KR101468216B1 - α,α,α-트리플루오로티미딘과 티미딘포스포릴라아제저해제를 배합한 항암제 - Google Patents

α,α,α-트리플루오로티미딘과 티미딘포스포릴라아제저해제를 배합한 항암제 Download PDF

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KR101468216B1
KR101468216B1 KR1020077016492A KR20077016492A KR101468216B1 KR 101468216 B1 KR101468216 B1 KR 101468216B1 KR 1020077016492 A KR1020077016492 A KR 1020077016492A KR 20077016492 A KR20077016492 A KR 20077016492A KR 101468216 B1 KR101468216 B1 KR 101468216B1
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alpha
ftd
day
cancer
administration
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KR20070104559A (ko
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도모히로 에무라
아키라 미타
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다이호야쿠힌고교 가부시키가이샤
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Priority claimed from US11/042,059 external-priority patent/US7799783B2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020077016492A 2005-01-26 2007-07-19 α,α,α-트리플루오로티미딘과 티미딘포스포릴라아제저해제를 배합한 항암제 Expired - Lifetime KR101468216B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11/042,059 2005-01-26
US11/042,059 US7799783B2 (en) 2005-01-26 2005-01-26 Method of administrating an anticancer drug containing α, α, α-trifluorothymidine and thymidine phosphorylase inhibitor
JPJP-P-2005-00165156 2005-06-06
JP2005165156 2005-06-06

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KR20070104559A KR20070104559A (ko) 2007-10-26
KR101468216B1 true KR101468216B1 (ko) 2014-12-03

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JP (1) JP5576591B2 (https=)
KR (1) KR101468216B1 (https=)
AU (1) AU2006209547C1 (https=)
BE (1) BE2017C028I2 (https=)
CA (1) CA2594713A1 (https=)
CY (2) CY2017029I2 (https=)
DK (1) DK1849470T4 (https=)
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FI (1) FI1849470T4 (https=)
FR (1) FR17C1028I2 (https=)
HU (2) HUE033306T2 (https=)
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NL (1) NL300889I2 (https=)
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SI (1) SI1849470T2 (https=)
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WO (1) WO2006080327A1 (https=)

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JP5576591B2 (ja) 2005-01-26 2014-08-20 大鵬薬品工業株式会社 α，α，α−トリフルオロチミジンとチミジンホスホリラーゼ阻害剤とを配合した抗癌剤
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
US8536188B2 (en) * 2007-04-25 2013-09-17 Cyclacel Limited Dosing regimens for treatment of proliferative disorders comprising administration of sapacitabine
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JP2011520845A (ja) * 2008-05-15 2011-07-21 カソリック ユニヴェルシテイト ルーヴェン，ケー．ユー． ルーヴェン アール アンド ディー 抗癌剤の組合せによる治療
KR101738369B1 (ko) 2009-07-22 2017-05-22 그뤼넨탈 게엠베하 핫 멜트 압출된 제어 방출 투여형
CN102639118B (zh) 2009-07-22 2015-07-29 格吕伦塔尔有限公司 氧化稳定的抗干扰剂型
BR112013005194A2 (pt) 2010-09-02 2016-05-03 Gruenenthal Gmbh forma de dosagem resistente à violação compreendendo sal inorgânico
TWI516286B (zh) 2010-09-02 2016-01-11 歌林達股份有限公司 含陰離子聚合物之抗破碎劑型
EA201400172A1 (ru) 2011-07-29 2014-06-30 Грюненталь Гмбх Устойчивая к разрушению таблетка, которая обеспечивает немедленное высвобождение лекарственного средства
BR112014001091A2 (pt) 2011-07-29 2017-02-14 Gruenenthal Gmbh comprimido resistente à adulteração que fornece liberação imediata do fármaco
US9371380B2 (en) 2011-08-16 2016-06-21 Taiho Pharmaceutical Co., Ltd. Antitumor agent and therapeutic effect prediction method for patients with KRAS-mutated colorectal cancer
TWI503122B (zh) * 2012-02-15 2015-10-11 Taiho Pharmaceutical Co Ltd Oral administration of pharmaceutical compositions
TWI526210B (zh) * 2012-02-15 2016-03-21 Taiho Pharmaceutical Co Ltd Oral pharmaceutical composition
MX356421B (es) 2012-02-28 2018-05-29 Gruenenthal Gmbh Forma de dosificacion resistente a la manipulacion indebida que comprende un compuesto farmacologicamente activo y un polimero anionico.
EP2838512B1 (en) 2012-04-18 2018-08-22 Grünenthal GmbH Tamper resistant and dose-dumping resistant pharmaceutical dosage form
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
WO2013173283A1 (en) 2012-05-16 2013-11-21 Novartis Ag Dosage regimen for a pi-3 kinase inhibitor
JP6002835B2 (ja) * 2013-03-27 2016-10-05 大鵬薬品工業株式会社 低用量イリノテカン塩酸塩水和物を含有する抗腫瘍剤
KR101847252B1 (ko) * 2013-03-27 2018-04-09 다이호야쿠힌고교 가부시키가이샤 이리노테칸염산염 수화물을 함유하는 항종양제
AU2014266278B2 (en) * 2013-05-17 2017-07-13 Taiho Pharmaceutical Co., Ltd. Therapeutic effect prediction method for colorectal cancer patient in whom expression of TK1 protein has increased
EP3003279A1 (en) 2013-05-29 2016-04-13 Grünenthal GmbH Tamper-resistant dosage form containing one or more particles
US9737490B2 (en) 2013-05-29 2017-08-22 Grünenthal GmbH Tamper resistant dosage form with bimodal release profile
BR112016000194A8 (pt) 2013-07-12 2019-12-31 Gruenenthal Gmbh forma de dosagem resistente à violação contendo o polímero de acetato de etileno-vinila
HRP20230523T1 (hr) 2013-09-06 2023-08-04 Taiho Pharmaceutical Co., Ltd. Antitumorski agens i sredstvo za poboljšavanje antitumorskog efekta
EP3073994A1 (en) 2013-11-26 2016-10-05 Grünenthal GmbH Preparation of a powdery pharmaceutical composition by means of cryo-milling
WO2015173195A1 (en) 2014-05-12 2015-11-19 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
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WO2016170097A1 (en) 2015-04-24 2016-10-27 Grünenthal GmbH Tamper-resistant dosage form with immediate release and resistance against solvent extraction
JP2018526414A (ja) 2015-09-10 2018-09-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護
WO2017119484A1 (ja) * 2016-01-08 2017-07-13 大鵬薬品工業株式会社 免疫調節剤を含有する抗腫瘍剤及び抗腫瘍効果増強剤
MA43977A (fr) 2016-02-05 2018-12-12 Taiho Pharmaceutical Co Ltd Méthode de traitement de patients atteints de cancer souffrant d'insuffisance rénale grave
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WO2019135405A1 (ja) 2018-01-05 2019-07-11 大鵬薬品工業株式会社 トリフルリジン由来の類縁物質の検出方法
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LUC00036I2 (https=) 2017-12-01
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ES2630002T3 (es) 2017-08-17
ES2630002T5 (es) 2024-09-19
PL1849470T5 (pl) 2024-06-10
JP5576591B2 (ja) 2014-08-20
SI1849470T1 (sl) 2017-10-30
CY2017029I1 (el) 2018-02-14
FR17C1028I1 (https=) 2017-09-29
LUC00036I1 (https=) 2017-10-02
DK1849470T4 (en) 2024-04-02
CY1119393T1 (el) 2018-02-14
PL1849470T3 (pl) 2017-11-30
AU2006209547B2 (en) 2011-05-26
DK1849470T3 (en) 2017-08-14
KR20070104559A (ko) 2007-10-26
NL300889I2 (nl) 2018-01-16
FI1849470T4 (fi) 2024-03-22
TW200637562A (en) 2006-11-01
LTPA2017024I1 (lt) 2017-08-10
CY2017029I2 (el) 2018-02-14
HUE033306T2 (hu) 2017-11-28
EP1849470B1 (en) 2017-06-21
LTC1849470I2 (lt) 2019-10-25
FR17C1028I2 (fr) 2018-11-02
EP1849470B2 (en) 2024-03-20
HUS1700032I1 (hu) 2017-09-28
PT1849470T (pt) 2017-09-22
AU2006209547C1 (en) 2022-04-07
WO2006080327A1 (ja) 2006-08-03
BE2017C028I2 (https=) 2025-09-10
TWI362265B (en) 2012-04-21
JPWO2006080327A1 (ja) 2008-06-19
EP1849470A4 (en) 2010-12-08
EP1849470A1 (en) 2007-10-31
SI1849470T2 (sl) 2024-05-31
CA2594713A1 (en) 2006-08-03
AU2006209547A1 (en) 2006-08-03
LT1849470T (lt) 2017-07-25
RU2007132181A (ru) 2009-03-10

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