc gccctctaac cctctcgcgg ccacacactg 175380
tataaaaaaa aaaatttcgt cgaaccccta gcggccaacc gatccctaac cctagacctg 175440
aaccctaacc ctaggcctga accctaaccc taaccctaac cctaacccta accctaaccc 175500
taaccctaac cctaacccta accctaaccc taaccctaac cctaacccta accctaaccc 175560
taaccctaac cctaacccta accctaaccc taaccctaac cctaacccca accctaaccc 175620
taaccctaac cctaacccta accctaaccc taaccctaac cctaacccta accctaaccc 175680
taaccctaac cctaacccta 175700
<210> 2
<211> 18
<212> DNA
<213> 人工序列()
<400> 2
atgtctcagg agccagag 18
<210> 3
<211> 16
<212> DNA
<213> 人工序列()
<400> 3
tcagggtctc ccgtca 16
<210> 4
<211> 25
<212> DNA
<213> 人工序列()
<400> 4
caccgtcgac ccgagagaaa gatcg 25
<210> 5
<211> 25
<212> DNA
<213> 人工序列()
<400> 5
aaaccgatct ttctctcggg tcgac 25
<210> 6
<211> 24
<212> DNA
<213> 人工序列()
<400> 6
caccgtactc agtctacggt ctgg 24
<210> 7
<211> 24
<212> DNA
<213> 人工序列()
<400> 7
aaacccagac cgtagactga gtac 24
<210> 8
<211> 24
<212> DNA
<213> 人工序列()
<400> 8
cacctcttcc gagtctaagc taca 24
<210> 9
<211> 24
<212> DNA
<213> 人工序列()
<400> 9
aaactgtagc ttagactcgg aaga 24
<210> 10
<211> 24
<212> DNA
<213> 人工序列()
<400> 10
caccgatatg gacatcgcac atta 24
<210> 11
<211> 24
<212> DNA
<213> 人工序列()
<400> 11
aaactaatgt gcgatgtcca tatc 24
<210> 12
<211> 22
<212> DNA
<213> 人工序列()
<400> 12
tccgcattgt gactctcagc ag 22
<210> 13
<211> 22
<212> DNA
<213> 人工序列()
<400> 13
acatcgtaga gaaagcataa gg 22

Claims (8)

1.一株马立克病病毒特超强毒株，其特征在于，所述马立克病病毒特超强毒株为马立克病病毒HN302，已保藏于中国微生物菌种保藏管理委员会普通微生物中心，保藏编号为CGMCC NO.21929。
2.利用权利要求1所述的马立克病病毒特超强毒株HN302构建的MDV基因缺失毒株。
3.如权利要求2所述的MDV基因缺失毒株，其特征在于，所述MDV基因缺失毒株是以马立克病病毒HN302为亲本毒株，构建的MDV单基因或多基因缺失疫苗候选毒株HN302ΔmeqΔM11、HN302ΔmeqΔLAT和 HN302ΔmeqΔM11ΔLAT。
4.如权利要求2所述的MDV基因缺失毒株，其特征在于，构建MDV基因缺失毒株的方法，是利用CRISPR/Cas9基因编辑技术、细菌人工染色体BAC技术或基因同源重组技术；所述缺失基因是MDV蛋白编码基因或非编码RNA基因。
5.如权利要求4所述的MDV基因缺失毒株，其特征在于，所述缺失基因是meq基因缺失、miR-M11基因缺失或LAT-miRs基因缺失。
6.如权利要求1所述的马立克病病毒特超强毒株HN302在制备MDV疫苗中的应用。
7.如权利要求2所述的MDV基因缺失毒株在制备MDV疫苗中的应用。
8.如权利要求6或7所述的应用，其特征在于，所述MDV疫苗为鸡马立克病MD基因工程疫苗、鸡马立克病MD多联疫苗、鸡马立克病MD多价疫苗或鸡马立克病MD传代致弱疫苗；所述鸡马立克病MD基因工程疫苗为基因缺失、基因重组或载体疫苗；所述权利要求6的应用是利用所述马立克病病毒特超强毒株的病毒粒子或病毒核酸DNA。
CN202210261757.0A 2022-03-16 2022-03-16 一株马立克病病毒特超强毒株及其基因缺失毒株的构建和应用 Active CN114717200B (zh)

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