KR100983450B1 - 식품보충제에 대한 개별적 다양성 평가의 모델로서 전혈내의 생체 외 유전자 발현 - Google Patents

식품보충제에 대한 개별적 다양성 평가의 모델로서 전혈내의 생체 외 유전자 발현 Download PDF

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KR100983450B1
KR100983450B1 KR1020077027182A KR20077027182A KR100983450B1 KR 100983450 B1 KR100983450 B1 KR 100983450B1 KR 1020077027182 A KR1020077027182 A KR 1020077027182A KR 20077027182 A KR20077027182 A KR 20077027182A KR 100983450 B1 KR100983450 B1 KR 100983450B1
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whole blood
mrna
vitamin
blood
exposed
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KR20080019590A (ko
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마사토 미츠하시
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히다치 가세고교 가부시끼가이샤
히타치케미컬 리서치센터 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
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    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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KR1020077027182A 2005-04-28 2006-04-28 식품보충제에 대한 개별적 다양성 평가의 모델로서 전혈내의 생체 외 유전자 발현 Expired - Fee Related KR100983450B1 (ko)

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US67558005P 2005-04-28 2005-04-28
US60/675,580 2005-04-28

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KR20080019590A KR20080019590A (ko) 2008-03-04
KR100983450B1 true KR100983450B1 (ko) 2010-09-20

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US (1) US20080206761A1 (enExample)
EP (1) EP1888089B9 (enExample)
JP (1) JP4945554B2 (enExample)
KR (1) KR100983450B1 (enExample)
CN (1) CN101166537B (enExample)
AT (1) ATE512234T1 (enExample)
WO (1) WO2006116721A1 (enExample)

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CN101426930A (zh) * 2004-05-25 2009-05-06 日立化成工业株式会社 检测癌症易感性的方法
EP1802776B1 (en) * 2004-10-20 2013-01-02 Hitachi Chemical Company, Ltd. Method for tailoring administration of drugs by quantitation of mrna
ATE510929T1 (de) * 2005-06-08 2011-06-15 Hitachi Chemical Res Ct Inc Verfahren zur vorhersage einer immunantwort auf eine tumorerkrankung auf der grundlage eines mrna-expressionsprofils in tumorzellen und stimulierten leukozyten
WO2007117589A2 (en) * 2006-04-07 2007-10-18 Hitachi Chemical Co., Ltd. Enhanced fc receptor-mediated tumor necrosis factor superfamily and chemokine mrna expression in peripheral blood leukocytes in patients with rheumatoid arthritis
EP2005175B1 (en) * 2006-04-07 2011-07-27 Hitachi Chemical Company, Ltd. Enhanced t cell receptor-mediated tumor necrosis factor superfamily and chemokine mrna expression in peripheral blood leukocytes in patients with crohn's disease
EP2015783A4 (en) * 2006-05-08 2010-07-21 Hitachi Chemical Co Ltd METHOD FOR TESTING THE SENSITIVITY OF A MEDICINAL PRODUCT IN SOLID TUMORS BY QUANTIFYING THE EXPRESSION OF mRNA IN THIN CUTS OF TUMOR TISSUE
EP2209919A4 (en) * 2007-11-14 2011-04-13 Hitachi Chemical Co Ltd ENHANCED EXPRESSION OF FC RECEPTOR TUMOR NECROSIS NECROSIS FACTOR SUPERFAMILY IN THE PERIFERIC BLOOD LEUKOCYTES
US20090215064A1 (en) * 2008-02-27 2009-08-27 Hitachi Chemical Co., Ltd. Quantitative assessment of individual cancer susceptibility by measuring dna damage-induced mrna in whole blood
WO2010062960A2 (en) 2008-11-26 2010-06-03 Cedars-Sinai Medical Center METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE
US9580752B2 (en) 2008-12-24 2017-02-28 Cedars-Sinai Medical Center Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy
JP2013528371A (ja) 2010-05-07 2013-07-11 日立化成株式会社 インターフェロン応答マーカーのエクスビボ誘導によるインターフェロンに対する宿主応答性を特徴づける方法
EP2734233B1 (en) * 2011-07-18 2017-11-01 Hitachi Chemical Co., Ltd. Methods of predicting host responsiveness to cancer immunotherapies by ex vivo induction of leukocyte-function-associated mrnas
US10633449B2 (en) 2013-03-27 2020-04-28 Cedars-Sinai Medical Center Treatment and reversal of fibrosis and inflammation by inhibition of the TL1A-DR3 signaling pathway
EP3022295A4 (en) 2013-07-19 2017-03-01 Cedars-Sinai Medical Center Signature of tl1a (tnfsf15) signaling pathway
US11028443B2 (en) 2015-08-31 2021-06-08 Showa Denko Materials Co., Ltd. Molecular methods for assessing urothelial disease
WO2017161342A1 (en) 2016-03-17 2017-09-21 Cedars-Sinai Medical Center Methods of diagnosing inflammatory bowel disease through rnaset2

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EP2209919A4 (en) * 2007-11-14 2011-04-13 Hitachi Chemical Co Ltd ENHANCED EXPRESSION OF FC RECEPTOR TUMOR NECROSIS NECROSIS FACTOR SUPERFAMILY IN THE PERIFERIC BLOOD LEUKOCYTES
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JP4945554B2 (ja) 2012-06-06
CN101166537A (zh) 2008-04-23
KR20080019590A (ko) 2008-03-04
EP1888089B9 (en) 2012-08-08
JP2008538930A (ja) 2008-11-13
WO2006116721A1 (en) 2006-11-02
EP1888089A1 (en) 2008-02-20
EP1888089B1 (en) 2011-06-08
ATE512234T1 (de) 2011-06-15
EP1888089A4 (en) 2009-01-07
US20080206761A1 (en) 2008-08-28
CN101166537B (zh) 2013-01-23

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