KR20040084393A - A method and competition for hair revival - Google Patents

Abstract

PURPOSE: Provided are a method for hair regrowth by using immune strengthening activity of beta-glucan and a composition of hair growing agent having no adverse side effect on the scalp and the human body. CONSTITUTION: The method for hair regrowth is characterized in that pores on the scalp is activated by immune strengthening activity of BRM; the pores are regenerated by supplying nutritive, and the accumulation of sebum on the scalp caused by lipid peroxide is prevented by antioxidant, wherein the sebum is released by the cell division of the regenerated pores.

Description

A method and competition for hair revival

The present invention relates to a method for regenerating hair in a resting state, and to a composition thereof, wherein the hair follicles are regenerated by activating hair follicles atrophy due to hair loss using beta glucan's immunity enhancing action and supplying sugars as nutrients to the activated hair follicles. Of the hair by the resting phase breakdown effect of converting the resting phase of the hair cycle into the growing phase by preventing antioxidants from accumulating sebum secreted by active cell division of the regenerated hair follicles into lipid peroxide in the scalp. It is to provide a regrowth composition and hair loss prevention as well as a hair regrowth composition having a certain hair growth effect and no side effects to the human body.

Hair loss from the scalp is caused by a number of factors, including internal factors such as hereditary constitution or the action of testosterone, or external factors such as mental stress in everyday life and the accumulation of lipid peroxide in the scalp. It is known that the factors involve complex hair loss symptoms. In recent years, hair loss in young people, including diffuse hair loss in women as well as male hair loss has been gradually spreading, and many kinds of hair growth or hair growth agents are commercially available to improve the hair loss phenomenon.

The main components used in commercial hair growth or hair growth agents are men who attach to vasodilation agents (such as capronium chloride, minoxidil, and extracts of various plants) or dermal papilla to circulate enough blood in the scalp and drop hairs. Hormones (female hormones such as estrogen, estradiol, progesterone, etc.) or testosterone activation inhibitors (pentadecanoic acid, fenasteride) for inhibiting the action of hormones. For example, there are two types of drugs approved by the US Food and Drug Administration (FDA) for hair loss treatment. Minoxidil, a treatment used for hair loss, is used for vasodilator action, and oral propesia is used for inhibiting the activation of male hormone based on finasteride. As a result, it is widely used as an agent having excellent hair loss prevention effect. However, most of the hair growth and hair growth agents described above have some effects on the prevention of hair loss, but the effects related to hair growth were not necessarily satisfactory. In other words, these preparations are effective only in the area where the hair roots are activated, so the hair loss prevention effect is considerable, but the hair regeneration, or hair growth effect, of the resting state is insignificant, and the hair loss has already progressed, which has no effect on the bald hair. It is known.

Hair is a growth cycle → degenerator → restor → growth hair cycle. Alopecia refers to a long resting period and a short growing period. When the resting period is prolonged, hair follicles contract and hair regeneration is almost impossible. It is the technical problem of the present invention to solve this problem. While most commercially available formulations expect only hair loss prevention effects of growing hair, the present invention prevents hair loss by regenerating hair follicles that have been shrunk for a long period of time and converting the resting phase to growing phase in the above-described hair cycle. Of course, the main purpose of the present invention is to enable the regeneration of hair and to develop a hair regrowth agent having no side effects to the human body.

In the case of alopecia areata, in which one or several areas of the scalp are suddenly lost, it is known that the hair follicle is attacked by lymphocytes by the modulation of the immune system and the developmental state is suddenly stopped. In this regard, some scientists see baldness as one of 'autoimmune diseases' such as alopecia areata and suggest that male hormones (dihydrotestosterone, DHT) cause an immune response and destroy the hair roots. In other words, in people with alopecia, white blood cells are recognized as external proteins to remove hair follicles, and autologous antibodies are generated to attack hair follicles. When autoantibodies are produced, the thymus contracts, which weakens the function of the immune system. As a result, hair follicles shrink, leaving hair thinner and less dense. According to a recent Japanese Laid-Open Patent Publication (2002-080494), the immune-enhancing action of the peptide extracted from soybean has an excellent effect on the prevention of hair loss caused by side effects caused by the use of anticancer drugs. The role of sebum is also emphasized as one of the main causes of hair loss. Sebum secreted into the scalp from the hair follicles during the growth phase is hardened by generating free radicals or peroxide in the scalp layer by irradiation with ultraviolet rays, and the hardened sebum blocks the pores, preventing the normal growth of the hair or forming Necrosis will be brought to promote hair loss. Therefore, in the present invention, a series of tests have been conducted to solve the drawbacks of the prior art and to propose a new hair regeneration method that has not been published so far, based on these findings. In other words, the present invention is a hair loss phenomenon from the perspective of immune diseases, and as a solution for this, by the method of exerting an 'autoimmune neutralization effect' by immunity enhancement, hair loss as well as general hair loss patients are greatly reduced. By activating even smooth bald hair follicles and simultaneously supplying sugars as nutrients to the activated hair follicles, hair follicles are regenerated and sebum secreted by active cell division of the regenerated hair follicles accumulates as lipid peroxide from the scalp using antioxidants. By preventing the rest period of the hair cycle is converted to the growth phase by preventing the hair loss, as well as to obtain a sure hair growth effect.

1 shows a method for regenerating hair in the resting phase on the hair cycle.

The mechanism of the hair regeneration method of the present invention will be described with reference to FIG.

Figure 1 shows the hair regeneration element in the present invention, by the 'autoimmune neutralizing effect' of BRM (Biological Response Modifier, biological response modifiers) to increase the immunity to hair follicles at rest during the hair cycle (hair cycle) Hair follicles are regenerated by activating the hair follicles and simultaneously supplying sugars as nutrients to the activated hair follicles, and antioxidants prevent sebum secreted by active cell division of the regenerated hair follicles from the scalp as lipid peroxide from the scalp. Is showing growth of hair as it transitions to growth.

In general, for the purpose of activating immunity, the method of treating intractable diseases such as cancer is called immunotherapy and the following are used. BRM that increases immunity as a natural material, not synthetic chemicals, stimulates the immune system to change the biological response of the host, and thus has various physiological effects. Especially, it is used in the treatment of various cancer patients in combination with chemotherapy. have. The polysaccharides extracted from mushrooms are known as krestin, lentinan, beta glucan, and active hexose correlated compounds (AHCC). In particular, AHCC is orally administered to various types of cancer patients, and there is no side effect as well as cancer treatment by immunity enhancement, and it is characterized by alleviating side effects such as vomiting, hair loss, and pain caused by anticancer drug administration. It is used as an adjuvant therapy. In the present invention, a method of regenerating bald hair with a significant amount of hair loss, and the hair follicle cells in the long-term rest state have a property similar to that of normal cells whose immune function is weakened by cancer cells in cancer patients. The method of activating hair follicles by 'autoimmune neutralizing effect' was adopted by applying BRM directly to the scalp.

In the present invention, according to the hair regeneration method of Figure 1 beta glucan is selected as a substance promoting the activity of the immune system from the above-described BRM, and this is carried out a clinical trial on smooth bald baldness shrinking hair follicles including patients with general alopecia As a result, hair loss prevention effect was obtained even from Min baldness, which was not expected until now. Hereinafter, the present invention will be described in more detail.

As shown in Fig. 1, the hair regrowth composition of the present invention comprises (a) 0.01 to 20% by weight of beta glucan which activates hair follicles by immune enhancing action, and (b) sugars which supply nutrients to activated hair follicles, glucose and chisil. Sebum secreted by 0.1-20% by weight of at least one selected from monosaccharides such as loose, mannose and arabinose and disaccharides such as maltose, sucrose, cellobiose and trehalose (c) promoting cell division of hair follicles Is an antioxidant that prevents the accumulation of lipid peroxide in the scalp, characterized in that it contains 0.1 to 20% by weight of one or more selected from vegetable polyphenols such as flavonoids, tannic acid, glutinous acid, catechin, ebicatechin, and rutin. .

Beta glucan (a), which acts to activate the hair follicle cells in the resting phase, is not toxic to the human body, and therefore its compounding amount is not limited and can be selected and used in a wide range, but the content of beta glucan is 0.01% by weight or less. When it becomes impossible to activate the hair follicle cells, and if the weight is more than 20% by weight, there is no big difference in the effect, but there is an economic disadvantage, so the content of beta glucan is used within the range of 0.01 to 20% by weight relative to the total amount of the preparation. It is suitable, Preferably it is more effective to carry out in 0.01 to 10weight% of a range.

In addition, (b) sugars and (c) antioxidants may be used alone or in combination of two or more thereof, and are not limited thereto, and are preferably used within the range of 0.1 to 20% by weight relative to the total amount of the formulation in terms of their effects. Preferably, it is more effective to be in the range of 0.1 to 10% by weight.

In addition to these main components, the hair regrowth composition of the present invention can contain various known materials normally blended with cosmetics that are expected to have hair growth and hair growth effects as needed. For example, antibacterial and refreshing agents. Moisturizers or mixtures thereof. Examples of the antimicrobial agents include hinoki chiol, chitosan, polyrigin, sodium benzoate, parabens and the like. As a coolant, for example, menthol is mentioned. Examples of the moisturizing agent include polyhydric alcohols such as glycerin, propylene glycol, 1, 3-butylene glycol, sorbitol, mannitol, and polyethylene glycol, and can be used alone or as a mixture when used. As the additive, for example, fats and oils, surfactants, alcohols, fatty acids, antioxidants, pigments, flavoring agents, ultraviolet absorbers, chelating agents, pH adjusters, buffers, purified water and the like can be appropriately selected.

The hair regrowth composition of the present invention contains the aforementioned main components and can be used in the form of various cosmetics used for hair and scalp such as hair tonic, hair lotion, hair cream, shampoo, and rinse.

The hair regrowth composition of this invention is used by transdermal administration, such as apply | coating or spreading directly on a scalp. The dosage should be appropriately determined according to age, individual difference, or the dosage form or form thereof. However, the dosage for general adults is preferably 1-2 ml twice a day. Hereinafter, the present invention will be described in more detail with reference to the following examples, but the present invention is not limited by the following examples.

Example 1-3 Preparation of Hair Regrowth Composition

Next, the hair tonic type hair regrowth agent of the present invention was prepared by dissolving and solubilizing each component by using the ingredients and the composition shown in Table 1 below.

TABLE 1

ingredient Example 1 Example 2 Example 3 Beta Glucan 1.0 0.1 0.01 Tannic acid 1.0 1.0 1.0 Maltose 1.0 1.0 1.0 glycerin 5.0 5.0 5.0 ethanol 50.0 50.0 50.0 Purified water 42.0 42.9 42.99

Test Example 1 Human Hair Growth Effect Test

40 types of alopecia patients (male and female) were divided into 4 groups so that each group was similar, and 4 samples of 50% of ethanol and 50% of ethanol were compared. Clinical trials were conducted and their effectiveness was evaluated. Scalp administration was performed twice a day for 6 months, and hair growth was evaluated after 6 months. The criterion is 1. High effect-New hair is seen (hair, hair) 2. Medium effect-New hair is visible (Fuzz, hair) 3. Slight effect-Number of hair loss 4. No effect- There is no change at all. The test results are shown in Table 2.

TABLE 2

Example 1 Example 2 Example 3 Comparative example Newborn hair (bristles) 4 2 2 0 Newborn hair (down) 3 4 2 0 Reduction of hair loss 2 2 4 2 No change One 2 2 8

From the results of Table 2, the hair growth agents of the present invention showed a higher improvement rate than the control group. Overall, 40 to 70% of the hair is shown to be regenerated, and the best effect was obtained in Example 1, where the content of beta glucan was relatively high. Meanwhile, in order to verify the hair regeneration method proposed by the present invention separately from Test Example 1, 10 people were selected from patients with alopecia areata who had smooth hair and scalp from 40's to late 60's. Test was carried out in the same manner as in Test Example 1 using the composition of 1. At 1 month or 2 months, new bristles including bristles began to appear, and at 6 months, 8 patients had hair regeneration effect. Therefore, the hair regrowth agent of the present invention activates atrophied hair follicles by immunity enhancing action of beta glucan and simultaneously supplies sugars as nutrients to the activated hair follicles, thereby regenerating the hair follicles and converting the resting period of the hair cycle to the growth phase. It was confirmed that the regeneration and as a result it is expected to bring about an excellent improvement in hair loss prevention and hair growth for alopecia patients. In addition, the hair regrowth composition of the present invention did not show side effects such as skin abnormalities of the scalp caused by the drug in any group during the six months of use in the present test.

As described above, according to the present invention, the hair follicles are regenerated and secreted by the active cell division of the regenerated hair follicles by activating atrophied hair follicles by beta-glucan's immunity enhancing action and simultaneously supplying saccharides as nutrients to the activated hair follicles. Antioxidant prevents the sebum from accumulating from the scalp to lipid peroxide using antioxidants, and it is expected to prevent hair loss and hair regrowth effect by stopping the rest period of the hair cycle to the growth phase. It is available.

Claims (7)

Sebum is secreted by the active cell division of the regenerated hair follicles by regenerating the hair follicles by activating resting hair follicles in the resting state by immune enhancing action of BRM (biological response modulator). A method of regenerating hair by resting phase breakage that converts the resting phase of the hair cycle into a growth phase while preventing accumulation of lipid peroxide in the form of an antioxidant. The method of regenerating hair according to claim 1, wherein the BRM having immunity enhancing action is beta glucan. A hair restorer composition comprising 0.01 to 20% by weight of beta glucan, 0.1 to 20% by weight of at least one sugar component selected from monosaccharides or disaccharides, and 0.1 to 20% by weight of antioxidants. The monosaccharide or the disaccharide contains at least one sugar component selected from monosaccharides such as glucose, xylose, mannose and arabinose or disaccharides such as maltose, sucrose, cellobiose and trehalose. Hair regrowth composition which consists of. 4. The hair regrowth composition according to claim 3, wherein the antioxidant contains at least one selected from vegetable polyphenols such as flavonoids, tannic acid, molar assets, catechins, epicatechins, and rutin. The hair repellent composition of Claim 3 containing 1.0 to 10.0 weight% of 1 or more sugar components chosen from monosaccharide or disaccharide with respect to 1 weight% of beta glucan. The hair restorer composition of Claim 3 which contains 1.0 to 10.0 weight% of 1 or more components chosen from vegetable polyphenols as antioxidant with respect to 1 weight% of beta glucan.