KR101730216B1 - Cd36 발현성 결합조직초 세포를 함유하는 모포를 재생하기 위한 조성물 - Google Patents

Cd36 발현성 결합조직초 세포를 함유하는 모포를 재생하기 위한 조성물 Download PDF

Info

Publication number
KR101730216B1
KR101730216B1 KR1020137007049A KR20137007049A KR101730216B1 KR 101730216 B1 KR101730216 B1 KR 101730216B1 KR 1020137007049 A KR1020137007049 A KR 1020137007049A KR 20137007049 A KR20137007049 A KR 20137007049A KR 101730216 B1 KR101730216 B1 KR 101730216B1
Authority
KR
South Korea
Prior art keywords
cells
animal
blanket
human
dsc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020137007049A
Other languages
English (en)
Korean (ko)
Other versions
KR20130112872A (ko
Inventor
유조 요시다
츠토무 소마
시게요시 후지와라
Original Assignee
가부시키가이샤 시세이도
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 가부시키가이샤 시세이도 filed Critical 가부시키가이샤 시세이도
Publication of KR20130112872A publication Critical patent/KR20130112872A/ko
Application granted granted Critical
Publication of KR101730216B1 publication Critical patent/KR101730216B1/ko
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0271Chimeric vertebrates, e.g. comprising exogenous cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • A61K8/985Skin or skin outgrowth, e.g. hair, nails
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3813Epithelial cells, e.g. keratinocytes, urothelial cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00Preparations for affecting hair growth
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0625Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0627Hair cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0625Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0627Hair cells
    • C12N5/0628Hair stem cells; Hair progenitors
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00Modified animals
    • A01K2207/12Animals modified by administration of exogenous cells
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/70Biological properties of the composition as a whole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/18Materials or treatment for tissue regeneration for hair reconstruction
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0666Mesenchymal stem cells from hair follicles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Environmental Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Botany (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Birds (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020137007049A 2010-09-29 2010-09-29 Cd36 발현성 결합조직초 세포를 함유하는 모포를 재생하기 위한 조성물 Expired - Fee Related KR101730216B1 (ko)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2010/066999 WO2012042618A1 (ja) 2010-09-29 2010-09-29 Cd36発現性結合組織鞘細胞を含有する毛包を再生するための組成物

Publications (2)

Publication Number Publication Date
KR20130112872A KR20130112872A (ko) 2013-10-14
KR101730216B1 true KR101730216B1 (ko) 2017-04-25

Family

ID=45892122

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020137007049A Expired - Fee Related KR101730216B1 (ko) 2010-09-29 2010-09-29 Cd36 발현성 결합조직초 세포를 함유하는 모포를 재생하기 위한 조성물

Country Status (7)

Country Link
US (2) US20130212724A1 (https=)
EP (1) EP2623106B1 (https=)
KR (1) KR101730216B1 (https=)
CN (1) CN103237554B (https=)
IN (1) IN2013MN00607A (https=)
SG (1) SG189167A1 (https=)
WO (1) WO2012042618A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3296392A4 (en) * 2015-05-14 2018-11-21 Advanced Cell Technology and Engineering Ltd. Method for producing frozen mesenchymal cells and method for producing implantable therapeutic member
KR101848904B1 (ko) * 2015-11-12 2018-04-13 김동구 발모 조절 중추 세포인 모유두 세포의 증식과 생존 및 세포 활성화 촉진 작용을 지닌 기능성 조절 항체 및 이의 용도
DE102015119880B4 (de) * 2015-11-17 2018-05-24 Technische Universität Berlin Verfahren zur Herstellung von Haarfollikeln und de novo Papillen sowie deren Verwendung für in vitro Tests und in vivo Implantate
JP7092310B2 (ja) * 2017-08-22 2022-06-28 国立大学法人横浜国立大学 複数の再生毛包原基の製造方法、毛包組織含有シートの製造方法、毛髪再生用キット及び発毛促進又は抑制物質をスクリーニングする方法
JP7385842B2 (ja) * 2019-09-17 2023-11-24 学校法人東京理科大学 観察方法、測定方法、解析方法、定量方法、およびキット
TW202241459A (zh) * 2020-12-23 2022-11-01 南韓商生物歐賽加有限責任公司 miRNA—485抑制劑用於誘導毛髮生長之用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005132813A (ja) * 2003-10-06 2005-05-26 Shiseido Co Ltd 毛包を再生するための組成物、方法及び再生された毛包を担持する動物
US20100197019A1 (en) * 2005-09-30 2010-08-05 Koei Toyoshima Method for Cultivation of Hair Follicular Dermal Sheath Cells

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9925964D0 (en) * 1999-11-03 1999-12-29 Jahoda Colin A B Hair transplantation
US20040247572A1 (en) * 2001-09-06 2004-12-09 Ritsuro Ideta Hair follicle-reconstitution system and animal carrying the same
EP1688484B1 (en) * 2003-10-06 2017-06-28 Shiseido Company, Ltd. Method of preparing hair papilla cell preparation, composition and method for regenerating hair follicle and animal having regenerated hair follicle
JPWO2005053763A1 (ja) 2003-12-05 2007-06-28 株式会社バイオインテグレンス 発毛方法
WO2005071063A1 (en) * 2004-01-27 2005-08-04 The Hospital For Sick Children Methods of making and using skin-derived stem cells
WO2005120575A1 (ja) * 2004-06-14 2005-12-22 Shiseido Company, Ltd. 毛包形成抑制能を有する遺伝子の抑制又は毛包形成誘導能を有する遺伝子の活性化による毛包再生方法
JP5386180B2 (ja) * 2006-02-28 2014-01-15 ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク 真皮細胞のコンパクト凝集のための方法
JP5097387B2 (ja) 2006-11-16 2012-12-12 ライオン株式会社 人工皮膚

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005132813A (ja) * 2003-10-06 2005-05-26 Shiseido Co Ltd 毛包を再生するための組成物、方法及び再生された毛包を担持する動物
US20100197019A1 (en) * 2005-09-30 2010-08-05 Koei Toyoshima Method for Cultivation of Hair Follicular Dermal Sheath Cells

Also Published As

Publication number Publication date
CN103237554B (zh) 2015-08-12
IN2013MN00607A (https=) 2015-09-11
CN103237554A (zh) 2013-08-07
EP2623106A1 (en) 2013-08-07
KR20130112872A (ko) 2013-10-14
US20130212724A1 (en) 2013-08-15
HK1183790A1 (en) 2014-01-10
US20160193140A1 (en) 2016-07-07
EP2623106A4 (en) 2014-03-26
WO2012042618A1 (ja) 2012-04-05
EP2623106B1 (en) 2018-05-23
US10172332B2 (en) 2019-01-08
SG189167A1 (en) 2013-05-31

Similar Documents

Publication Publication Date Title
KR101077760B1 (ko) 인간 제대의 워튼 젤리로부터의 전구세포
Wang et al. Skin microbiome promotes mast cell maturation by triggering stem cell factor production in keratinocytes
US10172332B2 (en) Method for regenerating hair follicles using CD36-expressing dermal sheath cells
US8563309B2 (en) Primitive organ-like structure comprising keratinocytes and hair papilla cells
KR20110022713A (ko) 인간 만능줄기세포로부터 인간 피부 대체물을 제조하는 방법
JP6626245B2 (ja) 再構成皮膚の作製用の組成物および方法
WO2014200025A1 (ja) 毛包形成用の組成物の品質管理方法
JP5686957B2 (ja) Cd36発現性結合組織鞘細胞を含有する毛包を再生するための組成物
JP4689175B2 (ja) 毛包を再生するための組成物、方法及び再生された毛包を担持する動物
CN1968713B (zh) 通过抑制具有毛囊形成抑制能力的基因或通过活化具有毛囊形成诱导能力的基因而再生毛囊的方法
KR101974672B1 (ko) 재현된 두피 모델 및 활성 분자 스크리닝 방법
Dong et al. Enrichment of epidermal stem cells by rapid adherence and analysis of the reciprocal interaction of epidermal stem cells with neighboring cells using an organotypic system
JP4373652B2 (ja) 毛包再構成系およびその担持動物
HK1183790B (en) Composition for regenerating follicle which contains cd36-expressing connective tissue sheath cells
JP4264322B2 (ja) 毛乳頭細胞調製品の調製方法
JP2008306938A (ja) 毛乳頭細胞培養方法
JP2006028169A (ja) 毛包形成抑制能を有する遺伝子の抑制による毛包再生方法
JP6101066B2 (ja) メラノサイト集団の調製方法
JP2010284110A (ja) 結合組織鞘細胞のcd36発現を指標とする発毛又は育毛促進剤をスクリーニングする方法
Gharzi Dermal and epidermal cell functions in the growth and regeneration of hair follicles and other skin appendages
Higgins Molecular and cellular basis of Exogen and Anagen induction
Reding Thy1 is a Conserved Marker of Spermatogonial Stem Cells in the Pre-pubertal Bull Testis
Langton Development and Repair Roles of Epidermal Stem Cell Populations

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

P22-X000 Classification modified

St.27 status event code: A-2-2-P10-P22-nap-X000

D13-X000 Search requested

St.27 status event code: A-1-2-D10-D13-srh-X000

D14-X000 Search report completed

St.27 status event code: A-1-2-D10-D14-srh-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

FPAY Annual fee payment

Payment date: 20200304

Year of fee payment: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20250420

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

H13 Ip right lapsed

Free format text: ST27 STATUS EVENT CODE: N-4-6-H10-H13-OTH-PC1903 (AS PROVIDED BY THE NATIONAL OFFICE); TERMINATION CATEGORY : DEFAULT_OF_REGISTRATION_FEE

Effective date: 20250420

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20250420