KR100728096B1 - 관절성 질환 치료제 - Google Patents

관절성 질환 치료제 Download PDF

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Publication number
KR100728096B1
KR100728096B1 KR1020017011505A KR20017011505A KR100728096B1 KR 100728096 B1 KR100728096 B1 KR 100728096B1 KR 1020017011505 A KR1020017011505 A KR 1020017011505A KR 20017011505 A KR20017011505 A KR 20017011505A KR 100728096 B1 KR100728096 B1 KR 100728096B1
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KR
South Korea
Prior art keywords
zinc
hyaluronic acid
delete delete
complex
therapeutic agent
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Expired - Fee Related
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KR1020017011505A
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English (en)
Korean (ko)
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KR20010108343A (ko
Inventor
세리자와이사오
마에카와게이세이
일리에슈야노슈
네즈밀리엘리자베트
Original Assignee
다카타 세이야쿠 가부시키카이샤
리히터 게데온 베제세티 쟈르 알티
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Application filed by 다카타 세이야쿠 가부시키카이샤, 리히터 게데온 베제세티 쟈르 알티 filed Critical 다카타 세이야쿠 가부시키카이샤
Publication of KR20010108343A publication Critical patent/KR20010108343A/ko
Application granted granted Critical
Publication of KR100728096B1 publication Critical patent/KR100728096B1/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020017011505A 1999-03-10 2000-03-10 관절성 질환 치료제 Expired - Fee Related KR100728096B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JPJP-P-1999-00063718 1999-03-10
JP06371899A JP2003089647A (ja) 1999-03-10 1999-03-10 関節性疾患治療剤

Publications (2)

Publication Number Publication Date
KR20010108343A KR20010108343A (ko) 2001-12-07
KR100728096B1 true KR100728096B1 (ko) 2007-06-14

Family

ID=13237463

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020017011505A Expired - Fee Related KR100728096B1 (ko) 1999-03-10 2000-03-10 관절성 질환 치료제

Country Status (21)

Country Link
US (1) US6608043B1 (https=)
EP (1) EP1166788B8 (https=)
JP (1) JP2003089647A (https=)
KR (1) KR100728096B1 (https=)
CN (1) CN1165315C (https=)
AT (1) ATE466584T1 (https=)
AU (1) AU2942500A (https=)
BG (1) BG65681B1 (https=)
CA (1) CA2364451C (https=)
CY (1) CY1109773T1 (https=)
CZ (1) CZ301736B6 (https=)
DE (1) DE60044341D1 (https=)
DK (1) DK1166788T3 (https=)
EA (1) EA005010B1 (https=)
EE (1) EE04660B1 (https=)
ES (1) ES2344677T3 (https=)
PL (1) PL200848B1 (https=)
PT (1) PT1166788E (https=)
SK (1) SK287223B6 (https=)
UA (1) UA72913C2 (https=)
WO (1) WO2000053194A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0303779A2 (en) * 2003-11-20 2006-02-28 Richter Gedeon Vegyeszet Pharmaceutical compositions containing hyaluronan complex for the treatment of sclerosis multiplex
ITRM20030590A1 (it) * 2003-12-22 2005-06-23 Univ Siena Formulazione a base di polimetafosfati per la cura di artropatie microcristalline.
WO2005089800A1 (ja) * 2004-03-17 2005-09-29 Locomogene, Inc. hsHRD3を含む医薬組成物
US20070099867A1 (en) * 2005-05-24 2007-05-03 Glycoscience Laboratories, Inc. Pharmaceutical agent containing hyaluronan as an active ingredient
NO20064337L (no) * 2005-09-26 2007-03-27 Glycoscience Lab Inc Farmasoytisk middel inneholdende hyaluronan som en aktiv ingrediens
JP2009091248A (ja) * 2006-01-17 2009-04-30 Toshitsu Kagaku Kenkyusho:Kk 外傷性神経障害および／または運動機能障害の治療薬
CA2641571C (en) 2006-12-05 2010-01-19 Glycoscience Laboratories, Inc. Treatment of osteoarthritis
FR2927255B1 (fr) * 2008-02-07 2011-08-12 Keysan Consulting Produits injectables biocompatibles a liberation de zinc et/ou de sel de saccharide sous forme de zinc et leurs utilisations.
US8462765B2 (en) * 2008-08-20 2013-06-11 Qualcomm Incorporated Method and apparatus to perform ranging operations for wireless stations
JP5587637B2 (ja) * 2009-04-10 2014-09-10 生化学工業株式会社 マトリックスメタロプロテアーゼ阻害剤及びその用途
HUP0900717A3 (en) 2009-11-18 2012-02-28 Richter Gedeon Nyrt Pharmaceutical composition for urological use containing zinc hyaluronate
US8524662B2 (en) 2010-12-28 2013-09-03 Depuy Mitek, Llc Compositions and methods for treating joints
US8455436B2 (en) 2010-12-28 2013-06-04 Depuy Mitek, Llc Compositions and methods for treating joints
US8398611B2 (en) 2010-12-28 2013-03-19 Depuy Mitek, Inc. Compositions and methods for treating joints
US8623839B2 (en) 2011-06-30 2014-01-07 Depuy Mitek, Llc Compositions and methods for stabilized polysaccharide formulations
ES2665254T3 (es) * 2011-07-12 2018-04-25 Holy Stone Healthcare Co., Ltd. Composiciones que comprenden ácido hialurónico para tratamiento y prevención de enfermedades relacionadas con las mucosas
US9682099B2 (en) 2015-01-20 2017-06-20 DePuy Synthes Products, Inc. Compositions and methods for treating joints

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988007060A1 (en) * 1987-03-19 1988-09-22 Arthropharm Pty. Limited Anti-inflammatory compounds and compositions

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU600483B2 (en) 1986-03-14 1990-08-16 Bio-Technology General Corporation Heavy metal salts of hyaluronic acid
US4746504A (en) * 1986-03-14 1988-05-24 Bio-Technology General Corp. Heavy metal salts of hyaluronic acid and their use as antimicrobial agents
AU616502B2 (en) * 1988-04-22 1991-10-31 Medvet Science Pty. Ltd. Treatment of inflammatory disorders in humans
HU203372B (en) 1989-02-24 1991-07-29 Richter Gedeon Vegyeszet Process for producing hyaluronic associates and pharmaceutical compositions and cosmetics comprising such active ingredient
CZ202591A3 (cs) * 1991-07-02 1993-01-13 Hypro Vyzkum Prostředek pro prevenci dekubitft a topickou terapii kožních lézt
US5744442A (en) * 1992-08-26 1998-04-28 Bristol Meyers Squibb Company Regulation of cellular invasiveness
IT1281877B1 (it) * 1995-05-10 1998-03-03 Fidia Advanced Biopolymers Srl Sali di metalli pesanti di succinil derivati dell'acido ialuronico e loro impiego come potenziali agenti terapeutici
IT1288290B1 (it) * 1996-06-21 1998-09-11 Fidia Spa In Amministrazione S Acido ialuronico autoreticolato e relative composizioni farmaceutiche per il trattamento delle artropatie
EP0834319A1 (en) * 1996-10-07 1998-04-08 Kartar Dr. Lalvani Mineral and vitamin combinations in arthritic pain

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988007060A1 (en) * 1987-03-19 1988-09-22 Arthropharm Pty. Limited Anti-inflammatory compounds and compositions

Also Published As

Publication number Publication date
CZ301736B6 (cs) 2010-06-09
BG65681B1 (bg) 2009-06-30
CA2364451A1 (en) 2000-09-14
CY1109773T1 (el) 2014-09-10
CN1343122A (zh) 2002-04-03
BG105885A (en) 2002-06-28
CA2364451C (en) 2011-08-02
EA200100963A1 (ru) 2002-02-28
CN1165315C (zh) 2004-09-08
CZ20013110A3 (cs) 2002-01-16
EP1166788A4 (en) 2007-10-10
EA005010B1 (ru) 2004-10-28
PL200848B1 (pl) 2009-02-27
SK287223B6 (sk) 2010-03-08
EP1166788B8 (en) 2010-06-16
EP1166788B1 (en) 2010-05-05
UA72913C2 (en) 2005-05-16
KR20010108343A (ko) 2001-12-07
SK12502001A3 (sk) 2002-02-05
PL350289A1 (en) 2002-12-02
EE04660B1 (et) 2006-08-15
DK1166788T3 (da) 2010-08-23
EP1166788A1 (en) 2002-01-02
AU2942500A (en) 2000-09-28
JP2003089647A (ja) 2003-03-28
ATE466584T1 (de) 2010-05-15
ES2344677T3 (es) 2010-09-03
EE200100478A (et) 2003-02-17
PT1166788E (pt) 2010-06-25
US6608043B1 (en) 2003-08-19
WO2000053194A1 (en) 2000-09-14
DE60044341D1 (de) 2010-06-17

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