KR101634032B1 - 디메틸-벤조산 화합물 - Google Patents
디메틸-벤조산 화합물 Download PDFInfo
- Publication number
- KR101634032B1 KR101634032B1 KR1020147036136A KR20147036136A KR101634032B1 KR 101634032 B1 KR101634032 B1 KR 101634032B1 KR 1020147036136 A KR1020147036136 A KR 1020147036136A KR 20147036136 A KR20147036136 A KR 20147036136A KR 101634032 B1 KR101634032 B1 KR 101634032B1
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- dimethyl
- mmol
- amino
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 C*c1c(C)ccc(C(OC)=O)c1C Chemical compound C*c1c(C)ccc(C(OC)=O)c1C 0.000 description 2
- XOUSVGYROKBECN-UHFFFAOYSA-N Cc1c2[nH]c(-c3c(C)ccc(Cl)n3)[o](C)c2cc(C(OC)=O)c1 Chemical compound Cc1c2[nH]c(-c3c(C)ccc(Cl)n3)[o](C)c2cc(C(OC)=O)c1 XOUSVGYROKBECN-UHFFFAOYSA-N 0.000 description 2
- VXCDYRLZDFQUCJ-UHFFFAOYSA-N Cc1ccc(C(OC)=O)c(C)c1N Chemical compound Cc1ccc(C(OC)=O)c(C)c1N VXCDYRLZDFQUCJ-UHFFFAOYSA-N 0.000 description 2
- XUQPMKBXUPRNTI-UHFFFAOYSA-N CC(C)(C)[Si+](C)(C)OC(CCC1)CN1c1cc(-c([nH]c2c(C)cc3)[o](C)c2c3C(OC)=O)c(C)cc1 Chemical compound CC(C)(C)[Si+](C)(C)OC(CCC1)CN1c1cc(-c([nH]c2c(C)cc3)[o](C)c2c3C(OC)=O)c(C)cc1 XUQPMKBXUPRNTI-UHFFFAOYSA-N 0.000 description 1
- AXLMAJOGCCKNES-UHFFFAOYSA-N CC(C)(C)[Si](C)(C)OCC(CC1)CN1c1nc(C(Nc(c(C)c2)c(C)cc2C(OC)=O)=O)c(C)cc1 Chemical compound CC(C)(C)[Si](C)(C)OCC(CC1)CN1c1nc(C(Nc(c(C)c2)c(C)cc2C(OC)=O)=O)c(C)cc1 AXLMAJOGCCKNES-UHFFFAOYSA-N 0.000 description 1
- YGKPKBZDFYZVET-UHFFFAOYSA-N CC(C)(C)[Si](C)(C)OCC(CCC1)CN1c(cc1)cc(-c([nH]c2c(C)cc3)[o](C)c2c3C(OC)=O)c1F Chemical compound CC(C)(C)[Si](C)(C)OCC(CCC1)CN1c(cc1)cc(-c([nH]c2c(C)cc3)[o](C)c2c3C(OC)=O)c1F YGKPKBZDFYZVET-UHFFFAOYSA-N 0.000 description 1
- FKSCJWMSCNBRCV-UHFFFAOYSA-N CC(CC1)(C(CC2CC2)CN1c1nc(C(Nc2c(C)ccc(C(OC)=O)c2C)=O)c(C)cc1)O Chemical compound CC(CC1)(C(CC2CC2)CN1c1nc(C(Nc2c(C)ccc(C(OC)=O)c2C)=O)c(C)cc1)O FKSCJWMSCNBRCV-UHFFFAOYSA-N 0.000 description 1
- DMKYRXNSYOVNLS-UHFFFAOYSA-N CC(CC1)(CCN1c1nc(C(Nc2c(C)ccc(C(O)=O)c2C)=O)c(C)cc1)O Chemical compound CC(CC1)(CCN1c1nc(C(Nc2c(C)ccc(C(O)=O)c2C)=O)c(C)cc1)O DMKYRXNSYOVNLS-UHFFFAOYSA-N 0.000 description 1
- WKYOOHCRKQWPEE-UHFFFAOYSA-N CCOC(c1cc(C)c2[nH]c(-c3c(C)ccc(N(CC4)CCC4=O)c3)[o](C)c2c1)=O Chemical compound CCOC(c1cc(C)c2[nH]c(-c3c(C)ccc(N(CC4)CCC4=O)c3)[o](C)c2c1)=O WKYOOHCRKQWPEE-UHFFFAOYSA-N 0.000 description 1
- SSPQOLHQGAFWCA-UHFFFAOYSA-N Cc(c(C(Nc1c(C)c(C(OC)=O)ccc1C)=O)c1)ccc1Br Chemical compound Cc(c(C(Nc1c(C)c(C(OC)=O)ccc1C)=O)c1)ccc1Br SSPQOLHQGAFWCA-UHFFFAOYSA-N 0.000 description 1
- CZQKTUBNPGCJNI-UHFFFAOYSA-N Cc(c(C(Nc1c(C)ccc(C(OC)=O)c1C)=O)c1)ccc1N(CC1)CCC1=O Chemical compound Cc(c(C(Nc1c(C)ccc(C(OC)=O)c1C)=O)c1)ccc1N(CC1)CCC1=O CZQKTUBNPGCJNI-UHFFFAOYSA-N 0.000 description 1
- ARSRTLJLMXSRPV-UHFFFAOYSA-N Cc(cc(cc1C)C(OC)=O)c1N Chemical compound Cc(cc(cc1C)C(OC)=O)c1N ARSRTLJLMXSRPV-UHFFFAOYSA-N 0.000 description 1
- WOJKYHBOHSQZDW-UHFFFAOYSA-N Cc(cc1)c(C(Nc(c(C)c2)c(C)cc2C(O)=O)=O)nc1N(CC1)CCC1O Chemical compound Cc(cc1)c(C(Nc(c(C)c2)c(C)cc2C(O)=O)=O)nc1N(CC1)CCC1O WOJKYHBOHSQZDW-UHFFFAOYSA-N 0.000 description 1
- JLLLNXJTBCOQFL-UHFFFAOYSA-N Cc(cc1)c(C(Nc2c(C)ccc(C(OC)=O)c2C)=O)nc1Cl Chemical compound Cc(cc1)c(C(Nc2c(C)ccc(C(OC)=O)c2C)=O)nc1Cl JLLLNXJTBCOQFL-UHFFFAOYSA-N 0.000 description 1
- ODSPBBWQVLWOPG-UHFFFAOYSA-N Cc(cc1)c(C(O)=O)nc1Cl Chemical compound Cc(cc1)c(C(O)=O)nc1Cl ODSPBBWQVLWOPG-UHFFFAOYSA-N 0.000 description 1
- XWPSWOKQWBNRDW-UHFFFAOYSA-N Cc(cc1)c(C(OC)=O)nc1Cl Chemical compound Cc(cc1)c(C(OC)=O)nc1Cl XWPSWOKQWBNRDW-UHFFFAOYSA-N 0.000 description 1
- ODSPBBWQVLWOPG-UHFFFAOYSA-M Cc(cc1)c(C([O-])=O)nc1Cl Chemical compound Cc(cc1)c(C([O-])=O)nc1Cl ODSPBBWQVLWOPG-UHFFFAOYSA-M 0.000 description 1
- RCLFUUDVSZFSBS-UHFFFAOYSA-N Cc(cc1)c2[nH]c(-c3c(C)ccc(N(CC4)CCC4O)n3)[o](C)c2c1C(OC)=O Chemical compound Cc(cc1)c2[nH]c(-c3c(C)ccc(N(CC4)CCC4O)n3)[o](C)c2c1C(OC)=O RCLFUUDVSZFSBS-UHFFFAOYSA-N 0.000 description 1
- TUJPKHVAHICTNG-UHFFFAOYSA-N Cc(cc1)c2[nH]c(-c3c(C)ccc(N(CCC4)CC4O)c3)[o](C)c2c1C(O)=O Chemical compound Cc(cc1)c2[nH]c(-c3c(C)ccc(N(CCC4)CC4O)c3)[o](C)c2c1C(O)=O TUJPKHVAHICTNG-UHFFFAOYSA-N 0.000 description 1
- SEENCYZQHCUTSB-UHFFFAOYSA-N Cc(ccc(Br)c1)c1C(O)=O Chemical compound Cc(ccc(Br)c1)c1C(O)=O SEENCYZQHCUTSB-UHFFFAOYSA-N 0.000 description 1
- YSUYMIMLCZOBJX-UHFFFAOYSA-N Cc(ccc(C(OC)=O)c1C)c1[N+]([O-])=O Chemical compound Cc(ccc(C(OC)=O)c1C)c1[N+]([O-])=O YSUYMIMLCZOBJX-UHFFFAOYSA-N 0.000 description 1
- NOYIOZREHKWBKQ-UHFFFAOYSA-N Cc(ccc(N(CC1)CCC11OCCO1)c1)c1C(Nc1c(C)ccc(C(OC)=O)c1C)=O Chemical compound Cc(ccc(N(CC1)CCC11OCCO1)c1)c1C(Nc1c(C)ccc(C(OC)=O)c1C)=O NOYIOZREHKWBKQ-UHFFFAOYSA-N 0.000 description 1
- USAPMJKOJBISGB-UHFFFAOYSA-N Cc(ccc(N(CC1)CCC1=O)c1)c1C(Nc1c(C)c(C(O)=O)ccc1C)=O Chemical compound Cc(ccc(N(CC1)CCC1=O)c1)c1C(Nc1c(C)c(C(O)=O)ccc1C)=O USAPMJKOJBISGB-UHFFFAOYSA-N 0.000 description 1
- QKXHVYYKUKYHAP-UHFFFAOYSA-N Cc(ccc(N(CC1)CCC1O)c1)c1C(Nc1c(C)c(C(O)=O)ccc1C)=O Chemical compound Cc(ccc(N(CC1)CCC1O)c1)c1C(Nc1c(C)c(C(O)=O)ccc1C)=O QKXHVYYKUKYHAP-UHFFFAOYSA-N 0.000 description 1
- BUHUKEBDJUYKGW-UHFFFAOYSA-N Cc1c2[nH]c(-c3c(C)ccc(N(CC4)CCC4O)c3)[o](C)c2cc(C(O)=O)c1 Chemical compound Cc1c2[nH]c(-c3c(C)ccc(N(CC4)CCC4O)c3)[o](C)c2cc(C(O)=O)c1 BUHUKEBDJUYKGW-UHFFFAOYSA-N 0.000 description 1
- BGRBMHSIVCCOEB-UHFFFAOYSA-N Cc1c2[nH]c(-c3c(C)ccc(N4CC(CO)CCC4)c3)[o](C)c2cc(C(OC)=O)c1 Chemical compound Cc1c2[nH]c(-c3c(C)ccc(N4CC(CO)CCC4)c3)[o](C)c2cc(C(OC)=O)c1 BGRBMHSIVCCOEB-UHFFFAOYSA-N 0.000 description 1
- QFOYYQIUDDTVOT-UHFFFAOYSA-N Cc1ccc(C(OC)=O)c(C)c1NC(c1cc(Br)cc2ccccc12)=O Chemical compound Cc1ccc(C(OC)=O)c(C)c1NC(c1cc(Br)cc2ccccc12)=O QFOYYQIUDDTVOT-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261665956P | 2012-06-29 | 2012-06-29 | |
| US61/665,956 | 2012-06-29 | ||
| US201361778969P | 2013-03-13 | 2013-03-13 | |
| US61/778,969 | 2013-03-13 | ||
| PCT/US2013/046685 WO2014004230A1 (en) | 2012-06-29 | 2013-06-20 | Dimethyl-benzoic acid compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20150013335A KR20150013335A (ko) | 2015-02-04 |
| KR101634032B1 true KR101634032B1 (ko) | 2016-06-27 |
Family
ID=48746667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020147036136A Expired - Fee Related KR101634032B1 (ko) | 2012-06-29 | 2013-06-20 | 디메틸-벤조산 화합물 |
Country Status (40)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110015221A1 (en) * | 2003-12-23 | 2011-01-20 | Pierre Fabre Medicament | Pharmaceutical composition of vinflunine which is intended for parenteral administration preparation method thereof and use of same |
| TWI572597B (zh) * | 2012-06-29 | 2017-03-01 | 美國禮來大藥廠 | 二甲基－苯甲酸化合物 |
| EP2765128A1 (en) * | 2013-02-07 | 2014-08-13 | Almirall, S.A. | Substituted benzamides with activity towards EP4 receptors |
| TWI636046B (zh) | 2013-05-17 | 2018-09-21 | 美國禮來大藥廠 | 苯氧基乙基二氫－１ｈ－異喹啉化合物 |
| JP6200596B2 (ja) | 2013-12-17 | 2017-09-20 | イーライ リリー アンド カンパニー | ジメチル安息香酸化合物 |
| US10189788B2 (en) | 2014-09-09 | 2019-01-29 | Bayer Pharma Aktiengesellschaft | Substituted N,2-diarylquinoline-4-carboxamides and the use thereof as anti-inflammatory agents |
| CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
| PE20191616A1 (es) * | 2017-04-10 | 2019-11-05 | Bayer Ag | N-ariletil-2-arilquinolina-4-carboxamidas sustituidas y su uso |
| TWI770157B (zh) * | 2017-04-10 | 2022-07-11 | 德商拜耳廠股份有限公司 | 經取代之n-芳基乙基-2-胺基喹啉-4-甲醯胺及其用途 |
| PE20191787A1 (es) | 2017-05-18 | 2019-12-24 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituidos |
| KR102612140B1 (ko) | 2017-05-18 | 2023-12-08 | 이도르시아 파마슈티컬스 리미티드 | 피리미딘 유도체 |
| AR111808A1 (es) | 2017-05-18 | 2019-08-21 | Idorsia Pharmaceuticals Ltd | Derivados de pirimidina como moduladores del receptor de pge2 |
| EA201992676A1 (ru) | 2017-05-18 | 2020-05-06 | Идорсия Фармасьютиклз Лтд | Фенильные производные в качестве модуляторов pge2 рецепторов |
| US11325899B2 (en) | 2017-05-18 | 2022-05-10 | Idorsia Pharmaceuticals Ltd | Benzofurane and benzothiophene derivatives as PGE2 receptor modulators |
| JP7816164B2 (ja) | 2020-11-13 | 2026-02-18 | 小野薬品工業株式会社 | Ｅｐ４拮抗薬と免疫チェックポイント阻害物質との併用によるがん治療 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7705035B2 (en) | 2006-06-12 | 2010-04-27 | Merck Frosst Canada Ltd. | Indoline amide derivatives as EP4 receptor ligands |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1270615B (it) | 1994-07-14 | 1997-05-07 | Smithkline Beecham Farma | Uso di derivati di chinolina |
| JP2000355551A (ja) * | 1999-06-15 | 2000-12-26 | Nikken Chem Co Ltd | 医薬組成物 |
| MXPA06003123A (es) | 2003-09-22 | 2006-05-31 | Euro Celtique Sa | Agentes terapeuticos utiles para el tratamiento del dolor. |
| US7326732B2 (en) | 2004-02-12 | 2008-02-05 | Pharmagene Laboratories Limited | EP2 receptor agonists |
| KR20090122931A (ko) * | 2007-03-26 | 2009-12-01 | 아스테라스 세이야쿠 가부시키가이샤 | 오르니틴 유도체 |
| WO2012004293A2 (de) | 2010-07-08 | 2012-01-12 | Bayer Cropscience Ag | Insektizide und fungizide wirkstoffkombinationen |
| CA2831978A1 (en) | 2011-03-03 | 2012-09-07 | Universitat Des Saarlandes | Biaryl derivatives as selective 17beta-hydroxysteroid dehydrogenase type 2 inhibitors |
| TWI572597B (zh) * | 2012-06-29 | 2017-03-01 | 美國禮來大藥廠 | 二甲基－苯甲酸化合物 |
-
2013
- 2013-06-11 TW TW102120796A patent/TWI572597B/zh not_active IP Right Cessation
- 2013-06-13 AR ARP130102078 patent/AR091431A1/es unknown
- 2013-06-13 JO JOP/2013/0178A patent/JO3221B1/ar active
- 2013-06-20 SI SI201330576A patent/SI2867218T1/sl unknown
- 2013-06-20 MX MX2014015952A patent/MX347476B/es active IP Right Grant
- 2013-06-20 PL PL13734249T patent/PL2867218T3/pl unknown
- 2013-06-20 AP AP2014008165A patent/AP4063A/en active
- 2013-06-20 ES ES13734249.9T patent/ES2623099T3/es active Active
- 2013-06-20 SG SG11201408629QA patent/SG11201408629QA/en unknown
- 2013-06-20 EA EA201492140A patent/EA025531B1/ru not_active IP Right Cessation
- 2013-06-20 ME MEP-2017-83A patent/ME02655B/me unknown
- 2013-06-20 IN IN2356MUN2014 patent/IN2014MN02356A/en unknown
- 2013-06-20 PT PT137342499T patent/PT2867218T/pt unknown
- 2013-06-20 LT LTEP13734249.9T patent/LT2867218T/lt unknown
- 2013-06-20 PE PE2014002531A patent/PE20150185A1/es active IP Right Grant
- 2013-06-20 DK DK13734249.9T patent/DK2867218T3/en active
- 2013-06-20 NZ NZ701894A patent/NZ701894A/en not_active IP Right Cessation
- 2013-06-20 RS RS20170231A patent/RS55756B1/sr unknown
- 2013-06-20 US US13/922,277 patent/US8642768B2/en not_active Expired - Fee Related
- 2013-06-20 CA CA2875572A patent/CA2875572C/en not_active Expired - Fee Related
- 2013-06-20 HR HRP20170540TT patent/HRP20170540T1/hr unknown
- 2013-06-20 BR BR112014029551A patent/BR112014029551A2/pt not_active IP Right Cessation
- 2013-06-20 EP EP13734249.9A patent/EP2867218B1/en active Active
- 2013-06-20 KR KR1020147036136A patent/KR101634032B1/ko not_active Expired - Fee Related
- 2013-06-20 CN CN201380030138.XA patent/CN104334540B/zh not_active Expired - Fee Related
- 2013-06-20 MY MYPI2014703973A patent/MY172860A/en unknown
- 2013-06-20 AU AU2013280779A patent/AU2013280779B2/en not_active Ceased
- 2013-06-20 HU HUE13734249A patent/HUE032398T2/en unknown
- 2013-06-20 JP JP2015520305A patent/JP6114824B2/ja active Active
- 2013-06-20 WO PCT/US2013/046685 patent/WO2014004230A1/en not_active Ceased
- 2013-12-04 US US14/096,469 patent/US8933098B2/en not_active Expired - Fee Related
-
2014
- 2014-11-24 ZA ZA2014/08631A patent/ZA201408631B/en unknown
- 2014-11-28 TN TN2014000500A patent/TN2014000500A1/fr unknown
- 2014-12-03 CR CR20140554A patent/CR20140554A/es unknown
- 2014-12-11 IL IL236218A patent/IL236218A/en active IP Right Grant
- 2014-12-17 GT GT201400289A patent/GT201400289A/es unknown
- 2014-12-17 DO DO2014000286A patent/DOP2014000286A/es unknown
- 2014-12-18 CO CO14278424A patent/CO7160064A2/es unknown
- 2014-12-26 CL CL2014003537A patent/CL2014003537A1/es unknown
-
2015
- 2015-01-05 PH PH12015500008A patent/PH12015500008B1/en unknown
-
2017
- 2017-04-12 CY CY20171100435T patent/CY1118830T1/el unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7705035B2 (en) | 2006-06-12 | 2010-04-27 | Merck Frosst Canada Ltd. | Indoline amide derivatives as EP4 receptor ligands |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR20150013335A (ko) | 디메틸-벤조산 화합물 | |
| KR101653476B1 (ko) | 페녹시에틸 피페리딘 화합물 | |
| EP3083554B1 (en) | Dimethylbenzoic acid compounds | |
| KR101807981B1 (ko) | 페녹시에틸 시클릭 아민 유도체 및 ep4 수용체 조절제로서의 그의 활성 | |
| JP2004512324A (ja) | Ｎｍｄａ受容体拮抗剤としてのアミド誘導体 | |
| US9000043B2 (en) | Phenoxyethoxy compounds | |
| KR101798315B1 (ko) | 페녹시에틸 디히드로-1h-이소퀴놀린 화합물 | |
| EA022043B1 (ru) | Сульфоновые соединения в качестве лигандов 5-htрецептора | |
| HK1203936B (en) | Dimethyl-benzoic acid compounds useful for the treatment of inflammatory conditions | |
| AU2014265762B2 (en) | Phenoxyethyl dihydro-1H-isoquinoline compounds |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
|
| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| D13-X000 | Search requested |
St.27 status event code: A-1-2-D10-D13-srh-X000 |
|
| D14-X000 | Search report completed |
St.27 status event code: A-1-2-D10-D14-srh-X000 |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
|
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
St.27 status event code: A-1-2-D10-D22-exm-PE0701 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
St.27 status event code: A-2-4-F10-F11-exm-PR0701 |
|
| PR1002 | Payment of registration fee |
St.27 status event code: A-2-2-U10-U12-oth-PR1002 Fee payment year number: 1 |
|
| PG1601 | Publication of registration |
St.27 status event code: A-4-4-Q10-Q13-nap-PG1601 |
|
| FPAY | Annual fee payment |
Payment date: 20190327 Year of fee payment: 4 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 4 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 5 |
|
| PC1903 | Unpaid annual fee |
St.27 status event code: A-4-4-U10-U13-oth-PC1903 Not in force date: 20210622 Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE |
|
| PC1903 | Unpaid annual fee |
St.27 status event code: N-4-6-H10-H13-oth-PC1903 Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE Not in force date: 20210622 |