KR101450348B1 - 약물 부작용과 관련된 ｈｌａ 대립유전자 및 그 검출 방법 - Google Patents

약물 부작용과 관련된 ｈｌａ 대립유전자 및 그 검출 방법 Download PDF

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KR101450348B1
KR101450348B1 KR1020087027562A KR20087027562A KR101450348B1 KR 101450348 B1 KR101450348 B1 KR 101450348B1 KR 1020087027562 A KR1020087027562 A KR 1020087027562A KR 20087027562 A KR20087027562 A KR 20087027562A KR 101450348 B1 KR101450348 B1 KR 101450348B1
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hla
heteroaryl
nrs
alkyl
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KR20090031671A (ko
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유안-쫑 첸
슈엔-루 흥
치-룽 센
치-펭 창
신-유 린
웨이-수안 첸
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아카데미아 시니카
파미진 인크.
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes
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    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
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    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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KR1020087027562A 2006-05-11 2007-05-11 약물 부작용과 관련된 ｈｌａ 대립유전자 및 그 검출 방법 Expired - Fee Related KR101450348B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80012106P 2006-05-11 2006-05-11
US60/800,121 2006-05-11
PCT/US2007/068782 WO2007134235A2 (en) 2006-05-11 2007-05-11 Hla alleles associated with adverse drug reactions and methods for detecting such

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KR20090031671A KR20090031671A (ko) 2009-03-27
KR101450348B1 true KR101450348B1 (ko) 2014-10-14

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US (2) US7943309B2 (enExample)
EP (1) EP2016198B1 (enExample)
JP (1) JP2009536828A (enExample)
KR (1) KR101450348B1 (enExample)
CN (1) CN101454462A (enExample)
AU (1) AU2007249225B2 (enExample)
BR (1) BRPI0710436A8 (enExample)
CA (1) CA2651954C (enExample)
DK (1) DK2016198T3 (enExample)
ES (1) ES2422735T3 (enExample)
IL (1) IL194900A (enExample)
MY (1) MY150648A (enExample)
NZ (2) NZ597628A (enExample)
PL (1) PL2016198T3 (enExample)
PT (1) PT2016198E (enExample)
TW (1) TWI335937B (enExample)
WO (1) WO2007134235A2 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1536021A1 (en) * 2003-11-27 2005-06-01 Consortium National de Recherche en Genomique (CNRG) Method for HLA typing
US8927462B2 (en) 2010-04-12 2015-01-06 Academia Sinica Method for identifying HLA complexes associated with adverse drug reactions
JP5959634B2 (ja) * 2011-06-23 2016-08-02 チャン グン メディカル ファンデーション チャン グン メモリアル ホスピタル アット キールン フェニトインによって誘発される薬の副作用のリスク評価
CN102296109A (zh) * 2011-06-30 2011-12-28 北京思尔成生物技术有限公司 HLA-B*1502基因的SYBR Green I检测方法及其专用引物与试剂盒
US20150225788A1 (en) 2011-12-12 2015-08-13 Wen-Hung Chung Risk assessment for phenytoin-induced adverse drug reactions
CN102660635B (zh) * 2012-01-14 2014-03-12 长沙三济生物科技有限公司 一种定性检测hla-b*1502基因亚型的荧光pcr试剂盒
CN103114138B (zh) * 2013-01-27 2014-12-03 复旦大学 Pcr-ssp法定性检测hla-b*1502基因的方法及临床试剂盒
WO2015041603A1 (en) * 2013-09-17 2015-03-26 Agency For Science, Technology And Research Method for detection of a genetic variant
CN104017898B (zh) * 2014-06-25 2016-04-27 上海荻硕贝肯生物科技有限公司 快速检测hla-b*5801等位基因的引物、试剂盒及方法
CN104232781B (zh) * 2014-09-26 2017-04-19 陕西佰美基因股份有限公司 一种检测HLA‑B*5801等位基因的TaqMan探针实时荧光PCR方法
CN106119362B (zh) * 2016-06-30 2019-09-10 江苏伟禾生物科技有限公司 一种用于检测hla-b*1502等位基因的引物组及试剂盒
CN108929902B (zh) * 2018-07-28 2022-03-25 北京博奥晶典生物技术有限公司 用于检测等位基因hla-b*5801的肽核酸引物组合物、试剂盒及方法
CN109355358A (zh) * 2018-10-22 2019-02-19 江苏美因康生物科技有限公司 一种快速高效检测药源性皮肤不良反应相关基因多态性的试剂盒及方法
CN109554460B (zh) * 2018-12-17 2022-03-22 上海市疾病预防控制中心 一种基于hla基因多态性位点预测h7n9易感人群的检测方法及其用途
SG11202111473UA (en) * 2019-05-06 2021-11-29 Chang Gung Memorial Hospital Linkou Methods for assessing the risk of developing severe cutaneous adverse drug reactions induced by disease-modifying antirheumatic drugs, detection kit thereof and uses thereof
TWI804620B (zh) * 2019-05-06 2023-06-11 長庚醫療財團法人林口長庚紀念醫院 評估疾病調節抗風濕藥物引發嚴重皮膚藥物不良反應風險的方法、其檢測套組及其用途
CN111620924B (zh) * 2020-06-04 2026-07-31 华中农业大学 基于天然产物的药物设计方法、五环三萜类化合物、其制备方法及应用
CN113308532A (zh) * 2021-05-28 2021-08-27 上海康黎诊断技术有限公司 一种用于检测人hla-b*1502基因突变的特异性引物探针组合及其试剂盒，以及方法
WO2023080478A1 (ko) * 2021-11-02 2023-05-11 주식회사 랩 지노믹스 Ｈｌａ－ｂ＊5801 대립유전자 검출용 핵산 분자 및 이를 이용한 방법

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WO1994021818A1 (en) * 1993-03-18 1994-09-29 N.V. Innogenetics S.A. Process for typing hla-b using specific primers and probes sets
US5550039A (en) * 1995-03-07 1996-08-27 Hoffmann-La Roche Inc. Oligonucleotide primers for HLA class I B locus DNA typing
US6583139B1 (en) * 1997-07-31 2003-06-24 Eugene D. Thorsett Compounds which inhibit leukocyte adhesion mediated by VLA-4
BRPI0407569A (pt) * 2003-02-17 2006-02-14 Novartis Ag uso de s-10-hidróxi-10, 11-diidro-carbamazepina para o tratamento de ansiendade e distúrbios bipolares

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CN101454462A (zh) 2009-06-10
EP2016198B1 (en) 2013-05-01
AU2007249225B2 (en) 2013-06-27
IL194900A0 (en) 2009-08-03
TWI335937B (en) 2011-01-11
EP2016198A4 (en) 2010-07-21
WO2007134235A3 (en) 2008-01-17
US20080145846A1 (en) 2008-06-19
CA2651954A1 (en) 2007-11-22
JP2009536828A (ja) 2009-10-22
US8142999B2 (en) 2012-03-27
NZ572259A (en) 2012-03-30
TW200844238A (en) 2008-11-16
EP2016198A2 (en) 2009-01-21
ES2422735T3 (es) 2013-09-13
BRPI0710436A8 (pt) 2018-06-26
NZ597628A (en) 2013-07-26
WO2007134235A2 (en) 2007-11-22
MY150648A (en) 2014-02-14
AU2007249225A1 (en) 2007-11-22
PT2016198E (pt) 2013-07-29
US7943309B2 (en) 2011-05-17
US20110212439A1 (en) 2011-09-01
CA2651954C (en) 2014-02-25
DK2016198T3 (en) 2013-07-15
BRPI0710436A2 (pt) 2012-10-09
KR20090031671A (ko) 2009-03-27
PL2016198T3 (pl) 2013-12-31
IL194900A (en) 2013-02-28

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