KR101787453B1 - 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법 - Google Patents

보관 안정성이 향상된 약학 조성물 및 그의 제조 방법 Download PDF

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KR101787453B1
KR101787453B1 KR1020160095415A KR20160095415A KR101787453B1 KR 101787453 B1 KR101787453 B1 KR 101787453B1 KR 1020160095415 A KR1020160095415 A KR 1020160095415A KR 20160095415 A KR20160095415 A KR 20160095415A KR 101787453 B1 KR101787453 B1 KR 101787453B1
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KR
South Korea
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weight
formula
composition
paclitaxel
drug
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KR1020160095415A
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English (en)
Korean (ko)
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KR20170015200A (ko
Inventor
김봉오
경규진
김지영
김혜림
민범찬
윤유정
서민효
이일웅
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주식회사 삼양바이오팜
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020160095415A 2015-07-28 2016-07-27 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법 KR101787453B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20150106629 2015-07-28
KR1020150106629 2015-07-28

Publications (2)

Publication Number Publication Date
KR20170015200A KR20170015200A (ko) 2017-02-08
KR101787453B1 true KR101787453B1 (ko) 2017-10-19

Family

ID=57884713

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020160095415A KR101787453B1 (ko) 2015-07-28 2016-07-27 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법

Country Status (13)

Country Link
EP (1) EP3328437A4 (ja)
JP (1) JP2018521105A (ja)
KR (1) KR101787453B1 (ja)
CN (1) CN107466231A (ja)
AU (1) AU2016299548A1 (ja)
BR (1) BR112018001737A2 (ja)
CA (1) CA2993928A1 (ja)
HK (1) HK1249441A1 (ja)
IL (1) IL257187A (ja)
MX (1) MX2018001223A (ja)
RU (1) RU2018107055A (ja)
WO (1) WO2017018820A1 (ja)
ZA (1) ZA201801187B (ja)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999045001A1 (en) 1998-03-02 1999-09-10 Bristol-Myers Squibb Company Synthesis of paclitaxel baccatin iii by protecting the 7-hydroxyl using a strong base and an electrophile
WO2005037840A1 (en) 2003-10-16 2005-04-28 Mayne Pharma (Usa), Inc. Method for inverting the c2’ hydroxyl group of taxane esters

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1233420C (zh) * 2000-05-12 2005-12-28 株式会社三养社 通过嵌段共聚物的相分离制备聚合物胶束的方法
US7217770B2 (en) * 2000-05-17 2007-05-15 Samyang Corporation Stable polymeric micelle-type drug composition and method for the preparation thereof
CN1303155C (zh) * 2001-10-18 2007-03-07 株式会社三养社 具有改进稳定性的聚合物胶束组合物
US9801818B2 (en) * 2007-12-31 2017-10-31 Samyang Biopharmaceuticals Corporation Method for stabilizing amphiphilic block copolymer micelle composition containing poorly water-soluble drug
KR101024742B1 (ko) * 2007-12-31 2011-03-24 주식회사 삼양사 탁산 함유 양친성 블록 공중합체 미셀 조성물 및 그 제조방법
US8853351B2 (en) * 2007-12-31 2014-10-07 Samyang Biopharmaceuticals Corporation Highly pure amphiphilic copolymer comprising hydrophobic block from alpha-hydroxy acid and process for the preparation thereof
EP2201935B1 (en) * 2008-12-26 2020-07-08 Samyang Biopharmaceuticals Corporation Polymeric micelle composition containing a poorly soluble drug and preparation method of the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999045001A1 (en) 1998-03-02 1999-09-10 Bristol-Myers Squibb Company Synthesis of paclitaxel baccatin iii by protecting the 7-hydroxyl using a strong base and an electrophile
WO2005037840A1 (en) 2003-10-16 2005-04-28 Mayne Pharma (Usa), Inc. Method for inverting the c2’ hydroxyl group of taxane esters

Also Published As

Publication number Publication date
BR112018001737A2 (pt) 2018-09-11
WO2017018820A1 (en) 2017-02-02
RU2018107055A3 (ja) 2019-08-28
AU2016299548A1 (en) 2018-02-22
RU2018107055A (ru) 2019-08-28
MX2018001223A (es) 2018-11-09
JP2018521105A (ja) 2018-08-02
CA2993928A1 (en) 2017-02-02
ZA201801187B (en) 2018-12-19
KR20170015200A (ko) 2017-02-08
EP3328437A1 (en) 2018-06-06
IL257187A (en) 2018-03-29
CN107466231A (zh) 2017-12-12
HK1249441A1 (zh) 2018-11-02
EP3328437A4 (en) 2019-03-20

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