KR100364390B1 - Compositions for the treatment of diabetes - Google Patents

Abstract

The present invention relates to a composition for treating diabetes. Specifically, the present invention relates to a composition for treating diabetes, including gastric hair, fruit tree, phalanx, corn beard, sweet ginseng, baekrye, turmeric, bokryeong, taeksa, earth and sand, and short skin.

The composition of the present invention has the effect of preventing diabetes, preventing complications and treating them, in particular, hepatic dementia (肝 腎陰虛 症), stomach ulcer (胃 陰虛), lung (肺), heart (heart), cough (氣陰 虛症) The present invention relates to a herbal composition which has an excellent effect on), is particularly effective against insulin-independent diabetes (type 2 diabetes), and is quite effective against insulin-dependent diabetes (type 1 diabetes).

Description

Compositions for the treatment of diabetes

The present invention relates to a composition for treating diabetes. Specifically, the present invention relates to a composition for treating diabetes, including gastric hair, fruit tree, phalanx, corn beard, sweet ginseng, baekrye, turmeric, bokryeong, taeksa, earth and sand, and short skin.

Diabetes mellitus is a non-infectious chronic disease, in which the insulin secreted from the pancreatic β cells is insufficient or does not function properly, so glucose is not used as an energy source in the body and remains high in blood and excreted in the urine.

Diabetes is largely divided into insulin dependent diabetes mellitus (IDDM) and non-insulin dependent diabetes mellitus (NIDDM). Can be classified.

Type 1 diabetes is a condition in which pancreatic β-cells are depleted due to genetic causes, viral infections, etc., and thus little insulin is secreted. It occurs suddenly in the tens to twenties, and is also called juvenile diabetes.

Type 2 diabetes is caused by family history, obesity, stress, eating errors or drugs that antagonize with insulin, etc., which appears well after the age of 40, and is also called adult diabetes. Insulin secretion is sufficient in the pancreas, but blood glucose is not normalized despite hyperinsulinemia due to differences in insulin resistance and glucose utilization from normal individuals.

In Korea, more than 95% of diabetics are type 2 diabetics.

In oriental medicine, diabetes is classified into three types: Yin-Yu, Yin-Yin and Yin-Yang.

Negative diabetes is mostly early diabetes, also called acute diabetes, and its symptoms are different depending on the size of organs. In particular, "sickness," "wimme," and "moan." It causes symptoms such as "acute lung pain", "heart pain", "unchallenged", "gihe", and "blood scar". . That is, thirst, fever, urination, bleeding, and blood sugar are high.

Acute diabetes mellitus occurs in diabetic patients 10 years or older with chronic diabetes. It occurs when both Qi and Yin are in vain at the same time, the sugar level is not high, the limb is drowsy, and there is no strength.

Yin-Yang-Yang Diabetes is senile diabetes, mainly in terminal patients.

The main cause of diabetes is the effect of insulin receptor binding. The human body itself has "specific immune function" and "non-specific immune function". Many years of clinical trials have shown that when the non-specific immunity rises, insulin receptor binding capacity is lowered and blood glucose is increased. In oriental medicine, the water-binding force and spleen function are in common with each other, and Gulf, Giheum, Bloodshed, Disposal, Eum-Hee, Moo-Hee-Hu directly affects the spleen function and decreases the water-binding ability.

Diabetes, also known as incurable, can be cured if detected early. Early treatment can prevent complications.

Early detection of diabetes is finding a glucose intolerance. Glucose intolerance is an intermediate stage between normal and diabetic patients, before the onset of diabetes. In other words, the ability of the pancreatic beta cells to control blood sugar and secrete insulin is reduced or insulin resistance is reduced, and thus the ability to transport glucose to cells is reduced.

Complications develop later in diabetes treatment, usually due to acute complications (diabetic ketoacidosis, hyperosmotic biketogenic coma, lactic acidosis) and chronic complications (diabetic retinopathy, diabetic nephropathy, diabetic neuropathy). Overall metabolic and sensory functions are reduced.

In order to treat these diabetes and complications with herbal medicines, components were extracted from Euonymus alata. Arrow tree is also known as Yumo (귀), ear jeon (鬼 箭 羽), Shinjeonmok (神箭 木).

Stomach hair has been used as a folk medicine that has no known cause, postpartum blood pill, mental anxiety, women's uterine bleeding, treatment, and blood loss. In addition, it improves blood circulation, releases blood, removes inflammation and stabilizes the mind, and is known to be effective in various cancers such as gastric cancer and esophageal cancer.

Recently, in addition to such action, the hypoglycemic action of oxaloacetic acid contained in the entire stomach is known, and research as a therapeutic agent for diabetes is being conducted.

The treatment of diabetes in the stomach is thought to be due to the oxaloacetic acid present in the stomach, which promotes the release of β cells from the pancreatic Langerhan's islet. In addition, by lowering the cholesterol level by the shedding action of Friedelin (Friedelin) present in the stomach can indirectly exhibit a therapeutic effect of diabetes. However, the septic action caused by Friedellin is too sharp and strong, causing stomach pain in the stomach, and the intestines have the effect of dissolving, so it is not possible to take a single ingredient.

The present invention is a combination of the fruit tree, golgol, corn beard, sweet ginseng, baekchul, turmeric, Bokryeong, Taeksa, Tosa, short skin to relieve the toxicity of the stomach, while showing a novel therapeutic effect on the negative diabetes mellitus type 2 diabetes It is to provide a herbal composition.

The present invention relates to a herbal composition useful for treating diabetes. Specifically, the present invention relates to a herbal composition for treating diabetes, including gastric hair, fruit tree, phalanx, corn beard, sweet ginseng, baekrye, turmeric, bokyeong, taeksa, earth and sand, and short skin.

As described above, by combining various herbal ingredients with the oxaloacetic acid component of the stomach, it is possible to prevent side effects due to the use of the stomach alone as well as to treat all the various symptoms that can be caused by diabetes. Can be.

Hereinafter, it will be described in detail how the effect of each herbal ingredient in the composition of the present invention to treat diabetes.

Stomach (衛 矛) to write and sputum acts and bleeding. Friedelin in the stomach lowers cholesterol by blood clotting, and oxaloacetic acid lowers blood sugar and urine glucose and increases weight.

Overgrowth cools the stomach, regulates heat, detoxifies, and suppresses thirst.

Phalanges (地骨皮) is to treat the weak body and fever and cold sweat, cool the fever and blood, and lowers sugar.

Corn beard (玉米 須) regulates moisture, releases heat, calms the liver, regulates the gallbladder, and lowers sugar.

Danshen (丹 參) helps blood circulation and nerve stabilization, discharges purulent and suppresses pain.

Take these five medicines together to control and detox your fever, to treat your fragile body, fever and cold sweats, and to strengthen the sugar-lowering function of your stomach.

Baekchul (白 朮) is a fat, humidity control (燥濕) to control and neutralize.

Turmeric warms the spleen, neutralizes, calms the liver, and detoxifies.

Ginseng (人 參) secretion of saliva and blood work, energizes, anti-toxic, detoxification.

Bokryeong stabilizes the mind and body and regulates urine.

Taeksa (澤瀉) to regulate the urine, the nerve stability and detoxification.

Tosa (兎 絲 子) is to control the yin and yang, to show the height and brighten the eyes.

Short skin (丹皮) lowers the heat, and controls the weakness.

If you take these seven herbs together, you will feel energetic and detoxify, regulate moisture, stabilize your nerves, even out yin and yang, and protect your liver and kidneys.

As described above, in the composition of the present invention, the action of each herbal ingredient appears in combination, and thus, the herbal ingredients used are formulated by relativity such as heat of fever, cold, and reading. It performs a function that harmonizes. In addition, saliva secretion suppresses thirst, reinforces the group and lowers heat, lowers sugar and protects the liver and kidneys.

In the composition of the present invention, each of the main herbal ingredients is based on the weight of stomach hair: fruit fruit: phalanx skin: corn mustard: salvia: white extract: turmeric: Fuling: Taeksa: earthenware: skin: 30: 10: 10: 10: 5: 5: The weight ratio of 5: 7: 5: 5: 3 is used. Such a composition ratio is found in consideration of the effective dose and side effects of each herbal ingredient, and if it is out of the range of the ratio, there is a possibility that the effect is drastically reduced or side effects.

The preparation method of the composition according to the present invention is as follows.

The stomach is washed thoroughly, immersed in distilled water, the aqueous solution is adjusted to ph 9 with sodium hydroxide, and then filtered by decoction for 3 hours under reduced pressure, the filtrate is concentrated to make a precipitate, dried under vacuum, and then pulverized. Sieve to powder.

Corn salts are washed and fermented at 50 ℃ (added with yeast), then the blemishes are screened and 5 times distilled water is added, and the mixture is filtered for 3 hours under reduced pressure, concentrated to dryness, pulverized and sieved at least 100 times. Powder it.

Ginseng is washed, dried and ground, sieved more than 100 times, and powdered. Salvia ginseng is extracted with 70% ethanol, concentrated under reduced pressure, dried in vacuo, pulverized and sieved at least 100 times to obtain a powder state.

Turmeric, Baekchul, Jigolpi, Bokryeong, Danpi, Taeksa, Tosa were added 5 times distilled water in total, 3 hours under reduced pressure, concentrated under reduced pressure and dried under vacuum to sieve 100 times to make powder. The fruit is washed, frozen and extracted, and the filtrate is concentrated to obtain a liquid. This is called an address.

When the above components in powder form are mixed and sieved at least 100 times, the mixed component powder is mixed with the filter concentrate and dried in vacuo to obtain the desired composition of the present invention.

In addition to the composition, if necessary, components such as pollen, bokbunja, sagejiku, licorice, schisandra, cheongung, ganoderma lucidum, astragalus, pulsation, jade porridge, and caustic may be optionally added.

The composition of the present invention may be formulated into oral preparations, such as pills, tablets, capsules, solutions, suspensions, and the like, according to conventional methods in the pharmaceutical field when used clinically for the treatment of diabetes. Can be used.

The dosage of the composition of the present invention for the treatment of diabetes mellitus may be appropriately selected depending on the sex, age, health condition, type of diabetes mellitus to be treated, severity, complications, etc., but is generally 1 day for an adult (weight about 50 kg). The capacity is 3 to 8 g, preferably 4 to 5 g.

In addition, since the composition of the present invention is not toxic in a large amount, it can be used as a health food for lowering blood sugar. When used as a food, the powder consisting of the composition is prepared and used according to the conventional food and beverage manufacturing method.

The present invention is described in more detail by the following examples and experimental examples, but the present invention is not limited thereto.

Example 1

After washing and drying 300g of the stomach hair, immersed in distilled water, and the aqueous solution was adjusted to ph 9 with sodium hydroxide, and then filtered under reduced pressure for 3 hours, filtered and the filtrate was concentrated to make a precipitate, dried under vacuum, and then pulverized 100 Sieve at least twice to form powder (1). 100 g of corn salt was washed and fermented at 50 ° C. (added with yeast), then the blemishes were removed, 5 times distilled water was added, and the mixture was filtered for 3 hours under reduced pressure, concentrated to dryness, and pulverized. To form powder (2). Wash 50g of ginseng, dry it, grind it and sift it over 100 times to make it powder (3). After extracting 50g of salvia using 70% ethanol, concentrated under reduced pressure, dried in vacuo, pulverized and sieved 100 times to make a powder (4). Turmeric, Baekchul, Jigolpi, Bokryeong, Danpi, Taeksa, Tosa are combined with 5 times distilled water, and then depressurized for 3 hours, concentrated under reduced pressure, and dried under vacuum to sieve 100 times to form a powder (5).

After washing 100 g of confectionery and freezing, the filtrate is concentrated to obtain a liquid (6). The obtained (1) (2) (3) (4) (5) is mixed and sieved at least 100 times, (6) is mixed with the solution and dried in vacuo.

The composition ratio of the final herbal composition is as follows. Stomach (30%), ginseng (5%), turmeric (5%), fruit (10%), corn salt (10%), sweet ginseng (5%), baekchul (5%), phalanges (10%) (7%), short skin (3%), talc (5%), and earth and sand (5%).

Experimental Example 1

<Glucose lowering effect of the composition of the present invention on normal mice>

40 rats weighing 20 ± 2 g are divided into 4 groups of 10 rats per 1 group. For normal tanks without drug, an equivalent amount of physiological saline is administered to the abdominal cavity, and the drug tank is administered with glycenclamide (Glibenclamide) 5 mg / kg was administered, and 2 g / kg and 1 g / kg of the composition of the present invention were administered to the intraperitoneal rats, respectively. All were administered for 15 days. Before administration and 15 days after administration, approximately 0.05 ml of blood was collected from the rat tail and the fasting blood glucose level was measured using a US JD2DGA7CC microglucometer. The measured results are shown in Table 1.

Effect of the Composition of the Invention on Blood Glucose in Normal Rats (× ± SD) Group stars Number of animals (n) Preparation amount (g / kg) Blood glucose level (mmol / L) Before dosing 15 days after dosing Normal tank (physiological saline) 10 - 8.20 ± 1.24 8.23 ± 1.14 Drug group (glybenclamide) 10 0.005 8.18 ± 1.03 7.04 ± 1.02 * (14.5) Composition dosing tank of the present invention 10 2 8.22 ± 1.12 7.06 ± 1.04 * (14.2) 10 One 8.25 ± 1.16 7.26 ± 1.06 * (11.8)

※ mmol / L → mg / dl: × 17.90

※ Comparison with normal: * P <0.05

As can be seen from the results described in Table 1, the composition of the present invention exhibits a hypoglycemic effect in normal pups as well as glybenclamide, which has already been proven to be effective as an antidiabetic agent.

Experimental Example 2

Hypoglycemic Effect of the Composition of the Present Invention on Alloxone-Induced Diabetic Rats

Male and female rats weighing 20 ± 2 g were tested together. Fasting for 12 hours before the experiment, and 200 mg / kg of 2% alloxone solution prepared by mixing fresh in each tank except the normal tank intraperitoneally. After 48 hours, fasting blood glucose levels of animals fasted for 12 hours were measured, and 40 rats with diabetes exceeding 16.67 mmol / L were divided into 4 groups of 10 rats. Ten normal rats did not receive alloxone. Normal and model tanks were administered with an equivalent amount of physiological saline to the abdominal cavity, and drug tanks were administered 5 mg / kg to the rat abdominal cavity, and to the composition administration tank of the present invention, 2 g / kg and 1 g / kg of the composition of the present invention. Were administered to the rat abdominal cavity, respectively. All were administered for 15 days. Before administration and 15 days after administration, approximately 0.05 ml of blood was collected from the rat tail and the fasting blood glucose level was measured using a US JD2DGA7CC microglucometer. The measured results are shown in Table 2.

Effect of the Composition of the Present Invention on Blood Glucose Levels in Alloxone-administered Diabetic Rats (× ± SD) Group stars Number of animals (n) Preparation amount (g / kg) Blood glucose level (mmol / L) Before dosing 15 days after dosing Normal tank (physiological saline) 10 - 8.26 ± 1.42 8.20 ± 1.38 Model tank (physiological saline) 10 - 24.36 ± 4.82 28.40 ± 5.43 Drug group (glybenclamide) 10 0.005 25.04 ± 4.94 12.06 ± 3.68 *** (57.5) Composition dosing tank of the present invention 10 2 24.85 ± 4.86 14.12 ± 3.84 *** (50.3) 10 One 24.62 ± 4.88 16.34 ± 4.25 *** (42.5)

※ mmol / L → mg / dl: × 17.90

※ Comparison with model: *** P <0.001

From the results described in Table 2, it can be seen that the composition of the present invention significantly lowers blood sugar levels in alloxone-administered diabetic rats like glybenclamide, which has already been proven to be effective as an antidiabetic agent.

When aloxone produces free radical OH, the gallbladder is excessively oxidized, causing insulin beta cells to be damaged, leading to diabetes. The composition of the present invention reduces the action of damaging such beta cells to restore insulin to normal.

Experimental Example 3

<Glucose lowering effect of the composition of the present invention on rats receiving adrenaline>

Fifty male Wister male rats weighing 180 ± 20 g were divided into 5 groups of 10 animals per group. Fast 24 hours before the experiment, inject 0.2 ml / kg of 0.1% adrenaline into the subcutaneous rats except normal rats, inject the same amount of saline into the subcutaneous rats, and the same amount of saline into the subcutaneous rats. Immediately after injection, another drug was administered intraperitoneally. After 90 minutes and 130 minutes, about 0.05ml of blood was collected from the tails of large mice, and blood glucose levels were measured using a US-based JD2DGA7CC microglucometer. The measured results are shown in Table 3.

Effect of the Composition of the Invention on Blood Glucose in Adrenergic Diabetic Rats (× ± SD) Group stars Number of animals (n) Preparation amount (g / kg) Blood glucose level (mmol / L) 90 minutes 130 minutes Normal tank (physiological saline) 10 - 6.24 ± 1.40 6.26 ± 1.44 Model tank (physiological saline) 10 - 18.80 ± 3.64 *** 16.5 ± 3.12 ** Drug group (glybenclamide) 10 0.005 10.20 ± 2.68 *** (45.7) 8.24 ± 2.04 *** (50.1) Composition dosing tank of the present invention 10 2 12.34 ± 3.01 *** (34.4) 11.04 ± 2.42 *** (30.9) 10 One 13.65 ± 3.34 *** (27.4) 12.80 ± 3.05 * (22.4)

※ mmol / L → mg / dl: × 17.90

※ Comparison with model: * P <0.05, ** P <0.01, *** P <0.001

From the results shown in Table 3, it can be seen that the composition of the present invention lowers the blood sugar of the adrenaline diabetic rats while almost reducing the blood sugar of the normal pups.

Experimental Example 4

Acute Toxicity Test

Thirty white mice weighing 20 ± 2 g were selected, and 5 g / ml (maximum concentration) of the composition of the present invention were administered three times for 24 hours in each of the abdominal cavity of the male and female without discrimination. , And all of them survived for 10 days, and there was no adverse reaction. The maximum endurance multiples of white pups are calculated as follows.

According to the above experimental results, the composition of the present invention is injected once into the abdominal cavity of a white mouse, the maximum endurance is 250g / ㎏ (5g / 20g), the maximum endurance amount reaches 347.2 times. In addition, the maximum endurance injected per day is 750g / kg (15g / 20g), the maximum endurance multiple is 1041.7 times. Administering 750g / kg / day shows the effect of administering more than 3.75kg of the composition of the present invention in terms of 50kg body weight per day it can be seen that the composition of the present invention is substantially non-toxic.

As described above, the composition of the present invention includes various herbal ingredients in the oxaloacetic acid component of the stomach to prevent side effects due to the use of the stomach alone as well as to properly treat all the various symptoms that may be caused by diabetes. There is an excellent therapeutic effect on ischemic diabetes, namely type 2 diabetes.

In addition, the composition of the present invention is almost non-toxic and can be applied to a blood sugar-lowering health food.

Claims (4)

Composition for the treatment of diabetes comprising stomach, fruit, phalanx, corn salt, dansam, baekchul, turmeric, fueryeong, taeksa, earth and sand, and short skin The composition for treating diabetes of claim 1, wherein the composition for treating diabetes is blended in a weight ratio of 30: 10: 10: 10: 5: 5: 5: 7: 5: 5: 3. According to claim 1, wherein the composition for the treatment of diabetes consisting of any one of capsules, suspensions, pills, tablets, liquid formulations Hypoglycemic health supplements, including stomach, fruit, phalanges, corn salt, salvia, white currant, turmeric, fueryeong, taeksa, earth and sand, and skin