KR100456831B1 - 메타아르세나이트을 함유한 항암제 조성물 - Google Patents
메타아르세나이트을 함유한 항암제 조성물 Download PDFInfo
- Publication number
- KR100456831B1 KR100456831B1 KR10-2002-0022737A KR20020022737A KR100456831B1 KR 100456831 B1 KR100456831 B1 KR 100456831B1 KR 20020022737 A KR20020022737 A KR 20020022737A KR 100456831 B1 KR100456831 B1 KR 100456831B1
- Authority
- KR
- South Korea
- Prior art keywords
- salt
- arsenic
- meta
- arsenite
- sodium
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/36—Arsenic; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
종양세포주 | 아르세닉산나트륨 염 농도(㎍/㎖)별 T/C(%) | ||||
1 | 3 | 10 | 30 | 100 | |
HT29 | 97 | 100 | 104 | 104 | 99 |
CCRF-CEM | 104 | - | 38 | - | 13 |
K562 | 162 | 125 | 145 | 27 | 7 |
U937 | 103 | 75 | 9 | 9 | 10 |
LXFL 529L | 98 | 93 | 106 | 101 | 77 |
MEXF 462L | 108 | 100 | 98 | 44 | 1 |
MEXF 514L | 107 | 97 | 93 | 74 | 8 |
RXF 944L | 131 | 111 | 94 | 80 | 20 |
UXF 1138 | 93 | 97 | 99 | 78 | 11 |
- : 실험하지 않음. |
종양세포주 | 약물농도(㎍/㎖)별 T/C(%) | ||||
1 | 3 | 10 | 30 | 100 | |
HT29 | 91 | 60 | 40 | 22 | 14 |
CCRF-CEM | 48 | - | 43 | - | 29 |
K562 | 51 | 15 | 15 | 18 | 13 |
U937 | 3 | 3 | 2 | 2 | 1 |
LXFL 529L | 79 | 61 | 21 | 7 | 4 |
MEXF 462L | 112 | 120 | 101 | 91 | 15 |
MEXF 514L | 120 | 95 | 98 | 70 | 21 |
RXF 944L | 124 | 79 | 57 | 32 | 9 |
UXF 1138 | 107 | 114 | 103 | 95 | 30 |
- : 실험하지 않음. |
종양 세포주 | IC70(㎍/㎖) |
DLD1 | 0.48 |
GXF251L | 3.08 |
MXAF401NL | 0.32 |
OVCAR3 | 3.02 |
PC3 | 0.85 |
RXF486L | 0.63 |
Claims (1)
- 메타아르세나이트 염을 유효성분으로 함유하는 것을 특징으로 하는 항암제 조성물.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020010023219 | 2001-04-28 | ||
KR200123219 | 2001-04-28 | ||
KR1020010023219A KR20020083678A (ko) | 2001-04-28 | 2001-04-28 | 아르세닉산나트륨 염, 소디움 메타아르세나이트 또는 이의혼합물을 함유한 항암제 조성물 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20020083458A KR20020083458A (ko) | 2002-11-02 |
KR100456831B1 true KR100456831B1 (ko) | 2004-11-10 |
Family
ID=27703007
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020010023219A KR20020083678A (ko) | 2001-04-28 | 2001-04-28 | 아르세닉산나트륨 염, 소디움 메타아르세나이트 또는 이의혼합물을 함유한 항암제 조성물 |
KR10-2002-0022737A KR100456831B1 (ko) | 2001-04-28 | 2002-04-25 | 메타아르세나이트을 함유한 항암제 조성물 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020010023219A KR20020083678A (ko) | 2001-04-28 | 2001-04-28 | 아르세닉산나트륨 염, 소디움 메타아르세나이트 또는 이의혼합물을 함유한 항암제 조성물 |
Country Status (1)
Country | Link |
---|---|
KR (2) | KR20020083678A (ko) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101413731B1 (ko) * | 2005-05-09 | 2014-07-10 | 코미녹스 인코포레이티드 | 비뇨 생식기암 및 이의 전이 치료용 비소산, 이것의나트륨염 및 이것의 유도체를 함유하는 약학 조성물 |
WO2022035146A1 (ko) * | 2020-08-12 | 2022-02-17 | 이상봉 | 탈모방지 또는 발모촉진용 외용제 조성물 |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20030075017A (ko) * | 2002-03-15 | 2003-09-22 | 한국원자력연구소 | 삼산화비소를 포함하는 혈관신생억제제 |
WO2006024489A2 (en) * | 2004-08-30 | 2006-03-09 | Interstitial Therapeutics | Methods and compositions for the treatment of cell proliferation |
WO2006104292A1 (en) * | 2005-03-31 | 2006-10-05 | Komipharm International Co., Ltd. | Pharmaceutical composition comprising arsenic acid, meta-arsenite, and pharmaceutically acceptable salts |
US8945505B2 (en) * | 2007-02-02 | 2015-02-03 | Panaphix, Inc. | Use of arsenic compounds for treatment of pain and inflammation |
US20090246291A1 (en) * | 2008-03-27 | 2009-10-01 | Angelika Burger | Method and compositions for treatment of cancer |
IN2012DN02195A (ko) * | 2009-09-18 | 2015-08-21 | Kominox Inc | |
KR101309844B1 (ko) * | 2013-03-15 | 2013-09-23 | 박상채 | 항암 활성 증진용 한약재 및 이의 제조방법 |
BR112020019425A2 (pt) * | 2018-03-22 | 2020-12-29 | Komipharm International Australia Pty Ltd | Composição farmacêutica compreendendo meta-arsenito e método de fabricação |
KR20220020637A (ko) * | 2020-08-12 | 2022-02-21 | 이상봉 | 항암화학요법이나 방사선요법으로 인한 암 환자의 탈모증을 포함한 탈모증 환자에 대하여 탈모를 방지하고 발모를 촉진하는 메타아르세나이트의 염을 함유하는 경구 투여용 약학적 조성물 |
KR20220020633A (ko) * | 2020-08-12 | 2022-02-21 | 이상봉 | 탈모방지 또는 발모촉진용 주사제 조성물 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0687761A (ja) * | 1992-08-05 | 1994-03-29 | Jane Palen Catherine | 腫瘍治療薬 |
KR970073600A (ko) * | 1996-05-20 | 1997-12-10 | 배일주 | 항종양 활성을 가지는 항암제 추출 조성물 및 그 추출 방법 |
WO1999024029A1 (en) * | 1997-11-10 | 1999-05-20 | Memorial Sloan-Kettering Cancer Center | Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol |
-
2001
- 2001-04-28 KR KR1020010023219A patent/KR20020083678A/ko unknown
-
2002
- 2002-04-25 KR KR10-2002-0022737A patent/KR100456831B1/ko active IP Right Review Request
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0687761A (ja) * | 1992-08-05 | 1994-03-29 | Jane Palen Catherine | 腫瘍治療薬 |
KR970073600A (ko) * | 1996-05-20 | 1997-12-10 | 배일주 | 항종양 활성을 가지는 항암제 추출 조성물 및 그 추출 방법 |
WO1999024029A1 (en) * | 1997-11-10 | 1999-05-20 | Memorial Sloan-Kettering Cancer Center | Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol |
Non-Patent Citations (2)
Title |
---|
Cancer Research, 59, pp.1041-8, 1999 * |
Cancer Research, Philippe Rousselot et al., 1999, 59, p1041-1048 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101413731B1 (ko) * | 2005-05-09 | 2014-07-10 | 코미녹스 인코포레이티드 | 비뇨 생식기암 및 이의 전이 치료용 비소산, 이것의나트륨염 및 이것의 유도체를 함유하는 약학 조성물 |
WO2022035146A1 (ko) * | 2020-08-12 | 2022-02-17 | 이상봉 | 탈모방지 또는 발모촉진용 외용제 조성물 |
Also Published As
Publication number | Publication date |
---|---|
KR20020083678A (ko) | 2002-11-04 |
KR20020083458A (ko) | 2002-11-02 |
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