KR101668447B1 - Composition for curing hanover and health functional foods composition comprising the same - Google Patents

Abstract

The present invention relates to a composition for relieving hangover and a health functional food containing the same, which comprises extracts of red ginseng, mountainous oil, omija, and ginseng, and further may contain red ginseng chips.

INDUSTRIAL APPLICABILITY The present invention has no side effects by using a herbal medicine component, has an excellent effect on hangover resolution, and can be provided with satisfactory intake satisfaction by including a ginger red ginseng chip.

Hangover, intake, satisfaction, red ginseng chip

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition for relieving hangovers,

The present invention relates to a composition for relieving hangover and a health functional food containing the same, and more particularly to a composition for relieving hangover comprising a herbal extract and a health functional food containing the same.

Modern people suffer from various stresses, lack of exercise, environmental pollution, etc., and heart function, liver function and gastrointestinal function are weakened and easily fatigued and often have fragile constitution. Because of this reality, various health supplements for the effect of tonic and fatigue of modern people are popular.

Although a variety of health foods are distributed in the market, there are relatively few products satisfying both of the effects and the satisfaction of ingestion, and there has been a steady consumer demand for them.

It is an object of the present invention to provide a composition for relieving hangover which is highly satisfactory in ingestion without side effects through herbal medicine extracts.

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It is still another object of the present invention to provide a health functional food for hangover marine products comprising the composition as described above.

In order to accomplish the above object, the composition for removing hangover according to one embodiment of the present invention comprises extracts of red ginseng, mountain syrup, omija, and tortoiseshell as an active ingredient.

The composition may further include red ginseng chips, and the red ginseng chips may be ginseng by at least one selected from the group consisting of honey, oligosaccharides, glucose and fructose.

The composition may contain 0.1 to 50 parts by weight of the red ginseng extract, 0.1 to 50 parts by weight of the extract of the vegetable oil, omija and tortoise, based on 100 parts by weight of the total composition, and 0.1 to 50 parts by weight of the red ginseng chip, .

The composition according to one embodiment of the present invention may have a liquid formulation, a gel formulation or a solid preparation.

In order to accomplish the above object, the composition for removing hangover according to one embodiment of the present invention comprises extracts of red ginseng, mountain syrup, omija, and tortoiseshell as an active ingredient.

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The composition for relieving hangover and the health functional food containing the same according to the present invention have no side effects by using herbal medicine components, have an excellent effect on the elimination of hangover, and provide excellent satisfaction of intake by including ginger red ginseng chips and the like.

The composition for relieving hangover according to one embodiment of the present invention includes an extract of a herbal medicine component such as red ginseng, marine oil, omija, and tortoise.

The ginseng radix contained in the composition for removing hangover according to one embodiment of the present invention is dried ginseng of Panax ginseng CA Meyer belonging to Araliaceae. Red ginseng is steamed dried ginseng. Its taste is slightly worn, its quality is flat, it enters into the spleen and lungs, and it is a typical medicine in oriental medicine. Its efficacy is in Daebo, It has sedative and excitatory effects on the central nervous system. It acts on the circulatory system and has the effect of preventing hypertension or arteriosclerosis. It has the action of arteriosclerosis, antioxidant, anti-fatigue, anti-radioactivity and hypoglycemic action. The major components are saponine (ginsenosides), panaxynol, beta-elemene, and maltol. Liquid extracts of red ginseng have been used to treat anemia, diabetes, insomnia, gastritis, hypertension, dyspepsia, overwork and fatigue, and have been studied to contain various triterpene glycosides called saponins (Baranov AI, J. Ethnopharmacol., 6, 339-353, 1982). In addition, red ginseng has been reported to have a variety of pharmacological effects including antihypertensive, cardiovascular, sedative, aphrodisiac, antioxidant and antioxidant effects (Gillis CN, Biochem. Pharmacol., 54, 1-8, 1997) .

The Macrocarpium officinale Sieb. Et Zucc. Contained in the composition for relieving the hangover according to one embodiment of the present invention is a deciduous sago tree in which the golden flowers are gathered before the leaves in the early spring, It belongs to the cornaceae. These acidic fruit oils include crystalline organic acids, gallic acid, malic acid, and wine acids, and the fruit shells include iridoid glycosides such as moronide, roganin, and the like. In the case of bronchial asthma treatment, the kidneys are taken with medicinal medicine, astringent medicines, sweating frequently, when urine comes out frequently, back pain, and when the moon is uneven.

Schizandra chinensis BAILLON , one of the basic components of the hangover-relieving composition according to one embodiment of the present invention, is a deciduous, woody plant belonging to Magnoliaceae, and is vine-like, and its fruit and seeds are used as a medicine. The main ingredient of Schizandrin, Gomisin, Citral, α-Ylangene, Matic acid, Citric acid, etc., There is a pharmacological action such as Jinhae (鎭 咳) action, geomorphic action, contraction of the uterus, antibacterial action, hypotensive action, arteriosclerosis action and transaminase lowering action. Especially, (Symptoms of fever and chest tightness in the body), to quickly recover from fatigue caused by physical labor, to strengthen cardiac function, and to improve blood circulation, thereby preventing memory loss or slowing down of thinking ability. Also, in modern medicine, it is clinically well known that Omija functions to normalize SGPT by acting on injured liver and to reduce hepatomegaly.

In addition, Cuscuta chinensis Lamak , a component of the composition for removing hangover according to an embodiment of the present invention, is a dried Cuscuta japonica Choisy seed, which contains about 40 mg% of provitamin A, It is sweet and sweet and the nature is plain. It is known as a medicinal product that mainly protects the liver and kidneys, brightens the eyes, helps the Yangs and strengthens the kidney function.

The above-mentioned red ginseng, marine oil, omija and algae are used in the form of extracts extracted with water or a C ₁ to C ₄ lower alcohol such as ethanol or a mixture thereof. In the case of lower alcohols, the concentration of alcohol is 0.1 to 100%, preferably 70% or more.

The extraction method may be a conventional extraction method such as a hot water extraction method or a sputum extraction method and is not particularly limited as far as it is possible to extract the maximum effective ingredient from each herbal medicine described above.

In addition, the composition for removing hangover according to an embodiment of the present invention may further include red ginseng chips. Red ginseng chips are finely divided red ginseng chips, and these red ginseng chips can be used in the form of glycyrrhizin. The gums of red ginseng chips are made of honey, glucose or fructose which helps to regain fatigue and refreshing, but also to facilitate the bowel movement such as isomaltooligosaccharide, fructooligosaccharide, galactooligosaccharide, xyloglucose, maltooligosaccharide Oligosaccharides, or oligosaccharides. In the case of the red ginseng chips as described above, not only the effect specific to red ginseng but also the synergistic effect due to the nutritional ingredients peculiar to honey, oligosaccharide, glucose and fructose, as well as the chewing feeling and the satisfaction of ingestion due to the taste thereof .

The composition for removing hangover according to one embodiment of the present invention may include 0.1 to 50 parts by weight of red ginseng extract and 0.1 to 50 parts by weight of mixed herbal extract based on 100 parts by weight of the whole composition.

In the case of containing red ginseng chips, the content may be in the range of 0.1 to 50 parts by weight.

The composition for removing hangover according to one embodiment of the present invention can provide excellent liver function improving effect and satisfactory intake when each component is used within the above-mentioned range.

In addition, the composition for removing hangover according to an embodiment of the present invention may further comprise suitable carriers, excipients and diluents conventionally used in the production of the composition.

The composition for removing hangover according to one embodiment of the present invention may have various oral formulations in a convenient form for ingestion, and may have formulations of, for example, a liquid preparation, a gel or a gum.

In addition, the preferred amount of the composition for removing hangover according to one embodiment of the present invention may be appropriately selected by those skilled in the art, although it varies depending on the health state of the body, the body weight, the degree of disease, and the like. However, for the desired effect, it is preferable to take the composition for removing hangover according to one embodiment of the present invention at 1 g to 5 g, preferably 2 g to 4 g per day. The administration can be taken once a day, or divided into several times. The dose is not intended to limit the scope of the invention in any way.

The composition for removing hangover according to one embodiment of the present invention as described above may be provided in a general food for hangover, or a health functional food. There is no particular limitation on the kind of the food. Examples of the food to which the hangover-removing composition can be added include dairy products including drinks, meat, sausage, bread, biscuits, rice cakes, chocolates, candies, snacks, confectionery, pizza, ramen noodles, Various soups, beverages, alcoholic beverages, and vitamin complexes, and includes all common healthy foods.

Hereinafter, the present invention will be described in more detail with reference to Experimental Examples, Examples and Comparative Examples. However, the following Experimental Examples, Examples, and Comparative Examples are for illustrative purposes only and are not intended to limit the scope of the present invention.

<Experimental Example>

1. Preparation of extracts and red ginseng chips for each herbal medicine

Each of the extracts may be separately prepared and mixed as described below to complete the composition according to one embodiment of the present invention.

1) Preparation of red ginseng extract

① After selecting and washing the red ginseng for 4 years or more in accordance with the standards and specifications specified in the Health Functional Food Code, water and ethanol are mixed and placed in an extractor and repeated 3-5 times at 65 ~ 75 ℃ for 10 ~ 15 hours And the active ingredient of red ginseng was extracted.

② The extract was pressure-filtered through a 250-mesh filter, transferred to a vacuum concentrator, and concentrated at a pressure of 500 to 1000 mmHg at a temperature of 60 to 80 ° C. to obtain a concentrated brix of 60 to 70 brix.

2) Manufacture of extracts of corn oil, omija, and soil extract

① The quality of the product is good, and the weight ratio of the mixed raw material and purified water in the ratio of 1: 1: 1, weight ratio of corn oil, omija, And extracted at 80 ° C or higher for 5 to 7 hours to extract an active ingredient.

(2) The extract was cooled to room temperature, filtered using a microfilter (1 μm), concentrated under reduced pressure to a solid content of 50% or more, and then sterilized by heating at 90 ° C. for 10 to 20 minutes.

3) Manufacture of red ginseng chips

① Wash ginseng for 4 years or more as prescribed by the Ginseng Industrial Act and remove impurities and diseased parts such as impurities, then crush them and then boil them at 70 ~ 95 ℃ for 3-5 hours.

② Fresh ginseng and fructo-oligosaccharide were added to the ginseng, homogenously mixed and then dipped in 50 ~ 90 ℃ for 5 ~ 10 hours.

③ Red ginseng chips were collected and sterilized at 80 ℃ for 2 ~ 3 hours.

2. Preparation of composition for removing hangover

The composition for removing hangover according to one embodiment of the present invention comprising extracts of red ginseng, corn oil, omija and algae, and optionally red ginseng chips was prepared as shown in Table 1 below.

The composition for removing hangover was prepared in a gel type formulation. Specifically, it is as follows

① raw materials

The product was purchased from domestic and foreign countries, which were in conformity with the standards of Food Code, Health Function Food Code, and Food Additives Code.

② Weighing

The raw materials suitable for the quality control test were precisely weighed using an electronic balance at the specified mixing ratio.

③ Mixed

When the temperature of the contents reaches 85 ± 5 ° C while stirring, the mixture is mixed in a mixer for 30 to 60 minutes, and stirred, and the mixture is stirred. Respectively. After confirming that the xanthan gum was sufficiently stirred, the operation was carried out.

④ Process inspection

pH, solids content, viscosity, and microorganism.

⑤ filling

Immediately after filling the contents of the filling hopper and the temperature of 85 ± 5 ° C, filling operation was performed and the sealing state of the pouch was confirmed.

3. Preparation of Comparative Compositions

Comparative compositions having the compositions shown in Table 1 below were prepared.

unit
(Parts by weight) Red ginseng extract Corn oil, Omija,
And the
extract Red ginseng chip Xanthan gum honey Fructose
oligosaccharide Purified water Example 1 10 10 0 0.5 10 44.5 25 Example 2 10 10 15 0.3 10 44.7 10 Comparative Example 10 0 0 0.7 10 44.3 35

4. Blood alcohol test

For each of five 7-week-old hairless mice, the composition of Example 2 and the composition of Comparative Example were orally administered at a concentration of 200 mpk once a day for 5 days.

On the 5th day, each sample was administered to dull mice. After 3 hours, 0.26 ml of 20% ethanol solution was administered. After 1 hour, 3 hours, and 5 hours, the blood samples were collected by autopsy. Then, serum was separated from collected blood, and blood alcohol concentration was analyzed and shown in FIG.

The alcohol analysis method is as follows

1) A sample was prepared by mixing 3 ml of the reaction mixture (potassium phosphate buffer solution pH 9 + NAD tablet) used for analyzing the alcohol content in the blood with 0.1 ml of blood.

2) The sample was incubated for 3 minutes at 20 &lt; 0 &gt; C.

3) The absorbance of the sample was measured (A1) at 340 nm using a UV spectrometer (UV-1601, manufactured by Shimadzu Corporation).

4) 0.05 ml of alcohol dehydrogenase was added to the sample.

5) The sample was incubated at 20 [deg.] C for about 5 minutes.

6) The absorbance of the sample was measured (A2) at 340 nm using a UV spectrometer (UV-1601, manufactured by Shimadzu Corporation).

7) The values obtained above were substituted into the following formulas to calculate the alcohol concentration.

Alcohol concentration = 0.7259 / 3.6 X DELTA A

DELTA A = sample (A2-A1) -blank (A2-A1)

As shown in FIG. 1, after the administration of the 20% ethanol solution, the concentration of alcohol in the blood after one hour was analyzed. As a result, it was found that the average value of the alcohol concentration in the hairless mice administered with the composition of the comparative example was about 235 mg% The results are shown in Table 2. The results are shown in Table 1. The results are shown in Table 1. The results are shown in Table 1. The results are shown in Table 1. The results are shown in Table 1. Accordingly, it was confirmed that the composition of Example 2 corresponding to the composition according to one embodiment of the present invention has an effect of inhibiting blood alcohol concentration.

4. Hangover resolution panel test

After drinking the liquid composition of the composition of Example 2 and the composition of the comparative example, ten adult male and female subjects were questioned about the hangover improvement efficacy.

Ten adult males and females were allowed to consume alcohol equivalent to one and a half bottle of shochu, followed by ingesting 50 ml of the liquid composition of the composition of Example 2 and the comparative example. After 5 hours of ingestion, the questionnaire survey was conducted to determine whether it was effective in relieving hangovers. After 6 to 7 points, the effect was very good, 4 to 5 points were effective, and 2 to 3 points were effective , And a score of 1 indicates no effect, and the results are summarized in Table 2 below.

effect
Very good effect
good usually effect
none Example 2 3 people 5 people 1 person 1 person Comparative Example 0 people 2 people 4 people 4 people

From the results shown in Table 2, it can be seen that when the composition of Example 2, which is a composition according to one embodiment of the present invention, is consumed, the hangover improvement effect is significantly higher than that of the composition of Comparative Example.

5. Intake Satisfaction Test

Ten adult males and females received 15 g of the gel formulation of the compositions of Examples 1 and 2 and Comparative Examples, respectively, and the degree of satisfaction with the intake was measured on a 5-point scale and shown in Fig.

As shown in Fig. 2, Example 2 including the grated red ginseng chips provided the highest degree of satisfaction with ingestion. Accordingly, it can be seen that the satisfaction of ingestion is increased when the composition according to an embodiment of the present invention includes red ginseng chips.

Next, a formulation example of the composition according to the present invention will be described. The following formulation examples are not intended to limit the invention in any way, but merely to illustrate them.

&Lt; Formulation Example 1 >

A liquid agent was prepared by a conventional method according to the composition shown in Table 3 below.

Compounding ingredient Mixing ratio (parts by weight) Red ginseng extract 10 Corn oil, Omiza, and Tozan extract 10 Red ginseng chip 15 honey 15 Fructooligosaccharide 15 Citric acid 0.2 Purified water 34.8

&Lt; Formulation Example 2 >

A gel was prepared by a conventional method according to the composition shown in Table 4 below.

Compounding ingredient Mixing ratio (parts by weight) Red ginseng extract 15 Extract of corn oil, omija, and Tozan 15 Red ginseng chip 20 honey 15 Fructooligosaccharide 25 Citric acid 0.2 Xanthan gum One Purified water 8.8

&Lt; Formulation Example 3 >

The compositions were prepared in the usual way according to the compositions shown in Table 5 below.

In the preparation of the gypsum, the following ingredients were concentrated for more than 5 hours and then mixed for more than 7 hours to prepare a gypsum.

Compounding ingredient Mixing ratio (parts by weight) Red ginseng extract 20 Extract of corn oil, omija, and Tozan 20 honey 25 Fructooligosaccharide 33.8 Citric acid 0.2 Xanthan gum One

FIG. 1 is a graph showing the hangover resolution performance of Example 2, which is a composition according to an embodiment of the present invention, and Comparative Example. FIG.

FIG. 2 is a graph showing satisfaction of ingestion in Examples 1 and 2 and Comparative Examples according to an embodiment of the present invention. FIG.

Claims (8)

Red ginseng extract; And extracts of mixed herbal medicines consisting of marine oil, omija and algae; And a red ginseng chip as an active ingredient, The red ginseng extract and the mixed herbal extract were mixed at a weight ratio of 1: 1, The red ginseng extract was obtained by extracting with a mixed solvent of water and ethanol, The red ginseng extract is contained in an amount of 10 parts by weight based on the total weight of the composition, The vegetable oil, the omija and the soil in the mixed herbal medicines are mixed at a weight ratio of 1: 1: 1, The extract of the mixed herb medicine is obtained by extracting with water, The extract of the mixed herb medicine is contained in an amount of 10 parts by weight based on the total weight of the composition, Wherein the red ginseng chips are contained in an amount of 15 parts by weight based on the total weight of the composition. delete The method according to claim 1, Wherein the red ginseng chips are dipped by at least one selected from the group consisting of honey, oligosaccharides, glucose and fructose. delete delete The method according to claim 1, Wherein the composition is a liquid, gel or solid. delete A health functional food comprising the food composition for hangover according to any one of claims 1, 3, and 6.

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