JPWO2024089953A1 - - Google Patents
Info
- Publication number
- JPWO2024089953A1 JPWO2024089953A1 JP2024552830A JP2024552830A JPWO2024089953A1 JP WO2024089953 A1 JPWO2024089953 A1 JP WO2024089953A1 JP 2024552830 A JP2024552830 A JP 2024552830A JP 2024552830 A JP2024552830 A JP 2024552830A JP WO2024089953 A1 JPWO2024089953 A1 JP WO2024089953A1
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022172158 | 2022-10-27 | ||
| JP2022172158 | 2022-10-27 | ||
| PCT/JP2023/026108 WO2024089953A1 (ja) | 2022-10-27 | 2023-07-14 | オリゴヌクレオチドの製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2024089953A1 true JPWO2024089953A1 (https=) | 2024-05-02 |
| JPWO2024089953A5 JPWO2024089953A5 (https=) | 2025-01-08 |
| JP7825064B2 JP7825064B2 (ja) | 2026-03-05 |
Family
ID=90830457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024552830A Active JP7825064B2 (ja) | 2022-10-27 | 2023-07-14 | オリゴヌクレオチドの製造方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20250136632A1 (https=) |
| EP (1) | EP4477659A4 (https=) |
| JP (1) | JP7825064B2 (https=) |
| KR (1) | KR20250092173A (https=) |
| CN (1) | CN119948043A (https=) |
| WO (1) | WO2024089953A1 (https=) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005520547A (ja) * | 2002-03-21 | 2005-07-14 | アベシア・バイオテクノロジー・インコーポレーテッド | オリゴヌクレオチド及びその類似体のための精製方法 |
| US9481702B2 (en) * | 2011-08-25 | 2016-11-01 | Bonac Corporation | Glycoside compound, method for producing thioether, ether, method for producing ether, method for producing glycoside compound, method for producing nucleic acid |
| WO2019208571A1 (ja) * | 2018-04-24 | 2019-10-31 | 住友化学株式会社 | アミダイト化合物及び該化合物を用いたポリヌクレオチドの製造方法 |
| WO2022103842A1 (en) * | 2020-11-11 | 2022-05-19 | Biogen Ma Inc. | Oligonucleotides, reagents and preparation thereof |
| WO2022172994A1 (ja) * | 2021-02-12 | 2022-08-18 | 味の素株式会社 | オリゴヌクレオチドの製造方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5510476A (en) | 1994-07-07 | 1996-04-23 | Isis Pharmaceuticals, Inc. | Carbocation scavenging during oligonucleotide synthesis |
| US6077709A (en) | 1998-09-29 | 2000-06-20 | Isis Pharmaceuticals Inc. | Antisense modulation of Survivin expression |
| US6887990B1 (en) | 1999-02-05 | 2005-05-03 | Amersham Biosciences Corp | Method for deprotecting oligonucleotides |
| US6261840B1 (en) | 2000-01-18 | 2001-07-17 | Isis Pharmaceuticals, Inc. | Antisense modulation of PTP1B expression |
| AU2005275801B2 (en) | 2004-08-26 | 2012-05-10 | Nippon Shinyaku Co., Ltd. | Phosphoramidite compound and method for producing oligo-RNA |
| ES2526295T5 (es) | 2006-10-18 | 2021-05-04 | Ionis Pharmaceuticals Inc | Compuestos antisentido |
| EP2933333B1 (en) | 2010-07-08 | 2018-02-21 | Bonac Corporation | Single-strand nucleic acid molecule for controlling gene expression |
| DK2711370T3 (en) | 2011-05-17 | 2018-02-26 | Ajinomoto Kk | PROCEDURE FOR THE PREPARATION OF OLIGONUCLEOTIDES |
| AU2013266968B2 (en) | 2012-05-25 | 2017-06-29 | Emmanuelle CHARPENTIER | Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription |
| RU2736728C2 (ru) | 2014-10-17 | 2020-11-19 | Иллумина Кембридж Лимитед | Транспозиция с сохранением сцепления генов |
| CA2969619A1 (en) | 2014-12-03 | 2016-06-09 | Agilent Technologies, Inc. | Guide rna with chemical modifications |
| US10072261B1 (en) * | 2016-03-25 | 2018-09-11 | Agilent Technologies, Inc. | Double coupling method for oligonucleotide synthesis |
| US20210309690A1 (en) * | 2016-07-27 | 2021-10-07 | Roche Innovation Center Copenhagen A/S | Oligonucleotide synthesis |
| JPWO2018182008A1 (ja) | 2017-03-31 | 2020-02-06 | 株式会社ボナック | 遺伝子発現制御機能を有する環状型核酸分子 |
| BR112020005230A2 (pt) | 2017-09-19 | 2020-09-24 | Alnylam Pharmaceuticals, Inc. | composições e métodos para o tratamento da amiloidose mediada por transtiretina (ttr) |
| US20210188895A1 (en) | 2017-10-13 | 2021-06-24 | Bonac Corporation | Single-stranded nucleic acid molecule, and production method therefor |
| CN119143828A (zh) * | 2019-05-08 | 2024-12-17 | 渤健马萨诸塞州股份有限公司 | 寡核苷酸的汇聚液相合成 |
-
2023
- 2023-07-14 WO PCT/JP2023/026108 patent/WO2024089953A1/ja not_active Ceased
- 2023-07-14 EP EP23882170.6A patent/EP4477659A4/en active Pending
- 2023-07-14 US US18/858,394 patent/US20250136632A1/en active Pending
- 2023-07-14 KR KR1020257010625A patent/KR20250092173A/ko active Pending
- 2023-07-14 CN CN202380064746.6A patent/CN119948043A/zh active Pending
- 2023-07-14 JP JP2024552830A patent/JP7825064B2/ja active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005520547A (ja) * | 2002-03-21 | 2005-07-14 | アベシア・バイオテクノロジー・インコーポレーテッド | オリゴヌクレオチド及びその類似体のための精製方法 |
| US9481702B2 (en) * | 2011-08-25 | 2016-11-01 | Bonac Corporation | Glycoside compound, method for producing thioether, ether, method for producing ether, method for producing glycoside compound, method for producing nucleic acid |
| WO2019208571A1 (ja) * | 2018-04-24 | 2019-10-31 | 住友化学株式会社 | アミダイト化合物及び該化合物を用いたポリヌクレオチドの製造方法 |
| WO2022103842A1 (en) * | 2020-11-11 | 2022-05-19 | Biogen Ma Inc. | Oligonucleotides, reagents and preparation thereof |
| WO2022172994A1 (ja) * | 2021-02-12 | 2022-08-18 | 味の素株式会社 | オリゴヌクレオチドの製造方法 |
Non-Patent Citations (2)
| Title |
|---|
| ZAHAR, N. M. EL ET AL., BIOMEDICAL CHROMATOGRAPHY, vol. 32, no. 1, JPN6023037649, 2018, pages 4088, ISSN: 0005797604 * |
| 関口 光明 ほか, 医薬品医療機器レギュラトリーサイエンス, vol. 51(1), JPN6023037648, 2020, pages 11 - 21, ISSN: 0005797603 * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20250092173A (ko) | 2025-06-23 |
| JP7825064B2 (ja) | 2026-03-05 |
| EP4477659A4 (en) | 2025-07-30 |
| CN119948043A (zh) | 2025-05-06 |
| US20250136632A1 (en) | 2025-05-01 |
| EP4477659A1 (en) | 2024-12-18 |
| WO2024089953A1 (ja) | 2024-05-02 |
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