KR100946219B1 - 피롤로[3,2-ｃ]피리딘 유도체 및 그의 제조방법 - Google Patents

피롤로[3,2-ｃ]피리딘 유도체 및 그의 제조방법 Download PDF

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Publication number
KR100946219B1
KR100946219B1 KR1020050082008A KR20050082008A KR100946219B1 KR 100946219 B1 KR100946219 B1 KR 100946219B1 KR 1020050082008 A KR1020050082008 A KR 1020050082008A KR 20050082008 A KR20050082008 A KR 20050082008A KR 100946219 B1 KR100946219 B1 KR 100946219B1
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KR
South Korea
Prior art keywords
pyrrolo
pyridine hydrochloride
tetrahydroisoquinolin
dimethyl
benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020050082008A
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English (en)
Korean (ko)
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KR20060051002A (ko
Inventor
강희일
김재규
이혁우
윤석원
윤영애
김동훈
신영아
안병락
금세훈
최룡
Original Assignee
주식회사유한양행
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Publication date
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Publication of KR20060051002A publication Critical patent/KR20060051002A/ko
Application granted granted Critical
Publication of KR100946219B1 publication Critical patent/KR100946219B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020050082008A 2004-09-03 2005-09-03 피롤로[3,2-ｃ]피리딘 유도체 및 그의 제조방법 Expired - Fee Related KR100946219B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020040070536 2004-09-03
KR20040070536 2004-09-03

Publications (2)

Publication Number Publication Date
KR20060051002A KR20060051002A (ko) 2006-05-19
KR100946219B1 true KR100946219B1 (ko) 2010-03-08

Family

ID=36000316

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020050082008A Expired - Fee Related KR100946219B1 (ko) 2004-09-03 2005-09-03 피롤로[3,2-ｃ]피리딘 유도체 및 그의 제조방법

Country Status (16)

Country Link
US (2) US8148529B2 (https=)
EP (1) EP1784402B1 (https=)
JP (1) JP5126830B2 (https=)
KR (1) KR100946219B1 (https=)
CN (1) CN101018788B (https=)
AT (1) ATE518858T1 (https=)
AU (1) AU2005280738B2 (https=)
BR (1) BRPI0514843A (https=)
CA (1) CA2578880C (https=)
DK (1) DK1784402T3 (https=)
ES (1) ES2367312T3 (https=)
MX (1) MX2007002214A (https=)
PL (1) PL1784402T3 (https=)
PT (1) PT1784402E (https=)
RU (1) RU2378275C2 (https=)
WO (1) WO2006025714A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008017466A1 (en) * 2006-08-08 2008-02-14 Nycomed Gmbh Pharmaceutically active tetrahydroisoquinoline-substituted benzimidazole derivatives
EP2452680B1 (en) 2009-07-09 2019-12-18 RaQualia Pharma Inc. Acid pump antagonist for the treatment of diseases involved in abnormal gastrointestinal motility
TWI636047B (zh) 2013-08-14 2018-09-21 英商卡爾維斯塔製藥有限公司 雜環衍生物
GB2517908A (en) 2013-08-14 2015-03-11 Kalvista Pharmaceuticals Ltd Bicyclic inhibitors
CN103626767A (zh) * 2013-12-04 2014-03-12 上海药明康德新药开发有限公司 区域选择性的氮杂吲哚及其合成方法
GB201421083D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd Enzyme inhibitors
JP7511326B2 (ja) 2015-10-09 2024-07-05 ウェイブ ライフ サイエンシズ リミテッド オリゴヌクレオチド組成物およびその方法
IL263235B (en) 2016-05-31 2022-07-01 Kalvista Pharmaceuticals Ltd History of pyrazoles as plasma kallikrein inhibitors
GB201609607D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
GB201719881D0 (en) 2017-11-29 2018-01-10 Kalvista Pharmaceuticals Ltd Solid forms of plasma kallikrein inhibitor and salts thereof
HUE057912T2 (hu) 2017-11-29 2022-06-28 Kalvista Pharmaceuticals Ltd Plazma kallikrein inhibitort tartalmazó dózisformák
WO2021028645A1 (en) 2019-08-09 2021-02-18 Kalvista Pharmaceuticals Limited Plasma kallikrein inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998028322A1 (en) * 1996-12-20 1998-07-02 Schering Aktiengesellschaft Bissteroidal compounds and their use for the preparation of chiral complexes
WO2003009852A1 (en) 2001-07-24 2003-02-06 Merck & Co., Inc. Tyrosine kinase inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3269604D1 (en) 1981-06-26 1986-04-10 Schering Corp Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
JP3465827B2 (ja) * 1993-02-24 2003-11-10 株式会社日清製粉グループ本社 アザインドール誘導体およびこれを有効成分とする抗潰瘍薬
US5451566A (en) * 1993-11-17 1995-09-19 Zeneca Limited Herbicidal pyrrolopyridine compounds
ES2185693T3 (es) * 1994-01-19 2003-05-01 Sankyo Co Derivado de pirrolopiridacina.
JP2896532B2 (ja) 1994-08-13 1999-05-31 ユーハン コーポレーション 新規なピリミジン誘導体およびその製造方法
SE9700661D0 (sv) 1997-02-25 1997-02-25 Astra Ab New compounds
SE9704404D0 (sv) * 1997-11-28 1997-11-28 Astra Ab New compounds
TR200002182T2 (tr) * 1998-01-27 2000-12-21 Aventis Pharmaceuticals Products Inc. İkame edilmiş aksozaherosayklil faktör xa inhibitörleri
EE04677B1 (et) 1998-09-23 2006-08-15 Byk Gulden Lomberg Chemische Fabrik Gmbh Tetrahdropridoeetrid, nende kasutamine ja ravim
US20040110785A1 (en) * 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998028322A1 (en) * 1996-12-20 1998-07-02 Schering Aktiengesellschaft Bissteroidal compounds and their use for the preparation of chiral complexes
WO2003009852A1 (en) 2001-07-24 2003-02-06 Merck & Co., Inc. Tyrosine kinase inhibitors

Also Published As

Publication number Publication date
US8513277B2 (en) 2013-08-20
JP5126830B2 (ja) 2013-01-23
ATE518858T1 (de) 2011-08-15
JP2008511618A (ja) 2008-04-17
AU2005280738B2 (en) 2010-11-25
BRPI0514843A (pt) 2008-06-24
CA2578880A1 (en) 2006-03-09
US8148529B2 (en) 2012-04-03
RU2007112108A (ru) 2008-10-10
CN101018788B (zh) 2010-08-25
EP1784402A4 (en) 2009-12-23
EP1784402B1 (en) 2011-08-03
PT1784402E (pt) 2011-08-23
ES2367312T3 (es) 2011-11-02
US20090005409A1 (en) 2009-01-01
CN101018788A (zh) 2007-08-15
KR20060051002A (ko) 2006-05-19
AU2005280738A1 (en) 2006-03-09
DK1784402T3 (da) 2011-11-14
US20120065224A1 (en) 2012-03-15
MX2007002214A (es) 2007-05-07
HK1105977A1 (en) 2008-02-29
EP1784402A1 (en) 2007-05-16
WO2006025714A1 (en) 2006-03-09
PL1784402T3 (pl) 2011-12-30
CA2578880C (en) 2013-01-29
RU2378275C2 (ru) 2010-01-10

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