KR100796904B1 - Compositions for promoting hair growth containing complexes of stabilized Vitamin C or Vitamin C derivatives - Google Patents

Abstract

The present invention relates to a hair regrowth composition using the antioxidant action of vitamin C or vitamin C derivatives, the hair regrowth composition according to the present invention contains a complex of a water-soluble beta glucan and a vitamin C or vitamin C derivative stabilized from trehalose, vitamin C Alternatively, the complex of vitamin C derivatives has excellent antioxidant effect while maintaining stability in aqueous solution, and these compositions are produced by activation of hair follicles by immunity enhancing action of water-soluble beta glucan and vigorous division of hair follicle cells by disaccharide trehalose. The sebum is prevented from accumulating as lipid peroxide in the scalp to prevent new hair growth by the antioxidant action of the complex of vitamin C or vitamin C derivatives, has the advantage of preventing hair loss and hair growth, and has no side effects on the scalp.

Vitamin C, Vitamin C Derivatives, Hair Regrowth, Beta Glucan, Trehalose, Stabilized Vitamin C Complex

Description

Compositions for promoting hair growth containing complexes of stabilized Vitamin C or Vitamin C derivatives}

The present invention relates to a hair restorer composition containing a complex of vitamin C or vitamin C derivatives stabilized for growth of hair in a resting state, and atrophy in a long-term resting state due to hair loss using immunity enhancing action of beta glucan. By activating the hair follicles and supplying sugars to the activated hair follicles, the hair follicle cells are actively divided, and the accumulation of sebum produced as lipid peroxide in the scalp is stabilized in a complex of vitamin C or vitamin C derivatives. According to a series of processes to prevent hair follicles reformation of the hair follicles (restoration) by restraining the new hair growth method and hair loss prevention, as well as to provide a hair regrowth composition having a certain hair growth effect and no side effects to the human body.

Hair loss from the scalp is caused by a number of factors, including internal factors such as genetic constitution or the action of testosterone, or external factors such as mental stress in everyday life and the accumulation of lipid peroxide in the scalp. It is known that these factors are intricately involved and cause alopecia. In recent years, hair loss in young people, including obesity hair loss of women as well as male hair loss has been gradually spread, and many kinds of hair growth or hair growth agents are marketed to improve the hair loss phenomenon.

The main ingredients used in commercial hair growth or hair growth agents include vasodilators such as capronium chloride, minoxidil, and extracts of various plants to circulate enough blood in the scalp, or male hormones that drop hair by attaching them to the nipples. There are female hormones, such as estrogen, estradiol, progesterone, or male hormone activation inhibitors, such as pentadecanoic acid and finasteride, for inhibiting its action. For example, the drug approved by the US Food and Drug Administration (FDA) as a hair loss treatment is two types of drugs, minoxidil, by vasodilating action, and oral propecia, by inhibiting the activation of the male hormone based on finasteride. Due to its action, it is widely used as an agent having excellent hair loss prevention effect. However, most of the hair growth and hair growth agents described above have some effects on the prevention of hair loss, but the effects related to hair growth were not necessarily satisfactory. In other words, these preparations are effective only in the area where the hair roots are activated, so the hair loss prevention effect is significant, but the hair growth, or hair growth effect, of hair in a long-term rest period is insignificant. It is known to be ineffective.

In the case of alopecia areata, in which the hair suddenly disappears in one or several areas of the scalp, it is known that the hair follicle is attacked by lymphocytes by the modulation of the immune system and the developmental state is suddenly stopped. In this regard, some scientists view baldness as one of the "autoimmune diseases" such as alopecia areata and suggest that male hormones (dihydrotestosterone, DHT) cause an immune response that destroys the hair roots. In other words, in people with alopecia, white blood cells are recognized as external proteins to remove hair follicles, and autologous antibodies are generated to attack hair follicles. When autoantibodies are produced, the thymus contracts, which weakens the function of the immune system. As a result, hair follicles shrink, leaving hair thinner and less dense. According to Japanese Laid-Open Patent Publication No. 2002-080494, it has been reported that the immune-enhancing action of the peptide extracted from soybean has an excellent effect on the prevention of hair loss caused by side effects caused by the use of anticancer drugs. The role of sebum is also emphasized as one of the main causes of hair loss. Sebum secreted into the scalp from the hair follicles during the growth phase is hardened by the formation of lipid peroxide in the scalp layer by active oxygen or UV irradiation. Necrosis will be brought to promote hair loss.

Hair hair is a growth cycle → degenerative stage → rest stage → hair cycle, which is called a growth stage.Alopecia refers to a state in which the resting stage is long and the growing stage is short, and that the resting stage is much longer than normal (2-4 months). It was a common perception that the hair follicles would shrink or shrink and continue to be nearly impossible for hair growth to date.

On the other hand, a hair regrowth composition containing beta glucan, which is an immunomodulator, has been known in International Patent Publication Nos. 00/6188 and 595,209. International Publication No. 00/6188 discloses a hair regrowth composition containing an immunomodulatory substance such as muramidase, interferon, and beta glucan, but the immunomodulatory substance in the hair repellent composition functions by any mechanism It is not recognized whether hair growth occurs, and there is also a lack of understanding of the relationship with other groups of compounds contained in the composition, so that no synergistic effect can be found by the addition of each composition, and more specifically, As a result of 3 months of treatment, effective hair growth effects could not be confirmed, and after 9 months of long-term treatment, the effect of the hair growth is insufficient. EP-A-595,209 discloses a cosmetic comprising beta glucan, which acts as an epidermal conditioner, but does not specifically mention the hair growth effect.

On the other hand, in general, for the purpose of activating the immune system to treat intractable diseases such as cancer is called immunotherapy and the following are used. Biological Response Modifiers (BRMs), which increase immunity as a natural product rather than synthesized chemicals, exhibit various physiological effects by stimulating the immune system to change the biological response of the host, especially chemical anticancer drugs. It is used in combination with the treatment of various cancer patients. The polysaccharides extracted from mushrooms are known as krestin, lentinan, beta glucan, and active hexose correlated compounds (AHCC). In particular, AHCC is orally administered to various types of cancer patients, and there is no side effect as well as cancer treatment by immunity enhancement, and it has the characteristics to reduce the side effects such as hair loss, vomiting, and pain caused by anticancer drugs. It is used as an adjuvant therapy.

On the other hand, beta glucan is a polysaccharide extracted from yeast fungus or yeast, is reported as a substance that enhances the immune function of animals and attracts attention as a natural immune modulator without resistance, the activity of beta glucan is molecular weight, DB It is known to be affected by degree of branch, structure, degree of solubility, and bonding between molecules. Beta glucans have side chains at carbon 4 in the basic skeleton (beta- (1,3) glucans) in which glucose units are linked by beta-glucoside bonds at positions 1,3 (beta- (1,3 / 1, 4) glucan) or having a side chain on carbon 6 (beta- (1,3 / 1,6) glucan), which is substantially beta- (1,6) in US Patent No. 6,497,865. Although a hair composition comprising a water-soluble beta- (1,3) glucan and antioxidants, which does not contain glucan, is disclosed, the compositions containing only beta- (1,3) glucan are actually hair growth or wool. Almost no effect.

The inventors of the present invention recently used beta glucan immunity enhancing action in Korean Patent Application Nos. 2003-19436 and 2005-13854 to activate hair follicles contracted in a long-term rest state due to hair loss, and activated hair follicles. By supplying sugars to the nutrient source, the hair follicle cells are actively divided and the hair follicles are reformed according to a series of processes that prevent the sebum produced by the antioxidant from accumulating as lipid peroxide in the scalp. A method for growing hair by resting period breakdown is proposed, beta glucan is selected as a substance for promoting the activity of the immune system in BRM, and a hair regrowth composition containing sugars and antioxidants together with beta glucan has been disclosed. The composition has the advantage of preventing hair loss as well as having a definite hair growth effect and no side effects to the human body.

The hair repellent composition according to the Korean Patent Application Nos. 2003-19436 and 2005-13854 solves the drawbacks of the conventional hair repellent composition and also demonstrates the new hair growth method that has not been known to date. In addition, the hair follicles are reduced in size by activating the immunity-enhancing 'autoimmune neutralization effect' and thus smoothing hair follicles of smooth bald heads. It provides a nutrient as a source of nutrients at the same time, which stimulates hair follicle cell division, and at this time, breaks down the hair follicles by reforming hair follicles by using an antioxidant to prevent sebum from accumulating from the scalp into lipid peroxide. By preventing hair loss as well as showing a certain hair growth effect.

However, the antioxidant used in the composition according to the present invention is not particularly limited, but green tea extract is used, and the use of plant extracts is limited due to the amount thereof, and thus the anti-oxidant composition is not obtained. When used on the scalp, there is a weak point that the hair growth effect after a certain level of initial hair growth does not meet expectations.

On the other hand, vitamin C enhances the body's immune function, promotes the production of collagen, which is a component of skin, cartilage, capillaries, and muscles, and destroys chemicals caused by UV rays penetrating the skin to prevent skin damage. Role. It also prevents wrinkles and keeps your skin healthy by the antioxidant action that eliminates free radicals that are the main causes of skin aging. Vitamin C, also known as an anti-bleeding factor, helps to heal blood tissue from capillaries and helps to heal wounded skin tissues, and the formation of histamine, known to cause an allergic reaction, and the formation of melanin that discolors the skin during the aging process. It serves to prevent. However, vitamin C is unstable and has a problem in that it is easily decomposed by reacting sensitively to air, especially oxygen and external environment such as heat and light. A large amount of vitamin C is dissolved in the aqueous solution, but a sufficient amount of vitamin C cannot be stabilized due to rapid oxidation, so only a small amount of vitamin C can be used as an active ingredient in medicine, food, and cosmetics. It is.

Therefore, an object of the present invention is to increase the absorption effect of the immunoactive substance on the scalp based on the hair growth method established by the present inventors to maintain the activity of the hair follicles at the same time the sebum produced in the scalp is lipid peroxide It is to provide a hair regrowth composition which improves the hair regrowth effect by continuing to remove the accumulation by using the antioxidant action of vitamin C or vitamin C derivatives to maintain the hair growth effect even after a certain level of hair growth, and another object is By stabilizing vitamin C or vitamin C derivatives from water-soluble beta glucan and trehalose, there is provided a hair regrowth composition containing a complex of stabilized vitamin C or vitamin C derivatives having antioxidant activity for a long time in an unoxidized state.

The present invention relates to a hair regrowth composition containing a stabilized complex of vitamin C or vitamin C derivatives, wherein the hair regrowth composition according to the present invention is extracted from yeast and stabilized from low molecular weight beta glucan and trehalose having a molecular weight of 30,000 to 100,000 Da. 0.1 to 20% by weight of the complex of prepared vitamin C or vitamin C derivatives; Mushroom mushroom mycelium extract 0.1 to 10% by weight; And the remainder is one or more selected from purified water, ethanol, isopropanol;

The vitamin C or vitamin C derivative contained in the hair regrowth composition according to the present invention is a complex of beta glucan and vitamin C or vitamin C derivative stabilized from trehalose. Vitamin C or vitamin C derivatives are substances that have various effects such as anti-aging, whitening, and collagen production, which improves elasticity and wrinkles, wound healing, UV protection, and antioxidant, which prevent skin melanin production. . The vitamin C or vitamin C derivative is present as a white powder, but when dissolved in a solvent such as water, it is oxidized and hydrolyzed by factors such as pH, moisture, air contact, and temperature to completely break the ring structure. It turns into a yellowish, brownish, low-molecular substance with an odor.

The hair regrowth composition according to the present invention is extracted from yeast from 0.1 to 20% by weight of vitamin C or vitamin C derivative having excellent antioxidant effect as described above, and 0.01 to 10% by weight of beta glucan low molecular weight of 30,000 to 100,000 Da and trehalose. Simultaneously dissolved in 0.1 to 10% by weight and purified water, it is characterized by containing a complex of stabilized vitamin C or vitamin C derivatives stabilized from beta glucan and trehalose and having an antioxidant action for a long time.

The complex of beta glucan and stabilized vitamin C or vitamin C derivatives from trehalose is preferably from 0.1 to 20% by weight, more preferably from 0.1 to 10% by weight, and the complex of stabilized vitamin C or vitamin C derivatives. By preventing the sebum produced by the active division of hair follicle cells to accumulate as lipid peroxide in the scalp, hair loss prevention and hair growth effect, there is no side effect on the scalp.

Vitamin C derivatives include sodium ascorbyl phosphate, magnesium ascorbyl phosphate, ascorbyl palmitate, ascorbyl dipalmitate or ascorbyl dipalmitate. At least one selected from the group consisting of ascorbyl glucoside is used.

The mechanism for the hair formation method employed in the hair regrowth composition according to the present invention is a BRM (Biological Response Modifier) which increases immunity to hair follicles in a long period of rest due to hair loss in the hair cycle. It activates hair follicles by 'autoimmune neutralizing effect', and stimulates hair follicle cell division by simultaneously supplying sugars as nutrients to activated hair follicles, and stabilized vitamins that accumulate sebum produced as lipid peroxide in scalp Following a series of processes prevented by a complex of C or vitamin C derivatives, the hair follicles re-form, ie, the hair cycle transitions from prolonged rest periods to growth phases, where new hair grows.

As mentioned above, the activity of beta glucan selected as BRM in the present invention is affected by molecular weight, degree of branch (DB), structure, degree of solubility, binding between molecules, and the hair regrowth composition according to the present invention. The hair growth effect by is most affected by the molecular weight.

In the case of beta glucan extracted from oats, hair follicles are not activated due to improper DB (degree of branch) and structure, and beta glucan extracted from yeast acts to activate hair follicles. However, since the molecular weight is 1 Mda or more, it does not dissolve in water, and thus the absorption ability to the scalp is poor, and thus, hair follicles are not sufficiently activated. Also, the water solubility or poor solubility in alcohol causes precipitation of the composition, thereby degrading the commerciality. On the other hand, beta glucan extracted from basidiomycete mycelium is water soluble and has good absorption ability to the scalp and good hair follicle activating effect, but the amount of beta glucan contained in the extract of basidiomycete mycelium is extremely small, resulting in continuous hair follicle activating effect. There is a limit, and the price is also very expensive, there is a disadvantage of low economical, the hair regrowth composition according to the present invention can be extracted in large quantities, by adding a low molecular weight beta glucan extracted from a cheap yeast to the scalp Low molecular weighted beta glucan was employed in order to increase the absorption ability of the and to increase the solubility in the solvent.

The low molecular weight of high molecular weight beta glucan can be achieved by physical methods such as ultrasonic treatment, chemical methods such as acid treatment, and enzymatic methods using substrate specific enzymatic reaction, which are known in the art. However, the method for reducing the molecular weight by ultrasonic treatment has a disadvantage in that the efficiency decreases according to the treatment time, and there is a disadvantage in that there is a structural variation. In the present invention, the reduced molecular weight obtained by an acid treatment method or an enzyme treatment method is reduced in beta glucan. Was used.

Beta glucan extracted from yeast according to the invention and low molecular weight with a molecular weight of 30,000 to 100,000 Da is particularly preferably a low molecular weight beta- (1,3 / 1,6) glucan or carboxy with a molecular weight of 30,000 to 100,000 Da. Methyl beta- (1,3 / 1,6) glucan, or a mixture thereof, and still more preferably beta- (1,3 / 1,6) glucan having a molecular weight of about 30,000 to 100,000 Da. In particular, it is preferable to maintain the degree of branching of beta- (1,3 / 1,6) glucan in the course of molecular weight grinding. Beta glucan having a molecular weight of 30,000 Da or less has a problem of poor immune activity, and in case of 100,000 Da or more, epidermal absorption and solubility are poor. Proper molecular weight reduction by acid treatment or enzymatic reaction makes it difficult to obtain beta glucan having a molecular weight of 30,000 to 100,000 Da, but the reduced molecular weight beta glucan obtained after the molecular weight reduction reaction can be replaced by an UF membrane or a cut-off membrane. It is even more preferable to remove the high molecular weight beta glucan or to remove the oligomer beta glucan using and the like.

The low molecular weight beta glucan, which acts to activate the hair follicle cells in the resting phase, is not toxic to the human body, and thus the amount of the beta glucan is not limited and can be selected in a wide range. However, the content of the beta glucan is 0.01% by weight. When the amount is less than%, the hair follicle cells cannot be activated, and when the amount is more than 10% by weight, there is no significant difference in effect, but there is an economic disadvantage, so the content of beta glucan is used within the range of 0.01 to 10% by weight based on the total amount. It is preferable that it is more preferable to carry out still more preferably in the range of 0.1 to 2 weight%.

The disaccharide trehalose according to the present invention is preferably 0.1 to 10% by weight, more preferably 0.1 to 5% by weight, and the trehalose is supplied as a nutrient to hair follicles activated by low molecular weighted beta glucan to divide hair follicle cells. To be fulfilled vigorously.

Phellinus linteus mycelium extract according to the present invention is not particularly limited in relation to the preparation of the extract, but in order to increase the extraction efficiency of the water-soluble polysaccharide contained in the mycelium, the mycelium of the situation mushroom from cellulase or protease enzyme It is a dry powder obtained by extracting it through two steps of enzymatic reaction and hot water extraction using one or a mixture thereof, and the extract is composed mainly of water-soluble polysaccharides, and particularly contains water-soluble beta glucan. The activity of hair follicles, but the amount of beta glucan in the extract is very small, there is a disadvantage that does not have a continuous function of hair follicles active when used alone, and thus the low molecular weight beta glucan extracted from yeast extract the situation mushroom The situation mushroom extraction by using with Due to the synergy of the various kinds of polysaccharides, including the water-soluble beta-glucan, which is contained in a continuous and enable enhanced action of the hair follicle.

Therefore, the situation mushroom mycelium extract is an essential component in the hair regrowth composition according to the present invention, the situation mushroom mycelium extract contains 1 to 10 weight ratio for the low molecular weight beta glucan with a molecular weight of 30,000 to 100,000 Da, In the whole hair repellent composition, 0.1 to 10 weight% is preferable, and 0.1-5 weight% of the situation mushroom mycelium extract is more preferable.

The remaining components of the hair regrowth composition according to the present invention include a solvent for diluting and dissolving a complex of a low molecular weighted beta glucan and a stabilized vitamin C or vitamin C derivative from trehalose and an extract of mushroom mushroom mycelium. The solvent uses one or more selected from purified water, ethanol, and isopropanol, and the amount of the solvent is a complex of a low molecular weighted beta glucan and trehalose, a complex of vitamin C or a vitamin C derivative stabilized from trehalose, and the amount of the situation mushroom mycelium extract. It is configured as the remaining amount except.

Preferred hair regrowth compositions according to the present invention comprise 0.1 to 10% by weight of a complex of vitamin C or vitamin C derivatives stabilized from beta glucan and trehalose; Mushroom mushroom mycelium extract 0.1 to 5% by weight; And the remainder is characterized in that at least one selected from purified water, ethanol or isopropanol.

In addition to these main components, the hair regrowth composition of this invention can contain various well-known materials normally mix | blended with the cosmetics expecting hair growth and a hair growth effect as needed. Examples are antimicrobials, coolants, moisturizers or mixtures thereof. Examples of the antimicrobial agents include hinoki chiol, chitosan, polyrigin, sodium benzoate, parabens and the like. As a coolant, menthol etc. are mentioned as an example. Examples of the moisturizer include polyhydric alcohols such as glycerin, propylene glycol, 1, 3-butylene glycol, sorbitol, mannitol, and polyethylene glycol, and can be used alone or as a mixture. As the additive, for example, fats and oils, surfactants, alcohols, fatty acids, pigments, flavoring agents, ultraviolet absorbers, chelating agents, pH adjusters, buffers and the like can be appropriately selected.

The hair regrowth composition of the present invention contains the aforementioned main ingredients and can be used in the form of various hair regrowth, hair loss prevention or hair external preparations for hair or scalp such as hair tonic, hair lotion, hair cream, shampoo and rinse. have.

The hair regrowth composition of this invention is used by transdermal administration, such as apply | coating or spreading directly on a scalp. The dosage should be appropriately determined according to age or individual difference or the dosage form or form thereof, but the dosage for general adults is preferably administered 1-2 ml twice a day.

Hereinafter, the present invention will be described in more detail with reference to the following examples, but the present invention is not limited by the following examples.

Preparation Example 1 Low Molecular Weight of Beta Glucan

Low molecular weight beta- (1,3 / 1,6) glucan was prepared using beta- (1,3 / 1,6) glucan extracted from Sacchromyces cervisiae yeast as follows.

6 g of beta- (1,3 / 1,6) glucan powder was suspended in 150 ml of 85% formic acid, followed by hydrolysis reaction at 88 ° C. for 20 minutes. Under these conditions, beta- (1,3 / 1,6) glucan powder is partially hydrolyzed or dissolved into water-soluble beta- (1,3 / 1,6) glucan with a planned molecular weight distribution. The dissolved beta- (1,3 / 1,6) glucan was precipitated with 1.5 times ethanol and the water-soluble beta- (1,3 / 1,6) glucan was isolated by centrifugation or filtration. Water-soluble beta- (1,3 / 1,6) glucan was dissolved in the same amount of distilled water, and residual formic acid was removed by heating for 3 hours, and water-soluble beta- (1,3 / 1,6) by ultrafiltration. Glucan was purified to have a molecular weight of 30,000 to 100,000 Da.

Preparation Example 2 Preparation of Stabilized Vitamin C Complex Aqueous Solution

5 g of vitamin C was dissolved in 5 g of low molecular weight beta glucan and 5 g of trehalose and 85 g of purified water prepared in Preparation Example 1 to obtain a stabilized 5% aqueous solution of vitamin C complex.

Preparation Example 3 Preparation of Situary Mushroom Mycelium Extract

A solid medium consisting of 40 parts by weight of mulberry sawdust, 40 parts by weight of alder sawdust and 20 parts by weight of rice bran is placed in a 1 L plastic container, sterilized at 120 ° C. for 30 minutes, cooled, and then inoculated with spawning mushrooms (Phellinus linteus). Incubate for 1-2 months in a culture room adjusted to a temperature of 20-25 ° C. and a humidity of 80%. In this way, the fruiting bodies produced out of the incubator were harvested after the mycelia were multiplied in the solid medium, and the solid medium containing the mycelium remaining in the incubator was pulverized so that the amount passed through the 12 meshes was 30 parts by weight or less. 1 kg of pulverized solid medium added with 5 L of pure water was heated at 95 ° C. for 30 minutes to denature the autosomal enzyme and fiber protein in the mycelium, and then cooled. The pH of the mixture was adjusted to 4.5 and the temperature was adjusted to 40 ° C. After that, 2.0 g of a commercial cellulase enzyme was added and the enzyme reaction was performed while stirring at 150 rpm for 60 minutes. After the enzymatic reaction was completed, the mixture was heated at 95 ° C. for 60 minutes to inactivate the enzyme and proceed with hot water extraction. After the extraction was completed, the mixed solution was naturally cooled and then centrifuged to remove the solids. Reverse osmosis membrane permeation (removal of low molecular weight substances having a molecular weight of 1,000 Da or less) and concentration were used as powdery fungus mycelium extracts which were dried and lyophilized. The yield at this time was 100 g, and the content of water-soluble beta glucan was about 0.5%.

[Examples 1-3, Comparative Examples 1-3] Preparation of Hair Regrowth Composition

The hair tonic type hair restorer of the present invention was prepared by dissolving and solubilizing each component by using the components and the formulation shown in Table 1 below. The low molecular weight beta glucan was used as the molecular weight of 30,000 to 100,000 Da obtained in Preparation Example 1, the situation mushroom mycelium extract was used as the situation mushroom mycelium extract obtained in Preparation Example 3.

TABLE 1

Test Example 1 Stabilization Test of Vitamin C

The initial titer of vitamin C in the hair repellent composition of Examples 1-3 and Comparative Examples 1-3 was 100, and the titer of vitamin C after one month was measured, and the results are shown in Table 2 below. The titer was determined relative to the amount using the peak height appearing at 266 nm using an ultraviolet spectrometer.

TABLE 2

Examples 1-3 containing the low molecular weight beta glucan and trehalose stabilized vitamin C complex from the stabilization test results of vitamin C of Table 2, but a slight change depending on the content of beta glucan, but at room temperature 1 After months, the remaining potency was high, above 90, and even at 45 ° C. However, in Comparative Examples 1 to 3, the residual titer was very low, and the browning phenomenon of the Comparative Example was also severe compared to the Example.

In the case of the hair restorer compositions of Examples 1 to 3 containing low molecular weight beta glucan and trehalose stabilized therefrom, the alteration and destruction of the stabilized vitamin C complex component in the composition does not occur, but also the content thereof. It can be confirmed that it maintains a stable state where no change occurs.

Test Example 2 Hair Growth Effect Test by Human

Sixty male and female alopecia patients were divided into six groups, each group having similar types and severity, and treated with the hair regrowth composition prepared in Examples 1 to 3 and Comparative Examples 1 to 3 for each group. Evaluated. Scalp administration was performed twice a day for 6 months, and hair growth was evaluated after 3 months and 6 months.

Judgment criteria

1. High effect-newborn hair is visible (hair growth, 硬 毛).

2. Moderate effect-Newborn hair is visible (down, hairy).

3. Slightly effective-The number of hair loss is reduced.

4. No effect-no change is seen.

The test results are shown in Table 3.

TABLE 3

As can be seen from the results of Table 3, the hair restorer of Examples 1 to 3 according to the present invention contains a vitamin C complex stabilized from beta glucan and a nutrient-activated trehalose to activate hair follicles, and the hair growth effect is at 3 months of treatment. Although it persisted well at 6 months, it contained beta glucan of Comparative Example 1, which showed a slight hair growth effect, but did not contain trehalose, which did not stabilize vitamin C, resulting in sebum produced by the division of hair follicle cells. Accumulation of lipid peroxide in the scalp prevents hair from growing, and it can be seen that hair growth, hair growth effect and hair loss prevention are not great.

In addition, Comparative Examples 2 and 3 do not contain beta glucan, so that the hair follicles and hair growth effects are not shown at all or do not activate the atrophy hair follicles in the long-term rest state, especially in the case of Comparative Example 3 It does not contain both beta glucan and trehalose, so it did not activate hair follicles or stabilize vitamin C, so there was no hair growth, hair growth and hair loss prevention, and no vitamin C addition effect.

When the low molecular weighted beta glucan of Example 1 and stabilized from trehalose containing the vitamin C complex and the situation mushroom mycelium extract is extracted from yeast and low molecular weight beta glucan has excellent absorption ability to the scalp, the immunity of beta glucan It activates atrophic hair follicles in prolonged periods of rest due to hair loss by augmentation, and simultaneously supplies trehalose as a nutrient source to activated hair follicles, thereby enhancing the division of hair follicle cells, and the resulting sebum causes lipid peroxide in the scalp. As a result of a series of processes to prevent accumulation by the stabilized vitamin C complex, new hair is grown by resting breakage of hair follicle remodeling, resulting in excellent hair growth and hair growth effects.

As described above, according to the present invention, active cell division of hair follicles is achieved by activating atrophic hair follicles in a long-term resting state by simultaneously boosting immunity of beta glucan, and simultaneously supplying trehalose as a nutrient to activated hair follicles. In this case, it is possible to prevent hair loss and hair loss by restraining hair follicles by regenerating hair follicles through a series of processes to prevent sebum from accumulating in the scalp into lipid peroxide using a stabilized complex of vitamin C or vitamin C derivatives. It is expected to be effective and can be used as an excellent hair restorer with no side effects on the scalp.

Claims (6)

Stabilized vitamin C or Sodium ascorbyl phosphate, Magnesium ascorbyl phosphate, Ascorbyl palmitate, Ascorbyl dipalmitate and Ascorbyl glucoside glucoside 0.1 to 20% by weight of a complex of stabilized vitamin C derivatives which is at least one selected from the group consisting of: Mushroom mushroom mycelium extract 0.1 to 10% by weight; And the remainder consisting of at least one selected from purified water, ethanol or isopropanol, wherein the stabilized complex of vitamin C or vitamin C derivatives is extracted from yeast and stabilized from low molecular weight beta glucan and trehalose having a molecular weight of 30,000 to 100,000 Da. Hair regrowth composition, characterized in that. The method of claim 1, The stabilized complex of vitamin C or vitamin C derivatives is extracted from yeast from 0.1 to 20% by weight of vitamin C or vitamin C derivatives from 0.01 to 10% by weight of beta glucan and low molecular weight of 30,000 to 100,000 Da and from 0.1 to trehalose Hair-repellent composition characterized in that it is an aqueous solution stabilized at 10% by weight. delete The method of claim 2, 0.1 to 10% by weight of the stabilized complex of vitamin C or vitamin C derivatives; Mushroom mushroom mycelium extract 0.1 to 5% by weight; And the remainder is at least one selected from purified water, ethanol or isopropanol. The method of claim 2, Low molecular weight beta glucan extracted from the yeast is selected from beta- (1,3 / 1,6) glucan or carboxymethyl beta- (1,3 / 1,6) glucan, or mixtures thereof Composition. For hair growth prevention, hair loss prevention or hair growth selected from hair tonics, hair lotions, hair creams, shampoos and rinses containing the hair regrowth composition according to any one of claims 1, 2, 4 and 5. Skin external preparation composition.