KR100217807B1 - 9-푸리닐 포스폰산 유도체 - Google Patents

9-푸리닐 포스폰산 유도체 Download PDF

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Publication number
KR100217807B1
KR100217807B1 KR1019910011290A KR910011290A KR100217807B1 KR 100217807 B1 KR100217807 B1 KR 100217807B1 KR 1019910011290 A KR1019910011290 A KR 1019910011290A KR 910011290 A KR910011290 A KR 910011290A KR 100217807 B1 KR100217807 B1 KR 100217807B1
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KR
South Korea
Prior art keywords
compound
mmol
formula
phenyl
thiophene
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1019910011290A
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English (en)
Korean (ko)
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KR920002622A (ko
Inventor
알라지 세르쥬
당쟁 샤를르
Original Assignee
슈테펜엘.네스비트
메렐 다우 파마슈티칼스 인크.
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Publication of KR920002622A publication Critical patent/KR920002622A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1019910011290A 1990-07-04 1991-07-04 9-푸리닐 포스폰산 유도체 Expired - Fee Related KR100217807B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP90401940 1990-07-04
EP90401940.3 1990-07-04

Publications (2)

Publication Number Publication Date
KR920002622A KR920002622A (ko) 1992-02-28
KR100217807B1 true KR100217807B1 (ko) 1999-10-01

Family

ID=8205733

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910011290A Expired - Fee Related KR100217807B1 (ko) 1990-07-04 1991-07-04 9-푸리닐 포스폰산 유도체

Country Status (22)

Country Link
US (2) US5538978A (cg-RX-API-DMAC10.html)
EP (1) EP0465297B1 (cg-RX-API-DMAC10.html)
JP (1) JP3006919B2 (cg-RX-API-DMAC10.html)
KR (1) KR100217807B1 (cg-RX-API-DMAC10.html)
CN (1) CN1031713C (cg-RX-API-DMAC10.html)
AT (1) ATE133678T1 (cg-RX-API-DMAC10.html)
AU (1) AU643533B2 (cg-RX-API-DMAC10.html)
CA (1) CA2045783C (cg-RX-API-DMAC10.html)
DE (1) DE69116750T2 (cg-RX-API-DMAC10.html)
DK (1) DK0465297T3 (cg-RX-API-DMAC10.html)
ES (1) ES2085446T3 (cg-RX-API-DMAC10.html)
FI (1) FI101793B1 (cg-RX-API-DMAC10.html)
GR (1) GR3019793T3 (cg-RX-API-DMAC10.html)
HU (1) HU208832B (cg-RX-API-DMAC10.html)
IE (1) IE72096B1 (cg-RX-API-DMAC10.html)
IL (1) IL98702A (cg-RX-API-DMAC10.html)
MX (1) MX9203682A (cg-RX-API-DMAC10.html)
NO (1) NO180541C (cg-RX-API-DMAC10.html)
NZ (1) NZ238774A (cg-RX-API-DMAC10.html)
PT (1) PT98198B (cg-RX-API-DMAC10.html)
TW (1) TW199896B (cg-RX-API-DMAC10.html)
ZA (1) ZA914978B (cg-RX-API-DMAC10.html)

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DK0465297T3 (da) * 1990-07-04 1996-02-19 Merrell Pharma Inc 9-Purinylphosphonsyre-derivater
EP0531597A1 (en) * 1991-09-12 1993-03-17 Merrell Dow Pharmaceuticals Inc. Novel unsaturated acyclic phosphonate derivatives of purine and pyrimidine
CA2084222C (en) * 1991-12-06 2004-04-06 David R. Borcherding Novel trans cyclopentanyl purine analogs useful as immunosuppressants
US5723466A (en) * 1991-12-06 1998-03-03 Hoechst Marion Roussel, Inc. Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817672A (en) * 1991-12-06 1998-10-06 Hoechst Marion Roussel, Inc. Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817660A (en) * 1991-12-06 1998-10-06 Hoechst Marion Roussel, Inc. Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817661A (en) * 1991-12-06 1998-10-06 Hoechst Marion Roussel, Inc. Trans cyclopentanyl purine analogs useful as immunosuppressants
CA2171868A1 (en) * 1993-09-17 1995-03-23 Petr Alexander Method for dosing therapeutic compounds
US5798340A (en) * 1993-09-17 1998-08-25 Gilead Sciences, Inc. Nucleotide analogs
US5656745A (en) * 1993-09-17 1997-08-12 Gilead Sciences, Inc. Nucleotide analogs
US5703058A (en) * 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
MY141789A (en) * 2001-01-19 2010-06-30 Lg Chem Investment Ltd Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same.
EP1440072A4 (en) 2001-10-30 2005-02-02 Conforma Therapeutic Corp PURINE ANALOGS HAVING HSP90 INHIBITORY ACTIVITY
TW200408645A (en) 2002-04-26 2004-06-01 Gilead Sciences Inc Non nucleoside reverse transcriptase inhibitors
US7470724B2 (en) 2003-04-25 2008-12-30 Gilead Sciences, Inc. Phosphonate compounds having immuno-modulatory activity
US7452901B2 (en) 2003-04-25 2008-11-18 Gilead Sciences, Inc. Anti-cancer phosphonate analogs
WO2005002626A2 (en) 2003-04-25 2005-01-13 Gilead Sciences, Inc. Therapeutic phosphonate compounds
SG182849A1 (en) 2003-04-25 2012-08-30 Gilead Sciences Inc Antiviral phosphonate analogs
WO2004096285A2 (en) 2003-04-25 2004-11-11 Gilead Sciences, Inc. Anti-infective phosphonate conjugates
EP1620109A2 (en) 2003-04-25 2006-02-01 Gilead Sciences, Inc. Kinase inhibitor phosphonate conjugates
US7432261B2 (en) 2003-04-25 2008-10-07 Gilead Sciences, Inc. Anti-inflammatory phosphonate compounds
US7407965B2 (en) 2003-04-25 2008-08-05 Gilead Sciences, Inc. Phosphonate analogs for treating metabolic diseases
US7427636B2 (en) 2003-04-25 2008-09-23 Gilead Sciences, Inc. Inosine monophosphate dehydrogenase inhibitory phosphonate compounds
NZ546611A (en) 2003-09-18 2010-02-26 Conforma Therapeutics Corp Novel heterocyclic compounds as HSP90-inhibitors
US7432273B2 (en) 2003-10-24 2008-10-07 Gilead Sciences, Inc. Phosphonate analogs of antimetabolites
WO2005042773A1 (en) 2003-10-24 2005-05-12 Gilead Sciences, Inc. Methods and compositions for identifying therapeutic compounds
WO2005044279A1 (en) * 2003-10-24 2005-05-19 Gilead Sciences, Inc. Purine nucleoside phosphonate conjugates
BRPI0417988A (pt) 2003-12-22 2007-04-27 Gilead Sciences Inc análogos de fosfonato antivirais
PT2258376T (pt) 2004-07-27 2019-05-31 Gilead Sciences Inc Análogos fosfonatados de compostos inibidores do vih
BRPI0609509A2 (pt) 2005-03-30 2010-04-13 Conforma Therapeutics Corp composto ou um polimorfo, solvato, tautÈmero, enanciÈmero, pró-droga ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso do composto, polimorfo, solvato, tautÈmero, enanciÈmero, pró-droga ou sal farmaceuticamente aceitável
US8158108B2 (en) * 2006-06-28 2012-04-17 S.C. Johnson & Son, Inc. VOC-free compressed gas aerosol compositions
US8178078B2 (en) * 2008-06-13 2012-05-15 S.C. Johnson & Son, Inc. Compositions containing a solvated active agent suitable for dispensing as a compressed gas aerosol
BRPI0915878A2 (pt) 2008-07-08 2015-11-03 Gilead Sciences Inc sais ou hidratos de compostos inibidores de hiv, seu uso e composição farmacêutica que os compreende
KR101692133B1 (ko) 2015-01-13 2017-01-02 연세대학교 원주산학협력단 폴리이미드 수용액을 이용한 폴리이미드 성형방법
CN105061504A (zh) * 2015-09-16 2015-11-18 湖南大学 P-炔基磷酸酯类化合物的制备方法
PT3661937T (pt) 2017-08-01 2021-09-24 Gilead Sciences Inc Formas cristalinas de ((s)-((((2r,5r)-5-(6-amino-9h-purin-9-il)-4-fluoro-2,5-dihidrofurano-2-il)oxi)metil)(fenoxi)fosforil)-l-alaninato de etil (gs-9131) para tratamento de infeções virais

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1288098C (en) * 1984-08-24 1991-08-27 Richard L. Tolman 4-(guanin-9-yl)butanals and their 3-oxa, 3-thia and 2-ene derivatives having antiviral and antitumor activity
US4988702A (en) * 1986-08-26 1991-01-29 Warner-Lambert Company Novel 9-deazaguanines
EP0328834A1 (en) * 1988-02-16 1989-08-23 Merrell Dow Pharmaceuticals Inc. Novel aspartate transcarbamylase inhibitors
EP0335770B1 (en) * 1988-04-01 1997-01-15 Merrell Pharmaceuticals Inc. Novel fluorophosphonate nucleotide derivatives
US4927830A (en) * 1988-04-08 1990-05-22 The Regents Of The University Of Michigan Acyclic pyrrolo[2,3-D]pyrimidine analogs as antiviral agents
EP0338168A1 (en) * 1988-04-19 1989-10-25 Merrell Dow Pharmaceuticals Inc. Phosphonoalkylpurine derivatives
ATE98249T1 (de) * 1988-04-19 1993-12-15 Merrell Dow Pharma Phosphonoalkylpurin-derivate.
JPH02124898A (ja) * 1988-04-28 1990-05-14 Nippon Kayaku Co Ltd プリン塩基を有する新規化合物、その用途及び中間体
JPH02124897A (ja) * 1988-07-28 1990-05-14 Nippon Kayaku Co Ltd エリスロフラノシルヌクレオシド誘導体の製造法及び新規誘導体
GB8827339D0 (en) * 1988-11-23 1988-12-29 Wellcome Found Antiviral compounds
EP0374096B1 (de) * 1988-12-14 1992-12-02 Ciba-Geigy Ag 2',3'-Dideoxypurinnucleosid/Purinnucleosid-Phosphorylase-Inhibitor Kombinationstherapie und Zusammensetzungen dafür
DK0465297T3 (da) * 1990-07-04 1996-02-19 Merrell Pharma Inc 9-Purinylphosphonsyre-derivater
EP0468119A1 (en) * 1990-07-24 1992-01-29 Merrell Dow Pharmaceuticals Inc. Novel carbocyclic analogs of certain nucleosides
EP0477454A1 (en) * 1990-09-28 1992-04-01 Merrell Dow Pharmaceuticals Inc. Novel phosphonate derivatives of certain nucleosides

Also Published As

Publication number Publication date
NO180541C (no) 1997-05-07
PT98198A (pt) 1992-04-30
JP3006919B2 (ja) 2000-02-07
JPH04253989A (ja) 1992-09-09
NZ238774A (en) 1993-08-26
DK0465297T3 (da) 1996-02-19
HU208832B (en) 1994-01-28
ZA914978B (en) 1992-04-29
FI101793B (fi) 1998-08-31
DE69116750D1 (de) 1996-03-14
ES2085446T3 (es) 1996-06-01
MX9203682A (es) 1992-08-01
CA2045783A1 (en) 1992-01-05
IL98702A0 (en) 1992-07-15
IL98702A (en) 1997-02-18
CA2045783C (en) 2001-09-18
ATE133678T1 (de) 1996-02-15
KR920002622A (ko) 1992-02-28
NO180541B (no) 1997-01-27
IE912329A1 (en) 1992-01-15
EP0465297A1 (en) 1992-01-08
PT98198B (pt) 1998-12-31
FI913236A0 (fi) 1991-07-03
EP0465297B1 (en) 1996-01-31
NO912606D0 (no) 1991-07-03
CN1031713C (zh) 1996-05-01
DE69116750T2 (de) 1996-11-14
CN1058021A (zh) 1992-01-22
FI101793B1 (fi) 1998-08-31
IE72096B1 (en) 1997-03-12
HUT59151A (en) 1992-04-28
HU912253D0 (en) 1991-12-30
GR3019793T3 (en) 1996-07-31
AU643533B2 (en) 1993-11-18
US5538978A (en) 1996-07-23
TW199896B (cg-RX-API-DMAC10.html) 1993-02-11
FI913236L (fi) 1992-01-05
US5527803A (en) 1996-06-18
AU7941491A (en) 1992-01-09
NO912606L (no) 1992-01-06

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