KR100918326B1 - 칠피, 건칠, 칠목 유래 알러지를 유발하지 않는 추출물 및이를 함유하는 약리학적 조성물 - Google Patents
칠피, 건칠, 칠목 유래 알러지를 유발하지 않는 추출물 및이를 함유하는 약리학적 조성물 Download PDFInfo
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- KR100918326B1 KR100918326B1 KR1020080036563A KR20080036563A KR100918326B1 KR 100918326 B1 KR100918326 B1 KR 100918326B1 KR 1020080036563 A KR1020080036563 A KR 1020080036563A KR 20080036563 A KR20080036563 A KR 20080036563A KR 100918326 B1 KR100918326 B1 KR 100918326B1
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- extract
- lacquer
- water
- cancer
- anticancer
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/302—Foods, ingredients or supplements having a functional effect on health having a modulating effect on age
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/304—Foods, ingredients or supplements having a functional effect on health having a modulation effect on allergy and risk of allergy
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/308—Foods, ingredients or supplements having a functional effect on health having an effect on cancer prevention
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
Description
우루시올 분자량 | 칠액 | 알칼리 처리전 농축액 | 본발명의 최종 추출물 분말 |
314 | 1.5%(w/w) | 0.3%(w/w) | 불검출 |
316 | 0.1%(w/w) | 0.03%(w/w) | 불검출 |
318 | 0.13%(w/w) | 0.1%(w/w) | 불검출 |
320 | 1.1%(w/w) | 0.12%(w/w) | 불검출 |
환자명 | 병명 | 몰핀투여횟수(회/일) | 추출물 투여농도(mg/day) | 추출물 투여 후 몰핀 투여 횟수(회/일) |
A | 위암 | 3 | 2,500 | 1 |
B | 대장암 | 2 | 3,000 | 0 |
C | 위암 | 2 | 2,800 | 0 |
D | 간암 | 3 | 3,200 | 0 |
E | 폐암 | 2 | 2,600 | 1 |
F | 췌장암 | 4 | 3,300 | 1 |
G | 유방암 | 1 | 1,900 | 0 |
우루시올 분자량 | 비교예의 추출물 | 본 발명의 추출물 |
314 | 0.25%(w/w) | 불검출 |
316 | 0.05%(w/w) | 불검출 |
318 | 0.1%(w/w) | 불검출 |
320 | 0.33%(w/w) | 불검출 |
암의 종류 | 균주명 | 암세포억제효과(%) |
결장암 | WiDr | 63 |
간암 | HEPG2 | 44 |
자궁암 | HeLa | 72 |
위암 | SNU-5 | 87 |
직장암 | SNU-1033 | 79 |
폐암 | Calu-3 | 82 |
시료명 | 50% 억제농도(ug/ml) |
비타민 E | 13.1 |
본발명의 추출물 | 18.0 |
옻나무 물추출물 | 33.1 |
푸스틴 | 1.8 |
피세틴 | 2.2 |
설푸레틴 | 3.5 |
시료 | 폐암 | 간암 | 방광암 | 림프종 | 신장암 | 백혈병 | 위암 |
대조군 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
본발명의 추출물 투여군 | 24 | 33 | 35 | 18 | 29 | 16 | 25 |
Claims (7)
- 옻나무 유래 추출물을 제조함에 있어,1) 옻나무 유래 한약재인 칠목, 칠피, 건칠을 무게비로 1:0.05~0.3:0.05~0.2의 비율로 혼합하고, 분말화하는 분말화 단계,2) 상기 분말에 물을 분말 무게의 5~20배수 가하고, 추출하고, 여과하여 물추출액을 얻는 물추출 단계,3) 물추출 단계에서 남은 박에 에탄올을 처음 원료무게의 5~10배수 가하고, 추출하여 에탄올 추출액을 얻는 에탄올 추출 단계,4) 상기 물 추출단계와 에탄올 추출단계에서 얻어진 추출액을 농축하여 고형분의 농도가 20~50%(w/v)가 되도록 하는 농축단계,5) 상기 농축 단계에서 얻어진 농축액에 pH 8.0~9.5의 알칼리수를 가하여 고형분의 농도가 5~40%(w/v)가 되도록 하고, 산소가 함유된 기체를 가하여 주면서 혼합, 처리하는 알칼리수 처리단계,를 포함하는 공정에 의하여 얻어지는 것을 특징으로 하는 옻나무 유래 추출물의 제조방법.
- 제 1항에 있어서 5)의 알칼리수 처리단계에서 산소를 함유한 기체로서 산소의 농도가 20~100%(v/v)인 것을 특징으로 하는 옻나무 유래 추출물의 제조방법.
- 제 1항에 있어서 5)의 알칼리수 처리단계에서 알칼리수를 만드는 방법으로서 전기분해방법 또는 가성소다, 수산화칼슘, 수산화마그네슘 으로 이루어지는 물질 중 한가지 이상을 첨가하여 제조하는 방법 중 한 가지를 이용하는 것을 특징으로 하는 옻나무 유래 추출물의 제조방법.
- 삭제
- 삭제
- 삭제
- 삭제
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KR1020070060490A KR20070077154A (ko) | 2007-06-20 | 2007-06-20 | 칠피, 건칠, 칠목 유래 알러지를 유발하지 않는 추출물 및이를 함유하는 약리학적 조성물 |
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KR1020080036563A KR100918326B1 (ko) | 2007-06-20 | 2008-04-21 | 칠피, 건칠, 칠목 유래 알러지를 유발하지 않는 추출물 및이를 함유하는 약리학적 조성물 |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012020892A1 (ko) | 2010-08-11 | 2012-02-16 | (주)에이지아이 | 활성형 플라보노이드 화합물의 함량이 증가된 옻나무 추출물 및 그의 제조 방법 |
KR20150130639A (ko) * | 2014-05-13 | 2015-11-24 | 주식회사한국야쿠르트 | 사과박(apple pomace)으로부터 우르솔릭산을 고효율로 추출하는 방법 및 그 방법에 의해 추출된 우르솔릭산을 유효성분으로 함유하는 식품조성물 |
KR101637322B1 (ko) * | 2015-09-21 | 2016-07-08 | 주식회사한국야쿠르트 | 사과박 주정 추출물을 유효성분으로 함유하는 조성물 |
KR20180092812A (ko) | 2017-12-26 | 2018-08-20 | 전남대학교산학협력단 | 옻나무 목질부 추출물을 포함하는 어류의 항균, 항기생충, 항바이러스 및 항산화 조성물 |
KR20190058394A (ko) | 2019-03-29 | 2019-05-29 | 전남대학교산학협력단 | 옻나무 목질부 추출물을 포함하는 어류의 항균, 항기생충, 항바이러스 및 항산화 조성물 |
Families Citing this family (2)
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CN107427592A (zh) | 2015-01-05 | 2017-12-01 | 株式会社露太利温 | 使用luterion抑制癌细胞中端粒酶的方法 |
KR102119812B1 (ko) * | 2018-06-05 | 2020-06-05 | 경희대학교 산학협력단 | 칠피 추출물을 포함하는 자궁근종 예방 또는 치료용 약학 조성물 |
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KR20050047339A (ko) * | 2003-11-17 | 2005-05-20 | (주)생명의나무 | 옻나무 추출물을 함유하는 진통억제용 조성물 |
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KR20050047339A (ko) * | 2003-11-17 | 2005-05-20 | (주)생명의나무 | 옻나무 추출물을 함유하는 진통억제용 조성물 |
Non-Patent Citations (1)
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한국식품과학회지 31(1), pp.238-245, (1999.)* |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012020892A1 (ko) | 2010-08-11 | 2012-02-16 | (주)에이지아이 | 활성형 플라보노이드 화합물의 함량이 증가된 옻나무 추출물 및 그의 제조 방법 |
KR20150130639A (ko) * | 2014-05-13 | 2015-11-24 | 주식회사한국야쿠르트 | 사과박(apple pomace)으로부터 우르솔릭산을 고효율로 추출하는 방법 및 그 방법에 의해 추출된 우르솔릭산을 유효성분으로 함유하는 식품조성물 |
KR101645963B1 (ko) * | 2014-05-13 | 2016-08-08 | 주식회사한국야쿠르트 | 사과박(apple pomace)으로부터 우르솔릭산을 고효율로 추출하는 방법 및 그 방법에 의해 추출된 우르솔릭산을 유효성분으로 함유하는 식품조성물 |
KR101637322B1 (ko) * | 2015-09-21 | 2016-07-08 | 주식회사한국야쿠르트 | 사과박 주정 추출물을 유효성분으로 함유하는 조성물 |
KR20180092812A (ko) | 2017-12-26 | 2018-08-20 | 전남대학교산학협력단 | 옻나무 목질부 추출물을 포함하는 어류의 항균, 항기생충, 항바이러스 및 항산화 조성물 |
KR20190058394A (ko) | 2019-03-29 | 2019-05-29 | 전남대학교산학협력단 | 옻나무 목질부 추출물을 포함하는 어류의 항균, 항기생충, 항바이러스 및 항산화 조성물 |
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