KR101340021B1 - Manufacturing method of composition for improving of gum disease and composition for improving of gum disease manufactured by the same - Google Patents
Manufacturing method of composition for improving of gum disease and composition for improving of gum disease manufactured by the same Download PDFInfo
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- KR101340021B1 KR101340021B1 KR1020130083987A KR20130083987A KR101340021B1 KR 101340021 B1 KR101340021 B1 KR 101340021B1 KR 1020130083987 A KR1020130083987 A KR 1020130083987A KR 20130083987 A KR20130083987 A KR 20130083987A KR 101340021 B1 KR101340021 B1 KR 101340021B1
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- 208000024693 gingival disease Diseases 0.000 title claims abstract description 41
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- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- -1 chlorohydroxy aluminum Chemical compound 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
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- 238000009472 formulation Methods 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 210000004195 gingiva Anatomy 0.000 description 1
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- JZWFDVDETGFGFC-UHFFFAOYSA-N salacetamide Chemical group CC(=O)NC(=O)C1=CC=CC=C1O JZWFDVDETGFGFC-UHFFFAOYSA-N 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/76—Salicaceae (Willow family), e.g. poplar
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/312—Foods, ingredients or supplements having a functional effect on health having an effect on dental health
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Botany (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
본 발명은 잇몸질환 개선용 조성물의 제조방법 및 이에 의해 제조된 잇몸질환 개선용 조성물에 관한 것으로, 보다 상세하게는 잇몸을 단단하게 하며 잇몸질환을 신속하게 개선할 수 있는 잇몸질환 개선용 조성물의 제조방법 및 이에 의해 제조된 잇몸질환 개선용 조성물에 관한 것이다.
The present invention relates to a method for producing a composition for improving gum disease, and a composition for improving gum disease produced by the same, and more particularly to the preparation of a composition for improving gum disease that can stiffen the gum and quickly improve gum disease. It relates to a method and a composition for improving gum disease produced thereby.
일반적으로 잇몸질환을 예방하기 위하여 고안된 구강용 조성물에는 염화나트륨, 알란토인클로로히드록시 알루미늄, 아미노카프론산, 초산토코페롤 등 합성 원료들이 그 주를 이루고 있었다.
Generally, oral compositions designed to prevent gum disease were mainly composed of synthetic raw materials such as sodium chloride, allantoin chlorohydroxy aluminum, aminocaproic acid and tocopherol acetate.
그러나, 최근에는 천연 추출물에 대한 관심이 높아지면서 각종 식물에 대한 연구가 활발히 진행되고 있으며, 구강에의 효과들이 알려지면서 많은 식물 추출물들이 잇몸질환 예방 및 구취억제와 관련된 구강용 조성물에 응용되고 있다.
However, recently, as interest in natural extracts has increased, research on various plants is being actively conducted, and as the effects on the oral cavity are known, many plant extracts have been applied to oral compositions related to gum disease prevention and bad breath suppression.
대한민국공개특허 제10-2003-0000275호(2003.01.06.)는 녹차추출물에 의한 치약 제조방법에 관한 것으로서, 상기 녹차추출물은 카테킨 성분의 높은 항균력으로 인한 항균작용 및 항충치의 기능이 뛰어나고, 또한 입안의 입냄새를 제거하는데 효과가 탁월하여 구취제로서의 역할이 뛰어나다는 사실이 개시되어 있다.
Republic of Korea Patent Publication No. 10-2003-0000275 (2003.01.06.) Relates to a toothpaste manufacturing method by the green tea extract, the green tea extract is excellent in the antibacterial action and anti-cavities due to the high antibacterial activity of the catechin component, It is disclosed that the effect of removing bad breath in the mouth is excellent and serves as a bad breathing agent.
대한민국공개특허 제10-2002-0087672호(2002.11.23.)는 정향 추출물을 함유하고 있어 입안 가글시 청량감을 제공할 뿐만 아니라 항균 활성으로 인한 구취제거 및 잇몸질환을 예방하는데 뛰어난 효과가 있고 기존의 청정제가 지니지 못한 진통효과를 가지고 있다는 사실이 개시되어 있다.
Republic of Korea Patent Publication No. 10-2002-0087672 (2002.11.23.) Contains a clove extract not only provides a refreshing feeling in mouth mouth, but also has an excellent effect in preventing bad breath and gum disease due to antimicrobial activity and existing It is disclosed that cleaning agents have an analgesic effect that they do not have.
대한민국공개특허 제10-2002-0066042호(2002.08.14.)는 석류추출물을 함유한 구강 위생 증진용 조성물에 관한 것으로서, 석류 추출물이 활성산소와 산화질소 생성을 억제시키는 작용이 우수함을 확인하여 이러한 항산화 효능을 통하여 구강위생을 증진시키는데 역할이 뛰어나다는 사실이 개시되어 있다.
Republic of Korea Patent Publication No. 10-2002-0066042 (2002.08.14.) Relates to a composition for promoting oral hygiene containing a pomegranate extract, it is confirmed that the pomegranate extract is excellent in inhibiting the production of free radicals and nitric oxide It is disclosed that an excellent role in promoting oral hygiene through the antioxidant effect.
대한민국등록특허 제10-0307947호(2001.09.13.)는 식물추출물 파우더의 제조 방법 및 이 방법에 의해 제조된 식물추출물 파우더를 함유하는 구강용 조성물에 관한 것으로서, 인공적인 항생제, 살균제보다 민간에서 널리 알려져 온 약용 식물 추출물, 특히 솔잎을 사용하여 구강 내에서 우수한 치주질환 및 충치예방효과를 제공할 수 있다고 개시되어 있다.
Republic of Korea Patent No. 10-0307947 (September 13, 2001) relates to a method for producing a plant extract powder and a composition for oral cavity containing the plant extract powder prepared by the method, it is more widely used in civilian than artificial antibiotics, fungicides It is disclosed that known medicinal plant extracts, especially pine needles, can provide excellent periodontal disease and caries prevention effects in the oral cavity.
상기에서 살펴본 바와 같이, 많은 식물 추출물들이 구강 위생의 증진목적으로 배합되어 사용되어 오고 있으나, 대부분 빈약한 항균 효과를 나타내어 구강용 조성물로 사용하는데 어려움이 있었다.
As described above, many plant extracts have been used in combination for the purpose of promoting oral hygiene, but most have a poor antimicrobial effect, making it difficult to use as an oral composition.
본 발명의 목적은 잇몸을 단단하게 하며 잇몸질환을 신속하게 개선할 수 있는 잇몸질환 개선용 조성물의 제조방법 및 이에 의해 제조된 잇몸질환 개선용 조성물을 제공하는 것이다.
An object of the present invention is to provide a method for producing a composition for improving gum disease and a composition for improving gum disease, thereby making the gum hard and rapidly improving gum disease.
상기 목적을 달성하기 위하여 본 발명은 다음과 같은 수단을 제공한다.In order to achieve the above object, the present invention provides the following means.
본 발명은 산복숭아나무 가지, 산버들 가지 및 묏대추나무 뿌리를 혼합하여 혼합물을 만드는 단계(단계 1); 및 상기 혼합물에 물을 가하고 열수추출하는 단계(단계 2); 를 포함하는 잇몸질환 개선용 조성물의 제조방법을 제공한다.The present invention comprises a step of mixing a peach tree branch, a mountain willow branch and the root of the jujube tree to make a mixture (step 1); And adding water to the mixture and extracting hot water (step 2); It provides a method for producing a composition for improving gum disease comprising a.
상기 단계 1은, 상기 산복숭아나무 가지, 산버들 가지, 묏대추나무 뿌리를 3~10㎝로 자른 다음, 1 : 1 : 1 중량비(wt/wt/wt)로 혼합한다.In the step 1, the peach tree branch, the mountain willow branch, the root of the jujube tree cut to 3 ~ 10cm, and then mixed in a 1: 1 ratio by weight (wt / wt / wt).
상기 단계 2는, 상기 혼합물에 10~15배(w/w)의 물(water)을 가하여 100℃에서 1시간 가열한 후, 70~80℃에서 16~24시간 동안 추출한다.In step 2, 10 to 15 times (w / w) of water (water) is added to the mixture, and heated at 100 ° C. for 1 hour, followed by extraction at 70 to 80 ° C. for 16 to 24 hours.
상기 단계 1 이후에 상기 혼합물 100중량부에 대하여 조릿대 줄기 5~6중량부 및 할미꽃 뿌리 3~4중량부를 첨가한다.After step 1, 5 to 6 parts by weight of the stem and 3 to 4 parts by weight of pasqueflower root are added to 100 parts by weight of the mixture.
또한 본 발명은 상기 제조방법으로 제조되는 잇몸질환 개선용 조성물을 제공한다.
In another aspect, the present invention provides a composition for improving gum disease prepared by the above method.
본 발명에 따른 잇몸질환 개선용 조성물은 잇몸을 단단하게 하며 잇몸질환을 신속하게 개선할 수 있는 효과가 있다.
The composition for improving gum disease according to the present invention has an effect of hardening gums and rapidly improving gum disease.
이하, 본 발명을 상세히 설명하면 다음과 같다.
Hereinafter, the present invention will be described in detail.
먼저 본 발명에 따른 잇몸질환 개선용 조성물의 제조방법을 설명한다.
First, a method for preparing a composition for improving gum disease according to the present invention will be described.
본 발명의 잇몸질환 개선용 조성물의 제조방법은,Method for producing a composition for improving gum disease of the present invention,
산복숭아나무 가지, 산버들 가지 및 묏대추나무 뿌리를 혼합하여 혼합물을 만드는 단계(단계 1); 및Mixing peach tree branches, mountain willow branches and rootwood roots to form a mixture (step 1); And
상기 혼합물에 물을 가하고 열수추출하는 단계(단계 2); Adding water to the mixture and extracting hot water (step 2);
를 포함한다.
.
산복숭아(Prunus persica var. davidiana)는 앵도과에 속하며, 전국 산야에 자생하는 낙엽교목인 야생복숭아로, 흔히 돌복숭아, 개복숭아 등으로 불리기도 한다. 산복숭아와 일반 복숭아는 원조는 같다고 할 수 있으나, 산복숭아는 자연 상태에서 자라는 야생임에 반하여, 일반 복숭아는 사람에 의하여 개량되고, 화학비료 등을 사용하여 재배되어 온 것이어서, 그 크기와 맛, 그리고 함유된 성분들에 있어서 현저한 차이가 있다.
Prunus persica var. Davidiana belongs to the family Ando and is a wild peach, a deciduous tree that grows in wild fields all over the country. It is also called peach or peach. Although wild peach and common peach are the same in origin, wild peach is a wild one that grows in nature, whereas ordinary peach has been improved by humans and cultivated using chemical fertilizers. And there are significant differences in the components contained.
상기 산복숭아는 본초강목이나 동의보감 등 주요 의학서적에서 찾아볼 수 있는 대표적인 약재로서 어혈과 혈액 순환이 되지 않아 막힌 것을 치료하고 나쁜 기운을 없앤다. 또한 기가 위로 치밀어 오르는 것과 기침을 멎게 하며 변비, 설사, 부종, 복수가 차는데 효과가 있고, 살결을 곱게 하고, 주끈깨, 기미, 생리불순, 생리통, 기침, 관절염, 무좀, 습진, 안면신경마비 등을 치료한다.
The peach is a representative medicine that can be found in the main medical books, such as herbaceous tree or Dongbobom, heals blood clots and blood circulation, and heals the bad energy. It is also effective to keep the stomach up and coughing, constipation, diarrhea, swelling, and revenge. To cure.
본 발명에서는 일반 복숭아나무 가지가 아니라 산복숭아나무 가지를 사용함에 특징이 있다.
In the present invention, it is characterized by using the peach tree branch, not the general peach tree branch.
버드나무(Salix koreensis Andersson)는 아스피린의 주요작용 성분과 비슷한 성분(Salicyl)을 가지고 있어서 열을 내리게 하고 염증과 통증을 완화하는 작용을 한다고 알려져 있다.
Willow Tree ( Salix koreensis Andersson ) is known to have a similar composition (Salicyl) to the main action of aspirin to reduce heat and relieve inflammation and pain.
버드나무는 여러 종류가 있는데, 본 발명에서는 산버들(Salix floderusii var. glabra) 가지를 사용함에 특징이 있다.
There will be many kinds of willow tree, the present invention is characterized by using the branches of the Salber (Salix floderusii var. Glabra).
묏대추나무(Ziziphus jujuba)는 높이 8m 정도 자라는 낙엽 소교목 또는 관목으로, 산대추나무로 불린다. 수피는 흑갈색이며 가지에 다갈색의 굵은 가시가 있다. 뿌리는 열을 내리고 발모를 촉진하는 데 쓰인다.
Ziziphus jujuba is a deciduous arborescent or shrub that grows about 8m high and is called mountain jujube. The bark is dark brown with dark brown thick thorns on the branches. Roots are used to reduce heat and promote hair growth.
본 발명에서는 일반 대추나무 뿌리가 아니라 묏대추나무 뿌리를 사용함에 특징이 있다.
In the present invention, it is characterized by using the jujube root rather than the normal jujube root.
상기 산복숭아나무 가지, 산버들 가지, 묏대추나무 뿌리를 3~10㎝로 자른 다음, 1 : 1 : 1 중량비(wt/wt/wt)로 혼합하는 것이 바람직하다.
It is preferable to cut the peach tree branch, mountain willow branch, root jujube tree root to 3 ~ 10cm, and then mix in a 1: 1 ratio by weight (wt / wt / wt).
상기 단계 1 이후에 상기 혼합물 100중량부에 대하여 조릿대 줄기 5~6중량부 및 할미꽃 뿌리 3~4중량부를 첨가하는 단계가 추가될 수 있다.
After the step 1, 5 to 6 parts by weight of the stem and 3 to 4 parts by weight of the pasqueflower root may be added to 100 parts by weight of the mixture.
상기 조릿대는 높이 1m 안팎으로 자라는 대나무이며 산대나무로 불린다. 전국적으로 분포하고 있으며 산지의 나무 밑에 난다. 해열, 이뇨, 갈증을 멈추게 하는 효능을 가지고 있으며 적용질환은 가슴이 답답하고 열이 나는 증세, 소변이 잘 나오지 않는 증세, 소변이 붉으며 상태가 시원스럽지 못한 증세, 구내염, 입안이 마르는 증세 등이다.
The stalk is a bamboo that grows in and out of 1m in height and is called a mountain grove. Distributed throughout the country and under the trees of the mountains. It has the effect of stopping fever, diuresis and thirst, and applied diseases include stuffy chest and fever, poor urine, redness of urine, coolness, stomatitis, and dry mouth. .
상기 할미꽃은 온몸에 부드러운 흰털을 쓰고 있는 여러해살이풀이다. 굵고 긴 뿌리를 가지고 있다. 제주도를 제외한 전국 각지에 널리 분포하며 산과 들판의 양지바른 풀밭에 난다. 뿌리에 항균성 물질인 아네모닌(Anemonin)을 함유하며 해열, 수렴, 소염, 살균 등의 효능을 가지고 있으며 뜨거운 피를 식혀주는 작용도 한다. 적용질환으로 학질, 신경통, 코피 흐를 때, 이질설사, 치질로 인한 출혈, 월경곤란, 임파선염 등이다.
The pasqueflower is a perennial plant with soft white hairs all over the body. It has thick, long roots. It is widely distributed all over the country except Jeju Island and flies on sunny meadows of mountains and fields. It contains anemonin, an antimicrobial substance in the root, and has the effect of antipyretic, astringent, anti-inflammatory, antiseptic and also cools hot blood. Applicable diseases include mucosa, neuralgia, nosebleeds, dysentery diarrhea, bleeding due to hemorrhoids, dysmenorrhea and lymphadenitis.
상기 단계 2는 상기 혼합물에 10~15배(w/w)의 물(water)을 가하여 100℃에서 1시간 가열한 후, 70~80℃에서 16~24시간 동안 추출하는 것이 바람직하다.
In step 2, 10-15 times (w / w) of water is added to the mixture and heated at 100 ° C. for 1 hour, and then extracted at 70 ° C. to 80 ° C. for 16 to 24 hours.
또한, 본 발명은 상기 제조방법으로 제조되는 잇몸질환 개선용 조성물을 제공한다.
In addition, the present invention provides a composition for improving gum disease produced by the manufacturing method.
상기 잇몸질환은 구강내 염증을 유발하는 경우라면 특별히 제한되지 않으며, 예를 들어, 치은염, 치주염, 풍치, 충치, 지치우위염(사랑니염), 치주농양, 치은증식증, 부정교합, 치근막염, 마모증 또는 교모증 등을 포함하며, 보다 구체적으로는 치은염 또는 치주염일 수 있다.
The gum disease is not particularly limited as long as it causes inflammation in the oral cavity, for example, gingivitis, periodontitis, windworm, tooth decay, periodontitis (gardenitis), periodontal abscess, gingival hyperplasia, malocclusion, fasciitis, abrasion Or gliopathy and the like, and more specifically, may be gingivitis or periodontitis.
본 발명에 따른 잇몸질환 개선용 조성물은 제형 및 사용 목적에 따라 통상적으로 사용하는 연마제, 습윤제, 기포제, 결합제, 감미제, pH 조절제, 방부제, 향료, 증백제, 색소, 용제 등을 함유할 수 있다. 또한, 상기 잇몸질환 개선용 조성물은 연고, 페이스트, 치약, 스프레이, 가글용 액상제, 츄잉검 또는 패취제 등의 형태로 제형화될 수 있다.
The composition for improving gum disease according to the present invention may contain abrasives, wetting agents, foaming agents, binders, sweeteners, pH adjusting agents, preservatives, flavoring agents, brightening agents, pigments, solvents, and the like, which are commonly used according to the formulation and the purpose of use. In addition, the composition for improving gum disease may be formulated in the form of an ointment, paste, toothpaste, spray, liquid for the gargle, chewing gum or patch.
이하, 실시 예를 통하여 본 발명의 구성 및 효과를 더욱 상세히 설명하고자 한다. 이들 실시 예는 오로지 본 발명을 예시하기 위한 것일 뿐 본 발명의 범위가 이들 실시 예에 의해 제한되는 것은 아니다.
Hereinafter, the constitution and effects of the present invention will be described in more detail through examples. These embodiments are only for illustrating the present invention, and the scope of the present invention is not limited by these embodiments.
산복숭아나무 가지, 산버들 가지, 묏대추나무 뿌리를 3~10㎝로 자른 다음, 1 : 1 : 1 중량비(wt/wt/wt)로 혼합하여 혼합물을 만들었다. 상기 혼합물에 10배(w/w)의 물(water)을 가하여 100℃에서 1시간 가열한 후, 75℃에서 20시간 동안 추출하여 잇몸질환 개선용 조성물을 제조하였다.The peach tree branch, the mountain willow branch, and the root of the jujube tree cut to 3 ~ 10cm, and then mixed in a 1: 1 ratio by weight (wt / wt / wt) to make a mixture. 10 times (w / w) of water was added to the mixture, heated at 100 ° C. for 1 hour, and extracted at 75 ° C. for 20 hours to prepare a composition for improving gum disease.
실시예 1에서, 상기 혼합물 100중량부에 대하여 조릿대 줄기 5중량부 및 할미꽃 뿌리 3중량부를 첨가한 것을 제외하고 나머지는 동일하게 하여 잇몸질환 개선용 조성물을 제조하였다.
In Example 1, except that 5 parts by weight of the stem and 3 parts by weight of the pasqueflower root was added to 100 parts by weight of the mixture, the remainder was the same to prepare a composition for improving gum disease.
[비교예 1]Comparative Example 1
실시예 1에서, 상기 산복숭아나무 가지 대신에 일반 복숭아나무 가지를 사용한 것과, 상기 산버들 가지 대신에 일반 버드나무 가지를 사용한 것과, 상기 묏대추나무 뿌리 대신에 일반 대추나무 뿌리를 사용한 것을 제외하고 나머지는 동일하게 하여 잇몸질환 개선용 조성물을 제조하였다.
In Example 1, except that the use of ordinary peach tree branch instead of the wild peach tree branch, the general willow branch instead of the mountain willow branch, and the other except using the normal jujube root instead of the root of the jujube tree In the same manner to prepare a composition for improving gum disease.
[실험예 1][Experimental Example 1]
잇몸질환 개선효과를 확인하기 위해서 치은 지수를 측정하였다. 먼저, 피검자 60명을 선별한 후 실험기간 동안 항생제의 복용과 실험에 영향을 미칠 수 있는 구강진료수취를 금하였다. 실시예 1, 실시예 2 및 비교예 1 각각에 피검자를 20명씩 나누고 일 3회, 회당 2분 동안 가글링하도록 하였다. 치은염 지수를 하기 평가 기준에 따라 측정하였으며, 평가 결과는 하기 표 1에 나타내었다.To determine the effect of improving gum disease, the gingiva index was measured. First, 60 subjects were screened, and during the experiment period, the administration of antibiotics and the receipt of oral medical treatments that may affect the experiment were prohibited. Each of Example 1, Example 2, and Comparative Example 1 were divided into 20 subjects and gargled three times a day for 2 minutes. The gingivitis index was measured according to the following evaluation criteria, and the evaluation results are shown in Table 1 below.
<Talbott, Mandel 및 Chilton이 변형한 Loe의 치은염 지수><Loe's Gingivitis Index Modified by Talbott, Mandel and Chilton>
0: 염증 없음0: no inflammation
1: 경미 치은염(색조의 약한 변화 및 약한 부종)- 치주낭심측정시 출혈없음1: Mild gingivitis (weak change of color and weak edema)-no bleeding during periodontal cyst measurement
2: 중등 치은염(발적, 부종) - 치주낭심측정시 출혈2: Middle gingivitis (redness, edema) - Hemorrhage in measuring periodontal pouch
3: 고도 치은염(궤양) - 저절로 출혈되는 경향
3: highly gingivitis (ulcer)-tendency to bleed on its own
상기 표 1의 결과를 보면, 실시예 1과 실시예 2의 잇몸질환 개선용 조성물은 비교예 1의 잇몸질환 개선용 조성물에 비해 치은염 완화효과가 우수한 것으로 확인되었다.
Looking at the results of Table 1, it was confirmed that the composition for improving gum disease in Example 1 and Example 2 has an excellent gingivitis relief effect compared to the composition for improving gum disease in Comparative Example 1.
본 발명에 따른 잇몸질환 개선용 조성물은 잇몸을 단단하게 하며 잇몸질환을 신속하게 개선할 수 있는 효과가 있다.The composition for improving gum disease according to the present invention has an effect of hardening gums and rapidly improving gum disease.
Claims (5)
상기 혼합물에 물을 가하고 열수추출하는 단계(단계 2);
를 포함하는 잇몸질환 개선용 건강기능식품 조성물의 제조방법.
Mixing peach tree branches, mountain willow branches and rootwood roots to form a mixture (step 1); And
Adding water to the mixture and extracting hot water (step 2);
Method of producing a health functional food composition for improving gum disease.
상기 산복숭아나무 가지, 산버들 가지, 묏대추나무 뿌리를 3~10㎝로 자른 다음, 1 : 1 : 1 중량비(wt/wt/wt)로 혼합하는 잇몸질환 개선용 건강기능식품 조성물의 제조방법.
2. The method according to claim 1,
The peach tree branches, mountain willow branches, 묏 jujube tree roots cut to 3 ~ 10cm, 1: 1: 1 weight ratio (wt / wt / wt) to improve the gum disease improvement method for producing a health functional food composition.
상기 혼합물에 10~15배(w/w)의 물(water)을 가하여 100℃에서 1시간 가열한 후, 70~80℃에서 16~24시간 동안 추출하는 잇몸질환 개선용 건강기능식품 조성물의 제조방법.
2. The method according to claim 1,
10-15 times (w / w) of water (water) is added to the mixture is heated for 1 hour at 100 ℃, extraction of health functional food composition for gum disease improvement for 16 to 24 hours at 70 ~ 80 ℃ Way.
상기 단계 1 이후에 상기 혼합물 100중량부에 대하여 조릿대 줄기 5~6중량부 및 할미꽃 뿌리 3~4중량부를 첨가하는 잇몸질환 개선용 건강기능식품 조성물의 제조방법.
The method of claim 1,
Method of producing a health functional food composition for improving gum disease by adding 5 to 6 parts by weight of the stem and 3 to 4 parts by weight of pasqueflower root with respect to 100 parts by weight of the mixture after step 1.
Claims 1 to 4 of the health functional food composition for improving gum disease prepared by the method of any one of claims.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020130083987A KR101340021B1 (en) | 2013-07-17 | 2013-07-17 | Manufacturing method of composition for improving of gum disease and composition for improving of gum disease manufactured by the same |
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| KR1020130083987A KR101340021B1 (en) | 2013-07-17 | 2013-07-17 | Manufacturing method of composition for improving of gum disease and composition for improving of gum disease manufactured by the same |
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| KR101340021B1 true KR101340021B1 (en) | 2013-12-10 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102571768B1 (en) | 2023-02-24 | 2023-08-29 | 일동바이오사이언스(주) | Composition and health functional food containing Ligilactobacillus salivarius IDCC 3551 having inhibiting gum disease and halitosis ability |
| KR102646766B1 (en) | 2023-06-14 | 2024-03-13 | 일동바이오사이언스(주) | Composition and health functional food containing Bifidobacterium breve IDCC 4401 having inhibiting gum disease and halitosis ability |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20070082164A (en) * | 2006-02-15 | 2007-08-21 | (주)지원메디코스 | Oral cavity composition for preventing periodontal disease and gingivitis |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20070082164A (en) * | 2006-02-15 | 2007-08-21 | (주)지원메디코스 | Oral cavity composition for preventing periodontal disease and gingivitis |
Non-Patent Citations (1)
| Title |
|---|
| 오필선, 경희대학교 대학원 박사학위논문, "버드나무추출물과 트라넥사민산 배합 세치제의 치은염예방에 관한 연구" (2006) * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102571768B1 (en) | 2023-02-24 | 2023-08-29 | 일동바이오사이언스(주) | Composition and health functional food containing Ligilactobacillus salivarius IDCC 3551 having inhibiting gum disease and halitosis ability |
| KR102646766B1 (en) | 2023-06-14 | 2024-03-13 | 일동바이오사이언스(주) | Composition and health functional food containing Bifidobacterium breve IDCC 4401 having inhibiting gum disease and halitosis ability |
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