KR101052092B1 - Cosmetic composition containing herbal extracts and extraction method thereof - Google Patents

Abstract

The present invention relates to a cosmetic composition containing a herbal extract and a method for extracting the same, in particular, a herbal medicine mixing step of forming a herbal medicine mixture by mixing a hawthorn tree, casualty, Hojanggun, Hagocho, sculpture; It comprises a herbal medicine extraction step of extracting the herbal medicine extract through the heating or dipping process by adding the extraction solvent to the herbal medicine mixture formed through the herbal medicine mixing step.

The present invention is the first, to prevent the inflammatory action and skin irritation that may occur on the skin by extracting the herbal medicine mixture mixed with hawthorn tree, casualties, Ho Jang Keun, Hagocho, sculpture with an extraction solvent to produce a cosmetic composition, The balance of oil and moisture can be achieved to improve moist skin.

Second, arachidonic acid, one of the essential fatty acids, can block the reaction pathways that interact with cyclooxygenase and lipoxygenase, which can cause skin irritation, and prevent skin inflammation from worsening. Even after this occurs, it can achieve a skin beauty effect to improve the skin trouble.

Third, by providing a cosmetic composition containing the herbal extracts obtained through the herbal medicine extraction step to prevent skin side effects that can occur when using the existing steroid-containing products to remove inflammation of the skin safely and conveniently Can be used.

Fourth, it can be used without skin side effects due to skin irritation of the human body, so as to ensure the reliability of consumers, it can be applied to the skin of patients with various skin diseases smoothly, as well as the cosmetic industry and the pharmaceutical industry that applied it. It can be applied to a wide range of applications.

Arachidonic acid, cyclooxygenase, lipoxygenase

Description

Cosmetic compositions containing herbal extracts and extracting method {Cosmetics compositions with herbal extracts and method for extracting the same}

The present invention relates to a cosmetic composition containing a herbal extract and a method for extracting the same, and more specifically, extracts from the herbaceous extract, a mixture of hawthorn, casualties, Hojanggun, Hagocho, sculpture through the extraction solvent containing the herbal extract The present invention relates to a cosmetic composition containing a herbal extract that can prevent and improve skin inflammation while preventing skin trouble by minimizing skin irritation by preparing a cosmetic composition, and a method of extracting the same.

In general, a typical irritant of the skin is ultraviolet rays, which act to continuously cause photochemical reactions on the skin.

The main cause of skin cell damage caused by UV rays is the singlet oxygen, which is the most reactive among various free radicals. It can cause.

As described above, the skin of the human body promotes skin aging and dermatitis through contact with various environments and substances as well as ultraviolet rays.

For example, dermatitis includes complex symptoms such as permeation of small arteries, capillaries and predetermined veins, dilation with increased blood flow, exudation of plasma containing plasma proteins, and migration of leukocytes to inflammatory sites.

In addition, there are physical factors such as trauma, injuries, frostbite, radioactivity, chemical factors such as acids, and immunological factors due to antibody reactions. Skin inflammation can also be caused by blood vessels or hormonal imbalances. It is.

As described above, in order to treat dermatitis caused by various pathways, non-steroidal systems include flufenamic acid, ibuprofen, benzydamine, and indomethacin. In addition, steroids such as prednisolone and dexamethasone are known to be effective in treating skin inflammation.

However, nonsteroidal flufenamic acid, ibuprofen, benzidamine, indomethacin, and arachidonic acid, a kind of fatty acid, are cyclooxygenase and When reacting with lipoxygenase to produce inflammatory cytotoxins (LT, PG), it is possible to block the biosynthesis-inducing agent that reacts with the cyclooxygenase, but it is an inflammatory-inducing substance generated by reaction with the lipoxygenase There was a problem that can not block the skin inflammation treatment effect is falling.

In addition, to improve the above problems, such as prednisolone (dexdnthathasone) and dexamethasone (dexamethasone) to limit the arachidonic acid (arachidonic acid) to react with lipoxygenase as well as to cause skin irritation In the case of using the drug of the Loit system, as a side effect of the steroid drug, as well as skin problems, there was a problem that can cause various side effects in the human body.

An object of the present invention is to solve the problems of the prior art described above, after forming a herbal medicine mixture by mixing a hawthorn tree, casualties, Hojang-gun, Hagocho, sculpture and then the herbal medicine through the process of extracting the herbal medicine extract with an extraction solvent The present invention provides a cosmetic composition containing an herbal extract that can cure skin inflammation smoothly while minimizing skin irritation even when used in the treatment of inflammation of the skin by preparing a cosmetic composition containing an extract and a method of extracting the same.

In addition, another object of the present invention is to minimize the skin irritation of the human body even when used in the treatment of skin inflammation, so that the user can use without skin side effects to ensure the consumer's reliability, the cosmetic industry and the pharmaceutical industry It is to provide a cosmetic composition containing the herbal extracts that can be widely applied to Edo and extraction methods thereof.

In order to achieve the above object, the present invention, herbal medicine mixing step of forming a herbal medicine mixture by mixing a hawthorn tree, casualties, Hojang-gun, Hagocho, sculpture; It comprises a herbal medicine extraction step of extracting the herbal medicine extract through the heating or dipping process by adding the extraction solvent to the herbal medicine mixture formed through the herbal medicine mixing step.

At this time, the content of the hawthorn tree, casualties, Hojang-gun, Hagocho, crude in the herbal medicine mixing step is 10-30% by weight, 10-30% by weight, casualties 10% to 30% by weight relative to the total 100% by weight of the herbal mixture before extraction General 10-30% by weight, hachocho 10-30% by weight, may be mixed in a proportion of 10-30% by weight engraver.

In addition, in the herbal medicine mixing step 100, the mixing ratio of the hawthorn tree, casualties, Hojang-gun, Hagocho, sculpture may be mixed in a 1: 2: 1: 1: 1.

In addition, in the herbal medicine extraction step, the extraction solvent may be made of any one or more selected from water, methanol, glycerin, butylene glycol, propylene glycol.

In addition, the extraction ratio of the extraction solvent added to the herbal medicine mixture in the herbal medicine extraction step may be added 1 to 20 parts by weight of the extraction solvent per 1 part by weight of the herbal medicine mixture.

In addition, the herbal medicine extraction step is a cooling capacitor is installed in the state to prevent the extraction solvent is evaporated to maintain the temperature of 40 ~ 100 ℃ to extract the herbal medicine extract by heating for 2 to 20 hours, the herbal medicine extraction step Maintaining the temperature of 4 ~ 40 ℃ can extract the herbal medicine extract by dipping the herbal medicine mixture in the extraction solvent for 1 to 15 days.

In addition, the present invention provides a cosmetic composition containing a herbal extract, including the herb extract, extracted from the tree, casualty, Hojanggun, Hagocho, sculptor.

At this time, the mixing ratio of the hawthorn tree, casualty, Hojang-gun, Hagocho, sculpture to form the herbal extracts may be made by mixing 10 to 30% by weight with respect to a total of 100% by weight.

In addition, the cosmetic composition prepared by containing the herbal extract may be made by containing 1 to 30% by weight of the herbal extract content based on 100% by weight of the total cosmetic composition.

In addition, it is preferable that the cosmetic composition prepared by containing the herbal extract has any one selected from skins, lotions, nutrient lotions, massage creams, basic cosmetics, and color cosmetics.

In particular, the cosmetic composition may be used for anti-inflammatory and skin irritation relief, and the cosmetic composition blocks the reaction with cyclooxygenase and lipoxygenase that cause inflammation by reacting with arachidonic acid, an essential fatty acid. Can be used to

The present invention as described above can obtain the following effects.

The present invention as described above, First, by extracting the herbal medicine mixture mixed with a hawthorn tree, casualty, Ho Jang-geun, hachicho, sculpture with an extraction solvent to prepare a cosmetic composition to prevent inflammation and skin irritation that may occur on the skin, The balance of oil and moisture can be achieved to improve moist skin.

Second, arachidonic acid, one of the essential fatty acids, can block the reaction pathways that interact with cyclooxygenase and lipoxygenase, which can cause skin irritation, and prevent skin inflammation from worsening. Even after this occurs, it can achieve a skin beauty effect to improve the skin trouble.

Third, by providing a cosmetic composition containing herbal medicine extract obtained through the herbal medicine extracting step to prevent skin side effects that may occur when using a conventional steroid-containing product to remove inflammation of the skin, safe and convenient Can be used.

Fourth, it can be used without skin side effects due to skin irritation of the human body, so as to secure the consumer's reliability, it can be applied smoothly to the skin of patients with various skin diseases, as well as the cosmetic industry and the pharmaceutical industry that apply it. It can be applied to a wide range of applications.

Specific features and other advantages of the present invention will become more apparent from the following drawings and description of the preferred embodiments.

Prior to describing the present description, the inventors of the present invention to prepare a cosmetic composition by extracting the extract with a solution after mixing the hawthorn tree, casualties, Ho Jang Keun, Hagocho, sculpture in order to minimize the irritation to the skin while smoothly treating skin inflammation By doing so, it is to propose a cosmetic composition and extracting method containing a herbal extract that can be conveniently used without side effects.

In addition, the present invention proposes a cosmetic composition and extract method containing the herbal medicine extract of the present invention to newly apply to the anti-inflammatory and irritation relief by investigating new natural ingredients in addition to various natural ingredients for anti-inflammatory and skin irritation relief used in the existing cosmetic composition It is done.

The present invention, as shown in Figure 1, herbal medicine mixing step (100) to form a herbal medicine mixture by mixing a hawthorn tree, casualties, Hojang-gun, Hagocho, sculpture; It comprises a herbal medicine extraction step 200 to extract the herbal medicine extract through the heating or immersion process by adding an extraction solvent to the herbal medicine mixture formed through the herbal medicine mixing step 100.

1) herbal medicine mixing step (100)

The step is 10 to 30% by weight, 10 to 30% by weight, 10 to 30% by weight, 10 to 30% by weight of Hoja-gun, 10 to 30% by weight of 100% by weight of 100% by weight It is to mix at a ratio of 10% by weight to 30% by weight, engraver.

The mixing ratio of the hawthorn tree, casualties, Hojang-gun, Hagocho, sculpture is less than 10% by weight of any one of the herbal medicines mixing ratio described above does not contain the ingredients of the medicinal herbs in the cosmetics enough to have the effect of skin inflammation and improvement There is a problem that can fall,

On the contrary, when any one of the above-described herbal medicine mixing ratio exceeds 30% by weight, the mixing ratio of the other herbal medicines is relatively lowered. Since the improvement effect may be reduced, as described above, the mixing ratio of the herbaceous trees, casualties, Hojanggun, Hagocho, and sculptural herbs is mixed 10 to 30% by weight, 10 to 30% by weight 10% to 30% by weight of Hojang group, 10-30% by weight of Hachocho, and 10 to 30% by weight of flakes are mixed.

In addition, even in the case as described above in the present invention, it is most preferable that the mixing ratio of the hawthorn tree, casualty, Hojang-gun, hachicho, sculpture is mixed in a 1: 2: 1: 1: 1.

This is applied in order to reduce skin irritation and achieve skin inflammation most smoothly when extracting the herbal medicine with an extract solution to form a cosmetic composition. It varies depending on the working environment or the skin condition of the operator to be applied. Of course, it can be changed and applied.

Looking at the pharmacological effect of the tree, casualty, Hojanggun, Hagocho, sculptor applied to the present invention.

Damnacanthus indicus is distributed in Korea (Hongdo, Jeju Island), Japan, China, and Nanjido, India. Growing in the woods as an evergreen shrub of the nectar family. It is 1m high, its branches spread out, and have short hairs. In the place of the leaves, branches come out that are similar in length to the leaves. The leaves have short stems and face each other. The broad egg shape is oval. It is also shiny and has a flat edge. Flowers bloom in June and hang 1 to 2 on axillas and white. Calyx is short, corolla is tubular, and its tip is divided into four. There are 4 stamens and the berry is round, ripened 5 ~ 7mm in diameter, and remains red until winter.

In addition, Hoja trees are used for ornamental purposes, or in the tropics, they are planted under large trees or grown in pots. The whole plant (outpost) or root of the tree or crystal tree is called 호 花, and the flower is called 복 花. The root of the crystal tree contains various kinds of anthraquinone, damnacanthal, damnacanthol, damnidin, juzunal, nordamnacanthal, norjuzunal, 2-benzylxanthopurpurin, alizarin-1-methylester and 5-hydroxyalizarin-1-methyl ether. Efficacy in 祛風 (거), 利 濕 (Damp), 活血 (Blood Blood), 소 (Small), 痛風 (Gout), 風濕 痺痛 (Truck) It is known to be effective in (pulmonary), 水腫 (severe), (infertility), jaundice, gynecological menopause, 小兒 疳 積 (child sensitization), main margin, bruises.

The casualty (Torilis japonica) resembles a bee box, but has threads and thin hairs on the stems and small spiny hairs on the fruit. Growing in the foothills and fields of various regions, the fruit contains 1.4% of essential oils. The main components are α-candinene and toylene C ₁₅ H ₂₄ . Oil is about 10%, mainly petroleum, myristic and olein. It has been used as a genital disease in the treatment of sinus. It is known as astringent anti-inflammatory medicine to eliminate vaginitis and mucus secretions of women, and it is used for leprosy and itching. It is also known to wash various skin wounds and is effective for hemorrhoids, and is used as a tonic for infertility and stomach ache. Written, 1999, 524--525, 535)

Reynoutria japonica Houtt. Is the root of perennial herbaceous perennial herb that is 1-2m in height. It is distributed in Korea, Japan, Taiwan, and China, and grows in mountainous areas. The main ingredient is glycoside polygonine C ₂₁ H ₂₀ O ₁₀ . Polygonins, when hydrolyzed, form ememodine and undiscovered sugars. Other examples include polymodin, emidein, monomethyl ether, and chrysophanol. In the green roots there is a reduced form of anthrone corresponding to the above anthraquinone compound. It is known to be used for dysmenorrhea, cystitis, jaundice and pleurisy. (Ingredients and Uses of Medicinal Herbs, Janwolseo, 1999, 205)

Prunella vulgaris L. var. Lilacina Nakai is a perennial herb 30-30 cm high. The leaves are long oval or long oval and opposite. The top of the stem forms a flower about 6cm long, and small branch flowers bloom in May-June and wither in summer. Breeds with seeds and roots, and grows in foothills, fields, roads, and wet places around the country. The outpost contains rutin, hyperside, and triterpensaponin (uroleic acid and its glycosides prunelin). 0.56% ursolic acid is obtained from the leaves and 0.5% essential oil from the flowers. The essential oil was camphor (about 50%), Fencon. There are also triterpenoids, glycosides, flavonoids, prunelin, bitter substances, resins, 0.98% tannins, alkaloids, 30mg% ascorbic acid, 6mg% carotene, vitamin K. About 3.5% of the minerals released into the water, of which 68% are potassium salts. In the private sector, decoctions are used to treat decoctions of the upper respiratory tract, including tonsillitis and tonsillitis, and to wash skin tuberculosis, adenopathy, swelling, flower buds, dermatitis and hair dandruff with decoction. (Ingredient and use of medicinal herbs, January and West writing, 1999, 601-602)

The sculptor (Gleditsia japonica Miquel var.) Is a thorn of a juniper tree up to 12 m high. It grows in the foothills, valleys, and streams of 100 ~ 900m above sea level except Hamgyongbuk-do. Ingredients include alkaloids in young stems, leaves, berries and seeds. Most of the alkaloids are triacanthins and contain small amounts of alkaloids that have not yet been identified. Triacanthin C ₁₀ H ₁₃ N ₅ has a melting point of 228 ℃, optically inert, freed from alcohol, freed from water, ether, and benzene. It is known to be descending. (Ingredients and Uses of Medicinal Herbs, Janwol Seokji, 1999, 376-378)

2) Herbal Medicine Extraction Stage (200)

The step is to extract the herbal medicine extract through the heating or dipping process by adding the extraction solvent to the herbal medicine mixture mixed through the herbal medicine mixing step 100.

That is, to extract the useful components of the above-mentioned hawthorn tree, casualty, Hojang-geun, hachicho, sculptor, in the present invention, the herbal mixture of the hawthorn, casualty, Hojang-gun, hachicho, sculptor is water, methanol, The herbal medicine mixture mixed through the herbal medicine mixing step 100 is extracted through at least one extraction solvent selected from glycerin, butylene glycol, and propylene glycol.

At this time, the addition of any one or more extraction solvent selected from the water, methanol, glycerin, butylene glycol, propylene glycol added to the herbaceous wood, casualties, Hojang-gun, Hagocho, sculptural herbal medicine mixture per 1 part by weight of the herbal medicine mixture 1 to 20 parts by weight of the extraction solvent is added.

As such, by adding an extraction solvent to the herbal medicine mixture, the herbal medicine extract is extracted in the present invention through the following heating or deposition process.

For example, the herbaceous tree, casualty, Hojang-gun, Hagocho, sculptural herbal mixtures are extracted through any one or more extraction solvents selected from water, methanol, glycerin, butylene glycol, propylene glycol, cooling condenser is extracted Maintaining a temperature of 40 ~ 100 ℃ in the state of preventing the solvent from evaporating it can be heated for 2 to 20 hours to extract the herbal medicine extract.

In addition, the extract of the medicinal herb mixture of the hawthorn tree, casualties, Hojanggun, Hagocho, sculpture is extracted through any one or more extraction solvents selected from water, methanol, glycerin, butylene glycol, propylene glycol, and the temperature of 4 ~ 40 ℃ The herbal medicine extract may be extracted by keeping the herbal medicine mixture in one or more selected extraction solvents for 1 to 15 days.

Extracting the herbal medicine extract through the heating or dipping process is a preferred method, but in the above heating process, when the extraction temperature drops below 40 ° C or exceeds 100 ° C, or when the heating time is below 2 hours Falling or exceeding 20 hours does not change the extraction effect of the herbal medicine extract, but there is a problem that the process of extracting the herbal medicine extract may not be made smoothly, as described above, by maintaining the temperature of 40 ~ 100 ℃ 2 ~ It is preferable to extract the herbal medicine extract from the herbal medicine mixture by heating for 20 hours.

In addition, in the case of extracting the herbal medicine extract through the immersion process, as described above, performing the immersion process for 1 to 15 days by maintaining the temperature of 4 ~ 40 ℃ in the case of proceeding the immersion process out of the above conditions The extraction process may not be made smoothly, and the extraction effect of the herbal medicine extract does not change, so to maintain the temperature of 4 ~ 40 ℃ as described above to perform the immersion process for 1 to 15 days to extract the herbal medicine extract smoothly But the extraction process can be made smoothly without taking a long time.

Hereinafter, the present invention will be described in detail with reference to Examples, Experimental Examples, Prescription Examples, Formulation Examples, etc. in order to explain the present invention in detail.

At this time, embodiments of the present invention, experimental examples, prescription examples, formulation examples, etc. may be variously changed and provided to enable more clear implementation of the present invention is not limited thereto and can be applied in various changes. .

[Examples 1-15]

100g, 100g, 100g, 100g, 100g, 100g flakes of 100 g of Jaja tree were added as 10 times the amount of 70% functional ethanol as shown in the following [Table 1], and extracted at room temperature for 5 days through an extractor, followed by 400mesh Filtration with a filter cloth and filtered with a filter of 0.45㎛ could obtain the result as shown in [Table 1].

TABLE 1

[Examples 18-20]

100g, 200g, 100g, 100g, 100g, 200g, 100g flakes were added 5kg using the extraction solvent shown in Table 2, 400mg filter cloth after extracting the herbal medicine mixture through the extractor at room temperature for 5 days Filtered through a filter of 0.45㎛ was obtained as shown in the following [Table 2].

TABLE 2

[Example 23]

100 g of saponifera, 200 g of casualty, 100 g of knotweed, 200 g of red pepper, and 100 g of flakes were placed in 5 kg of 30% hydrous butylene glycol and heated at 80 ° C. for 3 hours while the cooling condenser was installed to prevent the solvent from evaporating. After filtering with a 400mesh filter cloth and filtered with a filter of 0.45 ㎛ was obtained 3.5kg herbal extract.

[Examples 24-28]

By applying the extraction solvent as shown in Table 3 below and extracting the herbal medicine mixture in the same manner as in Example 15 it was possible to obtain the results as shown in Table 3.

[Table 3]

Experimental Example 1

In order to confirm the inhibitory effect of the lipidase activity in Examples [1 ~ 28] of the mixed extract was tested as follows.

50 μl of a sample of 0.95 mL of Lipoxydase solution in 50,000 units / mL in a 1.0 mL solution of 1.12 mM linolenic acid dissolved in 0.1 M sodium phosphate buffer (pH 7.0) Was added and reacted at 25 ° C for 10 minutes.

Sample as a control Solvent is used instead. Blank blank is added with 0.95 mL of buffer instead of lipoxidase solution. Thereafter, 0.5 mL of 20% trichloroacetic acid and 1.0 mL of 0.6% thiobarbituric acid were added, followed by heating and color development in boiling water for 10 minutes and cooling in ice water.

Then, 2.0 mL of butanol was added and stirred, followed by centrifugation. The upper layer butanol was measured for absorbance at 535 nm using a spectrophotometer (UV Spectrum).

Each sample was carried out with the final concentration of the reaction solution 500 ㎍ / ㎖, 1,000 ㎍ / ㎖, the inhibition rate for the enzyme activity was calculated by the following [Equation 1]. As a result of the experiment, Examples 11 and 16 to 28 showed a high inhibition rate of 50% or more (see Table 4).

[Equation 1]

% Inhibition = {1-(experimental group-blank) / control} × 100

[Table 4]

Inhibitory effect of lipoxidase activity

Experimental Example 2 Anti-inflammatory Experiment

In order to examine the anti-inflammatory effects of the herbal extracts according to the present invention, the left and right ears were set as the control site and the right ear as the test site, and both ears were washed thoroughly with ethanol before applying the sample. It is applied once a day for 4 days. After 1 hour of last application, ethanol is applied to the left ear and arachidonic acid is applied 2mg / ear to the right ear. After 1 hour, the degree of ear edema is micrometer. Both ears were repeatedly measured three times.

Accordingly, the degree of inhibition of edema was determined based on the arachidonic acid treatment group, and the results as shown in Table 5 below were obtained.

TABLE 5

Ear thickness and inflammation inhibition rate by topical application

% Inhibition = (A-B) / A × 100

A: Average thickness of control ears (thickness of arachidonic acid treated ears-thickness of untreated ears)

B: Thickness of the sample coated group ears (thickness of arachidonic acid treated ears-thickness of untreated ears)

As shown in [Experimental Example 1] and [Experimental Example 2], as well as inhibiting the activation of dermatitis, it also inhibits the smooth biosynthesis of lipoxidase in response to arachidonic acid (arachidonic acid) It was found that the skin inflammation can be smoothly improved without skin irritation.

Hereinafter, the prescription example according to the above-described experimental example.

[Prescription 1]

Prescription example of a lotion (skin lotion) in the cosmetic containing the extract of Example 23 is as follows.

<Manufacturing Method>

Formulation Example 1 2, 3, 4, 5 times in 11 in order to dissolve by stirring, and then 5 times to dissolve by heating about 60 ℃. Input 10 times and stir to 11 times. And finally, 1, 6, 7, and 9 times put into the stirring process after aging.

<Manufacturing Method of Another Example according to Formulation Example 1>

Comparative Formulation Example 1 No. 2, 3, 4, and 8 were added sequentially in order to dissolve with stirring, and then, No. 5 was heated and dissolved at about 60 ° C., followed by 10 times of stirring and input into No. 11. . And finally, 6, 7, and 9 times put into the stirring process after aging.

[Prescription 2]

Prescription example of nutrition lotion in the cosmetic composition containing the extract of Example 23 is as follows.

<Manufacturing Method>

Formulation Example 2: The raw materials 2,3,4,5 and 6 are homogenized at a constant temperature to be referred to as bioionic amphiphilic lipids.

After mixing the bio-based amphiphilic lipid and the raw materials 1,7,8 and 14 and homogenizing at a constant temperature, and homogenizing by gradually adding the raw material 9 at a constant temperature, 10,11,12,13, Disperse, stabilize and mature.

<Manufacturing Method of Another Example according to Formulation Example 2>

Comparative Formulation Example 2 The raw materials 2,3,4,5 and 6 were homogenized at a constant temperature to be referred to as bion-based amphiphilic lipids.

The bio-based amphiphilic lipid and the raw materials 7,8 and 14 are mixed and homogenized at a constant temperature, and the raw material 9 is gradually added and homogenized at a constant temperature, and then stabilized by adding 10,11,12,13 And matured.

[Prescription 3]

Prescription example of nutrition cream in the cosmetic composition containing the extract of Example 23 is as follows.

<Manufacturing Method>

Formulation Example 3 The raw materials 2,3,4,5 and 6 are homogenized at a constant temperature to be referred to as a bioionic amphiphilic lipid.

The bio-based amphiphilic lipid and the raw materials 1,7,8 and 14 are mixed and homogenized at a constant temperature, and the raw material 9 is gradually added and homogenized at a constant temperature, and then 10,11,12,13 is added and dispersed. Stabilize and age.

<Manufacturing Method of Another Example according to Formulation Example 3>

Comparative Formulation Example 3 The raw materials 2,3,4,5 and 6 were homogenized at a constant temperature to be referred to as a bioionic amphiphilic lipid.

The bion-based amphiphilic lipid and the raw materials 7,8 and 14 are mixed and homogenized at a constant temperature, and the raw material 9 is gradually added and homogenized at a constant temperature, and then stabilized by adding 10,11,12,13. Mature.

[Prescription 4]

Prescription example of massage cream in the cosmetic composition containing the extract of Example 23 is as follows.

<Manufacturing Method>

Formulation Example 4 8,9,10,11,13,16 while stirring and mixing to a temperature of 80 ~ 85 ℃ to put into the manufacturing unit and then actuated emulsifier 2,3,4,5,6,7, 12 was heated to 80 ~ 85 ℃ to emulsify.

After the emulsification is finished using a stirrer to cool to 50 ℃ and then put 14 times, and then cooled to 45 ℃ and 15 times, and when the cooling to 35 ℃ 1 is added. Then, the mixture is cooled to 25 ° C. and aged.

<Production Method of Another Example according to Formula 4>

Comparative Formulation Example 4 The mixture was stirred at 8, 9, 10, 11, 13, and 16, heated to a temperature of 80 to 85 ° C., introduced into the manufacturing unit, and then the emulsifier was operated. 2, 3, 4, 5, 6, 7 , 12 was heated to 80 ~ 85 ℃ and emulsified.

After the saik emulsification is finished using a stirrer, the mixture is cooled to 50 ° C., added 14 times, cooled to 45 ° C. again, added 15 times, cooled to 35 ° C., and aged.

Test examples carried out based on the formulation and formulation examples as described above are as follows.

[Test Example 1]

Experiments regarding the skin irritation effect of Formulation Examples 1 to 4 and Comparative Formulation Examples 1 to 4 in Formulation Examples 1 to 4 were measured as follows.

Formulation and Sodium Lauryl Sulfate 0.08% aqueous solution was applied to 20 healthy males and females, and a certain amount (0.2 g) of each sample was applied to the back area for 24 hours, and the pin chamber was removed for 4 hours. The change was read and the results are shown in Table 11.

* Skin irritation test result

※ Criteria-: No erythema or unusual phenomenon

            +-: Slightly reddish

            +: Significantly redder than the surroundings

            ++: Severe reddening and swelling around

Stimulus degree = {(+-) number × 1} + {(+) number × 2} + {(++) number × 3} / number of subjects

As described above, the present invention appears to have the advantage of smoothly improving the skin inflammation when the skin is continuously applied to the inflamed site while minimizing the skin irritation.

In addition, cyclooxygenase, which can be biosynthesized with arachidonic acid (arachidonic acid) to cause skin inflammation, also inhibits the biosynthesis of lipoxydase, making it safe without skin trouble without using conventional steroidal drugs. There is an advantage that can be used conveniently.

While the invention has been shown and described with respect to specific embodiments thereof, it will be appreciated that the invention can be variously modified and varied without departing from the spirit or scope of the invention as provided by the following claims. It will be obvious to those of ordinary skill.

1 is a process flow chart of the cosmetic composition containing the herbal extract according to the present invention and its extraction method.

         <Code Description of Main Parts of Drawing>

 100: herbal medicine mixing step 200: herbal medicine extraction step

Claims (13)

Chinese herbal medicine mixing step (100) to form a herbal medicine mixture by mixing a tree, casualties, Hojanggun, Hagocho, sculptor; Cosmetics containing a herbal medicine extract, characterized in that it comprises a herbal medicine extract step (200) for extracting the herbal medicine extract through a heating or dipping process by adding an extraction solvent to the herbal medicine mixture formed through the herbal medicine mixing step (100) Method for preparing the composition. The method according to claim 1, In the herbal medicine mixing step (100) The content of Hoja tree, casualty, Hojang-gun, Hagocho, sculpture is 10-30% by weight, 10-30% by weight, 10-30% by weight, Hojang-gun, 100% by weight, based on 100% by weight of the total herbal mixture before extraction. Ultra 10 to 30% by weight, medicinal herb extracts containing a method for producing a cosmetic composition, characterized in that the mixture is mixed in a proportion of 10 to 30% by weight. The method according to claim 1, In the herbal medicine mixing step (100) Method of producing a cosmetic composition containing the herbal extract, characterized in that the mixing ratio of the hawthorn tree, casualties, Hojang-gun, Hagocho, sculpture is 1: 2: 1: 2: 1. The method according to claim 1, In the herbal medicine extraction step 200 The extracting solvent is water, methanol, glycerin, butylene glycol, propylene glycol medicinal herb extract containing cosmetic composition, characterized in that consisting of at least one selected from propylene glycol. The method according to claim 1, In the herbal medicine extraction step 200 The addition ratio of the extraction solvent added to the herbal medicine mixture is a cosmetic composition containing the herbal medicine extract, characterized in that 1 to 20 parts by weight of the extraction solvent is added per 1 part by weight of the herbal medicine mixture. The method according to claim 1, The herbal medicine extraction step 200 A method of manufacturing a cosmetic composition containing a herbal extract, characterized in that to extract the herbal extract by heating for 2 to 20 hours while maintaining a temperature of 40 ~ 100 ℃ in a state that the cooling capacitor is installed to prevent the extraction solvent to evaporate. The method according to claim 1, The herbal medicine extraction step 200 Maintaining the temperature of 4 ~ 40 ℃ 1 to 15 days by distilling the herbal medicine mixture in the extraction solvent to extract the herbal medicine extract, characterized in that the cosmetic composition containing a herbal composition extract. A cosmetic composition containing a herbal extract, characterized in that it comprises a herbal extract extracted from a mixture of hawthorn tree, casualty, Hojanggun, Hagocho and flakes. The method according to claim 8, The mixing ratio of the hawthorn tree, casualty, Hojang-gun, Hagocho, flakes to form the herbal extracts is a cosmetic composition containing herbal extracts, characterized in that 10 to 30% by weight based on a total of 100% by weight. The method according to claim 8, Cosmetic composition prepared by containing the herbal extract is a cosmetic composition containing a herbal extract, characterized in that the content of the herbal extract is 1 to 30% by weight based on 100% by weight of the total cosmetic composition. The method according to claim 8, The cosmetic composition prepared by containing the herbal extracts is a cosmetic composition containing a herbal extract, characterized in that it has any one selected from skins, lotions, nutrition lotions, massage creams, basic cosmetics and color cosmetics. The method according to any one of claims 8 to 11, The cosmetic composition is a cosmetic composition containing a herbal extract, characterized in that used for anti-inflammatory and skin irritation relief. The method according to claim 8, The cosmetic composition is a cosmetic composition containing a herbal extract, characterized in that it is used to block the reaction with the cyclooxygenase and lipoxygenase causing inflammation by reacting with arachidonic acid which is an essential fatty acid.

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