KR101593360B1 - 브로모크립틴 제제 - Google Patents

브로모크립틴 제제 Download PDF

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Publication number
KR101593360B1
KR101593360B1 KR1020147033501A KR20147033501A KR101593360B1 KR 101593360 B1 KR101593360 B1 KR 101593360B1 KR 1020147033501 A KR1020147033501 A KR 1020147033501A KR 20147033501 A KR20147033501 A KR 20147033501A KR 101593360 B1 KR101593360 B1 KR 101593360B1
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South Korea
Prior art keywords
bromocriptine
mesylate
bromocriptine mesylate
tablet
particle size
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KR1020147033501A
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Korean (ko)
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KR20150006461A (ko
Inventor
안토니 신코타
크레이그 마이클 보웨
폴 클라크 스티언스
로라 진 웨스톤
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베로사이언스, 엘엘씨
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Inorganic Chemistry (AREA)
  • Psychology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020147033501A 2012-04-30 2013-04-29 브로모크립틴 제제 Active KR101593360B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/460,452 2012-04-30
US13/460,452 US8431155B1 (en) 2012-04-30 2012-04-30 Bromocriptine formulations
PCT/US2013/038655 WO2013165902A1 (en) 2012-04-30 2013-04-29 Bromocriptine formulations

Publications (2)

Publication Number Publication Date
KR20150006461A KR20150006461A (ko) 2015-01-16
KR101593360B1 true KR101593360B1 (ko) 2016-02-11

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US (11) US8431155B1 (enExample)
EP (4) EP4342536B1 (enExample)
JP (1) JP6180515B2 (enExample)
KR (1) KR101593360B1 (enExample)
AR (1) AR091351A1 (enExample)
AU (3) AU2013256558B2 (enExample)
BR (1) BR112014027087B1 (enExample)
CA (1) CA2872300C (enExample)
ES (3) ES2972198T3 (enExample)
MX (2) MX363670B (enExample)
UY (1) UY34776A (enExample)
WO (1) WO2013165902A1 (enExample)

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US20100035886A1 (en) 2007-06-21 2010-02-11 Veroscience, Llc Parenteral formulations of dopamine agonists
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US9352025B2 (en) 2009-06-05 2016-05-31 Veroscience Llc Combination of dopamine agonists plus first phase insulin secretagogues for the treatment of metabolic disorders
US8431155B1 (en) 2012-04-30 2013-04-30 Veroscience Llc Bromocriptine formulations
US9682096B2 (en) 2012-05-02 2017-06-20 Janssen R & D Ireland Polyinosinic-polycytidylic acid (poly (I:C)) formulations for the treatment of upper respiratory tract infections
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US10426772B2 (en) 2016-05-16 2019-10-01 Regents Of The University Of Minnesota Use of ergot alkaloids as an anthelmintic agent
HRP20241365T1 (hr) 2017-10-18 2024-12-20 Veroscience Llc Poboljšane formulacije bromokriptina
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US20160038424A1 (en) 2016-02-11
AR091351A1 (es) 2015-01-28
EP3620155A1 (en) 2020-03-11
AU2016202572B2 (en) 2018-02-01
AU2013256558A1 (en) 2014-12-18
BR112014027087A2 (pt) 2017-06-27
ES2755081T3 (es) 2020-04-21
EP4342536C0 (en) 2025-10-01
US11000522B2 (en) 2021-05-11
EP3620155B1 (en) 2021-10-20
HK1208173A1 (en) 2016-02-26
AU2013256558B2 (en) 2016-01-28
US20170020871A1 (en) 2017-01-26
AU2018203021B2 (en) 2020-02-06
ES2972198T3 (es) 2024-06-11
US20240131026A1 (en) 2024-04-25
EP3960160B1 (en) 2023-12-06
US20180263978A1 (en) 2018-09-20
KR20150006461A (ko) 2015-01-16
US8431155B1 (en) 2013-04-30
US20200276193A1 (en) 2020-09-03
MX363670B (es) 2019-03-29
MX2014013158A (es) 2015-07-14
US20190343833A1 (en) 2019-11-14
WO2013165902A1 (en) 2013-11-07
EP4342536B1 (en) 2025-10-01
US9993474B2 (en) 2018-06-12
AU2018203021A1 (en) 2018-05-24
US9700555B2 (en) 2017-07-11
US8613947B2 (en) 2013-12-24
UY34776A (es) 2013-11-29
ES2902573T3 (es) 2022-03-29
US20170340632A1 (en) 2017-11-30
EP4342536A2 (en) 2024-03-27
AU2016202572A1 (en) 2016-05-19
US20130287848A1 (en) 2013-10-31
US20140187560A1 (en) 2014-07-03
JP2015515984A (ja) 2015-06-04
BR112014027087B1 (pt) 2021-03-02
EP2844229B1 (en) 2019-09-11
US20210228576A1 (en) 2021-07-29
EP4342536A3 (en) 2024-06-26
MX2019003619A (es) 2019-07-18
US9192576B2 (en) 2015-11-24
US11666567B2 (en) 2023-06-06
CA2872300A1 (en) 2013-11-07
US9522117B2 (en) 2016-12-20
US10307421B2 (en) 2019-06-04
JP6180515B2 (ja) 2017-08-16
EP3960160A1 (en) 2022-03-02
EP2844229A1 (en) 2015-03-11
US10688094B2 (en) 2020-06-23
CA2872300C (en) 2016-08-16

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