KR0156661B1 - Germanium compounds with improved cosmetic effect - Google Patents

Abstract

The present invention provides a human cleanser composition containing organo germanium in which skin cosmetic effects are enhanced by skin adsorption accelerators such as fatty acids, urea and azone. The human body cleaner composition of the present invention is characterized by containing 0.001-10% by weight of organic germanium and 0.1-15% by weight of a skin adsorption accelerator based on the total weight of the composition.

Description

Human cleanser composition containing organic germanium with enhanced skin beauty effect by skin adsorption accelerator such as fatty acid, urea and azone

The present invention relates to a human cleanser composition containing an organic germanium whose skin cosmetic effect is enhanced by a skin adsorption accelerator such as fatty acids, urea and azone, and more particularly, an organic germanium having an excellent effect on skin beauty. The present invention relates to a human cleanser, ie, a solid soap and a liquid human cleanser composition, which contains a skin adsorption accelerator such as fatty acid, urea, and azone, and exhibits excellent skin cosmetic effects by enhancing the skin permeability of organic germanium.

Many women who want healthy skin suffer from skin problems such as acne, blotch, freckles and blemishes. Acne is caused by a number of factors, including stimulating food intake, hormonal imbalances, and genetic congenitals. Spots, freckles, and black mushrooms are very difficult to get rid of once due to pigmentation. These skin problems occur when the skin is naturally less resistant to external irritation. There has been an ongoing effort to treat skin problems. However, no clear achievements have been made so far, because the existing methods only stay in phenomenal treatment and lack a fundamental approach.

In other words, conventional short-term healing agents such as hydrogen peroxide, zinc oxide, aloe, tocopherol, citric acid and the like have been generally used. However, their efficacy and effect is insufficient, so long-term use is inevitable, causing inconvenience in life, and for some drugs, side effects are expected.

The inventions of Japanese Patents JP62-111908 have attempted a fundamental treatment of skin problems using plant extracts containing germanium. When the plant extract ingredient containing the natural germanium compound obtained from the plant is used in liquid or cream state, it provides sufficient oxygen to the epidermis, dermis and subcutaneous tissue to improve the nutrition of the epidermis, dermis and subcutaneous tissue and enhance the cosmetic effect. It is confirmed that it exerted. However, the exact chemical structure of the germanium compounds extracted from plants is not known and it is only assumed that they form complexes with sugars. In addition, the concentration of germanium compounds in plants is difficult to exceed the maximum 4000PPM, but the amount passing through the epidermis is very small, within 1%.

There are many ways to pass the skin through the external sample. First of all, there are methods through skin appendages such as sweat glands and hair pockets. Since the skin appendages occupy only 0.1% of the entire skin surface, it cannot be a main route of skin penetration. Most of the outermost part of the skin consists of cells without nuclei flattened into the stratum corneum with phospholipids in between. Skin permeation through the phospholipid layer between these stratum corneum cells or direct permeation of the cells is the main route of skin permeation, but since the stratum corneum acts as a barrier to permeation of external substances, only a small portion of the sample applied during permeation of external substances It can pass through the skin. Various efforts have been made to promote the absorption of drugs into the skin.

Until now, methods such as lontophoresis, occlusion, vesicle, and phonophoresis have been proposed and used clinically. However, the above methods are limited in consideration of convenience and have limitations to generalization.

Thus, the present inventors increase the concentration of the germanium compound by combining synthetic organic germanium of 99% or more hydrogen in the human cleanser and increase the skin permeability secured convenience and compatibility by skin adsorption accelerators such as fatty acids, urea, azone, etc. It was conceived that the composition could be provided.

Accordingly, it is an object of the present invention to provide a human detergent composition containing organo germanium in which skin cosmetic effects are enhanced by skin adsorption accelerators such as fatty acids, urea and azone.

In order to achieve the above object, the human cleanser composition according to the present invention is to increase the concentration of the germanium compound by combining synthetic organic germanium with a purity of 99% or more in the human cleanser and convenient and commercially available by the skin adsorption accelerator such as fatty acids, urea, azone It is characterized by increasing the skin transmittance secured sex.

Organic germanium is bis-Carboethoxy Germanium Sesquioxide, which has the following chemical structure: Germanium combines with oxygen to form a hexagonal planar structure of 12 elements, each hexagonal The planar structure of is a compound bonded by hydrogen bonding.

Organo germanium was first synthesized by Asai's team in Japan in 1967 and then synthesized by various manufacturing methods in each country (USP No.3.793 ~ 455, 1974 J.Am.Chem.Soc Vol.98, 8278 ~). 8289, 1976). Briefly looking at the synthesis method of the organic germanium, it is first obtained by reacting germanium or germanium dioxide with hydrogen chloride gas at high temperature to synthesize trichlorogermanium hydride and then react with acrylic acid and then hydrolyze. Moreover, it can also synthesize | combine using acrylonitrile, acrylamide, methylvinyl ketone, etc. instead of acrylic acid. On the other hand, since germanium dioxide, which is a starting material in the preparation of organic germanium, is highly toxic, high purity (more than 99%) is required for synthesis and purification of organic germanium.

Several useful biological properties of organogermanium have been found throughout animal and clinical studies, with interferon-inducing, immunomodulatory and anti-tumor effects of anti-cancer activity being particularly noteworthy (Microbiol. Immunol. 29 , 65-74, 1985 / J. Inferferon Res. 4,223, 1984 / Int. J. Immunother. 2,239-245, 1986). The fact that these bioregulatory and bioactive functions are expressed without any side effects or toxicity doubles the usefulness of organogermanium.

The mechanism of action of skin cosmetics by organo germanium has not yet been precisely determined, but it is generally accepted that it is due to oxygen supply to the skin and the role of scacenger on oxygen free radicals. It is a source.

Large amounts of waste generated by the metabolism of the human body are carbon dioxide and hydrogen ions, of which carbon dioxide is discharged out of the body through respiration and hydrogen ions are combined with oxygen and released in the form of water.

When organic germanium is introduced into the body, it induces the production of oxygen to help the hydrogen ions, which are waste products in the body, to be discharged in the form of water. Therefore, oxygen consumption in the body necessary for the release of hydrogen ions is suppressed, and oxygen can be supplied sufficiently to cells such as epidermis, dermis, and subcutaneous tissue, thereby improving the nutritional state of the skin.

Therefore, it is possible to prevent and treat skin problems such as acne, blemishes, and freckles, and has a great effect on skin beauty.

Oxygen free radicals are highly reactive substances that react randomly with most molecules and are the main cause of skin aging, which causes irregular bonds with tissues in the body, causing abnormalities in cellular tissues. Free radicals are caused by various sources such as living ultraviolet rays, electromagnetic waves, sunlight, and stress, so everyone is at risk. Organic germanium can, however, accept electrons from free radicals. In other words, germanium metal is a group of elements such as silicon and exhibits semiconducting properties. Therefore, germanium metal has a stronger affinity for electrons of oxygen free radicals than other atoms or molecules. It accepts electrons to protect the skin.

Various raw materials are used as skin adsorption accelerators such as sulfoxides, pyrrolidonenes, fatty acids, azone (1-dodecylazacycloheptan-2-one), urea, alcohols, and terpines. Effects such as Terpenes are known.

The inventors of the above-mentioned raw materials were mixed with each other in the preparation of the human detergent to determine the degree of improvement in efficacy and stability in the product, and found that the best in the solid soap and urea acid and urea in the liquid human detergent. This invention was completed.

Hereinafter, the present invention will be described in more detail.

The human cleanser composition of the present invention includes components in addition to the above-described characteristic components of a conventional soap or liquid human cleanser.

In preparing the soap of the present invention, the base was obtained by reacting caustic soda after appropriately mixing Uji, palm oil, coconut oil, and the like, and a whitening agent of titanium dioxide, a discoloration inhibitor, a pigment, a flavor, and the like were dry blended. After the addition of 0.001 ~ 10% by weight of organic germanium and 0.1 to 15% by weight of one of Oleic Acid, Urea, Azone and homogeneously mixed in a kneader (Kneader) was prepared by molding into a solid soap.

The body cleanser composition of the present invention is 5 to 20% by weight of anionic surfactants such as sodium lauryl ether sulfate (SLES), alpha olefin sulfonate (AOS), potassium laurate, fatty acid amide, coke amido propyl betaine, etc. 1 to 10% by weight of each of the thickener and aroma, discoloration inhibitors, pearling agents, pigments, preservatives and the like was uniformly mixed and then the pH was adjusted to 6-8. Then, the final product was obtained by uniformly mixing 0.001-10% by weight of organic germanium and 0.1-15% by weight of one of Oleic Acid, Urea, and Azone.

Hereinafter, the present invention will be described in more detail with reference to Examples, Comparative Examples, and Experimental Examples, but the present invention is not limited to these examples.

[Examples 1-3 and Comparative Example 1]

A solid soap was prepared using the ingredients shown in Table 1 below.

[Examples 4 to 6 and Comparative Example 2]

To prepare a liquid human cleanser using the ingredients shown in Table 2 below.

Experimental Example

Measurement experiment of skin beauty effect

The skin-cosmetic effect of the human cleanser containing organogerium was clinically measured.

[Experimental subject]

56 Korean women aged 28 to 32 who were interested in skin health were selected and the following experiment was conducted.

[Experimental method]

end. 56 women were randomly divided into eight groups of seven people, and each of the groups was used to use Examples 1 to 3, Comparative Example 1, and Examples 4 to 6 and Comparative Example 2.

I. The experiment lasted for 6 weeks, and a standard shower method was used to take a shower once a day to reduce the errors caused by the habits among the subjects.

All. After 6 weeks, skin health was checked by observing skin moisture level, skin elasticity, and skin surface condition using Direct Skin Analyzer.

[Experiment result]

end. Measurement of skin moisture content: Corneometer was used to measure changes in skin moisture content before and after using human cleanser.

I. Measurement of skin elasticity: Skin elasticity was measured before and after using a human cleanser using a cutometer.

All. Measurement of Skin Surface Condition: The skin surface was enlarged through a monitor using a Direct Skin Analyzer.

-A skin care professional compared the photos before and after 6 weeks of use of the human cleanser to determine the improvement of skin health according to the use of the human cleanser. At this time, the following results were obtained with the same tendency as the skin moisture content measurement and skin elasticity measurement results.

Comparative Example 1 Example 1 Example 2 3

Comparative Example 2 Example 4 Example 5 6

la. Discussion: As can be seen from the above experimental results, Examples 1 and 4 containing only organic germanium show excellent skin cosmetic effects compared to Comparative Examples 1 and 2, but the degree is not large. However, in Examples 2, 3, 5, and 6 in which a skin adsorption accelerator was added to an organic germanium-containing human cleanser, the skin cosmetic effect was greatly increased.

Claims (2)

In the human detergent composition containing organo germanium, organo germanium is contained in an amount of 0.001 to 10% by weight based on the total weight of the composition, oleic acid, lauric acid, linoleic acid, urea, Azone (Azone: 1-dodecylazacycloheptan- 2-one) human cleanser composition further comprises 0.1 to 15% by weight of the skin adsorption promoter selected from the group consisting of. According to claim 1, wherein the organic germanium is bis-carboethoxygermanium sesquioxide (Bis-Carboethoxygermanium Sesquioxide), the human cleanser composition, characterized in that.