KR101523257B1 - 니트로-이미다졸 저산소증 영상화제 - Google Patents

니트로-이미다졸 저산소증 영상화제 Download PDF

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KR101523257B1
KR101523257B1 KR1020097023183A KR20097023183A KR101523257B1 KR 101523257 B1 KR101523257 B1 KR 101523257B1 KR 1020097023183 A KR1020097023183 A KR 1020097023183A KR 20097023183 A KR20097023183 A KR 20097023183A KR 101523257 B1 KR101523257 B1 KR 101523257B1
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compound
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formula
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KR20090130106A (ko
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하르트무트 씨 콜브
조셉 씨. 월쉬
우메쉬 비. 간가다르마트
파르하트 카리미
헨리 클립튼 패드겟
다나라크쉬미 카시
지용 가오
퀴안와 리앙
토마스 리 콜리어
브라이언 에이. 듀클로스
티에밍 차오
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쓰레솔드 파마슈티컬스, 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020097023183A 2007-04-05 2008-04-04 니트로-이미다졸 저산소증 영상화제 Expired - Fee Related KR101523257B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US92193207P 2007-04-05 2007-04-05
US60/921,932 2007-04-05
US96425407P 2007-08-10 2007-08-10
US60/964,254 2007-08-10
PCT/US2008/059505 WO2008124651A2 (en) 2007-04-05 2008-04-04 Nitro-imidazole hypoxia imaging agents

Publications (2)

Publication Number Publication Date
KR20090130106A KR20090130106A (ko) 2009-12-17
KR101523257B1 true KR101523257B1 (ko) 2015-05-27

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KR1020097023183A Expired - Fee Related KR101523257B1 (ko) 2007-04-05 2008-04-04 니트로-이미다졸 저산소증 영상화제

Country Status (7)

Country Link
US (2) US7807394B2 (enExample)
EP (1) EP2132200B1 (enExample)
JP (1) JP5347164B2 (enExample)
KR (1) KR101523257B1 (enExample)
CN (1) CN101652360B (enExample)
CA (1) CA2683433C (enExample)
WO (1) WO2008124651A2 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2683433C (en) * 2007-04-05 2016-10-11 Siemens Medical Solutions Usa, Inc. Nitro-imidazole hypoxia imaging agents
CN101709060B (zh) * 2009-12-02 2013-05-01 北京师范大学 一种f-三唑环-聚乙二醇-甲硝唑化合物及其制备方法
KR101709372B1 (ko) 2010-02-08 2017-02-22 랜티우스 메디컬 이메징, 인크. 조영제 및 이의 중간체를 합성하는 방법 및 장치
US10639608B2 (en) 2010-04-08 2020-05-05 Siemens Medical Solutions Usa, Inc. System, device and method for preparing tracers and transferring materials during radiosynthesis
EP2556372A1 (en) 2010-04-08 2013-02-13 Siemens Medical Solutions USA, Inc. Synthesis of 18f-labeled tracers in hydrous organic solvents
CN101921263A (zh) * 2010-04-16 2010-12-22 兰州大学 2-硝基咪唑衍生物及其用途和制备方法
KR20170042373A (ko) 2010-05-11 2017-04-18 랜티우스 메디컬 이메징, 인크. 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템
EP3567029A1 (en) 2011-09-09 2019-11-13 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
CN103945901A (zh) 2011-10-14 2014-07-23 住友重机械工业株式会社 带电粒子束照射系统以及带电粒子束照射计划方法
EP2793871A4 (en) * 2011-12-23 2015-07-22 Auckland Uniservices Ltd COMPOUNDS AND METHODS FOR SELECTIVE IMAGING AND / OR ABLATION
WO2014062856A1 (en) 2012-10-16 2014-04-24 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
RU2635557C2 (ru) 2014-01-13 2017-11-14 Хафид БЕЛХАДЖ-ТАХАР Дендримерные композиции, способы их синтеза и их применение
WO2016047424A1 (ja) * 2014-09-25 2016-03-31 日本メジフィジックス株式会社 腎イメージング剤
US10695446B2 (en) 2015-05-01 2020-06-30 Vanderbilt University Composition and method for detecting hypoxia
US10695450B2 (en) 2016-07-26 2020-06-30 Laboratoires Cyclopharma Synthesis of a radioactive agent composition
CN106977501A (zh) * 2017-03-20 2017-07-25 华东师范大学 一种基于2‑硝基咪唑‑1‑烷基醇的低氧激活前药
FR3068695B1 (fr) * 2017-07-05 2019-08-16 Centre National De La Recherche Scientifique Composes utiles comme agent d'imagerie de l'hypoxie
CN111372940A (zh) * 2017-09-19 2020-07-03 阿尔伯塔大学理事会 生物还原活化的化合物、其前药、放射性药物、组合物及其在包括癌症在内的低氧疾病的多模式治疗控制中的应用
CN111356698B (zh) * 2017-09-19 2025-02-25 威奇生物科技公司 用于低氧成像、映射和治疗的标记物、缀合物、组合物和方法
US11091447B2 (en) 2020-01-03 2021-08-17 Berg Llc UBE2K modulators and methods for their use
CN111233821B (zh) * 2020-01-20 2022-12-27 上海交通大学医学院附属仁济医院 含3-羟基苯甲酸基团的新抗霉素衍生物及其制备方法和应用
CN114478489B (zh) * 2022-01-18 2023-04-28 中国科学院精密测量科学与技术创新研究院 一种氟-19修饰的硝基咪唑化合物及其衍生物的制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996004249A1 (en) * 1994-08-05 1996-02-15 Sri International Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells
US5674693A (en) * 1994-03-18 1997-10-07 Natural Pharmacia International Inc. Derivatives of 2-nitro-imidazoles as hypoxic cell markers
WO2001012575A1 (en) * 1999-08-11 2001-02-22 Universite Catholique De Louvain Methods for preparing perfluorinated [18f]-radiolabelled nitroimidazole derivatives for cellular hypoxia detection

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2683433C (en) * 2007-04-05 2016-10-11 Siemens Medical Solutions Usa, Inc. Nitro-imidazole hypoxia imaging agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5674693A (en) * 1994-03-18 1997-10-07 Natural Pharmacia International Inc. Derivatives of 2-nitro-imidazoles as hypoxic cell markers
WO1996004249A1 (en) * 1994-08-05 1996-02-15 Sri International Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells
WO2001012575A1 (en) * 1999-08-11 2001-02-22 Universite Catholique De Louvain Methods for preparing perfluorinated [18f]-radiolabelled nitroimidazole derivatives for cellular hypoxia detection

Also Published As

Publication number Publication date
EP2132200A2 (en) 2009-12-16
US7977361B2 (en) 2011-07-12
CA2683433A1 (en) 2008-10-16
EP2132200B1 (en) 2016-03-23
US20090010846A1 (en) 2009-01-08
CN101652360B (zh) 2014-06-25
JP2010523596A (ja) 2010-07-15
WO2008124651A2 (en) 2008-10-16
US7807394B2 (en) 2010-10-05
WO2008124651A3 (en) 2009-04-02
JP5347164B2 (ja) 2013-11-20
KR20090130106A (ko) 2009-12-17
CA2683433C (en) 2016-10-11
CN101652360A (zh) 2010-02-17
US20110002850A1 (en) 2011-01-06

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