JP7825064B2 - オリゴヌクレオチドの製造方法 - Google Patents

オリゴヌクレオチドの製造方法

Info

Publication number
JP7825064B2
JP7825064B2 JP2024552830A JP2024552830A JP7825064B2 JP 7825064 B2 JP7825064 B2 JP 7825064B2 JP 2024552830 A JP2024552830 A JP 2024552830A JP 2024552830 A JP2024552830 A JP 2024552830A JP 7825064 B2 JP7825064 B2 JP 7825064B2
Authority
JP
Japan
Prior art keywords
group
oligonucleotide
formula
mer
represented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2024552830A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2024089953A5 (https=
JPWO2024089953A1 (https=
Inventor
雄樹 田中
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of JPWO2024089953A1 publication Critical patent/JPWO2024089953A1/ja
Publication of JPWO2024089953A5 publication Critical patent/JPWO2024089953A5/ja
Application granted granted Critical
Publication of JP7825064B2 publication Critical patent/JP7825064B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Saccharide Compounds (AREA)
JP2024552830A 2022-10-27 2023-07-14 オリゴヌクレオチドの製造方法 Active JP7825064B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022172158 2022-10-27
JP2022172158 2022-10-27
PCT/JP2023/026108 WO2024089953A1 (ja) 2022-10-27 2023-07-14 オリゴヌクレオチドの製造方法

Publications (3)

Publication Number Publication Date
JPWO2024089953A1 JPWO2024089953A1 (https=) 2024-05-02
JPWO2024089953A5 JPWO2024089953A5 (https=) 2025-01-08
JP7825064B2 true JP7825064B2 (ja) 2026-03-05

Family

ID=90830457

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024552830A Active JP7825064B2 (ja) 2022-10-27 2023-07-14 オリゴヌクレオチドの製造方法

Country Status (6)

Country Link
US (1) US20250136632A1 (https=)
EP (1) EP4477659A4 (https=)
JP (1) JP7825064B2 (https=)
KR (1) KR20250092173A (https=)
CN (1) CN119948043A (https=)
WO (1) WO2024089953A1 (https=)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005520547A (ja) 2002-03-21 2005-07-14 アベシア・バイオテクノロジー・インコーポレーテッド オリゴヌクレオチド及びその類似体のための精製方法
WO2019208571A1 (ja) 2018-04-24 2019-10-31 住友化学株式会社 アミダイト化合物及び該化合物を用いたポリヌクレオチドの製造方法
WO2022103842A1 (en) 2020-11-11 2022-05-19 Biogen Ma Inc. Oligonucleotides, reagents and preparation thereof
WO2022172994A1 (ja) 2021-02-12 2022-08-18 味の素株式会社 オリゴヌクレオチドの製造方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510476A (en) 1994-07-07 1996-04-23 Isis Pharmaceuticals, Inc. Carbocation scavenging during oligonucleotide synthesis
US6077709A (en) 1998-09-29 2000-06-20 Isis Pharmaceuticals Inc. Antisense modulation of Survivin expression
US6887990B1 (en) 1999-02-05 2005-05-03 Amersham Biosciences Corp Method for deprotecting oligonucleotides
US6261840B1 (en) 2000-01-18 2001-07-17 Isis Pharmaceuticals, Inc. Antisense modulation of PTP1B expression
AU2005275801B2 (en) 2004-08-26 2012-05-10 Nippon Shinyaku Co., Ltd. Phosphoramidite compound and method for producing oligo-RNA
ES2526295T5 (es) 2006-10-18 2021-05-04 Ionis Pharmaceuticals Inc Compuestos antisentido
EP2933333B1 (en) 2010-07-08 2018-02-21 Bonac Corporation Single-strand nucleic acid molecule for controlling gene expression
DK2711370T3 (en) 2011-05-17 2018-02-26 Ajinomoto Kk PROCEDURE FOR THE PREPARATION OF OLIGONUCLEOTIDES
MX370398B (es) * 2011-08-25 2019-12-11 Bonac Corp Compuesto de glicosido, metodo para producir tioeter, eter, metodo para producir eter, metodo para producir un compuesto de glicosido, metodo para producir acido nucleico.
AU2013266968B2 (en) 2012-05-25 2017-06-29 Emmanuelle CHARPENTIER Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
RU2736728C2 (ru) 2014-10-17 2020-11-19 Иллумина Кембридж Лимитед Транспозиция с сохранением сцепления генов
CA2969619A1 (en) 2014-12-03 2016-06-09 Agilent Technologies, Inc. Guide rna with chemical modifications
US10072261B1 (en) * 2016-03-25 2018-09-11 Agilent Technologies, Inc. Double coupling method for oligonucleotide synthesis
US20210309690A1 (en) * 2016-07-27 2021-10-07 Roche Innovation Center Copenhagen A/S Oligonucleotide synthesis
JPWO2018182008A1 (ja) 2017-03-31 2020-02-06 株式会社ボナック 遺伝子発現制御機能を有する環状型核酸分子
BR112020005230A2 (pt) 2017-09-19 2020-09-24 Alnylam Pharmaceuticals, Inc. composições e métodos para o tratamento da amiloidose mediada por transtiretina (ttr)
US20210188895A1 (en) 2017-10-13 2021-06-24 Bonac Corporation Single-stranded nucleic acid molecule, and production method therefor
CN119143828A (zh) * 2019-05-08 2024-12-17 渤健马萨诸塞州股份有限公司 寡核苷酸的汇聚液相合成

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005520547A (ja) 2002-03-21 2005-07-14 アベシア・バイオテクノロジー・インコーポレーテッド オリゴヌクレオチド及びその類似体のための精製方法
WO2019208571A1 (ja) 2018-04-24 2019-10-31 住友化学株式会社 アミダイト化合物及び該化合物を用いたポリヌクレオチドの製造方法
WO2022103842A1 (en) 2020-11-11 2022-05-19 Biogen Ma Inc. Oligonucleotides, reagents and preparation thereof
WO2022172994A1 (ja) 2021-02-12 2022-08-18 味の素株式会社 オリゴヌクレオチドの製造方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ZAHAR, N. M. EL et al.，Biomedical Chromatography，2018年，Vol. 32, No. 1，e4088，DOI: 10.1002/bmc.4088
関口 光明 ほか，医薬品医療機器レギュラトリーサイエンス，2020年，51(1)，Pages 11-21

Also Published As

Publication number Publication date
KR20250092173A (ko) 2025-06-23
JPWO2024089953A1 (https=) 2024-05-02
EP4477659A4 (en) 2025-07-30
CN119948043A (zh) 2025-05-06
US20250136632A1 (en) 2025-05-01
EP4477659A1 (en) 2024-12-18
WO2024089953A1 (ja) 2024-05-02

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