KR101238701B1 - 암-관련 단백질을 표적으로 하는 알엔에이아이 프로브 - Google Patents

암-관련 단백질을 표적으로 하는 알엔에이아이 프로브 Download PDF

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KR101238701B1
KR101238701B1 KR1020117025408A KR20117025408A KR101238701B1 KR 101238701 B1 KR101238701 B1 KR 101238701B1 KR 1020117025408 A KR1020117025408 A KR 1020117025408A KR 20117025408 A KR20117025408 A KR 20117025408A KR 101238701 B1 KR101238701 B1 KR 101238701B1
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misc
feature
cells
denotes uridine
rnai
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KR20110122883A (ko
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브르크하르트 얀센
마틴 이. 글리브
막심 시냐프스키
엘리아나 베랄디
이오안니스 피. 트루가코스
에프스타치오스 에스. 고노스
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더 유니버시티 오브 브리티쉬 콜롬비아
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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KR1020117025408A 2002-08-21 2003-08-21 암-관련 단백질을 표적으로 하는 알엔에이아이 프로브 Expired - Fee Related KR101238701B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US40519302P 2002-08-21 2002-08-21
US60/405,193 2002-08-21
US40815202P 2002-09-03 2002-09-03
US60/408,152 2002-09-03
US47238703P 2003-05-20 2003-05-20
US60/472,387 2003-05-20
PCT/CA2003/001277 WO2004018676A2 (en) 2002-08-21 2003-08-21 Rnai probes targeting cancer-related proteins

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KR1020057002963A Division KR101212512B1 (ko) 2002-08-21 2003-08-21 암-관련 단백질을 표적으로 하는 알엔에이아이 프로브

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KR20110122883A KR20110122883A (ko) 2011-11-11
KR101238701B1 true KR101238701B1 (ko) 2013-03-05

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KR1020117025408A Expired - Fee Related KR101238701B1 (ko) 2002-08-21 2003-08-21 암-관련 단백질을 표적으로 하는 알엔에이아이 프로브
KR1020107028249A Expired - Fee Related KR101117673B1 (ko) 2002-08-21 2003-08-21 암-관련 단백질을 표적으로 하는 알엔에이아이 프로브
KR1020057002963A Expired - Fee Related KR101212512B1 (ko) 2002-08-21 2003-08-21 암-관련 단백질을 표적으로 하는 알엔에이아이 프로브

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KR1020107028249A Expired - Fee Related KR101117673B1 (ko) 2002-08-21 2003-08-21 암-관련 단백질을 표적으로 하는 알엔에이아이 프로브
KR1020057002963A Expired - Fee Related KR101212512B1 (ko) 2002-08-21 2003-08-21 암-관련 단백질을 표적으로 하는 알엔에이아이 프로브

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Country Link
US (5) US8252918B2 (https=)
EP (2) EP2263679B1 (https=)
JP (4) JP4717633B2 (https=)
KR (3) KR101238701B1 (https=)
AU (1) AU2003258426B2 (https=)
CA (2) CA2494766C (https=)
IL (3) IL166658A (https=)
NO (2) NO334573B1 (https=)
NZ (1) NZ552872A (https=)
WO (1) WO2004018676A2 (https=)

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WO2003062421A1 (en) * 2002-01-17 2003-07-31 The University Of British Columbia Bispecific antisense olignucleotides that inhibit igfbp-2 and igfbp-5 and methods of using same
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KR101238701B1 (ko) * 2002-08-21 2013-03-05 더 유니버시티 오브 브리티쉬 콜롬비아 암-관련 단백질을 표적으로 하는 알엔에이아이 프로브
US7635673B2 (en) 2003-03-25 2009-12-22 The Board Of Trustees Of The University Of Illinois Methods of inhibiting tumor cell proliferation
US20040220131A1 (en) * 2003-04-18 2004-11-04 The University Of British Columbia Method for treatment of cancerous angiogenic disorders
US20050019918A1 (en) * 2003-06-03 2005-01-27 Hidetoshi Sumimoto Treatment of cancer by inhibiting BRAF expression
JP2005013221A (ja) * 2003-06-03 2005-01-20 Keio Gijuku Ｂｒａｆ発現抑制を利用した癌の治療
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US8710020B2 (en) 2004-04-02 2014-04-29 The University Of British Columbia Clusterin antisense therapy for treatment of cancer
ATE501252T1 (de) * 2004-06-22 2011-03-15 Univ Illinois Verfahren zur inhibierung von tumorzellwachstum mit foxm1 sirns
WO2006012522A1 (en) * 2004-07-23 2006-02-02 Pacific Edge Biotechnology Ltd. Urine markers for detection of bladder cancer
WO2006035432A2 (en) * 2004-09-27 2006-04-06 Tel Hashomer Medical Research Infrastructure And Services Ltd. Gene silencing for use in dermatology
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ES2543341T3 (es) 2005-09-13 2015-08-18 National Research Council Of Canada Métodos y composiciones para modular la actividad de células tumorales
US8029980B2 (en) 2006-09-29 2011-10-04 The Board Of Trustees Of The University Of Illinois Identification and use of agents that modulate oncogenic transcription agent activity
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WO2008094516A2 (en) 2007-01-29 2008-08-07 City Of Hope Multi-targeting short interfering rnas
CA2679757A1 (en) * 2007-03-02 2008-09-12 Mdrna, Inc. Nucleic acid compounds for inhibiting erbb family gene expression and uses thereof
US8217161B2 (en) * 2008-04-22 2012-07-10 Clemson University Research Foundation Methods of inhibiting multiple cytochrome P450 genes with siRNA
EA034462B1 (ru) 2009-11-24 2020-02-11 Алетиа Байотерапьютикс Инк. Антикластериновые антитела и антигенсвязывающие фрагменты и их использование для уменьшения объема новообразований
EP2673363B1 (en) 2011-02-11 2017-08-23 The Rockefeller University Treatment of angiogenesis disorders
US9822170B2 (en) 2012-02-22 2017-11-21 Alethia Biotherapeutics Inc. Co-use of a clusterin inhibitor with an EGFR inhibitor to treat cancer
CA2844640A1 (en) 2013-12-06 2015-06-06 The University Of British Columbia Method for treatment of castration-resistant prostate cancer
CN106282185B (zh) * 2016-08-18 2020-06-26 广州市锐博生物科技有限公司 一种用于抑制簇集蛋白基因表达的成套siRNA及其应用
WO2024214933A1 (ko) * 2023-04-13 2024-10-17 한양대학교 에리카산학협력단 인산화된 igfbp5의 과도한 생성을 차단하여 암을 예방 또는 치료하는 방법
KR102923964B1 (ko) 2023-04-13 2026-02-09 한양대학교 에리카산학협력단 Igfbp5 돌연변이체 또는 이를 발현하는 벡터를 유효성분으로 포함하는 암 예방 또는 치료용 약학적 조성물
WO2025041340A1 (ja) * 2023-08-24 2025-02-27 株式会社Dti 二重特異性核酸

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AU2003258426B2 (en) 2008-04-10
AU2003258426A1 (en) 2004-03-11
EP1532249A2 (en) 2005-05-25
JP2013150624A (ja) 2013-08-08
KR20100135335A (ko) 2010-12-24
US7820635B2 (en) 2010-10-26
KR101117673B1 (ko) 2012-03-07
KR20110122883A (ko) 2011-11-11
IL166658A (en) 2014-11-30
NO334573B1 (no) 2014-04-14
JP2010193908A (ja) 2010-09-09
EP2263679B1 (en) 2014-10-08
NO20121038L (no) 2005-05-20
JP4717633B2 (ja) 2011-07-06
WO2004018676A3 (en) 2004-08-12
IL197159A0 (en) 2011-07-31
EP2263679A2 (en) 2010-12-22
IL233352A0 (en) 2014-08-31
NZ552872A (en) 2007-11-30
US20080274996A1 (en) 2008-11-06
CA2494766A1 (en) 2004-03-04
US9487777B2 (en) 2016-11-08
US20110009472A1 (en) 2011-01-13
US8252918B2 (en) 2012-08-28
US8759308B2 (en) 2014-06-24
US7964717B2 (en) 2011-06-21
CA2494766C (en) 2015-05-12
IL197159A (en) 2016-11-30
US20120202873A1 (en) 2012-08-09
CA2882443C (en) 2016-12-13
US20060178329A1 (en) 2006-08-10
JP5171887B2 (ja) 2013-03-27
JP5662766B2 (ja) 2015-02-04
WO2004018676A2 (en) 2004-03-04
EP2263679A3 (en) 2011-10-12
JP2011036267A (ja) 2011-02-24
NO20051423L (no) 2005-05-20
NO337130B1 (no) 2016-01-25
US20040096882A1 (en) 2004-05-20
KR101212512B1 (ko) 2012-12-26
JP2006500958A (ja) 2006-01-12
CA2882443A1 (en) 2004-03-04
KR20050042483A (ko) 2005-05-09
IL166658A0 (en) 2006-01-15

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