KR100234445B1 - (((아릴알킬피페리딘-4-일)메틸)-2a,3,4,5-테트라하이드로-1(2h)-아세나프틸렌-1-온 및 관련 화합물,이의 제조방법 및 이를 포함하는 약제학적 조성물 - Google Patents

(((아릴알킬피페리딘-4-일)메틸)-2a,3,4,5-테트라하이드로-1(2h)-아세나프틸렌-1-온 및 관련 화합물,이의 제조방법 및 이를 포함하는 약제학적 조성물 Download PDF

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Publication number
KR100234445B1
KR100234445B1 KR1019920009765A KR920009765A KR100234445B1 KR 100234445 B1 KR100234445 B1 KR 100234445B1 KR 1019920009765 A KR1019920009765 A KR 1019920009765A KR 920009765 A KR920009765 A KR 920009765A KR 100234445 B1 KR100234445 B1 KR 100234445B1
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KR
South Korea
Prior art keywords
compound
hydrogen
methyl
acenaphthylene
tetrahydro
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Expired - Fee Related
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KR1019920009765A
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English (en)
Korean (ko)
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KR930000483A (ko
Inventor
2세 레이몬드더블유.코슬리
베티나스팔
Original Assignee
제롬 로젠스톡
훽스트-러셀 파마슈티칼즈 인코포레이티드
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Publication of KR930000483A publication Critical patent/KR930000483A/ko
Application granted granted Critical
Publication of KR100234445B1 publication Critical patent/KR100234445B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Lubricants (AREA)
KR1019920009765A 1991-06-07 1992-06-05 (((아릴알킬피페리딘-4-일)메틸)-2a,3,4,5-테트라하이드로-1(2h)-아세나프틸렌-1-온 및 관련 화합물,이의 제조방법 및 이를 포함하는 약제학적 조성물 Expired - Fee Related KR100234445B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/713,249 US5106856A (en) 1991-06-07 1991-06-07 [(Arylalkylpiperidin-4-yl)methyl]-2a,3,4,5-tetrahydro-1(2H)-acenaphthylen-1-ones and related compounds
US7/713,249 1991-06-07
US07/713,249 1991-06-07

Publications (2)

Publication Number Publication Date
KR930000483A KR930000483A (ko) 1993-01-15
KR100234445B1 true KR100234445B1 (ko) 1999-12-15

Family

ID=24865395

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920009765A Expired - Fee Related KR100234445B1 (ko) 1991-06-07 1992-06-05 (((아릴알킬피페리딘-4-일)메틸)-2a,3,4,5-테트라하이드로-1(2h)-아세나프틸렌-1-온 및 관련 화합물,이의 제조방법 및 이를 포함하는 약제학적 조성물

Country Status (23)

Country Link
US (1) US5106856A (enExample)
EP (1) EP0517221B1 (enExample)
JP (1) JP2961013B2 (enExample)
KR (1) KR100234445B1 (enExample)
AT (1) ATE131814T1 (enExample)
AU (1) AU646784B2 (enExample)
CA (1) CA2070714A1 (enExample)
CZ (1) CZ284591B6 (enExample)
DE (1) DE69206889T2 (enExample)
DK (1) DK0517221T3 (enExample)
ES (1) ES2081517T3 (enExample)
FI (1) FI101297B (enExample)
GR (1) GR3018558T3 (enExample)
HU (1) HU217967B (enExample)
IE (1) IE72199B1 (enExample)
IL (1) IL102118A (enExample)
MX (1) MX9202736A (enExample)
NO (1) NO178889C (enExample)
NZ (1) NZ243013A (enExample)
PL (1) PL169423B1 (enExample)
RU (1) RU2043989C1 (enExample)
TW (1) TW206214B (enExample)
ZA (1) ZA924109B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW248556B (enExample) * 1993-01-18 1995-06-01 Takeda Pharm Industry Co
US6939879B2 (en) * 1998-08-28 2005-09-06 Aventis Pharmaceuticals Inc. Use of R (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol for the treatment of substance induced insomnia
NZ510685A (en) 1998-09-30 2003-10-31 Takeda Chemical Industries Ltd Drugs for improving vesical excretory strength
EA037187B1 (ru) * 2010-02-09 2021-02-17 Дзе Джонс Хопкинс Юниверсити Способ и композиция для лечения когнитивного расстройства
BR112013012062B1 (pt) 2010-11-15 2020-06-02 Agenebio, Inc Composto derivado da piridazina ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica e uso do composto
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
US10806717B2 (en) 2013-03-15 2020-10-20 The Johns Hopkins University Methods and compositions for improving cognitive function
JP6433482B2 (ja) 2013-03-15 2018-12-05 エージンバイオ， インコーポレイテッド 認知機能を改善するための方法および組成物
NZ722077A (en) 2013-12-20 2021-12-24 Agenebio Inc Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
AU2016268096B2 (en) 2015-05-22 2021-04-01 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam
CN108026107B (zh) 2015-06-19 2021-07-30 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物、组合物和方法
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
IL279530B1 (en) 2018-06-19 2025-09-01 Agenebio Inc Benzodiazepine history, preparations, and methods for treating cognitive disorder
AU2023324882A1 (en) 2022-08-19 2025-03-20 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2589934A (en) * 1950-08-24 1952-03-18 Abbott Lab 2-aminomethyl-tetrahydroacenapthones-1 and their preparation
US3391178A (en) * 1964-12-30 1968-07-02 Ernest E. Campaigne Dialkylaminoalkyl 1-oxo-2alpha, 3, 4, 5-tetrahydroacenaphthen-2alpha-carboxylates
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
JP2969359B2 (ja) * 1989-01-13 1999-11-02 武田薬品工業株式会社 環状アミン化合物

Also Published As

Publication number Publication date
FI922592L (fi) 1992-12-08
FI101297B1 (fi) 1998-05-29
DE69206889T2 (de) 1996-05-30
KR930000483A (ko) 1993-01-15
PL169423B1 (pl) 1996-07-31
EP0517221A1 (en) 1992-12-09
IL102118A (en) 1996-05-14
NO178889C (no) 1996-06-26
EP0517221B1 (en) 1995-12-20
NO178889B (no) 1996-03-18
ATE131814T1 (de) 1996-01-15
DE69206889D1 (de) 1996-02-01
FI101297B (fi) 1998-05-29
DK0517221T3 (da) 1996-04-22
ZA924109B (en) 1993-02-24
PL294803A1 (en) 1993-07-26
RU2043989C1 (ru) 1995-09-20
CS171392A3 (en) 1992-12-16
IL102118A0 (en) 1993-01-14
HU217967B (hu) 2000-05-28
NO922223L (no) 1992-12-08
CZ284591B6 (cs) 1999-01-13
CA2070714A1 (en) 1992-12-08
MX9202736A (es) 1993-01-01
HU9201887D0 (en) 1992-08-28
JPH06116237A (ja) 1994-04-26
JP2961013B2 (ja) 1999-10-12
AU1801592A (en) 1992-12-10
HUT65605A (en) 1994-07-28
US5106856A (en) 1992-04-21
AU646784B2 (en) 1994-03-03
IE921840A1 (en) 1992-12-16
FI922592A0 (fi) 1992-06-04
NO922223D0 (no) 1992-06-05
ES2081517T3 (es) 1996-03-16
IE72199B1 (en) 1997-04-09
NZ243013A (en) 1995-04-27
GR3018558T3 (en) 1996-03-31
TW206214B (enExample) 1993-05-21

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