KR101625412B1 - Composition for preventing or treating cavity and periodontal disease comprising Ambrosia trifida extract or its fraction as effective component - Google Patents
Composition for preventing or treating cavity and periodontal disease comprising Ambrosia trifida extract or its fraction as effective component Download PDFInfo
- Publication number
- KR101625412B1 KR101625412B1 KR1020140161278A KR20140161278A KR101625412B1 KR 101625412 B1 KR101625412 B1 KR 101625412B1 KR 1020140161278 A KR1020140161278 A KR 1020140161278A KR 20140161278 A KR20140161278 A KR 20140161278A KR 101625412 B1 KR101625412 B1 KR 101625412B1
- Authority
- KR
- South Korea
- Prior art keywords
- extract
- fraction
- periodontal disease
- composition
- porphyromonas gingivalis
- Prior art date
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Botany (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Veterinary Medicine (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The present invention relates to a pharmaceutical composition for preventing or treating periodontal disease or periodontal disease, which comprises as an active ingredient an antimicrobial composition for a decubitus or periodontal bacteria containing a maple leaf pan grass extract or a fraction thereof as an active ingredient, a maple leaf pan grass extract or a fraction thereof And Dietary leaf extract or fraction thereof as an active ingredient, and to a health functional food composition for preventing or ameliorating tooth decay or periodontal disease.
Description
The present invention relates to a composition for preventing or treating periodontal disease and tooth decay, which comprises as an active ingredient, a maple leaf pan grass extract or a fraction thereof. More particularly, the present invention relates to a composition for preventing or treating periodontal disease, A pharmaceutical composition for prevention or treatment of tooth decay or periodontal disease containing the antimicrobial composition, maple leaf pan grass extract or fraction thereof as an active ingredient, and prevention of tooth decay or periodontal disease containing the extract of maple leaf porcine grass or its fraction as active ingredients Or improving health functional food composition.
A tooth is a tooth that is worm-wormed. The tooth's hard tissue is eroded and it is called a dental caries. Tooth decay is an infectious bacterial disease that causes part of the hard calcified tissue of the tooth to dissolve and break down and ultimately lose teeth. It is the most common periodontal disease.
Periodontitis is a chronic inflammatory disease caused by bacteria and toxins in the microbial plaque, which is caused by inflammation of the surrounding tissues of the teeth. Periodontal tissue that supports the teeth is gradually destroyed, causing the tooth to shake and eventually fall out. Periodontitis is an idiom and is often referred to as a periodontal disease. It is also called periodontal disease or periodontal disease. When periodontal disease occurs, the gingiva falls and the tooth root appears and the symptoms of syenin appear.
Dental medicine Various oral diseases including tooth decay, gingivitis and periodontal disease can be caused by various causes. The cause is divided into systemic cause and local cause, and the most important cause is local cause. The most important local cause is bacteria that reside in the mouth, that is, pathogenic microorganisms.
It is known in the human oral cavity that about 300 kinds of microorganisms are resident on the surface of the teeth, between the teeth and gums of the root portion, and on the surface of the tongue, and the presence of such microorganisms, Phenomenon. However, if proper oral hygiene activities are not performed, various oral diseases such as tooth decay, halitosis, gingivitis and periodontal disease may be caused by pathogenic microorganisms among the above-mentioned microorganisms, and in severe cases, teeth may be lost.
More specifically, a pathogenic microorganism resident in the oral cavity attaches to the surface of the tooth and forms a bacterial population called a plaque after a few hours. At first, a pathogenic microorganism attaches However, as progressive progression occurs, plaque is formed on the surface of the tooth under the gingiva. When the plaque is formed on the tooth surface, the pathogenic microorganism produces an acid by using the sugar introduced into the oral cavity, and this acid may cause tooth decay by demineralizing the main ingredient of the tooth.
Examples of the microorganisms that play the most important role in inducing oral diseases include Streptococcus mutans , Porphyromonas gingivalis , and the like. In particular, Streptococcus mutans is a causative organ of tooth decay and causes various oral diseases.
Conventionally, various kinds of antimicrobial agents including antibiotics having sterilization and bacteriostatic action against the microorganisms have been developed as inhibitors and remedies for cavity, periodontal disease or gingivitis. Conventional materials include fluorine and chlorine-containing compounds such as sodium copper chlorophyllin, sodium fluoride or benzethonium chloride, benzoic acid, , Allantoin, tocopheryl acetate, antiplasmic agents or antibiotics, and the like. However, in the case of the fluorine-chlorine-containing compound, safety of the human body is problematic. Antibiotics can cause systemic side effects, including diarrhea and vomiting, in the whole body, It is difficult to use it for a long period of time because it can induce homozygosity, so that it can be used only as a therapeutic agent. In addition, in the case of treatment by surgical treatment or mechanical therapy, there is a disadvantage that treatment is not easy.
Therefore, it is easy to prevent or treat as compared with surgical therapy or mechanical therapy, and there is no problem of tolerance or stability such as antibiotics even when used for a long time, and there is no problem of side effects such as a compound containing fluorine and chlorine components There is an urgent need to develop a composition for the prevention or treatment of oral diseases derived from natural materials, and there is an increasing demand for developing a composition capable of preventing or treating oral diseases from natural materials.
Korean Patent No. 1280868 discloses a pharmaceutical composition and a food composition for preventing or treating periodontal diseases and cavities containing an extract of YAKON as an active ingredient, Korean Patent Laid-Open No. 2011-0103267 discloses a composition comprising &Quot; oral cavity composition for prevention and treatment of periodontal disease ", which has an effective ingredient, is disclosed. However, no description has been made about a tooth cavity and a composition for the prevention or treatment of periodontal disease, .
The present invention has been made in view of the above needs, and the present inventors have found that methanol extract and its fractions of A. edulis exhibit antimicrobial activity against Streptococcus mutans, which is a carrot bacteria, and Porphyromonas gingivalis, a periodontal bacteria, , Thereby completing the present invention.
In order to solve the above problems, the present invention provides an antimicrobial composition for a decubitus bacteria or periodontal bacteria containing a maple leaf pan grass extract or a fraction thereof as an active ingredient.
The present invention also provides a pharmaceutical composition for prevention or treatment of tooth decay or periodontal disease, which comprises Diorama leaf extract or fraction thereof as an active ingredient.
In addition, the present invention provides a health functional food composition for preventing or ameliorating tooth decay or periodontal disease, which contains Diorama leaf Pig full extract or a fraction thereof as an active ingredient.
The composition containing the extract of Piggery Pig or Piggery Piggle Extract according to the present invention as an active ingredient exhibits excellent antimicrobial activity against Streptococcus mutans bacteria, which is a carrot bacteria, and Porphyromonas gingivalis bacteria, a periodontal bacteria, A pharmaceutical composition for prevention or treatment of tooth decay and periodontal disease such as disease prevention, dental calculus removal and decontamination, and a health functional food composition for prevention or improvement of tooth decay and periodontal disease.
In addition, the edible fowl grass extract or the fraction thereof of the present invention utilizes a plant to be discarded, and utilization of plant resources can be enhanced.
FIG. 1 shows the growth inhibition rate of Streptococcus mutans strain of Edible Foliage Pig Full Methanol Extract and its fractions. MeOH ex, methanol extract; Butanol fractions of BuOH fr, methanol extract; CHCl 3 fr, chloroform fraction of methanol extract; EtOAc fr, ethyl acetate fraction of methanol extract; Hexane fr, hexane fraction of methanol extract.
Fig. 2 shows the growth inhibition rates of P. falciparum methanol extract and fractions thereof against Porphyromonas gingivalis. MeOH ex, methanol extract; Butanol fractions of BuOH fr, methanol extract; CHCl 3 fr, chloroform fraction of methanol extract; EtOAc fr, ethyl acetate fraction of methanol extract; Hexane fr, hexane fraction of methanol extract.
In order to accomplish the object of the present invention, the present invention provides a composition for antimicrobial treatment against decubitus bacteria or periodontal bacteria containing the extract of Piglet Leaf Pig grass or a fraction thereof as an active ingredient.
In the antimicrobial composition according to an embodiment of the present invention, the cavity can be Streptococcus mutans , Streptococcus sobrinus and Lactobacillus salivarius , But are not limited to, Streptococcus mutans , and the periodontal bacteria may be selected from the group consisting of Porphyromonas gingivalis , Tannerella forsythia , Fusobacterium, nucleatum , Actinobacillus actinomycetemcomitans , and the like, preferably, but not limited to, Porphyromonas gingivalis .
In the antimicrobial composition according to an embodiment of the present invention, the extract of the maple leaf porcine grass may be an extract such as leaves, stalks or inflorescence of the plant, preferably leaves or inflorescence sites, It is not limited.
In addition, the maple leaf porcupine extract may be water, methanol, ethanol, propanol, butanol or a mixed solvent thereof extract of dried maple leaf porcine, preferably a methanol extract of dried maple leaf porcine grass, After drying for 2 ~ 4 days at 30 ~ 50 ℃, 75 ~ 85% of methanol was added to the dry weight of 400 ~ 600g, extracted with ultrasonic equipment, filtered ≪ / RTI >
In the antimicrobial composition according to one embodiment of the present invention, the fractions of the maple leaf porcupine extract are obtained by mixing 75 ~ 85% of methanol with 400 ~ 600g of dried leafy leaf porcine follicle, extracting using ultrasonic apparatus, Dissolved in water, and then adding chloroform or hexane (n-hexane).
The present invention also provides a pharmaceutical composition for prevention or treatment of tooth decay or periodontal disease, which comprises Diorama leafhopper extract or a fraction thereof as an active ingredient.
The term 'periodontal disease' is often referred to as a style, depending on the degree of disease gingivitis (gingivitis) and periodontitis (periodontitis) is divided into. It is a relatively light and fast-acting periodontal disease called gingivitis that is limited to gingiva or soft tissue, and it is called periodontitis when the inflammation progresses to the gums and the gums.
The extracts or fractions of the present invention may comprise suitable carriers, excipients and diluents conventionally used in the manufacture of pharmaceutical compositions.
The pharmaceutical dosage forms of the extracts or fractions of the present invention may be used in the form of their pharmaceutically acceptable salts, and may be used alone or in combination with other pharmaceutically active compounds as well as in suitable aggregates.
The extract or fraction according to the present invention can be formulated in the form of powders, granules, tablets, capsules, oral preparations such as suspensions, emulsions, syrups and aerosols, external preparations, suppositories and sterilized injection solutions according to a conventional method Can be used. Examples of carriers, excipients and diluents that can be contained in the extract or fraction include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, , Methylcellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate, mineral oil, and the like. In the case of formulation, a diluent or excipient such as a filler, an extender, a binder, a wetting agent, a disintegrant, or a surfactant is usually used. Solid formulations for oral administration include tablets, pills, powders, granules, capsules and the like, which may contain at least one excipient such as starch, calcium carbonate, sucrose, (sucrose), lactose, gelatin and the like. In addition to simple excipients, lubricants such as magnesium stearate and talc are also used. Examples of the liquid preparation for oral use include suspensions, solutions, emulsions, and syrups. In addition to water and liquid paraffin, simple diluents commonly used, various excipients such as wetting agents, sweeteners, fragrances, preservatives and the like may be included . Formulations for parenteral administration include sterilized aqueous solutions, non-aqueous solutions, suspensions, emulsions, freeze-dried preparations, and suppositories. Examples of the suspending agent include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like. As a suppository base, witepsol, macrogol,
The preferred dose of the extract or fraction of the present invention will vary depending on the condition and the weight of the patient, the degree of disease, the type of drug, the route of administration and the period of time, but can be appropriately selected by those skilled in the art. However, for the desired effect, the extract or fraction of the present invention is preferably administered at a daily dose of 0.0001 to 100 mg / kg, preferably 0.001 to 100 mg / kg. The administration may be carried out once a day or divided into several times. The dose is not intended to limit the scope of the invention in any way.
The extracts or fractions of the present invention can be administered to mammals such as rats, mice, livestock, humans, and the like in a variety of routes. All modes of administration may be expected, for example, by oral administration or by injection.
In addition, the present invention provides a health functional food composition for preventing or ameliorating tooth decay or periodontal disease, which contains Diorama leaf Pig full extract or a fraction thereof as an active ingredient.
The edible leaf extract or its fraction of the present invention exhibits excellent antimicrobial activity against Streptococcus mutans bacteria, which are carrot bacteria and Porphyromonas gingivalis bacteria, which are periodontal bacteria, and thus is useful for preventing or improving periodontal diseases such as tooth decay or gingivitis Can be used.
When the extract or fraction of the present invention is used as a food additive, the extract or fraction may be added as it is or may be used together with other food or food ingredients, and may be appropriately used according to a conventional method. The amount of the active ingredient to be mixed can be suitably determined according to its intended use (prevention, health or therapeutic treatment). Generally, the extract or fraction of the present invention is added in an amount of not more than 15 parts by weight, preferably not more than 10 parts by weight, based on the raw material, when the food or beverage is produced. However, in the case of long-term consumption intended for health and hygiene purposes or for health control purposes, the amount may be less than the above range, and since there is no problem in terms of safety, the active ingredient may be used in an amount exceeding the above range .
There is no particular limitation on the kind of the food. Examples of the food to which the extract or fraction can be added include dairy products such as meat, sausage, bread, chocolate, candy, snack, confectionery, pizza, ramen, other noodles, gums, ice cream, Alcoholic beverages, and vitamin complexes, all of which include health functional foods in a conventional sense.
Hereinafter, the present invention will be described in detail with reference to examples. However, the following examples are illustrative of the present invention, and the present invention is not limited to the following examples.
Experimental Method
Production Example 1. Preparation of a leaf flower leaf extract
The extracts of Ambrosia trifida were obtained from leaves, stems, and inflorescence parts of the leaves. The leaf vein and leaf spot of the maple leaf purple grass identified by the plant taxonomist were evenly cut to 2.54 cm using a cutting blade and then dried in a drying oven at 40 ° C for 3 days. Using a plant weight of about 500 g, 80% methanol was extracted using an ultrasonic apparatus. The liquid was filtered through a membrane filter (0.2 μm), and the solvent was removed in a vacuum to leave a methanol extract. Through this process, the fibrin among the components of the maple leaf swine pool is filtered through the purification process, and the maple leaf swine grass extract becomes a methanol extract mainly containing trace components of maple leaf swine grass. All solvents used were analytical grade, purchased from Sigma-Aldrich (USA) or Merck (USA).
Production Example 2. Preparation of fraction fractions of Edible Pork Leaf Extract
The fraction of maple leaf pork grass extract was obtained by dissolving maple leaf pork full methanol extract in water and then fractionated by using butanol, chloroform (CHCl 3 ), ethyl acetate or hexane (n-hexane). The fractionated sample was passed through a membrane filter (0.2 μm) before lyophilization and the solvent was removed under vacuum to leave only each fraction. These fractions were stored in a -20 ° C freezer until used. All solvents used were analytical grade, purchased from Sigma-Aldrich (USA) or Merck (USA).
Inhibition of growth of oral pathogens
The antimicrobial activities of extracts and fractions of P. falciparum were investigated by the inhibition of growth inhibition against oral pathogens.
Briefly, 1 × 10 6 cfu / ml of Streptococcus mutans UA159 (ATCC 700610) or Porphyromonas gingivalis W83 (ATCC BAA-1703) were added to 96-well plates , The maple leaf folate methanol extracts were treated at a concentration of 0.2 and 0.6 mg / ml, and the maple leaf folate fractions were treated at final concentrations of 0.008, 0.04 and 0.2 mg / ml, respectively. After incubation at 37 ° C for 24 hours while maintaining the anaerobic state, the growth inhibition rate of oral pathogens was analyzed.
Example 1: Antimicrobial activity measurement of Toadstool extract and fractions of Edamame leafhopper
The antimicrobial activity of the extracts and fractions of F. fructus from P. falciparum was confirmed in the leaves of F. fructus methanol extract and hexane fraction (Fig. 1). Butanol, chloroform and ethyl acetate fractions showed no inhibitory activity against the carrot bacteria. The hexane fraction showed a growth inhibition rate of 50% at a concentration of 0.04 mg / ml. The methanol extract had a higher concentration of 0.6 mg / ml The growth inhibition rate was 50%.
Example 2. Measurement of antimicrobial activity against periodontal bacteria in the leaves of Piggerygrass extract and fraction
The antimicrobial activity of P. falciparum methanol extracts and fractions against periodontal bacteria was confirmed in the leaves of Porphyra lucidum methanol extract, chloroform, ethyl acetate and hexane fractions (Fig. 2). Butanol fraction showed no inhibitory activity against periodontal bacteria. The chloroform fraction showed a growth inhibition rate of 100% at a concentration of 0.2 mg / ml. In the case of the hexane fraction, the inhibition rate was about 100 % Growth inhibition rate. The ethyl acetate fraction showed a growth inhibition rate of 50% or more at a concentration of 0.2 mg / ml. The methanol extract also showed higher antimicrobial activity against periodontal bacteria than the fraction.
From the above results, it was confirmed that the methanol extract and the hexane fraction of the maple leaf pork flea have antimicrobial activity against both the tooth decay bacteria and the periodontal bacteria and the chloroform fraction against the periodontal bacteria. Thus, it was confirmed that the above-mentioned Edible leaf extract or its fraction can be used for prevention or treatment of tooth decay or periodontal disease.
Claims (7)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020140161278A KR101625412B1 (en) | 2014-11-19 | 2014-11-19 | Composition for preventing or treating cavity and periodontal disease comprising Ambrosia trifida extract or its fraction as effective component |
| PCT/KR2015/011243 WO2016080666A2 (en) | 2014-11-19 | 2015-10-23 | Composition for preventing or treating dental caries and periodontal disease, containing extract of ambrosia trifida l. or fraction thereof as active ingredient |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020140161278A KR101625412B1 (en) | 2014-11-19 | 2014-11-19 | Composition for preventing or treating cavity and periodontal disease comprising Ambrosia trifida extract or its fraction as effective component |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20160059603A KR20160059603A (en) | 2016-05-27 |
| KR101625412B1 true KR101625412B1 (en) | 2016-05-31 |
Family
ID=56014653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020140161278A KR101625412B1 (en) | 2014-11-19 | 2014-11-19 | Composition for preventing or treating cavity and periodontal disease comprising Ambrosia trifida extract or its fraction as effective component |
Country Status (2)
| Country | Link |
|---|---|
| KR (1) | KR101625412B1 (en) |
| WO (1) | WO2016080666A2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102534818B1 (en) * | 2021-05-27 | 2023-05-26 | (주)아로마뉴텍 | Ambrosia trifida supercritical extract and its use |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2723173T3 (en) * | 2010-04-30 | 2019-08-22 | Allovate Llc | Toothpaste for allergic desensitization through the oral mucosa |
-
2014
- 2014-11-19 KR KR1020140161278A patent/KR101625412B1/en active IP Right Grant
-
2015
- 2015-10-23 WO PCT/KR2015/011243 patent/WO2016080666A2/en active Application Filing
Non-Patent Citations (2)
| Title |
|---|
| Molecules. 2006. Vol.11, pp.549-555 |
| 미생물학회지. 2007. 43(3), pp.227-231.* |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016080666A2 (en) | 2016-05-26 |
| WO2016080666A3 (en) | 2016-07-14 |
| KR20160059603A (en) | 2016-05-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6387467B2 (en) | Mangosteen extract or composition for preventing or ameliorating periodontal disease comprising alpha and gamma mangosteen as active ingredients | |
| KR101841181B1 (en) | Toothpaste composition comprising herval extract | |
| US20100129296A1 (en) | Extract of trigonella foenum-graecum | |
| KR101354923B1 (en) | Oral hygiene composition using an extract of curcuma longa and an extract eriobotrya japonica | |
| KR20190000955A (en) | Composition for preventing or treating periodontal disease comprising extracts of herbal mixture | |
| JP2007320926A (en) | Plaque formation inhibitor, or cariostatic agent | |
| KR101625412B1 (en) | Composition for preventing or treating cavity and periodontal disease comprising Ambrosia trifida extract or its fraction as effective component | |
| KR20140031512A (en) | Composition for treating oral disease and inhibiting halitosis comprising the extract of schizandra chinensis | |
| KR20170141034A (en) | Composition for prevention or treatment of dental disease comprising Panax ginseng extract | |
| KR101703269B1 (en) | Oral care composition comprising Magnolia officinalis extract and bicarbonate | |
| KR20200071360A (en) | Toothpaste Composition Comprising Rosa Canina Extract | |
| KR101561441B1 (en) | Composition for preventing or treating periodontal disease comprising Solanum carolinense extract as effective component | |
| KR101574678B1 (en) | Composition for preventing or treating periodontal disease comprising Lactuca scariola extract as effective component | |
| KR101634210B1 (en) | Composition for preventing or treating cavity and periodontal disease comprising kaempferol as effective component | |
| KR101627528B1 (en) | Composition for preventing or treating cavity and periodontal disease comprising Phytolacca americana extract or its fraction as effective component | |
| KR20160059606A (en) | Composition for preventing or treating cavity and periodontal disease comprising Robinia pseudoacacia extract or its fraction as effective component | |
| KR101685671B1 (en) | Pharmaceutical composition for preventing or treating peridontal disease comprising extract of Lignum Acronychiae containing nerolidol | |
| KR101574676B1 (en) | Composition for preventing or treating periodontal disease comprising Tragopogon dubius extract as effective component | |
| KR101630829B1 (en) | Composition for preventing or treating oral disease comprising Echinacoside | |
| KR101834758B1 (en) | Composition containing a bee venom for prevention or treating periodontal diseases | |
| KR20180046247A (en) | Composition for prevention or treatment of oral disease comprising Verbascoside | |
| Achmad et al. | Herbal Plants as a Treatment for Halitosis in Children: A Systematic Review | |
| KR20180046250A (en) | Composition for prevention or treatment of oral disease comprising Astilbin | |
| KR20180047705A (en) | Composition for prevention or treatment of oral disease comprising Forsythiae Fructus extract | |
| KR20180047704A (en) | Composition for prevention or treatment of oral disease comprising Scutellaria baicalensis extract |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| E701 | Decision to grant or registration of patent right | ||
| GRNT | Written decision to grant | ||
| FPAY | Annual fee payment |
Payment date: 20190502 Year of fee payment: 4 |