CN101652360B - 硝基咪唑低氧造影剂 - Google Patents

硝基咪唑低氧造影剂 Download PDF

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Publication number
CN101652360B
CN101652360B CN200880011415.1A CN200880011415A CN101652360B CN 101652360 B CN101652360 B CN 101652360B CN 200880011415 A CN200880011415 A CN 200880011415A CN 101652360 B CN101652360 B CN 101652360B
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alkyl
compound
alkylidene group
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group
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Expired - Fee Related
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CN200880011415.1A
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English (en)
Chinese (zh)
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CN101652360A (zh
Inventor
H·C·科尔布
J·C·沃尔什
U·B·甘加达马斯
F·卡里米
H·C·帕吉特
D·卡西
高志勇
梁千瓦
T·L·科利耶
B·A·杜克洛斯
赵铁铭
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Siemens Molecular Imaging Ltd
Molecular Templates Inc
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Siemens Medical Solutions USA Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN200880011415.1A 2007-04-05 2008-04-04 硝基咪唑低氧造影剂 Expired - Fee Related CN101652360B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US92193207P 2007-04-05 2007-04-05
US60/921,932 2007-04-05
US96425407P 2007-08-10 2007-08-10
US60/964,254 2007-08-10
PCT/US2008/059505 WO2008124651A2 (en) 2007-04-05 2008-04-04 Nitro-imidazole hypoxia imaging agents

Publications (2)

Publication Number Publication Date
CN101652360A CN101652360A (zh) 2010-02-17
CN101652360B true CN101652360B (zh) 2014-06-25

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CN200880011415.1A Expired - Fee Related CN101652360B (zh) 2007-04-05 2008-04-04 硝基咪唑低氧造影剂

Country Status (7)

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US (2) US7807394B2 (enExample)
EP (1) EP2132200B1 (enExample)
JP (1) JP5347164B2 (enExample)
KR (1) KR101523257B1 (enExample)
CN (1) CN101652360B (enExample)
CA (1) CA2683433C (enExample)
WO (1) WO2008124651A2 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2132200B1 (en) * 2007-04-05 2016-03-23 Threshold Pharmaceuticals, Inc. Nitro-imidazole hypoxia imaging agents
CN101709060B (zh) * 2009-12-02 2013-05-01 北京师范大学 一种f-三唑环-聚乙二醇-甲硝唑化合物及其制备方法
PT3323810T (pt) 2010-02-08 2022-04-14 Lantheus Medical Imaging Inc Sistema de reação automatizado, cassete e dispositivo para sintetizar agentes de imagem
JP6245981B2 (ja) 2010-04-08 2017-12-13 シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッドＳｉｅｍｅｎｓ Ｍｅｄｉｃａｌ Ｓｏｌｕｔｉｏｎｓ ＵＳＡ，Ｉｎｃ． 含水有機溶媒中の１８ｆ−標識化トレーサーの合成
US10639608B2 (en) 2010-04-08 2020-05-05 Siemens Medical Solutions Usa, Inc. System, device and method for preparing tracers and transferring materials during radiosynthesis
CN101921263A (zh) * 2010-04-16 2010-12-22 兰州大学 2-硝基咪唑衍生物及其用途和制备方法
EP3653230B1 (en) 2010-05-11 2023-05-10 Lantheus Medical Imaging, Inc. Compositions, methods and systems for the synthesis and use of imaging agents
SG10201607437QA (en) 2011-09-09 2016-10-28 Lantheus Medical Imaging Inc Compositions, methods, and systems for the synthesis and use of imaging agents
CN103945901A (zh) 2011-10-14 2014-07-23 住友重机械工业株式会社 带电粒子束照射系统以及带电粒子束照射计划方法
US20150010474A1 (en) * 2011-12-23 2015-01-08 Auckland Uniservices Limited Compounds And Methods For Selective Imaging And/Or Ablation
WO2014062856A1 (en) 2012-10-16 2014-04-24 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
US9603953B2 (en) 2014-01-13 2017-03-28 Guanghua YANG Dendrimer compositions, methods of synthesis, and uses thereof
CA2959776A1 (en) * 2014-09-25 2016-03-31 Nihon Medi-Physics Co., Ltd. Renal imaging agent
WO2016179117A1 (en) * 2015-05-01 2016-11-10 Vanderbilt University Composition and method for detecting hypoxia
US10695450B2 (en) 2016-07-26 2020-06-30 Laboratoires Cyclopharma Synthesis of a radioactive agent composition
CN106977501A (zh) * 2017-03-20 2017-07-25 华东师范大学 一种基于2‑硝基咪唑‑1‑烷基醇的低氧激活前药
FR3068695B1 (fr) 2017-07-05 2019-08-16 Centre National De La Recherche Scientifique Composes utiles comme agent d'imagerie de l'hypoxie
US20200216486A1 (en) * 2017-09-19 2020-07-09 The Governors Of The University Of Alberta Markers, conjugates, compositions and methods for hypoxia imaging, mapping, and therapy
WO2019056098A1 (en) * 2017-09-19 2019-03-28 The Governors Of The University Of Alberta BIOREDUCTION-ACTIVATED COMPOUNDS, THEIR PRODRUGS, RADIOPHARMACEUTICAL PRODUCTS, COMPOSITIONS AND THEIR APPLICATIONS IN THE MULTIMODAL THERANOSTIC MANAGEMENT OF HYPOXIA, INCLUDING CANCER
CA3166630A1 (en) 2020-01-03 2021-07-08 Berg Llc Polycyclic amides as ube2k modulators for treating cancer
CN111233821B (zh) * 2020-01-20 2022-12-27 上海交通大学医学院附属仁济医院 含3-羟基苯甲酸基团的新抗霉素衍生物及其制备方法和应用
CN114478489B (zh) * 2022-01-18 2023-04-28 中国科学院精密测量科学与技术创新研究院 一种氟-19修饰的硝基咪唑化合物及其衍生物的制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996004249A1 (en) * 1994-08-05 1996-02-15 Sri International Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells
US5674693A (en) * 1994-03-18 1997-10-07 Natural Pharmacia International Inc. Derivatives of 2-nitro-imidazoles as hypoxic cell markers
WO2001012575A1 (en) * 1999-08-11 2001-02-22 Universite Catholique De Louvain Methods for preparing perfluorinated [18f]-radiolabelled nitroimidazole derivatives for cellular hypoxia detection

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2132200B1 (en) * 2007-04-05 2016-03-23 Threshold Pharmaceuticals, Inc. Nitro-imidazole hypoxia imaging agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5674693A (en) * 1994-03-18 1997-10-07 Natural Pharmacia International Inc. Derivatives of 2-nitro-imidazoles as hypoxic cell markers
WO1996004249A1 (en) * 1994-08-05 1996-02-15 Sri International Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells
WO2001012575A1 (en) * 1999-08-11 2001-02-22 Universite Catholique De Louvain Methods for preparing perfluorinated [18f]-radiolabelled nitroimidazole derivatives for cellular hypoxia detection

Also Published As

Publication number Publication date
CA2683433C (en) 2016-10-11
US7807394B2 (en) 2010-10-05
KR101523257B1 (ko) 2015-05-27
WO2008124651A3 (en) 2009-04-02
US20090010846A1 (en) 2009-01-08
US7977361B2 (en) 2011-07-12
JP5347164B2 (ja) 2013-11-20
WO2008124651A2 (en) 2008-10-16
EP2132200A2 (en) 2009-12-16
JP2010523596A (ja) 2010-07-15
CN101652360A (zh) 2010-02-17
CA2683433A1 (en) 2008-10-16
US20110002850A1 (en) 2011-01-06
KR20090130106A (ko) 2009-12-17
EP2132200B1 (en) 2016-03-23

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