KR100432377B1 - Cosmetic composition containing pumpkin extracts - Google Patents

Abstract

The present invention relates to a cosmetic composition comprising a pumpkin extract.

Specifically, the cosmetic composition of the present invention comprises a pumpkin extract in an amount of 0.0001 to 10.0% by weight based on the total weight of the cosmetic composition, excellent effect on the prevention and improvement of edema including idiopathic edema of the face and body caused by stress or overwork Indicates.

Cosmetic composition comprising a pumpkin extract of the present invention may be prepared as a base cosmetic for preventing and improving edema, such as supple cosmetics, nourishing cosmetics, massage cream, essence, pack.

Description

Cosmetic composition containing pumpkin extracts {Cosmetic composition containing pumpkin extracts}

The present invention relates to a cosmetic composition comprising the pumpkin extract as an active ingredient.

Zucchini (Pumpkin, Cucurbitaceae) is a yearly family belonging to the family, and its origin is South America, which is cultivated in many parts of the world.In our country, C. moschata is native to tropical America in southern Mexico, C. maxima), and three species of C. pepo, native to northern Mexico and North America.

Pumpkin in Korea has been traditionally introduced as a good food for people with weak stomach, recovery patients, postpartum edema, and is effective in hypertension, diabetes, neuralgia, women's diseases, postpartum care, fragile patients and aging prevention. Known.

Pumpkin contains carbohydrates, proteins, fats, sugars, ash, fiber, calcium, vitamins, and the like, and in particular, it contains provitamin A and carotene, which are vitamin A in the human body. In addition, the unique scent of pumpkin is composed of unsaturated fatty acids, which not only have an excellent effect on the prevention of adult diseases, but also contain the essential amino acid lecithin to improve the brain (public number 1997-0032486).

In the old pumpkin, a large amount of carotenoid compounds, which are yellow, are natural pigments used as additives for various processed foods. Such carotenoid pigments include pigment components such as carotene, lycopene, and lutein. According to the composition of carotenoids, the pigment of amber is mainly composed of β-carotene and α-carotene and occupies 67 to 96% of the total carotenoid content.

In particular, β-carotene showing the effect of vitamin A has been reported to have a variety of pharmacological effects. There is a great deal of interest in research reports that carotene, which was thought to be a precursor of vitamin A, prevents cancer. That is, among the many carotenoids present in nature, only 10% of the carotenoids having the activity of vitamin A have been shown that the anticancer effect of the carotenoids is not the function of the precursor of vitamin A. Scholars say it is related to other functions.

As the pumpkin is mature, carotene and other nutrients increase, so as not only the value as a food, but also recently as the physiological action of various components of the pumpkin has been spotlighted as a health food.

As such, pumpkin has been used as a material of herbal medicine or pumpkin soup because of its rich nutritional value, unique fragrance, and unique taste. . However, the use of pumpkin as a dietary supplement has been reported a lot, but the edema effect of the cosmetic using it has not been reported.

Edema occurs when there are abnormalities in the kidney, such as acute nephritis, nephrotic syndrome, and kidney failure. Edema may also occur in cases of heart failure, in which the heart cannot deliver blood properly, or cirrhosis of the liver, which hardens and hardens. In oriental medicine, edema occurs because the body's organs are not metabolized smoothly.

However, edema can occur even if there is no abnormality, which is called idiopathic edema. This often occurs with mental stress, irregularities in the amount and time of meals, or frequent use of diuretics or constipation.

Edema is known to promote blood circulation disorders and skin aging due to local excess moisture in the skin. In general, skin problems are known to exacerbate the condition of people with lymphedema with inadequate functioning and overload of the lymphatic system.

At the end of the 18th century, Winiwarter suggested conservative therapies for edema, which consisted of meticulous skin cleansing, bed rest, compression bandages, massage and therapeutic exercises (Foldi et al., 1989). However, physiotherapy for complex edema that is currently used most often in the treatment of edema patients consists of first, meticulous skin care, second, lymphatic absorption massage, third, compression bandage and fourth, therapeutic exercise.

Skin care for edema patients is very important, but there are few places where this is well explained. In particular, there have been no reports of improving or preventing idiopathic edema other than diet, proper exercise, and muscle relaxation gymnastics.

The present inventors separated the natural products from 100 kinds of domestic native plants in order to develop a substance having an effect of preventing and improving edema, and found that the pumpkin extract shows excellent efficacy and developed a cosmetic using the same. To prevent aging.

It is an object of the present invention to provide a cosmetic composition comprising a pumpkin extract excellent in improving and preventing idiopathic edema of the face and body caused by stress or overwork.

The present invention relates to a cosmetic composition comprising a pumpkin extract.

Specifically, the cosmetic composition of the present invention comprises 0.0001 to 10.0% by weight, preferably 0.0005 to 10.0% by weight, and more preferably 0.005 to 5.0% by weight of the pumpkin extract relative to the total weight of the cosmetic. If the amount of use is less than 0.0001% by weight, no obvious effect can be expected. If the amount is more than 10.0% by weight, no apparent effect is increased by increasing the amount of inclusion.

Pumpkin extract exhibits anti-edema effect and inhibitory effect on edema formation by removing salt by ion channel of local salt.

Pumpkin extract of the present invention is 1 to 10 times the weight of the dry weight of the pumpkin, anhydrous or hydrous lower alcohol of 1 to 4 carbon atoms, or a mixed solvent of these lower alcohol and water, acetone, ethyl acetate, chloroform or 1 The mixture was extracted with 3,3-butylene glycol, and the extract was distilled under reduced pressure, followed by freeze drying or spray drying.

Pumpkin extract in the present invention can be added to the basic cosmetics, such as softening cosmetics, nutrient cosmetics, massage creams, essences, packs according to a conventional method can be prepared as a cosmetic for preventing and improving edema.

Examples and Experimental Examples below describe the contents of the present invention, but the present invention is not limited thereto.

Example 1.

Purchasing a commercially available pumpkin, washing with purified water, drying, 200 g of the pulverized crushed powder into 2.5 L of 80% ethanol solution, boiled for 4 hours in a reflux extractor with a cooling capacitor, and filtered with a 300 mesh filter cloth , The residue was extracted once more in the same way. Each extract was combined, filtered through Whatman No. 5 filter paper, and the solvent was removed using a vacuum condenser and lyophilized to obtain a dry weight of 24.5 g.

Example 2.

200 g of a pulverized product obtained by purchasing a commercially available pumpkin was put in 2.5 L of 80% methanol, and the same method as in Example 1 was carried out to obtain a dry weight of 25.3 g.

Example 3.

200 g of a pulverized product obtained by purchasing a commercially available pumpkin was put in 2.5 L of purified water, and the same method as in Example 1 was carried out to obtain a dry weight of 24.8 g.

Example 4.

200 g of a pulverized product obtained by purchasing a commercially available pumpkin was put in 2.5 L of 80% acetone, and the same method as in Example 1 was carried out to obtain a dry weight of 21.3 g.

Example 5.

200 g of a pulverized product obtained by purchasing a commercially available pumpkin was put in 2.5 L of n-butanol solution, and the same method as in Example 1 was carried out to obtain a dry weight of 25.7 g.

Example 6.

200 g of a pulverized product obtained by purchasing a commercially available pumpkin was put in 2.5 L of an ethyl acetate solution, and the same method as in Example 1 was carried out to obtain a dry weight of 24.2 g.

Example 7.

200 g of a pulverized product obtained by purchasing a commercially available pumpkin was put in 2.5 L of a 1,3-butylene glycol solution, and the same method as in Example 1 was carried out to obtain a dry weight of 23.7 g.

Example 8.

200 g of a pulverized product obtained by purchasing a commercially available pumpkin was put in 2.5 L of a chloroform solution, and the same method as in Example 1 was carried out to obtain a dry weight of 21.5 g.

Prescription example 1 .

Prescription example of the softening longevity (skin) of the cosmetic containing the pumpkin extract in Example 1 of the present invention is as follows.

ingredient Content (% by weight) Pumpkin Extract 0.2 1,3-butylene glycol 6.0 glycerin 4.0 Oleyl alcohol 1.2 Polysorbate 20 3.0 ethanol 5.0 Propylparaben 0.1 Benzophenone-9 2.0 Carboxy Vinyl Polymer 1.0 Pf. 962 0.2 Purified water Remaining amount system 100

Prescription example 2 .

Prescription example of milk lotion in the cosmetic composition containing the extract of Example 2 is as follows.

ingredient Content (% by weight) Pumpkin Extract 0.2 Propylene glycol 6.0 glycerin 4.0 Triethanolamine 1.2 Tocopheryl Acetate 3.0 Liquid paraffin 5.0 Squalane 3.0 Macadamia Nut Oil 2.0 Polysorbate 60 1.5 Sorbitan sesquioleate 1.0 Propylparaben 0.1 Carboxy Vinyl Polymer 1.0 Pf.Kn-921 0.3 Purified water Remaining amount system 100

Prescription example 3 .

Prescription example of nutrition cream in the cosmetic composition containing the extract of Example 4 is as follows.

ingredient Content (% by weight) Pumpkin Extract 0.2 vaseline 7.0 glycerin 4.0 Triethanolamine 0.5 Tocopheryl Acetate 0.1 Liquid paraffin 10.0 Squalane 3.0 Beeswax 2.0 Polysorbate 60 2.0 Sorbitan sesquioleate 2.5 Propylparaben 0.05 Carboxy Vinyl Polymer 1.0 Pf.Kn 942 0.2 Purified water Remaining amount system 100

Prescription example 4 .

Prescription example of a massage cream in a cosmetic containing an extract of Example 1 of the present invention is as follows.

ingredient Content (% by weight) Pumpkin Extract 0.3 Propylene glycol 6.0 glycerin 4.0 Triethanolamine 0.5 Tocopheryl Acetate 0.1 Liquid paraffin 30.0 Cetearyl Alcohol 2.0 Beeswax 2.0 Polysorbate 60 2.1 Sorbitan sesquioleate 2.5 Propylparaben 0.1 Carboxy Vinyl Polymer 1.0 Pf. 951 0.2 Purified water Remaining amount system 100

Experimental Example 1 . Edema inhibition and prevention effect evaluation

The edema inhibition and prevention effect of the cosmetics in the present invention was evaluated through a practical use test. Comparative experiment was performed using the cream of Formulation Example 3 and the cream containing no extract of the present invention as a comparative example.

80 females with idiopathic edema who were 30-40 years old were randomly divided into two groups. Prescription 3 and comparative creams were applied twice a day every morning and then the right amount of cream was applied to the face and hands and feet for 2 months in a row. . The improvement effect of edema was evaluated by observing the improvement of facial and limbs after one month and at the end of the actual test.

The experimental results are shown in the table below.

After 1 month Very effective available Slightly effective invalidity Effectiveness Prescription Example 3 One 16 11 12 38.33 Comparative example 0 2 3 35 5.83

After 2 months Very effective available Slightly effective invalidity Effectiveness Prescription Example 3 4 15 14 7 46.66 Comparative example 0 2 4 34 6.66

Very Valid = 3, Valid = 2, Slightly Valid = 1, Invalid = 0

Effective after 1 month

Prescription Example 3: [(3 * 1 + 2 * 16 + 1 * 11 + 0 * 8) / (3 * 40)] * 100 = 38.33%

Comparative Example: [(2 * 2 + 1 * 3) / (3 * 40)] * 100 = 5.83%

Effective after two months

Prescription Example 3: [(3 * 4 + 2 * 15 + 1 * 14 + 0 * 5) / (3 * 40)] * 100 = 46.66%

Comparative Example: [(2 * 2 + 1 * 4) / (3 * 40)] * 100 = 6.66%

As a result of the above experiment, the cosmetic composition containing the extract of the present invention showed an excellent edema improvement effect compared to the comparative example. In addition, no skin irritation or the like appeared at the site where the present invention was applied.

The cosmetic composition comprising the pumpkin extract of the present invention shows an excellent effect on the prevention and improvement of edema of the skin.

Claims (7)

Cosmetic composition for edema improvement and prevention comprising a pumpkin extract. According to claim 1, Pumpkin extract is a cosmetic composition for improving and preventing edema, characterized in that it comprises 0.0001 ~ 10.0% by weight relative to the total weight of the cosmetic. According to claim 1, Pumpkin extract is a cosmetic composition for improving and preventing edema, characterized in that it comprises 0.0005 ~ 10.0% by weight relative to the total weight of the cosmetic. According to claim 1, Pumpkin extract is a cosmetic composition for edema improvement and prevention, characterized in that it comprises 0.005 to 5.0% by weight relative to the total weight of the cosmetic. The method of claim 1, wherein the pumpkin extract is 1 to 10 times the weight of the dry weight of the pumpkin, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, or a mixed solvent of these lower alcohol and water, acetone, ethyl acetate, Extraction with chloroform or 1,3-butylene glycol, the extract is distilled under reduced pressure and lyophilized or spray dried, characterized in that the cosmetic composition for edema improvement and prevention. According to claim 1, Pumpkin extract is a cosmetic composition for improving and preventing edema, characterized in that added to the basic cosmetics selected from the soft cosmetics, nutrients, massage creams, essences, packs and the like. delete