KR101725261B1 - Composition for the dissolving of the alcohol consistencies in blood and the neutralizing poisons of the hangover - Google Patents

Abstract

The present invention relates to a composition for alcohols decomposition and hangover which contains an algae extract as an active ingredient, and relates to a composition for algae extract containing a seaweed of at least one selected from the group consisting of grasses, The herbicidal composition of the present invention is excellent in the ability to decompose alcohol by containing at least one kind of herbal medicine selected from the group consisting of Puerariae radix, Galati, Corn oil, Schizandra chinensis, Licorice root,

Description

TECHNICAL FIELD The present invention relates to a composition for alcohols containing a seaweed extract as an active ingredient and a composition for a hangover,

The present invention relates to a composition having an excellent alcohol decomposing ability and containing an algae extract as an active ingredient and having excellent alcohol decomposition efficiency and hangover resolution.

Alcohol in the body is transported to other organs and parts of the liver or body. Liver-transported alcohol is oxidized by alcohol dehydrogenase and aldehyde dehydrogenase to acetic acid, and some of it is excreted by urine or carbon. do.

Specifically, when the alcohol is metabolized in the body, it is oxidized to acetaldehyde by an alcohol dehydrogenase, and the acetaldehyde is again oxidized to acetate by an aldehyde dehydrogenase. At this time, excess NADH Respectively.

In particular, alcohol metabolism in the liver is regulated by factors affecting the activity of NAD, alcohol dehydrogenase, and aldehyde dehydrogenase. The activity of alcohol dehydrogenase occurs mainly in hepatocytes and also occurs in the intestinal track as a guest. In addition, the activity of alcohol dehydrogenase is inhibited by pyrazole, rice seeding and the like, reactivated by zinc, cobalt and the like and promoted by calcium, EDTA, 2-mercaptoethanol and the like. Aspartate maalanin increases the activity of alcohol dehydrogenase by promoting the regeneration of NAD, and asparagine reacts with acetaldehyde to produce adducts which lower the concentration of acetaldehyde to weaken biological toxicity.

Ethanol is known to have various effects on liver metabolism depending on its intake. Acetaldehyde (NADH) and NADH produced in the oxidation process are more damaging to hepatocytes than ethanol itself. Acetaldehyde is mostly oxidized to acetate, but when the concentration is above 16 mM, about 60% of acetaldehyde is not metabolized, which is harmful to not only hepatocytes but also other tissues, especially the brain, and is known to cause hangover.

People drink alcohol and get drunk, causing problems with their linguistic, behavioral, and mental aspects and causing alcoholic liver disorders. Therefore, people have been interested in resolving hangovers, and have traditionally used honey, galangengtang, bean sprout soup, burger soup, mung bean, etc. in Korea. More specifically, Ducks, ducks, and ducks have been used to relieve hangovers.

However, although the various methods of hangover resolution have been proposed as described above, there is no proposal of a quick-acting prescription that can immediately stabilize alcohol decomposition ability or hangover resolution at the same time.

In the past, the relationship between hepatic detoxification activity and alcohol degradation activity was investigated using alcohol dehydrogenase inhibitor, hinoki wood, mulberry tree extract, japonica extract, and leafy debris hydrolyzate, and the effect of alcohol extract on the alcohol enzyme activity was studied .

Korean Patent No. 0524659 Korean Patent No. 0562460 Korean Patent Publication No. 2014-0137549

It is an object of the present invention to provide a composition having an excellent alcohol decomposing ability and containing an algae extract as an active ingredient and having excellent alcohol decomposition efficiency and hangover resolution.

Another object of the present invention is to provide a health functional food containing the algae extract as an active ingredient.

In order to accomplish the above object, the composition of the present invention which is excellent in the alcohol decomposing effect and hangover resolution includes Gloiopeltis tenax , Gloiopeltis furcata , Chondrus ocellatus , and Monostroma nitidum ) as an active ingredient.

The composition having excellent alcohol decomposition efficiency and hangover resolution may further comprise a herbal extract containing at least one kind of herbal medicine selected from the group consisting of Hovenia dulcis, Pueraria littoralis, Galvus, Cornus sylvestris, Schizandra chinensis, Licorice, Bokbunja and Jujube.

The algae extract and the herbal extract may be mixed at a weight ratio of 2: 8 to 4: 6.

The algae extract may be a geranium extract.

The seaweed extract can be extracted by mixing seaweed, water, a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof at a weight ratio of 1: 0.1 to 1.0.

The extraction temperature of the algae extract may be 50 to 100 < 0 > C.

Wherein the herbal extract comprises 80 to 150 parts by weight of crab root, 80 to 150 parts by weight of crab, 20 to 70 parts by weight of corn oil, 20 to 70 parts by weight of Omija, 20 to 70 parts by weight of licorice, 20 to 70% And 20 to 70 parts by weight of jujube.

The herbal extract may be extracted by mixing the herbal medicine with water, a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof at a weight ratio of 1: 5 to 20.

The extraction temperature of the herbal extract may be 100-170 < 0 > C.

In another aspect of the present invention, there is provided a health functional food having an alcohol-decomposing effect and a good hangover resolution, which comprises at least one seaweed extract containing at least one seaweed selected from the group consisting of pulses, May be contained as an active ingredient.

The health functional food having excellent alcohol decomposition efficiency and hangover resolution may further include a herbal extract containing at least one kind of herbal medicine selected from the group consisting of Hovenia dulcis, Puerariae radix, Galaga, Sansui oil, Omija, licorice, bokbunja and jujube .

The composition of the present invention, which is excellent in the alcohol decomposing effect and hangover resolution, is excellent in decomposing alcohol by including algae extract and oriental herb extract, and thus can greatly help hangover by alcohol, as well as liver health.

The present invention relates to a composition having an excellent alcohol decomposing ability and containing an algae extract as an active ingredient and having excellent alcohol decomposition efficiency and hangover resolution.

Hereinafter, the present invention will be described in detail.

The composition of the present invention having excellent alcohol decomposition efficiency and hangover resolution contains seaweed extract and Oriental herb extract as active ingredients.

In order to produce the algae extract, at least one kind of seaweed selected from the group consisting of pulverizer, unglazed crab, bean curd, and monogloss are respectively washed with water and then dried.

Next, each of the seaweeds prepared above and the extraction solvent are mixed at a weight ratio of 1: 0.1 to 1.0, preferably 1: 0.2 to 0.7, at 50 to 100 ° C, preferably 70 to 80 ° C, Preferably 0.5 to 2 hours, to prepare an extract.

The extraction solvent is water, a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof, preferably water. The mixed solvent is not particularly limited, but methanol, ethanol, butanol or propanol of 20 to 80% is exemplified.

When the weight ratio of seaweed to water or alcohol is out of the range, the effective amount of seaweed can be extracted in the extract in a small amount.

Also, in order to produce the herbal extract, at least one herbal medicine selected from the group consisting of Hovenia dulcis, Pueraria littoralis, Galvus, Sansui oil, Schizandra chinensis, Licorice, Rubus and Jujube is washed.

Next, the herbal medicine and the extraction solvent are mixed at a weight ratio of 1: 5 to 20, preferably 1: 9 to 15, at 100 to 170 ° C, preferably 110 to 130 ° C for 0.1 to 10 hours , Preferably 2 to 5 hours, to prepare an extract.

The extraction solvent is water, a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof, preferably water. The mixed solvent is not particularly limited, but methanol, ethanol, butanol or propanol of 20 to 80% is exemplified.

When the weight ratio of the herbal medicine to the water or the alcohol is out of the range, the effective amount of the herbal extract may be extracted in the extract in a small amount.

Preferably, the herbal extract comprises 80 to 150 parts by weight of crab root, 80 to 150 parts by weight of crab, 20 to 70 parts by weight of corn oil, 20 to 70 parts by weight of omija, 20 to 70 parts by weight of licorice, 20 to 70 parts by weight and 20 to 70 parts by weight of jujube; If it is outside the above range, the alcohol decomposition ability may be lowered.

The algae extract and the herbal extract are mixed at a weight ratio of 2: 8 to 4: 6, preferably 2: 8. When the weight ratio of the algae extract and the herbal extract is out of the above range, have.

The algae extract and herbal extract prepared as described above may be used as the extract itself or may be pulverized for convenient use. In the method of pulverizing the algae extract and herbal extract, the extract is concentrated under reduced pressure to reduce its volume, and then lyophilized by a freeze dryer to be pulverized.

The composition containing the seaweed extract and the oriental herb extract of the present invention as an active ingredient and having excellent alcohol decomposition efficiency and hangover resolution can be obtained by adding the seaweed extract and Oriental herb extract in an amount of 0.01 to 80% by weight, preferably 0.1 to 50% by weight, By weight.

The composition having excellent alcohololysis efficiency and hangover resolution can be formulated into various oral or parenteral administration forms.

Examples of formulations for oral administration include tablets, pills, hard, soft capsules, liquids, suspensions, emulsions, syrups, granules and the like. These formulations may contain, in addition to the active ingredient, a diluent such as lactose, dextrose, (For example, silica, talc, stearic acid and magnesium or calcium salts thereof and / or polyethylene glycol), in addition to the active ingredient (s). The tablets may also contain binders such as magnesium aluminum silicate, starch paste, gelatin, tragacanth, methylcellulose, sodium carboxymethylcellulose and / or polyvinylpyrrolidine, optionally mixed with starch, agar, alginic acid Or a disintegrating or boiling mixture such as its sodium salt and / or an absorbent, a colorant, a flavoring agent and a sweetening agent. The formulations may be prepared by conventional mixing, granulating or coating methods.

Representative examples of formulations for parenteral administration include injectable preparations, and water, Ringer's solution, isotonic saline or suspensions may be mentioned as a solvent for the injectable preparation. The sterile, fixed oils of the injectable preparations may be used as a solvent or suspending medium, and any non-irritating fixed oils, including mono-, di-glycerides, may be used for this purpose. The injectable preparation may be a fatty acid such as oleic acid.

The dose of the composition of the present invention which is excellent in the alcohol decomposing effect and the hangover resolution containing the extract of seaweed and the herbal extract as an active ingredient varies according to the age, sex, weight and severity of the disease of the patient, The dose is not more than 300 mg per 1 kg, preferably 10 to 200 mg per 1 kg of body weight per day, but is not limited thereto.

The health functional food containing the seaweed extract and the oriental herb extract of the present invention as an active ingredient and having excellent alcohol decomposition efficiency and hangover resolution contains 0.01 to 80% by weight of algae extract and Oriental herb extract, respectively, based on the total weight of the health functional food .

The health functional food may be in the form of a capsule, tablet, powder, granule, liquid, ring, flaky, paste, syrup, gel, jelly and jute for the purpose of supplementing nutrients that may be lacking in daily eating or supplementing functional raw materials useful in the human body And is easily manufactured and operated once.

In addition, the health functional food may contain at least one selected from the group consisting of glucose, citric acid, liquid oligosaccharide, corn syrup, soybean lecithin, butter, vegetable hardening oil, skim milk, sugar, margarine, salt, starch, And can be prepared by using commonly used components such as sodium bicarbonate and sugar ester.

It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the present invention. Such variations and modifications are intended to be within the scope of the appended claims.

<Production Example>

Production Example 1:

The hair was washed with water for 1 hour, washed with hot air for 24 hours at 40 ° C, mixed with 1: 0.5 part by weight of distilled water and distilled water, and extracted with hot water at 80 ° C for 1 hour.

Production Example 2. Water-soluble extract

The extract was prepared in the same manner as in Preparation Example 1, but using a pulverizer instead of a chrysanthemum.

Production Example 3

The preparation was carried out in the same manner as in Preparation Example 1, but using an unglazed gazelles instead of Chenopodium soap to prepare an extract.

Production Example 4. Single Paraffin Water Extract

The extract was prepared in the same manner as in Preparation Example 1 except that chrysanthemum morifolium was used instead of chrysanthemum.

Production Example 5. Ethanol extract of Chenopodium albumen

The procedure of Preparation Example 1 was repeated except that 80% ethanol was used instead of water.

Production Example 6. Herb extract

100 parts by weight of hinoki, 100 parts by weight of crabgrass, 100 parts by weight of crab, 50 parts by weight of marine oil, 50 parts by weight of omija, 50 parts by weight of licorice, 50 parts by weight of bokbunja and 50 parts by weight of jujube, Water at a weight ratio of 1: 11 and extracted with hot water at 110 ° C for 3 hours to prepare a herbal extract.

<Test Example>

Test Example 1. ADH measurement

Alcohol dehydorogenase (ADH) activity was measured to determine the effect of the extract prepared according to Preparation Examples 1 to 6 on alcohol degradation.

First, 10 μl of the alcohol used as the substrate was added to the yeast ( Saccharomyces 10 μl of ADH (Sigma Aldrich) derived from S. cerevisiae was added, and 2 μl of 0.1 M NAD was added thereto. Then, 1 mg / ml of each extract was added and reacted at 37 ° C. The activity of ADH was determined by measuring the conversion of NAD to NADH at 340 nm. As a control, 10 .mu.l of alcohol was mixed with 10 .mu.l of ADH and 2 .mu.l of 0.1 M NAD.

The microplate reader was a Bio-Rad (America) company and the UV-Visible spectra were measured using a Varian Cary 100 Concystem UV-Visible spectrometer (Varian, Australia) Respectively.

At this time, relative activity (%) was measured with no algae extract added as a control, and the results are shown in Table 1 below. In addition, in Preparation Example 6, relative activity (%) was measured using a control solution to which no herbal extract was added. The ADH activity of each control was 100%.

division Production Example 1 Production Example 2 Production Example 3 Production Example 4 Production Example 5 Production Example 6 ADH activity (%) 120 105 110 95 70 147

As shown in Table 1, it was confirmed that the water extract of Angelica keiskei and the herbal extract of Preparation Example 1 had the best ADH activity.

On the other hand, the ethanol extracts of Jeungdubu showed less than 100% of ADH activity, which is lower than that of the control.

Although the extracts of Jeungduk and the mixed extracts of the seaweed extracts themselves have excellent ADH activity, the ADH activity is slightly lower than that of commercially available hangover beverages. Therefore, the herbal extract and the mixed extracts were added to the extracts .

<Examples>

Control 1.

Water was used.

Control 2.

A commercially available hangover drink containing hinoki fruit extract, glutamate, yeast extract mixed powder, and Hwanggi lotus extract powder was used.

Example 1. Purple water extract + Oriental herb extract

The extract of Jeungduk water prepared in Preparation Example 1 and the extract of Oriental herb prepared in Preparation Example 6 were mixed at a weight ratio of 2: 8 to prepare an extract.

Example  2. Jin Duc  Water extract + herbal extract

The extract was prepared in the same manner as in Example 1 except that the water extract of Angelica keiskei and the herbal extract were mixed at a weight ratio of 4: 6.

Example  3. Mixed algae water extract + herbal extract

The extracts prepared according to Preparation Examples 1 to 4 were mixed at a weight ratio of 1: 1: 1: 1, and the mixed seaweed extract and the herbal extract prepared in Preparation Example 6 were mixed at a weight ratio of 2: 8, .

Example  4. Jin Duc  Water extract + herbal extract

The extract was prepared in the same manner as in Example 1 except that the water extract of Angelica keiskei and the herbal extract were mixed at a weight ratio of 1: 9.

Example  5. Jin Duc  Water extract + herbal extract

The extract was prepared in the same manner as in Example 1 except that the water extract of Angelica keiskei and the herbal extract were mixed at a weight ratio of 5: 5.

< Test Example >

Test Example  2. ADH  Measurement (in vitro)

Was measured in the same manner as in Test Example 1 above.

division Control 1 Control 2 Example 1 Example 2 Example 3 Example 4 Example 5 ADH activity (%) 100.0 125.1 157.7 155.3 140.5 130.5 118.2

As shown in Table 2 above, the extracts prepared according to Examples 1 to 4 of the present invention showed excellent ADH activity as compared with Controls 1 and 2.

It was confirmed that the extracts of Examples 3 to 5 exhibited rather low ADH activity as compared with the ADH activity of the herbal extract (147%) of Preparation Example 6. [

Therefore, it is expected that ADH activity will be improved by using JEON extract alone instead of mixed seaweed extract. Also, it is necessary to mix Jeonduk extract and JEON extract with weight ratio of 2: 8 to 4: 6 to obtain better ADH Lt; / RTI &gt;

Test Example 3. Measurement of ALDH (in vitro)

The activity of aldehyde dehydrogenase (ALDH) was determined by mixing 10 μl of substrate acetaldehyde (10 μl), 2 μl of enzyme ALDH (10 μl) and 0.1 M NADH, and adding 1 mg / ml of each extract 1 &lt; / RTI &gt; ADH.

division Control 1 Control 2 Example 1 Example 2 Example 3 Example 4 Example 5 ALDH activity (%) 100.0 170.2 213.4 207.7 189.6 168.5 161.7

As shown in Table 3 above, the extracts prepared according to Examples 1 to 3 of the present invention showed excellent ALDH activity as compared with Controls 1 and 2.

However, the extracts prepared according to Examples 3 and 5 showed lower ALDH activity than the control 2.

Test Example  4. Blood alcohol concentration measurement (in vivo )

The rats used in the experiment were anesthetized by intraperitoneal injection of 300 mg / kg of urethane 30 minutes before the start of the experiment. 5 g of the extract prepared according to Control 1-2 and Example 1-3 was suspended in 10 ml of 0.1% CMC and orally administered to each mouse. After 30 minutes, pure ethanol was diluted with distilled water to a concentration of 8 mg / ml and orally administered to each experimental group at a concentration of 4 g / kg. 2 ml of blood was collected from the orbital vein 1 hour, 2 hours and 4 hours after ethanol administration. The blood was centrifuged at 4 ° C, serum was separated, and the amount of alcohol in the blood was measured using an ethanol analysis kit (Sigma, USA).

division Control 1 Control 2 Example 1 Example 2 Example 3 Example 4 Example 5 Blood alcohol concentration (mg / dL) 1 hours 0.15 0.09 0.07 0.07 0.08 0.10 0.11 2 hours 0.10 0.07 0.05 0.05 0.07 0.08 0.08 4 hours 0.07 0.05 0.01 0.02 0.04 0.06 0.07

As shown in Table 4, it was confirmed that the extracts prepared according to Examples 1 to 3 of the present invention had lower amounts of alcohol in blood than those of Controls 1 and 2 at all times. In particular, the extract of Example 1 showed that the amount of alcohol in the blood was extremely small after 4 hours.

However, the extracts prepared according to Examples 3 and 5 were found to have a larger amount of alcohol in blood than the control 2 at all times.

Test Example  5. ALT and AST  Measure

ALT and AST measurements were performed to investigate the effects of extracts and alcohols on liver function.

Serum ALT and AST were measured by the Reitman-Frankel unit / dl method, which was used as an index for evaluating liver damage by administering the extracts and alcohols of Controls 1-2 and 1-3.

Dosage (g / kg) ALT AST Normal living group 25.04 + - 1.24 121.25 ± 18.2 40% alcohol 1 g / kg 111.32 + - 2.40 503.41 + - 19.48 Control 1 10 ml / kg + 40% alcohol 1 g / kg 31.01 + 1.94 132.18 ± 16.43 Control 2 10 ml / kg + 40% alcohol 1 g / kg 27.09 ± 1.48 141.09 ± 21.17 Example 1 10 ml / kg + 40% alcohol 1 g / kg 25.53 + - 2.44 135.05 + 14.3 Example 2 10 ml / kg + 40% alcohol 1 g / kg 26.01 + - 1.08 136.89 + - 16.08 Example 3 10 ml / kg + 40% alcohol 1 g / kg 31.51 + - 1.27 145.27 ± 20.04 Example 4 10 ml / kg + 40% alcohol 1 g / kg 33.16 + 2.01 150.11 + 14.58 Example 5 10 ml / kg + 40% alcohol 1 g / kg 37.46 ± 1.99 156.49 + 13.84

As shown in Table 5 above, the extracts prepared according to Examples 1 to 5 of the present invention hardly cause any change in enzyme activity as compared with the normal living group, and thus the extract prepared according to Examples 1 to 5 has hepatotoxicity , It seems that it does not have a significant effect. It can be seen that the extracts prepared according to Examples 1 to 5 do not affect normal liver function.

Thus, it was indirectly confirmed that the extract prepared according to Examples 1 to 5 could be used as a useful substance for hepatic dysfunction caused by stress, liver disease caused by alcohol, and the like.

Test Example  6. Measure respiratory alcohol concentration

Nine individuals of 20 to 25 years old were ingested 20 ml of distilled water 2 ml / kg_body weigh in 1 minute, and 100 ml of the extracts of Control 1-2 and Example 1-3 were taken, and alcohol was consumed by an aerobic alcohol meter After 10, 30, 60, 90 and 120 minutes, respiratory alcohol concentration was measured.

division Control 1 Control 2 Example 1 Example 2 Example 3 Example 4 Example 5 Breathing alcohol concentration (%) 10 minutes 0.015 0.005 0.003 0.004 0.004 0.05 0.07 30 minutes 0.019 0.008 0.004 0.005 0.006 0.09 0.11 60 minutes 0.017 0.007 0.004 0.006 0.005 0.08 0.09 90 minutes 0.01 0.005 0.001 0.002 0.003 0.06 0.06 120 minutes 0.005 0.000 0.000 0.000 0.000 0.01 0.02

As shown in Table 6 above, respiratory alcohol concentration increased after 10 minutes in all groups and showed high respiration alcohol concentration up to 60 minutes. In all groups, respiratory alcohol concentration began to decrease after 90 minutes. In particular, the extracts prepared according to Examples 1 to 3 of the present invention showed a higher reduction effect than the control 1 and 2, and no alcohol was measured at 120 minutes.

Furthermore, the extract of Example 1 had very little respiratory alcohol concentration from 90 minutes.

However, the extracts prepared according to Examples 3 and 5 showed higher respiratory alcohol concentrations at all times than the control 2.

Test Example  7. Cytotoxicity measurement

The cytotoxicity of the extracts prepared in Examples 1 to 3 was measured.

Cytotoxicity was measured by the method of Rochem et al. In order to carry out the test in the safety concentration range of the sample. Cells (2 × 10 ⁵ cells / well) (RAW 264.7) were seeded in 24-well plates and cultured for 24 hours. After that, the medium was removed and 1 mL of the medium containing 3% of the serum in which the extract was dissolved was dispensed and cultivation was continued for 24 hours. After 24 hours, 0.25 mL of XTT-PMS solution (1 mg XTT and 10 g PMS / mL of MEM without phenol red) was added to each well and incubated for another 2 hours. The degree of cytotoxicity was determined by measuring the absorbance of formazan at 450 nm using a microplate reader. The medium was MEM supplemented with 10% (v / v) fetal bovine serum (FBS), 0.5% (v / v) 50 g / mL streptomycin, 50 IU / mL penicillin, 0.125 g / mL fungizone, 3.024 g sodium bicarbonate And incubated at 37 ℃, 5% CO _2, 95% humidified air. The concentration of the extract 1 &lt; / RTI &gt; ug / ml.

division Example 1 Example 2 Example 3 Example 4 Example 5 Cell viability (%) 99.5 99.2 98.3 95.12 91.01

As shown in Table 7, the extracts prepared according to Examples 1 to 5 of the present invention were found to have excellent cell viability.

Hereinafter, formulation examples of the composition containing the extract of the present invention will be described, but the present invention is not intended to be limited thereto but is specifically described.

Preparation Example 1. Preparation of powder

500 mg of the extract powder obtained in Example 1

Lactose 100 mg

Talc 10 mg

The above components are mixed and filled in airtight bags to prepare powders.

Formulation Example 2. Preparation of tablets

300 mg of the extract powder obtained in Example 1

Corn starch 100 mg

Lactose 100 mg

Magnesium stearate 2 mg

After mixing the above components, tablets are prepared by tableting according to the usual preparation method of tablets.

Formulation Example 3. Preparation of capsules

200 mg of the extract powder obtained in Example 1

Crystalline cellulose 3 mg

Lactose 14.8 mg

Magnesium stearate 0.2 mg

The above components are mixed according to a conventional capsule preparation method and filled in gelatin capsules to prepare capsules.

Formulation Example 4. Preparation of injection

600 mg of the extract powder obtained in Example 1

180 mg mannitol

Sterile sterilized water for injection 2974 mg

Na ₂ HPO _4, 12H ₂ O 26 mg

It is prepared by the above-mentioned component content per ampoule according to the usual injection preparation method.

Formulation example  5. Liquid  Produce

4 g of the extract powder obtained in Example 1

10 g per isomer

5 g mannitol

Purified water quantity

Each component was added and dissolved in purified water according to the usual liquid preparation method, and the lemon flavor was added in an appropriate amount. Then, the above components were mixed, and purified water was added thereto. The whole was adjusted to 100 g with purified water, To prepare a liquid agent.

Formulation example  6. Preparation of granules

1,000 mg of the extract powder obtained in Example 1

Vitamin mixture quantity

70 ug of vitamin A acetate

Vitamin E 1.0 mg

Vitamin B1 0.13 mg

0.15 mg of vitamin B2

Vitamin B6 0.5 mg

Vitamin B12 0.2 ug

Vitamin C 10 mg

Biotin 10 ug

Nicotinic acid amide 1.7 mg

Folic acid 50 ug

Calcium pantothenate 0.5 mg

Mineral mixture quantity

1.75 mg of ferrous sulfate

0.82 mg of zinc oxide

Magnesium carbonate 25.3 mg

Potassium monophosphate 15 mg

Secondary calcium phosphate 55 mg

Potassium citrate 90 mg

Calcium carbonate 100 mg

Magnesium chloride 24.8 mg

The composition ratio of the above-mentioned vitamins and minerals is comparatively comparatively mixed with the granules according to the preferred embodiment. However, the blending ratio may be arbitrarily changed, and the above components are mixed according to the ordinary granule preparation method, Can be prepared and used in the manufacture of a health functional food composition according to a conventional method.

Formulation example  7. Manufacture of functional beverages

1,000 mg of the extract powder obtained in Example 1

Citric acid 1,000 mg

100 g of oligosaccharide

Plum concentrate 2 g

Taurine 1 g

Purified water was added and the entire 900 ml

The above components were mixed according to a conventional health drink manufacturing method, and the mixture was stirred and heated at 85 DEG C for about 1 hour. The solution thus prepared was filtered and sterilized in a sterilized 2 L container, It is used in the production of the functional beverage composition of the invention.

Although the composition ratio is a mixture of the components suitable for the preferred beverage as a preferred embodiment, the blending ratio may be arbitrarily varied according to the regional and national preferences such as the demand level, the demanding country, and the intended use.

Claims (13)

The composition of claim 1, wherein the composition has an alcohol-decomposing effect and a hangover resolution. [3] The composition according to claim 1, wherein the composition having excellent alcohol-decomposing activity and hangover resolution is one or more herbal extracts containing at least one herbal medicine selected from the group consisting of Hovenia dulcis, Pueraria crassa, Galvus, Sansui oil, Omija, licorice, The composition according to any one of claims 1 to 3, [3] The composition according to claim 2, wherein the extract and the herbal extract are mixed at a weight ratio of 2: 8 to 4: 6. delete [Claim 2] The method according to claim 1, wherein the extract is a mixture of water and water, a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof at a weight ratio of 1: 0.1 to 1.0. A composition having excellent hangover resolution. The composition according to claim 1, wherein the extraction temperature is 50 to 100 占 폚. [3] The herbal extract according to claim 2, wherein the herbal extract contains 80 to 150 parts by weight of crab root, 80 to 150 parts by weight of crab, 20 to 70 parts by weight of corn oil, 20 to 70 parts by weight of Omija, 20 to 70% 20 to 70 parts by weight of bokbun, 20 to 70 parts by weight of jujube, and the composition is excellent in the effect of alcohol decomposition and resolution of hangover. [3] The herbal extract according to claim 2, wherein the herbal extract is obtained by mixing water, a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof, at a weight ratio of 1: 5 to 20, . [3] The composition of claim 2, wherein the extraction temperature is 100 to 170 [deg.] C. Which is characterized by having an extract of Zinnia extract as an active ingredient. [Claim 11] The method according to claim 10, wherein the health functional food having excellent alcohol decomposition efficiency and hangover resolution is selected from the group consisting of herbal extracts containing at least one herbal medicine selected from the group consisting of Hovenia dulcis, Puerariae radix, Galvus, Wherein the alcohol-decomposing activity and the hangover-eliminating activity are excellent. 12. The health functional food according to claim 11, wherein the extract and the herbal extract are mixed at a weight ratio of 2: 8 to 4: 6. 12. The method of claim 11, wherein the health functional food is selected from the group consisting of capsules, tablets, powders, granules, liquids, rings, flakes, pastes, syrups, gels, Superior health functional foods.