KR100315898B1 - 아데노신a1수용체길항제로서의크산틴유도체 - Google Patents

아데노신a1수용체길항제로서의크산틴유도체 Download PDF

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Publication number
KR100315898B1
KR100315898B1 KR1019950703577A KR19950703577A KR100315898B1 KR 100315898 B1 KR100315898 B1 KR 100315898B1 KR 1019950703577 A KR1019950703577 A KR 1019950703577A KR 19950703577 A KR19950703577 A KR 19950703577A KR 100315898 B1 KR100315898 B1 KR 100315898B1
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KR
South Korea
Prior art keywords
dipropyl
dihydro
dione
purin
acid
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1019950703577A
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English (en)
Korean (ko)
Inventor
재니스 엠. 히치콕
스티븐 엠. 소렌슨
마르크 더블유. 두들리
노튼 피. 피이트
Original Assignee
슈테펜엘.네스비트
메렐 파마슈티칼스 인크.
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Publication of KR100315898B1 publication Critical patent/KR100315898B1/ko
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1019950703577A 1993-02-26 1994-01-27 아데노신a1수용체길항제로서의크산틴유도체 Expired - Fee Related KR100315898B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2350193A 1993-02-26 1993-02-26
US08/023501 1993-02-26
PCT/US1994/001009 WO1994019349A1 (en) 1993-02-26 1994-01-27 Xanthine derivatives as adenosine a1 receptor antagonists

Publications (1)

Publication Number Publication Date
KR100315898B1 true KR100315898B1 (ko) 2002-02-28

Family

ID=21815459

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950703577A Expired - Fee Related KR100315898B1 (ko) 1993-02-26 1994-01-27 아데노신a1수용체길항제로서의크산틴유도체

Country Status (19)

Country Link
US (1) US5840729A (cg-RX-API-DMAC10.html)
EP (1) EP0686155B1 (cg-RX-API-DMAC10.html)
JP (1) JPH08512281A (cg-RX-API-DMAC10.html)
KR (1) KR100315898B1 (cg-RX-API-DMAC10.html)
CN (1) CN1041418C (cg-RX-API-DMAC10.html)
AT (1) ATE169019T1 (cg-RX-API-DMAC10.html)
AU (1) AU680241B2 (cg-RX-API-DMAC10.html)
CA (1) CA2155130C (cg-RX-API-DMAC10.html)
DE (1) DE69412073T2 (cg-RX-API-DMAC10.html)
DK (1) DK0686155T3 (cg-RX-API-DMAC10.html)
ES (1) ES2120025T3 (cg-RX-API-DMAC10.html)
HU (1) HUT72677A (cg-RX-API-DMAC10.html)
IL (1) IL108750A (cg-RX-API-DMAC10.html)
MX (1) MX9401406A (cg-RX-API-DMAC10.html)
NO (1) NO311920B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ262984A (cg-RX-API-DMAC10.html)
TW (1) TW261532B (cg-RX-API-DMAC10.html)
WO (1) WO1994019349A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA941176B (cg-RX-API-DMAC10.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0972525A4 (en) * 1997-03-18 2000-11-29 Fujisawa Pharmaceutical Co PREVENTIVE AND HEALING AGENTS AGAINST HYPERPHOSPHATEMIA
HUP0103836A3 (en) 1998-06-02 2003-05-28 Osi Pharmaceuticals Inc Uniond Pyrrolo[2,3d]pyrimidine compositions and their use
US6680322B2 (en) 1999-12-02 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US6680324B2 (en) 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US20020115635A1 (en) * 2001-02-21 2002-08-22 Pnina Fishman Modulation of GSK-3beta activity and its different uses
JP2005529062A (ja) 2001-11-30 2005-09-29 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド アデノシンａ１及びａ３受容体に特異的な化合物とその使用
KR20040068317A (ko) 2001-12-20 2004-07-30 오에스아이 파마슈티컬스, 인코포레이티드 피리미딘 ａ₂ｂ 선택성 길항 화합물, 그의 합성 방법 및용도
US6903220B2 (en) * 2002-05-15 2005-06-07 Genzyme Corporation Synthesis of chiral 2-alkyl amino acids
WO2004086047A2 (en) * 2003-03-28 2004-10-07 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g-protein-coupled receptor adenosine a1 (adora1)
KR20060124615A (ko) * 2003-12-09 2006-12-05 교와 핫꼬 고교 가부시끼가이샤 고차 뇌기능 장애의 예방 및/또는 치료제
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7795427B2 (en) * 2006-02-14 2010-09-14 New York University Methods for inhibiting osteoclast differentiation, formation, or function and for increasing bone mass

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0449175A2 (en) * 1990-03-26 1991-10-02 Merrell Pharmaceuticals Inc. Selective adenosine receptor agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3843117A1 (de) * 1988-12-22 1990-06-28 Boehringer Ingelheim Kg Neue xanthinderivate mit adenosin-antagonistischer wirkung
DE4019892A1 (de) * 1990-06-22 1992-01-02 Boehringer Ingelheim Kg Neue xanthinderivate
JPH0455150A (ja) * 1990-06-22 1992-02-21 Takata Kk 助手席用エアバッグ装置
US5087827A (en) * 1991-02-11 1992-02-11 Tektronix, Inc. Variable voltage transition circuit
US5208240A (en) * 1991-03-12 1993-05-04 Merrell Dow Pharmaceuticals Inc. 8-substituted purines as selective adenosine receptor agents
US5281607B1 (en) * 1992-10-08 1998-05-19 Univ New York Method of using alpha 2-antagonists for the treatment of neurodegenerative diseases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0449175A2 (en) * 1990-03-26 1991-10-02 Merrell Pharmaceuticals Inc. Selective adenosine receptor agents

Also Published As

Publication number Publication date
DE69412073D1 (de) 1998-09-03
JPH08512281A (ja) 1996-12-24
AU680241B2 (en) 1997-07-24
DK0686155T3 (da) 1999-02-01
IL108750A (en) 2000-09-28
CN1118599A (zh) 1996-03-13
IL108750A0 (en) 1994-05-30
DE69412073T2 (de) 1999-02-18
CA2155130C (en) 1994-09-01
EP0686155A1 (en) 1995-12-13
ES2120025T3 (es) 1998-10-16
ATE169019T1 (de) 1998-08-15
NO953353D0 (no) 1995-08-25
MX9401406A (es) 1994-08-31
NO953353L (no) 1995-08-25
EP0686155B1 (en) 1998-07-29
TW261532B (cg-RX-API-DMAC10.html) 1995-11-01
CA2155130A1 (en) 1994-09-01
NO311920B1 (no) 2002-02-18
NZ262984A (en) 1997-05-26
WO1994019349A1 (en) 1994-09-01
AU6296894A (en) 1994-09-14
ZA941176B (en) 1994-09-20
HUT72677A (en) 1996-05-28
HU9502495D0 (en) 1995-10-30
US5840729A (en) 1998-11-24
CN1041418C (zh) 1998-12-30

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