KR100591626B1 - 전자 혼성화 반응의 최적화 방법 및 재료 - Google Patents
전자 혼성화 반응의 최적화 방법 및 재료 Download PDFInfo
- Publication number
- KR100591626B1 KR100591626B1 KR1019997001868A KR19997001868A KR100591626B1 KR 100591626 B1 KR100591626 B1 KR 100591626B1 KR 1019997001868 A KR1019997001868 A KR 1019997001868A KR 19997001868 A KR19997001868 A KR 19997001868A KR 100591626 B1 KR100591626 B1 KR 100591626B1
- Authority
- KR
- South Korea
- Prior art keywords
- buffer
- nucleic acid
- hybridization
- dna
- low conductivity
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 50
- 238000009396 hybridization Methods 0.000 title claims abstract description 45
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Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L29/00—Semiconductor devices specially adapted for rectifying, amplifying, oscillating or switching and having potential barriers; Capacitors or resistors having potential barriers, e.g. a PN-junction depletion layer or carrier concentration layer; Details of semiconductor bodies or of electrodes thereof ; Multistep manufacturing processes therefor
- H01L29/66—Types of semiconductor device ; Multistep manufacturing processes therefor
- H01L29/66007—Multistep manufacturing processes
- H01L29/66075—Multistep manufacturing processes of devices having semiconductor bodies comprising group 14 or group 13/15 materials
- H01L29/66227—Multistep manufacturing processes of devices having semiconductor bodies comprising group 14 or group 13/15 materials the devices being controllable only by the electric current supplied or the electric potential applied, to an electrode which does not carry the current to be rectified, amplified or switched, e.g. three-terminal devices
- H01L29/66409—Unipolar field-effect transistors
- H01L29/66477—Unipolar field-effect transistors with an insulated gate, i.e. MISFET
- H01L29/6656—Unipolar field-effect transistors with an insulated gate, i.e. MISFET using multiple spacer layers, e.g. multiple sidewall spacers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6832—Enhancement of hybridisation reaction
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Power Engineering (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Biophysics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Ceramic Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Computer Hardware Design (AREA)
- Electrochemistry (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70826296A | 1996-09-06 | 1996-09-06 | |
US08/708,262 | 1996-09-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20010029477A KR20010029477A (ko) | 2001-04-06 |
KR100591626B1 true KR100591626B1 (ko) | 2006-06-20 |
Family
ID=24845074
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019997001868A KR100591626B1 (ko) | 1996-09-06 | 1997-08-18 | 전자 혼성화 반응의 최적화 방법 및 재료 |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1019711A4 (ja) |
JP (1) | JP4213216B2 (ja) |
KR (1) | KR100591626B1 (ja) |
CN (1) | CN1180248C (ja) |
AU (1) | AU723564B2 (ja) |
BR (1) | BR9712800A (ja) |
CA (1) | CA2264780C (ja) |
NZ (1) | NZ334314A (ja) |
WO (1) | WO1998010273A1 (ja) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6051380A (en) * | 1993-11-01 | 2000-04-18 | Nanogen, Inc. | Methods and procedures for molecular biological analysis and diagnostics |
US6468742B2 (en) | 1993-11-01 | 2002-10-22 | Nanogen, Inc. | Methods for determination of single nucleic acid polymorphisms using bioelectronic microchip |
US6379897B1 (en) * | 2000-11-09 | 2002-04-30 | Nanogen, Inc. | Methods for gene expression monitoring on electronic microarrays |
US5964995A (en) * | 1997-04-04 | 1999-10-12 | Caliper Technologies Corp. | Methods and systems for enhanced fluid transport |
US6238909B1 (en) * | 1999-05-04 | 2001-05-29 | Motorola, Inc. | Method and apparatus for obtaining electric field-enhanced bioconjugation |
CN1285908C (zh) * | 1999-09-27 | 2006-11-22 | 孟山都公司 | 测定种子油的方法 |
US7309581B2 (en) * | 2000-11-01 | 2007-12-18 | Sysmex Corporation | Method of staining, detection and counting bacteria, and a diluent for bacterial stain |
GB0205455D0 (en) | 2002-03-07 | 2002-04-24 | Molecular Sensing Plc | Nucleic acid probes, their synthesis and use |
US7153687B2 (en) | 2002-08-13 | 2006-12-26 | Hong Kong Dna Chips Limited | Apparatus and methods for detecting DNA in biological samples |
JP4464664B2 (ja) | 2003-06-13 | 2010-05-19 | 独立行政法人理化学研究所 | 生体分子マイクロアレイ用基板、生体分子マイクロアレイ、相互作用促進用装置および方法、ならびに、相互作用の検出方法 |
US7314542B2 (en) * | 2004-09-23 | 2008-01-01 | Nanogen, Inc. | Methods and materials for optimization of electronic transportation and hybridization reactions |
KR100785011B1 (ko) * | 2006-04-07 | 2007-12-11 | 삼성전자주식회사 | 쌍이온 화합물을 이용한 핵산 혼성화 특이성을 증가시키는방법 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4936963A (en) * | 1987-05-27 | 1990-06-26 | Abbott Laboratories | Polycationic buffers and method for gel electrophoresis of nucleic acids |
US5188963A (en) * | 1989-11-17 | 1993-02-23 | Gene Tec Corporation | Device for processing biological specimens for analysis of nucleic acids |
US6017696A (en) * | 1993-11-01 | 2000-01-25 | Nanogen, Inc. | Methods for electronic stringency control for molecular biological analysis and diagnostics |
US5585069A (en) * | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis |
DE69533554T2 (de) * | 1994-11-10 | 2005-01-27 | Orchid Biosciences, Inc. | Flüssigkeitsverteilungssystem |
-
1997
- 1997-08-18 CA CA002264780A patent/CA2264780C/en not_active Expired - Fee Related
- 1997-08-18 JP JP51267698A patent/JP4213216B2/ja not_active Expired - Lifetime
- 1997-08-18 KR KR1019997001868A patent/KR100591626B1/ko not_active IP Right Cessation
- 1997-08-18 EP EP97938378A patent/EP1019711A4/en not_active Withdrawn
- 1997-08-18 AU AU40719/97A patent/AU723564B2/en not_active Ceased
- 1997-08-18 BR BR9712800-7A patent/BR9712800A/pt unknown
- 1997-08-18 NZ NZ334314A patent/NZ334314A/xx unknown
- 1997-08-18 WO PCT/US1997/014489 patent/WO1998010273A1/en active IP Right Grant
- 1997-08-18 CN CNB97197960XA patent/CN1180248C/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2264780A1 (en) | 1998-03-12 |
EP1019711A1 (en) | 2000-07-19 |
CN1230255A (zh) | 1999-09-29 |
EP1019711A4 (en) | 2001-06-13 |
BR9712800A (pt) | 1999-11-23 |
JP4213216B2 (ja) | 2009-01-21 |
KR20010029477A (ko) | 2001-04-06 |
CN1180248C (zh) | 2004-12-15 |
WO1998010273A1 (en) | 1998-03-12 |
CA2264780C (en) | 2006-08-01 |
NZ334314A (en) | 2000-09-29 |
AU723564B2 (en) | 2000-08-31 |
AU4071997A (en) | 1998-03-26 |
JP2001501301A (ja) | 2001-01-30 |
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