KR101121871B1 - 어성초 유래 카페익산을 유효성분으로 포함하는 토포아이소머라아제 ⅰ 억제제, 혈액암 질환 예방 및 치료용 약학적 조성물, 및 건강식품 - Google Patents
어성초 유래 카페익산을 유효성분으로 포함하는 토포아이소머라아제 ⅰ 억제제, 혈액암 질환 예방 및 치료용 약학적 조성물, 및 건강식품 Download PDFInfo
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- KR101121871B1 KR101121871B1 KR1020090100396A KR20090100396A KR101121871B1 KR 101121871 B1 KR101121871 B1 KR 101121871B1 KR 1020090100396 A KR1020090100396 A KR 1020090100396A KR 20090100396 A KR20090100396 A KR 20090100396A KR 101121871 B1 KR101121871 B1 KR 101121871B1
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- caffeic acid
- topoisomerase
- extract
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- pharmaceutical composition
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- A—HUMAN NECESSITIES
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- A61K2236/30—Extraction of the material
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Abstract
Description
Claims (7)
- 카페익산을 유효성분으로 포함하며, 토포아이소머라아제 I 억제에 의한 혈액암 질환 예방 및 치료용 약학적 조성물.
- 제1항에 있어서,상기 카페익산은 어성초로부터 분리된 것을 특징으로 하는 혈액암 질환 예방 및 치료용 약학적 조성물.
- 어성초로부터 분리된 카페익산이 혈액암의 세포사멸을 유도하는 것을 특징으로 하는 혈액암 질환 예방 및 치료용 약학적 조성물.
- 제1항 내지 제3항 중 어느 한 항에 있어서,상기 혈액암 질환은 골수성 백혈병인 것을 특징으로 하는 혈액암 질환 예방 및 치료용 약학적 조성물.
- 제3항에 있어서,상기 카페익산은 어성초를 메탄올로 추출하여 1차 추출물을 얻고, 상기 1차 추출물을 다시 증류수와 부탄올 혼합용매에 용해한 후, 부탄올층을 건조하여 2차 추출물을 얻고, 상기 2차 추출물을 헥산과 에틸아세테이트 혼합 추출용매로 크로마토그래프하여 수득되는 것을 특징으로 하는 혈액암 질환 예방 및 치료용 약학적 조성물.
- 어성초로부터 분리된 카페익산을 유효성분으로 포함하는 것을 특징으로 하는 혈액암 질환 예방 건강식품.
- 제6항에 있어서,상기 카페익산은 어성초를 메탄올로 추출하여 1차 추출물을 얻고, 상기 1차 추출물을 다시 증류수와 부탄올 혼합용매에 용해한 후, 부탄올층을 건조하여 2차 추출물을 얻고, 상기 2차 추출물을 헥산과 에틸아세테이트 혼합 추출용매로 크로마토그래프하여 수득되는 것을 특징으로 하는 혈액암 질환 예방 건강식품.
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