KR100530683B1 - 세린 프로테이나제 억제 활성을 갖는 소수성 테트라사이클린을 포함하는 약제학적 조성물 - Google Patents

세린 프로테이나제 억제 활성을 갖는 소수성 테트라사이클린을 포함하는 약제학적 조성물 Download PDF

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Publication number
KR100530683B1
KR100530683B1 KR10-1999-7008325A KR19997008325A KR100530683B1 KR 100530683 B1 KR100530683 B1 KR 100530683B1 KR 19997008325 A KR19997008325 A KR 19997008325A KR 100530683 B1 KR100530683 B1 KR 100530683B1
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South Korea
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tetracycline
pharmaceutical composition
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activity
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KR10-1999-7008325A
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Korean (ko)
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KR20000076231A (ko
Inventor
사이몬샌포드알
로어머엘리자베쓰제이
골럽로른엠
라마무르티눈가바람에스
Original Assignee
더 리서치 파운데이션 오브 스테이트 유니버시티 오브 뉴욕
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Publication of KR20000076231A publication Critical patent/KR20000076231A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
KR10-1999-7008325A 1997-03-13 1998-02-26 세린 프로테이나제 억제 활성을 갖는 소수성 테트라사이클린을 포함하는 약제학적 조성물 Expired - Fee Related KR100530683B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/816,551 US5773430A (en) 1997-03-13 1997-03-13 Serine proteinase inhibitory activity by hydrophobic tetracycline
US08/816,551 1997-03-13
US8/816,551 1997-03-13
PCT/US1998/003782 WO1998040079A1 (en) 1997-03-13 1998-02-26 Serine proteinase inhibitory activity by hydrophobic tetracycline

Publications (2)

Publication Number Publication Date
KR20000076231A KR20000076231A (ko) 2000-12-26
KR100530683B1 true KR100530683B1 (ko) 2005-11-24

Family

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Application Number Title Priority Date Filing Date
KR10-1999-7008325A Expired - Fee Related KR100530683B1 (ko) 1997-03-13 1998-02-26 세린 프로테이나제 억제 활성을 갖는 소수성 테트라사이클린을 포함하는 약제학적 조성물

Country Status (13)

Country Link
US (1) US5773430A (https=)
EP (1) EP0975349B1 (https=)
JP (1) JP4339411B2 (https=)
KR (1) KR100530683B1 (https=)
AT (1) ATE292972T1 (https=)
AU (1) AU733308B2 (https=)
CA (1) CA2283071C (https=)
DE (1) DE69829748T2 (https=)
DK (1) DK0975349T3 (https=)
ES (1) ES2241124T3 (https=)
NZ (1) NZ337578A (https=)
PT (1) PT975349E (https=)
WO (1) WO1998040079A1 (https=)

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US6887678B2 (en) * 1998-12-02 2005-05-03 Cindy L. Bristow Method for the quantitative determination of proteinase inhibitors
JP2002543122A (ja) * 1999-04-30 2002-12-17 エイピーティー ファーマスーティカルズ エルエルスィー 抗マラリア治療剤についての新規使用
GB0004531D0 (en) * 2000-02-25 2000-04-19 Richards Andrew J M The treatment of respiratory diseases
US6627785B1 (en) * 2000-02-29 2003-09-30 Virginia Commwealth University Wound dressings with protease-lowering activity
US6503892B2 (en) * 2000-04-26 2003-01-07 New England Medical Center Hospitals Inc. Method of using matrix metalloproteinase inhibitors in filtering blebs following glaucoma filtering surgery and in the treatment of ischemic damage to the retina and optic nerve
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US7247704B2 (en) * 2000-12-18 2007-07-24 Arriva Pharmaceuticals, Inc. Multifunctional protease inhibitors and their use in treatment of disease
EP2311440A1 (en) * 2001-04-05 2011-04-20 Collagenex Pharmaceuticals, Inc. Controlled delivery of tetracycline compounds and tetracycline derivatives
EP1801240A1 (en) * 2001-06-05 2007-06-27 Auckland Uniservices Limited Methods and compositions for assessment of pulmonary function and disorders
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
EP2327409A1 (en) 2001-07-13 2011-06-01 Paratek Pharmaceuticals, Inc. Tetracycline compound having target therapeutic activities
US20030181371A1 (en) * 2001-12-28 2003-09-25 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collajolie
ES2551708T3 (es) 2002-01-08 2015-11-23 Paratek Pharmaceuticals, Inc. Compuestos de 4-desdimetilamino tetraciclina
EP2311451A1 (en) 2002-03-08 2011-04-20 Paratek Pharmaceuticals, Inc. Amino-methyl substituted tetracycline compounds
EP1503981A4 (en) 2002-03-21 2007-08-15 Paratek Pharm Innc SUBSTITUTED TETRACYCLINE COMPOUNDS
AU2003261161B2 (en) 2002-07-12 2009-09-10 Paratek Pharmaceuticals, Inc 3, 10, and 12a substituted tetracycline compounds
US20040092491A1 (en) * 2002-11-09 2004-05-13 The Research Foundation Of State University Of New York Method of treating sepsis-induced ARDS
WO2004091483A2 (en) 2003-04-07 2004-10-28 Shire Laboratories, Inc. Once daily formulations of tetracyclines
AU2004240629B2 (en) * 2003-05-16 2010-02-25 Arriva Pharmaceuticals, Inc. Treatment of respiratory disease by inhalation of synthetic matrix metalloprotease inhibitors
US20050143352A1 (en) 2003-07-09 2005-06-30 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
AU2004259661B2 (en) 2003-07-09 2011-11-10 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
JP5010284B2 (ja) * 2004-01-15 2012-08-29 パラテック ファーマシューティカルズ インコーポレイテッド テトラサイクリン化合物の芳香族ａ環誘導体
EP2033950A1 (en) 2004-10-25 2009-03-11 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EP1805134B1 (en) 2004-10-25 2012-06-20 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
US20060269946A1 (en) * 2005-05-10 2006-11-30 Young Robert P Methods and compositions for assessment of pulmonary function and disorders
KR20080011292A (ko) * 2005-05-19 2008-02-01 시너젠즈 바이오사이언스 리미티드 유전자 다형 분석을 사용하여 폐암 발생 위험을 평가하는방법
EP1888779A4 (en) * 2005-05-20 2009-06-10 Synergenz Bioscience Ltd METHOD FOR THE ANALYSIS OF POLYMORPHISMS AND USES THEREOF
US20070093455A1 (en) * 2005-07-21 2007-04-26 Paul Abato 10-substituted tetracyclines and methods of use thereof
US8795730B2 (en) * 2006-01-31 2014-08-05 David John Vachon Compositions and methods for promoting the healing of tissue of multicellular organisms
WO2008079339A2 (en) 2006-12-21 2008-07-03 Paratek Pharmaceuticals, Inc. Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections
CA2892739A1 (en) 2006-12-21 2008-07-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
EP2216323A3 (en) * 2007-04-27 2010-12-29 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
EP2176216B1 (en) * 2007-07-06 2012-04-25 Paratek Pharmaceuticals, Inc. Methods for synthesizing 9-substituted minocycline
TWI680117B (zh) 2008-05-19 2019-12-21 派洛泰克藥物股份有限公司 四環素化合物之甲苯磺酸鹽及同素異形體
KR101746795B1 (ko) 2008-08-08 2017-06-13 테트라페이즈 파마슈티컬스, 인코포레이티드 Ｃ７-플루오로 치환된 테트라시클린 화합물
JP2012501456A (ja) 2008-08-28 2012-01-19 アスチュート メディカル，インコーポレイテッド 腎損傷および腎不全の診断および予後のための方法および組成物
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US20250177318A1 (en) * 2022-01-04 2025-06-05 The Research Foundation For The State University Of New York Cmt-3 formulations and methods of using the same

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Publication number Publication date
EP0975349B1 (en) 2005-04-13
DE69829748T2 (de) 2006-03-09
AU733308B2 (en) 2001-05-10
JP4339411B2 (ja) 2009-10-07
DK0975349T3 (da) 2005-08-01
EP0975349A4 (en) 2002-10-30
CA2283071A1 (en) 1998-09-17
ATE292972T1 (de) 2005-04-15
DE69829748D1 (de) 2005-05-19
ES2241124T3 (es) 2005-10-16
CA2283071C (en) 2009-01-27
AU6669898A (en) 1998-09-29
JP2001524948A (ja) 2001-12-04
PT975349E (pt) 2005-08-31
EP0975349A1 (en) 2000-02-02
NZ337578A (en) 2001-08-31
KR20000076231A (ko) 2000-12-26
US5773430A (en) 1998-06-30
WO1998040079A1 (en) 1998-09-17

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