KR100525474B1 - 항스트레스 및 뇌기능 개선 효과를 가지는 가미사군자탕 함유 의약품 - Google Patents
항스트레스 및 뇌기능 개선 효과를 가지는 가미사군자탕 함유 의약품 Download PDFInfo
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Abstract
Description
구분 | 1일 | 2일 | 3일 | 4일 | 5일 | 6일 |
정상군 | 110.2 ±18.9 | 84.8 ±19.1 | 50.3 ±13.0 | 41.6 ±19.5 | 31.9 ±10.9 | 22.2 ±2.9 |
모의시술군 | 134.1 ±22.4 | 68.7 ±21.0 | 17.6 ±2.9 | 40.5 ±9.6 | 42.3 ±12.8 | 22.1 ±7.3 |
난소절제군 | 115.3 ±24.5 | 73.4 ±11.8 | 38.0 ±9.6 | 23.3 ±6.0 | 29.3 ±3.2 | 22.7 ±4.4 |
+가미사군자탕 | 126.8 ±23.8 | 75.7 ±26.2 | 43.2 ±9.8 | 41.6 ±12.4 | 28.3 ±4.2 | 19.2 ±4.9 |
* 평균 ±표준오차 |
구분 | 학습력 검사/도피에 소요된 시간(초) | ||||||
1일 | 2일 | 3일 | 4일 | 5일 | 6일 | 7일 | |
정상군 | 131.6 ±19 | 91.6 ±12.1 | 56.8 ±11.9 | 54.3 ±15.4 | 32.7 ±9.3* | 27.3 ±7.7 | 14.7 ±4.0* |
뇌손상(사포린) | 155.0 ±8.6 | 117.1 ±21.0 | 102.3 ±28.9 | 93.8 ±22.4 | 77.0 ±25.1# | 54.9 ±25.8 | 54.8 ±27# |
+가미사군자탕 | 123.9 ±41.1 | 100.6 ±7.1 | 71.3 ±35.4 | 67.0 ±35.3 | 48.6 ±23.1 | 41.8 ±19.6 | 34.8 ±11.5 |
*: 뇌손상군에 대한 통계적 유의성(P<0.05) #: 정상군에 대한 통계적 유의성(P<0.05) |
구분 | 기억력검사/플랫폼 영역에서 머무른 정도(%) |
8일 | |
정상군 | 4.0 ±0.9 |
뇌손상(사포린) | 3.6 ±0.6 |
+가미사군자탕 | 3.7 ±1.6 |
구분 | 학습력 검사/도피에 소요된 시간(초) | |||||
1일 | 2일 | 3일 | 4일 | 5일 | 6일 | |
정상군 | 96.3 ±5.9** | 85.6 ±20.6 | 67.8 ±22.5* | 49.8 ±13.5 | 39.3 ±14.1 | 21.2 ±6.3 |
뇌손상(사포린) | 172.0 ±4.2## | 106.8 ±16.0 | 114.7 ±11.1# | 70.2 ±10.1 | 58.7 ±4.7 | 33.7 ±10.3 |
+가미사군자탕 | 145.2 ±11.7## | 91.5 ±14.8 | 53.0 ±15.7* | 38.9 ±5.88* | 26.5 ±5.9* | 27.3 ±4.2 |
*: 뇌손상군에 대한 통계적 유의성(P<0.05) #, ##: 정상군에 대한 통계적 유의성(P<0.05, P<0.01) |
구분 | 기억력검사/플랫폼 영역(2배)에서 머무른 정도(%) |
7일 | |
정상군 | 28.6 ±2.3 |
뇌손상(IBO) | 24.8 ±2.1 |
+가미사군자탕 | 28.1 ±1.2# |
#: 뇌손상군(IBO)에 대한 통계적 유의성(P<0.05) |
구분 | 학습력 검사/도피에 소요된 시간(초) | ||||||
1일 | 2일 | 3일 | 4일 | 5일 | 6일 | 7일 | |
정상군 | 120.9 ±20.0 | 55.7 ±8.2 | 31.7 ±5.1 | 15.3 ±1.6 | 10.2 ±1.7 | 22.9 ±3.4 | 6.4 ±0.9 |
뇌졸중(MCAO) | 152.0 ±8.5 | 117.6 ±18.2* | 73.8 ±24.3 | 53.7 ±11.2* | 45.3 ±15.7 | 59.9 ±17.1 | 34 ±0.8 |
+가미사군자탕 | 118.4 ±13.9 | 70.5 ±17.2# | 58.5 ±15.1 | 45.5 ±14.4 | 75.5 ±19.3 | 46.0 ±19.7 | 5.3 ±2.2 |
#: 뇌졸중군에 대한 통계적 유의성(P<0.05) *: 정상군에 대한 통계적 유의성(P<0.05) |
구분 | 방사형 미로 학습(오선택) | ||||
1일 | 2일 | 3일 | 4일 | 5일 | |
정상군 | 3.07 ±0.44 | 3.87 ±0.37 | 3.27 ±0.73 | 2.40 ±0.29 | 2.40 ±1.3 |
뇌졸중(MCAO) | 3.80 ±0.34 | 5.07 ±0.59 | 5.47 ±0.53 | 6.00 ±0.36** | 5.08 ±1.24 |
+가미사군자탕 | 3.50 ±0.38 | 3.61 ±0.80 | 4.06 ±0.64 | 3.33 ±0.49# | 1.80 ±0.98 |
**: 정상군과의 차이(P<0.01) #: 뇌졸중군과의 차이(P<0.05) |
Claims (9)
- 삭제
- 삭제
- 삭제
- 사군자탕 1 ∼ 10 중량부, 매실 추출물 0.05 ∼ 0.5 중량부, 둥글레 추출물 0.1 ∼ 1 중량부, 갈근 추출물 0.01 ∼ 0.1 중량부 및 계피 추출물 0.1 ∼ 1 중량부가 포함되어 이루어진 가미사군자탕이 함유된 것을 특징으로 하는 뇌기능 개선제.
- 삭제
- 사군자탕 1 ∼ 10 중량부, 매실 추출물 0.05 ∼ 0.5 중량부, 둥글레 추출물 0.1 ∼ 1 중량부, 갈근 추출물 0.01 ∼ 0.1 중량부 및 계피 추출물 0.1 ∼ 1 중량부가 포함되어 이루어진 가미사군자탕이 함유된 것을 특징으로 하는 치매에 의한 학습력 및 기억력 저하 증상 개선제.
- 삭제
- 사군자탕 1 ∼ 10 중량부, 매실 추출물 0.05 ∼ 0.5 중량부, 둥글레 추출물 0.1 ∼ 1 중량부, 갈근 추출물 0.01 ∼ 0.1 중량부 및 계피 추출물 0.1 ∼ 1 중량부가 포함되어 이루어진 가미사군자탕이 함유된 것을 특징으로 하는 뇌졸중에 의한 학습력 및 기억력 저하 증상 개선제.
- 삭제
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Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2012046993A2 (ko) * | 2010-10-04 | 2012-04-12 | 한국한의학연구원 | 오매 추출물을 함유하는 치매 예방 또는 치료용 조성물 |
CN103237556B (zh) * | 2010-10-04 | 2016-03-16 | 韩国韩医学研究院 | 包含乌梅提取物的用于预防或治疗痴呆的组合物 |
KR102070967B1 (ko) * | 2013-12-10 | 2020-01-29 | 한국한의학연구원 | 사군자탕을 유효성분으로 포함하는, 세포의 유도만능줄기세포로의 리프로그래밍 촉진용 조성물 및 이를 이용한 유도만능줄기세포의 제조방법 |
KR101951402B1 (ko) * | 2017-04-18 | 2019-02-22 | 한국한의학연구원 | 뇌 신경세포 보호 활성을 갖는 사군자탕 유산균 발효물 및 이의 용도 |
KR102037944B1 (ko) * | 2018-03-27 | 2019-10-29 | 한국한의학연구원 | 무메푸랄을 포함하는 인지장애 관련 질환의 예방 또는 치료용 조성물 |
KR20230174777A (ko) * | 2022-06-21 | 2023-12-29 | 한국 한의학 연구원 | 육군자탕을 유효성분으로 포함하는 기억력 증진 및 인지기능 장애의 예방, 개선 또는 치료용 조성물 |
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