KR101462367B1 - Alcohol-Free Red Ginseng Tablet - Google Patents

Abstract

The present invention relates to an alcohol-free red ginseng tablet and a method for preparing the same. The method for preparing the red ginseng tablet of the present invention does not use alcohol, but water, and thus alcohol does not included in a final product. Therefore, the present invention can be useful in a food market targeting Muslims in Arab world.

Description

Alcohol-Free Red Ginseng Tablet < RTI ID = 0.0 >

The present invention relates to a red ginseng tablet without alcohol.

Panax Ginseng is a herbal medicine in ginseng and ginseng, and red ginseng is produced by steam - drying ginseng roots. Ginseng contains amino acids, vitamins, organic acids, carbohydrates and various minerals. It is known as a medicinal herb that is effective in preventing and treating various diseases such as tonic action, thirst relief, strengthening of immune function, blood pressure, diabetes and fatigue recovery.

Various functional foods utilizing ginseng have been developed. Examples of such foods include red ginseng coffee tea disclosed in Patent Document 1 (registered patent No. 10-0043915), Patent Document 2 (Patent Application No. 10-1999-0034103), and patent And green tea containing concentrated ginseng and red ginseng in Document 3 (registered patent No. 10-0384902). In addition, a health supplement containing red ginseng as a raw material is disclosed in Patent Document 4 (Patent Application No. 10-2002-0020388), and Patent Document 5 (Patent Application No. 10-2011-0126487) Is disclosed.

In addition, red ginseng tablets containing red ginseng are also being manufactured, and a solvent mixed with alcohol is used in the preparation of tabret dosage forms. Alcohols used in the production of tablets are mixed with the solid of the powder in an insoluble state, and because of the diffusion nature of the alcohol, the alcohol quickly spreads on the surface of the powder, so that wetting conditions are formed and compression and tableting are facilitated.

Halal, on the other hand, is an Arabic word meaning 'acceptable', meaning that it can be consumed by Muslims, Muslims, and prohibits the use of pork, animal blood, dead meat, and alcohol . Therefore, it is necessary to apply the technology to prevent the above-mentioned components from being included in the finished product when the product is manufactured in which the Muslims export to many Arab countries.

As described above, since the use of alcohol in the production of red ginseng tablets contained 0.72 to 1.57% of alcohol in the final product, it was difficult to export to Arab countries. In order to solve these difficulties, it has been proposed not to use additives. However, it is difficult to manufacture red ginseng tablets by excluding the use of additives and the use of alcohol due to the characteristics of red ginseng tablets manufactured using pure red ginseng powder raw materials It is true.

Patent No. 10-0043915 Patent Application No. 10-1999-0034103 Patent No. 10-0384902 Patent Application No. 10-2002-0020388 Patent Application No. 10-2011-0126487

It is an object of the present invention to provide a red ginseng tablet without alcohol and a process for producing the same.

In order to attain the above object, the present invention provides a method for preparing an alcohol-free red ginseng tablet comprising the steps of:

1) mixing red ginseng powder and red ginseng powder with water to form a dough;

2) wet milling the dough to form uniformly atomized particles;

3) extruding and granulating the atomized particles to form granules; And

4) A step of tableting and drying the granules obtained by extrusion and assembly.

In addition, the present invention provides a red ginseng tablets containing no alcohol produced by the above method.

Hereinafter, the present invention will be described in detail.

First, terms used in the specification of the present invention will be described.

The term " rapid drying "referred to in the present invention means that the drying rate is constant and the free water near the surface of the sample is evaporated.

The term " reduced rate drying "referred to in the present invention means that the drying rate gradually decreases, meaning that moisture is diffused and evaporated at the center of the sample.

The term "red ginseng powder " referred to in the present invention means a powder product obtained by pulverizing red ginseng to have a particle size of 120mesh and containing the red ginseng powder in an amount of 85% or more.

"Red ginseng derivative" referred to in the present invention refers to a powder product having a particle size of 120 μm or less by pulverizing and separating red ginseng.

In the present invention, the weight ratio of the red ginseng powder to the red ginseng derivative in the step 1) may be in the range of 5: 1 to 12: 1, preferably 6: 1 to 10: 1, : 1 to 9: 1, but is not limited thereto.

By setting the ratio of the red ginseng powder to 5 times or more and 12 times or less, preferably 6 times or more and 10 times or less, more preferably 7 times or more and 9 times or less the red ginseng powder in the weight ratio range, It is possible to obtain a tablet formulation to be implemented in the present invention, that is, a red ginseng tablet having a uniform surface and a strength of 10 or more. When the red ginseng powder is mixed at a ratio of 5 times or less than that of the red ginseng powder in the weight ratio range or when it is mixed at a ratio of 12 times or more, uneven granules are generated due to a difference in water content during the manufacture of granules according to the variation of the particle size of the raw material, And poor tabletting due to a decrease in compressive force may result in a case where the tablet formulation to be implemented in the present invention may not be formed.

The amount of water to be added in the step 1) may be 5 to 20 parts by weight, preferably 7 to 15 parts by weight, more preferably 9 to 13 parts by weight, per 100 parts by weight of the mixture of the red ginseng powder and the red ginseng derivative. But not limited to,

When the amount of water is 5 parts by weight or less based on 100 parts by weight of the mixture of red ginseng powder and red ginseng powder, mixing of the powder and water is not properly performed and the water content of the dough becomes insufficient. Even when wet pulverized, And granule formation is incomplete, so that the tablet form can not be formed by compression. Also, when the amount of water is 20 parts by weight or more, the resulting dough becomes thin due to a high water content, and the color may change due to a high water content. Particles may not be formed even when wet- The flowability in the production of tablets by the above method is not preferable.

On the other hand, it has been reported that red ginseng is produced in the form of a ring. For example, Korean Patent Publication No. 10-0605659 discloses a method for producing a ring using a method comprising kneading the red ginseng to obtain a kneading state having a binding force by using the liquid extracted at the time of ginseng, Korean Patent No. 10-1171038 discloses that red ginseng powder is kneaded together with honey to be swollen in a ring form. However, since the conventional ring manufacturing method is a method of producing a spherical shaped pellet, the ring forming method is not applicable to the production of tablet in the form of a tablet, since the preparation itself is different from the manufacturing process of the tablet. In addition, the manufacturing facility and manufacturing method used in the manufacture of existing pans is a simple process in which raw material powder is kneaded with water, mechanically separated by a certain weight, rolled and dried, and there is a slight difference in the degree of kneading or puddling to be.

On the other hand, the method of producing tablet-free tablet of the present invention is designed to improve the problem of remaining the alcohol in the final product when the granule is manufactured by using a general tablet manufacturing method and tabletting method, In addition, the drying time / temperature increase is a technique to completely eliminate the alcohol component, and to overcome the limitations of this technology, the use of 100% water is used to eliminate the use of alcohol in the manufacturing process. In addition, by introducing the wet grinding (water granule production) method and the rate drying concept, it is possible to satisfy the most important condition (hardness 8 or more, size and weight uniformity) in the quality standard of the tablet formulation without containing alcohol, Technology, and has a superior effect in the production of tablets of tablet formulations.

In the step 2), the wet grinding may be performed by a high speed mixer, a pin mill grinding, a roll mill grinding, or the like. Preferably, sharp blades are mounted to make the granules uniform to a uniform degree. It is preferable to use a wet pulverizer. Examples of the wet pulverizer include a multipurpose mixer having a crushing capacity of 10 kg or more, a high-speed mixer, a crushing mixer, and the like. The pulverization may be performed at 2000 to 4000 RPM for 1 minute to 30 minutes, preferably at 2500 to 3500 RPM for 1 minute to 20 minutes, more preferably at 2700 to 3300 RPM for 1 minute to 10 minutes , But is not limited to. In order to form granules for tableting, the water content may be 3 to 17 parts by weight, preferably 5 to 15 parts by weight, more preferably 7 to 12 parts by weight based on 100 parts by weight of the kneaded mixture of step 1) However, this is not the case.

After the above wet grinding, the extrusion assembly is performed. It is preferable that each step is not delayed, but is performed within a short time, more preferably immediately. The reason for this is that when the tabblet manufacturing method of the present invention has high hygroscopicity due to the non-use of the alcohol, when the time is elapsed in connection with the sizing process by the oscillator after the wet grinding, the particles may accumulate and re-agglomerate.

In the step 3), the extrusion granulation may be carried out at a size of 10 to 30 meshes, preferably at a size of 15 to 25 meshes, and more preferably at a size of 18 to 23 meshes. Granulation with a particle size suitable for tableting can not be obtained when extrusion granulation is carried out at a size of 10 mesh or less, and when the size is 30mesh or more, a uniform tablet on the surface may not be obtained, which is not preferable .

In the step 4), the pressing pressure difference between the main pressure and the preload of the tableting machine may be 0.5 to 5 kg / cm 2, preferably 0.8 to 4 kg / cm 2, and more preferably 1 to 3 kg / But not limited to this.

Since alcohol was used at the time of preparing the conventional red ginseng tablet, wet granulation was easy to produce, and it was also excellent in compressibility at the time of rubbing. In the manufacturing method of the present invention, since the alcohol is not used, the compressive strength is increased compared to the existing one in order to compensate for the decrease in compressibility. Therefore, when the pressure difference between the main pressure and the preload is out of the range of 0.5 to 5 kg / cm < 2 >, there is a possibility that the tabbers having poor compressibility and having low hardness even when compressed are produced.

In the step 4), the drying is carried out for 15 to 35 hours at room temperature to evaporate the water in the tribett. The drying is carried out preferably for 20 to 30 hours, more preferably for 22 to 28 hours But not limited to, In the step 4), the natural evaporation condition is most suitable for increasing the hardness at room temperature, and the high temperature drying condition may be concurrently performed as needed when the hardness is insufficient. The high-temperature drying can be carried out in a reflux dryer at 60 to 100 ° C for 40 to 80 minutes, preferably at 70 to 90 ° C for 50 to 70 minutes, more preferably at 80 ° C for 60 minutes But not limited to,

In the preparation of red ginseng tablets using conventional alcohol, the tabblets were dried at a constant rate of 55 ° C. in a reflux dryer. However, in the manufacturing method of the present invention, the evaporation was carried out at room temperature to reduce the moisture content of the tabblets. As a result, a red ginseng tablet having a uniform surface, an excellent hardness of 10 or more and being resistant to moisture absorption is produced.

The red ginseng tbret according to the present invention can reduce the manufacturing cost due to the use of alcohol and can ensure the quality safety against the local legal regulation (alcohol standard) in the Arab region, thereby securing global quality competitiveness.

Fig. 1 is a view showing a process for manufacturing red ginseng tablets of Comparative Example 1 and Example 1. Fig.
Fig. 2 is a graph showing granules formed in Comparative Example 1 and Example 1 of the red ginseng tablet manufacturing process. Fig.
Fig. 3 is a diagram showing the appearance characteristics of the red ginseng tablets of Comparative Example 1 and Example 1. Fig.

Hereinafter, the present invention will be described in detail with reference to examples and comparative examples.

However, the following examples and comparative examples are for illustrative purposes only and are not intended to limit the scope of the present invention.

< Comparative Example  1> Conventional red ginseng using alcohol Tabret  Produce

The mixture was mixed so that the total amount of the red ginseng powder and the red ginseng powder was 8: 1 and the total amount was 9 kg. Then, 800 to 1,400 mL of 65 to 70% alcohol was added, and then the mixture was extruded using an oscillator extrusion granulator (model: P1MX02, manufactured by NAMJOO MACHINERY) The granules were extruded and assembled to a size of 32 meshes to prepare granules suitable for tableting. When the alcohol was added in this way, granules were prepared in the form of A in FIG. The prepared granules were tableted (preload: 7.0 kg / cm 2, main pressure: 5.8 kg / cm 2, difference between the main pressure and the preload: 1.2 kg / cm 2) using a tablet machine (model: MRC-36N, manufacturer: SEJONG). The red ginseng tablets were dried in a reflux dryer (53 ± 2 ° C., 50 minutes).

As shown in Fig. 3 (A), the prepared tabblets were found to have a uniform surface, but the alcohol remained in excess of 0.72 to 1.57%.

< Comparative Example  2> Alcohol Abated  Red ginseng Tabret  Produce

Red ginseng tablets with reduced alcohol content (less than 1%) were prepared. Red ginseng powder and red ginseng powder were mixed at a ratio of 8: 1 such that the total amount was 9 kg. 800 - 1400 ml of 65-70% alcohol was added to the mixed powder, and the mixture was homogeneously mixed. When the alcohol was added, it was confirmed that granules were produced in the form of A in FIG. The granules containing the above prepared sperm were extruded and assembled by 32 mesh extruder using an oscillator extrusion granulator to prepare granules having suitable particle size for tableting.

The granules containing the alcohol were tableted under high pressure using a tablet machine. The weight of the granules was increased from 3.26 ± 0.04 g to 3.32 ± 0.04 g under the maturing condition by 2% over the current weight. This takes into consideration the hygroscopicity due to overdrying. The tableted tablets of red ginseng were dried at 90 DEG C for 6 hours.

As a result, although the alcohol was reduced to 0.03%, there was still a problem that the alcohol remained, and the drying time was inevitable for the alcohol removal, so that the operation time was delayed due to the addition of the drying time, And quality fluctuation occurred.

< Comparative Example  3> Red ginseng without alcohol Tabret  Produce

Red ginseng powder and red ginseng powder were mixed at a ratio of 8: 1 such that the total amount was 4.5 kg. Purified water (10% of the mixed powder) was uniformly sprayed on the mixed powder and the water content was maintained at 10%. When the water was mixed, the raw material was subdivided to make the water content uniform. As a result, a massive raw material powder was produced (see Fig. 2B).

< Example  1> Red ginseng without alcohol Tabret  Produce

<1-1> Raw material Powder  Produce

Red ginseng powder and red ginseng powder were mixed at a ratio of 8: 1 such that the total amount was 4.5 kg. Purified water (10% of the mixed powder) was uniformly sprayed on the mixed powder and the water content was maintained at 10%. When the water was mixed, the raw material was subdivided to make the water content uniform.

<1-2> Wet milling and extrusion assembly

The massive powder of Example 1-1 was pulverized at 3000 RPM for 5 minutes using a wet pulverizer (pulverizer, filter pore). The water content was maintained at 7 to 12% to form granules for tabletting. After granulating the particles homogeneously, the granules were extruded and granulated to a size of 20 meshes using an oscillator extrusion granulator to prepare granules having suitable particle sizes for tableting. In the case of wet pulverization, uniform particles were produced without lumping in the form of C in Fig.

<1-3> High pressure Tableting

The granules were extruded and granulated using a tableting machine under high pressure conditions. Specifically, in order to enhance the compressive strength and to increase the hardness in order to compensate the degradation of the compressibility of the wet granules due to the use of the alcohol, the pressure difference of the basic / preload of the tablet press was increased as compared with that of the tablet of Comparative Example 1 : 7.0 kg / cm 2, main pressure: 5.6 kg / cm 2, difference between main pressure and preload: 1.4 kg / cm 2). The prepared tablets were dried under reduced rate drying conditions. The rate of drying was naturally evaporated at room temperature for 24 hours to allow water to move inside the tablet.

As a result, it was confirmed that the prepared tablet had a uniform surface and a high strength of 10 or more as shown in Fig. 3B (see Fig. 3B).

Claims (17)

1) mixing red ginseng powder and red ginseng powder with water to form a dough;
2) wet milling the dough to form uniformly atomized particles;
3) extruding and granulating the atomized particles to form granules; And
4) a step of tableting and drying the extruded granulated granules, wherein the alcohol-
The weight ratio of the red ginseng powder to the red ginseng powder in the step 1) ranges from 5: 1 to 12: 1,
The amount of water to be added in the step 1) is 5 to 20 parts by weight based on 100 parts by weight of the mixture of red ginseng powder and red ginseng powder,
Wherein the pressure difference of the main pressure / preload of the tableting machine is 0.5 to 5 kg / cm &lt; 2 &gt; during the step 4). delete The method according to claim 1,
Wherein the weight ratio of the red ginseng powder to the red ginseng powder in the step 1) ranges from 6: 1 to 10: 1. The method of claim 3,
Wherein the weight ratio of the red ginseng powder to the red ginseng powder in the step 1) is 7: 1 to 9: 1. delete The method according to claim 1,
Wherein the amount of water to be added in the step 1) is 7 to 15 parts by weight based on 100 parts by weight of the mixture of the red ginseng powder and the red ginseng derivative. The method of claim 6,
Wherein the amount of water added in step 1) is 9 to 13 parts by weight based on 100 parts by weight of the red ginseng powder and the red ginseng powder. The method according to claim 1,
And the extrusion assembly is performed in a size of 10 to 30 mesh in the step 3). The method of claim 8,
And the extrusion assembly is performed in a size of 15 to 25mesh in the step 3). The method of claim 9,
And the extrusion assembly is performed in a size of 18 to 23mesh in the step 3). delete The method according to claim 1,
Wherein the pressure difference of the main pressure / preload of the tableting machine is 0.8 to 4 kg / cm &lt; 2 &gt; during the step 4). The method of claim 12,
Wherein the pressure difference of the main pressure / preload of the tableting machine is 1 to 3 kg / cm &lt; 2 &gt; during the step 4). The method according to claim 1,
Wherein the drying in step 4) is carried out at room temperature for 15 to 35 hours. 15. The method of claim 14,
Wherein the drying in step 4) is carried out at room temperature for 20 to 30 hours. 16. The method of claim 15,
Wherein the drying in step 4) is carried out at room temperature for 22 to 28 hours. An alcohol-free red ginseng tablet produced by the method of any one of claims 1, 3, 4, 6, 10, and 12 to 16.

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