KR100497944B1 - 성장호르몬 분비촉진용 생약추출물 - Google Patents
성장호르몬 분비촉진용 생약추출물 Download PDFInfo
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- KR100497944B1 KR100497944B1 KR10-2002-0035766A KR20020035766A KR100497944B1 KR 100497944 B1 KR100497944 B1 KR 100497944B1 KR 20020035766 A KR20020035766 A KR 20020035766A KR 100497944 B1 KR100497944 B1 KR 100497944B1
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- Prior art keywords
- growth hormone
- extract
- alcohol
- wolfberry
- goji
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- 208000008128 pulmonary tuberculosis Diseases 0.000 description 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
- 229960004172 pyridoxine hydrochloride Drugs 0.000 description 1
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 description 1
- 239000011764 pyridoxine hydrochloride Substances 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000005471 regulation of growth hormone secretion Effects 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- YXJHJCDOUFKMBG-BMZHGHOISA-M riboflavin sodium Chemical compound [Na+].OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)[N-]C2=O YXJHJCDOUFKMBG-BMZHGHOISA-M 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 235000013580 sausages Nutrition 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 235000011888 snacks Nutrition 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229960000553 somatostatin Drugs 0.000 description 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000008979 vitamin B4 Nutrition 0.000 description 1
- 239000011579 vitamin B4 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 235000008939 whole milk Nutrition 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2300/00—Processes
- A23V2300/14—Extraction
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Botany (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
첨가한 농도 | 성장호르몬 농도 (ng/ml) | |
대조군 | 0 | 23.7 |
비교군* | 300 nM | 38.2 |
500 nM | 57.7 | |
1,000 nM | 146.6 | |
구기자 | 1 ㎎ 약재/ml | 365.2 |
시간(분) | 대조군(ng/ml) | 구기자(ng/ml) | |
0 | 22.144 | 22.779 | 4.364 |
10 | 13.186 | 5.231 | 5.410 |
20 | 12.876 | 4.874 | 5.407 |
30 | 12.523 | 8.568 | 8.712 |
45 | 9.489 | 55.516 | 46.938 |
60 | 8.186 | 6.259 | 8.749 |
90 | 7.492 | 2.760 | 2.801 |
120 | 6.209 | 2.309 | 3.338 |
Claims (7)
- 구기자 추출물을 유효 성분으로 함유하고, 성장 호르몬의 분비를 촉진하여 관절염, 노화, 알츠하이머 질병, 왜소증, 비만, 골다공증 및 궤양으로 이루어진 군으로부터 선택되는 성장호르몬 결핍에 의하여 야기되는 질병을 치료 또는 예방하기 위한 건강 식품.
- 제1항에 있어서, 상기 구기자는 열매(구기자, 拘杞子), 뿌리껍질(지골피, 地骨皮), 잎(구기엽, 拘杞葉)을 포함하는 것을 특징으로 하는 건강 식품.
- 제1항에 있어서, 상기 구기자 추출물이 구기자(Lycii Fructus)에 알콜 또는 알콜과 물의 혼합 용매를 첨가하거나, 산 또는 염기 용액으로 가수분해하고 중화한 후 알콜 또는 알콜과 물의 혼합 용매를 첨가하여 추출되는 것을 특징으로 하는 건강 식품.
- 제3항에 있어서, 상기 알콜 또는 알콜과 물의 혼합 용매는 10 내지 100%의 에틸알콜(ethyl alcohol), 10 내지 100%의 메틸알콜(methyl alcohol) 및 주정으로 구성된 군으로부터 선택되는 것을 특징으로 하는 건강 식품.
- 제3항에 있어서, 상기 산 또는 염기 용액은 0.1 내지 2 N의 농도인 것을 특징으로 하는 건강 식품.
- 삭제
- 삭제
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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KR1020010036531 | 2001-06-26 | ||
KR20010036531 | 2001-06-26 |
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Publication Number | Publication Date |
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KR20030004039A KR20030004039A (ko) | 2003-01-14 |
KR100497944B1 true KR100497944B1 (ko) | 2005-06-29 |
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KR10-2002-0035766A KR100497944B1 (ko) | 2001-06-26 | 2002-06-25 | 성장호르몬 분비촉진용 생약추출물 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101326478B1 (ko) | 2011-06-10 | 2013-11-08 | 인타글리오주식회사 | 삼정환 발효물을 함유한 슬리밍용 화장료 조성물 및 그 제조방법 |
KR101524230B1 (ko) * | 2013-08-05 | 2015-05-29 | 동우당제약(주) | 지골피 에탄올 추출물을 함유하는 골대사 질환 예방 및 골 기능 개선을 위한 조성물 |
KR102517826B1 (ko) | 2022-07-22 | 2023-04-05 | 주식회사 상상바이오 | 기호도가 우수한 성장기 어린이의 건강 및 발육 개선용 조성물의 제조방법 |
-
2002
- 2002-06-25 KR KR10-2002-0035766A patent/KR100497944B1/ko active IP Right Grant
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101326478B1 (ko) | 2011-06-10 | 2013-11-08 | 인타글리오주식회사 | 삼정환 발효물을 함유한 슬리밍용 화장료 조성물 및 그 제조방법 |
KR101524230B1 (ko) * | 2013-08-05 | 2015-05-29 | 동우당제약(주) | 지골피 에탄올 추출물을 함유하는 골대사 질환 예방 및 골 기능 개선을 위한 조성물 |
KR102517826B1 (ko) | 2022-07-22 | 2023-04-05 | 주식회사 상상바이오 | 기호도가 우수한 성장기 어린이의 건강 및 발육 개선용 조성물의 제조방법 |
Also Published As
Publication number | Publication date |
---|---|
KR20030004039A (ko) | 2003-01-14 |
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