KR100909122B1 - 신규한 벤조-융합된 헤테로환 - Google Patents
신규한 벤조-융합된 헤테로환 Download PDFInfo
- Publication number
- KR100909122B1 KR100909122B1 KR1020047001815A KR20047001815A KR100909122B1 KR 100909122 B1 KR100909122 B1 KR 100909122B1 KR 1020047001815 A KR1020047001815 A KR 1020047001815A KR 20047001815 A KR20047001815 A KR 20047001815A KR 100909122 B1 KR100909122 B1 KR 100909122B1
- Authority
- KR
- South Korea
- Prior art keywords
- phenyl
- benzo
- yloxy
- acetic acid
- pyrimidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 0 *CC(*)C1(*)c2c(*)c(*)c(*)c(*)c2**1 Chemical compound *CC(*)C1(*)c2c(*)c(*)c(*)c(*)c2**1 0.000 description 10
- AMLOYMNQUCVOBB-SQHAQQRYSA-N CCc1nc(O[C@@H]([C@](c2ccccc2)(c2ccccc2N2CCO)NCC2=O)C(O)=O)nc(CC)c1 Chemical compound CCc1nc(O[C@@H]([C@](c2ccccc2)(c2ccccc2N2CCO)NCC2=O)C(O)=O)nc(CC)c1 AMLOYMNQUCVOBB-SQHAQQRYSA-N 0.000 description 1
- BIIBDMFLIDJRGA-RDGATRHJSA-N COc1nc(O[C@@H]([C@](c2ccccc2)(c2ccccc2N2CCO)NCC2=O)C(O)=O)nc(OC)c1 Chemical compound COc1nc(O[C@@H]([C@](c2ccccc2)(c2ccccc2N2CCO)NCC2=O)C(O)=O)nc(OC)c1 BIIBDMFLIDJRGA-RDGATRHJSA-N 0.000 description 1
- KDWODULSZOKENH-OFNKIYASSA-N Cc(cn1)cnc1O[C@@H]([C@](c1ccccc1)(c1cc(Cl)ccc1N1C)NCC1=O)C(O)=O Chemical compound Cc(cn1)cnc1O[C@@H]([C@](c1ccccc1)(c1cc(Cl)ccc1N1C)NCC1=O)C(O)=O KDWODULSZOKENH-OFNKIYASSA-N 0.000 description 1
- TUTZGEFUGWQBKP-RDGATRHJSA-N Cc1nc(O[C@@H]([C@](c2ccccc2)(c2ccccc2N2CCO)NCC2=O)C(O)=O)nc(C)c1 Chemical compound Cc1nc(O[C@@H]([C@](c2ccccc2)(c2ccccc2N2CCO)NCC2=O)C(O)=O)nc(C)c1 TUTZGEFUGWQBKP-RDGATRHJSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
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- C07D243/24—Oxygen atoms
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- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Reproductive Health (AREA)
- Oncology (AREA)
- Child & Adolescent Psychology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP0109235 | 2001-08-09 | ||
| EPPCT/EP01/09235 | 2001-08-09 | ||
| PCT/EP2002/008523 WO2003013545A1 (en) | 2001-08-09 | 2002-07-31 | Novel benzo-fused heterocycles as endothelin antagonisits |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20040030937A KR20040030937A (ko) | 2004-04-09 |
| KR100909122B1 true KR100909122B1 (ko) | 2009-07-23 |
Family
ID=8164539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020047001815A Expired - Fee Related KR100909122B1 (ko) | 2001-08-09 | 2002-07-31 | 신규한 벤조-융합된 헤테로환 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7238685B2 (https=) |
| JP (1) | JP4364637B2 (https=) |
| KR (1) | KR100909122B1 (https=) |
| CN (1) | CN100418955C (https=) |
| AR (1) | AR036386A1 (https=) |
| AU (1) | AU2002328999B8 (https=) |
| BR (1) | BR0211729A (https=) |
| CA (1) | CA2454417A1 (https=) |
| HU (1) | HUP0401107A3 (https=) |
| IL (1) | IL159963A0 (https=) |
| MX (1) | MXPA04001252A (https=) |
| NO (1) | NO20040563L (https=) |
| NZ (1) | NZ530741A (https=) |
| WO (1) | WO2003013545A1 (https=) |
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Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2540987T3 (es) | 2004-05-14 | 2015-07-15 | Millennium Pharmaceuticals, Inc. | Métodos para preparar inhibidores de la aurora cinasa |
| US7718648B2 (en) | 2006-08-09 | 2010-05-18 | Millennium Pharmaceuticals, Inc. | Pyridobenzazepine compounds and methods for inhibiting mitotic progression |
| CL2007003244A1 (es) | 2006-11-16 | 2008-04-04 | Millennium Pharm Inc | Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer. |
| WO2008108445A1 (ja) | 2007-03-07 | 2008-09-12 | Takeda Pharmaceutical Company Limited | ベンゾオキサゼピン誘導体およびその用途 |
| US9096546B2 (en) * | 2007-05-10 | 2015-08-04 | Albany Molecular Research, Inc. | Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
| EP2170350B1 (en) * | 2007-06-21 | 2013-09-11 | Cara Therapeutics, Inc. | Substituted imidazoheterocycles |
| US8119629B2 (en) | 2007-10-03 | 2012-02-21 | Bristol-Meyers Squibb Company | Carboxamide GABAA α2 modulators |
| WO2010068520A2 (en) * | 2008-12-11 | 2010-06-17 | Cara Therapeutics, Inc. | Substituted imidazoheterocycle derivatives |
| RU2535032C2 (ru) | 2008-12-22 | 2014-12-10 | Милленниум Фармасьютикалз, Инк. | Сочетание ингибиторов аврора киназы и анти-cd 20 антител |
| JO3635B1 (ar) | 2009-05-18 | 2020-08-27 | Millennium Pharm Inc | مركبات صيدلانية صلبة وطرق لانتاجها |
| CA2788774A1 (en) | 2010-02-19 | 2011-08-25 | Millennium Pharmaceuticals, Inc. | Crystalline forms of sodium 4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5h-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoate |
| CN101805283B (zh) * | 2010-03-23 | 2013-01-02 | 渤海大学 | 含薁类结构的1,4-二氢吡啶类化合物及其制备方法 |
| US20130303519A1 (en) | 2012-03-20 | 2013-11-14 | Millennium Pharmaceuticals, Inc. | Methods of treating cancer using aurora kinase inhibitors |
| WO2014153509A1 (en) | 2013-03-22 | 2014-09-25 | Millennium Pharmaceuticals, Inc. | Combination of catalytic mtorc 1/2 inhibitors and selective inhibitors of aurora a kinase |
| JP2018524292A (ja) | 2015-07-21 | 2018-08-30 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | オーロラキナーゼインヒビターと化学療法剤の投与 |
| CN112939855B (zh) * | 2021-02-08 | 2024-03-26 | 马鞍山市泰博化工科技有限公司 | 一种制备含有薁环结构的1,4-二氢吡啶衍生物的方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5420123A (en) * | 1992-12-21 | 1995-05-30 | Bristol-Myers Squibb Company | Dibenzodiazepine endothelin antagonists |
| US5614498A (en) * | 1990-06-07 | 1997-03-25 | Banyu Pharmaceutical Co., Ltd. | Endothelin antagonistic substance |
| US5710150A (en) * | 1993-08-26 | 1998-01-20 | Yamanouchi Pharmaceutical Co., Ltd. | Benzazepine derivative, pharmaceutical composition thereof, and intermediate thereof |
| JP2000143636A (ja) * | 1998-09-02 | 2000-05-26 | Sumitomo Pharmaceut Co Ltd | アミノ誘導体 |
-
2002
- 2002-07-31 JP JP2003518554A patent/JP4364637B2/ja not_active Expired - Fee Related
- 2002-07-31 HU HU0401107A patent/HUP0401107A3/hu unknown
- 2002-07-31 CN CNB028155394A patent/CN100418955C/zh not_active Expired - Fee Related
- 2002-07-31 IL IL15996302A patent/IL159963A0/xx unknown
- 2002-07-31 AU AU2002328999A patent/AU2002328999B8/en not_active Ceased
- 2002-07-31 MX MXPA04001252A patent/MXPA04001252A/es active IP Right Grant
- 2002-07-31 CA CA002454417A patent/CA2454417A1/en not_active Abandoned
- 2002-07-31 BR BR0211729-0A patent/BR0211729A/pt not_active IP Right Cessation
- 2002-07-31 WO PCT/EP2002/008523 patent/WO2003013545A1/en not_active Ceased
- 2002-07-31 NZ NZ530741A patent/NZ530741A/en not_active IP Right Cessation
- 2002-07-31 KR KR1020047001815A patent/KR100909122B1/ko not_active Expired - Fee Related
- 2002-07-31 US US10/486,602 patent/US7238685B2/en not_active Expired - Fee Related
- 2002-08-06 AR ARP020102979A patent/AR036386A1/es unknown
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2004
- 2004-01-30 ZA ZA200400803A patent/ZA200400803B/xx unknown
- 2004-02-06 NO NO20040563A patent/NO20040563L/no not_active Application Discontinuation
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5614498A (en) * | 1990-06-07 | 1997-03-25 | Banyu Pharmaceutical Co., Ltd. | Endothelin antagonistic substance |
| US5420123A (en) * | 1992-12-21 | 1995-05-30 | Bristol-Myers Squibb Company | Dibenzodiazepine endothelin antagonists |
| US5710150A (en) * | 1993-08-26 | 1998-01-20 | Yamanouchi Pharmaceutical Co., Ltd. | Benzazepine derivative, pharmaceutical composition thereof, and intermediate thereof |
| JP2000143636A (ja) * | 1998-09-02 | 2000-05-26 | Sumitomo Pharmaceut Co Ltd | アミノ誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| NZ530741A (en) | 2006-08-31 |
| JP4364637B2 (ja) | 2009-11-18 |
| US7238685B2 (en) | 2007-07-03 |
| KR20040030937A (ko) | 2004-04-09 |
| HUP0401107A3 (en) | 2004-10-28 |
| CA2454417A1 (en) | 2003-02-20 |
| CN1538848A (zh) | 2004-10-20 |
| ZA200400803B (en) | 2005-05-03 |
| AU2002328999B8 (en) | 2008-06-05 |
| WO2003013545A1 (en) | 2003-02-20 |
| BR0211729A (pt) | 2004-08-24 |
| NO20040563L (no) | 2004-03-08 |
| AR036386A1 (es) | 2004-09-08 |
| HUP0401107A2 (hu) | 2004-08-30 |
| AU2002328999B2 (en) | 2008-05-15 |
| MXPA04001252A (es) | 2004-05-27 |
| CN100418955C (zh) | 2008-09-17 |
| JP2005502644A (ja) | 2005-01-27 |
| IL159963A0 (en) | 2004-06-20 |
| US20050124605A1 (en) | 2005-06-09 |
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