KR100681482B1 - 천수근으로부터 하르파지드를 분리하는 방법 - Google Patents
천수근으로부터 하르파지드를 분리하는 방법 Download PDFInfo
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- KR100681482B1 KR100681482B1 KR1020050102609A KR20050102609A KR100681482B1 KR 100681482 B1 KR100681482 B1 KR 100681482B1 KR 1020050102609 A KR1020050102609 A KR 1020050102609A KR 20050102609 A KR20050102609 A KR 20050102609A KR 100681482 B1 KR100681482 B1 KR 100681482B1
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- harpazide
- column chromatography
- harpagoside
- extract
- separating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Description
Claims (2)
- 천수근(Harpagophytum procumbens)으로부터 추출한 하르파고시드 엑기스로부터 하르파지드를 분리하는 방법으로서,1) 상기 하르파고시드 엑기스를 소디움 메톡사이드, 소디움 에톡사이드, 포타슘 카보네이트, 소디움 카보네이트, 피리딘 및 히드라진으로 구성되는 군에서 선택되는 유기염기에 용해시켜 가수분해하여 하르파지드를 생성시키는 단계와2) 단계 1)에서 생성시킨 하르파지드를 디메틸암모늄 또는 디메틸에탄올암모늄을 교환기로 갖고, Cl-를 이온형으로 갖는 강염기성 음이온 교환수지 컬럼크로마토 그래피로 정제 및 농축시키고;메틸렌클로라이드, 메탄올 및 물의 혼합용매를 용출액으로 사용한 실리카겔 컬럼크로마토그래피로 정제 및 농축시키고;상기 농축물을 물에 용해시켜 활성탄 컬럼크로마토그래피로 정제 및 농축시킨 후 감압여과 및 동결건조를 수행하는 단계를 포함하는 방법.
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KR1020050102609A KR100681482B1 (ko) | 2005-10-28 | 2005-10-28 | 천수근으로부터 하르파지드를 분리하는 방법 |
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KR1020050102609A KR100681482B1 (ko) | 2005-10-28 | 2005-10-28 | 천수근으로부터 하르파지드를 분리하는 방법 |
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KR100681482B1 true KR100681482B1 (ko) | 2007-04-16 |
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KR1020050102609A KR100681482B1 (ko) | 2005-10-28 | 2005-10-28 | 천수근으로부터 하르파지드를 분리하는 방법 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20230126593A (ko) | 2022-02-23 | 2023-08-30 | 재단법인 자생의료재단 | 천수근 유래 엑소좀을 포함하는 근감소증 치료 또는 예방용 조성물 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR920005686A (ko) * | 1990-05-19 | 1992-04-03 | 요시다 다다오 | 슬라이드 파스너 제조 방법 |
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- 2005-10-28 KR KR1020050102609A patent/KR100681482B1/ko not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR920005686A (ko) * | 1990-05-19 | 1992-04-03 | 요시다 다다오 | 슬라이드 파스너 제조 방법 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20230126593A (ko) | 2022-02-23 | 2023-08-30 | 재단법인 자생의료재단 | 천수근 유래 엑소좀을 포함하는 근감소증 치료 또는 예방용 조성물 |
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