KR100564714B1 - 혈관 형성을 억제하는 화합물 - Google Patents

혈관 형성을 억제하는 화합물 Download PDF

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Publication number
KR100564714B1
KR100564714B1 KR1019997000264A KR19997000264A KR100564714B1 KR 100564714 B1 KR100564714 B1 KR 100564714B1 KR 1019997000264 A KR1019997000264 A KR 1019997000264A KR 19997000264 A KR19997000264 A KR 19997000264A KR 100564714 B1 KR100564714 B1 KR 100564714B1
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KR
South Korea
Prior art keywords
dendrimer
terminated
acid
dendrimers
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019997000264A
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English (en)
Korean (ko)
Other versions
KR20000067876A (ko
Inventor
매튜즈배리로스
홀란조지
Original Assignee
바이오몰레큘라 리서치 인스티튜트 리미티드
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Publication of KR20000067876A publication Critical patent/KR20000067876A/ko
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Publication of KR100564714B1 publication Critical patent/KR100564714B1/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/36—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino acids, polyamines and polycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/795—Polymers containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/16—Dendrimers and dendritic polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Liquid Crystal Substances (AREA)
  • Chemical And Physical Treatments For Wood And The Like (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyamides (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1019997000264A 1996-07-17 1997-07-17 혈관 형성을 억제하는 화합물 Expired - Fee Related KR100564714B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPO1044 1996-07-17
AUPO1044A AUPO104496A0 (en) 1996-07-17 1996-07-17 Angiogenic inhibitory compounds

Publications (2)

Publication Number Publication Date
KR20000067876A KR20000067876A (ko) 2000-11-25
KR100564714B1 true KR100564714B1 (ko) 2006-03-28

Family

ID=3795360

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019997000264A Expired - Fee Related KR100564714B1 (ko) 1996-07-17 1997-07-17 혈관 형성을 억제하는 화합물

Country Status (15)

Country Link
US (1) US6426067B1 (enExample)
EP (1) EP0927217B1 (enExample)
JP (1) JP2000516211A (enExample)
KR (1) KR100564714B1 (enExample)
CN (1) CN1161128C (enExample)
AT (1) ATE325154T1 (enExample)
AU (1) AUPO104496A0 (enExample)
BR (1) BR9710375A (enExample)
CA (1) CA2262862C (enExample)
DE (1) DE69735810T2 (enExample)
DK (1) DK0927217T3 (enExample)
ES (1) ES2260796T3 (enExample)
NZ (1) NZ333488A (enExample)
PT (1) PT927217E (enExample)
WO (1) WO1998003573A1 (enExample)

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US7018637B2 (en) * 1998-02-23 2006-03-28 Aventis Pasteur, Inc Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines
FR2781485B1 (fr) 1998-07-21 2003-08-08 Denis Barritault Polymeres biocompatibles leur procede de preparation et les compositions les contenant
AUPP584298A0 (en) * 1998-09-14 1998-10-08 Starpharma Limited Antimicrobial and antiparasitic agents
GB0001481D0 (en) * 2000-01-21 2000-03-15 Theryte Ltd System for delivering a medicament
WO2001072297A1 (en) * 2000-03-27 2001-10-04 The Scripps Research Institute Methods for inhibiting angiogenesis and tumor growth
KR100413532B1 (ko) * 2001-02-14 2003-12-31 학교법인 포항공과대학교 폴리아민이 말단에 치환된 덴드리머 및 그 제조방법
AUPR412901A0 (en) * 2001-03-30 2001-05-03 Starpharma Limited Agents for the prevention and treatment of sexually transmitted disease s - II
AUPR412801A0 (en) 2001-03-30 2001-05-03 Starpharma Limited Agent for the prevention and treatment of sexually transmitted disease s - I
US20030135195A1 (en) * 2002-01-16 2003-07-17 Oscar Jimenez Highly lubricious hydrophilic coating utilizing dendrimers
US20030180250A1 (en) * 2002-03-22 2003-09-25 Council Of Scientific And Industrial Research Compositions and complexes containing a macromolecular compound as potential anti-inflammatory agents
EP1617808A4 (en) * 2003-04-25 2011-11-02 Penn State Res Found METHOD AND SYSTEM FOR THE SYSTEMIC DISTRIBUTION OF GROWTH-INHIBITORS OF LIPID-DERIVED BIOACTIVE COMPOUNDS
CN102653515A (zh) * 2004-06-15 2012-09-05 宝利麦迪克斯股份有限公司 聚阳离子化合物及其用途
FR2876916B1 (fr) * 2004-10-25 2007-01-05 Midi Pyrenees Incubateur Produit implantable de surface fonctionnalisee au moyen de dendrimeres a terminaisons anioniques
KR100667171B1 (ko) 2005-05-10 2007-01-12 서애희 세포내 물질전달용 ｐａｍａｍ 유도체 및 이를 이용한세포내 원하는 물질의 전달방법
GR1005807B (el) * 2005-07-13 2008-02-06 Αρισταρχος Παπαγιανναρος Ρυθμιστικο λιποσωμιακο συστημα ελεγχομενης αποδεσμευσης: νεα φαρμακοτεχνικη μορφη για εγκλωβισμο αντικαρκινικων φαρμακων με βαση την τεχνολογια των λιποσωματων και των δενδριμερων
WO2007045010A1 (en) * 2005-10-21 2007-04-26 Starpharma Pty Limited Inhibitory compounds
DE102005056592A1 (de) * 2005-11-25 2007-05-31 Basf Ag Herstellung und Verwendung von hochfunktionellen, hoch-oder hyperverzweigten Polylysinen
JP5989294B2 (ja) * 2006-01-20 2016-09-07 スターファーマ・プロプライエタリー・リミテッドＳｔａｒｐｈａｒｍａ Ｐｔｙ Ｌｔｄ 修飾高分子
ES2558875T3 (es) 2006-03-22 2016-02-09 Starpharma Pty Limited Composición anticonceptiva
DE102006036326A1 (de) * 2006-08-03 2008-02-07 Charité - Universitätsmedizin Berlin Dendritische Polyglycerolsulfate und -sulfonate und deren Verwendung bei entzündlichen Erkrankungen
EP2162283B1 (en) 2007-06-14 2015-08-12 Massachusetts Institute of Technology Self assembled films for protein and drug delivery applications
US8658148B2 (en) * 2007-06-22 2014-02-25 Genzyme Corporation Chemically modified dendrimers
US20100173871A1 (en) * 2008-08-01 2010-07-08 Centre National De La Recherche Scientifique Phosphorylated dendrimers as antiinflammatory drugs
US10106565B2 (en) 2008-08-01 2018-10-23 Centre National De La Recherche Scientifique Phosphorylated dendrimers as antiinflammatory drugs
WO2010021973A2 (en) 2008-08-17 2010-02-25 Massachusetts Institute Of Technology Controlled delivery of bioactive agents from decomposable films
JP6057987B2 (ja) * 2011-05-16 2017-01-11 スターファーマ・ピーティーワイ・リミテッド 細菌性膣炎の治療または予防の方法
US10278927B2 (en) 2012-04-23 2019-05-07 Massachusetts Institute Of Technology Stable layer-by-layer coated particles
WO2014134029A1 (en) 2013-02-26 2014-09-04 Massachusetts Institute Of Technology Nucleic acid particles, methods and use thereof
WO2014150074A1 (en) 2013-03-15 2014-09-25 Massachusetts Institute Of Technology Compositions and methods for nucleic acid delivery
US20160222173A1 (en) * 2015-01-26 2016-08-04 National Chiao Tung University Dendrimer, dendrimer having functional group and antibody
DE102017002810A1 (de) 2017-03-22 2018-09-27 Reinhard Brossmer Sialinsäurederivate mit C-C Dreifachbindung und deren Herstellung
US11419947B2 (en) 2017-10-30 2022-08-23 Massachusetts Institute Of Technology Layer-by-layer nanoparticles for cytokine therapy in cancer treatment
EP3975841A1 (en) 2019-05-30 2022-04-06 Massachusetts Institute of Technology Peptide nucleic acid functionalized hydrogel microneedles for sampling and detection of interstitial fluid nucleic acids

Citations (2)

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WO1994004165A1 (en) * 1992-08-19 1994-03-03 Merrell Dow Pharmaceuticals Inc. Antiangiogenic oligomers
WO1995034595A1 (en) * 1994-06-15 1995-12-21 Biomolecular Research Institute Ltd. Antiviral dendrimers

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US4289872A (en) * 1979-04-06 1981-09-15 Allied Corporation Macromolecular highly branched homogeneous compound based on lysine units
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Publication number Priority date Publication date Assignee Title
WO1994004165A1 (en) * 1992-08-19 1994-03-03 Merrell Dow Pharmaceuticals Inc. Antiangiogenic oligomers
WO1995034595A1 (en) * 1994-06-15 1995-12-21 Biomolecular Research Institute Ltd. Antiviral dendrimers

Also Published As

Publication number Publication date
DE69735810T2 (de) 2006-12-21
CN1225654A (zh) 1999-08-11
EP0927217B1 (en) 2006-05-03
US6426067B1 (en) 2002-07-30
JP2000516211A (ja) 2000-12-05
EP0927217A4 (en) 2003-04-23
PT927217E (pt) 2006-08-31
AU715761B2 (en) 2000-02-10
NZ333488A (en) 2000-07-28
ES2260796T3 (es) 2006-11-01
CN1161128C (zh) 2004-08-11
BR9710375A (pt) 1999-08-17
ATE325154T1 (de) 2006-06-15
DE69735810D1 (de) 2006-06-08
DK0927217T3 (da) 2006-08-14
WO1998003573A1 (en) 1998-01-29
CA2262862A1 (en) 1998-01-29
CA2262862C (en) 2005-10-04
EP0927217A1 (en) 1999-07-07
AUPO104496A0 (en) 1996-08-08
KR20000067876A (ko) 2000-11-25
AU3330297A (en) 1998-02-10

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