KR101738937B1 - 개과 동물의 호흡기 질병 조절을 위한 물질 및 방법들 - Google Patents
개과 동물의 호흡기 질병 조절을 위한 물질 및 방법들 Download PDFInfo
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- KR101738937B1 KR101738937B1 KR1020147017285A KR20147017285A KR101738937B1 KR 101738937 B1 KR101738937 B1 KR 101738937B1 KR 1020147017285 A KR1020147017285 A KR 1020147017285A KR 20147017285 A KR20147017285 A KR 20147017285A KR 101738937 B1 KR101738937 B1 KR 101738937B1
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| GB0613977D0 (en) | 2006-02-07 | 2006-08-23 | Peptcell Ltd | Peptide sequences and compositions |
| US7682619B2 (en) | 2006-04-06 | 2010-03-23 | Cornell Research Foundation, Inc. | Canine influenza virus |
| WO2008070332A2 (en) * | 2006-10-25 | 2008-06-12 | Intervet International B.V. | Feline influenza vaccine and method of use |
| CN101838708B (zh) * | 2010-03-30 | 2012-07-18 | 华南农业大学 | 一种检测犬流感的方法 |
| EP2953967B1 (en) * | 2013-02-07 | 2019-05-01 | Massachusetts Institute of Technology | Human adaptation of h5 influenza |
| CN103881983B (zh) * | 2014-03-07 | 2016-08-31 | 中国农业科学院哈尔滨兽医研究所 | 重组犬流感病毒毒株、其制备方法及由其制备得到的疫苗 |
| WO2017004453A1 (en) * | 2015-07-02 | 2017-01-05 | Indevr, Inc. | Universal priming mixture for amplification of influenza viral gene segments for diagnostic applications |
| EP3980445A1 (en) * | 2019-06-07 | 2022-04-13 | Intervet International B.V. | Mdbk irf3/irf7 knock out mutant cell and its use for vaccine production |
| CN110592276A (zh) * | 2019-07-08 | 2019-12-20 | 北京世纪元亨动物防疫技术有限公司 | 用于检测犬流感病毒的特异性引物及试剂盒 |
| CN115074461B (zh) * | 2021-03-11 | 2023-08-25 | 上海市农业科学院 | 犬流感病毒、犬冠状病毒和犬呼肠孤病毒的三重pcr检测方法 |
| CN115725517B (zh) * | 2022-09-01 | 2026-01-02 | 军事科学院军事医学研究院军事兽医研究所 | 一种h3n2犬流感重组病毒株及其应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001060849A2 (en) * | 2000-02-16 | 2001-08-23 | The University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Cold-adapted equine influenza viruses |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5034322A (en) | 1983-01-17 | 1991-07-23 | Monsanto Company | Chimeric genes suitable for expression in plant cells |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US5106739A (en) | 1989-04-18 | 1992-04-21 | Calgene, Inc. | CaMv 355 enhanced mannopine synthase promoter and method for using same |
| US6309647B1 (en) * | 1999-07-15 | 2001-10-30 | Aventis Pasteur | Poxvirus—canine dispemper virus (CDV) or measles virus recombinants and compositions and methods employing the recombinants |
| US5756102A (en) * | 1990-11-20 | 1998-05-26 | Virogenetics Corporation | Poxvirus-canine distemper virus (CDV) recombinants and compositions and methods employing the recombinants |
| US5994056A (en) | 1991-05-02 | 1999-11-30 | Roche Molecular Systems, Inc. | Homogeneous methods for nucleic acid amplification and detection |
| US5612487A (en) | 1991-08-26 | 1997-03-18 | Edible Vaccines, Inc. | Anti-viral vaccines expressed in plants |
| US5484719A (en) | 1991-08-26 | 1996-01-16 | Edible Vaccines, Inc. | Vaccines produced and administered through edible plants |
| UA48104C2 (uk) | 1991-10-04 | 2002-08-15 | Новартіс Аг | Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника |
| RU2193065C2 (ru) * | 1994-03-14 | 2002-11-20 | Мерк энд Ко. Инк. | Конструкция днк (варианты), днк-вектор, иммуногенная композиция против вируса гриппа, способ индукции иммунного ответа, вакцина и способ вакцинации |
| JP3745370B2 (ja) * | 1994-03-30 | 2006-02-15 | ヴァイロジェネティクス コーポレイション | イヌヘルペスウイルスｇＢ、ｇＣおよびｇＤの、核酸およびアミノ酸配列とその利用 |
| GB9524395D0 (en) | 1995-11-29 | 1996-01-31 | Nickerson Biocem Ltd | Promoters |
| US6252139B1 (en) | 1996-07-18 | 2001-06-26 | The Salk Institute For Biological Studies | Method of increasing growth and yield in plants |
| US6063385A (en) | 1997-11-07 | 2000-05-16 | Wisconsin Alumni Research Foundation | DNA vaccine for parvovirus |
| US6472375B1 (en) | 1998-04-16 | 2002-10-29 | John Wayne Cancer Institute | DNA vaccine and methods for its use |
| US6177082B1 (en) * | 1998-08-13 | 2001-01-23 | The University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Cold-adapted equine influenza viruses |
| US6579528B1 (en) * | 1998-08-13 | 2003-06-17 | The University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Cold-adapted equine influenza viruses |
| EP1133556B1 (en) | 1998-11-24 | 2006-02-08 | Pioneer Hi-Bred International, Inc. | Root-preferred promoters and their use |
| JP2000230931A (ja) * | 1998-12-07 | 2000-08-22 | Katakura Industries Co Ltd | 家畜インフルエンザウイルスに対する抗体の検出方法およびこれに用いるキット |
| DE19960843A1 (de) | 1999-12-16 | 2001-06-28 | Florian Grundler | Wurzelspezifischer Promotor |
| HU229101B1 (en) * | 2000-04-28 | 2013-07-29 | St Jude Childrens Res Hospital | Dna transfection system for the generation of infectious influenza virus |
| BR0111819A (pt) * | 2000-06-23 | 2004-01-06 | American Cyanamid Co | Moléculas de ácido nucléico isoladas, e, seq ência de aminoácido isolada |
| US6455760B1 (en) | 2000-11-16 | 2002-09-24 | The Salk Institute Of Biological Studies | Expression of flavin-containing monoxygenases in plants |
| US20040067506A1 (en) | 2000-12-04 | 2004-04-08 | Ben Scheres | Novel root specific promoter driving the expression of a novel lrr receptor-like kinase |
| EP1494708A1 (en) * | 2002-04-12 | 2005-01-12 | Capua, Ilaria | Purified subfragment codifying for neuroaminidase, recombinant neuroaminidase and its use in zooprophylaxis |
| US7285656B2 (en) | 2002-04-26 | 2007-10-23 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Natural Resources Canada, Canadian Forest Service | Root-specific conifer gene promoter and its use |
| WO2004029213A2 (en) * | 2002-09-28 | 2004-04-08 | Massachusetts Institute Of Technology | Compositions and methods for delivery of short interfering rna and short hairpin rna |
| WO2004057021A2 (en) * | 2002-12-19 | 2004-07-08 | UNIVERSITé LAVAL | Molecular methods and compositions for detecting and quantifying respiratory viruses |
| US20040123349A1 (en) | 2002-12-20 | 2004-06-24 | Qi Xie | SINAT5, an Arabidopsis thaliana gene promotes ubiquitin related degradation |
| CA2523676A1 (en) * | 2003-05-15 | 2005-02-17 | The Board Of Regents For Oklahoma State University | Dna vaccine expressing ha1 of equine-2 influenza virus |
| CN1458168A (zh) * | 2003-06-02 | 2003-11-26 | 中国农业科学院哈尔滨兽医研究所 | 重组猪流感病毒np抗原、其制备方法及在诊断中的应用 |
| US8592197B2 (en) | 2003-07-11 | 2013-11-26 | Novavax, Inc. | Functional influenza virus-like particles (VLPs) |
| CN101253267A (zh) * | 2005-04-21 | 2008-08-27 | 佛罗里达大学研究基金公司 | 用于犬科动物中呼吸系统疾病控制的物质和方法 |
| NZ566490A (en) * | 2005-10-07 | 2011-06-30 | Pfizer Prod Inc | Live attenuated or killed H3N8 influenza vaccines and methods to treat canine influenza |
| US7468187B2 (en) * | 2005-10-18 | 2008-12-23 | Iowa State University Research Foundation, Inc. | Canine influenza virus and related compositions and methods of use |
| AU2006304747B2 (en) * | 2005-10-19 | 2013-10-03 | Cornell Research Foundation, Inc. | Influenza viruses able to infect canids, uses thereof |
| WO2007047728A2 (en) * | 2005-10-20 | 2007-04-26 | Wyeth | Compositions and methods for the treatment of canine influenza virus disease |
| US7682619B2 (en) * | 2006-04-06 | 2010-03-23 | Cornell Research Foundation, Inc. | Canine influenza virus |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001060849A2 (en) * | 2000-02-16 | 2001-08-23 | The University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Cold-adapted equine influenza viruses |
Non-Patent Citations (1)
| Title |
|---|
| The detectives, CORNELL VETERINARY MEDICINE NEWSLETTER, 2014.12.31.* |
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