KR101166955B1 - 레발부테롤 염 - Google Patents

레발부테롤 염 Download PDF

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Publication number
KR101166955B1
KR101166955B1 KR1020087028024A KR20087028024A KR101166955B1 KR 101166955 B1 KR101166955 B1 KR 101166955B1 KR 1020087028024 A KR1020087028024 A KR 1020087028024A KR 20087028024 A KR20087028024 A KR 20087028024A KR 101166955 B1 KR101166955 B1 KR 101166955B1
Authority
KR
South Korea
Prior art keywords
crystals
tartrate
ethanol
levalbuterol
micronized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020087028024A
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English (en)
Korean (ko)
Other versions
KR20080103614A (ko
Inventor
폴 맥글린
로저 베케일
크레이그 스터지
Original Assignee
선오비온 파마슈티컬스 인코포레이티드
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32507867&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR101166955(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 선오비온 파마슈티컬스 인코포레이티드 filed Critical 선오비온 파마슈티컬스 인코포레이티드
Publication of KR20080103614A publication Critical patent/KR20080103614A/ko
Application granted granted Critical
Publication of KR101166955B1 publication Critical patent/KR101166955B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
    • C07C215/58—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C07C215/60—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain the chain having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/002—Details of inhalators; Constructional features thereof with air flow regulating means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K3/00—Materials not provided for elsewhere
    • C09K3/30—Materials not provided for elsewhere for aerosols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0468—Liquids non-physiological
    • A61M2202/0484—Alcohol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0468—Liquids non-physiological
    • A61M2202/0488—Surfactant, e.g. for the lung
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Otolaryngology (AREA)
  • Dispersion Chemistry (AREA)
  • Materials Engineering (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Cosmetics (AREA)
KR1020087028024A 2002-12-10 2003-12-08 레발부테롤 염 Expired - Fee Related KR101166955B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43219502P 2002-12-10 2002-12-10
US60/432,195 2002-12-10
PCT/US2003/037079 WO2004052835A1 (en) 2002-12-10 2003-12-08 Levalbuterol salt

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020057010435A Division KR20050088307A (ko) 2002-12-10 2003-12-08 레발부테롤 염

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020107014278A Division KR20100080865A (ko) 2002-12-10 2003-12-08 레발부테롤 염

Publications (2)

Publication Number Publication Date
KR20080103614A KR20080103614A (ko) 2008-11-27
KR101166955B1 true KR101166955B1 (ko) 2012-07-19

Family

ID=32507867

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020107014278A Ceased KR20100080865A (ko) 2002-12-10 2003-12-08 레발부테롤 염
KR1020087028024A Expired - Fee Related KR101166955B1 (ko) 2002-12-10 2003-12-08 레발부테롤 염
KR1020057010435A Ceased KR20050088307A (ko) 2002-12-10 2003-12-08 레발부테롤 염

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020107014278A Ceased KR20100080865A (ko) 2002-12-10 2003-12-08 레발부테롤 염

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020057010435A Ceased KR20050088307A (ko) 2002-12-10 2003-12-08 레발부테롤 염

Country Status (19)

Country Link
US (8) US7256310B2 (enExample)
EP (3) EP1671942B2 (enExample)
JP (1) JP4570960B2 (enExample)
KR (3) KR20100080865A (enExample)
AT (2) ATE324364T1 (enExample)
AU (1) AU2003295695B2 (enExample)
CA (1) CA2507572C (enExample)
CY (2) CY1106315T1 (enExample)
DE (2) DE60336089D1 (enExample)
DK (3) DK1572622T3 (enExample)
ES (3) ES2626648T3 (enExample)
IL (2) IL168739A (enExample)
MX (1) MXPA05006087A (enExample)
NO (1) NO331649B1 (enExample)
NZ (1) NZ541168A (enExample)
PL (1) PL212725B1 (enExample)
PT (3) PT1671942E (enExample)
SI (2) SI1572622T1 (enExample)
WO (1) WO2004052835A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6466862B1 (en) * 1999-04-19 2002-10-15 Bruce DeKock System for providing traffic information
EP1791534A1 (en) * 2004-09-09 2007-06-06 Cipla Ltd. Pharmaceutical composition comprising an isomer of a betamimetic agent and an anti-cholinergic agent
MX2007007378A (es) * 2004-12-17 2007-08-14 Cipla Ltd Compuestos y composiciones farmaceuticas.
US7579505B2 (en) 2004-12-17 2009-08-25 Cipla Limited Crystalline levosalbutamol sulphate and polymorphic forms thereof
US8542097B2 (en) 2011-04-13 2013-09-24 Jingle Technologies Llc Systems and methods for transmitting information, alerts, and/or comments to participants based on location information
EP3042892A1 (en) 2015-01-09 2016-07-13 Deva Holding Anonim Sirketi Amorphisation of levosalbutamol tartrate
CN106727318A (zh) * 2016-12-22 2017-05-31 山东京卫制药有限公司 一种气雾剂及其制备方法
WO2021188809A1 (en) * 2020-03-19 2021-09-23 Cai Gu Huang Inhalable formulation of a solution containing levalbuterol tartrate

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GB1200886A (en) 1966-09-23 1970-08-05 Allen & Hanburys Ltd Phenylaminoethanol derivatives
GB8828477D0 (en) † 1988-12-06 1989-01-05 Riker Laboratories Inc Medical aerosol formulations
US5776434A (en) 1988-12-06 1998-07-07 Riker Laboratories, Inc. Medicinal aerosol formulations
US5225183A (en) 1988-12-06 1993-07-06 Riker Laboratories, Inc. Medicinal aerosol formulations
US5345980A (en) 1989-09-21 1994-09-13 Glaxo Group Limited Method and apparatus an aerosol container
US5362755A (en) 1990-01-05 1994-11-08 Sepracor, Inc. Method for treating asthma using optically pure (R)-albuterol
US5255183A (en) * 1990-05-29 1993-10-19 Interactive Voice Data System Inc. Telephone-based personnel tracking system
DE69233659T2 (de) 1991-06-10 2007-09-13 Schering Corp. Fluorchlorkohlenwasserstofffreie Aerosolformulierungen
DE69232034T2 (de) 1991-12-18 2002-06-06 Minnesota Mining And Mfg. Co., Saint Paul Aerosolzusammensetzungen für Arzneimittelsuspensionen
US5399765A (en) 1994-05-23 1995-03-21 Sepracor, Inc. Enantioselective preparation of optically pure albuterol
US5545745A (en) * 1994-05-23 1996-08-13 Sepracor, Inc. Enantioselective preparation of optically pure albuterol
PT820279E (pt) * 1995-04-14 2002-11-29 Smithkline Beecham Corp Inalador de doses calibradas para albuterol
US5603918A (en) 1995-06-09 1997-02-18 Boehringer Ingelheim Pharmaceuticals, Inc. Aerosol composition of a salt of ipratropium and a salt of albuterol
US6040344A (en) 1996-11-11 2000-03-21 Sepracor Inc. Formoterol process
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GB0030171D0 (en) 2000-12-11 2001-01-24 Cipla Ltd Process for preparing isomers of salbutamol
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CN1206205C (zh) * 2001-04-26 2005-06-15 中国科学院成都有机化学研究所 R－沙丁胺醇酒石酸盐的制备方法
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Title
해당사항 없음

Also Published As

Publication number Publication date
DK1671942T4 (da) 2014-09-22
SI1671942T1 (sl) 2011-04-29
US20180222845A1 (en) 2018-08-09
EP2292584A1 (en) 2011-03-09
MXPA05006087A (es) 2005-09-30
DK1671942T3 (da) 2011-04-26
US20040115136A1 (en) 2004-06-17
NZ541168A (en) 2008-10-31
EP1671942B1 (en) 2011-02-16
KR20080103614A (ko) 2008-11-27
US7256310B2 (en) 2007-08-14
CA2507572A1 (en) 2004-06-24
AU2003295695A1 (en) 2004-06-30
DE60304900T2 (de) 2006-10-19
ES2263051T3 (es) 2006-12-01
JP2006509802A (ja) 2006-03-23
EP2292584B1 (en) 2017-03-01
PL377336A1 (pl) 2006-01-23
PT2292584T (pt) 2017-06-12
PT1572622E (pt) 2006-08-31
PT1671942E (pt) 2011-05-11
US20100272654A1 (en) 2010-10-28
SI1671942T2 (sl) 2014-10-30
IL212369A (en) 2013-08-29
NO20053339D0 (no) 2005-07-08
IL168739A (en) 2011-06-30
ES2626648T3 (es) 2017-07-25
ATE324364T1 (de) 2006-05-15
KR20100080865A (ko) 2010-07-12
US20160368858A1 (en) 2016-12-22
CY1106315T1 (el) 2011-10-12
ES2361172T5 (es) 2014-09-22
ATE498604T1 (de) 2011-03-15
US20130236515A1 (en) 2013-09-12
JP4570960B2 (ja) 2010-10-27
DE60304900D1 (de) 2006-06-01
AU2003295695B2 (en) 2009-08-20
EP1671942A1 (en) 2006-06-21
EP1572622B1 (en) 2006-04-26
US20080119564A1 (en) 2008-05-22
CY1111330T1 (el) 2015-08-05
NO331649B1 (no) 2012-02-13
DE60336089D1 (de) 2011-03-31
EP1671942B2 (en) 2014-07-23
CA2507572C (en) 2011-04-19
US8765153B2 (en) 2014-07-01
WO2004052835A1 (en) 2004-06-24
IL212369A0 (en) 2011-06-30
US20130028845A1 (en) 2013-01-31
PL212725B1 (pl) 2012-11-30
EP1572622A1 (en) 2005-09-14
KR20050088307A (ko) 2005-09-05
DK1572622T3 (da) 2006-08-28
NO20053339L (no) 2005-09-07
DK2292584T3 (en) 2017-05-01
ES2361172T3 (es) 2011-06-14
US20150071969A1 (en) 2015-03-12
SI1572622T1 (sl) 2006-10-31

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