KR100886161B1 - 항암제로서의 배리올린 유도체 - Google Patents

항암제로서의 배리올린 유도체 Download PDF

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Publication number
KR100886161B1
KR100886161B1 KR1020027018072A KR20027018072A KR100886161B1 KR 100886161 B1 KR100886161 B1 KR 100886161B1 KR 1020027018072 A KR1020027018072 A KR 1020027018072A KR 20027018072 A KR20027018072 A KR 20027018072A KR 100886161 B1 KR100886161 B1 KR 100886161B1
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KR
South Korea
Prior art keywords
group
formula
compound
alkyl
groups
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Expired - Fee Related
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KR1020027018072A
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English (en)
Korean (ko)
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KR20030017581A (ko
Inventor
모리스조나단찰스
앤더슨리건제임스
레무이냔모데스또
만자나레스이그나씨오
Original Assignee
파르마 마르, 에스.에이.
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Priority claimed from GB0017055A external-priority patent/GB0017055D0/en
Priority claimed from GB0030689A external-priority patent/GB0030689D0/en
Application filed by 파르마 마르, 에스.에이. filed Critical 파르마 마르, 에스.에이.
Publication of KR20030017581A publication Critical patent/KR20030017581A/ko
Application granted granted Critical
Publication of KR100886161B1 publication Critical patent/KR100886161B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
KR1020027018072A 2000-07-11 2001-07-11 항암제로서의 배리올린 유도체 Expired - Fee Related KR100886161B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0017055A GB0017055D0 (en) 2000-07-11 2000-07-11 Synthesis
GB0017055.5 2000-07-11
GB0030689.4 2000-12-15
GB0030689A GB0030689D0 (en) 2000-12-15 2000-12-15 Synthesis
PCT/GB2001/003111 WO2002004447A1 (en) 2000-07-11 2001-07-11 Variolin derivatives as anti-cancer agents

Publications (2)

Publication Number Publication Date
KR20030017581A KR20030017581A (ko) 2003-03-03
KR100886161B1 true KR100886161B1 (ko) 2009-02-27

Family

ID=26244637

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027018072A Expired - Fee Related KR100886161B1 (ko) 2000-07-11 2001-07-11 항암제로서의 배리올린 유도체

Country Status (20)

Country Link
US (1) US7320981B2 (https=)
EP (1) EP1299388B1 (https=)
JP (1) JP2004502773A (https=)
KR (1) KR100886161B1 (https=)
CN (1) CN1324028C (https=)
AT (1) ATE431349T1 (https=)
AU (3) AU2001270783B2 (https=)
BR (1) BR0112413A (https=)
CA (1) CA2414200C (https=)
CY (1) CY1109283T1 (https=)
DE (1) DE60138707D1 (https=)
DK (1) DK1299388T3 (https=)
ES (1) ES2327210T3 (https=)
IL (2) IL153682A0 (https=)
MX (1) MXPA03000341A (https=)
NZ (1) NZ523491A (https=)
PT (1) PT1299388E (https=)
RU (1) RU2299884C2 (https=)
SI (1) SI1299388T1 (https=)
WO (1) WO2002004447A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0019117D0 (en) * 2000-08-03 2000-09-27 Univ Barcelona Derivatives of variolin B
GB0116966D0 (en) * 2001-07-11 2001-09-05 Pharma Mar Sa Anittumoral compounds
MXPA05012377A (es) 2003-05-15 2006-05-25 Arqule Inc Derivados de imidazotiazoles e imidazoxazol como inhibidores de p38.
WO2006010082A1 (en) 2004-07-08 2006-01-26 Arqule, Inc. 1,4-disubstituted naphtalenes as inhibitors of p38 map kinase
JP2008517064A (ja) 2004-10-19 2008-05-22 アークル インコーポレイテッド Ｐ３８ｍａｐキナーゼのイミダゾオキサゾールおよびイミダゾチアゾール阻害剤の合成
EP1666467A1 (en) * 2004-11-08 2006-06-07 Evotec AG 11Beta-HSD1 Inhibitors
WO2006075591A1 (ja) * 2005-01-12 2006-07-20 Kuraray Co., Ltd. 樹脂組成物及びそれからなるフィルム
DE602006014540D1 (en) * 2005-05-16 2010-07-08 Irm Llc Pyrrolopyridinderivate als proteinkinaseinhibitoren
HRP20231233T1 (hr) 2017-04-27 2024-01-19 Pharma Mar, S.A. Antitumorski spojevi

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI944602A0 (fi) * 1992-04-03 1994-10-03 Upjohn Co Farmaseuttisesti aktiiviset bisyklis-heterosykliset amiinit
GB0019117D0 (en) * 2000-08-03 2000-09-27 Univ Barcelona Derivatives of variolin B
GB0116966D0 (en) 2001-07-11 2001-09-05 Pharma Mar Sa Anittumoral compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Tetrahedron, 50(13), 3987-3992(1994)*

Also Published As

Publication number Publication date
WO2002004447A1 (en) 2002-01-17
DK1299388T3 (da) 2009-08-31
NZ523491A (en) 2004-06-25
CY1109283T1 (el) 2014-07-02
CN1630658A (zh) 2005-06-22
CA2414200A1 (en) 2002-01-17
EP1299388B1 (en) 2009-05-13
MXPA03000341A (es) 2004-04-05
BR0112413A (pt) 2003-05-27
PT1299388E (pt) 2009-08-13
CN1324028C (zh) 2007-07-04
US7320981B2 (en) 2008-01-22
DE60138707D1 (de) 2009-06-25
CA2414200C (en) 2010-05-04
AU7078301A (en) 2002-01-21
ES2327210T3 (es) 2009-10-27
IL153682A (en) 2010-05-31
JP2004502773A (ja) 2004-01-29
RU2299884C2 (ru) 2007-05-27
EP1299388A1 (en) 2003-04-09
KR20030017581A (ko) 2003-03-03
US20050014778A1 (en) 2005-01-20
ATE431349T1 (de) 2009-05-15
AU2006213946B2 (en) 2008-01-10
AU2006213946A1 (en) 2006-10-05
SI1299388T1 (sl) 2009-12-31
IL153682A0 (en) 2003-07-06
AU2001270783B2 (en) 2006-06-15

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