KR101606248B1 - 생물학적 활성 펩티드 - Google Patents

생물학적 활성 펩티드 Download PDF

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Publication number
KR101606248B1
KR101606248B1 KR1020137024826A KR20137024826A KR101606248B1 KR 101606248 B1 KR101606248 B1 KR 101606248B1 KR 1020137024826 A KR1020137024826 A KR 1020137024826A KR 20137024826 A KR20137024826 A KR 20137024826A KR 101606248 B1 KR101606248 B1 KR 101606248B1
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KR
South Korea
Prior art keywords
peptide
val trp
prt
artificial sequence
synthetic peptide
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020137024826A
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English (en)
Korean (ko)
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KR20130112959A (ko
Inventor
프레드리히 슈에이플린거
미쉘 독칼
Original Assignee
백스터 인터내셔널 인코포레이티드
박스터 헬쓰케어 에스에이
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Publication of KR20130112959A publication Critical patent/KR20130112959A/ko
Application granted granted Critical
Publication of KR101606248B1 publication Critical patent/KR101606248B1/ko
Assigned to 박스앨타 게엠베하, 박스알타 인코퍼레이티드 reassignment 박스앨타 게엠베하 권리의 전부이전등록 Assignors: 박스터 헬쓰케어 에스에이, 백스터 인터내셔널 인코포레이티드
Assigned to 다케다 야쿠힌 고교 가부시키가이샤 reassignment 다케다 야쿠힌 고교 가부시키가이샤 권리의 전부이전등록 Assignors: 박스알타 인코퍼레이티드, 박스앨타 게엠베하
Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
KR1020137024826A 2008-04-17 2009-04-16 생물학적 활성 펩티드 Expired - Fee Related KR101606248B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US932608P 2008-04-17 2008-04-17
US61/009,326 2008-04-17
US11305508P 2008-11-10 2008-11-10
US61/113,055 2008-11-10
PCT/US2009/040857 WO2009137256A1 (en) 2008-04-17 2009-04-16 Biologically active peptides

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020107025687A Division KR101434712B1 (ko) 2008-04-17 2009-04-16 생물학적 활성 펩티드

Publications (2)

Publication Number Publication Date
KR20130112959A KR20130112959A (ko) 2013-10-14
KR101606248B1 true KR101606248B1 (ko) 2016-03-24

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KR1020137024826A Expired - Fee Related KR101606248B1 (ko) 2008-04-17 2009-04-16 생물학적 활성 펩티드
KR1020107025687A Expired - Fee Related KR101434712B1 (ko) 2008-04-17 2009-04-16 생물학적 활성 펩티드

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Country Link
US (6) US8563688B2 (enExample)
EP (2) EP2279200B1 (enExample)
JP (3) JP6038452B2 (enExample)
KR (2) KR101606248B1 (enExample)
CN (2) CN102007140B (enExample)
AR (1) AR071478A1 (enExample)
AU (1) AU2009244635B2 (enExample)
BR (1) BRPI0911203A2 (enExample)
CA (1) CA2721694C (enExample)
DK (2) DK2279200T3 (enExample)
ES (2) ES2739676T3 (enExample)
HK (1) HK1223946A1 (enExample)
MX (1) MX2010011397A (enExample)
NZ (1) NZ588200A (enExample)
PL (1) PL2279200T3 (enExample)
PT (1) PT2279200T (enExample)
SG (2) SG10201809286XA (enExample)
TW (2) TWI573806B (enExample)
WO (1) WO2009137256A1 (enExample)

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AR071478A1 (es) * 2008-04-17 2010-06-23 Baxter Healthcare Sa Peptidos de bajo peso molecular con actividad procoagulante para el tratamiento de pacientes con deficiencia de factor v (fv), fvii, fviii, fx y/o fxi
CA2771999A1 (en) 2009-08-24 2011-03-10 Amunix Operating Inc. Coagulation factor vii compositions and methods of making and using same
WO2012012444A2 (en) 2010-07-19 2012-01-26 Dolby Laboratories Licensing Corporation Enhancement methods for sampled and multiplexed image and video data
CA2838833A1 (en) 2011-06-10 2012-12-13 Biogen Idec Ma Inc. Pro-coagulant compounds and methods of use thereof
CN111548418A (zh) 2012-02-15 2020-08-18 比奥贝拉蒂治疗公司 因子viii组合物及其制备和使用方法
WO2013123457A1 (en) 2012-02-15 2013-08-22 Biogen Idec Ma Inc. Recombinant factor viii proteins
BR112015028502B1 (pt) * 2013-06-11 2022-03-22 Cj Cheiljedang Corporation Microrganismo produtor de l-isoleucina e método para a produção de l-isoleucina utilizando o mesmo
US20160311885A1 (en) 2013-08-14 2016-10-27 Biogen Ma Inc. Recombinant factor viii proteins
US10548953B2 (en) 2013-08-14 2020-02-04 Bioverativ Therapeutics Inc. Factor VIII-XTEN fusions and uses thereof
WO2015070014A1 (en) 2013-11-08 2015-05-14 Biogen Idec Ma Inc. Procoagulant fusion compound
EA201691111A1 (ru) 2014-01-10 2017-01-30 Байоджен Ма Инк. Химерные белки фактора viii и их применение
US9321812B2 (en) 2014-03-28 2016-04-26 Perle Bioscience Insulin independence among patients with diabetes utilizing an optimized hamster REG3 gamma peptide
JP6484468B2 (ja) * 2014-06-03 2019-03-13 ＡｖａｎＳｔｒａｔｅ株式会社 ガラス板製造方法およびガラス板製造装置
GB201410507D0 (en) * 2014-06-12 2014-07-30 Univ Bath Drug delivery enhancement agents
UA126016C2 (uk) 2015-08-03 2022-08-03 Біовератів Терапеутікс Інк. Злитий білок фактора іх
EP3519431A1 (en) 2016-09-28 2019-08-07 Cohbar Inc. Therapeutic mots-c related peptides
KR20190090827A (ko) 2016-12-02 2019-08-02 바이오버라티브 테라퓨틱스 인크. 키메라 응고 인자를 사용해 혈우병성 관절증을 치료하는 방법
BR112019015569A2 (pt) 2017-01-31 2020-03-17 Bioverativ Therapeutics Inc. Proteínas de fusão do fator ix e métodos para a sua produção e uso
KR102914074B1 (ko) 2018-05-18 2026-01-16 바이오버라티브 테라퓨틱스 인크. A형 혈우병의 치료 방법

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Publication number Priority date Publication date Assignee Title
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Also Published As

Publication number Publication date
KR20130112959A (ko) 2013-10-14
US8822638B2 (en) 2014-09-02
ES2739676T3 (es) 2020-02-03
PL2279200T3 (pl) 2017-08-31
ES2594706T3 (es) 2016-12-22
TW200944226A (en) 2009-11-01
US20160060295A1 (en) 2016-03-03
AU2009244635A1 (en) 2009-11-12
US9598464B2 (en) 2017-03-21
JP2017019797A (ja) 2017-01-26
EP3115370A1 (en) 2017-01-11
SG10201608071YA (en) 2016-11-29
CN102007140A (zh) 2011-04-06
US10822376B2 (en) 2020-11-03
HK1223946A1 (zh) 2017-08-11
CN102007140B (zh) 2016-02-24
US20190225648A1 (en) 2019-07-25
KR101434712B1 (ko) 2014-10-01
SG10201809286XA (en) 2018-11-29
TW201443085A (zh) 2014-11-16
BRPI0911203A2 (pt) 2016-07-05
DK3115370T3 (da) 2019-07-29
US20120077749A1 (en) 2012-03-29
NZ588200A (en) 2012-11-30
TWI573806B (zh) 2017-03-11
JP6038452B2 (ja) 2016-12-07
US20170174724A1 (en) 2017-06-22
WO2009137256A1 (en) 2009-11-12
US20150038676A1 (en) 2015-02-05
AR071478A1 (es) 2010-06-23
JP5977223B2 (ja) 2016-08-24
CA2721694C (en) 2018-11-06
US9206234B2 (en) 2015-12-08
US10287319B2 (en) 2019-05-14
HK1154255A1 (zh) 2012-04-13
KR20110005873A (ko) 2011-01-19
PT2279200T (pt) 2016-10-12
JP2014074052A (ja) 2014-04-24
US8563688B2 (en) 2013-10-22
MX2010011397A (es) 2010-11-12
AU2009244635B2 (en) 2012-04-19
EP3115370B1 (en) 2019-06-26
EP2279200A1 (en) 2011-02-02
TWI541020B (zh) 2016-07-11
US20100022445A1 (en) 2010-01-28
CN105524163A (zh) 2016-04-27
EP2279200B1 (en) 2016-07-13
CA2721694A1 (en) 2009-11-12
DK2279200T3 (en) 2016-08-22
JP2011518179A (ja) 2011-06-23

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