KR100529270B1 - 혈관신생 및 심혈관형성의 촉진 또는 억제 - Google Patents

혈관신생 및 심혈관형성의 촉진 또는 억제 Download PDF

Info

Publication number
KR100529270B1
KR100529270B1 KR10-2001-7006818A KR20017006818A KR100529270B1 KR 100529270 B1 KR100529270 B1 KR 100529270B1 KR 20017006818 A KR20017006818 A KR 20017006818A KR 100529270 B1 KR100529270 B1 KR 100529270B1
Authority
KR
South Korea
Prior art keywords
polypeptide
seq
acid sequence
amino acid
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
KR10-2001-7006818A
Other languages
English (en)
Korean (ko)
Other versions
KR20010086070A (ko
Inventor
아비 제이. 애쉬케나지
케빈 피. 베이커
나폴레온 페라라
한스피터 저버
케네쓰 제이. 힐란
오드리 고다드
폴 제이. 고다우스키
오스틴 엘. 거니
로버트 디. 클레인
소피아 에스. 쿠오
니콜라스 에프. 파오니
빅토리아 스미스
콜린 케이. 와타나베
피. 믹키 윌리암스
윌리암 아이. 우드
Original Assignee
제넨테크, 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1998/025108 external-priority patent/WO1999028462A2/en
Priority claimed from PCT/US1999/005028 external-priority patent/WO1999046281A2/en
Priority claimed from PCT/US1999/012252 external-priority patent/WO1999063088A2/en
Priority claimed from PCT/US1999/020111 external-priority patent/WO2000012708A2/en
Priority claimed from PCT/US1999/020594 external-priority patent/WO2000015666A2/en
Priority claimed from PCT/US1999/020944 external-priority patent/WO2000015792A2/en
Priority claimed from PCT/US1999/021090 external-priority patent/WO2000015796A2/en
Priority claimed from PCT/US1999/021547 external-priority patent/WO2000015797A2/en
Priority claimed from PCT/US1999/023089 external-priority patent/WO2000021996A2/en
Application filed by 제넨테크, 인크. filed Critical 제넨테크, 인크.
Publication of KR20010086070A publication Critical patent/KR20010086070A/ko
Publication of KR100529270B1 publication Critical patent/KR100529270B1/ko
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
    • C12N9/6408—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21034—Plasma kallikrein (3.4.21.34)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Plant Pathology (AREA)
KR10-2001-7006818A 1998-12-01 1999-11-30 혈관신생 및 심혈관형성의 촉진 또는 억제 Expired - Lifetime KR100529270B1 (ko)

Applications Claiming Priority (36)

Application Number Priority Date Filing Date Title
USPCT/US98/25108 1998-12-01
PCT/US1998/025108 WO1999028462A2 (en) 1997-12-03 1998-12-01 Polypeptides and nucleic acids encoding the same
US11285098P 1998-12-16 1998-12-16
US60/112,850 1998-12-16
US11555499P 1999-01-12 1999-01-12
US60/115,554 1999-01-12
USPCT/US99/05028 1999-03-08
PCT/US1999/005028 WO1999046281A2 (en) 1998-03-10 1999-03-08 Novel polypeptides and nucleic acids encoding the same
US12395799P 1999-03-12 1999-03-12
US60/123,957 1999-03-12
US13144599P 1999-04-28 1999-04-28
US60/131,445 1999-04-28
US13428799P 1999-05-14 1999-05-14
US60/134,287 1999-05-14
PCT/US1999/012252 WO1999063088A2 (en) 1998-06-02 1999-06-02 Membrane-bound proteins and nucleic acids encoding the same
USPCT/US99/12252 1999-06-02
US14103799P 1999-06-23 1999-06-23
US60/141,037 1999-06-23
US14475899P 1999-07-20 1999-07-20
US60/144,758 1999-07-20
US14569899P 1999-07-26 1999-07-26
US60/145,698 1999-07-26
PCT/US1999/020111 WO2000012708A2 (en) 1998-09-01 1999-09-01 Further pro polypeptides and sequences thereof
USPCT/US99/20111 1999-09-01
USPCT/US99/20594 1999-09-08
PCT/US1999/020594 WO2000015666A2 (en) 1998-09-10 1999-09-08 Compositions and methods for the treatment of tumors
PCT/US1999/020944 WO2000015792A2 (en) 1998-09-14 1999-09-13 Promotion or inhibition of angiogenesis and cardiovascularization
USPCT/US99/20944 1999-09-13
PCT/US1999/021090 WO2000015796A2 (en) 1998-09-16 1999-09-15 Secreted and transmembrane polypeptides and nucleic acids encoding the same
USPCT/US99/21547 1999-09-15
PCT/US1999/021547 WO2000015797A2 (en) 1998-09-17 1999-09-15 Compositions and methods for the treatment of immune related diseases
USPCT/US99/21090 1999-09-15
USPCT/US99/23089 1999-10-05
PCT/US1999/023089 WO2000021996A2 (en) 1998-10-13 1999-10-05 Methods and compositions for inhibiting neoplastic cell growth
US16250699P 1999-10-29 1999-10-29
US60/162,506 1999-10-29

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020047012987A Division KR100543857B1 (ko) 1999-09-01 1999-11-30 혈관신생 및 심혈관형성의 촉진 또는 억제

Publications (2)

Publication Number Publication Date
KR20010086070A KR20010086070A (ko) 2001-09-07
KR100529270B1 true KR100529270B1 (ko) 2005-11-21

Family

ID=37398593

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-2001-7006818A Expired - Lifetime KR100529270B1 (ko) 1998-12-01 1999-11-30 혈관신생 및 심혈관형성의 촉진 또는 억제

Country Status (9)

Country Link
EP (1) EP1135485B1 (https=)
JP (3) JP3695642B2 (https=)
KR (1) KR100529270B1 (https=)
AT (1) ATE458050T1 (https=)
AU (1) AU771751C (https=)
CA (1) CA2347835A1 (https=)
IL (1) IL202176A0 (https=)
MX (1) MXPA01005169A (https=)
WO (1) WO2000032221A2 (https=)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001019991A1 (en) * 1999-09-15 2001-03-22 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
WO2000053760A2 (en) * 1999-03-12 2000-09-14 Genentech, Inc. Method of preventing the death of retinal neurons and treating ocular diseases
WO2002008284A2 (en) * 2000-07-20 2002-01-31 Genentech, Inc. Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
US7285267B2 (en) 1997-01-14 2007-10-23 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6α & 6β
CA2277925A1 (en) 1997-01-14 1998-07-16 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6.alpha. and 6.beta.
US20030068623A1 (en) * 1997-06-16 2003-04-10 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
JP4303883B2 (ja) 1997-09-18 2009-07-29 ジェネンテック・インコーポレーテッド ＤｃＲ３ポリペプチドというＴＮＦＲ相同体
US6503184B1 (en) 1997-10-21 2003-01-07 Human Genome Sciences, Inc. Human tumor necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2
US6689607B2 (en) 1997-10-21 2004-02-10 Human Genome Sciences, Inc. Human tumor, necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2
ATE405651T1 (de) 1998-03-17 2008-09-15 Genentech Inc Zu vegf und bmp1 homologe polypeptide
US6949339B1 (en) 1998-05-21 2005-09-27 Diadexus, Inc. Method of diagnosing, monitoring, and staging colon cancer
CA2331154A1 (en) 1998-06-16 1999-12-23 Human Genome Sciences, Inc. Polypeptides having sequence identity with acid labile subunit of insulin-like growth factor
US7014996B1 (en) 1998-10-02 2006-03-21 Diadexus, Inc. Method of diagnosing, monitoring, staging, imaging and treating gynecologic cancers
DE69934903T2 (de) 1998-11-10 2007-10-18 Emory University Mitogene regulatoren
US6432673B1 (en) 1998-12-07 2002-08-13 Zymogenetics, Inc. Growth factor homolog ZVEGF3
CA2354610A1 (en) * 1998-12-09 2000-06-15 Shionogi & Co., Ltd. Human secretory phospholipase a2
EP1155117A4 (en) * 1998-12-30 2003-05-14 Millennium Pharm Inc SECRETED PROTEINS AND NUCLEIC ACIDS ENCODING THESE PROTEINS
KR100553300B1 (ko) * 1999-03-08 2006-02-20 제넨테크, 인크. 혈관신생 및 심혈관형성의 촉진 또는 억제 방법
CA2362885A1 (en) * 1999-03-11 2000-09-14 Mount Sinai Hospital Human kallikrein-like genes
WO2001003720A2 (en) * 1999-07-12 2001-01-18 Genentech, Inc. Promotion or inhibition of angiogenesis and cardiovascularization by tumor necrosis factor ligand/receptor homologs
EP1198568B1 (en) * 1999-07-20 2007-07-25 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
IL149849A0 (en) * 1999-12-09 2002-11-10 Sankyo Co A method and kit for testing an agent for treatment of hyperlipemia
US7119165B2 (en) 2000-01-12 2006-10-10 Yale University Nogo receptor-mediated blockade of axonal growth
HK1051543A1 (zh) * 2000-01-12 2003-08-08 Yale University Nogo受体介导的轴突生长封锁
WO2001064856A2 (en) * 2000-02-28 2001-09-07 The Government Of The United States Of America, A S Represented By The Secretary, Department Of Hea Lth And Human Services Regulators of type-1 tumor necrosis factor receptor and other cytokine receptor shedding
EP1283260A4 (en) 2000-04-21 2004-08-18 Takeda Chemical Industries Ltd POLYPEPTIDES OF THE INSULIN / IGF / RELAXIN FAMILY AND THEIR DNA
DE60141409D1 (de) 2000-10-06 2010-04-08 Biogen Idec Inc Homologe des nogo rezeptors
US20020111302A1 (en) * 2000-11-30 2002-08-15 Y. Tom Tang Novel nucleic acids and polypeptides
JPWO2002057448A1 (ja) * 2000-12-27 2004-05-20 第一ファインケミカル株式会社 新規ペプチド及びその活性
WO2002083921A2 (en) 2001-04-10 2002-10-24 Agensys, Inc. Nuleic acids and corresponding proteins useful in the detection and treatment of various cancers
WO2003006687A2 (en) * 2001-07-10 2003-01-23 Medigene Ag Novel target genes for diseases of the heart
NZ533736A (en) * 2001-12-19 2006-09-29 Genentech Inc Compositions and methods for the diagnosis and treatment of tumor and inhibiting cell growth
EP1487268A4 (en) * 2002-03-01 2005-08-24 Blood Ct Res Foundation BAX REDUCER PEPTIDES DERIVED FROM KU-70 AND THEIR USE IN THE PROTECTION OF DAMAGED CELLS
CA2480419A1 (en) * 2002-03-28 2003-10-09 Yamanouchi Pharmaceutical Co., Ltd. Antiopoietin-related growth factor
WO2004002515A1 (ja) * 2002-06-28 2004-01-08 Takeda Chemical Industries, Ltd. 呼吸器疾患の診断・予防・治療剤
ES2346868T3 (es) 2002-08-10 2010-10-21 Yale University Antagonistas de receptor nogo.
WO2005068497A1 (en) * 2004-01-06 2005-07-28 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Iis: a novel ifn-gamma-inducible protein, member of the secretoglobin family, that modulates cellular invasion and migration
WO2007008732A2 (en) 2005-07-07 2007-01-18 Yale University Compositions and methods for suppressing axonal growth inhibition
PE20170441A1 (es) 2014-06-06 2017-04-26 Bristol Myers Squibb Co Anticuerpos contra el receptor del factor de necrosis tumoral inducido por glucocorticoides (gitr) y sus usos
MX2017015260A (es) 2015-06-03 2018-02-19 Squibb Bristol Myers Co Anticuerpos anti receptor de factor de necrosis tumoral inducible por glucocorticoide (gitr) para diagnostico del cancer.
AU2016356780A1 (en) 2015-11-19 2018-06-28 Bristol-Myers Squibb Company Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof
CN110869392A (zh) 2017-05-16 2020-03-06 百时美施贵宝公司 用抗gitr激动性抗体治疗癌症
CN109136275B (zh) * 2017-06-19 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化gitr基因改造动物模型的制备方法及应用
CN114507677B (zh) * 2022-02-16 2023-09-05 中国人民解放军空军军医大学 Ndufs1基因在治疗心梗后心衰中的应用和相关产品
EP4484444A1 (en) * 2023-06-28 2025-01-01 Centre National de la Recherche Scientifique Protein and fragments thereof, and their use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4900673A (en) * 1988-03-28 1990-02-13 President And Fellows Of Harvard College Mutant human angiogenin (angiogenesis factor with superior angiogenin activity) genes therefor and methods of expression
EP0646178A1 (en) 1992-06-04 1995-04-05 The Regents Of The University Of California expression cassette with regularoty regions functional in the mammmlian host
ATE355379T1 (de) * 1994-04-26 2006-03-15 Childrens Medical Center Angiostatin und verfahren zu seiner nutzung zur vermeidung der angiogenese
US5681746A (en) 1994-12-30 1997-10-28 Chiron Viagene, Inc. Retroviral delivery of full length factor VIII
US6337387B1 (en) * 1995-11-17 2002-01-08 Asahi Kasei Kabushiki Kaisha Differentiation-suppressive polypeptide

Also Published As

Publication number Publication date
JP3803681B2 (ja) 2006-08-02
AU1748200A (en) 2000-06-19
AU771751C (en) 2006-04-06
JP2003524385A (ja) 2003-08-19
ATE458050T1 (de) 2010-03-15
WO2000032221A3 (en) 2000-11-23
JP4358159B2 (ja) 2009-11-04
MXPA01005169A (es) 2002-07-02
JP2006006329A (ja) 2006-01-12
AU771751B2 (en) 2004-04-01
EP1135485B1 (en) 2010-02-17
JP3695642B2 (ja) 2005-09-14
KR20010086070A (ko) 2001-09-07
JP2005046146A (ja) 2005-02-24
IL202176A0 (en) 2010-06-16
EP1135485A2 (en) 2001-09-26
CA2347835A1 (en) 2000-06-08
WO2000032221A2 (en) 2000-06-08

Similar Documents

Publication Publication Date Title
KR100529270B1 (ko) 혈관신생 및 심혈관형성의 촉진 또는 억제
KR100499600B1 (ko) 신생 세포 성장을 억제하기 위한 방법 및 조성물
US7164007B2 (en) Anti-PR020044 antibodies
US7115415B2 (en) PRO9821 nucleic acids
US20040043927A1 (en) Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
KR100468978B1 (ko) 분비 및 막횡단 폴리펩티드, 및 이를 코딩하는 핵산
EP1309620A2 (en) Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
CA2416538A1 (en) Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
KR100553300B1 (ko) 혈관신생 및 심혈관형성의 촉진 또는 억제 방법
KR100929057B1 (ko) 신규 Ｓｔｒａ6 폴리펩티드
KR20040088077A (ko) 혈관신생 및 심혈관형성의 촉진 또는 억제
US20020192209A1 (en) Methods and compositions for inhibiting neoplastic cell growth
MXPA01002545A (es) Composiciones y metodos para el tratamiento de tumores.
CA2343006A1 (en) Compositions and methods for the treatment of immune related diseases
KR100448427B1 (ko) 신생 세포 성장을 억제하기 위한 방법 및 조성물
EP2042597A1 (en) Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
AU2003259607B2 (en) Promotion or inhibition of angiogenesis and cardiovascularization
EP1734051A2 (en) Composition and methods for the diagnosis of tumours
EP2077276A1 (en) Compositions and methods for the diagnosis and treatment of disorders involving angiogensis
KR20050053628A (ko) 혈관신생 및 심혈관형성의 촉진 또는 억제 방법
ZA200103707B (en) Promotion or inhibition of angiogenesis and cardio-vascularization.

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20010531

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20020520

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20040524

Patent event code: PE09021S01D

A107 Divisional application of patent
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20040820

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20050910

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20051110

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20051111

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
PR1001 Payment of annual fee

Payment date: 20081024

Start annual number: 4

End annual number: 4

PR1001 Payment of annual fee

Payment date: 20091022

Start annual number: 5

End annual number: 5

PR1001 Payment of annual fee

Payment date: 20101027

Start annual number: 6

End annual number: 6

PR1001 Payment of annual fee

Payment date: 20111020

Start annual number: 7

End annual number: 7

FPAY Annual fee payment

Payment date: 20121019

Year of fee payment: 8

PR1001 Payment of annual fee

Payment date: 20121019

Start annual number: 8

End annual number: 8

FPAY Annual fee payment

Payment date: 20131030

Year of fee payment: 9

PR1001 Payment of annual fee

Payment date: 20131030

Start annual number: 9

End annual number: 9

FPAY Annual fee payment

Payment date: 20141030

Year of fee payment: 10

PR1001 Payment of annual fee

Payment date: 20141030

Start annual number: 10

End annual number: 10

FPAY Annual fee payment

Payment date: 20161028

Year of fee payment: 12

PR1001 Payment of annual fee

Payment date: 20161028

Start annual number: 12

End annual number: 12

FPAY Annual fee payment

Payment date: 20170929

Year of fee payment: 13

PR1001 Payment of annual fee

Payment date: 20170929

Start annual number: 13

End annual number: 13

FPAY Annual fee payment

Payment date: 20180928

Year of fee payment: 14

PR1001 Payment of annual fee

Payment date: 20180928

Start annual number: 14

End annual number: 14

FPAY Annual fee payment

Payment date: 20190924

Year of fee payment: 15

PR1001 Payment of annual fee

Payment date: 20190924

Start annual number: 15

End annual number: 15

PC1801 Expiration of term

Termination date: 20200531

Termination category: Expiration of duration