KR101164262B1 - 테트라시클린의 옥사졸 유도체 - Google Patents

테트라시클린의 옥사졸 유도체 Download PDF

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Publication number
KR101164262B1
KR101164262B1 KR1020067013606A KR20067013606A KR101164262B1 KR 101164262 B1 KR101164262 B1 KR 101164262B1 KR 1020067013606 A KR1020067013606 A KR 1020067013606A KR 20067013606 A KR20067013606 A KR 20067013606A KR 101164262 B1 KR101164262 B1 KR 101164262B1
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KR
South Korea
Prior art keywords
dimethylamino
trihydroxy
dioxo
oxazole
bis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020067013606A
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English (en)
Korean (ko)
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KR20060105047A (ko
Inventor
파이크-엔지 섬
데이비드 브라이언 하우
다린 윌리암 홉퍼
매튜 더글라스 베라
조슈아 제임스 사바티니
Original Assignee
와이어쓰 엘엘씨
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Application filed by 와이어쓰 엘엘씨 filed Critical 와이어쓰 엘엘씨
Publication of KR20060105047A publication Critical patent/KR20060105047A/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/62—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems having two or more ring systems containing condensed 1,3-oxazole rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
KR1020067013606A 2003-12-08 2004-12-07 테트라시클린의 옥사졸 유도체 Expired - Fee Related KR101164262B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US52792803P 2003-12-08 2003-12-08
US60/527,928 2003-12-08
US58482304P 2004-07-01 2004-07-01
US60/584,823 2004-07-01
PCT/US2004/040850 WO2005056538A1 (en) 2003-12-08 2004-12-07 Oxazole derivatives of tetracyclines

Publications (2)

Publication Number Publication Date
KR20060105047A KR20060105047A (ko) 2006-10-09
KR101164262B1 true KR101164262B1 (ko) 2012-07-09

Family

ID=34681543

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020067013606A Expired - Fee Related KR101164262B1 (ko) 2003-12-08 2004-12-07 테트라시클린의 옥사졸 유도체

Country Status (25)

Country Link
US (3) US7176225B2 (enExample)
EP (2) EP2157085B1 (enExample)
JP (1) JP4848287B2 (enExample)
KR (1) KR101164262B1 (enExample)
CN (1) CN100545151C (enExample)
AR (1) AR047274A1 (enExample)
AT (2) ATE525365T1 (enExample)
AU (1) AU2004297243B2 (enExample)
BR (1) BRPI0417421A (enExample)
CA (1) CA2546895A1 (enExample)
CO (1) CO5700818A2 (enExample)
CR (1) CR8437A (enExample)
DE (1) DE602004023417D1 (enExample)
EC (1) ECSP066605A (enExample)
ES (2) ES2372635T3 (enExample)
IL (2) IL176162A (enExample)
MY (1) MY146098A (enExample)
NO (1) NO20062629L (enExample)
PA (1) PA8619601A1 (enExample)
PE (1) PE20050995A1 (enExample)
RU (1) RU2415844C2 (enExample)
SG (1) SG148216A1 (enExample)
TW (1) TW200528437A (enExample)
UA (2) UA83266C2 (enExample)
WO (1) WO2005056538A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1753713T3 (pl) * 2004-05-21 2017-02-28 President And Fellows Of Harvard College Synteza tetracyklin oraz ich analogów
CA2585418A1 (en) 2004-10-25 2006-05-04 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
JP2009502809A (ja) * 2005-07-21 2009-01-29 パラテック ファーマシューティカルズ インコーポレイテッド １０−置換テトラサイクリンおよびその使用方法
CA2648668C (en) 2006-04-07 2015-06-23 The President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
US8440646B1 (en) 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
EP2487160B1 (en) 2006-10-11 2016-02-03 President and Fellows of Harvard College Synthesis of Enone Intermediate
US8121767B2 (en) * 2007-11-02 2012-02-21 GM Global Technology Operations LLC Predicted and immediate output torque control architecture for a hybrid powertrain system
US8252946B2 (en) 2007-11-14 2012-08-28 Sandoz Ag Crystalline forms of tigecycline hydrochloride
CA2730377C (en) * 2008-07-11 2017-09-19 Neumedics Tetracycline derivatives with reduced antibiotic activity and neuroprotective benefits
EP2376433B1 (en) 2008-12-18 2014-10-29 Sandoz AG Crystalline form c of tigecycline dihydrochloride and methods for its preparation
US9073829B2 (en) 2009-04-30 2015-07-07 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494903A (en) 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
KR100309539B1 (ko) 1992-08-13 2002-08-31 아메리칸사이아나미드컴파니 신규한-7-(치환)-9-(치환글리실)아미도)-6-데메틸-6-데옥시테트라사이클린및그의중간체및그들의생산방법

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US26253A (en) * 1859-11-29 Vegetable-cutter
US2482055A (en) 1948-02-11 1949-09-13 American Cyanamid Co Aureomycin and preparation of same
US3007965A (en) 1959-02-13 1961-11-07 American Cyanamid Co New tetracyclines produced by streptomyces aureofaciens
US3043875A (en) 1959-10-22 1962-07-10 Pfizer & Co C Halogenated tetracycline derivatives and processes for their preparation
FR1430859A (enExample) 1960-05-23 1966-05-25
US3338963A (en) 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
US3148212A (en) 1961-12-22 1964-09-08 American Cyanamid Co Reductive alkylation process
US3360557A (en) 1963-05-10 1967-12-26 American Cyanamid Co 9-hydroxytetracyclines and a process of preparing same
USRE26253E (en) 1963-05-17 1967-08-15 And z-alkylamino-g-deoxytetracycline
US3341585A (en) 1966-05-06 1967-09-12 American Cyanamid Co Substituted 7-and/or 9-amino-6-deoxytetracyclines
US3360561A (en) 1967-06-19 1967-12-26 American Cyanamid Co Nitration of tetracyclines
US3518306A (en) 1968-02-19 1970-06-30 American Cyanamid Co 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines
US4806529A (en) 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
DE69232302T4 (de) * 1991-10-04 2003-02-13 American Cyanamid Co., Wayne 7-Substituierte-9-substituierte Amino-6-Demethyl-6-Deoxy-Tetracycline
CA2378990A1 (en) * 1999-08-10 2001-02-15 Siegfried B. Christensen, Iv 1,4-substituted 4,4-diaryl cyclohexanes
AU2002318238A1 (en) * 2001-07-13 2003-01-29 Paratek Pharmaceuticals, Inc. Tetracycline compounds having target therapeutic activities

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494903A (en) 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
KR100309539B1 (ko) 1992-08-13 2002-08-31 아메리칸사이아나미드컴파니 신규한-7-(치환)-9-(치환글리실)아미도)-6-데메틸-6-데옥시테트라사이클린및그의중간체및그들의생산방법

Also Published As

Publication number Publication date
TW200528437A (en) 2005-09-01
US20080177080A1 (en) 2008-07-24
AU2004297243A1 (en) 2005-06-23
US20080064667A1 (en) 2008-03-13
BRPI0417421A (pt) 2007-03-13
PA8619601A1 (es) 2006-03-24
SG148216A1 (en) 2008-12-31
EP1692117A1 (en) 2006-08-23
ATE525365T1 (de) 2011-10-15
WO2005056538A1 (en) 2005-06-23
CR8437A (es) 2006-10-06
AU2004297243B2 (en) 2011-02-17
EP2157085B1 (en) 2011-09-21
UA83268C2 (en) 2008-06-25
CA2546895A1 (en) 2005-06-23
US7365087B2 (en) 2008-04-29
AR047274A1 (es) 2006-01-11
KR20060105047A (ko) 2006-10-09
JP4848287B2 (ja) 2011-12-28
US20050153944A1 (en) 2005-07-14
PE20050995A1 (es) 2006-01-11
JP2007515411A (ja) 2007-06-14
US7176225B2 (en) 2007-02-13
RU2006118367A (ru) 2008-01-20
IL176162A (en) 2011-09-27
UA83266C2 (en) 2008-06-25
IL206050A (en) 2013-01-31
IL176162A0 (en) 2006-10-05
EP2157085A1 (en) 2010-02-24
NO20062629L (no) 2006-09-06
IL206050A0 (en) 2010-11-30
RU2415844C2 (ru) 2011-04-10
EP1692117B1 (en) 2009-09-30
ATE444290T1 (de) 2009-10-15
MY146098A (en) 2012-06-29
CO5700818A2 (es) 2006-11-30
ES2372635T3 (es) 2012-01-25
DE602004023417D1 (de) 2009-11-12
ECSP066605A (es) 2006-10-25
ES2331574T3 (es) 2010-01-08
CN1890226A (zh) 2007-01-03
CN100545151C (zh) 2009-09-30

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