KR101475528B1 - 분자 각인 폴리머의 개선된 제조법 - Google Patents

분자 각인 폴리머의 개선된 제조법 Download PDF

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KR101475528B1
KR101475528B1 KR1020087022727A KR20087022727A KR101475528B1 KR 101475528 B1 KR101475528 B1 KR 101475528B1 KR 1020087022727 A KR1020087022727 A KR 1020087022727A KR 20087022727 A KR20087022727 A KR 20087022727A KR 101475528 B1 KR101475528 B1 KR 101475528B1
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mips
mip
particles
template
polymers
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KR20080096834A (ko
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제스퍼 스베닝 크리스텐센
클라우스 그레고리우스 닐센
니콜라스 오토 크로그
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미프살러스 에이피에스
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/268—Polymers created by use of a template, e.g. molecularly imprinted polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/305—Addition of material, later completely removed, e.g. as result of heat treatment, leaching or washing, e.g. for forming pores
    • B01J20/3057—Use of a templating or imprinting material ; filling pores of a substrate or matrix followed by the removal of the substrate or matrix
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Thermal Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Materials Engineering (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Peptides Or Proteins (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020087022727A 2006-02-21 2008-09-17 분자 각인 폴리머의 개선된 제조법 Expired - Fee Related KR101475528B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US74333006P 2006-02-21 2006-02-21
DKPA200600248 2006-02-21
DKPA200600248 2006-02-21
US60/743,330 2006-02-21
PCT/DK2007/000083 WO2007095949A2 (en) 2006-02-21 2007-02-21 Improved preparation of molecular imprinted polymers

Publications (2)

Publication Number Publication Date
KR20080096834A KR20080096834A (ko) 2008-11-03
KR101475528B1 true KR101475528B1 (ko) 2014-12-22

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Country Status (11)

Country Link
US (1) US8287908B2 (https=)
EP (1) EP1988993B1 (https=)
JP (1) JP2009527471A (https=)
KR (1) KR101475528B1 (https=)
AU (1) AU2007218396C1 (https=)
CA (1) CA2642097C (https=)
DK (1) DK1988993T3 (https=)
ES (1) ES2736148T3 (https=)
IL (1) IL193416A (https=)
RU (1) RU2437665C2 (https=)
WO (1) WO2007095949A2 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201200878D0 (en) * 2012-01-19 2012-02-29 British American Tobacco Co Polymer compositions
EP2477706B1 (en) * 2009-09-16 2020-12-23 Mipsalus Aps Molecular imprinted polymers for use in a treatment of a disease
CN101942062B (zh) * 2010-08-09 2013-07-17 南开大学 一种用于催化有机磷农药降解的表面印迹聚合物及制备方法
WO2012031128A2 (en) * 2010-09-01 2012-03-08 The Research Foundation Of State University Of New York Microorganism imprinted polymers with integrated emission sites, and methods of making and using same
US9084727B2 (en) * 2011-05-10 2015-07-21 Bend Research, Inc. Methods and compositions for maintaining active agents in intra-articular spaces
CA2864908C (en) 2012-02-28 2021-01-12 Mipsalus Aps Preparation of molecular imprinted polymers by cross-linking
US9557250B2 (en) 2012-05-17 2017-01-31 The Board Of Trustees Of The Leland Stanford Junior University Devices and methods for separating particles
RU2515455C2 (ru) * 2012-07-29 2014-05-10 Закрытое Акционерное Общество "Аксион-Редкие И Драгоценные Металлы" Способ получения адаптивно-селективного к редкоземельным металлам ионообменного материала
US11051529B2 (en) 2015-01-13 2021-07-06 The Decaf Company, Llc Programmable polymer caffeine extraction
US20170172946A1 (en) * 2015-12-21 2017-06-22 Stephan Hau Micro-solid phase extraction
WO2017157980A1 (en) 2016-03-15 2017-09-21 Mipsalus Aps Detection method and means therefor
AT518590A3 (de) * 2016-04-29 2022-09-15 Mosbach Klaus Speicherung von binärkodes in molekular geprägten polymeren
CA3067123A1 (en) 2017-06-29 2019-01-03 Mipsalus Aps Molecular imprinted polymers targeting phenylalanine
CN111151227A (zh) * 2019-10-21 2020-05-15 深圳市易瑞生物技术股份有限公司 半分子印迹材料及其制备方法和应用
US10828322B1 (en) 2019-11-29 2020-11-10 Claves Life Sciences Limited Molecularly imprinted polymers for sequestering acetate and other molecules
RU2765188C1 (ru) * 2020-11-03 2022-01-26 Федеральное государственное бюджетное образовательное учреждение высшего образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации Способ получения селективного сорбента для твердофазной экстракции
CN113231034A (zh) * 2021-04-21 2021-08-10 华南师范大学 一种dgt结合相及其制备方法和应用
WO2025153614A1 (en) 2024-01-16 2025-07-24 Mipsalus Aps Cross-linked polymers and their use in methods of binding cations

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003147025A (ja) * 2001-04-05 2003-05-21 Sekisui Chem Co Ltd 胆汁酸特異的認識ポリマー及びコレステロール低下剤

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03147025A (ja) 1989-11-01 1991-06-24 Mitsubishi Electric Corp ベーシックインタプリタ
SE9203435D0 (sv) * 1992-11-11 1992-11-11 Georg Vlatakis Fondation For R Framstaellande av artificiella antikroppar med molekylavtrycksmetoden samt deras anvaendning vid analys
WO1994019693A1 (en) * 1993-02-24 1994-09-01 Baxter Diagnostics Inc. Immobilization of specific binding assay reagents
US5994110A (en) * 1995-02-10 1999-11-30 Mosbach; Klaus Methods for direct synthesis of compounds having complementary structure to a desired molecular entity and use thereof
JPH11507402A (ja) * 1995-05-26 1999-06-29 アイジェン・インコーポレーテッド 分子的にインプリントされた粒状ポリマー及び同ポリマーのペルフロオロカーボン液中における安定化懸濁重合
US5786428A (en) * 1996-03-27 1998-07-28 California Institute Of Technology Adsorbents for amino acid and peptide separation
SE9802092D0 (sv) * 1998-06-12 1998-06-12 Boerje Sellergren Selective adsorbent
SE9900121D0 (sv) * 1999-01-14 1999-01-14 Klaus Mosbach Molecularly imprinted microspheres prepared using precipitation polymerization
US6217901B1 (en) 1999-05-25 2001-04-17 Alnis, Llc Liposome-assisted synthesis of polymeric nanoparticles
GB9925056D0 (en) * 1999-10-23 1999-12-22 Univ Cranfield Preparation of biologically-active molecules by template polymerization
SE9903958D0 (sv) * 1999-11-02 1999-11-02 Boerje Sellergren Porous materials for selective binding or transport of molecular guests
US6379599B1 (en) * 2000-01-10 2002-04-30 Council Of Scientific And Industrial Research Process for the preparation of molecularly imprinted polymers useful for separation of enzymes
US6458599B1 (en) * 2000-02-18 2002-10-01 Aspira Biosystems, Inc. Compositions and methods for capturing, isolating, detecting, analyzing and quantifying macromolecules
US6638498B2 (en) 2000-06-30 2003-10-28 Semorex Inc. Molecularly imprinted polymers for the treatment and diagnosis of medical conditions
US6660176B2 (en) * 2001-01-24 2003-12-09 Virginia Commonwealth University Molecular imprinting of small particles, and production of small particles from solid state reactants
SE0100631D0 (sv) * 2001-02-26 2001-02-26 Klaus Mosbach Molecularly imprinted scintillation polymers
WO2002084292A1 (en) * 2001-04-11 2002-10-24 Aspira Biosystems, Inc. Inverse emulsion methods of making polymeric imprint beads
JP2003147205A (ja) * 2001-11-15 2003-05-21 Kanegafuchi Chem Ind Co Ltd 光学材料用硬化性組成物、光学用材料、光学用材料の製造方法および光学材料を用いた発光ダイオード
WO2003101580A1 (en) * 2002-05-31 2003-12-11 Austria Wirtschaftsservice Gesellschaft mit beschränkter Haftung Solid mycoctoxin carriers
GB0511116D0 (en) * 2005-06-01 2005-07-06 Univ Cranfield Preparation of soluble and collodial imprinted polymers by living polymerization

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003147025A (ja) * 2001-04-05 2003-05-21 Sekisui Chem Co Ltd 胆汁酸特異的認識ポリマー及びコレステロール低下剤

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DK1988993T3 (da) 2019-07-01
CA2642097C (en) 2016-08-02
US20090104277A1 (en) 2009-04-23
AU2007218396C1 (en) 2013-01-17
IL193416A0 (en) 2009-05-04
RU2437665C2 (ru) 2011-12-27
AU2007218396A1 (en) 2007-08-30
RU2008134011A (ru) 2010-03-27
ES2736148T3 (es) 2019-12-26
WO2007095949A2 (en) 2007-08-30
US8287908B2 (en) 2012-10-16
IL193416A (en) 2013-02-28
EP1988993B1 (en) 2019-04-17
JP2009527471A (ja) 2009-07-30
KR20080096834A (ko) 2008-11-03
AU2007218396B2 (en) 2011-07-28
WO2007095949A3 (en) 2008-01-10
EP1988993A2 (en) 2008-11-12
CA2642097A1 (en) 2007-08-30

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